PHARMOS CORP
S-3, 1997-04-30
PHARMACEUTICAL PREPARATIONS
Previous: PACIFIC HORIZON FUNDS INC, NSAR-B, 1997-04-30
Next: CHAD THERAPEUTICS INC, 8-A12B, 1997-04-30




     As filed with the Securities and Exchange Commission on April 30, 1997

                                                  Registration No. 333-_________
- --------------------------------------------------------------------------------


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                      ------------------------------------



                                    FORM S-3
                             REGISTRATION STATEMENT
                  UNDER THE SECURITIES ACT OF 1933, AS AMENDED

                      ------------------------------------


                               PHARMOS CORPORATION
             (Exact name of registrant as specified in its charter)
                                       
              Nevada                                     36-3207413
   (State or other jurisdiction             (I.R.S. Employer Identification No.)
of incorporation or organization)

                               2 Innovation Drive
                             Alachua, Florida 32615
                                 (904) 462-1210
               (Address, including zip code, and telephone number,
                 including area code, of registrant's principal
                               executive offices)

                      ------------------------------------

                                 GAD RIESENFELD
                               2 Innovation Drive
                             Alachua, Florida 32615
                                 (904) 462-1210
                (Name, address, including zip code, and telephone
               number, including area code, of agent for service)

                      ------------------------------------

                                   Copies to:
                             ADAM D. EILENBERG, ESQ.
                               Eilenberg & Zivian
                          666 Third Avenue, 30th Floor
                            New York, New York 10017

                      ------------------------------------

     Approximate date of commencement of proposed sale to public: As soon as
practicable after the effective date of the registration statement

     If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. | |

     If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered in connection with dividend or interest
reinvestment plans, check the following box. |X|


<PAGE>


                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
                                                           Proposed            Proposed
                                                           Maximum             Maximum              Amount of
Title of Each Class of                Amount to be         Offering Price      Aggregate            Registration
Securities to be Registered           Registered           Per Unit            Price                Fee
- ----------------------------------------------------------------------------------------------------------------
<S>                                  <C>                     <C>              <C>                      <C>   
Shares of Common stock to be         10,000,000(2)           $1.37(4)         $13,700,000              $4,152
sold by Selling Security                                                                         
holders(1)                                                                                       
                                                                                                 
Shares of Common Stock                  159,000(3)           $1.75               $278,250                 $84
issuable upon exercise of                                                                        
Warrants to purchase 159,000                                                                     
Shares at $1.75 per share                                                                        
- -----------------------------------------------------------------------------------------------------------------
Total Registration Fee                                                        $13,978,250              $4,236
</TABLE>
                                                                       
                                                   
(1)  To be offered by selling security holders, after conversion of preferred
     shares, which can be converted in initially two 40% increments and then in
     a 20% increment over a period of 270 days.

(2)  Assumes conversion price for all the preferred stock at $0.60, which is
     estimated for the purpose of determining the maximum number of shares of
     Common Stock obtained upon conversion.

(3)  Pursuant to Rule 416 under the Securities Act of 1933, any additional
     shares of Common Stock issued as a result of the anti-dilution provisions
     of the Warrants pursuant to which the Common Stock will be issued are
     deemed to be registered herewith.

(4)  Estimated solely for the purpose of calculating the registration fee.
     Proposed maximum offering price per share is estimated based upon the
     average of the high and low prices of the Company's Common Stock listed on
     the Nasdaq SmallCap Market on April 25, 1997.

     The registrant hereby amends the registration statement on such date or
dates as may be necessary to delay its effective date until the registrant shall
file a further amendment which specifically states that this registration
statement shall thereafter become effective in accordance with Section 8(a) of
the Securities Act of 1933 or until the registration statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a),
may determine.


<PAGE>



                               PHARMOS CORPORATION

Cross  Reference  Sheet Showing  Location in Prospectus of Information  Required
Therein by

Item 1 through 13 of Form S-3

<TABLE>
<CAPTION>
      Registration Statement                                            Prospectus Caption
          Item and Heading                                                  of Location
          ----------------                                                  -----------
<S>   <C>                                                              <C>
  1.  Forepart of the Registration
      Statement and Outside Front
      Cover Page of Prospectus ........................................Outside Front Cover

  2.  Inside Front and Outside Back
      Cover Pages and Prospectus.......................................Inside Front Cover Page

  3.  Summary Information,
      Prospectus Summary
      and Ratio of Earnings to                                         Outside Front Cover,
      Fixed Charges....................................................Risk Factors

  4.  Use of Proceeds..................................................Use of Proceeds

  5.  Determination of Offering Price..................................Cover Page

  6.  Dilution.........................................................Dilution

  7.  Selling Security Holders.........................................Selling Security Holders

  8.  Plan of Distribution.............................................Cover Page, Plan of Distribution

  9.  Description of the Securities to
      be Registered....................................................Description of Securities

 10.  Interest of Named Experts and Counsel............................Experts

 11.  Material Changes.................................................Recent Developments

 12.  Incorporation of Certain
      Information by Reference.........................................Incorporation of Certain
                                                                       Documents by Reference

 13.  Disclosure of Commission Position
      on Indemnification for Securities
      Act Liabilities..................................................Commission's Policy on
                                                                       Indemnification for Securities Act
                                                                       Liabilities
</TABLE>


<PAGE>



                               PHARMOS CORPORATION
                               -------------------


                       10,000,000 SHARES OF COMMON STOCK,
                          $.03 PAR VALUE, TO BE SOLD BY
                            SELLING SECURITY HOLDERS

                     159,000 SHARES OF COMMON STOCK ISSUABLE
                  UPON EXERCISE OF WARRANTS TO PURCHASE SHARES
                     AT AN EXERCISE PRICE OF $1.75 PER SHARE

     This Prospectus covers the proposed offer and resale of up to 10,000,000
shares (the "Shares"), the amount of which is calculated based on a $0.60
conversion price, of common stock, par value $.03 ("Common Stock") of Pharmos
Corporation (the "Company") held by stockholders (the "Selling Stockholders")
who purchased 6,000 shares ($6,000,000 principal amount) of 5% Preferred Stock
(the "Series B Preferred Stock") convertible into such shares in a private
placement transaction in March 1997 (the "Private Placement Transaction"). The
Private Placement Transaction, in which the Company issued 6,000 shares of
Series B Preferred Stock to the Selling Stockholders for the principal amount of
$6,000,000, was completed on March 31, 1997 (the "Closing Date"). The preferred
shares can be converted by the Selling Stockholders as follows: up to 40% of
their initial investment after 90 days from the Closing Date, up to a cumulative
of 80% of their initial investment after 180 days from the Closing Date, and up
to a cumulative of 100% of their initial investment after 270 days from the
Closing Date, at between 80% to 83% of prevailing market prices at time of
conversion.

     This Prospectus also covers the offer and proposed sale by the Company of
up to (i) 159,000 shares of Common Stock issuable upon the exercise by the
holders thereof of warrants to purchase 159,000 shares (which amount may
increase solely to account for applicable anti-dilution adjustments, if any) at
an exercise price of $1.75 per share issued to the Selling Stockholders in
connection with the Private Placement Transaction. (All of the warrants set
forth above are hereinafter separately and collectively referred to as the
"Warrants" and the shares of Common Stock issuable upon the exercise of the
Warrants are hereinafter separately and collectively referred to as the "Warrant
Shares.")

     In connection with this offering, the Selling Stockholders and certain
holders of the Warrants who may be deemed to be "affiliates" of the Company, as
that term is defined under the Securities Act of 1933, as amended (the "Act"),
may be deemed to be an "underwriter," as that term is defined under the Act, of
the Shares or Warrant Shares offered hereby. It is anticipated that the Selling
Stockholders and such affiliates intend to sell the Shares or Warrant Shares
offered hereby from time to time for their own respective accounts in the open
market at the prices prevailing therein or in individually negotiated
transactions at such prices as may be agreed upon. Each Selling Stockholder and
such affiliate will bear all expenses with respect to the offering of the Shares
or Warrant Shares offered hereby by him except the costs of legal counsel and
costs associated with registering such shares under the Act and preparing and
printing this Prospectus.

     The net proceeds from Shares to be sold by the Selling Stockholders (and by
holders of Warrant Shares who exercise their Warrants) will inure entirely to
their benefit and not to


<PAGE>



that of the Company; however the Company will receive proceeds from the exercise
of the Warrants.

     The Company's Common Stock is traded on the over-the-counter market and is
quoted on the Nasdaq SmallCap Market under the symbol "PARS" The closing price
of the Company's Common Stock on April 25, 1997 was $1.41.



<PAGE>


THESE SECURITIES INVOLVE A HIGH DEGREE OF RISK AND SUBSTANTIAL DILUTION AS
DESCRIBED HEREIN (SEE "RISK FACTORS" AND "DILUTION").

THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE SECURITIES
AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.


            The date of this Prospectus is _________________________


<PAGE>

     The laws of many states provide exemptions from registration,  particularly
for sales of securities  by persons  other than issuers,  such as certain of the
Selling  Stockholders  and  holders of the  Warrants,  who do not have a control
relationship  with the issuer,  and for the subsequent resale of such securities
by purchasers  thereof.  Purchasers  hereunder  should consult with their broker
and/or attorney to determine whether applicable state laws permit such purchases
and resales by them.

     With  respect  to the  proposed  sale of the Shares  offered  hereby by the
Selling  Stockholders  and the sale of the Warrant  Shares by the  Company  upon
exercise  of the  Warrants,  the  Company  is  taking  steps to  register  these
securities or permit such sales  pursuant to exemption  from  registration  only
under the laws of California, Connecticut, Florida, Massachusetts, Michigan, New
Jersey, New York,  Pennsylvania and Texas.  Holders of Shares,  therefore,  must
sell their Shares  (through a  broker/dealer  or  otherwise),  either:  (i) to a
resident  of  one  of the  aforementioned  states  or to an  entity,  such  as a
broker/dealer  registered  in such state,  which may be exempt under  applicable
state laws, or (ii) pursuant to another applicable exemption. In such event, the
Company  will only  permit  the  transfer  of the Shares if its  transfer  agent
receives a certification from the holder that the sale was made to a resident of
one of the aforementioned  states or to a state registered  broker/dealer or the
Company receives an opinion of counsel, reasonably satisfactory to the Company's
counsel,  that the resale of the Shares is  otherwise  exempt from  registration
under applicable state law.

     With respect to the proposed sale of the Warrant Shares,  if holders of the
Warrants are not residents of the aforementioned states, the Company will not be
able to permit  them to exercise  Warrants  held by them,  unless  such  holders
obtain an opinion of counsel,  satisfactory to the Company's counsel,  that such
transaction is exempt from registration.  Under such  circumstances,  their only
alternatives  may be to sell their Warrants and/or Common Stock to a resident of
the aforementioned  states or to sell their Warrants and/or Warrant Shares to an
entity,  such as a registered  broker-dealer in such state,  which may be exempt
under applicable state laws.

     Holders of the Warrants  and/or  Warrant  Shares should  consult with their
broker and/or  attorney to determine what actions should be taken to comply with
the laws of their state with respect to any Warrants  and/or Warrant Shares held
by them and, specifically with respect to the Warrants,  ensure that such action
is taken well  prior to the  respective  expiration  dates of the  Warrants,  if
necessary.

     The  Company  will  furnish  to each  person  to whom  this  Prospectus  is
delivered,  upon written request, a copy of any or all of the documents referred
to by reference,  other than exhibits to such documents unless such exhibits are
specifically incorporated herein by reference.  Requests should be addressed to:
Mr. Gad Riesenfeld,  President and Chief Operating Officer, Pharmos Corporation,
2 Innovation Drive, Alachua, Florida 32615, (904) 462-1210.


<PAGE>


     NO  DEALER,  SALESMAN  OR  OTHER  PERSON  HAS BEEN  AUTHORIZED  TO GIVE ANY
INFORMATION  OR TO MAKE ANY  REPRESENTATION  OTHER THAN THOSE  CONTAINED IN THIS
PROSPECTUS.  ANY INFORMATION OR REPRESENTATION NOT HEREIN CONTAINED, IF GIVEN OR
MADE,  MUST NOT BE RELIED UPON AS HAVING BEEN  AUTHORIZED  BY THE COMPANY.  THIS
PROSPECTUS  DOES NOT  CONSTITUTE  AN OFFER OR  SOLICITATION  IN  RESPECT  OF THE
SECURITIES  IN ANY  JURISDICTION  IN WHICH SUCH OFFER OR  SOLICITATION  WOULD BE
UNLAWFUL. DELIVERY OF THIS PROSPECTUS SHALL NOT, UNDER ANY CIRCUMSTANCES, CREATE
ANY  IMPLICATION  THAT THERE HAS BEEN NO CHANGE IN THE  AFFAIRS  OF THE  COMPANY
SINCE THE DATE OF THIS PROSPECTUS.


<PAGE>



                             ADDITIONAL INFORMATION

     The Company has filed with the  Securities  and  Exchange  Commission,  450
Fifth Street, Washington, D.C. 20549, a Registration Statement on Form S-3 under
the Securities Act of 1933 with respect to the securities  offered hereby.  This
Prospectus filed as part of such Registration Statement does not contain all the
information set forth in, or annexed as exhibits to, the Registration Statement.
For further  information  pertaining to the  securities  offered  hereby and the
Company,  reference  is  made to the  Registration  Statement  and the  exhibits
thereto. The Registration Statement and exhibits thereto may be inspected at the
Headquarters  Office of the  Securities and Exchange  Commission  located at 450
Fifth Street,  N.W.,  Room 1024,  Washington,  D.C.  20549 and at certain of the
Commission's regional offices at the following addresses:  7 World Trade Center,
Suite 1300, New York, New York 10048;  Northwest Atrium Center, 500 West Madison
Street,  Suite 1400,  Chicago,  IL 60661.  Copies of this  material  also may be
obtained  from the Public  Reference  Section of the SEC,  at 450 Fifth  Street,
N.W., Room 1024, Washington,  D.C. at prescribed rates.  Electronic registration
statements made through the Electronic  Data  Gathering,  Analysis and Retrieval
System are publicly  available  through the Commission's  World Wide Web site at
http:\www.sec.gov.  The statements  contained in this Prospectus  concerning the
contents of any contract or document  referred to are not necessarily  complete,
and in each instance, reference is made to such contract or document filed as an
exhibit to the  Registration  Statement,  each statement  being qualified in all
respects by provisions  of such exhibit to which  reference is hereby made for a
full statement of the provisions thereof.




<PAGE>



                                   THE COMPANY

     The Company is engaged in the development of novel pharmaceuticals based on
innovative drug design technologies  targeting diseases of the eye,  principally
ocular inflammation, and the brain, principally stroke and head trauma.

     Its   leading   product,   Lotemax(TM),   is   a   proprietary   ophthalmic
anti-inflammatory  drug designed with the  Company's  proprietary  "site active"
concept  system  and  has  demonstrated  significant  efficacy  in a  series  of
completed  Phase III  clinical  trials and a uniquely  superior  safety  profile
compared to currently available ophthalmic  steroids.  The Company has submitted
its New Drug  Application  ("NDA")  for  Lotemax(TM)  to the U.S.  Food and Drug
Administration ("FDA").

     The  Company's  principal  executive  offices are  located at 2  Innovation
Drive, Alachua, Florida 32615, telephone (904) 462-1210.


                                  RISK FACTORS

     The Common  Stock  being  offered  hereby  involves a high  degree of risk.
Prospective  investors should  carefully  consider the following risk factors in
addition to other  information  contained in this  Prospectus,  in evaluating an
investment in the shares of Common Stock offered hereby.

Early Stage of Development; Technological Uncertainty

     The Company is at an early stage of  development.  Apart from  Lotemax(TM),
most of the  Company's  other  potential  products are early in the research and
development phase, and product revenues may not be realized from the sale of any
such  products  for at least  the next  several  years,  if at all.  Many of the
Company's  proposed products will require  significant  additional  research and
development efforts prior to any commercial use, including extensive preclinical
and clinical  testing as well as lengthy  regulatory  approval.  There can be no
assurance  that  the  Company's   research  and  development   efforts  will  be
successful,  that the  Company's  potential  products  will prove to be safe and
effective in clinical trials or that any commercially  successful  products will
ultimately be developed by the Company.

History of Operating Losses; Accumulated Deficit

     The  Company  has  experienced   significant  operating  losses  since  its
inception.  As of December 31, 1996, the Company had an  accumulated  deficit of
approximately $62 million. The Company expects to incur operating losses over at
least the next several years as the Company's  research and development  efforts
and preclinical and clinical testing activities continue.  The Company's ability
to achieve profitability depends in part upon its ability, alone or with others,
to  successfully  commercialize  and  receive  approval  on its  first  proposed
product,  to complete  development  of its other  proposed  products,  to obtain
required regulatory approvals and to manufacture and market such products.


                                        1


<PAGE>


Future Capital Needs; Uncertainty of Additional Financing

         The Company's  operations to date have consumed  substantial amounts of
cash. The  development of the Company's  technology and potential  products will
require  a  commitment   of   substantial   funds  to  conduct  the  costly  and
time-consuming  research necessary to develop and optimize such technology,  and
ultimately, to establish manufacturing and marketing capabilities. The Company's
future capital  requirements  will depend on many factors,  including  continued
scientific progress in the research and development of the Company's  technology
and drug  programs,  the  ability  of the  Company  to  establish  and  maintain
collaborative  arrangements  with  others for drug  development,  progress  with
preclinical  and  clinical  trials,  the time and costs  involved  in  obtaining
regulatory  approvals,  the costs  involved in preparing,  filing,  prosecuting,
maintaining  and enforcing  patent claims,  competing  technological  and market
developments,  changes in its  existing  research  relationships  and  effective
product commercialization activities and arrangements.

     The Company  believes that its current cash  resources and interest  income
thereon,  including  approximately $5.8 million in net cash and cash equivalents
received  by the  Company  from the  Private  Placement  Transaction,  should be
sufficient to fund its operating expenses and capital  requirements as currently
planned  through the first  quarter of 1998.  The Company  will seek  additional
funding through  collaborative  arrangements or through future public or private
equity or debt financing.  There can be no assurance that  additional  financing
will be available on acceptable  terms, or at all. In addition,  pursuant to the
Private  Placement  Transaction,  the Selling  Stockholders  are granted limited
rights to approve of the Company's efforts to obtain  convertible debt or equity
for a period of one hundred  eighty (180) days  following  the Closing  Date. If
additional  funds are raised by issuing equity  securities,  further dilution to
stockholders may result. If adequate funds are not available, the Company may be
required to delay,  reduce the scope of or eliminate one or more of its research
or  development   programs  or  to  obtain  funds  through   arrangements   with
collaborative  partners or others  that may  require  the Company to  relinquish
rights to certain of its technologies,  product  candidates or products that the
Company would otherwise seek to develop or commercialize itself.

Dependence on Potential Collaborative Partners

     The   Company's   strategy   for   the   development,   clinical   testing,
manufacturing,  marketing  and  commercialization  of  certain  of its  products
includes  entering  into  various   collaborations   with  corporate   partners,
licensors,  licensees  and  others.  To  date,  the  Company  has  entered  into
agreements  with  Bausch & Lomb to  manufacture  and market the  Company's  lead
product,  Lotemax(TM),  in the United States and throughout  Europe,  Canada and
selected  other  countries.  The  agreements  also cover the  co-development  of
Lotemax(TM)  line extension  products  currently being developed by the Company.
There can be no assurance  that the Company will be able to negotiate any future
collaborative  agreement  with Bausch & Lomb or other  companies  on  acceptable
terms,  or  that  any  present  or  future  collaborative   agreements  will  be
successful.  To the extent  that the  Company  chooses  not to or is not able to
establish such  arrangements,  the Company would  experience  increased  capital
requirements to undertake such activities at its own expense.  In addition,  the
Company may encounter  significant  delays in introducing its proposed  products
currently under development into certain markets or find that the development,


                                        2


<PAGE>


manufacture,  or sale of its  proposed  products  in such  markets is  adversely
affected by the absence of such collaborative agreements.

