MEDCHEM PRODUCTS INC /MA/
10-Q, 1995-08-09
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549
                                   FORM 10-Q


(Mark One)

      X       Quarterly Report pursuant to Section 13 or 15(d) of
------------  the Securities Exchange Act of 1934

For Quarterly period ended         June 30, 1995              or
                           ----------------------------------   

              Transition report pursuant to Section 13 or 15(d) of
------------                                                      
the Securities Exchange Act of 1934


Commission File Number        1-9899
                       --------------------------

                            MedChem Products, Inc.
-------------------------------------------------------------------------------
            (Exact name of registrant as specified in its charter)

    Massachusetts                                         04-2471310  
-------------------------------------------------------------------------------
(state or other jurisdiction of                        (I.R.S. Employer
 incorporation or organization)                        Identification No.)

    232 West Cummings Park, Woburn, MA.                     01801          
-------------------------------------------------------------------------------
(Address of principal executive offices)                  (Zip Code)

Registrant's telephone number, including area code (617) 932-5900
                                                   ---------------

-------------------------------------------------------------------------------
(Former name, former address and former fiscal year, if changed since last
report.)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days.

                           Yes   X       No 
                               -----        -----     


                     APPLICABLE ONLY TO CORPORATE ISSUERS:

Indicate the number of shares outstanding of each of the issuer's classes of
common stock, as of the latest practicable date.

On August 1, 1995, 10,306,096 shares of common stock, par value $0.01 per share,
were outstanding.

                                       1

<PAGE>
 
PART 1:  FINANCIAL  INFORMATION
ITEM 1:  FINANCIAL  STATEMENTS



MEDCHEM PRODUCTS, INC. AND SUBSIDIARIES
<TABLE> 
<CAPTION> 
Consolidated Balance Sheets as of,                                   June 30, 1995          December 31, 1994
-------------------------------------------------------------------------------------------------------------- 
<S>                                                                  <C>                    <C> 
ASSETS

Current assets:
  Cash and cash equivalents                                             $1,335,019                   $157,591
  Cash escrow agreement                                                  2,000,000                         --
  Accounts receivable                                                    4,429,211                  4,032,487
  Inventories                                                            9,347,004                 10,739,786
  Note receivable -Anika Research, Inc.                                  1,000,000                         --
  Prepaid expenses and other current assets                              1,809,338                  1,494,811
-------------------------------------------------------------------------------------------------------------- 
          Total current assets                                          19,920,572                 16,424,675
-------------------------------------------------------------------------------------------------------------- 

Property, plant and equipment                                           13,578,144                 12,466,151
Less accumulated depreciation and amortization                           3,405,526                  3,021,975
-------------------------------------------------------------------------------------------------------------- 
          Net property, plant and equipment                             10,172,618                  9,444,176
-------------------------------------------------------------------------------------------------------------- 

Note receivable -Anika Research, Inc.                                           --                  1,000,000
Cost in excess of net assets of businesses acquired                     35,256,151                 35,887,747
Intangible and other assets                                             15,681,448                 16,274,010
-------------------------------------------------------------------------------------------------------------- 
          Total Assets                                                 $81,030,789                $79,030,608
============================================================================================================== 

LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
  Accounts payable                                                      $1,386,953                 $2,679,607
  Accrued expenses                                                       2,969,416                  3,370,893
  Note payable - Life Medical Sciences, Inc.                                    --                  1,000,000
  Current installments of long term debt                                 2,000,000                  2,000,000
-------------------------------------------------------------------------------------------------------------- 
          Total current liabilities                                      6,356,369                  9,050,500
-------------------------------------------------------------------------------------------------------------- 

Deferred income taxes                                                      577,229                    626,809
Long-term debt, excluding current installments                          13,350,000                 11,000,000
Convertible subordinated debt                                            4,103,204                  4,103,204
-------------------------------------------------------------------------------------------------------------- 
          Total liabilities                                             24,386,802                 24,780,513
-------------------------------------------------------------------------------------------------------------- 

Stockholders' equity:
  Preferred stock, $.01 par value: authorized 1,000,000
    shares; no shares issued and outstanding                                    --                         --
  Common stock, $.01 par value: authorized
    20,000,000 shares; issued 11,304,548 and 11,213,536
    shares, respectively                                                   113,045                    112,135
  Additional paid-in capital                                            37,905,803                 37,493,085
  Retained earnings                                                     27,200,281                 25,220,017
-------------------------------------------------------------------------------------------------------------- 
                                                                        65,219,129                 62,825,237
  Treasury stock, 1,024,702 shares, at cost                             (8,575,142)                (8,575,142)
-------------------------------------------------------------------------------------------------------------- 
          Total stockholders' equity                                    56,643,987                 54,250,095
-------------------------------------------------------------------------------------------------------------- 
          Total Liabilities and Stockholders' Equity                   $81,030,789                $79,030,608
==============================================================================================================
</TABLE> 
See accompanying notes to consolidated financial statements.



                                 2
<PAGE>
 
MEDCHEM  PRODUCTS,  INC.  AND  SUBSIDIARIES
Consolidated Statements of Operations  
<TABLE> 
<CAPTION> 
                                                                 Three months ended                          Six months ended
                                                                      June 30,                                   June 30,
                                                                1995                1994                  1995                1994
---------------------------------------------------------------------------------------------------------------------------------- 
<S>                                                       <C>                 <C>                  <C>                 <C> 
Net sales                                                 $9,822,717          $6,926,324           $19,243,987         $14,859,834
                                                                                                                   
Cost of sales                                              3,162,777           2,118,964             6,181,815           4,657,687
---------------------------------------------------------------------------------------------------------------------------------- 
                 Gross profit                              6,659,940           4,807,360            13,062,172          10,202,147
                                                                                                                   
Operating expenses:                                                                                                
    Research and development                                 511,681             302,937             1,114,433             481,118
    Selling, general and administrative                    3,355,940           2,426,770             6,966,176           5,284,253
    Depreciation and amortization                            669,108             608,147             1,315,895           1,218,802
    Other (reorganization costs)                                  --             510,000                    --             510,000
---------------------------------------------------------------------------------------------------------------------------------- 
                 Total operating expenses                  4,536,729           3,847,854             9,396,504           7,494,173
                                                                                                                   
Income from operations before interest and income taxes    2,123,211             959,506             3,665,668           2,707,974
Interest expense, net                                        395,402             241,404               773,913             489,107
----------------------------------------------------------------------------------------------------------------------------------
                                                                                                                    
Income from operations before income taxes                 1,727,809             718,102             2,891,755           2,218,867
Income tax expense                                           552,898             199,793               911,491             617,422
---------------------------------------------------------------------------------------------------------------------------------- 
                 Net income                               $1,174,911            $518,309            $1,980,264          $1,601,445
                                                                                                                   
                                                                                                                   
Income per share, primary and fully diluted:                   $0.11               $0.05                 $0.19               $0.16
                                                                                                                   
Weighted average number of shares outstanding:                                                                     
        Primary                                           10,699,000          10,305,000            10,523,000          10,305,000
        Fully diluted                                     10,932,000          10,305,000            10,641,000          10,305,000
---------------------------------------------------------------------------------------------------------------------------------- 
</TABLE> 
See accompanying notes to consolidated financial statements.


                                       3
<PAGE>
 
MEDCHEM  PRODUCTS,  INC.  AND  SUBSIDIARIES
Consolidated Statements of Cash Flows
<TABLE> 
<CAPTION> 
                                                                                            Six months ended June 30,

                                                                                               1995             1994
------------------------------------------------------------------------------------------------------------------------ 
<S>                                                                                      <C>                 <C> 
Cash flows from operating activities:
          Net income                                                                     $1,980,264          $1,601,445
          Adjustments to reconcile net income to net cash
             provided by operating activities:
             Depreciation and amortization                                                1,703,525           1,701,100
             Deferred income taxes                                                          (49,580)         (1,374,760)
             Changes in operating assets and liabilities:
                   Accounts receivable                                                     (396,724)            395,817
                   Inventories                                                            1,392,782          (1,672,947)
                   Prepaid expenses and other current assets                               (314,527)            445,325
                   Other assets                                                             (95,815)            (26,840)
                   Accounts payable and accrued expenses                                 (1,694,131)            731,120
------------------------------------------------------------------------------------------------------------------------ 
                      Net cash provided by operating activities                           2,525,794           1,800,260
------------------------------------------------------------------------------------------------------------------------ 

Cash flows from investing activities:
         Additions to property, plant and equipment                                      (1,111,994)         (1,087,869)
------------------------------------------------------------------------------------------------------------------------ 
                      Net cash used for investing activities                             (1,111,994)         (1,087,869)
------------------------------------------------------------------------------------------------------------------------ 

Cash flows from financing activities:
         Cash in escrow agreement                                                        (2,000,000)                 --
         Net borrowing  (payments) under revolving line of credit                         3,350,000            (600,000)
         Principal payments on bank debt                                                 (1,000,000)                 --
         Principal payment on note payable - Life Medical Sciences, Inc.                 (1,000,000)                 --
         Proceeds from exercise of stock options                                            413,628              11,571
------------------------------------------------------------------------------------------------------------------------ 
                      Net cash used by financing activities                                (236,372)           (588,429)
------------------------------------------------------------------------------------------------------------------------ 

                      Increase in cash  and cash equivalents                              1,177,428             123,962
Cash and cash equivalents  at beginning of period                                           157,591              (5,375)
------------------------------------------------------------------------------------------------------------------------ 
Cash and cash equivalents  at end of period                                              $1,335,019            $118,587
======================================================================================================================== 
Supplemental disclosure of cash flow information:
         Cash paid for:
                   Interest                                                                $675,534            $469,278
                   Income taxes                                                             578,412           1,607,221
------------------------------------------------------------------------------------------------------------------------ 
</TABLE> 
See accompanying notes to consolidated financial statements.

