PRUDENTIAL SERIES FUND INC
497, 1999-10-01
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                          The Prudential Series Fund, Inc.

                         Supplement dated October 1, 1999
                           Prospectus dated May 1, 1999

    The following disclosure replaces the first paragraph and the following
portfolio headings:
Conservative Balanced Portfolio & Flexible Managed Portfolio; Diversified Bond
Portfolio, Government Income Portfolio and Zero Coupon Bond Portfolios 2000 &
2005; Diversified Conservative Growth Portfolio and High Yield Bond Portfolio,
all in the Section "How the Portfolios are Managed--Portfolios Managers" in
the Prospectus:

    Prudential Investments' Fixed Income Group manages more than $135 billion
for Prudential's retail investors, institutional investors, and policyholders.
Senior Managing Directors James J. Sullivan and Jack W. Gaston head the Group,
which is organized into teams specializing in different market sectors. Top-
down, broad investment decisions are made by the Fixed Income Policy Committee,
whereas bottom-up security selection is made by the sector teams.

    Mr. Sullivan has overall responsibility for overseeing portfolio management
and credit research. Prior to joining Prudential Investments in 1998, he was a
managing director in Prudential's Capital Management Group, where he oversaw
portfolio management and credit research for Prudential's General Account and
subsidiary fixed-income portfolios. He has more than 16 years of experience in
risk management, arbitrage trading, and corporate bond investing.

    Mr. Gaston has overall responsibility for overseeing quantitative research
and risk management. Prior to this appointment in 1999, he was senior managing
director of the Capital Management Group where he was responsible for the
investment performance and risk management for Prudential's General Account
and subsidiary fixed-income portfolios.  He has more than 20 years of
experience in investment management, including extensive experience applying
quantitative techniques to portfolio management.

    The Fixed Income Investment Policy Committee is comprised of key senior
investment managers. Members include seven sector team leaders, the chief
investment strategist, and the head of risk management. The Committee uses a
top-down approach to investment strategy, asset allocation, and general risk
management, identifying sectors in which to invest.

    Conservative Balanced Portfolio, Flexible Managed Portfolio and
                     Diversified Bond Portfolio

    The Corporate Team, headed by Steven Kellner, is primarily responsible for
overseeing the day-to-day management of the Portfolio.  This Team uses a
bottom-up approach, which focuses on individual securities, while staying
within the guidelines of the Investment Policy Committee and the
Portfolio's investment restrictions and policies.  In addition, the Credit
Research team of analysts supports the sector teams using bottom-up
fundamentals, as well as economic and industry trends. Other sector teams may
contribute to securities selection when appropriate.

                              Corporate

Assets Under Management (as of June 30, 1999): $48.6 billion.

Team Leader:  Steven Kellner. General Investment Experience:  13 years.

Portfolio Managers:  8.  Average General Investment Experience:  13 years,
which includes team members with mutual fund experience.


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Sector:  U.S. investment-grade corporate securities.

Investment Strategy:  Focus is on identifying spread, credit quality and
liquidity trends to capitalize on changing opportunities in the market.
Ultimately, they seek the highest expected return with the least risk.

        Government Income Portfolio, Zero Coupon Bond Portfolio 2000 and Zero
                         Coupon Bond Portfolio 2005

    The U.S. Liquidity Team, headed by Michael Lillard, is primarily
responsible for overseeing the day-to-day management of the Portfolio.  This
Team uses a bottom-up approach, which focuses on individual securities, while
staying within the guidelines of the Investment Policy Committee and the
Portfolio's investment restrictions and policies.  In addition, the Credit
Research team of analysts supports the sector teams using bottom-up
fundamentals, as well as economic and industry trends. Other sector teams may
contribute to securities selection when appropriate.

                           U.S. Liquidity

Assets Under Management (as of June 30, 1999):  $27.9 billion.

Team Leader:  Michael Lillard.  General Investment Experience:  12 years.

Portfolio Managers:  10.  Average General Investment Experience:  13 years,
which includes team members with significant mutual fund experience.

Sector:  U.S. Treasuries, agencies and mortgages.

Investment Strategy:  Focus is on high quality, liquidity and controlled risk.

              Diversified Conservative Growth Portfolio and
                     High Yield Bond Portfolio

    The High Yield Team, headed by Casey Walsh, is primarily responsible for
overseeing the day-to-day management of the Portfolio. This Team uses a
bottom-up approach, which focuses on Individual securities, while staying
within the guidelines of the Investment Policy Committee and the Portfolio's
investment restrictions and policies. In addition, the Credit Research team of
analysts supports the sector teams using bottom-up fundamentals, as well as
economic and industry trends. Other sector teams may contribute to securities
selection when appropriate.

                             High Yield

Assets Under Management (as of June 30, 1999):  $9.9 billion.

Team Leader:  Casey Walsh. General Investment Experience:  17 years.

Portfolio Managers:  7.  Average General Investment Experience:  19 years,
which includes team members with significant mutual fund experience.

Sector:  Below-investment-grade corporate securities.

Investment Strategy:  Focus is generally on bonds with high total return
potential, given existing risk parameters. They also seek securities with high
current income, as appropriate.  The Team uses a relative value approach.


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