Technological Change and Competition

     The  pharmaceutical  industry  is  subject  to  rapid,   unpredictable  and
significant  technological  change.  Competition  from  universities,   research
institutions and other pharmaceutical,  chemical and biotechnology  companies is
intense.  Many  competitors  or potential  competitors  have  greater  financial
resources,   research  and  development  capabilities,   and  manufacturing  and
marketing experience than the Company. To this end, the Company has entered into
agreements  with Bausch & Lomb for the manufacture and marketing of Lotemax(TM).
There can be no assurance  that  developments  by the Company's  competitors  or
potential  competitors  will not render the  Company's  technology  or  proposed
applications of its technology obsolete.

Technologies Subject to Licenses

     As a licensee  of certain  research  technologies,  the Company has various
license  agreements with certain U.S.  federal agencies and the State of Israel,
certain  universities  and Dr.  Nicholas  Bodor,  a former  vice  president  and
director  of the  Company,  wherein  the  Company  has  acquired  exclusive  and
coexclusive rights to develop and commercialize  certain research  technologies.
The  agreements  generally  require  the  Company  to pay  royalties  on sale of
products  developed  from the licensed  technologies  and fees on revenues  from
sublicensees,  where applicable, and the Company is responsible for the costs of
filing and prosecuting patent applications.  In addition,  some of the Company's
license  agreements  require that the Company  commit  certain sums annually for
research  and  development  of the  licensed  products.  The  Company's  license
agreements with the University of Florida and with Dr. Bodor require the Company
to pay annual license  maintenance fees as well as make payments upon completion
of certain  milestones  occurring  in the  clinical  trials of certain  licensed
products.

     The exclusivity of license agreements generally expires fifteen years after
the  later  of  commercialization  or the  effectiveness  of the  patents.  Each
agreement  is  terminable  by either  party,  upon  notice,  if the other  party
defaults in its obligations.

Uncertainty of Protection of Patents and Proprietary Rights

     The  Company's  success  will depend in large part on its ability to obtain
patents,   maintain  trade  secrets  and  operate  without   infringing  on  the
proprietary  rights of  others,  both in the U.S.  and in other  countries.  The
patent positions of pharmaceutical companies can be highly uncertain and involve
complex   legal  and  factual   questions,   and   therefore   the  breadth  and
enforceability of claims allowed in pharmaceutical  patents cannot be predicted.
There  can be no  assurance  that any  issued  or  pending  patents  will not be
challenged,  invalidated or circumvented,  or that the rights granted thereunder
will provide proprietary protection or competitive advantages to the Company.


                                        3


<PAGE>


     The commercial success of the Company also will depend, in part, on Pharmos
not  infringing  patents  issued  to others  and not  breaching  the  technology
licenses upon which any Company products are based. It is uncertain  whether any
third-party patents will require the Company to alter its products or processes,
obtain licenses or cease certain activities.  In addition, if patents are issued
to others which contain  competitive or conflicting  claims, and such claims are
ultimately  determined  to be  valid,  the  Company  may be  required  to obtain
licenses to these patents or to develop or obtain alternative technology. If any
licenses are required,  there can be no assurance  that the Company will be able
to obtain any such  licenses on  commercially  favorable  terms,  if at all. The
Company's  breach of an  existing  license or failure to obtain a license to any
technology that it may require to commercialize its products may have a material
adverse  impact on the Company.  Litigation,  which could result in  substantial
costs to the Company,  may also be necessary to enforce any patents  licensed or
issued to the Company or to  determine  the scope and  validity  of  third-party
proprietary  rights.  If  competitors  of the  Company  prepare  and file patent
applications in the U.S. that claim technology also claimed by the Company,  the
Company may have to participate in interference proceedings declared by the U.S.
Patent and  Trademark  Office to determine  priority of  invention,  which could
result in  substantial  costs to the Company,  even if the  eventual  outcome is
favorable  to the  Company.  An adverse  outcome  could  subject  the Company to
significant liabilities to third parties, require disputed rights to be licensed
from third parties or require the Company to cease using such technology.

     The Company  also relies on secrecy to protect its  technology,  especially
where patent  protection is not believed to be appropriate or obtainable.  Thus,
Pharmos  protects  its  proprietary  technology  and  processes,   in  part,  by
confidentiality   agreements   with  its  employees,   consultants  and  certain
contractors.  There  can be no  assurance  that  these  agreements  will  not be
breached,  that the Company would have adequate remedies for any breach, or that
the Company's trade secrets will not otherwise  become known or be independently
discovered by competitors.

Legal Proceedings and Disputes

     There are  currently  no  material  legal  proceedings  pending  against or
involving the Company.

Extensive Government Regulation

     The Company's  products  require the approval of the FDA before they can be
marketed  in the U.S.  In  addition,  approvals  are also  required  from health
authorities  in most  foreign  countries  before the  Company's  products can be
marketed in such  countries.  Before an NDA, a type of submission used to obtain
FDA  approval  to market a new drug,  can be filed with the FDA, a product  must
undergo, among other things, extensive animal testing and human clinical trials,
which  can take up to seven  years to  complete.  Except  for  Lotemax(TM),  the
Company has not yet filed NDAs on its products. The time required for regulatory
approval of the Company's  products after  acceptance for filing an NDA can vary
and is usually  one to three years or more,  and the FDA may require  additional
animal studies and/or clinical trials before granting approval.  There can be no
assurance  that the FDA and foreign  regulatory  agencies will be satisfied with
the  information,  including that emanating from clinical  trials,  submitted to
them

                                        4

<PAGE>



in applications  (like NDAs) seeking  approval and will approve the marketing of
any of the Company's  potential  products,  or that problems will not arise that
could delay or prevent the commercialization of the Company's future products.

     There can be no  assurance  that any  potential  products  developed by the
Company  alone or in  conjunction  with  others  will be  proven  to be safe and
effective  in  clinical  trials and will meet all of the  applicable  regulatory
requirements   needed  to  receive  marketing   approval.   Data  obtained  from
preclinical   testing  and  clinical   trials  can  be  susceptible  to  varying
interpretations  which could delay,  limit or prevent regulatory  approvals.  In
addition,  delays or  disapprovals  may be  encountered  based  upon  additional
government regulation resulting from future legislation or administrative action
or changes in FDA policy made during the period of product  development  and FDA
regulatory review.  Similar delays may also be encountered in foreign countries.
There can be no assurance that even after such time and expenditures, regulatory
approval will be obtained for any potential  products  developed by the Company.
If regulatory approval of a product is granted, such approval will be limited to
those  therapeutic  uses for which the  product  has been  demonstrated  through
clinical studies and other means to be safe and effective. Furthermore, approval
may entail ongoing requirements for post-marketing  studies.  Even if regulatory
approval is obtained, a marketed product, its manufacturer and its manufacturing
facilities  are  subject to  continual  review  and  periodic  inspections.  The
regulatory  standards for manufacturing are currently being applied  stringently
by  the  FDA.   Discovery  of  previously   unknown  problems  with  a  product,
manufacturer  or facility  may result in FDA  restrictions  being placed on such
product or manufacturer  or facility,  including an order to withdraw a specific
product from the market, and may also result in court enforced sanctions against
the product, manufacturer or facility.

     The Company may establish  collaborative  relationships to conduct clinical
testing and seek  regulatory  approvals to market its products in major  markets
outside the U.S.  There can be no assurance  that the Company will be successful
in establishing such  relationships or that such approvals will be received in a
timely  manner,  if at all. To market its products  abroad,  the Company is also
subject to numerous and varying foreign regulatory requirements,  implemented by
foreign health  authorities,  governing the design and conduct of human clinical
trials, pricing and marketing. The approval procedure varies among countries and
can involve  additional  testing,  and the time required to obtain  approval may
differ from that required to obtain FDA approval. At present,  foreign marketing
authorizations are applied for at a national level, although within the European
Union ("EU") certain registration  procedures are available to companies wishing
to  market  a  product  in more  than one EU  member  country.  If a  regulatory
authority is satisfied  that adequate  evidence of safety,  quality and efficacy
has been  presented,  marketing  authorization  is almost  always  granted.  The
foreign  regulatory  approval  process includes all of the risks associated with
obtaining  FDA  approval  set forth  above.  Approval by the FDA does not ensure
approval by other countries.

Lack of Sales and Marketing Capability

     The Company has no  experience  in sales,  marketing  or  distribution.  To
market any of its products directly,  the Company must develop a marketing force
and sales  force  with  technical  expertise  and with  supporting  distribution
capability. Alternatively, the Company may obtain

                                        5

<PAGE>



the  assistance of a  pharmaceutical  company with an  established  distribution
system and sales force.  The Company has entered into  agreements  with Bausch &
Lomb to market Lotemax(TM). There can be no assurance, however, that the Company
will be able to establish sales and  distribution  capabilities or be successful
in gaining market acceptance for its products.

Lack of Manufacturing Capability

     The Company  currently  has limited  manufacturing  capacity to produce its
products  for  clinical  trials.  The  Company's  agreements  with Bausch & Lomb
address  the   manufacturing  of  Lotemax(TM).   The  proposed   products  under
development by the Company have never been  manufactured  on a commercial  scale
and there can be no assurances  that such products can be manufactured at a cost
or in  quantities  necessary  to make  them  commercially  viable.  Any delay in
availability  of products may result in delay in the  submission of products for
regulatory  approval or the market  introduction  and  subsequent  sales of such
products, which would have a material adverse effect on the Company.

Need to Attract and Retain Key Employees and Consultants

     The Company is highly dependent on the principal  members of its scientific
and  management  staff.  In  addition,  the Company  relies on  consultants  and
advisors to assist the  Company in  formulating  its  research  and  development
strategy. Retaining and attracting qualified personnel, consultants and advisors
will be  critical  to the  Company's  success.  In order to pursue  its  product
development and marketing plans, the Company will be required to hire additional
qualified scientific  personnel to perform research and development,  as well as
personnel   with   expertise  in  clinical   testing,   government   regulation,
manufacturing  and  marketing.  The  Company  faces  competition  for  qualified
individuals   from  numerous   pharmaceutical   and   biotechnology   companies,
universities and other research institutions. There can be no assurance that the
Company will be able to attract and retain such  individuals on acceptable terms
or at all.

     The Company's  clinical  development  is conducted  under  agreements  with
universities and medical  institutions.  The Company depends on the availability
of a principal investigator for each such program, and the Company cannot assure
that these  individuals  or their  research  staffs will be available to conduct
clinical development.  The Company's academic collaborators are not employees of
the Company.  As a result, the Company has limited control over their activities
and can expect  that only  limited  amounts of their time will be  dedicated  to
Company activities.  The Company's academic collaborators may have relationships
with other commercial entities, some of which compete with the Company.

Uncertainty of Health Care Reform Measures and Third-Party Reimbursement

     The  levels  of   revenues   and   profitability   of   biotechnology   and
pharmaceutical   companies  may  be  affected  by  the  continuing   efforts  of
governmental  and  third-party  payors to  contain or reduce the costs of health
care through various means. For example, in certain foreign markets,  pricing or
profitability of prescription  pharmaceuticals is subject to government control.
In the U.S.,  there have been, and the Company  expects that there will continue
to be, a number of federal  and state  proposals  to control  health care costs.
While the Company cannot predict

                                        6

<PAGE>



whether any such  legislative  or  regulatory  proposals  will be adopted or the
effect such proposals may have on its business, the uncertainty surrounding such
proposals could have a material adverse effect on the Company.  Furthermore, the
Company's  ability to  commercialize  its  potential  product  portfolio  may be
adversely  affected to the extent that such  proposals  have a material  adverse
effect on the business, financial condition and profitability of other companies
that  are  prospective  collaborators  for  certain  of the  Company's  proposed
products.

Dependence on Reimbursement

     Pharmos' ability to commercialize  its products  successfully may depend in
part on the  extent to which  reimbursement  for the cost of such  products  and
related  treatments  will be available  from  government  health  administration
authorities, private health insurers and other organizations. Third-party payors
are  increasingly  challenging  the  price of  medical  products  and  services.
Significant  uncertainty exists as to the reimbursement status of newly approved
health care products,  and there can be no assurance  that adequate  third-party
coverage will be available to enable Pharmos to maintain price levels sufficient
to realize an appropriate return on its investment in product development.

Risk of Product Liability; Availability of Insurance

     The design,  development and manufacture of the Company's  products involve
an inherent risk of product liability claims and associated  adverse  publicity.
Although the Company currently maintains general liability insurance,  there can
be no assurance  that the coverage  limits of the Company's  insurance  policies
will be adequate.  Similarly,  the Company  currently  maintains  clinical trial
liability  insurance,  but there can be no assurance  that the coverage limit of
the Company's insurance policies will be adequate.  The Company currently has no
product liability insurance, and there can be no assurance that the Company will
be able to obtain or maintain product liability insurance on acceptable terms or
with  adequate  coverage  against  potential  liabilities.   Such  insurance  is
expensive,  difficult  to  obtain  and may not be  available  in the  future  on
acceptable  terms or at all. A successful  claim brought  against the Company in
excess of the Company's  insurance coverage could have a material adverse effect
upon the Company and its financial condition.

Use of Hazardous  Materials;  Potential  Liability to Comply with  Environmental
Laws

     The  Company's  research and  development  involves the  controlled  use of
hazardous  materials.  Although the Company believes that its safety  procedures
for handling and  disposing of such  materials  comply in all material  respects
with the  standard  prescribed  by state and  federal  regulations,  the risk of
accidental  contamination  or injury from these  materials  cannot be completely
eliminated.  In the event of such an accident,  the Company could be held liable
for any damages that result,  and any such liability  could exceed the resources
of the  Company.  The  Company  may  incur  substantial  costs  to  comply  with
environmental regulations if the Company develops manufacturing capacity.


                                        7

<PAGE>



Market for the Company's  Securities;  Shares Eligible for Future Sale; Possible
Volatility of Share Prices

     The market price of the Company's Common Stock, like that of other emerging
pharmaceutical  companies,  has fluctuated  significantly in recent years and is
likely to  fluctuate  in the  future.  Announcements  by the  Company  or others
regarding  scientific  discoveries,   technological   innovations,   litigation,
products,  patents or  proprietary  rights,  the  progress of  clinical  trials,
government  regulation,  public  concern  as to the  safety  of  drugs  and  the
reliability of the Company's testing processes and general market conditions may
have a significant  impact on the market price of the Common Stock. The addition
of the shares being offered hereby and the shares  issuable upon exercise of the
Company's  currently   outstanding   warrants  and  options  to  the  number  of
publicly-traded  shares of the Company's  Common Stock may affect the volatility
of share prices of the Company's Common Stock.

Outstanding Stock Options and Warrants

     As of December 31, 1996 the Company had outstanding incentive stock options
to  purchase  an  aggregate  of  513,253  shares of Common  Stock at an  average
exercise price of $2.13 per share and non-qualified stock options to purchase an
aggregate of 432,182 at an average  exercise  price of $3.12 per share issued to
employees,  directors  and  consultants  pursuant  to  stock  option  plans  and
individual  agreements with management and directors of the Company and warrants
to purchase  3,138,789  shares of the Company's Common Stock at an average price
of $2.13 per share.

     The Company may issue additional capital stock,  warrants and/or options to
raise capital in the future.  The Company  regularly  examines  opportunities to
expand its  technology  base and product  line  through  means such as licenses,
joint  ventures and  acquisition  of assets or ongoing  businesses and may issue
securities in connection  with such  transactions.  However,  no  commitments to
enter  into or pursue  any such  transaction  have been made and there can be no
assurance that any such discussions  will result in any such  transaction  being
concluded.  In order to attract and retain key  personnel,  the Company may also
issue  additional  securities,  including stock options,  in connection with its
employee  benefit  plans.  During the terms of such  options and  warrants,  the
holders  thereof are given the  opportunity  to profit from a rise in the market
price of the Company's  Common Stock.  The exercise of such options and warrants
may have an adverse  effect on the market value of the  Company's  Common Stock.
Also, the existence of such options and warrants may adversely  affect the terms
on which the Company can obtain additional equity financing.

Convertible  Securities;  Potential  Dilution and Adverse  Impact on  Additional
Financing

     As of December 31, 1996, the Company had  outstanding  options and warrants
to purchase an  aggregate  of 4,084,224  shares of Common  Stock,  at a weighted
average  exercise  price of  $2.2347591  per share.  The Company is obligated to
issue up to 7,400,000  shares of Common Stock upon conversion of 1,400 shares of
the Series A Preferred  Stock and 6,000  shares of the Series B Preferred  Stock
(collectively,  the "Preferred Stock") outstanding as of April 4, 1997, based on
a conversion price of $1.00, which is derived from 80% of the closing

                                        8

<PAGE>



price of the  Common  Stock as of April 4, 1997.  The exact  number of shares of
Common  Stock  issuable  upon  conversion  cannot be  estimated  with  certainty
because,  generally, such issuances of Common Stock will vary inversely with the
market price of the Common Stock at the time of such conversion, and there is no
limit on the number of shares of Common Stock that may be  issuable.  The number
of shares of Common Stock  issuable upon  conversion  of the Preferred  Stock is
also subject to various  adjustments  to prevent  dilution  resulting from stock
splits,  stock dividends or similar  transactions.  Further, the Company may, at
its election,  choose to issue additional shares of Common Stock in lieu of cash
dividends due to the holders of the Preferred Stock.

     To the extent  shares of Common Stock are issued in lieu of cash  dividends
or due to  conversions  of the  Preferred  Stock,  substantial  dilution  of the
interests of the Company's stockholders is likely to result and the market price
of the Common Stock may be materially adversely affected.  Such dilution will be
greater if the future market price of the Common Stock  decreases.  For the life
of the Preferred  Stock,  the holders will have the opportunity to profit from a
rise in the price of the underlying  securities.  The existence of the Preferred
Stock is  likely  to  affect  materially  and  adversely  the terms on which the
Company can obtain additional financing,  and the holders of the Preferred Stock
can be  expected  to convert  shares of the  Preferred  Stock at a time when the
Company would otherwise, in all likelihood, be able to obtain additional capital
by an offering of its  unissued  capital  stock on terms more  favorable  to the
Company then those provided by the Preferred Stock.

     The Company has registered the Common Stock issuable upon conversion of the
Preferred Stock, certain of which are being offered pursuant to this Prospectus.
Shares of Common Stock issuable upon  conversion of the Series A Preferred Stock
are being offered  pursuant to a prospectus  included in Registration  Statement
No. 333-15165.  Following conversion, such registered shares of Common Stock can
be sold without any holding period or sales volume limitations.

Anti-Takeover Provisions

     The  Company is  subject  to  Sections  78.411-.444  of the Nevada  General
Corporation  Law ("Nevada  Law"),  an  anti-takeover  law,  which may discourage
certain types of transactions involving an actual or potential change in control
of the Company, including transactions in which the stockholders might otherwise
receive a premium for their  shares over the current  prices,  and may limit the
ability of the stockholders to approve a transaction that they may deem to be in
their best  interests.  In addition,  the Board of Directors  has the  authority
without  action by the  stockholders  to fix the rights and  preferences  of and
issue  shares of  Preferred  Stock,  which may have the  effect of  delaying  or
preventing a change in control of the Company.

Potential Future Acquisitions

     Due to the  current  uncertainties  of the  capital  markets  for  emerging
pharmaceutical  companies,  the Company  has had  preliminary  discussions  with
several  emerging  pharmaceutical  and  biotechnology  companies about potential
business and/or product consolidations, joint ventures, acquisitions, mergers or
other business combinations (collectively "acquisitions"). In

                                        9

<PAGE>



the event the Company  undertakes any such  acquisitions  it may use some of its
cash,  including  part of the cash  received  in  connection  with  the  Private
Placement Transaction, or may issue its stock in connection therewith.  Although
management  would attempt to structure such  acquisitions  in a manner that will
minimize dilution of the equity owned by current stockholders,  no assurance can
be given that  acquisitions  will not result in such dilution or that control of
the  Company  will  not be  changed  as a  result  of  such  acquisitions.  Such
acquisitions may be negotiated or may be sought on an unsolicited  basis and may
involve  speculative and risky  undertakings by the Company with increased risks
to its stockholders. Under Nevada law, acquisitions do not require shareholders'
approval except when accomplished by merger or  consolidation.  The Company does
not, in general,  intend to submit acquisitions to shareholder vote except where
required  by Nevada  law.  The  Company  has not  entered  into any  preliminary
undertaking with any third parties  involving any acquisitions or other business
combination transactions.