                                       4
<PAGE>
 
PART I:   FINANCIAL INFORMATION

                    MEDCHEM PRODUCTS, INC. AND SUBSIDIARIES
                   Notes to Consolidated Financial Statements
                   ------------------------------------------
                                  June 30,1995
(1)  Nature of Business
     ------------------

     MedChem Products, Inc. and subsidiaries ("the Company") develop,
     manufacture and market specialty medical products for use in surgical and
     non-surgical procedures.  The Company's two business groups are the
     Surgical Specialties Group and the Drug Delivery Group.  The Surgical
     Specialties Group is comprised of the Company's Avitene(R) family of
     topical hemostasis products used to control bleeding in surgical procedures
     and the Sure-Closure product line, acquired in July 1994, used to close
     skin-deficit wounds.  The Drug Delivery Group is comprised of intravenous
     ("I.V")catheter products and disposable medical devices sold to the
     neonatal, pediatric and adult markets by the Company's wholly owned
     subsidiary, Gesco International, Inc. ("Gesco").

(2)  Basis of Presentation
     ---------------------

     The accompanying consolidated financial statements have been prepared by
     the Company without audit, pursuant to the rules and regulations of the
     Securities and Exchange Commission.  In the opinion of the Company, these
     consolidated financial statements contain all adjustments (consisting of
     only normal recurring adjustments) necessary to present fairly the
     consolidated financial position of the Company as of June 30, 1995 and the
     consolidated results of operations for the three months and six months
     ended June 30, 1995 and 1994 and consolidated cash flows for the six months
     ended June 30, 1995 and 1994.  The results of operations for the six months
     ended June 30, 1995 are not necessarily indicative of results to be
     expected for the full year.

     The accompanying consolidated financial statements and the related notes
     should be read in conjunction with the Company's annual financial
     statements filed with the Annual Report (Form 10-K) for the fiscal year
     ended August 31, 1994, and the Company's financial statements filed with
     the Transition Report (Form 10-Q) for the four months ended December 31,
     1994.

     The Company changed its fiscal year end from August 31, to December 31, and
     accordingly, has restated its prior period results to correspond to the new
     calendar period.

                                       5

<PAGE>
 
     Certain reclassifications were made to the 1994 consolidated financial
     statements to conform to the current year presentation.

(3)  Long-Term Debt
     --------------
 
     Long term debt consists of the following:
<TABLE> 
<CAPTION> 
                                                      June 30,   December 31,
                                                        1995         1994
                                                    ------------  ----------
<S>                                                 <C>          <C>  
$9,000,000 bank revolving line
of credit at the bank's prime
rate plus one quarter percent or 
cost of funds plus two and a quarter
percent (8.27% at June 30, 1995),
secured by tangible and
intangible property, payable
by June, 1997.                                      $ 7,350,000  $ 4,000,000
 
Term loan payable to a bank,
interest at the bank's prime
rate plus one-half of one
percent or LIBOR plus two percent
(8.27% at June 30, 1995)
payable in quarterly installments
of $500,000, with a final installment
of $4,500,000 on May 1, 1997,
secured by tangible and intangible
property.                                             8,000,000    9,000,000
                                                    -----------  -----------
                                               
Total long-term debt                                 15,350,000   13,000,000
                                               
Less: current installments                            2,000,000    2,000,000
                                                    -----------  -----------
 
Long-term debt
  less current installments                         $13,350,000  $11,000,000
                                                    ===========  ===========
</TABLE>

     At June 30, 1995, the Company obtained a waiver of a covenant pertaining to
     the ratio of indebtedness to net cash flow, and also reached an agreement
     with the bank to amend that covenant. It is probable that the Company will
     be in compliance with this amended covenant at the next measurement date.

(4)  Escrow Agreement
     ----------------

     On April 13, 1995, the Company paid $2,000,000 to an escrow account,
     pursuant to the terms and conditions of the Distribution Agreement, dated
     March 31, 1995, between the Company and Coletica, a Lyon, France based
     manufacturer of medical devices.


                                       6

<PAGE>
 
     Under terms of the distribution agreement the Company received an exclusive
     right to distribute Coletica's Hemostagene(R) collagen hemostatic sponge in
     the United States for five years.  The agreement also contains provisions
     for the extension of the term beyond five years upon the achievement of
     certain sales volume goals.

(5)  Merger Agreement
     ----------------

     On May 24, 1995, the Company announced that the Board of Directors had
     approved a definitive agreement for a stock-for-stock merger of the Company
     ("Merger") into C.R. Bard, Inc. ("Bard"). Under the terms of the agreement
     each MedChem share will be valued at $9.25, subject to adjustment under
     certain circumstances and will be exchanged for Bard shares. The
     transaction is expected to be a tax free reorganization and to be accounted
     for as a pooling of interests. Under certain circumstances, if a
     transaction does not occur, Bard has an option to purchase the Company's
     Gesco subsidiary ("Option").

     The Company has elected to defer its costs and expenses of the Merger until
     the transaction closes or it is terminated.  As of June 30, 1995 the
     Company has deferred $405,265 of costs associated with the Merger.


(6)  Contingencies
     -------------

     On August 1, 1995, Edward J. Borto, who may be a stockholder of the
     Company, filed a putative class action naming as defendants, the Company,
     members of the Company's Board of Directors ("Board") and Bard. The
     plaintiff alleges, among other things, that the Company and the members of
     the Company's Board breached their fiduciary duties to the Company's
     stockholders by agreeing to be acquired by Bard for grossly unfair and
     inadequate consideration and in a manner which is coercive and
     fundamentally unfair to the Company's stockholders. The complaint seeks
     declaratory relief, preliminary and permanent injunction of the Merger and
     the Option, unspecified compensatory damages and costs and disbursements.
     The Company believes that the claims asserted are without merit and plans
     to defend against them vigorously. However, the amount of exposure, the
     outcome, or its effect on the consummation of the Merger, cannot be
     predicted at this time.
     
                                       7
<PAGE>
 
     In December, 1994, the Internal Revenue Service (the "Service") selected
     MedChem (P.R.) Inc.'s 1992 tax return and its qualifications under 
     Section 936 for review. As a result of the review, the Service has
     initiated a request for technical advice from the National Office with
     respect to MedChem (P.R.), Inc.'s active conduct of a trade or business in
     Puerto Rico. The active conduct of a trade or business in Puerto Rico is a
     requirement of Section 936. Additionally, the Massachusetts Department of
     Revenue has selected for audit the Company's 1992 and 1993 state tax
     returns. At this time, the ultimate outcome of this review and audit cannot
     be predicted.

     The Company is currently involved in four pending product liability claims
     related to its Drug Delivery Group business. At this time the Company
     cannot estimate the exposure on its financial statements, if any, if the
     Company were unsuccessful in its defense of these claims.

                                       8
<PAGE>
 
PART I:   FINANCIAL INFORMATION

Item 2:   Management's Discussion and Analysis of Financial
               Condition and Results of Operations

     Financial Overview
     ------------------

     The Company reported consolidated net income of $1,174,911, or $0.11 per
     share, for the second quarter ended June 30, 1995, versus consolidated net
     income of $518,309 or $0.05 per share, for the quarter ended June 30, 1994.
     For the first six months of 1995, net income was $1,980,264 or $0.19 per
     share versus $1,601,445 or $0.16 per share in the comparable period last
     year.

     On July 29, 1994, the Company purchased substantially all of the assets and
     assumed certain liabilities of the Sure-Closure product line from Life
     Medical Sciences, Inc ("L.M.S.").  The results of operations of the Sure-
     Closure product line since the date of acquisition have been included with
     those of the Company.

     On May 24, 1995, the Company announced that the Board of Directors had
     approved a definitive agreement for a stock-for-stock merger of the Company
     ("Merger") into C.R. Bard, Inc. ("Bard"). Under the terms of the agreement
     each MedChem share will be valued at $9.25, subject to adjustment under
     certain circumstances and will be exchanged for Bard shares. The
     transaction is expected to be a tax free reorganization and to be accounted
     for as a pooling of interests. Under certain circumstances, if a
     transaction does not occur, Bard has an option to purchase the Company's
     Gesco subsidiary ("Option").

