ALZA TTS RESEARCH PARTNERS LTD
SC 13D/A, 1998-08-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                       SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549
                           _________________________
                                  SCHEDULE 13D

                                 (RULE 13d-101)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO SCHEDULE 13d-1(A) AND
               AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(A)

                             (AMENDMENT NO. 1)/1/


                       ALZA TTS RESEARCH PARTNERS, LTD.
                 --------------------------------------------
                               (Name of Issuer)

                     Class A Limited Partnership Interests
             -----------------------------------------------------
                        (Title of Class of Securities)

                                Not Applicable
                       --------------------------------
                                 CUSIP Number
 

David R. Hoffmann               Peter D. Staple, Esq.     With a copy to:
President                       ALZA Corporation          Sarah A. O'Dowd, Esq.
ALZA Development Corporation    950 Page Mill Road        Heller Ehrman White 
950 Page Mill Road              P.O. Box 10950             & McAuliffe
P.O. Box 10950                  Palo Alto, CA 94303-0802  525 University Avenue
Palo Alto, CA 94303-0802        (650) 494-5000            Palo Alto, CA  94301 
(650) 494-5300                                            (650) 324-7000
   
________________________________________________________________________________
                      (Name, address and telephone number
                        of person authorized to receive
                          notices and communications)

                                August 14, 1998
                       ---------------------------------
                         (Date of Event which requires
                           filing of this statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-l(e), 13d-1(f) or 13d-1(g), check the following
box:                                                                 [_]

Note:  Schedules filed in paper format shall include a signed original and five
copies of this schedule, including all exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

                              (Page 1 of 5 Pages)

   /1/  The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

        The information required on the remainder of this cover page shall not
 be deemed to be "filed" for the purpose of Section 18 of the Securities
 Exchange Act of 1934 or otherwise subject to the liabilities of that section of
 the Act but shall be subject to all other provisions of the Act (however, see
 the Notes).
<PAGE>
 
                                                             PAGE 2 OF 5 PAGES

- ------------------------------------------------------------------------------
      Name of Reporting Persons and 
 1    S.S. or I.R.S. Identification No. 
      ALZA DEVELOPMENT CORPORATION
      I.R.S. Identification No.: 94-2853093

- ------------------------------------------------------------------------------
      Check the Appropriate Box if a Member of a Group*
 2    (a) [_]
      (b) [_]
                                                 
- ------------------------------------------------------------------------------
      SEC Use Only
 3
 
- ------------------------------------------------------------------------------
      Source of Funds: AF
 4    
      
- ------------------------------------------------------------------------------
       
 5    [_] Check if Disclosure of Legal Proceedings is Required Pursuant to 
          Items 2(d) or 2(e)

- ------------------------------------------------------------------------------
      Citizenship or Place of Organization: CALIFORNIA
 6  
      
- ------------------------------------------------------------------------------

                         Sole Voting Power
                     7   
     Number of           SEE FOOTNOTE 2 BELOW
 
    Partnership    -----------------------------------------------------------
                         Shared Voting Power
     Interests
                     8   SEE FOOTNOTE 2 BELOW
   Beneficially   
                   -----------------------------------------------------------
     Owned by            Sole Dispositive Power
                     9    
       Each              SEE FOOTNOTE 2 BELOW
                  
    Reporting      -----------------------------------------------------------
                     10  Shared Dispositive Power
      Person               
                         SEE FOOTNOTE 2 BELOW
       With        

- ------------------------------------------------------------------------------
      Aggregate Amount Beneficially Owned by Each Reporting Person:
 11 
      3,200 Class A Limited Partnership Interests/2/

- ------------------------------------------------------------------------------
      
12   [_]   Check if the Aggregate Amount in Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------
      Percent of Class Represented by amount in Row (11): 100%
13    

- ------------------------------------------------------------------------------
      Type of Reporting Person* CO
14

- ------------------------------------------------------------------------------

______________________

/2/ ALZA Development Corporation, a wholly owned subsidiary of ALZA Corporation
and the general partner of the Issuer, has consummated the exercise of its
purchase option with respect to all of the outstanding limited partnership
interests of the Issuer (consisting of 3,200 Class A Limited Partnership
Interests and one Class B Limited Partnership Interest) under the Agreement of
Limited Partnership of the Issuer, as amended. ALZA Development Corporation owns
all of the limited partnership interests of the Issuer. See Item 1.
<PAGE>
 