Special Considerations of Doing Business in Israel

     A significant  part of the operations of the Company is conducted in Israel
through its wholly-owned  subsidiary,  Pharmos Limited ("Pharmos Ltd."),  and is
directly  affected by economic,  political  and military  conditions  there.  In
addition, Pharmos Ltd. has received certain funding from the Office of the Chief
Scientist of the Israel  Ministry of Industry and Trade (the "Chief  Scientist")
relating  to its  proprietary  SubMicron  Emulsion  Technology  and has filed an
application  to receive  funding  with  respect to  Dexanabinol,  a new chemical
entity.  Such  funding  prohibits  the  transfer or license of know-how  and the
manufacture  of resulting  products  outside of Israel without the permission of
the  Chief  Scientist.  Although  it is the  Company's  belief  that  the  Chief
Scientist does not unreasonably withhold this permission if the request is based
upon commercially  justified  circumstances  and any royalty  obligations to the
Chief Scientist are  sufficiently  assured,  there can be no assurance that such
consent,  if requested,  would be granted upon terms satisfactory to the Company
or granted at all.

Absence of Dividends

     No dividends  have been paid on the Common  Stock to date,  and the Company
does not expect to pay cash dividends in the foreseeable future.

                                    DILUTION

     As of December  31, 1996,  the net  tangible  book value of the Company was
$1,150,479  or $0.04 per share.  Net tangible book value per share is determined
by dividing the net tangible book value  (tangible  assets less  liabilities) of
the Company by the number of shares of Common Stock outstanding at that date.

     If all of the 159,000  Warrants  exercisable  at an exercise price of $1.75
per share are  exercised  (each of the Warrants  purchasing  one share of Common
Stock),  there would be 30,868,169 shares of Common Stock outstanding with a net
tangible book value of $0.05 and the  purchasers of shares  through the exercise
of such Warrants at a price of $1.75 per share would suffer  immediate  dilution
of $1.70 per share.


                                       10


<PAGE>


                                 USE OF PROCEEDS

     The Company will receive no proceeds from the  10,000,000  shares of Common
Stock to be offered and resold by the Selling Stockholders.

     Assuming that all of the 159,000 Warrants whose underlying  Common Stock is
being offered  hereby are  exercised,  the gross  proceeds to be received by the
Company will be $278,250.  Such  proceeds  will be added to working  capital and
used for general  corporate  purposes.  The amount of proceeds to be received by
the Company, however, depends on the number of Warrants exercised.

     The Company  believes that its current cash  resources and interest  income
thereon,  including the funds obtained from the Private  Placement  Transaction,
should be sufficient to fund its operating expenses and capital  requirements as
currently  planned  through  the first  quarter  of 1998 (if  combined  with the
proceeds  from the  exercise of the  Warrants,  assuming all of the Warrants are
exercised  (as to which there can be no  assurances),  the  Company  should have
sufficient  resources to fund its operating expenses and capital requirements as
currently  planned through the first quarter of 1998). The amounts and timing of
expenditures  for each  purpose  will depend on the  progress  of the  Company's
research and development programs, technological advances,  determinations as to
commercial potential,  the terms of any collaborative  arrangements entered into
by the Company for development and licensing,  regulatory  approvals,  and other
factors, many of which are beyond the Company's control.

     Pending  such  uses,  the cash  received  in  connection  with the  Private
Placement Transaction and the net proceeds from the exercise of the Warrants (if
exercised)  will be invested in short-term,  interest-bearing  investment  grade
securities. Due to the current uncertainties of the capital markets for emerging
pharmaceutical  companies  the  Company  has had  preliminary  discussions  with
several  emerging  pharmaceutical  and  biotechnology  companies about potential
acquisitions.  Any such transaction  might involve the use of the Company's cash
resources as  consideration.  The Company has not entered  into any  preliminary
understanding  with any third  parties  involving  any  acquisitions  and is not
currently in any negotiations. See "Risk Factors -- Potential Acquisitions."

                            DESCRIPTION OF SECURITIES

Common Stock

     The Common Stock being offered hereby (i) by the Selling Stockholders, (ii)
by the Company upon the exercise of the Warrants,  and (iii) by any  "affiliate"
of the Company upon the resale of such Common Stock obtained from exercising the
Warrants is fully described in the Company's  Registration Statement on Form 8-A
dated January 30, 1984, filed pursuant to Section 12 of the Securities  Exchange
Act of 1934, as amended (the  "Exchange  Act").  See  "Incorporation  of Certain
Documents by Reference".

     The Company's  Restated Articles of Incorporation  currently  authorize the
issuance of up to 50,000,000  shares of Common Stock. As of April 4, 1997, there
are currently 31,166,115


                                       11


<PAGE>



shares  outstanding,  or 36,744,602  shares taking into account  exercise of all
outstanding  stock options (and stock options which the Company is contractually
obligated to issue) and warrants (including the Warrants).

Series A Preferred Stock

     The Company's  Restated Articles of Incorporation  currently  authorize the
issuance of up to  1,250,000  shares of  Preferred  Stock.  As of April 4, 1997,
1,400 shares,  designated as Series A Preferred  Stock, are currently issued and
outstanding and held by 3 stockholders.  The Series A Preferred Stock was issued
in connection with a private placement  completed on September 30, 1996. Holders
of Series A Preferred  Stock have the right to convert  their shares as follows:
up to 25% of their initial investment after 80 days from September 30, 1996 (the
"Series A Preferred  Stock  Closing  Date"),  up to a cumulative of 75% of their
initial  investment  after 180 days from the Series A  Preferred  Stock  Closing
Date, and up to a cumulative of 100% of their initial  investment after 360 days
from the Series A Preferred  Stock  Closing  Date,  at 80% to 83% of  prevailing
market prices at time of conversion.

     Of the authorized  Preferred  Stock,  6,000 shares,  designated as Series B
Preferred   Stock,   are  currently   issued  and  outstanding  and  held  by  4
stockholders.  The Series B Preferred  Stock was issued in  connection  with the
Private  Placement  Transaction.  Holders of Series B  Preferred  Stock have the
right to convert their shares as follows:  up to 40% of their initial investment
after 90 days from March 31, 1997 (the "Series B Preferred Stock Closing Date"),
up to a cumulative  of 80% of their initial  investment  after 180 days from the
Series B Preferred  Stock Closing Date,  and up to a cumulative of 100% of their
initial  investment  after 270 days from the Series B  Preferred  Stock  Closing
Date, at prevailing market prices at time of sale.

Warrants

     The  159,000  Warrants  exercisable  at an  exercise  price  of  $1.75  are
exercisable  commencing  March 31, 1998 and expire on March 31, 2001. All of the
Warrants contain  anti-dilution  provisions providing for an adjustment to their
respective  exercise  prices in the event that the Company effects a stock split
or stock  dividend.  In addition,  the number and kind of shares of Common Stock
underlying  the Warrants are subject to  adjustments in the event of any capital
reorganization,  or  reclassification  of the capital  stock of the Company,  or
consolidation or merger of the Company with another corporation or entity (other
than a  subsidiary  of the  Company  in which the  Company is the  surviving  or
continuing corporation and no change occurs in the Company's Common Stock).

Other Securities--Preferred Stock

     The Company's  Restated Articles of Incorporation  currently  authorize the
issuance of up to 1,250,000  shares of Preferred Stock, of which 1,400 shares of
Series  A  Preferred  Stock,  issued  in  connection  with a  private  placement
completed in September 1996 and 6,000 shares of Series B Preferred  Stock issued
in connection with the Private Placement  Transaction,  are currently issued and
outstanding as of April 4, 1997, and empower the Board of Directors, without the
necessity of further action or authorization by the  stockholders,  to authorize
the


                                       12


<PAGE>



issuance of  Preferred  Stock from time to time in one or more series and to fix
the relative  rights,  preferences  and  limitations  of each such  series.  The
issuance of Preferred Stock could  adversely  affect the voting power of holders
of Common Stock and the  likelihood  that such  holders  will  receive  dividend
payments and payments  upon  liquidation  and could have the effect of delaying,
deferring or  preventing a change in control of the Company.  The Company has no
present plan to issue any additional shares of Preferred Stock.

Other Securities--Options and Warrants

     As of  December  31,  1996,  the Company had  outstanding  incentive  stock
options to purchase an aggregate of 513,253 shares of Common Stock at an average
exercise price of $2.13 per share and non-qualified stock options to purchase an
aggregate of 432,182 at an average  exercise  price of $3.12 per share issued to
employees,  directors  and  consultants  pursuant  to  stock  option  plans  and
individual  agreements with management and directors of the Company and warrants
(excluding the Warrants) to purchase  3,138,789  shares of the Company's  Common
Stock at an average price of $2.13 per share,  consisting of:  240,744  warrants
which can be  exercised  until  March 1998 each to  purchase  a single  share of
Common Stock for $2.25; 268,917 warrants which can be exercised until March 1998
each to  purchase a single  share of Common  Stock for $2.82;  333,335  warrants
which can be  exercised  until  March 1998 each to  purchase  a single  share of
Common Stock for $1.65;  406,880  warrants  which can be exercised  until August
1998 each to purchase a single share of Common Stock for $2.98;  63,913 warrants
which can be exercised  until  September 1999 each to purchase a single share of
Common Stock for $2.30;  200,000  warrants which can be exercised  until October
1999 each to purchase a single share of Common Stock for $0.84; 500,000 warrants
which can be  exercised  until  April 2005 each to  purchase  a single  share of
Common Stock for $2.75;  10,000 Warrants which can be exercised until April 2005
each to purchase a single share of Common Stock for $0.78; 15,000 warrants which
can be  exercised  until  April 2000 each to  purchase a single  share of Common
Stock for $.75;  25,000 Warrants which can be exercised until April 2000 each to
purchase a single share of Common Stock for $1.00;  25,000 warrants which can be
exercised  until April 2000 each to purchase a single  share of Common Stock for
$1.50;  900,000 warrants which can be exercised until September 14, 2000 each to
purchase a single share of Common Stock for $1.80;  10,000 warrants which can be
exercised until October 2001 each to purchase a single share of Common Stock for
$1.88;  15,000 warrants which can be exercised until March 2002 each to purchase
a single share of Common Stock for $2.31; 50,000 warrants which can be exercised
from  September  1997 until  September  2000 each to purchase a single  share of
Common Stock for $1.75;  65,000  warrants  which can be exercised from September
1997 until  September  2007 each to purchase a single  share of Common Stock for
$1.34;  and 10,000  warrants  which can be exercised  from  November  1997 until
November 2002 each to purchase a single share of Common Stock for $1.39.

Nevada Anti-Takeover Laws

         The Company is subject to the  provisions  of Sections  78.411  through
78.444 of the Nevada Law, an  anti-takeover  statute (the "Business  Combination
Statute").   In  general,   the  Business   Combination   Statute   prohibits  a
publicly-held  Nevada  corporation  from  engaging  in a  "combination"  with an
"interested stockholder" for a period of three years after the date of the

                                                        13

<PAGE>


transaction  in which the person became an interested  stockholder,  unless such
combination is approved in a prescribed  manner or satisfies  certain fair value
requirements.   For  the   purposes  of  the   Business   Combination   Statute,
"combination"  includes a merger, an asset sale, the issuance or transfer by the
corporation of its shares in one transaction or a series of transactions, having
an aggregate  fair market  value equal to five percent or more of the  aggregate
market  value  of  the  corporation's  outstanding  shares,  to  the  interested
stockholder or to an associate of the interested stockholder,  and certain other
types  of  transactions   resulting  in  a  financial   benefit  the  interested
stockholder.  An  "interested  stockholder"  is a person  who is the  beneficial
owner,  directly  or  indirectly,  of ten  percent or more of the  corporation's
voting stock or an affiliate  or associate of the  corporation  that at any time
within  the three  years  immediately  preceding  the date in  question  was the
beneficial  owner,  directly  or  indirectly,  of ten  percent  or  more  of the
corporation's voting stock.

     By an amendment to its  By-laws,  the Company has exempted  itself from the
provisions  of  Sections  78.378  through  78.3793 of the Nevada Law, a "control
share"  statute which  otherwise  prohibits an acquiring  person,  under certain
circumstances,  from voting certain shares of a target corporation's stock after
such  acquiring  person's  percentage of ownership of such  corporation's  stock
crosses  certain  thresholds,  unless  the  target  corporation's  disinterested
stockholders approve the granting of voting rights to such shares.

Transfer Agent and Registrar

     The transfer agent and registrar for the Company's Common Stock is American
Stock Transfer and Trust Company, New York, New York.

                              PLAN OF DISTRIBUTION

     The Shares offered hereby by the Selling Stockholders are 10,000,000 shares
of Common Stock issuable upon conversion of 6,000 shares  ($6,000,000  principal
amount) Series B Preferred Stock issued to the holders thereof by the Company in
connection with the Private Placement  Transaction.  This prospectus also covers
the  issuance  by the Company of up to 159,000  shares of Common  Stock upon the
exercise  of the  Warrants,  which were  issued in  connection  with the Private
Placement Transaction.

     The sale of all or a portion  of the  Shares  and  Warrant  Shares  offered
hereby by the  Selling  Stockholders  may be  effected  from time to time on the
over-the-counter  market  at  prevailing  prices at the time of such  sales,  at
prices  related to such  prevailing  prices or at negotiated  prices,  or by any
other persons  permitted under the Securities Act. The Selling  Stockholders may
effect such transactions by selling to or though one or more broker-dealers, and
such  broker-dealers  may  receive  compensation  in the  form  of  underwriting
discounts, concessions or commissions from the Selling Stockholders. The Selling
Stockholders  and any  broker-dealers  that  participate in the distribution may
under certain circumstances be deemed to be "underwriters" within the meaning of
the Securities Act, and any commissions  received by such broker-dealers and any
profits  realized  on  the  resale  of  shares  by  them  may  be  deemed  to be
underwriting discounts and commissions under the Securities Act. The Company and
the


                                       14

<PAGE>



Selling Stockholders may agree to indemnify such broker-dealers  against certain
liabilities,  including,  without  limitation,  certain  liabilities  under  the
Securities  Act, or, if such  indemnity is  unavailable,  to  contribute  toward
amounts required to be paid in respect of such liabilities.

     To the extent required under the Securities Act, a supplemental  prospectus
will be  filed,  disclosing  (a) the  name of any such  broker-dealers,  (b) the
number of shares  involved,  (c) the price at which such  shares are to be sold,
(d)  the  commissions   paid  or  discounts  or  concessions   allowed  to  such
broker-dealers,  where applicable,  (e) that such broker-dealers did not conduct
any investigation to verify the information set out or incorporated by reference
in this  prospectus,  as  supplemented,  and (f)  other  facts  material  to the
transaction.

     There is no assurance that any of the Selling Stockholders will sell any or
all of the shares of Common Stock hereby.

     The  Company  has agreed to pay  certain  costs and  expenses  incurred  in
connection  with the  registration of the shares of Common Stock offered hereby,
except  that the  Selling  Stockholders  shall be  responsible  for all  selling
commissions, transfer taxes and related charges in connection with the offer and
sale of such shares.

     The Company  has agreed to keep the  Registration  Statement  of which this
Prospectus  forms a part  continuously  effective  until the earlier of the date
that all of such  Shares  have  been sold or three  years  from the date of this
Prospectus.

                            SELLING SECURITY HOLDERS

     The table below sets forth the name of each Selling Stockholder;  the total
amount of (i) shares of Common Stock  beneficially owned by such security holder
as of April 4, 1997;  (ii)  Warrant  Shares  issuable  upon the  exercise of the
Warrants  beneficially owned by such security holder; (iii) the aggregate amount
of Common  Stock  and/or  Warrant  Shares  which may be offered for sale for the
account of such security holder in his/her discretion from time to time pursuant
to this  Prospectus;  and (iv) the amount and  percentage  of Common Stock which
would be beneficially owned by such security holder after sale of all securities
offered by the  Selling  Stockholder  pursuant to this  Prospectus,  if they are
offered and sold,  and  assuming  that any other  shares  held by such  security
holders are not sold. The information  included below is based upon  information
provided by the Selling Stockholders.  None of the Selling Stockholders referred
to herein has held any  position or office,  or had any  material  relationship,
with the Company or any of its predecessors or affiliates  within the last three
years,  except as noted below, and none of the Selling  Stockholders will own 1%
or  more  of the  outstanding  stock  of the  Company  after  completion  of the
offering, except as noted below.

     For the  purposes  of  calculating  the  number of  shares of Common  Stock
beneficially owned by the Selling  Stockholders,  the number of shares of Common
Stock  calculated to be issuable in connection with the conversion of the Series
A  Preferred  Stock and the Series B  Preferred  Stock is based on a  conversion
price of $1.00,  which is derived  from 80% of the  closing  price of the Common
Stock as of April 4,  1997.  The  calculation  of the total  number of shares of
Common Stock to be offered hereby,  however,  is based on a hypothetical  market
price of the  Common  Stock at the time of such  conversion  of $0.72  per share
(approximate  conversion price of $0.60),  which price is below the market price
of the Common Stock as of April 4, 1997

                                       15

<PAGE>


(which was  $1.25).  The use of such  hypothetical  price is not  intended,  and
should in no way be  construed,  to  constitute  a  prediction  as to the future
market price of the Common Stock.

     Because  the  initial  issuance  by the  Company of the  Warrant  Shares to
non-affiliated  holders is covered by the  Registration  Statement of which this
Prospectus  forms a part and the resale thereof by such  non-affiliated  holders
need not be registered  under the Securities  Act, the table below does not list
the warrants held by the non-affiliated Selling Stockholders.

<TABLE>
<CAPTION>
===================================================================================================================================
                                  Shares of           Amount of           Shares of
                                  Common Stock        Warrant Shares      Common Stock
             Names                Beneficially        Issuable upon       and/or Warrant       Shares and Percentage of
(and position or office held in   Owned Prior         Exercise of         Shares               Shares Owned After
the Company)                      to Offering(1)      Warrants Held       Offered(2)           Completion of Offering
                                                                                             --------------------------------------
                                                                                               Shares            Percentage(3)
===================================================================================================================================
<S>                                    <C>                      <C>                <C>              <C>                      <C>
Elliott Associates, L.P.               4,000,000(4)             106,000            6,666,667                0                   0
- -----------------------------------------------------------------------------------------------------------------------------------
Paresco, Inc.                          2,740,000(5)              42,400            2,666,667        1,140,000                3.5%
- -----------------------------------------------------------------------------------------------------------------------------------
Libertyview Fund, LLC                    155,009(6)               2,650              166,667           55,009                   *
- -----------------------------------------------------------------------------------------------------------------------------------
Libertyview Plus Fund                    505,000(7)               7,950              500,000          205,000                   *
===================================================================================================================================
</TABLE>

- --------------------

*    Indicates ownership of less than 1%

(1)  Does  not  include   warrants/and   or  options  which  are  not  currently
     exercisable, including the Warrants.

(2)  Does not  include the Warrant  Shares  because the initial  issuance by the
     Company of the Warrant Shares to  non-affiliated  holders is covered by the
     Registration Statement of which this Prospectus forms a part and the resale
     thereof by such  non-affiliated  holders need not be  registered  under the
     Securities Act.

(3)  Based on 31,166,115 shares of Common Stock outstanding as of April 4, 1997,
     plus each  individual's  shares of Common Stock issuable upon conversion of
     Series A Preferred  Stock,  and/or  currently  exercisable  warrants and/or
     options.

(4)  Based on 4,000  shares  of Series B  Preferred  Stock  held by the  Selling
     Stockholder as of April 4, 1997.

(5)  Based on 1,140  shares of  Series A  Preferred  Stock  and 1,600  shares of
     Series B  Preferred  Stock held by the Selling  Stockholder  as of April 4,
     1997.

(6)  Based on 9 shares of Common  Stock,  55 shares of Series A Preferred  Stock
     and 100 shares of Series B Preferred Stock held by the Selling  Stockholder
     as of April 4, 1997.

(7)  Based on 205 shares of Series A Preferred  Stock and 300 shares of Series B
     Preferred Stock held by the Selling Stockholder as of April 4, 1997.


                                       16


<PAGE>


                               RECENT DEVELOPMENTS

         None.