     Results of Operations
     ---------------------

     Net sales for the three month period ended June 30, 1995 increased 42% to
     $9,822,717 from $6,926,324 in the comparable period last year.  During the
     second quarter of 1995, domestic sales increased 22% to $6,950,099 from
     $5,690,066 in the previous year's quarter. This increase was primarily due
     to sales generated by the recently acquired Sure-Closure product line.
     International sales for the three month period ended June 30, 1995
     increased 132% to $2,872,619 from $1,236,258 in the comparable quarter in
     1994, primarily due to increased sales to the Company's Avitene partner in
     Japan.

     Net sales for the first six months of 1995 increased by $4,384,153 or 30%
     to $19,243,987 from $14,859,834 in the corresponding period in the prior
     year.  During the first half of 1995, domestic sales increased 15% to
     $14,332,907 from $12,453,342 in the comparable period in the prior year.
     This increase was primarily due to sales generated by the recently acquired
     Sure-Closure product line and increased sales from the Company's Gesco
     subsidiary.  International sales for the first six months of 1995 increased
     by $2,504,589 or 104% to

                                       9
<PAGE>
 
     $4,911,081 from $2,406,492 in the first six months of 1994, primarily due
     to increased sales to the Company's Avitene partner in Japan.  In the first
     half of 1994, international sales were depressed due to the overstocking
     position at the Company's Avitene partner in Japan which were previously
     disclosed and rectified in calendar 1994.  The Company anticipates an
     overall increase in total international sales in calendar 1995 as compared
     to 1994 primarily due to increased sales volume and more favorable exchange
     rates.

     Gross profit, as a percentage of net sales, for the three and six months
     ended June 30, 1995, each decreased to 68% from 69% in the comparable
     periods last year.

     Research and development expense (which includes regulatory and clinical
     trial expenses) increased to $511,681 and $1,114,433 for the three and six
     month periods ended June 30, 1995, respectively, from $302,937 and $481,118
     in the prior year due mainly to the research and development being
     conducted in connection with the Sure-Closure product line and increased
     product development related to the Company's Drug Delivery Group products.
     The Company expects an increase in research and development expenses for
     the full 1995 year as compared to 1994 due to the addition of the Sure-
     Closure product line and increased product development related to its Drug
     Delivery Group product line.

     Selling, general and administrative expenses increased by $929,170 to
     $3,355,940 for the three month period ended June 30, 1995 from $2,426,770
     in the prior year.  For the first six months of 1995, selling, general and
     administrative expenses increased by $1,681,923 to $6,966,176 from
     $5,284,253 in the comparable period in the prior year. The increase is
     attributable to higher Surgical Specialty sales force selling and marketing
     expenses resulting from the addition of the Sure-Closure product line and
     increased corporate administrative expenses. The Company expects no
     significant increase in selling, general and administrative expenses as a
     percentage of net sales for 1995 as compared to 1994.

     Depreciation and amortization expense for the three and six months ended
     June 30, 1995 totalled $669,108 and $1,315,895, respectively, compared to
     $608,147 and $1,218,802 in the comparable periods in the prior year.

     The Company recorded net interest expense for the three and six month
     periods ended June 30, 1995 of $395,402 and $773,913 versus $199,793 and
     $617,422 for the comparable periods in 1994.  The increase in interest
     expense for the first half of 1995 versus 1994 was due to higher interest
     rates and increased debt borrowing.

     The Company's effective tax rate for the three month and six months 
     ended June 30, 1995, each increased to 32% from 28% in the

                                      10

<PAGE>
 
     comparable period last year. The increase was due to the recently enacted
     changes to Section 936 which reduced the tax benefit to the Company. The
     Company anticipates its effective tax rate will increase to the statutory
     rate during the year as the Company completes the move of its Avitene
     finished goods manufacturing to the United States, as previously disclosed,
     and accordingly, loses its tax benefit under Section 936.
     

     Liquidity and Capital Resources
     -------------------------------

     The Company generated net cash from operating activities of $2,525,794 in
     the first half of 1995 versus $1,800,260 in the comparable period last
     year.
 
     At June 30, 1995, the Company had a revolving line of credit agreement
     whereby the bank will lend the Company up to $9,000,000 at the bank's prime
     rate plus a quarter percent or cost of funds rate plus two and one quarter
     percent and a $10,000,000 term loan.  At June 30, 1995 there was $7,350,000
     outstanding under this line and $8,000,000 outstanding under the term loan.
     The line of credit expires in June 1997 and the $10,000,000 term loan is
     payable to the bank in quarterly installments of $500,000 through 1997,
     with a final payment of $4,500,000 due on May 1, 1997.

     The $4,103,204 of convertible subordinated debt issued to Gesco's principal
     sellers is convertible at the option of the holders into common stock at
     $11.73 per share.  The note can be prepaid in whole, but not in part, at
     par at the Company's option, and is payable in full on August 4, 1997.

     In connection with the purchase of the Sure-Closure product line, the
     Company issued a non-interest bearing note payable to L.M.S. in the
     principal amount of $2,000,000.  The first installment of $1,000,000 and
     the last installment of $1,000,000 were paid on October 27, 1994 and
     January 27, 1995 respectively.

     The Company believes that cash flow generated from its operating
     activities, as well as funds available under its bank line of credit, will
     be sufficient to enable the Company to conduct its operations and repay its
     indebtedness.

                                      11


<PAGE>
 
PART II:  OTHER INFORMATION
          -----------------



Item 6:   Exhibits and Reports on Form 8-K

(a)  Exhibit No.          Description
     -----------          -----------

 
        10.1         Raw Material Contract
                     Edible Bovine Corium
                     dated April 18, 1995
        
        10.2         Sixth Amendment to Revolving Credit and Term
                     Financing dated April 14, 1995.
        
        10.3         Amendment to Timothy Patrick's Employment Agreement.
        
        11           Computation of earnings per
                     share.
        
        27           Financial Data Schedule.




(b)  Reports on Form 8-K
     -------------------
 
     On June 7, 1995, the Company filed a current report on Form 8-K dated May
     24, 1995 reporting the execution and delivery of an agreement and plan of
     merger among C.R. Bard, Inc., CRB Acquisition Corp., and the Company.

                                      12

<PAGE>
 
                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



                            MEDCHEM PRODUCTS, INC.



     DATE:  August 9, 1995          BY:/s/ Edward J. Quilty
                                       -----------------------------            
                                    Edward J. Quilty
                                    President
                                    Chief Executive Officer



     DATE:  August 9, 1995          BY:/s/ John J. McDonough
                                       ----------------------------             
                                    John J. McDonough
                                    Vice President
                                    Chief Financial Officer



                                      13


<PAGE>
 
                             RAW MATERIAL CONTRACT
                             EDIBLE BOVINE CORIUM
                           MedChem Part No. 100-016
                                April 18, 1995


The Lackawanna Leather Company, a division of United States Leather, Inc., 2420
Z Street, Omaha, Nebraska, 68107, hereinafter called "Seller", agrees to sell,
and MedChem Products, Inc., 232 West Cummings Park, Woburn, Massachusetts,
01801, hereinafter called "Buyer", agrees to buy, the following described
product subject to the terms and conditions herein set forth:

I.   PRODUCT
     -------

     Edible Bovine Corium obtained from cattle with an origin in the United
     States of America and an XXX XXXXXXXXX XXXXX XX XXXXX XX XX XXXX XXXX XXXX
     XXXXX. of extract made in accordance to Buyer's procedure DCN 94-022 for
     Edible Bovine Corium, as set forth on Exhibit A attached hereto, which
     shall be separately acknowledged and agreed to by each, the Seller and
     Buyer (the "Specifications".)

II.  WARRANTY
     --------

     Seller warrants that the product delivered hereunder shall meet all
     Specifications, shall be produced in accordance with applicable GMP's and
     all other procedures identified by Buyer (pursuant to Article VIII 10) and
     shall be free of liens and encumbrances.  This is the sole warranty
     provided by Seller and Buyer acknowledges that Seller hereby disclaims any
     implied warranties under the Uniform Commercial Code.

III. LIMITATION OF LIABILITY
     -----------------------

     Notwithstanding anything to the contrary contained herein and solely as it
     applies to pyrogen specification, Seller shall not be liable to Buyer for
     failing to produce products which meet the pyrogen specification identified
     on Exhibit A so long as the failure to meet such specification does not
     result from Seller's failure to meet all Specifications or to produce the
     product in accordance with applicable GMP's and all other procedures
     identified by Buyer (pursuant to Article VIII 10).  In the event that Buyer
     does not accept product because such product does not meet the pyrogen
     specification, Buyer shall be liable to Seller for the invoice cost of the
     hides purchased and used to make such product.


(X) Confidential material omitted and filed separately with the Securities and 
    Exchange Commission.

