PRUDENTIAL SERIES FUND INC
497, 2000-09-20
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                       THE PRUDENTIAL SERIES FUND, INC.
                     SUPPLEMENT, DATED SEPTEMBER 7, 2000
                                   TO
                      PROSPECTUS, DATED APRIL 30, 2000


     The  Prudential  Series  Fund's Equity  Portfolio  (the  "Portfolio"),  was
formerly advised by the Prudential Investment  Corporation ("PIC"), a Prudential
subsidiary,   d/b/a  Prudential  Global  Asset  Management  ("PGAM").  Effective
September  7, 2000,  Jennison  Associates  LLC  ("Jennison"),  also a Prudential
subsidiary and a direct,  wholly-owned  subsidiary of PIC, will begin  providing
subadvisory  services  to the  Portfolio.  Effective  August 24,  2000,  Jeffrey
Siegel,  Bradley  Goldberg  and David  Kiefer were named as  co-managers  of the
Portfolio.  Mr. Siegel has been an Executive  Vice  President of Jennison  since
June  1999.  Previously  he was at  TIAA-CREF  from  1988-1999,  where  he  held
positions as a portfolio manager and analyst.  Prior to joining  TIAA-CREF,  Mr.
Siegel was an analyst for Equitable  Capital  Management  and held  positions at
Chase  Manhattan  Bank and First  Fidelity  Bank.  Mr. Siegel earned a B.A. from
Rutgers  University.  Mr.  Goldberg,  an Executive  Vice  President of Jennison,
joined Jennison in 1974 where he also serves as Chairman of the Asset Allocation
Committee. Prior to joining Jennison, he served as Vice President and Group Head
in the Investment  Research Division of Bankers Trust Company.  He earned a B.S.
from the  University  of Illinois and an M.B.A.  from New York  University.  Mr.
Goldberg holds a Chartered  Financial Analyst (C.F.A.)  designation.  Mr. Kiefer
has been a Senior Vice President of Jennison since August 2000.  Previously,  he
was a Managing  Director of PGAM and has been with  Prudential  since 1986.  Mr.
Kiefer  earned a B.S.  from  Princeton  University  and an M.B.A.  from  Harvard
Business School. He holds a Chartered Financial Analyst (C.F.A.) designation.

     The Prudential Series Fund's Equity Income Portfolio (the "Portfolio"), was
formerly advised by the Prudential Investment  Corporation ("PIC"), a Prudential
subsidiary,  d/b/a Prudential  Global Asset Management.  Effective  September 7,
2000, Jennison Associates LLC ("Jennison"),  also a Prudential  subsidiary and a
direct,  wholly-owned  subsidiary  of  PIC,  will  begin  providing  subadvisory
services to the  Portfolio.  The portfolio  managers for the  Portfolio  will be
Thomas  Kolefas  and  Bradley  Goldberg.  Mr.  Kolefas  has been a  Senior  Vice
President  of  Jennison  since  September  2000.  Previously,  he was a Managing
Director and Senior Portfolio Manager of Prudential Global Asset Management.  He
joined  Prudential in May 2000 from Loomis Sayles Co., L.P., where he headed the
Large/Mid  Cap Value Team.  Prior to 1996,  Mr.  Kolefas was  employed by Mackay
Shields  Financial as a portfolio  manager for five years.  Mr. Kolefas earned a
B.S.  and an M.B.A.  from New York  University  and holds a Chartered  Financial
Analyst  (C.F.A.)  designation.  Mr.  Goldberg,  an Executive  Vice President of
Jennison,  joined Jennison in 1974 where he also serves as Chairman of the Asset
Allocation Committee. Prior to joining Jennison, he served as Vice President and
Group Head in the  Investment  Research  Division of Bankers Trust  Company.  He
earned a B.S.  from the  University  of  Illinois  and an  M.B.A.  from New York
University.   Mr.  Goldberg  holds  a  Chartered   Financial   Analyst  (C.F.A.)
designation.

     Jennison is providing  investment  advisory services pursuant to an interim
subadvisory  contract.  Shareholders  will  be  asked  to vote  upon an  ongoing
subadvisory   contract  with  Jennison  at  an  upcoming   special   meeting  of
shareholders.  More  details  on  this  ongoing  subadvisory  contract  will  be
presented in a proxy statement that will be delivered to shareholders.


PSFSUP 6A  Ed. 5/00



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