                 INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

     The  following  documents  filed by the  Company  with the  Commission  are
incorporated herein by reference:

          (a) The  Company's  Annual  Report on Form 10-K,  for the fiscal  year
     ended December 31, 1996, filed pursuant to Section 13 of the Exchange Act.

          (b) The  description  of the Common Stock  contained in the  Company's
     Registration  Statement on Form 8-A dated January 30, 1984,  filed pursuant
     to Section 12 of the Exchange Act.

     In  addition,  all reports and other  documents  to be filed by the Company
pursuant to Sections  13(a),  13(c),  14 and 15(d) of the Exchange Act, prior to
the filing of a  post-effective  amendment  which  indicates that all securities
offered hereby have been sold or which deregisters all securities offered hereby
then remaining  unsold,  as well as all such reports filed after the date hereof
and  prior  to  the  termination  of  this  offering,  shall  be  deemed  to  be
incorporated  by  reference  herein and shall be deemed to be a part hereof from
the date of the filing of each such report or document.

                     COMMISSION'S POLICY ON INDEMNIFICATION
                         FOR SECURITIES ACT LIABILITIES

     Article 12 of the Company's Restated Articles of Incorporation  directs the
Company to provide in its bylaws for provisions  relating to the indemnification
of directors  and officers to the full extent  permitted by law,  including  the
federal  securities  law.  Section  78.751 of the Nevada  Revised  Statutes,  as
amended,  authorizes  the Company to  indemnify  any  director or officer  under
certain  prescribed  circumstances  and subject to certain  limitations  against
certain costs and expenses,  including  attorneys'  fees actually and reasonably
incurred in  connection  with any action,  suit or  proceeding,  whether  civil,
criminal,  administrative or  investigative,  to which such person is a party by
reason of being a director  or officer of the Company if it is  determined  that
such person  acted in  accordance  with the  applicable  standard of conduct set
forth in such statutory  provisions.  The Company may also purchase and maintain
insurance  for the benefit of any director or officer which may cover claims for
which the Company could not indemnify such person.

     Insofar as  indemnification  for  liabilities  arising under the Act may be
permitted to directors,  officers, and controlling persons of the Company, or to
underwriters (or controlling  persons thereof) of which an officer,  partner, or
controlling  person  thereof is one of the  foregoing  pursuant to the foregoing
provisions or otherwise, the Company has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public policy
as expressed in the Act and is,  therefore,  unenforceable.  In the event that a
claim for

                                       17

<PAGE>



indemnification  against such liabilities (other than the payment by the Company
of expenses incurred or paid by any such persons,  in the successful  defense of
any action,  suit or  proceeding)  is asserted by any such persons in connection
with the securities being registered, the Company will, unless in the opinion of
its counsel the matter has been settled by  controlling  precedent,  submit to a
court of appropriate  jurisdiction the question of whether such  indemnification
by it is against  public  policy as expressed in the Act and will be governed by
the final adjudication of such issue.

                                 LEGAL OPINIONS

         Legal matters in connection  with the  securities  being offered hereby
will be passed upon for the Company by Eilenberg & Zivian, 666 Third Avenue, New
York, New York 10017.

                                     EXPERTS

     The financial  statements  incorporated  in this Prospectus by reference to
the Annual Report on Form 10-K for the year ended  December 31, 1996,  have been
so incorporated in reliance on the report of Price  Waterhouse LLP,  independent
accountants,  given on the  authority  of said firm as experts in  auditing  and
accounting.


                                       18


<PAGE>


                               PHARMOS CORPORATION

                            __________________, 1997



                                      INDEX



                                                                       Page No.


THE COMPANY ............................................................   1

RISK FACTORS ...........................................................   1

DILUTION ...............................................................  10

USE OF PROCEEDS ........................................................  11

DESCRIPTION OF SECURITIES ..............................................  11

PLAN OF DISTRIBUTION ...................................................  14

SELLING SECURITY HOLDERS ...............................................  15

RECENT DEVELOPMENTS ....................................................  17

INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE ........................  17

COMMISSION'S POLICY ON INDEMNIFICATION
FOR SECURITIES ACT LIABILITIES .........................................  17

LEGAL OPINIONS .........................................................  18

EXPERTS ................................................................  18




<PAGE>


                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution

     The following statement sets forth the estimated expenses in connection
with the offering described in the Registration Statement, assuming all of the
Warrants are exercised at their respective exercise price (all of which will be
borne by the Registrant).


Securities and Exchange Commission Fee                                   $ 4,236

Printing and Engraving Expenses                                              100

Accountants' Fees and Expenses                                             3,000

Legal Fees and Expenses                                                   40,000

Blue Sky Filing Fees                                                       1,000

Miscellaneous                                                              1,664
                                                                         -------

TOTAL                                                                    $50,000
                                                                         =======


Item 15. Indemnification of Directors and Officers.

     Article 12 of the Registrant's Certificate of Incorporation directs the
Registrant to provide in its bylaws for provisions relating to the
indemnification of directors and officers to the full extent permitted by law.
Section 78.751 of the Nevada Revised Statutes, as amended, authorizes the
Registrant to indemnify any director or officer under certain prescribed
circumstances and subject to certain limitations against certain costs and
expenses, including attorneys' fees actually and reasonably incurred in
connection with any action, suit or proceeding, whether civil, criminal,
administrative or investigative, to which such person is a party by reason of
being a director or officer of the Registrant if it is determined that such
person acted in accordance with the applicable standard of conduct set forth in
such statutory provisions.

     The Registrant may also purchase and maintain insurance for the benefit of
any director or officer which may cover claims for which the Registrant could
not indemnify such person.

Item 16. Exhibits

       4(a)   Specimen of Common Stock Certificate (incorporated by reference to
              Form S-3 Registration Statement of the Company dated November 25,
              1994 [No. 33-86720])

       4(b)   Restated Articles of Incorporation (incorporated by reference to
              Appendix E to the Joint Proxy Statement/ Prospectus included in
              the

                                      II-1

<PAGE>



              Form S-4 Registration Statement of the Registrant dated September
              28, 1992 [No. 33-52398])


       4(c)   Certificate of Amendment of Restated Articles of Incorporation
              (incorporated by reference to the Company's Annual Report on Form
              10-K for the year ended December 31, 1994 [No. 0-11550])

       4(d)   Certificate of Designation, Rights, Preferences and Privileges of
              Series A Preferred Stock of the Company (incorporated by reference
              to Form S-3 Registration Statement of the Company dated December
              20, 1996 [No. 333-15165])

       *4(e)  Certificate of Designation, Rights, Preferences and Privileges of
              Series B Preferred Stock of the Company

       4(f)   Amended and Restated By-Laws (incorporated by reference to Form S-
              1 Registration Statement of the Company dated June 30, 1994 [No.
              33- 80916])

       *4(g)  Form of 5% Preferred Stock Securities Purchase Agreement dated as
              of March 31, 1997 between the Company and the Investors

       *4(h)  Form of Stock Purchase Warrant dated as of March 31, 1997 between
              the Company and the Investors

       *5     Opinion re: legality

       23(a)  Consent of Eilenberg & Zivian (included in the Opinion filed as
              Exhibit 5)

       *23(b) Consent of Price Waterhouse LLP

- ---------------

*      Filed herewith.


Item 17. Undertakings.

     The undersigned Registrant hereby undertakes;

     (1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:

          (i) To include any prospectus required by section 10(a)(3) of the
     Securities Act of 1933;

                                      II-2

<PAGE>


          (ii) To reflect in the prospectus any facts or events arising after
     the effective date of the registration statement (or the most recent
     post-effective amendment thereof) which, individually or in the aggregate,
     represent a fundamental change in the information set forth in the
     registration statement;

          (iii) To include any material information with respect to the plan of
     distribution not previously disclosed in the registration statement or any
     material change to such information in the registration statement.

     Provided, however, that Paragraphs (i) and (ii) above do not apply if the
Registration Statement is on Form S-3 and the information required to be
included in a post-effective amendment by those paragraphs is contained in
periodic reports filed by the registrant pursuant to Section 13 or Section 15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the
Registration Statement.

     (2) That, for the purpose of determining any liability under the Securities
Act of 1933, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (3) To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
offering.

     (4) That, for the purpose of determining any liability under the Securities
Act of 1933, each filing of the registrant's annual report pursuant to Section
13(a) or 15(d) of the Securities Exchange Act of 1934 (and, where applicable,
each filing of an employee benefit plan's annual report pursuant to Section
15(d) of the Securities Exchange Act of 1934) that is incorporated by reference
in the registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Act and is,
therefore unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer, or controlling person of the Registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

                                      II-3

<PAGE>



                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Alachua and State of Florida on the 30th day of
April, 1997.
                                        PHARMOS CORPORATION

                                        By:/s/       Dr. Haim Aviv
                                           ------------------------------------
                                           Dr. Haim Aviv, Chairman, Chief
                                           Scientist, Chief Executive Officer
                                           and Director (Principal Executive
                                           Officer)

Pursuant to the  requirements of the Securities Act of 1933,  this  registration
statement or amendment  has been signed  below by the  following  persons in the
capacities and on the dates indicated:


<TABLE>
<CAPTION>
Signature                                    Title                                             Date
- ---------                                    -----                                             ----

<S>                                          <C>                                               <C> 
/s/ Alan M. Mark                             Acting Chief Financial Officer                    April 30, 1997
- ----------------------------                 (Principal Financial and Accounting
Alan M. Mark                                 Officer)                           
                                             

/s/ Dr. Gad Riesenfeld                       President, Chief Operating Officer                April 30, 1997
- ----------------------------                 and Acting Secretary
Dr. Gad Riesenfeld                           

/s/ Marvin P. Loeb                           Director                                          April 30, 1997
- ----------------------------
Marvin P. Loeb

/s/ E. Andrews Grinstead III                 Director                                          April 30, 1997
- ----------------------------
E. Andrews Grinstead III

/s/ Stephen C. Knight                        Director                                          April 30, 1997
- ----------------------------
Stephen C. Knight

/s/ David Schlachet                          Director                                          April 30, 1997
- ----------------------------
David Schlachet

/s/ Fredric D. Price                         Director                                          April 30, 1997
- ----------------------------
Fredric D. Price
</TABLE>



                                      II-4

<PAGE>




                                  EXHIBIT 4(e)

                                       E-1

<PAGE>



               CERTIFICATE OF DESIGNATION, RIGHTS, PREFERENCES AND
                     PRIVILEGES OF SERIES B PREFERRED STOCK
                                       OF
                               PHARMOS CORPORATION

                              A Nevada Corporation

     Pursuant to Nevada Revised Statutes, Section 78.1955, the undersigned
hereby certifies as follows:

          1. That he is the President and Acting Secretary of Pharmos
     Corporation, a Nevada corporation (the "Corporation"); and

          2. That, pursuant to the authority conferred on the Corporation's
     Board of Directors (the "Board") by ARTICLE IV, Section 2 of the
     Corporation's Restated Articles of Incorporation, the Board, at a special
     meeting of the Board held on March 27, 1997, (a) adopted resolutions
     providing for the issuance of shares of the Corporation's Preferred Stock
     to be designated as shares of "Series B Preferred Stock" and fixing the
     number of such shares of Series B Preferred Stock and the powers,
     designations, privileges, preferences, limitations, restrictions, price and
     relative rights of such Series B Preferred Stock as more fully set forth in
     the Statement of Designation, Rights, Preferences and Privileges of Series
     B Preferred Stock of the Corporation attached hereto and incorporated
     herein by this reference; and (b) authorized the filing of this Certificate
     with the Nevada Secretary of State.

     IN WITNESS WHEREOF, the undersigned have executed this Certificate of
Designation, Rights, Preferences and Privileges of Series B Preferred Stock of
PHARMOS CORPORATION on this 27th day of March, 1997.



                                                       /s/ Gad Riesenfeld
                                                       ------------------------
                                                       Gad Riesenfeld
                                                       President



                                                       /s/ Gad Riesenfeld
                                                       -------------------------
                                                       Gad Riesenfeld
                                                       Acting Secretary



                                       E-2

<PAGE>




STATE OF Florida   )
                         )       ss.
COUNTY OF Alachua    )

     On this 27th day of March 1997, personally appeared before the undersigned,
a Notary Public, as the President and Acting Secretary of PHARMOS CORPORATION, a
Nevada corporation, known to me to be the person described in and who executed
the foregoing instrument freely and voluntarily and for the uses and purposes
mentioned.

     IN WITNESS WHEREOF, I have hereunto set my hand and affixed my official
seal on the day and year in this certificate first written above.


                                                     /s/ Sandra V. Burgess
                                                     ---------------------------
                                                          NOTARY PUBLIC


                                       E-3

<PAGE>


                STATEMENT OF DESIGNATION, RIGHTS, PREFERENCES AND
                     PRIVILEGES OF SERIES B PREFERRED STOCK
                                       OF
                              PHARMOS CORPORATION,
                              a Nevada Corporation


     The designation, rights, preferences and privileges of, and other matters
relating to, the Company's Series B Preferred Stock or the holders ("Holders")
of record thereof are as follows:

          Section 1. Designation and Amount. The series of Preferred Stock
     designated and known as the "Series B Preferred Stock" shall have a par
     value of $.03 per share and the number of shares constituting the Series B
     Preferred Stock shall be 6,000. The Series B Preferred Stock shall have a
     stated value of $1,000 per share, with a 5% per annum dividend as set forth
     herein.

          Section 2. Rank. The Series B Preferred Stock shall rank: (i) prior to
     all of the Company's Common Stock, par value $.03 per share ("Common
     Stock"); (ii) pari passu with all the Company's Series A Preferred Stock
     ("Series A Preferred Stock"); and (iii) prior to any class or series of
     capital stock of the Company hereafter created (unless it specifically, by
     its terms, ranks on parity with the Series B Preferred Stock), in each case
     as to distributions of assets upon liquidation, dissolution or winding up
     of the Company, whether voluntary or involuntary (all such distributions
     being referred to collectively as "Distributions").

          Section 3. Dividends. The Series B Preferred Stock will bear a 5% per
     annum cumulative dividend, payable at the time of conversion in cash or
     Common Stock at the Conversion Price (as defined herein), at the Company's
     option.

          Section 4. Liquidation Preference.

          (a) In the event of any liquidation, dissolution or winding up of the
     Company, either voluntary or involuntary, the Holders of Series B Preferred
     Stock, pari passu with the Holders of Series A Preferred Stock, shall be
     entitled to receive an amount per share equal to the sum of (i) $1,000 for
     each outstanding share of Series B Preferred Stock (subject to adjustments
     for Reclassifications (as defined in herein), plus (ii) an amount equal to
     all accrued and unpaid dividends (which shall accrue through the Conversion
     Date, Redemption Date (both as defined herein) or the date liquidated
     damages are paid, as applicable) and any then unpaid liquidated damages
     (interest on which shall accrue at a rate of 2% per month) arising under
     Sections 5(c) or (g) (the "Liquidation Preference"). If upon the occurrence
     of such event, the assets and funds available to be distributed among the
     Holders of the Series B Preferred Stock shall be insufficient to permit the
     payment to such Holders of the full preferential amounts due to such
     Holders, then the entire assets and funds of the Company legally available
     for distribution shall be distributed among the Holders of the Series B and
     Series A Preferred Stock on a pro rata basis.

                                       E-4

<PAGE>




          (b) A sale, conveyance or disposition of all or substantially all of
     the assets of the Company shall be deemed to be a liquidation, dissolution
     or winding up within the meaning of this Section 4; provided further that,
     a consolidation, merger, acquisition, or other business combination of the
     Company with or into any other Company or Companies or the effectuation by
     the Company of a transaction or series of related transactions in which
     more than 50% of the voting power of the Company is disposed of shall not
     be treated as a liquidation, dissolution or winding up within the meaning
     of this Section 4, but instead shall be treated pursuant to Section
     5(i)(ii) hereof.

     Section 5. Conversion. The record Holders of this Series B Preferred Stock
shall have conversion rights as follows (the "Conversion Rights"):

          (a) Right to Convert. Each record Holder of Series B Preferred Stock
     shall be entitled to convert shares of Series B Preferred Stock (at a
     minimum of twenty (20) shares per conversion) as follows: (1) up to forty
     percent (40%) of the aggregate Liquidation Preference for the shares of
     Series B Preferred Stock held by such Holder (the "Aggregate Liquidation
     Preference") at any time beginning 91 days following the date of the
     closing of the sale of shares of Series B Preferred Stock to such Holder
     (the "Closing Date"), and at anytime thereafter; (2) up to eighty percent
     (80%) of the Aggregate Liquidation Preference at any time beginning 181
     days following the Closing Date, and at anytime thereafter; and (3) 100% of
     the Aggregate Liquidation Preference at any time beginning 271 days
     following the Closing Date, and at anytime thereafter, into that number of
     fully-paid and non-assessable shares of Common Stock of the Company
     calculated in accordance with the following formula (the "Conversion
     Rate"):

     Number of shares issued upon conversion of one (1) share of Series B
Preferred Stock =

                             Liquidation Preference
                             ----------------------
                                Conversion Price

where, "Conversion Price" means (i) an amount equal to a seventeen (17%) percent
discount from the average closing price of the Common Stock as reported by
Nasdaq for the previous three (3) business days ending on the day before the
Conversion Date (the "Average Closing Price") for the first 25% of Holder's
Aggregate Liquidation Preference converted; or (ii) an amount equal to a twenty
(20%) percent discount from the Average Closing Price for amounts converted in
excess of 25% of Holder's Aggregate Liquidation Preference. The closing price
referred to above shall be the last reported sales price, or if no reported sale
takes place on such day, the average of the closing bid and asked prices. If the
Common Stock is not traded on Nasdaq, the Average Closing Price shall be the
average closing price (and if not available, the mean of the high and low
prices) of the Common Stock on the over-the-counter-market or the principal
national securities exchange or the National Market System on which the Common
Stock is traded for the previous three (3) business days ending on the day
before the Conversion Date.

     The Conversion Price shall be equitably adjusted accordingly on a pro rata
basis in the event of the happening of certain events that would affect the
Common Stock or the Series B

                                       E-5

<PAGE>



Preferred Stock's value including, but not limited to, forward and reverse
splits, dividend payments on shares, subdivision of shares, combinations,
reclassifications, issuance of rights, warrants, options or any other event
described in Section 5(i) (collectively "Reclassifications"). An adjustment made
pursuant to this section shall become effective immediately after the effective
date of such event retroactive to the record date, if any, for such an event.

     (b) Acceleration.

     (i) If after ninety (90) days from the Closing Date, the closing bid price
on Nasdaq of the Company's Common Stock exceeds 200% of the Nasdaq closing bid
price on the Closing Date for a period of five (5) consecutive days, each Holder
may convert an additional 25% of such Holder's Aggregate Liquidation Preference.
If after ninety (90) days from the Closing Date, the closing bid price on Nasdaq
of the Company's Common Stock exceeds 300% of the closing bid price on the
Closing Date, each Holder may convert 100% of its Aggregate Liquidation
Preference without any remaining conversion restrictions.

     (ii) Each Holder may also convert 100% of its Aggregate Liquidation
Preference commencing on the date which is two weeks after any of the following
events ("Acceleration Events"), except that there shall be no such two week
delay in the event of a Change in Control Transaction or a Going Private
Transaction (both as defined herein):

          (A) the date the Company's Common Stock is delisted from the Nasdaq
     Small Cap Market and is not otherwise listed on a national securities
     exchange or the Nasdaq National Market (a "Delisting");

          (B) the date the Company (I) sells or otherwise conveys all or
     substantially all of its assets or (II) effects a transaction (by merger or
     otherwise) in which more than 50% of the voting power of the Company is
     disposed of, directly or indirectly, or if within any 12 month period there
     is a change of more than 50% of the members of the Company's Board of
     Directors, or if any affiliate of the Company or any other person, entity
     or group (as defined in Section 13(d) of the Exchange Act) acquires in
     excess of 50% of the Common Stock (collectively, a "Change in Control
     Transaction");

          (C) the date the Company completes any transaction or series of
     transactions the result of which would cause the Common Stock to cease
     being publicly traded, included without limitation pursuant to Rule 13e-3
     promulgated under the Securities Exchange Act of 1934, as amended (the
     "Exchange Act") (other than a transaction, that is not a Change in Control
     Transaction, in which the Common Stock is exchanged for other publicly
     traded securities) (a"Going Private Transaction");

          (D) the date of a suspension (a "Suspension") of the use of the
     prospectus forming part of the registration statement (the "Registration
     Statement") filed under the Securities Act of 1933, as amended (the
     "Securities Act") registering the shares of Common Stock issuable upon the
     conversion of the Series B Preferred Stock has occurred and is continuing
     or the date that is the 15th day in the aggregate that more than one

                                       E-6

<PAGE>



     Suspension has occurred since the effective date of the Registration
     Statement (a "Cumulative Suspension");

          (E) the Registration Statement is not effective 90 days after the
     Closing Date;

          (F) the date the number of authorized but unissued shares of Common
     Stock are not sufficient to effect the conversion of all outstanding shares
     of Series B Preferred Stock then eligible for conversion (whether or not
     the Holders have duly delivered Notices of Conversion) ("Insufficient
     Authorized Stock"); or

          (G) the date the Company receives a deficiency notice from the U.S.
     Food and Drug Administration (the "FDA") withdrawing approval of all
     filings by the FDA of the Company's New Drug Application submissions for
     products utilizing loteprednol etabonate.