<PAGE>
 
IV.  PRICE AND QUANTITY
     ------------------

     1.   Subject to the terms of this Agreement, Buyer agrees to purchase and
          Seller agrees to furnish an aggregate of XXXXXX pounds of product over
          the course of this contract.  Additional quantity is negotiable upon
          Seller's ability to produce more product, and Buyer's desire to
          purchase a greater quantity.

          For the  purposes of this agreement, all weights refer to wet Edible
          Bovine Corium weight at the time of packaging at the Seller's Omaha,
          Nebraska, facility.

     2.   Delivery schedule is defined in Article VI below.

     3.   Price per pound is:

                XXXXXX   per pound
                 XXXXX   per pound payback of advance for start-up costs
                ------                                                   
                XXXXXX   per pound net price.

     4.   Start-up costs of XXXXXXX will be advanced to the Seller by the later
          of (i) 30 days after notice of the equipment renovation and (ii) 15
          days after the date buyer receives an invoice for such advance.
          During the start-up, the Seller will replace an existing Challenge
          Mixer with a stainless steel mixer that is currently owned by the
          Seller.

          Title to the new stainless steel mixer will pass to the Buyer after
          installation free and clear of encumbrances.  Title to the existing
          Challenge Mixer will pass to the Seller, free and clear of
          encumbrances.

          Seller shall pay back the advance of XXXXXXX by crediting the Buyer
          with XXXXX per pound for each pound sold hereby as shown in Paragraph
          3 above.

          Up front start-up costs for which the advance may be used shall
          include the following:
<TABLE>
          <S>                                                      <C>
          - Lease and install Reverse Osmosis Pure Water System    XXXXXXX.XX
          - Trade Challenge Mixer for stainless steel mixer          XXXXX.XX
          - Splitting machine servicing                              XXXXX.XX
          - Cleaning and painting materials                          XXXXX.XX
          - Cleaning and painting labor(80 hrs @ XXXXXXXX)             XXX.XX
          - Freezer and air conditioner start-up                       XXX.XX
          - Calibration of temperature recorders                       XXX.XX
                                                                   ----------
                                                                   XXXXXXX.XX  
</TABLE>

(X) Confidential material omitted and filed separately with the Securities and 
    Exchange Commission.

                                       2
<PAGE>
 
     5.   The price per pound includes and Seller shall pay, all excise, sales,
          use, transfer or other taxes, federal, state and local, in connection
          with the sales or delivery of the product to Buyer.

V.   TITLE OF EQUIPMENT
     ------------------

     All equipment purchased with the advance shall be retained by Buyer as its
     property.  Buyer recognizes that Seller may use this equipment during the
     term of this Agreement for processing and products for other customers.
     However, the Seller must obtain prior written approval from the Buyer for
     each use.  Seller hereby agrees to maintain this equipment in serviceable
     condition during each use.

VI.  DELIVERY SCHEDULE AND TERMS OF PAYMENT
     --------------------------------------

     Each lot of product must meet acceptable Quality Control inspection
     criteria of the Buyer before being transferred from the Seller's Omaha,
     Nebraska location to the Massachusetts cold storage location.

     Seller Will:

     1.   Deliver a XXX pound sample lot to Buyer on or before July 15, 1995.
          The purpose of this shipment is to verify that the product is able to
          be processed into flour at Buyer's manufacturing facility at Woburn,
          Massachusetts.

     2.   Deliver XXXXX pounds to the Massachusetts cold storage facility by
          August 31, 1995.  Deliver the remaining XXXXXX pounds on or before
          December 31, 1995.

     3.   a.   Seller will also invoice Buyer on a monthly basis and Buyer
               will pay such invoices within 15 days from the date that the
               Buyer receives Seller's invoices; Invoices shall be as of the 1st
               of the month as sent by Seller as follows:

               i.   For the eight (8) month period August 1995 through March
                    1996 invoiced at the rate of XXXX pounds per month.

               ii.  For the twenty (20) month period April 1996 through November
                    1997 at the rate of XXX pounds per month.

          b.   Unless the parties agree otherwise in writing, Seller must
               deliver the exact quantities specified (plus or minus 1%).  Buyer
               reserves the right to reject incomplete deliveries and to return
               at Seller's risk and expense excess quantities delivered.

(X) Confidential material omitted and filed separately with the Securities and 
    Exchange Commission.



                                       3
<PAGE>
 
          c.   Buyer's production and marketing schedules are established in
               part in reliance upon the delivery information specified in this
               Agreement.  If delivery cannot be made at the specified time and
               place, Seller shall promptly notify Buyer of the earliest
               possible date for a conforming delivery.  Notwithstanding such
               notice, and unless otherwise agreed by Buyer in writing, Seller's
               failure to effect a conforming delivery shall entitle Buyer to
               revoke any acceptance, to terminate the Agreement without
               liability to Seller, to receive a full refund on any amount paid
               with respect to such shipment, to purchase substitute products
               elsewhere, to return at Seller's risk and expense all or any part
               of a nonconforming delivery and to hold Seller accountable for
               any loss or additional costs incurred.

               Buyer's receipt of acceptance of all or a part of a nonconforming
               delivery shall not constitute a waiver of any claim, right or
               remedy under the Agreement or under applicable law.

VII. SERVICES TO BE PROVIDED BY SELLER AT SELLER'S EXPENSE
     -----------------------------------------------------

     1.   Appropriate clean facility satisfying GMP to conduct production.

     2.   Obtaining hides.

     3.   Processing hides.

     4.   Quality Control services by a sub-contractor approved by Buyer.

     5.   Training of Seller's work force.

     6.   Hiring of all labor and support people to manage the activity.

     7.   Setup and maintenance support for equipment to include calibrations.

     8.   Temporary cold storage of product at:

          - Omaha, Nebraska

          Temperature will be monitored and recorded. Temperature to be
          maintained in the range of -20 degrees F to +10 degrees F (monitoring
          specifications are attached hereto in Appendix A).

     9.   Supplying pure water through a leased Reverse Osmosis System.

     10.  Disposal of all waste in accordance with governmental and industry
     regulations.

                                       4
<PAGE>
 
     11.  Freight charges to deliver product to Massachusetts cold storage 
          facility (monitoring specifications are attached hereto in 
          Appendix A).

     12.  Insure product for loss while in transit.


VIII.  GENERAL TERMS
       -------------

     1.   Seller will identify each container of Edible Bovine Corium with the
          gross weight of the contents of the container, MedChem Part number
          100-016 and Lot #_____.  All products shall be packaged, marked and
          otherwise prepared for shipment by Seller in suitable containers in
          conformity with reasonable commercial practices.  Seller shall mark on
          containers all necessary handling, loading and shipping instructions.
          An itemized packing list shall be included with each shipment.

     2.   Seller will provide a certificate of origin with each Lot # delivered
          to Buyer.  This certificate will verify that the cattle, from which
          the product was harvested, had an origin in the United States of
          America.

     3.   For the term of the contract, arrangement and cost of refrigerated
          transportation of the product to the storage facility at Crystal Cold
          Storage and Warehouse, Inc., 25 Sycamore Avenue, Medford,
          Massachusetts, 02155, will be the responsibility of the Seller.
          Temperature will be monitored in transit and will be maintained
          between -20 degrees F and +10 degrees F (monitoring specification as
          attached hereto in Appendix A).

     4.   Title to product sold hereunder shall pass to Buyer upon delivery by
          Seller of conforming product and acceptance by Buyer at Crystal Cold
          Storage and Warehouse.

     5.   Seller agrees that Buyer, its agents and representatives, including
          but not limited to, Buyer's insurance representatives and
          underwriters, may inspect Seller's Omaha, Nebraska premises in a
          reasonable manner, with reasonable frequency, and for reasonable
          periods of time, for the purpose of monitoring the manufacture of the
          product and compliance with the terms of the Agreement and, for the
          purpose of rendering insurance advice to the Buyer in connection with
          this Agreement.

                                       5
<PAGE>
 
     6.   All products shall be received subject to Buyer's inspection, testing,
          and approval at Seller's premises, and subject to Buyers's acceptance
          of such products at Crystal Cold Storage and Warehouse after
          inspection and testing of the conditions of such products after
          shipping, notwithstanding any prior payment for such products.  The
          test, lab and any other inspection data;recorder data during initial
          testing, warehousing and transit will be provided to Seller by Buyer
          to perfect Buyer's claim for product rejected by Buyer upon inspection
          and testing at the Crystal Cold Storage and Warehouse.

          Upon a rejection of such a shipment and notice of said rejection by
          Buyer to Seller it shall be Seller's responsibility to adjust its
          production schedule to replace such rejected product within the
          delivery parameters specified under Article VI 3.  Products rejected
          by Buyer as not conforming to the Specifications may be returned to
          Seller at Seller's risk and expense.