                                                            PAGE 3 OF 5 PAGES

- ------------------------------------------------------------------------------
      Name of Reporting Persons and 
 1    S.S. or I.R.S. Identification No. 
      ALZA CORPORATION
      I.R.S. Identification No.: 77-0142070

- ------------------------------------------------------------------------------
      Check the Appropriate Box if a Member of a Group*
 2    (a) [_]
      (b) [_]
                                                 
- ------------------------------------------------------------------------------
      SEC Use Only
 3 
 
- ------------------------------------------------------------------------------
      Source of Funds: WC
 4    
      
- ------------------------------------------------------------------------------
       
 5    [_] Check if Disclosure of Legal Proceedings is Required Pursuant to 
          Items 2(d) or 2(e)

- ------------------------------------------------------------------------------
      Citizenship or Place of Organization: DELAWARE
 6  
      
- ------------------------------------------------------------------------------

                         Sole Voting Power
                    7    
     Number of           SEE FOOTNOTE 2 BELOW
 
    Partnership    -----------------------------------------------------------
                         Shared Voting Power
     Interests
                    8    SEE FOOTNOTE 2 BELOW
   Beneficially   
                   -----------------------------------------------------------
     Owned by            Sole Dispositive Power
                    9     
       Each              SEE FOOTNOTE 2 BELOW
                  
    Reporting      -----------------------------------------------------------
                    10   Shared Dispositive Power
      Person               
                         SEE FOOTNOTE 2 BELOW
       With        

- ------------------------------------------------------------------------------
      Aggregate Amount Beneficially Owned by Each Reporting Person:
 11 
      3,200 Class A Limited Partnership Interests/2/

- ------------------------------------------------------------------------------
      
 12  [_]   Check if the Aggregate Amount in Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------
      Percent of Class Represented by amount in Row (11): 100%
 13   

- ------------------------------------------------------------------------------
      Type of Reporting Person* CO
 14

- ------------------------------------------------------------------------------

______________________

/2/ ALZA Development Corporation, a wholly owned subsidiary of ALZA Corporation
and the general partner of the Issuer, has consummated the exercise of its
purchase option with respect to all of the outstanding limited partnership
interests of the Issuer (consisting of 3,200 Class A Limited Partnership
Interests and one Class B Limited Partnership Interest) under the Agreement of
Limited Partnership of the Issuer, as amended. ALZA Development Corporation owns
all of the limited partnership interests of the Issuer. See Item 1.
<PAGE>
 
                                                               PAGE 4 OF 5 PAGES
 
Item 1.   Security and Issuer.
          ------------------- 

          This Statement is the first amendment to the statement on Schedule 13D
dated July 6, 1998 relating to the Class A Limited Partnership Interests of ALZA
TTS Research Partners, Ltd., a California limited partnership (the "Issuer").

          On August 14, 1998 (the "Closing Date"), ALZA Development Corporation,
a California corporation ("ADC"), consummated the purchase of all of the
outstanding Class A Limited Partnership Interests and the Class B Limited
Partnership Interest (together, the "Limited Partnership Interests") of the
Issuer through the exercise of its purchase option pursuant to the terms of the
Agreement of Limited Partnership dated December 30, 1982, as amended. ADC is the
general partner of the Issuer and a wholly owned subsidiary of ALZA Corporation,
a Delaware corporation. Accordingly, ADC now owns all of the Limited Partnership
Interests.
<PAGE>
 
                                                               PAGE 5 OF 5 PAGES

                                   SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this Statement is true, complete and
correct.

Dated: August 14, 1998

                              ALZA DEVELOPMENT CORPORATION



                              By:  /s/ David R. Hoffmann
                                   ___________________________________________
                                   David R. Hoffmann
                                   President and
                                   Chief Financial Officer


                              ALZA CORPORATION



                              By:  /s/ Bruce C. Cozadd
                                   ___________________________________________
                                   Bruce C. Cozadd, Senior Vice President and
                                   Chief Financial Officer


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