     (c) Mechanics of Conversion. Conversion of the Series B Preferred Stock to
Common Stock may be exercised in whole or in part by Holder telecopying an
executed and completed notice of conversion ("Notice of Conversion") (in the
form annexed hereto as Exhibit A) to counsel for the Company, with a copy to the
Company, and delivering the original Notice of Conversion and the certificate
representing the shares of Series B Preferred Stock to counsel by hand or by
express courier within three (3) business days of exercise. Each date on which a
Notice of Conversion is telecopied to and received by counsel for the Company in
accordance with the provisions hereof shall be deemed a "Conversion Date." The
Company will transmit the certificates representing the Common Stock issuable
upon conversion of all or any part of the shares of Series B Preferred Stock
(together with any certificates for replacement shares of Series B Preferred
Stock not previously converted but included in the original certificate
presented for conversion) to the Holder via express courier within three (3)
business days after counsel for the Company has received the original Notice of
Conversion and certificate for the shares of Series B Preferred Stock being so
converted. The Notice of Conversion and certificate representing the portion of
the shares of Series B Preferred Stock converted shall be delivered as follows:

                           To counsel:

                           Eilenberg & Zivian
                           666 Third Avenue, 30th Fl.
                           New York, NY  10017
                           (Tele) (212) 986-2468
                           (Fax) (212) 986-2399

                           To the Company:

                           Pharmos Corporation
                           2 Innovation Drive
                           Alachua, FL  32615

                                      E-7

<PAGE>



                           Attn:  President
                           (Tele) (904) 462-1210
                           (Fax) (904) 462-5401

or to such other person at such other place as the Company shall designate to
the Holder in writing.

     In the event that the shares of Series B Preferred Stock are not converted
within three (3) business days of receipt by counsel for the Company of a valid
Notice of Conversion and certificates representing the Shares to be converted
(such date of receipt referred to as the "Conversion Date"), the Company shall
be liable to Purchaser for actual damages incurred from the fourth business day
following the Conversion Date through the ninth business day following the
Conversion Date for such failure (provided that Purchaser has delivered the
original valid Notice of Conversion and the original certificate(s) representing
the shares of Series B Preferred Stock to be converted, or an affidavit and
indemnity agreement as to lost certificates reasonably satisfactory to the
Company). In the event that the shares of Series B Preferred Stock are not
converted by the tenth (10th) business day following the Conversion Date, the
Company shall pay to the Holder, by wire transfer, as liquidated damages for
such failure and not as a penalty, an amount in cash equal to one (1%) percent
per day of the Liquidation Preference for the Series B Preferred Stock to be
converted which shall run from the initial Conversion Date; provided, however,
that actual damages and liquidated damages for a failure to deliver certificates
of Common Stock shall be determined in accordance with Section 5(g), if both of
the following conditions are satisfied by the Company: (i) the failure to
deliver certificates of Common Stock is the result of a lack of available
authorized but unissued shares of Common Stock and (ii) the Company commences,
within ten (10) business days after the initial Conversion Date, and uses its
best efforts to obtain stockholder approval to amend its Articles of
Incorporation to increase the number of authorized shares of Common Stock by an
amount sufficient to permit conversion of all shares of Series B Preferred Stock
then outstanding at the Hypothetical Conversion Price (as hereinafter defined)
then in effect.

     (i) Lost or Stolen Certificates. Upon receipt by the Company of evidence of
the loss, theft, destruction or mutilation of any certificates representing
shares of Series B Preferred Stock, and (in the case of loss, theft or
destruction) of indemnity or security reasonably satisfactory to the Company,
and upon surrender and cancellation of the certificate(s), if mutilated, the
Company shall execute and deliver new certificate(s) of like tenor and date.
However, Company shall not be obligated to re-issue such lost or stolen
certificates if Holder contemporaneously requests Company to convert such Series
B Preferred Stock into Common Stock.

     (ii) No Fractional Shares. If any conversion of the Series B Preferred
Stock would create a fractional share of Common Stock or a right to acquire a
fractional share of Common Stock, such fractional share shall be disregarded and
the number of shares of Common Stock issuable upon conversion, shall be the next
higher number of shares.


                                       E-8

<PAGE>



     (d) Restrictions on Conversion of the Series B Preferred Stock.
Notwithstanding anything to the contrary contained herein, no shares of Series B
Preferred Stock may be converted by a Holder to the extent that, after giving
effect to the shares of Common Stock issuable pursuant to a Notice of
Conversion, the total number of shares of Common Stock deemed beneficially owned
by such Holder (other than by virtue of the ownership of the Series B Preferred
Stock or the warrants issued to Holder in connection with the issuance of the
Series B Preferred Stock or ownership of other securities that have limitations
on a Holder's rights to convert or exercise similar to those limitations set
forth herein), together with all shares of Common Stock deemed beneficially
owned by Holder's "affiliates" (as defined in Rule 144 under the Securities Act)
that would be aggregated for purposes of determining whether a group under
Section 13(d) of the Exchange Act exists, would exceed 4.99% of the total issued
and outstanding shares of Common Stock, provided that each Holder shall have the
right to waive this restriction, in whole or in part, immediately in case of a
pending Change in Control Transaction (as defined in Section 5(b)(ii)(B)) and in
any other case upon 61 days prior notice to the Company. The delivery of a
Notice of Conversion by any Holder shall be deemed a representation by such
Holder it is in compliance with this Section 5(d). A transferee of the Series B
Preferred Stock shall not be bound by this provision unless it expressly agrees
to be so bound. The term "deemed beneficially owned" as used in this Section
5(d) shall exclude shares that might otherwise be deemed beneficially owned by
reason of the convertibility of the Series B Preferred Stock.

     (e) Mandatory Conversion. The Series B Preferred Stock is subject to
mandatory conversion after three (3) years from the Closing Date, at which time
all shares of Series B Preferred Stock will automatically be converted at the
Conversion Price, upon the terms set forth in this section. Such three year
period will be extended by the number of days during such period that (i) the
Company's Common Stock has been Delisted and/or (ii) a Suspension has been in
effect and by the number of days after the 90th day from the date hereof that
the Registration Statement was not declared effective. Any particular day in
which more than one of the foregoing condition events shall have been in effect
shall only be counted once in determining the number of days by which to extend
the three year period prior to mandatory conversion. Mandatory conversion shall
not occur in the event of the occurrence of one or both of the following at the
time of such mandatory conversion: (x) the Company is unable, or admits in
writing its inability, to pay its debts, or is not paying its debts generally as
they come due, or has made any assignment for the benefit of creditors; or (y)
the Company has commenced, or there has been commenced against the Company, any
case, proceeding, or other action seeking to have an order for relief entered
with respect to the Company, or to adjudicate the Company as a bankrupt or
insolvent.

     (f) Reservation of Stock Issuable Upon Conversion. The Company shall at all
times reserve and keep available out of its authorized but unissued shares of
Common Stock, such number of its shares of Common Stock as shall from time to
time be sufficient to effect the conversion of all then outstanding shares of
Series B Preferred Stock, the sufficiency of which shall be determined by using
a Conversion Price (the "Hypothetical Conversion Price") derived from a
hypothetical closing market price that is 75% of either (i) the actual Average
Closing Price on the Closing Date or (ii) the actual Average Closing Price from
time to time, whichever is lower. The Company hereby covenants and agrees that
if at any time the

                                       E-9

<PAGE>



Hypothetical  Conversion  Price  falls to a level  that  would  not  enable  all
outstanding  shares  of  Series B  Preferred  Stock to be fully  converted,  the
Company  will  promptly  use its best  efforts to obtain  stockholder  approval,
within 90 days  thereafter,  to amend its Articles of  Incorporation to increase
the  number of  authorized  shares of Common  Stock by an amount  sufficient  to
permit the conversion of all shares of Series B Preferred Stock then outstanding
at the Hypothetical Conversion Price then in effect.

     (g) Liquidated Damages. In the event of a Delisting, a Cumulative
Suspension or Insufficient Authorized Stock, or in the event the Registration
Statement is not effective within 90 days of the Closing Date (each a "Damage
Event"), the Company will pay to all Holders of the Series B Preferred Stock, by
wire transfer, as liquidated damages for such non-availability and not as a
penalty, an amount in cash equal to 2% per month of the Liquidation Preference
of only those shares of Series B Preferred Stock then eligible for conversion,
without regard to Section 5(d), for the first two months after the occurrence of
a Damage Event, and 3% per month for each month thereafter. Similar liquidated
damages shall be paid with respect to any shares of Series B Preferred Stock not
initially eligible for conversion, when the Damage Event first occurred but
which subsequently become eligible for conversion, without regard to Section
5(d), commencing in the first month that such shares of Series B Preferred Stock
become eligible for such conversion. Such liquidated damages shall continue to
accrue and shall be payable until the Damage Event has been cured (and, if
unpaid, shall bear interest at a rate of 2% per month), and, at the Holder's
election, may be paid in cash or may be added to the principal of the shares of
Series B Preferred Stock for subsequent conversion purposes; provided, however,
that in the case of a Delisting, after six months from the date of such
Delisting, the Company shall have the option to either (i) force Holder to as
promptly as possible convert (in increments of no less than $50,000) all or part
of its shares of Series B Preferred Stock, subject to Purchaser being able to
sell the underlying shares of Common Stock issuable upon conversion, and
simultaneously sell such shares (where the conversion price therefor shall not
be the Conversion Price but instead shall equal 83% of the Holder's sale price
of the shares of Common Stock issued upon conversion, for the first 25% of
Holder's Aggregated Liquidation Preference converted, and 80% of the actual sale
price of the shares of Common Stock issued upon conversion for the remainder,
all as determined by Holder's actual trading records (to be provided to the
Company) or (ii) redeem Holder's shares of Series B Preferred Stock pursuant to
Section 5(h) below. In no event, may the Company force Holder to convert less
than $50,000 of Series B Preferred Stock.

     (h) Redemption By Company.

     (i) Company's Right to Redeem. The Company shall have the right, in its
sole discretion, to redeem in whole or in part the Series B Preferred Stock when
the average Nasdaq closing bid price is more than 200% above the Nasdaq closing
price on the Closing Date for the five (5) consecutive days prior to the date
the Company makes such election to redeem. If the Company elects to redeem some,
but not all, of the shares of Series B Preferred Stock, the Company shall redeem
the shares of Series B Preferred Stock pro rata among the Holders of all of the
Series B Preferred Stock then outstanding. The date of the

                                      E-10

<PAGE>



Company's redemption of the Series B Preferred Stock shall be referred to as the
"Redemption Date."

     (ii) Redemption Price. The redemption price per share of Series B Preferred
Stock shall equal:
                         
                             Liquidation Preference
                             ----------------------
                                       80%

     (iii) Mechanics of Redemption; Holder's Conversion Rights. The Company
shall effect each such redemption by giving notice of its election to redeem
("Redemption Notice"), which shall be irrevocable, by facsimile, by 5 P.M. New
York City time the next business day following its election to redeem shares of
Series B Preferred Stock and shall provide a copy of such redemption notice by
overnight or 2-day courier, to Holder, all other Holders of shares of Series B
Preferred Stock and the Company's transfer agent for the Series B Preferred
Stock ("Transfer Agent"). Such redemption notice shall indicate (i) whether the
Company will redeem all or part of the Series B Preferred Stock, (ii) the
applicable redemption price and (iii) that the average Nasdaq closing bid price
has exceeded by 200% the Nasdaq closing price on the Closing Date for the five
(5) consecutive days prior to the date the Company elects to redeem shares of
Series B Preferred Stock. Notwithstanding the foregoing, Holder shall have five
business days following receipt of the Redemption Notice from the Company to
elect, in its sole discretion, to convert all or part of the Series B Preferred
Stock otherwise being redeemed. Such conversion shall be effected in accordance
with the Certificate of Designation, and if an appropriate Notice of Conversion
is delivered to the Company in a timely manner, such shares of Series B
Preferred Stock shall be deemed to be converted and not redeemed.

     (iv) Company Must Have Immediately Available Funds or Credit Facilities.
The Company shall not be entitled to send any Redemption Notice and begin the
redemption procedure hereunder unless it has:

          (A) the full amount of the redemption price in cash, available in a
     demand or other immediately available account in a bank or similar
     financial institution; or

          (B) immediately available credit facilities, in the full amount of the
     redemption price with a bank or similar financial institution; or

          (C) a combination of the items set forth in (A) and (B) above,
     aggregating the full amount of the redemption price.

     (v) Payment of Redemption Price. Upon receipt of a Redemption Notice Holder
shall send its shares of Series B Preferred Stock being redeemed to the Company
or its Transfer Agent, and the Company shall pay the applicable redemption price
within three (3) business days of receipt of the shares of Series B Preferred
Stock. The Company shall not be obligated to deliver the redemption price unless
the shares of Series B Preferred Stock so redeemed are delivered to the Company
or its Transfer Agent, or, in the event one or more certificates have been lost,
stolen, mutilated or destroyed, Holder delivers to the

                                      E-11

<PAGE>



Company a lost certificate affidavit and indemnification agreement reasonably
satisfactory to Company and the Transfer Agent.

     (vi) Blackout Period. Notwithstanding the foregoing, the Company may not
either send out a redemption notice or effect a redemption during a Blackout
Period (defined as a period during which the Company's officers or directors
would not be entitled to buy or sell stock because of their holding of material
non-public information). In the event the Company initiates a redemption during
a Blackout Period without having first made public material non-public
information, the Company shall disclose the non-public information that resulted
in the Blackout Period, and no redemption shall be effected until at least 10
days after the Company shall have given the Holder written notice that the
Blackout Period has been lifted.

     (i) Adjustment to Conversion Rate.

     (i) Adjustment to Fixed Conversion Price Due to Stock Split, Stock
Dividend, Etc. If at any time when the Series B Preferred Stock is issued and
outstanding, the number of outstanding shares of Common Stock is increased by a
stock split, stock dividend, or other similar event, the Conversion Price shall
be proportionately reduced, or if the number of outstanding shares of Common
Stock is decreased by a reverse stock split, combination or reclassification of
shares, or other similar event, the Conversion Price shall be proportionately
increased. In such event the Company shall notify the Transfer Agent of such
change on or before the effective date thereof.

     (ii) Adjustment Due to Merger, Consolidation, Etc. If, prior to the
conversion of all Series B Preferred Stock, there shall be any merger,
consolidation, exchange of shares, recapitalization, reorganization, or other
similar event, as a result of which shares of Common Stock of the Company shall
be changed into the same or a different number of shares of the same or another
class or classes of stock or securities of the Company or another entity, or
other property, then the Holders of Series B Preferred Stock shall, upon being
given at least 30 days advance written notice of such transaction, thereafter
have the right to purchase and receive upon conversion of Series B Preferred
Stock, upon the basis and upon the terms and conditions specified herein and in
lieu of the shares of Common Stock immediately theretofore issuable upon
conversion, such shares of stock and/or securities or other property as may be
issued or payable with respect to or in exchange for the number of shares of
Common Stock immediately theretofore purchasable and receivable upon the
conversion of Series B Preferred Stock held by such Holders had such merger,
consolidation, exchange of shares, recapitalization or reorganization not taken
place, and in any such case appropriate provisions shall be made with respect to
the rights and interests of the Holders of the Series B Preferred Stock to the
end that the provisions hereof (including, without limitation, provisions for
adjustment of the Conversion Rate and of the number of shares issuable upon
conversion of the Series B Preferred Stock) shall thereafter be applicable, as
nearly as may be practicable in relation to any shares of stock or securities
thereafter deliverable upon the conversion thereof. The Company shall not effect
any transaction described in this subsection 5(f) unless (1) Holder has been
given at least 30 days advance written notice of such transaction, and (2) the
resulting successor or acquiring entity

                                      E-12

<PAGE>



(if not the Company) assumes by written  instrument the obligation to deliver to
the  Holders  of the  Series B  Preferred  Stock  such  shares  of stock  and/or
securities or other  property as, in accordance  with the foregoing  provisions,
the  Holders of the Series B Preferred  Stock may be  entitled  to receive  upon
conversion of the Series B Preferred Stock.

     (iii) No Fractional Shares. If any adjustment under this Section 5(i) would
create a fractional share of Common Stock or a right to acquire a fractional
share of Common Stock, such fractional share shall be disregarded and the number
of shares of Common Stock issuable upon conversion shall be the next higher
number of shares.

     Section 6. Voting Rights. The Holders of the Series B Preferred Stock shall
have no voting power whatsoever, except with respect to any amendment to the
Company's Certificate of Incorporation which would have an adverse effect on the
Series B Preferred Stock or as otherwise provided by the Nevada Corporation
Laws.

     Section 7. Status of Converted Stock. In the event any shares of Series B
Preferred Stock shall be converted pursuant to Section 5 hereof, the shares so
converted shall be canceled, shall return to the status of authorized but
unissued Preferred Stock of no designated series, and shall not be issuable by
the Company as Series B Preferred Stock.

     Section 8. Preference Rights. Nothing contained herein shall be construed
to prevent the Board of Directors of the Company from issuing one or more series
of Preferred Stock with dividend and/or liquidation preferences junior to the
dividend and liquidation preferences of the Series B Preferred Stock.



                                      E-13

<PAGE>



                                                                       EXHIBIT A

                              NOTICE OF CONVERSION
        (To be Executed by the Registered Holder in order to Convert the
                               5% Preferred Stock)

The undersigned hereby  irrevocably elects to convert the ___Shares  represented
by above Certificate No. ____ into shares of common stock of PHARMOS CORPORATION
(the  "Company")  according  to the  conditions  hereof,  as of the date written
below.

The undersigned represents and warrants that

     All  offers  and sales by the  undersigned  of the  shares of Common  Stock
     issuable to the undersigned upon conversion of the Preferred Stock shall be
     made pursuant to an exemption from registration  under the Act, or pursuant
     to  registration  of the Common Stock under the  Securities Act of 1933, as
     amended.


- --------------------------------                --------------------------------
Date of Conversion                              Applicable Conversion Price


- --------------------------------                --------------------------------
Number of Shares of Common Stock                $ Amount of Conversion
upon Conversion



- -----------------------------                   -------------------------------
Signature                                       Name

Address:                                        Delivery of Shares to:

                             E-14

<PAGE>




                                                                    EXHIBIT 4(g)





                                      E-15

<PAGE>



           [FORM OF 5% PREFERRED STOCK SECURITIES PURCHASE AGREEMENT]

THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE UNITED STATES  SECURITIES AND
EXCHANGE  COMMISSION OR THE  SECURITIES  COMMISSION OF ANY STATE  PURSUANT TO AN
EXEMPTION FROM REGISTRATION  UNDER REGULATION D PROMULGATED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE  "SECURITIES  ACT").  THIS  SUBSCRIPTION  AGREEMENT
SHALL NOT CONSTITUTE AN OFFER TO SELL NOR A SOLICITATION  OF AN OFFER TO BUY THE
SECURITIES  IN ANY  JURISDICTION  IN WHICH SUCH OFFER OR  SOLICITATION  WOULD BE
UNLAWFUL.  THE SECURITIES ARE  "RESTRICTED" AND MAY NOT BE RESOLD OR TRANSFERRED
EXCEPT  AS  PERMITTED  UNDER  THE ACT  PURSUANT  TO  REGISTRATION  OR  EXEMPTION
THEREFROM.