     7.   Seller's warranties under Article II of this Agreement shall survive
          any delivery, inspection, acceptance, payment or resale of the
          products and shall extend to Buyer and its customers.  Following such
          delivery, inspection, acceptance, payment or resale of such products
          and notwithstanding anything to the contrary set forth herein, Seller
          shall only be liable with respect to such products in connection with
          any breach of its warranties in Article II of this Agreement.  Seller
          shall indemnify and hold Buyer harmless against any and all claims,
          losses, liabilities, damages, costs or expenses, including attorneys'
          fees and court costs, resulting from the breach of Seller's Article II
          Warranty(s) under this Agreement.  Seller and Buyer shall each
          maintain with an insurance company or companies comprehensive general
          liability insurance (including product liability hereunder) in the
          minimum amount of $2,000,000.  Any amount owed to Seller by Buyer
          shall be subject to deduction for any set-off, counterclaim or
          indemnification right arising out of this Agreement.

     8.   Sellers' liability to Buyer for breach of warranty or otherwise shall
          not include any incidental or consequential damages.

     9.   Notwithstanding anything to the contrary contained in this agreement,
          neither party will be liable for any default, damages or expenses
          under this agreement as a result of such party's failure to perform
          its duties under this Agreement, due to interruptions of the supply of
          raw materials, complete or partial destruction of the
          manufacturing/processing facilities, labor disputes and other matters
          reasonably beyond the control of either party; provided, however, that
          the party claiming the foregoing shall make a good faith effort to
          remedy any of the above contingencies. In such event, the time for
          performance shall be extended for the period of delay or inability to
          perform due to such event. During any period of shortage, Seller's
          first obligation will be to supply Buyer with its requirement as
          outlined in the PRICE AND QUANTITY section of this agreement.

                                       6
<PAGE>
 
     10.  The product will be manufactured in conformance with the
          Specifications.  However, the Buyer shall have the right to change the
          Specifications as reasonably desired by Buyer or as required by
          Federal regulations upon prior written notice to Seller provided that
          Buyer shall reimburse  Seller for any reasonable additional costs
          incurred by Seller in meeting such revised Specifications.  Seller may
          not make any changes in the Specifications without the prior written
          approval of the Buyer.

     11.  This agreement gives no license to Seller, either expressed or
          implied, under any patents, patent applications or other intellectual
          property of Buyer or under which Buyer has a right to grant licenses.

     12.  Seller acknowledges and agrees that all specifications, drawings,
          diagrams, schematics, sketches, models, samples, designs, technical
          information or data, written, oral or otherwise, furnished by Buyer to
          Seller is and shall remain Buyer's sole and exclusive property, and
          shall be returned promptly to Buyer upon the earlier of its request or
          the termination or completion of the agreement.  Seller acknowledges
          and agrees that all such intellectual and industrial property shall be
          treated as confidential and shall not be used or disclosed by Seller
          except under this Agreement.  Buyer further represents and warrants
          that the products delivered hereunder do not infringe any United
          States or foreign patent trademark, trade secret or copyright or any
          proprietary, intellectual property, industrial property, contract or
          other right held by any third party.

     13.  This agreement (other than the first two sentences of Section 12)
          shall terminate within  30   days after Seller has invoiced Buyer for
                                 -----                                         
          all of the product required to be delivered by this Agreement unless
          sooner terminated by Buyer and may be extended upon mutual agreement
          of the parties.  This agreement is not transferable nor assignable by
          Buyer or Seller without the prior written consent of the other party,
          but shall be binding upon and inure to the benefit of the parties
          hereto and their respective successors.

     14.  All notices to be provided hereunder shall be in writing, and shall be
          deemed given when addressed to a party hereto at the address set forth
          above, when deposited with the U.S. Mail, registered or certified, or
          when deposited with a nationally recognized overnight courier service.

     15.  This Agreement is to be governed by the laws of the State of Nebraska.

                                       7
<PAGE>
 
     16.  Termination:
          ------------

          (a)  Buyer may, by written notice to Seller, terminate the whole or
               any portion of this Agreement in the event of (i) proceedings,
               voluntary or involuntary, in bankruptcy or insolvency, by or
               against Seller, (ii) the appointment, with or without Seller's
               consent, of any trustee or receiver for any substantial portion
               of Seller's assets, (iii) any assignment for the benefit of
               Seller's creditors, or (iv) Sellers' breach of any provision
               contained herein; Provided that in the event of a breach by
               Seller of any provision contained herein, Seller shall have 30
               days from notice by Buyer to cure such breach and this Agreement
               shall only be terminable to the extent that such breach is not
               cured by such 30 day period.  In the event of any such
               termination, Buyer may procure, upon such terms and in such
               manner as it may deem appropriate, products comparable to the
               products covered by the Agreement so terminated, and Seller shall
               be liable to Buyer for any excess cost of such comparable
               products.  In the event of any such termination, Buyer may
               require Seller to deliver to it, in the manner and to the extent
               directed by it, any completed or partially completed products,
               against Buyer's payment of the portion of the price properly
               allocable to such products.  Seller shall continue performance of
               this Agreement to the extent not terminated.  Except to the
               extent specifically set forth herein, Buyer shall have no
               obligation or liability to Seller in respect of the terminated
               portion of this Agreement.  Notwithstanding the foregoing, Seller
               shall not be liable to Buyer for excess costs or other damages if
               Seller's default is due to a cause beyond its reasonable control
               and without its negligence.  Such notice shall be in writing and
               mailed by U.S. Mail addressed to the Seller, and the date of
               notice shall be the date of mailing.  In the event of any such
               termination, all deposits or prepayments shall be deemed to have
               been held in trust for Buyer's benefit and shall be returned to
               Buyer promptly upon request.

          (b)  Subject to Section 7 hereof, all of Seller's representation,
               warranties and indemnification obligations set forth in this
               Agreement shall survive the cancellation, termination or
               completion of this Agreement with respect to any product sold to
               Buyer prior to cancellation, termination or completion.

                                       8
<PAGE>
 
     17.  Compliance with Laws:
          ---------------------

          Seller shall comply with all applicable governmental laws, ordinances,
          codes, rules, regulations and orders in the performance of this
          Agreement, including, without limitation, the Occupational Safety and
          Health Act, the Fair Labor Standards Act of 1938, Title VII of the
          Civil Rights Act, the Age Discrimination in Employment Act, and
          Executive Order 11246, along with the implementing rules and
          regulations of the office of Federal Contracts Compliance.  At Buyer'
          request, Seller shall obtain all permits or licenses required in
          connection with the manufacture, sale, shipment and installation of
          the products ordered hereby.

     18.  Authorization:
          --------------

          Seller represents and warrants that it has been duly authorized to
          execute, deliver and perform this Agreement, and the person signing on
          Seller's behalf has the power and authority to do so.

     19.  Severability; Remedies; Waiver:
          -------------------------------

          In the event that any one or more provisions contained in this
          Agreement shall be held by a court of competent jurisdiction to be
          invalid, illegal or unenforceable in any respect, the validity,
          legality and enforceability of the remaining provisions contained
          herein shall not in any way be affected or impaired thereby.  The
          remedies contained herein are cumulative and in addition to any other
          remedies at law or equity.  Buyer's failure to enforce, or waiver of
          a breach of, any provision of this Agreement shall not constitute a
          waiver of any other breach of such provision.

     20.  Entire Agreement:
          -----------------

          This Agreement is the complete and exclusive statement of the contract
          between Buyer and Seller with respect to Buyer's purchase of the
          products.  No waiver, consent, modification, amendment or change of
          the terms of this Agreement shall be binding unless in writing and
          signed by Buyer and Seller.


All of the foregoing is accepted as of the date set forth above.

MEDCHEM PRODUCTS, INC.                     LACKAWANNA LEATHER

By:   /s/ Edward J. Quilty                 By:    /s/ Jeff Whitver
   ----------------------------------          -------------------------------

Date:                                      Date:  4/18/95
      -------------------------------            -----------------------------


                                       9

<PAGE>
 
                          SIXTH AMENDMENT TO REVOLVING
                          ----------------------------
                         CREDIT AND TERM LOAN AGREEMENT
                         ------------------------------


   THIS AGREEMENT (the "Amendment") is made as of the 14th day of April, 1995 by
and among MEDCHEM PRODUCTS, INC., (the "Parent") and its affiliates, MEDCHEM
(P.R.), INC. (f/k/a BioChem Products, Inc.) ("MedChem PR"), MEDCHEM SECURITIES
CORPORATION, MEDCHEM PRODUCTS FOREIGN SALES CORPORATION; and GESCO
INTERNATIONAL, INC. ("Gesco") (all of the foregoing, together with the Parent,
the "Borrowers"); and FLEET BANK OF MASSACHUSETTS, N.A. (the "Bank").

                                    RECITALS
                                    --------

   A.   The Bank and the Borrowers are parties to a Revolving Credit and Term
Loan Agreement dated as of July 31, 1992, as amended by the First, Second,
Third, Fourth and Fifth Amendments (as so amended, the "Loan Agreement").
Capitalized terms used herein without definition shall have the meanings
assigned to them in the Loan Agreement.

   B.   The Parent has entered into a Distribution Agreement (the "Distribution
Agreement") with Coletica, a French societe anonyme ("Coletica"), and an Escrow
Agreement (the "Escrow Agreement") with Coletica and Fleet Bank of Maine
("Escrow Agent"), each dated as of March 31, 1995.

   C.   The Borrowers have requested a $2,000,000 increase in the Commitment to
be used as the Deposit (as defined in and required by the Distribution
Agreement).

   D.   The Borrowers have also requested that the Bank issue a reducing standby
letter of credit for Borrowers' account in favor of its contract
manufacturer, Alcon, P.R.

   E.   Subject to certain terms and conditions, the Bank is willing to agree to
the same, as hereinafter set forth.

   NOW THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties hereto agree as
follows:

   1.   Amendments to Loan Agreement.
        ---------------------------- 

   The Loan Agreement is hereby amended as follows:

   (A) Exhibits.  Exhibit 1.2(a) to the Loan Agreement is deleted and new
       --------                                                          
Exhibit 1.2(a) attached hereto is substituted therefor (being an amended and
restated Revolving Note in the amount of $9,000,000).  Exhibit 3.15 to the Loan
Agreement is deleted and new Exhibit 3.15 attached hereto is substituted
therefor (being an updated patent, trademark, patent application and trademark
application list).
<PAGE>
 
   (B) Revolving Note Interest.  Section 1.4(a) of the Loan Agreement is amended
       -----------------------                                                  
by deleting it in its entirety and inserting in its place the following
language:

     "(a) Subject to the terms and conditions of subsection (c) of this Section,
   the Borrowers shall pay interest on the Revolving Loans outstanding from time
   to time at a rate per annum as follows:

                  (i)   the rate for any portion of each Revolving Loan which is
        not then subject to a Fixed Rate Option shall be the Prime Rate plus the
        Prime Rate Applicable Margin, which rate of interest shall change
        contemporaneously with any change in the Prime Rate.

                  (ii)  the rate for any LIBOR Portion shall be the applicable
        LIBOR Rate plus the Fixed Rate Applicable Margin.

                  (iii) the rate for any Cost of Funds Portion shall be the
        applicable Cost of Funds Rate plus the Fixed Rate Applicable Margin.

        For purposes of this Agreement, the term "Applicable Margin" shall mean:
                                                  -----------------             

                  (i)  from and after April 14, 1995 until the first Quarterly
        date, the Applicable Margin shall be 2.25%; and

                  (ii)  from and after June 30, 1995 and each Quarterly Date
        thereafter until the Expiration Date, the Applicable Margin shall be
        determined from the following table based upon the ratio of Indebtedness
        (excluding trade debt and accrued liabilities) on such Quarterly
        Date to Net Cash Flow for the four-quarter period ending on such
        Quarterly Date, based on the consolidated financial statements of the
        Borrowers provided under Section 4.1(a) and (c):
<TABLE>
<CAPTION>
 
Ratio of Indebtedness             Prime Rate          Fixed Rate
  to Net Cash Flow            Applicable Margin   Applicable Margin
---------------------         ------------------  ------------------
<S>                           <C>                 <C>
   Greater than 2.00:1.00            .25%               2.25%
 
   Less than or equal to
     2.00:1.00 and greater
     than 1.50:1.00                  -0-                2.00%
 
   Less than or equal to
     1.50:1.00                       -0-                1.75%
 
</TABLE>

                                      -2-
<PAGE>
 
        Notwithstanding the foregoing, no downward adjustment of the Applicable
   Margin hereunder shall be permitted (a) unless all of the financial
   statements for the relevant fiscal year have been delivered to the Bank as
   required in Section 4.1(a) and (c); and (b) if, as of the date of such
   proposed downward adjustment, there shall exist any Default."

   (C) Mandatory Commitment Reduction and Prepayments of Loans.  Section 1.16 of
       -------------------------------------------------------                  
the Loan Agreement is amended by changing the title thereof from "1.16 Mandatory
                                                                       ---------
Commitment Reduction and Prepayments of Term Loan." to "1.16 Mandatory
-------------------------------------------------            ---------
Prepayments of Loans." and by adding the following additional sentences at the
--------------------                                                          
end of said Section 1.16 as follows:

        "On the date the Parent is entitled pursuant to the terms of the Escrow
        Agreement to receive the escrow funds from the Escrow Agent: (a) the
        Commitment will automatically reduce to a $7,000,000, and (b) the
        Borrowers jointly and severally shall be required to prepay the
        outstanding balance of the Revolving Loans in such amount, if any,
        as is necessary to bring the principal amount thereof within the limits
        of the Commitment as so reduced, plus accrued and unpaid interest
        thereon. So long as the Commitment has not been permanently
        voluntarily reduced to $7,000,000 by the Borrowers, the Parent
        agrees that it shall not agree with Coletica to extend the "best
        efforts" date set forth in Section 2.5(c) of the Distribution Agreement
        for Premarket Approval (as defined in the Distribution Agreement)
        without the prior written consent of the Bank which consent shall not be
        unreasonably withheld."

   (D) Standby Letter of Credit.  A new Section 1.18 to the Loan Agreement is
       ------------------------                                              
added as follows:

        "1.18 Standby Letter of Credit.  Subject to the conditions to Loans set
              ------------------------                                         
        forth in Section 2 of the Loan Agreement, all of which must be met, and
        subject to the terms of the Bank's letter of credit application and
        agreement therefor, the Bank shall issue a standby letter of credit (the
        "Letter of Credit") for the account of the Borrowers for the benefit of
        Alcon, P.R. with an initial drawing amount of $765,912.58 which reduces
        to $665,912.58 on April 30, 1995, $465,912.58 on May 31, 1995,
        $265,912.58 on June 30, 1995 and -0- on July 31, 1995 when it shall
        terminate.  Each draw made on the Letter of Credit shall be due and
        payable jointly and severally by the Borrowers on the date of such draw.
        Unpaid draws shall accrue interest at the Revolving Loan default rate
        set forth in Section 1.4(c) hereunder.  A fee of 1.50% on the Letter of
        Credit shall be paid to the Bank upon its issuance.  All Obligations
        relating to

                                      -3-
<PAGE>
 
        the Letter of Credit shall be secured by all of the collateral now or
        hereafter granted under the Security Documents. Upon the termination of
        the Commitment or the acceleration of the Loans, in the event the Letter
        of Credit has not terminated by its terms, the Borrowers immediately
        shall jointly and severally pay to the Bank an amount equal to the then
        available drawing amount on the Letter of Credit to be held as cash
        collateral for the Borrowers' obligation to pay draws and other
        Obligations relating to the Letter of Credit."

   (E) Amended and New Definitions.  The following definitions in Section 8 of
       ---------------------------                                            
the Loan Agreement are amended or added to read as follows:

       "Applicable Margin":  See Section 1.4(a).
        -----------------                       

       "Commitment":  $9,000,000, subject to automatic reduction pursuant to
        ----------                                                          
   Section 1.16.

       "Letter of Credit":  See Section 1.18.
        ----------------                     

       "Quarterly Date":  March 31, June 30, September 30 and December 31.
        --------------                                                    

   2.   No Further Amendments.
        --------------------- 

   Except as specifically amended hereby, the Loan Agreement and the Security
Documents shall remain unmodified and in full force and effect and are hereby
ratified and affirmed in all respects, and the indebtedness of the Borrowers to
the Bank evidenced thereby and by the Notes is hereby reaffirmed in all
respects.

   3.   Certain Representations of the Borrowers.
        ---------------------------------------- 

   As a material inducement to the Bank to enter into this Amendment, each of
the Borrowers hereby represents and warrants to the Bank (which representations
and warranties shall survive the delivery of this Amendment), after giving
effect to this Amendment, as follows:

   (A) The execution and delivery of this Amendment and the revised Notes have
been duly authorized by all requisite corporate action on the part of the
Borrowers and will not violate any provision of law, any order, judgment or
decree of any court or other agency of government, or the articles or bylaws of
any of the parties thereto or any indenture, agreement or other instrument to
which any of the parties thereto is bound, or be in conflict with, or result in
a breach of, or constitute (with due notice or lapse of time or both) a default
under, or result in the creation or imposition of any lien, charge, or
encumbrance of any nature whatsoever upon any

                                      -4-
<PAGE>
 
of the property or assets of any of the parties thereto pursuant to, any such
indenture, agreement or instrument.

   (B) The representations and warranties contained in Section 3 of the Loan
Agreement or in Section 3 of the Security Agreement or in any of the other
Security Documents and the information set forth in the Exhibits thereto (as
previously revised hereunder) and in the Officer's Certificate are true and
correct in all material respects on and as of the date of this Amendment as
though made at and as of such date (except to the extent that such
representations and warranties expressly relate to an earlier date or except to
the extent variations therefrom have been permitted under the terms of the Loan
Agreement or otherwise in writing by the Bank).  No material adverse change has
occurred in the assets, liabilities, financial condition, business or prospects
of the Parent or the other Borrowers, taken as a whole from that disclosed in
the financial statements most recently furnished to the Bank pursuant to
Sections 3.5, 4.1(a) or 4.1(c) of the Loan Agreement.  No Default has occurred
and is continuing.