                               5% PREFERRED STOCK
                          SECURITIES PURCHASE AGREEMENT

                               PHARMOS CORPORATION

     THIS AGREEMENT is made as of the 31st day of March,  1997,  between PHARMOS
CORPORATION,  Nasdaq Symbol "PARS" (the "Company"),  a Nevada corporation,  with
its principal office at 2 Innovation Drive, Alachua, FL 32615, and _____________
(the       "Purchaser"),       with      its      principal       office      at

- ----------------------------------------------------.

     IN CONSIDERATION of the mutual covenants  contained in this Agreement,  the
Company and the Purchaser agree as follows:

     Section 1. Certain Definitions. For purposes of this Agreement:

          "Closing  Date"  means  the  date  agreed  to by the  parties  for the
     delivery of the stock  certificate  against a wire transfer of the funds to
     the Company.

          "Closing"  means the completion of the purchase and sale of the Shares
     on the Closing Date.

          "Common Stock" means the underlying Common Stock of the Company,  $.03
     par value.

          "Conversion Date" means the date on which the Purchaser has telecopied
     the Notice of Conversion to counsel for the Company.

          "Convertible  Preferred  Stock" means the shares of Series B Preferred
     Stock of the  Company,  $.03 par value,  convertible  into Common  Stock as
     hereinafter  provided and which has the rights,  preferences and privileges
     set forth in the  Certificate of Designation  attached  hereto as Exhibit A
     (the "Certificate of Designation").

                                      E-16

<PAGE>


          "Conversion  Price" means an amount equal to a seventeen (17%) percent
     discount  from the closing  price of the Common Stock as reported by Nasdaq
     averaged for the previous  three (3) business days ending on the day before
     the  Conversion  Date (the  "Average  Closing  Price") for the first 25% of
     Purchaser's Aggregate  Liquidation  Preference (as defined herein); and for
     amounts  converted in excess of 25% of  Purchaser's  Aggregate  Liquidation
     Preference,  the discount  shall be twenty  (20%)  percent from the Average
     Closing  Price.  The  closing  price  referred  to above  shall be the last
     reported  sales price,  or if no reported sale takes place on such day, the
     average of the closing  bid and asked  prices.  If the Common  Stock is not
     traded on Nasdaq,  the Average  Closing Price shall be the average  closing
     price (and if not  available,  the mean of the high and low  prices) of the
     Common  Stock  on the  over-the-counter-market  or the  principal  national
     securities exchange or the National Market System on which the Common Stock
     is traded for the previous three (3) business days ending on the day before
     the Conversion Date.

          The Conversion Price shall be equitably adjusted  accordingly on a pro
     rata  basis in the event of the  happening  of  certain  events  that would
     affect the Common Stock or Convertible  Preferred  Stock's value including,
     but not  limited  to,  forward and  reverse  splits,  dividend  payments on
     shares, subdivision of shares, combinations, reclassifications, issuance of
     rights, warrants,  options or the like (collectively  "Reclassifications").
     An  adjustment  made  pursuant  to  this  section  shall  become  effective
     immediately  after the  effective  date of such  event  retroactive  to the
     record date, if any, for such an event.

          "Purchase  Price"  means the  aggregate  purchase  price of the Shares
     purchased.

          "Shares" means the shares of  Convertible  Preferred  Stock  purchased
     hereunder.

          Section 2. Authorization and Sale of Shares.

     2.1  Authorization.  Subject to the terms and conditions of this Agreement,
the Company has authorized the sale and issuance of the Shares.

     2.2  Agreement to Sell and  Purchase the Shares.  The Company will sell and
the  Purchaser  will  buy  Shares  in  reliance  upon  the  representations  and
warranties of the Company and Purchaser  contained in this  Agreement,  upon the
terms  and  conditions  hereinafter  set  forth,  _____  shares  of  Convertible
Preferred   Stock   for  an   aggregate   purchase   price  of   _______________
_____________________________ Dollars based on U.S. $1,000 per share. The Shares
shall pay a 5%  cumulative  dividend,  payable  in cash or  Common  Stock at the
Conversion  Price,  at the  discretion  of the  Company,  at the  time  of  each
conversion. Such purchase and sale shall occur on the Closing Date. In addition,
Company  will  issue  to  Purchaser,  for no  additional  consideration,  ______
four-year warrants ("Warrants") to purchase Common Stock,  initially exercisable
on the first  anniversary  of the date  hereof  and for a period of three  years
thereafter,  at an  exercise  price of  $1.75  per  share as per the  terms of a
separate Stock Purchase Warrant.


                                      E-17

<PAGE>


     2.3 Time and Place of Closing.  The Closing shall be held at the offices of
Eilenberg  & Zivian,  666 Third  Avenue,  New York,  NY 10016,  as  promptly  as
practicable  as agreed to by the  parties to this  Agreement,  but no later than
April 4, 1997 at which time either party may terminate this Agreement.

     2.4 Payment and Delivery.  At or prior to the Closing,  the following shall
occur:

          (a)  Purchaser  shall remit by wire  transfer  the  Purchase  Price as
     payment in full for the Shares to, at its discretion, either (i) Sheldon E.
     Goldstein, P.C. ("Escrow Agent"), counsel for certain purchasers of Shares,
     as per a separate escrow agreement between Escrow Agent and the Company, or
     (ii) directly to the Company,  provided that Purchaser has been notified by
     Eilenberg & Zivian that the Company has delivered certificates representing
     the Shares and Warrants as provided in Section 2.4(b) below.

          (b) Company shall deliver or cause to be delivered to Escrow Agent (or
     to  Eilenberg & Zivian if  Purchaser  has elected to pay Company  directly)
     certificates  representing  the Shares and the Warrants,  registered in the
     name of Purchaser  (or any nominee  designated by Purchaser at prior to the
     Closing  Date),  free  and  clear  of  all  liens,   claims,   charges  and
     encumbrances.  Purchaser shall receive such  certificates from Escrow Agent
     or Eilenberg & Zivian,  as  applicable,  after the Company has received the
     Purchase  Price from the Escrow Agent or directly  from  Purchaser,  as the
     case may be.

          (c) Wire instructions for Sheldon E. Goldstein, P.C. are as follows:

            Chase Manhattan Bank, N.A.
            ABA #021000021
            For the Account of
             United States Trust Company of New York
             Account #920-1-073195
            In Favor of
             Sheldon E. Goldstein, P.C. Attorney Trust Account
             Account #59-02347

          (d) Wire instructions for the Company are as follows:

            State Street Bank & Trust Company
            108 Myrtle Street
            North Quincy, MA
            ABA Routing #: 011000028
            Credit DDA #:  56730328
            Account #:     DE0175
            Account Name:  Pharmos Corporation


                                      E-18

<PAGE>


     Section 3. General  Representations  and  Warranties  of the  Company.  The
Company  hereby  represents  and warrants to, and covenants  with, the Purchaser
that the  following  are true and  correct  as of the date  hereof and as of the
Closing Date.

     3.1  Organization;   Qualification.  The  Company  is  a  corporation  duly
organized and validly  existing  under the laws of the State of Nevada and is in
good standing under such laws. The Company has all requisite corporate power and
authority to own, lease and operate its  properties and assets,  and to carry on
its business as presently conducted.  The Company is qualified to do business as
a  foreign  corporation  in each  jurisdiction  in which  the  ownership  of its
property or the nature of its business requires such qualification, except where
failure to so qualify would not have a material adverse effect on the Company.

     3.2 Capitalization. The authorized capital stock of the Company consists of
50,000,000  Shares of Common Stock,  $.03 par value, of which 31,095,510  shares
are  currently  issued  and  outstanding,  and  1,250,000  Shares of  non-voting
Preferred  Stock,  $.03 par value,  of which 1,900  shares have been  designated
Series A Preferred Stock ("Series A Stock"),  $.03 par value, and of which 1,460
shares are currently issued and outstanding, and of which 6,000 shares have been
designated  Series B Preferred Stock, par value $.03. All issued and outstanding
shares of Common  Stock have been duly  authorized  and  validly  issued and are
fully paid and  nonassessable.  The Company will reserve from its authorized but
unissued shares of Common Stock a sufficient number of shares of Common Stock to
permit the conversion in full of the outstanding Shares and the exercise in full
of the  Warrants.  As of the Closing Date,  the Company had reserved  sufficient
shares of Common  Stock for  issuance  upon  exercise  of the  Shares  which are
convertible, at Purchaser's option, at the Conversion Price, as per Section 9 of
this Agreement, and upon exercise of the Warrants.

     3.3 Authorization. The Company has all requisite corporate right, power and
authority  to  execute  and  deliver  this   Agreement  and  to  consummate  the
transactions  contemplated  hereby.  All  corporate  action  on the  part of the
Company,  its  directors  and  stockholders  necessary  for  the  authorization,
execution,  delivery and  performance  of this  Agreement  by the  Company,  the
authorization,  sale, issuance and delivery of the Shares and the performance of
the Company's obligations hereunder has been taken. This Agreement has been duly
executed and delivered by the Company and constitutes a legal, valid and binding
obligation of the Company  enforceable in accordance with its terms,  subject to
laws of general application relating to bankruptcy, insolvency and the relief of
debtors and rules of law governing  specific  performance,  injunctive relief or
other equitable remedies,  and to limitations of public policy as they may apply
to the  indemnification  provisions set forth in Section 7.4 of this  Agreement.
Upon their  issuance  and  delivery  pursuant  to this  Agreement,  the  Shares,
Warrants and shares of Common Stock issuable upon  conversion of the Shares (the
"Conversion  Shares")  and  exercise  of  the  Warrants  (the  "Warrant  Shares)
(collectively,  the  "Securities")  will  be  validly  issued,  fully  paid  and
nonassessable and will be free of any liens or encumbrances;  provided, however,
that the Shares and Warrants are subject to restrictions on transfer under state
and/or federal securities laws. The issuance and sale of the Shares and Warrants
will not give rise to any preemptive right or right of first refusal or right of
participation  on behalf of any  person.  Upon  registration  of the  Conversion
Shares and the Warrant Shares pursuant to Section 7 of this

                                      E-19

<PAGE>



Agreement,  there shall be no restriction on the  transferability  thereof other
than applicable prospectus delivery requirements.

     3.4 No Conflict.  The execution and delivery of this  Agreement do not, and
the  consummation of the  transactions  contemplated  hereby will not,  conflict
with, or result in any violation of, or default (with or without notice or lapse
of time,  or both),  or give  rise to a right of  termination,  cancellation  or
acceleration of any obligation or to a loss of a material  benefit,  under,  any
provision of the Articles of Incorporation,  and any amendments thereto, Bylaws,
stockholders  agreements  and  any  amendments  thereto  of the  Company  or any
material mortgage,  indenture,  lease or other agreement or instrument,  permit,
concession, franchise, license, judgment, order, decree statute, law, ordinance,
rule or regulation applicable to the Company, its properties or assets.

     3.5 Accuracy of Reports and Information. The Company is in full compliance,
to the extent applicable, with all reporting obligations under Section 12(b), 12
(g) or 15(d), as applicable,  of the Securities Exchange Act of 1934, as amended
(the  "Exchange  Act").  The Company has registered its Common Stock pursuant to
Section  12 of the  Exchange  Act and the  Common  Stock is listed and trades on
Nasdaq.

     The Company  has filed all  material  required to be filed  pursuant to all
reporting  obligations,  under either Section 13(a) or 15(d) of the Exchange Act
for a period of at least twelve (12) months  immediately  preceding the offer or
sale of the  Shares  (or for  such  shorter  period  that the  Company  has been
required to file such material).

     3.6 SEC  Filings/Full  Disclosure.  None of the Company's  filings with the
Securities  and  Exchange  Commission  since  January 1, 1996 contain any untrue
statement of a material  fact or omit to state any material  fact required to be
stated  therein  or  necessary  to make the  statements  therein in light of the
circumstances under which they were made, not misleading. The Company has, since
January 1, 1996, timely filed all requisite forms,  reports and exhibits thereto
with the Securities and Exchange Commission ("SEC"). The Company's Annual Report
on Form 10-K for the year  ended  December  31,  1995  (the  "1995  10-K"),  its
Quarterly Reports for the periods ended March 31, June 30 and September 30, 1996
and all Current Reports on Form 8-K filed by the Company from January 1, 1996 to
date are referred to as the "SEC Reports."

     There  is no  fact  known  to the  Company  (other  than  general  economic
conditions known to the public generally) that has not been disclosed in writing
to the Purchaser which could  reasonably be expected to have a material  adverse
effect on the condition  (financial  or otherwise) or in the earnings,  business
affairs, business prospects,  properties or assets of the Company, or (ii) could
reasonably  be expected to materially  and  adversely  affect the ability of the
Company to perform its obligations pursuant to this Agreement.

     3.7  Absence  of  Undisclosed  Liabilities.  The  Company  has no  material
liabilities  or  obligations,  absolute or  contingent  (individually  or in the
aggregate),  except as set forth in the financial statements included in the SEC
Reports or in the current draft of the Company's  Annual Report on Form 10-K for
the fiscal year ended December 31, 1996 (the

                                      E-20

<PAGE>



"Draft  1996  10-K")  provided to the  Purchaser  pursuant to a  confidentiality
agreement  and being  filed  with the SEC on March 31,  1997  (collectively  the
"Financial  Statements") or as incurred in the ordinary course of business after
the date of the Financial Statements.

     3.8 Governmental Consent, etc. No consent,  approval or authorization of or
designation,  declaration or filing with any governmental  authority on the part
of the Company is required in connection  with the valid  execution and delivery
of  this  Agreement,  or the  offer,  sale or  issuance  of the  Shares,  or the
consummation of any other  transaction  contemplated  hereby,  except the filing
with  the SEC of a  registration  statement  on Form  S-3  for  the  purpose  of
registering the Common Stock underlying the Shares and the Warrants.

     3.9 Intellectual Property Rights. Except as disclosed in the SEC Reports or
the Draft 1996 10-K, the Company has sufficient trademarks,  trade names, patent
rights, copyrights and licenses to conduct its business as contemplated therein.
To the Company's  knowledge,  neither the Company nor its products is infringing
or will infringe any trademark,  trade name, patent right,  copyright,  license,
trade secret or other similar right of others currently in existence;  and there
is no claim being made against the Company regarding any trademark,  trade name,
patent,  copyright,  license,  trade secret or other intellectual property right
which  could have a  material  adverse  effect on the  condition  (financial  or
otherwise), business, results of operations or prospects of the Company.

     3.10  Material  Contracts.  Except as set forth in the SEC  Reports  or the
Draft 1996  10-K,  the  agreements  to which the  Company  is a party  described
therein are valid  agreements,  in full force and effect,  the Company is not in
material breach or material default (with or without notice or lapse of time, or
both) under any of such agreements,  and, to the Company's knowledge,  the other
contracting  party or parties  thereto  are not in  material  breach or material
default  (with or without  notice or lapse of time,  or both)  under any of such
agreements.

     3.11 Litigation.  There is no action,  proceeding or investigation pending,
or to the  Company's  knowledge  threatened,  against  the  Company  which might
result, either individually or in the aggregate,  in any material adverse change
in the business,  prospects,  conditions,  affairs or operations of the Company.
The Company is not a party to or subject to the  provisions of any order,  writ,
injunction,   judgment  or  decree  of  any  court  or   government   agency  or
instrumentality.  There is no action,  suit,  proceeding or investigation by the
Company currently pending or which the Company currently intends to initiate.

     3.12 Title to Assets.  Except as set forth in SEC Reports or the Draft 1996
10-K, the Company has good and  marketable  title to all properties and material
assets  described  therein as owned by it, free and clear of any  pledge,  lien,
security interest,  encumbrance,  claim or equitable interest other than such as
are not material to the business of the Company.

     3.13 Subsidiaries.  The Company does not presently own or control, directly
or indirectly, any interest in any other corporation,  partnership,  association
or other business entity,  except as stated in the SEC Reports or the Draft 1996
10-K.


                                      E-21

<PAGE>



     3.14  Required  Governmental  Permits.  The Company is in possession of and
operating  in  compliance  with  all  authorizations,   licenses,  certificates,
consents,   orders  and  permits  from  state,   federal  and  other  regulatory
authorities which are material to the conduct of its business,  all of which are
valid and in full force and effect.

     3.15 Listing.  The Company will maintain the listing of its Common Stock on
the Nasdaq Small Cap Market or other organized,  comparable United States market
or quotation system;  provided,  however, that the sole remedy for Purchaser for
breach of this representation shall be liquidated damages as provided in Section
9.6.

     3.16 Other Outstanding  Securities/Financing  Restrictions.  Except for the
outstanding  shares of Series A Stock and  outstanding  non-vested  warrants  to
purchase  1,130,000  shares of Common Stock issued to employees in February 1997
and except as  disclosed  in the  September  30,  1996 10-Q,  there are no other
outstanding  debt or equity  securities  presently  convertible  into  shares of
Common Stock. The Company has no outstanding  restricted shares of Common Stock,
or shares of Common  Stock sold under  Regulation  S or  Regulation  D under the
Securities Act of 1933, as amended (the "Securities  Act") or outstanding  under
any  other  exemption  from  registration,  which  are  available  for  sale  as
unrestricted ("free trading") stock.

     The  Company  cannot,  without  the  prior  approval  in  writing  from the
Purchaser,  obtain  convertible  debt or  equity  financing  for a period of one
hundred eighty (180) days following the Closing Date; however,  the Company will
not require prior approval if (a) the Company's share price is greater than 200%
of the Closing Price at the time of such financing,  (b) the financing is with a
company or entity with which the Company has, or is entering into, a business or
strategic  relationship,  or (c) the equity securities issued are not registered
prior to 180 days from the Closing Date.

     3.17 Right of First Refusal.  In the event the Company wishes to complete a
financing  similar in  structure  to the  securities  issued  hereby  within one
hundred and eighty (180) days from the Closing Date,  the  Purchaser  shall have
the right of first refusal to  participate in such offering and shall have three
(3) business days to reply in writing  after  receipt of written  notice of such
proposed  financing from the Company.  In the event a writing is not received by
the Company, this will be deemed a refusal by the Purchaser.

     3.18 Legal Opinion.  Purchaser shall, upon purchase of the Shares,  receive
an opinion letter from counsel to the Company,  and the Company  represents that
it will  immediately  obtain such an opinion from counsel to the satisfaction of
the Purchaser, to the effect that:

          (a) The Company is duly  incorporated,  validly  existing  and in good
     standing in the jurisdiction of its incorporation.

          (b) There is no action,  proceeding or  investigation  pending,  or to
     such  counsel's  knowledge,  threatened  against  the  Company  which might
     result,  either  individually or in the aggregate,  in any material adverse
     change in the business, prospects, conditions, affairs or operations of the
     Company.


                                      E-22

<PAGE>



          (c) The Company is not a party to or subject to the  provisions of any
     order,  writ,  injunction,  judgment  or decree of any court or  government
     agency or instrumentality.

          (d) There is no  action,  suit,  proceeding  or  investigation  by the
     Company  currently  pending  or which  the  Company  currently  intends  to
     initiate.

          (e) All issued and  outstanding  shares of Common Stock have been duly
     authorized and validly issued and are fully paid and nonassessable.

          (f) This Securities Purchase Agreement and the Stock Purchase Warrant,
     the issuance of the Shares and Warrants and the issuance of the  Conversion
     Shares and Warrant Shares have been duly approved by all required corporate
     action and that all such Securities, upon delivery, shall be validly issued
     and outstanding, fully paid and nonassessable.

          (g)  The  execution,  delivery  and  performance  of  this  Securities
     Purchase  Agreement and the Stock Purchase Warrant by the Company,  and the
     consummation of the transactions  contemplated  thereby,  will not, with or
     without the giving of notice or the passage of time or both:

               (i)  Violate  the  provisions  of any  law,  rule  or  regulation
          applicable to the Company;

               (ii)  Violate  the  provisions  of the  charter  or bylaws of the
          Company; or

               (iii) To the best of counsel's  knowledge,  violate any judgment,
          decree, order or award of any court, governmental body or arbitrator.

               (iv) To the best of counsel's knowledge, conflict with, or result
          in the  breach  or  termination  of  any  term  or  provision  of,  or
          constitute a default under, or cause any acceleration  under, or cause
          the creation of any lien, charge or encumbrance upon the properties or
          assets  of  the  Company  pursuant  to,  any  note,  bond,  indenture,
          mortgage,  lease,  deed of trust or other instrument,  obligation,  or
          agreement to which the Company is a party or by which the Company,  or
          any of its properties is or may be bound.

          (h) This Securities  Purchase Agreement and the Stock Purchase Warrant
     constitute the valid and legally binding obligations of the Company and are
     enforceable  against the Company in accordance with their respective terms,
     subject to laws of general application  relating to bankruptcy,  insolvency
     and the relief of debtors and rules of law governing specific  performance,
     injunctive relief or other equitable remedies, and, with

                                      E-23

<PAGE>



     respect to the  Securities  Purchase  Agreement,  to  limitations of public
     policy as they may  apply to the  indemnification  provisions  set forth in
     Section 7.4 thereof.

     3.19 Use of Proceeds.  The Company  represents  that the net proceeds  from
this  offering  will be used to fund  the  Company's  research  and  development
activities and clinical trials of its drugs,  possible  acquisitions,  strategic
alliances, working capital and general corporate purposes.

     3.20 No Poison Pill. The Company  represents that it does not have, and has
no current intention to adopt, a stockholder rights plan ("poison pill").

     Section 4. Representations,  Warranties and Covenants of the Purchaser. The
Purchaser  represents and warrants to, and covenants  with, the Company that the
following are true and correct as of the date hereof and as of the Closing Date.

     4.1 Authority.  The Purchaser's  signatory has all right, power,  authority
and  capacity  to execute and  deliver  this  Agreement  and to  consummate  the
transactions  contemplated  hereby.  This  Agreement  has been duly executed and
delivered by the  Purchaser  and will  constitute  the legal,  valid and binding
obligations of the Purchaser,  enforceable in accordance with its terms, subject
to laws of general application relating to bankruptcy, insolvency and the relief
of debtors and rules of law governing specific performance, injunctive relief or
other equitable remedies,  and to limitations of public policy as they may apply
to the indemnification provisions set forth in Section 7.4 of this Agreement.

     4.2 Investment Experience. Purchaser is an "accredited investor" as defined
in Rule 501(a) under the  Securities  Act.  Purchaser is aware of the  Company's
business affairs and financial  condition and has had access to and has acquired
sufficient information about the Company, including the SEC Reports, to reach an
informed and  knowledgeable  decision to acquire the Shares.  Purchaser has such
business  and  financial  experience  as is required to give it the  capacity to
protect its own interests in connection  with the purchase of the Shares and the
acquisition of the Warrants.

     4.3 Investment  Intent.  Without  limiting its ability to resell the Shares
and  the  Warrants  and  underlying   Common  Stock  pursuant  to  an  effective
registration  statement,  Purchaser  represents that it is purchasing the Shares
for  investment  purposes.  Purchaser  understands  that its  acquisition of the
Shares and the  Warrants has not been  registered  under the  Securities  Act or
registered or qualified  under any state  securities law in reliance on specific
exemptions therefrom,  which exemptions may depend upon, among other things, the
bona fide nature of Purchaser's investment intent as expressed herein. Purchaser
will not, directly or indirectly,  offer,  sell,  pledge,  transfer or otherwise
dispose of (or solicit any offers to buy,  purchase or otherwise acquire or take
a pledge of) any of the Shares or the  Warrants  except in  compliance  with the
Securities  Act and any  applicable  state  securities  laws,  and the rules and
regulations promulgated thereunder.

     4.4 Registration or Exemption Requirements.  Purchaser further acknowledges
and understands  that the Shares and the Warrants may not be resold or otherwise
transferred

                                      E-24

<PAGE>



except in a transaction  registered  under the Securities Act and any applicable
state  securities  laws  or  unless  an  exemption  from  such  registration  is
available.  Purchaser understands that the certificate(s)  evidencing the Shares
and the Warrants will be imprinted with a legend,  subject to Section 4.7 below,
that  prohibits  the transfer  thereof  unless (i) they are  registered  or such
registration  is not  required,  and  (ii) if the  transfer  is  pursuant  to an
exemption from registration other than Rule 144 under the Securities Act and, if
the  Company  shall so request  in  writing,  an  opinion of counsel  reasonably
satisfactory to the Company is obtained to the effect that the transaction is so
exempt.

     4.5 No Legal, Tax or Investment Advice.  Purchaser understands that nothing
in this  Agreement or any other  materials  presented to Purchaser in connection
with the purchase and sale of the Shares and the acquisition and issuance of the
Warrants  constitutes legal, tax or investment  advice.  Purchaser has consulted
such  legal,  tax and  investment  advisors as it, in its sole  discretion,  has
deemed  necessary or appropriate  in connection  with its purchase of the Shares
and acquisition of the Warrants.

     4.6 Purchaser  Review.  Purchaser  hereby  represents and warrants that the
Purchaser has carefully  examined the SEC Reports,  including the 1995 10-K, and
the Draft  1996  10-K,  and the  Financial  Statements  contained  therein.  The
Purchaser  acknowledges that the Company has made available to the Purchaser all
documents and information that it has requested  relating to the Company and has
provided answers to all of its questions  concerning the Company, the Shares and
the Warrants.  Nothing stated in the previous two sentences,  however,  shall be
deemed to affect the  representations and warranties of the Company contained in
this Agreement.

     4.7 Legend.  The  certificate or certificates  representing  the Securities
shall be subject to a legend restricting transfer under the Securities Act, such
legend to be substantially as follows:

          "THE SHARES  REPRESENTED  BY THIS  CERTIFICATE  HAVE BEEN ACQUIRED FOR
     INVESTMENT AND HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933.
     SUCH  SHARES  MAY  NOT BE  SOLD  OR  TRANSFERRED  IN THE  ABSENCE  OF  SUCH
     REGISTRATION OR AN EXEMPTION  THEREFROM UNDER SAID ACT WHICH, EXCEPT IN THE
     CASE OF AN EXEMPTION PURSUANT TO RULE 144 UNDER SAID ACT, IS CONFIRMED IN A
     LEGAL OPINION SATISFACTORY TO THE COMPANY."

The certificates shall also include any legends required by any applicable state
securities laws.

     The legend(s) endorsed on a stock certificate  pursuant to this Section 4.7
or on any certificate  representing  any of the Securities  shall be removed and
the Company  shall issue a  replacement  certificate  without such legend to the
holder of such certificate if the Securities represented by such certificate are
registered under the Securities Act or if such holder provides to the Company an
opinion of counsel to the effect that a public sale,  transfer or  assignment of
such Securities may be made without registration.


                                      E-25

<PAGE>



     4.8 Restrictions on Conversion of Shares.  Notwithstanding  anything to the
contrary  contained  herein,  no Shares may be  converted  by a holder of Shares
("Holder")  to the extent that,  after giving  effect to the  Conversion  Shares
issued pursuant to a Notice of Conversion,  the total number of shares of Common
Stock  deemed  beneficially  owned by such  Holder  (other than by virtue of the
ownership  of Shares or  Warrants or  ownership  of other  securities  that have
limitations  on a  Holder's  rights to  convert  or  exercise  similar  to those
limitations  set forth herein),  together with all shares of Common Stock deemed
beneficially  owned by Holder's  "affiliates"  (as defined in Rule 144 under the
Securities  Act) that would be aggregated for purposes of determining  whether a
group under Section 13(d) of the Exchange Act exists,  would exceed 4.99% of the
total issued and outstanding  shares of Common Stock,  provided that each Holder
shall have the right to waive this restriction, in whole or in part, immediately
in case of a pending Change in Control  Transaction  (as defined in Section 9.2)
and in any other case upon 61 days prior notice to the Company.  The delivery of
a Notice of  Conversion by any Holder shall be deemed a  representation  by such
Holder it is in  compliance  with this Section 4.8. A transferee of Shares shall
not be bound by this provision  unless it expressly  agrees to be so bound.  The
term  "deemed  beneficially  owned" as used in this  Section  4.8 shall  exclude
shares  that  might  otherwise  be  deemed  beneficially  owned by reason of the
convertibility of the Shares.

     Section 5.  Conditions  to the  Purchaser's  Obligation  to  Purchase.  The
Company  understands  that the Purchaser's  obligation to purchase the Shares is
conditioned upon:

          (a)  Acceptance  by  Purchaser of this  Agreement  for the sale of the
     Shares,  as evidenced by the execution of this  Agreement by its authorized
     officers;

          (b)  Delivery of the Shares and  Warrants  to the Escrow  Agent (or to
     Eilenberg & Zivian,  if the Purchaser  elects to wire funds directly to the
     Company);

          (c) The delivery at the Closing of a  certificate  from an  authorized
     officer of the Company certifying that all  representations  and warranties
     of the Company  are true and  correct as of the  Closing  Date (in the form
     annexed hereto as Exhibit B1); and

          (d) A filed Certificate of Designation.

     Section  6.   Conditions  to  Company's   Obligation  to  Sell.   Purchaser
understands  that the  Company's  obligation  to sell the Shares is  conditioned
upon:

          (a) The receipt and  acceptance  by the Company of this  Agreement  to
     issue  the  Shares as  evidenced  by  execution  of this  Agreement  by the
     President or any Vice President of the Company;

          (b)  Delivery  into escrow (or to the  Company) by  Purchaser  of good
     funds as payment in full for the purchase of the Shares; and

          (c) The delivery at the Closing of a  certificate  from an  authorized
     officer or representative of Purchaser  certifying that all representations
     and warranties of the

                                      E-26

<PAGE>



     Purchaser  are true and correct as of the Closing Date (in the form annexed
     hereto as Exhibit B2).

     Section 7. Registration of the Shares; Compliance with the Securities Act.

     7.1 Definitions. For the purpose of this Section 7:

          (a) the term  "Registration  Statement"  shall  mean any  registration
     statement  required to be filed by Section 7.2 below, and shall include any
     preliminary prospectus, final prospectus,  exhibit or amendment included in
     or relating to such registration statement; and

          (b) the term "untrue  statement" shall include any untrue statement or
     alleged untrue  statement,  or any omission or alleged omission to state in
     the Registration Statement a material fact required to be stated therein or
     necessary to make the statements therein, in the light of the circumstances
     under which they were made, not misleading.

     7.2 Registration Procedures and Expenses. The Company shall:

          (a) within  thirty (30) days after the Closing Date and in  sufficient
     time to have such registration  effective ninety (90) days from the Closing
     Date,  file with the SEC a registration  statement under the Securities Act
     on a form which is appropriate  to register the  Conversion  Shares and the
     Warrant Shares;

          (b) use its best efforts,  subject to receipt of necessary information
     from  the  Purchaser,  to  cause  such  Registration  Statement  to  become
     effective as promptly after filing as practicable;

          (c) prepare and file with the SEC such  amendments and  supplements to
     such Registration Statement and the prospectus used in connection therewith
     as may be necessary to keep such  Registration  Statement  effective  until
     termination of such obligation as provided in Section 7.9 below;

          (d)  furnish  to  the  Purchaser  with  respect  to the  Common  Stock
     registered on the Registration Statement (and to each underwriter,  if any,
     of such Common Stock) such number of copies of  prospectuses  in conformity
     with the requirements of the Securities Act and such other documents as the
     Purchaser may reasonably request, in order to facilitate the public sale or
     other  disposition  of all or any of the  Common  Stock  by the  Purchaser;
     provided,  however, that the obligation of the Company to deliver copies of
     prospectuses  to the  Purchaser  shall be  subject  to the  receipt  by the
     Company of reasonable assurances from the Purchaser that the Purchaser will
     comply with the  applicable  provisions of the  Securities  Act and of such
     other  securities  laws as may be applicable in connection  with any use of
     such prospectuses;

          (e) file such  documents  as may be required of the Company for normal
     securities law clearance for the resale of the Common Stock in which states
     of the United States

                                      E-27

<PAGE>



     as may be reasonably requested by the Purchaser;  provided,  however,  that
     the Company shall not be required in connection  with this paragraph (e) to
     qualify as a foreign corporation or execute a general consent to service of
     process in any jurisdiction;

          (f) bear all expenses in connection  with the procedures in paragraphs
     (a) through  (e) of this  Section  7.2 and the  registration  of the Common
     Stock on such  Registration  Statement and the satisfaction of the blue sky
     laws of such states,  including the  reasonable  fees and expenses of legal
     counsel to the Purchaser in connection with the procedures in paragraph (a)
     through (e) of this  Section 7.2,  other than  underwriting  discounts  and
     selling  commissions or expenses  required by law to be borne by Purchaser;
     and

          (g) in the event of the failure of Company to procure  registration of
     the Common Stock  underlying  the Shares  within  ninety (90) days from the
     Closing Date,  Company will pay Purchaser by wire  transfer,  as liquidated
     damages  for such  failure  and not as a penalty,  two (2%)  percent of the
     Liquidation  Preference (as defined below) of the Shares that have not been
     converted,  for each of the first two (2) months and three (3%) percent per
     month  thereafter that the Registration  Statement is not effective,  or in
     the event of a  Suspension  after such date.  If the Company does not remit
     the damages to the  Purchaser as set forth above,  the Company will pay the
     Purchaser  reasonable  costs of collection,  including  attorneys  fees, in
     addition  to the  liquidated  damages.  Such  payment  shall be made to the
     Purchaser  immediately if the  registration  of the Shares is not effected;
     provided,  however,  that the payment of such liquidated  damages shall not
     relieve the Company from its obligations to register the Shares pursuant to
     this Section.  The  registration  of the Shares  pursuant to this provision
     shall not affect or limit Purchaser's other rights or remedies as set forth
     in this Agreement.  In addition,  pursuant to Section 9.2, the restrictions
     on conversion set forth in Section 9.1 shall be eliminated, and Purchaser's
     right to convert the Shares  shall be  accelerated,  on the 104th day after
     the Closing Date if the  Registration  Statement  is not  effective by such
     day. The  "Liquidation  Preference" for a Share shall equal $1,000 (subject
     to  adjustments  for  Reclassifications),   plus  all  accrued  and  unpaid
     dividends (which shall accrue through the Conversion Date,  Redemption Date
     or the date liquidated damages are paid, as applicable) and any then unpaid
     liquidated  damages  (interest  on which  shall  accrue at a rate of 2% per
     month) arising under Sections 7.2(g), 9.2(c) or 9.6.

     7.3 Underwriter. The Company understands that the Purchaser disclaims being
an "underwriter" (as such term is defined under the Securities Act and the rules
and regulations promulgated thereunder (an "Underwriter")),  but Purchaser being
deemed an  Underwriter  shall not relieve the Company of any  obligation  it has
hereunder.

     7.4 Indemnification.

          (a) General  Indemnification.  Each of the  Company and the  Purchaser
     agrees to  indemnify  the other  and to hold the  other  harmless  from and
     against  any and all  losses,  damages,  liabilities,  costs  and  expenses
     (including reasonable attorneys' fees) which the other may sustain or incur
     in  connection   with  the  breach  by  the   indemnifying   party  of  any
     representation, warranty or covenant made by it in this Agreement.

          (b) Indemnification for Registration Statement.

                                      E-28

<PAGE>




               (i) By Company.  To the extent permitted by law, the Company will
          indemnify  and hold harmless each Holder,  the  directors,  if any, of
          such  Holder,  the  officers,  if any,  of such  Holder  who  sign the
          Registration Statement, each person, if any, who controls such Holder,
          any underwriter (as defined in the Securities Act) for the Holders and
          each person,  if any, who  controls  any such  underwriter  within the
          meaning of the Securities Act or the Exchange Act, against any losses,
          claims,  damages,  expenses or liabilities (joint or several) to which
          any of them may become subject under the Securities  Act, the Exchange
          Act or otherwise, insofar as such losses, claims, damages, expenses or
          liabilities   (or  actions  or  proceedings,   whether   commenced  or
          threatened,  in respect thereof) arise out of or are based upon any of
          the following  statements,  omissions or violations  (collectively,  a
          "Violation"):  (i) any untrue statement or alleged untrue statement of
          a material fact contained in the Registration  Statement including any
          preliminary  prospectus or final prospectus  contained  therein or any
          amendments  or  supplements  thereto,  (ii) the  omission  or  alleged
          omission  to state  therein  a  material  fact  required  to be stated
          therein,  or necessary to make the statements therein, in light of the
          circumstance  in which  they are  made,  not  misleading  or (iii) any
          violation or alleged  violation by the Company of the Securities  Act,
          the Exchange Act, any state  securities  law or any rule or regulation
          promulgated  under the  Securities  Act, the Exchange Act or any state
          securities  law; and the Company will  reimburse  the Holders and each
          such underwriter or controlling person,  promptly as such expenses are
          incurred,  for any legal or other expenses reasonably incurred by them
          in connection with  investigating  or defending any such loss,  claim,
          damage,  liability action or proceeding;  provided,  however, that the
          indemnity  agreement  contained in this Section 7.4(b) shall not apply
          to  amounts  paid in  settlement  of any  such  loss,  claim,  damage,
          liability or action if such settlement is effected without the consent
          of the Company,  which consent shall not be unreasonably withheld, nor
          shall the Company be liable in any such case for any such loss, claim,
          damage,  liability or action to the extent that it arises out of or is
          based upon a Violation which occurs in reliance upon and in conformity
          with written  information  furnished  expressly  for use in connection
          with such  registration  by the  Holders  or any such  underwriter  or
          controlling person, as the case may be. Such indemnity shall remain in
          full force and effect  regardless of any  investigation  made by or on
          behalf of the Holders or any such  underwriter or  controlling  person
          and shall survive the transfer of the Securities by Holders.

               (ii) By Holders.  To the extent  permitted  by law,  each Holder,
          severally  and not  jointly,  will  indemnify  and hold  harmless  the
          Company,  each of its directors,  each of its officers who have signed
          the  Registration  Statement,  each  person,  if any, who controls the
          Company  within the meaning of the Securities Act or the Exchange Act,
          any underwriter and any other stockholder  selling securities pursuant
          to the  Registration  Statement or any of its directors or officers or
          any  person who  controls  such  holder or  underwriter,  against  any
          losses, claims, damages or liabilities (joint or several) to which any
          of them may become subject, under the Securities Act, the Exchange Act
          or other federal state law, insofar as such losses, claims, damages or
          liabilities (or actions in respect  thereof) arise out of or are based
          upon  any  Violation,  in each  case to the  extent  (and  only to the
          extent) that such Violation  occurs in reliance upon and in conformity
          with written information furnished by such Holder expressly for use in
          connection with such registration,  and such Holder will reimburse any
          legal  or  other  expenses  reasonably  incurred  by  any of  them  in
          connection  with  investigating  or  defending  any such loss,  claim,
          damage,  liability or action;  provided,  however,  that the indemnity
          agreement contained in this subsection 6(b) shall not apply to amounts
          paid in settlement of such loss,

                                      E-29

<PAGE>



          claim,  damage,  liability  or action if such  settlement  is effected
          without  the  consent  of such  Holder,  which  consent  shall  not be
          unreasonably  withheld; and provided further, that the Holder shall be
          liable under this  paragraph  for only that amount of losses,  claims,
          damages and  liabilities  as does not exceed the net  proceeds to such
          Holder  as a result  of the sale of the  Securities  pursuant  to such
          registration.

               (c) Procedure for  Indemnification.  Promptly after receipt by an
          indemnified party under this Section 7.4 of notice of the commencement
          of any action  (including any governmental  action),  such indemnified
          party will,  if a claim in respect  thereof is to be made  against any
          indemnifying party under this Section 7.4, deliver to the indemnifying
          party a written notice of  commencement  thereof and the  indemnifying
          party shall have the right to  participate  in, and, to the extent the
          indemnifying  party so desires,  jointly  with any other  indemnifying
          party similarly noticed, to assume control of the defense thereof with
          counsel mutually satisfactory to the parties; provided,  however, that
          an  indemnified  party shall have the right to retain its own counsel,
          with the fees and expenses to be paid by the  indemnifying  party, if,
          in the  reasonable  opinion of  counsel  for the  indemnifying  party,
          representation  of such  indemnified  party by the counsel retained by
          the  indemnifying  party  would  be  inappropriate  due to  actual  or
          potential  differing  interests between such indemnified party and any
          other  party  represented  by such  counsel  in such  proceeding.  The
          failure to deliver written notice to the  indemnifying  party within a
          reasonable  time of the  commencement of any such action shall relieve
          such  indemnifying  party of any  liability to the  indemnified  party
          under this Section 7.4 only to the extent  prejudicial  to its ability
          to defend such action,  but the omission so to deliver  written notice
          to the indemnifying party will not relieve it of any liability that it
          may have to any  indemnified  party other than under this Section 7.4.
          The  indemnification  required  by this  Section  7.4 shall be made by
          periodic  payments  of the  amount  thereof  during  the course of the
          investigation or defense,  promptly as such expense,  loss,  damage or
          liability is incurred.