   (C)  Each of this Amendment and the revised Notes constitutes the legal,
valid and binding obligations of each of the Borrowers, enforceable against each
of the Borrowers in accordance with its terms, subject to bankruptcy,
insolvency, reorganization, moratorium and similar laws affecting the rights and
remedies of creditors generally or the application of principles of equity,
whether in any action at law or proceeding in equity, and subject to the
availability of the remedy of specific performance or of any other equitable
remedy or relief to enforce any right thereunder.

   4.   Waivers.
        ------- 

   The Borrowers have informed the Bank that they changed their fiscal year from
a November 30 fiscal year end to a December 31 fiscal year end, effective as of
December 1, 1994, without the Bank's prior written consent, in violation of
Section 4.6 of the Loan Agreement.  The Borrowers have also informed the Bank
that they failed to maintain a ratio of Indebtedness (excluding trade debt and
accrued liabilities) to Net Cash Flow of no more than 2.00:1.00 for the four-
quarter periods ending on December 31, 1994 and March 31, 1995 in violation of
Section 5.1(e) of the Loan Agreement.  Subject to the terms of this Amendment,
the Bank is willing to waive such Events of Default; provided, however,
                                                     --------  ------- 
nothing in this Amendment (including without limitation this Section 4 or the
interest adjustments set forth in Section 1.4(a) as amended herein) shall
constitute a waiver of any other covenant, Default, Event of Default or right or
remedy now or hereafter available to the Bank and such waivers set forth herein
shall not constitute a waiver of, or consent to, any other fiscal year change or
any breach of the maximum permitted Indebtedness to Net Cash Flow ratio of
2.00:1.00 for any four-quarter period ending after March 31, 1995.

                                      -5-
<PAGE>
 
   5.   Conditions.
        ---------- 

   The willingness of the Bank to agree to the foregoing and to make further
Advances under the Loan Agreement are subject to the following conditions:

   (A) The Borrowers shall have executed and delivered to the Bank (or shall
have caused to be executed and delivered to the Bank by the appropriate persons)
the following:

     (i)  This Amendment, the revised Revolving Note and a Conditional
   Assignment of the Parent's rights under the Distribution Agreement and the
   Escrow Agreement;

     (ii)  True and complete copies of the Distribution Agreement, the Escrow
   Agreement and any required stockholders' and directors' consents and/or
   resolutions, authorizing the execution and delivery of this Amendment and
   other documentation referred to in this Section 4, certified by the
   respective secretaries of the Borrowers; and

     (iii)  Such other supporting documents and certificates as the Bank or its
   counsel may reasonably request.

   (B) The Bank shall have received the favorable written opinion of general
counsel for the Borrowers satisfactory to the Bank in scope and substance.

   (C) The Borrowers shall have paid to the Bank a Commitment increase fee of
$10,000 and a waiver fee of $5,000.

   (D) The proceeds of the $2,000,000 increase in the Commitment provided for
hereunder shall be used solely for the Deposit (as defined in the Distribution
Agreement) and, subject to the terms of the Loan Agreement, shall be deposited
directly into an escrow account at the Escrow Agent pursuant to the Escrow
Agreement.

   (E) All legal matters incident to the transactions contemplated hereby shall
be satisfactory to counsel for the Bank.

   6.   Miscellaneous.
        ------------- 

   (A) As provided in the Loan Agreement, the Borrowers agree to reimburse the
Bank upon demand for all out-of-pocket costs, charges, liabilities, taxes and
expenses of the Bank (including reasonable fees and disbursements of counsel to
the Bank) in connection with the (a) preparation, negotiation, interpretation,
execution and delivery of this Amendment and

                                      -6-
<PAGE>
 
any other agreements, instruments and documents executed pursuant or relating
hereto, and (b) any enforcement hereof.

   (B) This Amendment shall be governed by and construed in accordance with the
laws of the Commonwealth of Massachusetts.

   (C) This Amendment may be executed by the parties hereto in several
counterparts hereof and by the different parties hereto on separate counterparts
hereof, all of which counterparts shall together constitute one and the same
agreement.

                                      -7-
<PAGE>
 
   IN WITNESS WHEREOF, the Bank and the Borrowers have caused this Amendment to
be duly executed as a sealed instrument by their duly authorized
representatives, all as of the day and year first above written.

                                        MEDCHEM PRODUCTS, INC.
                                  
                                  
                                        By:/s/ John J. McDonough
                                           -----------------------------
                                           Title:V.P. Finance C.F.O.
                                  
                                  
                                        MEDCHEM (P.R.), INC.
                                        (f/k/a BioChem Products, Inc.)
                                  
                                  
                                        By:/s/ John J. McDonough
                                           -----------------------------
                                           Title:
                                  
                                  
                                        MEDCHEM SECURITIES CORPORATION
                                  
                                  
                                        By:/s/ John J. McDonough         
                                           -----------------------------
                                           Title:                       
                                  
                                  
                                        MEDCHEM PRODUCTS FOREIGN SALES
                                        CORPORATION
                                  
                                  
                                        By:/s/ John J. McDonough       
                                           -----------------------------
                                           Title:                       
                                  
                                        GESCO INTERNATIONAL, INC.
                                  
                                  
                                        By:/s/ John J. McDonough       
                                           -----------------------------
                                           Title:                       
                                  
                                        FLEET BANK OF MASSACHUSETTS, N.A.
                                  
                                  
                                        By:/s/ Elise M. Russo
                                           -----------------------------
                                           Title:


                                      -8-
<PAGE>
 
                                 Exhibit 1.2(a)
                                 --------------

                                PROMISSORY NOTE
                                ---------------

$9,000,000                                       Dated June 19, 1992
                                                 and amended and restated
Boston, Massachusetts                            on April 14, 1995


        FOR VALUE RECEIVED, the undersigned (the "Makers") hereby jointly and
severally promise to pay to FLEET BANK OF MASSACHUSETTS, N.A. (the "Bank"), or
order, at the principal office of the Bank at 75 State Street, Boston,
Massachusetts  02109 or to such other address as advised in writing by the Bank,
the principal amount of NINE MILLION DOLLARS ($9,000,000) or such lesser amount
as shall equal the aggregate unpaid principal amount outstanding of Revolving
Loans made by the Bank to the Makers pursuant to and as defined in the Agreement
referred to below, in lawful money of the United States of America and in
immediately available funds, and to pay interest on the unpaid principal balance
hereof from time to time outstanding, at said office and in like money and
funds, for the period commencing on June 19, 1992 until paid in full, payable on
the dates and at the rate or rates specified in the Agreement.  All principal
shall be due and payable in accordance with the Agreement, and all principal
remaining unpaid and any accrued but unpaid interest shall in any event be due
and payable on May 31, 1996.

        This Note is issued pursuant to, and entitled to the benefits of, and is
subject to, the provisions of a certain Revolving Credit and Term Loan Agreement
dated as of July 31, 1992 by and among the Makers and the Bank (as amended or
extended from time to time, the "Agreement"), but neither this reference to the
Agreement nor any provision thereof shall affect or impair the absolute and
unconditional obligation of the Makers jointly and severally to pay the
principal of and interest on this Note as herein provided.

        This Note is a revolving note and, subject to the foregoing and to the
terms of the Agreement, the Makers may borrow, pay, prepay and reborrow
hereunder, all in accordance with the provisions of this Note and the Agreement;
provided, however, the principal balance outstanding shall at no time exceed the
--------                                                                        
face amount of this Note.  Under certain circumstances, a portion of the
principal amount is also subject to mandatory prepayment under the terms of the
Agreement.
<PAGE>
 
        In case an Event of Default (as defined in the Agreement) shall occur,
the aggregate unpaid principal of and accrued interest on this Note shall become
or may be declared to be due and payable in the manner and with the effect
provided in the Agreement.

        All agreements involving any of the Makers and the Bank are hereby
expressly limited so that in no contingency or event whatsoever shall the amount
paid or agreed to be paid to the Bank for the use or forbearance of the
indebtedness evidenced hereby exceed the maximum amount which the Bank is
permitted to receive under applicable law. If, from any circumstances
whatsoever, fulfillment of any provision hereof or of the Agreement, at the time
performance of such provision shall be due, shall involve exceeding such amount,
then the obligation to be fulfilled shall automatically be reduced to the limit
of such validity, and if from any circumstance the Bank should ever receive as
interest an amount which would exceed such maximum amount, such amount which
would be excessive interest shall be applied to the reduction of the principal
balance evidenced hereby and not to the payment of interest. As used herein, the
term "applicable law" shall mean the law in effect as of the date hereof;
provided, however, that in the event there is a change in the law which results
--------  -------                                                              
in a higher permissible rate of interest, then this Note shall be governed by
such new law as of its effective date.  This provision shall control every
provision of all agreements involving any of the Makers and the Bank.

        No delay or omission on the part of the Bank in exercising any right
hereunder shall operate as a waiver of such right or of any other right of the
Bank, nor shall any delay, omission or waiver on any one occasion be deemed a
bar to or waiver of the same or any other right on any future occasion.  Each of
the Makers and every endorser or guarantor of this Note, regardless of the time,
order or place of signing, waives presentment, demand, protest, notice of
dishonor and other demands and notices of every kind (except notices, if any,
otherwise expressly provided for in the Agreement) in connection with the
delivery, acceptance, performance and enforcement of this Note and assents to
any extension or postponement of the time of payment or any other indulgence, to
any substitution, exchange or release of collateral, and to the addition or
release of any other party or person primarily or secondarily liable.

        If this Note shall not be paid when due and shall be placed by the Bank
in the hands of any attorney for collection, through legal proceedings or
otherwise, the Makers jointly and severally will pay reasonable attorneys' fees
to the Bank, together with reasonable costs and expenses of collection,
including, without limitation, any such attorneys' fees, costs and expenses
relating to any proceedings with respect to the

                                      -2-
<PAGE>
 
bankruptcy, reorganization, insolvency, readjustment of debt, dissolution or
liquidation of any Maker.

        This Note shall inure to the benefit of the Bank and its successors and
assigns and subsequent holders hereof.

        This Note shall have the effect of an instrument executed under seal and
shall be governed by and construed in accordance with the laws of the
Commonwealth of Massachusetts (without giving effect to any conflicts of laws
provisions contained therein).

                                             MEDCHEM PRODUCTS, INC.
                                     
                                             By:  /s/ John J. McDonough
                                                ------------------------
                                                Title: V.P. Finance C.F.O.
                                     
                                     
                                             MEDCHEM (P.R.), INC.
                                             (f/k/a BioChem Products, Inc.)
                                     
                                             By:  /s/ John J. McDonough
                                                ------------------------
                                                Title:
                                     
                                     
                                             MEDCHEM SECURITIES
                                               CORPORATION
                                     
                                             By:  /s/ John J. McDonough
                                                ------------------------
                                                Title:
                                     
                                     
                                             MEDCHEM PRODUCTS FOREIGN
                                             SALES CORPORATION
                                     
                                             By:  /s/ John J. McDonough
                                                ------------------------
                                                Title:
                                          
                                     
                                             GESCO INTERNATIONAL, INC.
                                     
                                             By:  /s/ John J. McDonough
                                                ------------------------
                                                Title:

<PAGE>
 
                       AMENDMENT TO EMPLOYMENT AGREEMENT
                       ---------------------------------



     This Agreement (the "Agreement"), made as of this ___ day of March, 1995,
is entered into by and between MedChem Products, Inc., a Massachusetts
corporation with its principal place of business at 232 West Cummings Park,
Woburn, Massachusetts 01801 (the "Company"), and Timothy Patrick, residing at
3785 Newport Bay Drive, Alpharetta, Georgia 30202 (the "Employee").

     The Company and the Employee are parties to an Employment Agreement dated
February 13, 1995 (the "Employment Agreement").  The Company and the Employee
desire to make certain amendments to the Employment Agreement.  In consideration
of these premises, the mutual covenants and promises contained herein, and other
good and valuable consideration, the receipt and sufficiency of which are
acknowledged, the parties hereto agree as follows:

     1.  Section 6.3 of the Employment Agreement is hereby amended by replacing
the "." at the very end of such section (after the word "assets") with a semi-
colon, ";", and adding the following after the end of clause (iv) thereof:  "(v)
there is a merger or consolidation of the Company's wholly-owned subsidiary,
Gesco International, Inc. ("Gesco") with any other corporation, other than (A) a
merger or consolidation which would result in the voting securities of Gesco
outstanding immediately prior thereto continuing to represent (either by
remaining outstanding or by being converted into voting securities of the
surviving entity) more than 50% of the combined voting power of the voting
securities of Gesco or such surviving entity outstanding immediately after such
merger or consolidation, (B) a merger or consolidation effected to implement a
recapitalization of Gesco (or similar transaction) in which no "person" (as
hereinabove defined) acquires more than 50% of the combined voting power of
Gesco's then outstanding securities or (C) a merger or consolidation with any
corporation that controls, is controlled by or is under common control with the
Company (including a merger or consolidation with the Company); or (vi) there is
a plan of complete liquidation of Gesco or an agreement for the sale or
disposition by Gesco of all or substantially all of Gesco's assets (such events
in the preceding clauses (v) and (vi) being hereinafter referred to as "Gesco
Events").
<PAGE>
 
     2.  The Employment Agreement is hereby amended by inserting the following
after the end of Section 6.1:

          "(vi) in the event such Change in Control of the Company results from
     a Gesco Event, each option to purchase shares of capital stock of the
     Company previously granted to the Employee pursuant to any stock option
     plan or other employee benefit arrangement of the Company shall continue to
     vest, and shall continue to be exercisable, all in accordance with its
     original terms until its expiration date, notwithstanding any provisions in
     such option relating to earlier termination of such option upon termination
     of employment."

     3.   This Agreement shall be construed, interpreted and enforced in
accordance with the laws of the Commonwealth of Massachusetts, without giving
effect to conflict of laws provisions.

     4.   In all respects other than as specifically provided in this Agreement,
the Employment Agreement is hereby ratified and affirmed.

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the day and year set forth above.

                                          MEDCHEM PRODUCTS, INC.


                                          By:    /s/  James Marten
                                               ----------------------------
                                          Title:        Chairman
                                                ---------------------------


                                             /s/ Timothy Patrick
                                          ---------------------------------
                                          Timothy Patrick

                                     -2- 

<PAGE>
 

                                  EXHIBIT 11
                    MedChem Products, Inc. and Subsidiaries
          Computation of Primary and Fully Diluted Earnings Per Share

<TABLE> 
<CAPTION> 
                                             Three months ended                       Six months ended
                                                   June 30,                                June 30,
                                          1995                1994                1995                1994
                                       -------------------------------         ------------------------------- 
<S>                                    <C>                 <C>                 <C>                <C> 
PRIMARY :                                                                                       
---------                                                                                       
Net income                             $1,174,911            $518,309          $1,980,264          $1,601,445
                                                                                                
Weighted average number of common                                                               
   shares outstanding                  10,252,415          10,091,142          10,242,888          10,091,142
                                                                                                
Dilutive effect of outstanding                                                                  
   stock options                          446,360             213,675             280,042             213,675
                                       -----------       -------------         -----------      -------------- 
Weighted average number of common                                                               
   shares as adjusted                  10,698,775          10,304,817          10,522,930          10,304,817
                                       -----------       -------------         -----------      -------------- 
                                                                                                
Primary earnings per share                  $0.11               $0.05               $0.19               $0.16
                                       ===========       =============         ============     ============== 
FULLY DILUTED:                                                                                  
--------------                                                                                  
Net income                             $1,174,911            $518,309          $1,980,264          $1,601,445
                                                                                                
Weighted average number of common                                                               
   shares outstanding                  10,252,415          10,091,142          10,242,888          10,091,142
                                                                                                
Dilutive effect of outstanding                                                                  
   stock options                          679,271             213,675             398,083             213,675
                                       -----------       -------------         -----------      -------------- 
Weighted average number of common                                                               
   shares as adjusted                  10,931,686          10,304,817          10,640,971          10,304,817
                                       -----------       -------------         -----------      -------------- 
                                                                                                
Fully diluted earnings per share            $0.11               $0.05               $0.19               $0.16
                                       ===========       =============         ===========      ============== 
</TABLE> 


<TABLE> <S> <C>

<PAGE>
 
<ARTICLE> 5
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1995
<PERIOD-START>                             APR-01-1995
<PERIOD-END>                               JUN-30-1995
<CASH>                                           1,335
<SECURITIES>                                         0
<RECEIVABLES>                                    4,429
<ALLOWANCES>                                         0
<INVENTORY>                                      9,347
<CURRENT-ASSETS>                                19,921
<PP&E>                                          13,578
<DEPRECIATION>                                   3,405
<TOTAL-ASSETS>                                  81,031
<CURRENT-LIABILITIES>                            6,356
<BONDS>                                              0
<COMMON>                                           113
                                0
                                          0
<OTHER-SE>                                      56,644
<TOTAL-LIABILITY-AND-EQUITY>                    81,031
<SALES>                                          9,823
<TOTAL-REVENUES>                                 9,823
<CGS>                                            3,163
<TOTAL-COSTS>                                    3,163
<OTHER-EXPENSES>                                 4,537
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 395
<INCOME-PRETAX>                                  1,728
<INCOME-TAX>                                       553
<INCOME-CONTINUING>                              1,175
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                     1,175
<EPS-PRIMARY>                                     0.11
<EPS-DILUTED>                                     0.11
        

</TABLE>


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