               (d)  Contribution.  To  the  extent  any  indemnification  by  an
          indemnifying  party is prohibited or limited by law, the  indemnifying
          party  agrees to make the  maximum  contribution  with  respect to any
          amounts for which it otherwise  would be liable under this Section 7.4
          to the extent  permitted  by law,  provided  that (i) no  contribution
          shall be made under the  circumstances  where the maker would not have
          been liable for indemnification under the fault standards set forth in
          this  Section  7.4,  (ii)  no  seller  of  the  Securities  guilty  of
          fraudulent  misrepresentation  (within the meaning of Section 11(f) of
          the Securities Act) shall be entitled to contribution  from any seller
          of  the   Securities   who  was   not   guilty   of  such   fraudulent
          misrepresentation   and  (iii)  contribution  by  any  seller  of  the
          Securities  shall be limited  in amount to the net amount of  proceeds
          received by such seller from the sale of such Securities.

     7.5  Information  Available.  So  long  as any  registration  statement  is
effective  covering the resale of the Conversion  Shares or Warrant Shares,  the
Company will furnish to Purchaser:

               (a) as soon as  possible  after  available,  one  copy of (i) its
          Annual  Report to  Stockholders  (which  Annual  Report shall  contain
          financial  statements  audited in accordance  with generally  accepted
          accounting  principles  in the United  States of America by a national
          firm  of  certified  public  accountants);  (ii)  if not  included  in
          substance in the Annual Report to

                                      E-30

<PAGE>



          Stockholders, its annual report on Form 10-K within 100 days after the
          end of each fiscal year of the  Company,  (iii) each of its  Quarterly
          Reports to Stockholders,  and its quarterly report on Form 10-Q within
          sixty (60) days,  and (iv) a full copy of the  registration  statement
          covering the Conversion  Shares and Warrant Shares (the foregoing,  in
          each case, excluding exhibits); and

               (b)  upon  the  reasonable  request  of  Purchaser,   such  other
          information that is generally available to the public.

     7.6 Rule 144  Reporting.  With a view to making  available  the benefits of
certain rules and  regulations  of the SEC which may at any time permit the sale
of  the  Conversion  Shares  and  the  Warrant  Shares  to  the  public  without
registration, the Company agrees to use its best efforts to:

          (a) make and keep  public  information  available,  as those terms are
     understood and defined in Rule 144 under the  Securities  Act, at all times
     after  the  effective  date on which the  Company  becomes  subject  to the
     reporting requirements of the Securities Act or the Exchange Act;

          (b) use its best  efforts to file with the SEC in a timely  manner all
     reports and other  documents  required of the Company under the  Securities
     Act and the Exchange Act;

          (c) to furnish to Purchaser forthwith upon request a written statement
     by the Company as to its compliance with the reporting requirements of said
     Rule 144, and of the  Securities  Act and the  Exchange  Act, a copy of the
     most  recent  annual or  quarterly  report of the  Company,  and such other
     reports  and  documents  of  the  Company  and  other  information  in  the
     possession  of or  reasonably  obtainable  by the Company as Purchaser  may
     reasonably  request in availing itself of any rule or regulation of the SEC
     allowing  Purchaser to sell any such  Conversion  Shares or Warrant  Shares
     without registration.

     7.7  Temporary  Cessation of Offers and Sales by  Purchaser.  The Purchaser
acknowledges  that  there may  occasionally  be times  when the  Company  may be
required to suspend the use of the prospectus  forming part of the  Registration
Statement (a  "Suspension")  until such time as an amendment to the Registration
Statement  has  been  filed  by  the  Company  and  declared  effective  by  the
Commission,  until the prospectus is  supplemented or amended to comply with the
Securities  Act,  or until  such time as the  Company  has filed an  appropriate
report with the  Commission  pursuant to the Exchange Act. The Company agrees to
file any necessary  amendments,  supplements  and reports as soon as practicable
under the  circumstances.  The Company agrees to use its best efforts to cause a
Suspension  to be lifted  within 10 business  days during  which time  Purchaser
agrees  that it will  not sell any  shares  of  Common  Stock  pursuant  to such
prospectus.

     7.8  Transfer  of   Conversion   Shares  or  Warrant   Shares  Stock  After
Registration.  Purchaser  hereby covenants with the Company not to make any sale
of the Conversion  Shares or Warrant Shares except either (i) in accordance with
the Registration Statement, in which case Purchaser covenants to comply with the
requirement of delivering a current prospectus, (ii) in

                                      E-31

<PAGE>



accordance with Rule 144, in which case Purchaser  covenants to comply with Rule
144, or (iii) as otherwise permitted by applicable law.

     7.9 Termination of Obligations.  The obligations of the Company pursuant to
Sections 7.2, 7.3 and 7.6 hereof shall cease and  terminate  upon the earlier to
occur of (i) such time as all of the  Conversion  Shares or Warrant  Shares have
been  re-sold,  or (ii) such  time as all of the  Common  Stock  may be  re-sold
pursuant to Rule 144(k) under the Securities Act.

     Section 8. Legal Fees and  Expenses.  Each of the parties shall pay its own
fees and expenses (including the fees of any attorneys, accountants,  appraisers
or others  engaged by such  party) in  connection  with this  Agreement  and the
transactions contemplated hereby.

     Section 9. Conversion; Acceleration; Liquidated Damages.

     9.1 Restrictions on Conversion. Conversion of the Shares may be made at the
Conversion Price as follows:

          0 - 90 days      None
          91 - 180 days    Up to 40% of the aggregate Liquidation Preference
                           for the Shares (the "Aggregate Liquidation
                           Preference")
          181 - 270 days   Up to 80% of the Aggregate Liquidation Preference
          after 270 days   100% of the Aggregate Liquidation Preference
     
     9.2 Acceleration of Conversion.

          (a) If after ninety (90) days from the Closing  Date,  the closing bid
     price on Nasdaq of the  Company's  Common Stock  exceeds 200% of the Nasdaq
     closing bid price on the Closing Date for a period of five (5)  consecutive
     days, Purchaser may convert an additional 25% of the Aggregate  Liquidation
     Preference.  If after ninety (90) days from the Closing  Date,  the closing
     bid price on Nasdaq  of the  Company's  Common  Stock  exceeds  300% of the
     closing bid price on the Closing  Date,  the  Purchaser may convert 100% of
     the  Aggregate  Liquidation  Preference  without any  remaining  conversion
     restrictions.

          (b)  Purchaser  may also  convert  100% of its  Aggregate  Liquidation
     Preference  commencing  on the date  which is two  weeks  after  any of the
     following  events  ("Acceleration  Events"),  except that there shall be no
     such two week  delay in the event of a Change in Control  Transaction  or a
     Going Private Transaction (both as defined herein):

               (i) the date the  Company's  Common  Stock is  delisted  from the
          Nasdaq  Small Cap  Market  and is not  otherwise  listed on a national
          securities exchange or the Nasdaq National Market (a "Delisting");

               (ii) the date the Company (I) sells or  otherwise  conveys all or
          substantially  all of its  assets or (II)  effects a  transaction  (by
          merger or otherwise) in which more than 50% of the voting power of the
          Company is disposed of, directly or indirectly, or if within

                                      E-32

<PAGE>



          any 12 month  period there is a change of more than 50% of the members
          of the Company's Board of Directors, or if any other person, entity or
          group (as defined in Section  13(d) of the Exchange Act) and/or any of
          their affiliates or associates acquires in excess of 50% of the Common
          Stock (collectively, a "Change in Control Transaction");

               (iii) the date the Company completes any transaction or series of
          transactions the result of which would cause the Common Stock to cease
          being publicly traded,  included without  limitation  pursuant to Rule
          13e-3  promulgated  under the Exchange Act (other than a  transaction,
          that is not a Change in Control Transaction, in which the Common Stock
          is exchanged for other publicly traded  securities)  (a"Going  Private
          Transaction");

               (iv) the date a Suspension  has occurred and is continuing or the
          date  that  is the  15th  day in the  aggregate  that  more  than  one
          Suspension has occurred  since the effective date of the  Registration
          Statement (a "Cumulative Suspension");

               (v) the Registration Statement is not effective 90 days after the
          Closing Date;

               (vi) the date the number of  authorized  but  unissued  shares of
          Common  Stock are not  sufficient  to  effect  the  conversion  of all
          outstanding  Shares then eligible for  conversion  (whether or not the
          Holders  have duly  delivered  Notices of  Conversion)  ("Insufficient
          Authorized Stock"); or

               (vii) the date the Company receives a deficiency  notice from the
          U.S. Food and Drug Administration (the "FDA") withdrawing  approval of
          all  filings  by  the  FDA  of  the  Company's  New  Drug  Application
          submissions for products utilizing loteprednol etabonate.

          (c) Notice of Conversion. Conversion of the Shares to Common Stock may
     be exercised in whole or in part by Purchaser  telecopying  an executed and
     completed Notice of Conversion (in the form annexed hereto as Exhibit C) to
     counsel for the Company,  with a copy to the Company,  and  delivering  the
     original Notice of Conversion and the certificate  representing  the Shares
     to counsel by hand or by express  courier within three (3) business days of
     exercise.  Each date on which a Notice of  Conversion  is telecopied to and
     received by the Company in accordance  with the provisions  hereof shall be
     deemed a  Conversion  Date.  The Company  will  transmit  the  certificates
     representing  the Common Stock issuable upon  conversion of all or any part
     of the Shares (together with any  certificates  for replacement  Shares not
     previously converted but included in the original certificate presented for
     conversion) to the Purchaser via express  courier within three (3) business
     days after  counsel for the Company has  received  the  original  Notice of
     Conversion and the certificate  representing the Shares being so converted.
     The Notice of Conversion and  certificate  representing  the portion of the
     Shares converted shall be delivered as follows:

                           To counsel:

                           Eilenberg & Zivian

                                      E-33

<PAGE>



                           666 Third Avenue, 30th Fl.
                           New York, NY  10017
                           (Tele) (212) 986-2468
                           (Fax) (212) 986-2399

                           To the Company:

                           Pharmos Corporation
                           2 Innovation Drive
                           Alachua, FL  32615
                           Attn:  President
                           (Tele) (904) 462-1210
                           (Fax) (904) 462-5401

or to such other  person at such other place as the Company  shall  designate to
the Purchaser in writing.

     In the event that the Shares are not  converted  within  three (3) business
days of the Conversion Date, the Company shall be liable to Purchaser for actual
damages  incurred from the fourth  business day following  the  Conversion  Date
through the ninth  business day following the  Conversion  Date for such failure
(provided  that  Purchaser has delivered the original valid Notice of Conversion
and the original  certificate(s)  representing the Shares to be converted, or an
affidavit  and   indemnity   agreement  as  to  lost   certificates   reasonably
satisfactory  to the Company).  In the event the Shares are not converted by the
tenth (10th)  business day following the Conversion  Date, the Company shall pay
to the Purchaser,  by wire transfer,  as liquidated damages for such failure and
not as a  penalty,  an amount in cash equal to one (1%)  percent  per day of the
Liquidation  Preference for the Shares to be converted  which shall run from the
tenth (10th) business day following the Conversion Date; provided, however, that
actual damages and liquidated  damages for a failure to deliver  certificates of
Common Stock shall be determined in accordance  with Section 9.6, if both of the
following  conditions  are satisfied by the Company:  (i) the failure to deliver
certificates of Common Stock is the result of a lack of available authorized but
unissued shares of Common Stock and (ii) the Company commences,  within ten (10)
business days after the initial  Conversion  Date,  and uses its best efforts to
obtain  stockholder  approval to amend its Articles of Incorporation to increase
the  number of  authorized  shares of Common  Stock by an amount  sufficient  to
permit conversion of all Shares then outstanding at the Hypothetical  Conversion
Price (as hereinafter defined) then in effect.

     9.3  Restrictions on Sales by Purchaser.  Purchaser  agrees that neither it
nor any  person  or  entity  for whom it is  holding  Shares  will  directly  or
indirectly sell any of the Common Stock (including short sales) during three (3)
business days prior to a conversion by Purchaser.

     9.4 Mandatory  Conversion.  The Shares are subject to mandatory  conversion
after  three (3) years from the  Closing  Date,  at which  time all Shares  will
automatically be converted at the Conversion  Price, upon the terms set forth in
this  section.  Such three year  period  will be  extended by the number of days
during such period that (i) the Company's

                                      E-34

<PAGE>



Common Stock has been Delisted  and/or (ii) a Suspension  has been in effect and
by the  number  of days  after  the  90th day  from  the  date  hereof  that the
Registration  Statement was not declared effective.  Any particular day in which
more than one of the foregoing  condition events shall have been in effect shall
only be counted  once in  determining  the number of days by which to extend the
three  year  period  prior  to  mandatory  conversion.  In  addition,  mandatory
conversion  shall not occur for so long as certain  default events  specified in
Section 5(e) of the Certificate of Designation are continuing.

     9.5 Reservation of Common Stock Issuable Upon Conversion. The Company shall
at all times  reserve and keep  available  out of its  authorized  but  unissued
shares of Common Stock,  such number of its shares of Common Stock as shall from
time to time be  sufficient  to effect the  conversion  of all then  outstanding
Shares and Warrants,  the  sufficiency of which shall be determined (in the case
of the Shares) by using a Conversion Price (the "Hypothetical Conversion Price")
derived from a  hypothetical  closing market price that is 75% of either (i) the
actual  Average  Closing  Price on the Closing  Date or (ii) the actual  Average
Closing  Price  from time to time,  whichever  is lower,  and in the case of the
Warrants, by the exercise price thereof. The Company hereby covenants and agrees
that if at any time the  Hypothetical  Conversion  Price  falls to a level  that
would  not  enable  all  outstanding  Shares  to  be  fully  converted  and  the
outstanding  Warrants to be fully  exercised,  the Company will promptly use its
best efforts to obtain stockholder approval, within 90 days thereafter, to amend
its Articles of  Incorporation  to increase the number of  authorized  shares of
Common Stock by an amount sufficient to permit the conversion of all Shares then
outstanding at the Hypothetical Conversion Price then in effect.

     9.6  Liquidated  Damages.  In  the  event  of  a  Delisting,  a  Cumulative
Suspension or Insufficient Authorized Stock (each a "Damage Event"), the Company
will  pay to  Purchaser  (and  to all  other  holders  of the  Shares),  by wire
transfer,  as liquidated damages for such  nonavailability and not as a penalty,
an amount in cash equal to 2% per month of the  Liquidation  Preference  of only
those Shares then eligible for  conversion,  without  regard to Section 4.8, for
the first two months after the  occurrence of a Damage  Event,  and 3% per month
for each month thereafter. Similar liquidated damages shall be paid with respect
to any Shares not initially  eligible for conversion when the Damage Event first
occurred but which subsequently  become eligible for conversion,  without regard
to Section 4.8,  commencing in the first month that such Shares become  eligible
for such conversion.  Such liquidated damages shall continue to accrue and shall
be payable  until the Damage  Event has been cured,  and, if not paid,  interest
thereon  shall accrue at a rate of 2% per month.  At the  Purchaser's  election,
such liquidated  damages may be paid in cash or may be added to the principal of
the Shares for subsequent conversion purposes. Notwithstanding the foregoing, in
the case of a Delisting,  after six months from the date of such Delisting,  the
Company  shall have the option to either (i) force  Purchaser  to as promptly as
possible  convert (in  increments  of no less than  $50,000)  all or part of its
Shares,  subject  to  Purchaser  being  able to sell the  underlying  Conversion
Shares,  and  simultaneously  sell such Conversion  Shares (where the conversion
price therefor shall not be the Conversion  Price but instead shall equal 83% of
the  Purchaser's  sale  price of the  Conversion  Shares,  for the  first 25% of
Purchaser's Aggregate Liquidated  Preference  converted,  and 80% of Purchaser's
sale price of the  Conversion  Shares for the  remainder,  all as  determined by
Purchaser's  actual  trading  records (to be  provided  to the  Company) or (ii)
redeem Purchaser's Shares pursuant to Section

                                      E-35

<PAGE>



10 below.  In no event may the  Company  force  Purchaser  to convert  less than
$50,000 of Shares at any one time.

     Section 10. Redemption By Company.

     10.1 Company's  Right to Redeem.  The Company shall have the right,  in its
sole  discretion,  to redeem  in whole or in part the  Shares  when the  average
Nasdaq closing bid price is more than 200% above the Nasdaq closing price on the
Closing  Date for the five (5)  consecutive  days prior to the date the  Company
makes such  election to redeem.  If the Company  elects to redeem some,  but not
all,  of the  Shares,  the  Company  shall  redeem the Shares pro rata among the
Holders of all Shares then outstanding.  The date of the Company's redemption of
Shares shall be referred to as the "Redemption Date."

     10.2 Redemption Price. The redemption price per Share shall equal:

                             Liquidation Preference
                                       80%

     10.3 Mechanics of Redemption;  Purchaser's  Conversion  Rights. The Company
shall  effect each such  redemption  by giving  notice of its election to redeem
("Redemption Notice"),  which shall be irrevocable,  by facsimile, by 5 P.M. New
York City time the next business day following its election to redeem Shares and
shall provide a copy of such redemption notice by overnight or 2-day courier, to
Purchaser,  all other Holders of Shares and the Company's  Transfer Agent.  Such
redemption notice shall indicate (i) whether the Company will redeem all or part
of the Shares,  (ii) the applicable  redemption price and (iii) that the average
Nasdaq  closing bid price has exceeded by 200% the Nasdaq  closing  price on the
Closing  Date for the five (5)  consecutive  days prior to the date the  Company
elects to redeem Shares.  Notwithstanding  the foregoing,  Purchaser  shall have
five business days following  receipt of the Redemption  Notice from the Company
to elect, in its sole discretion, to convert all or part of the Shares otherwise
being  redeemed.  Such  conversion  shall be  effected  in  accordance  with the
Certificate  of  Designation,  and if an  appropriate  Notice of  Conversion  is
delivered to the Company in a timely  manner,  such Shares shall be deemed to be
converted and not redeemed.


     10.4 Company Must Have  Immediately  Available Funds or Credit  Facilities.
The Company  shall not be entitled to send any  Redemption  Notice and begin the
redemption procedure hereunder unless it has:

          (i) the full amount of the  redemption  price in cash,  available in a
     demand  or  other  immediately  available  account  in a  bank  or  similar
     financial institution; or

          (ii) immediately  available credit  facilities,  in the full amount of
     the redemption price with a bank or similar financial institution; or


                                      E-36

<PAGE>



          (iv) a  combination  of the  items  set  forth in (i) and (ii)  above,
     aggregating the full amount of the redemption price.

     10.5 Payment of  Redemption  Price.  Upon  receipt of a  Redemption  Notice
Purchaser  shall send its Shares  being  redeemed to the Company or its Transfer
Agent,  and the Company shall pay the applicable  redemption  price within three
(3) business  days of receipt of the Shares.  The Company shall not be obligated
to deliver the  redemption  price unless the Shares so redeemed are delivered to
the Company or its  Transfer  Agent,  or, in the event one or more  certificates
have been lost,  stolen,  mutilated  or  destroyed,  Purchaser  delivers  to the
Company a lost certificate  affidavit and indemnification  agreement  reasonably
satisfactory to Company and the Transfer Agent.

     10.6 Blackout Period.  Notwithstanding  the foregoing,  the Company may not
either send out a  redemption  notice or effect a  redemption  during a Blackout
Period  (defined as a period  during which the  Company's  officers or directors
would not be entitled to buy or sell stock  because of their holding of material
non-public information).  In the event the Company initiates a redemption during
a  Blackout  Period  without  having  first  made  public  material   non-public
information, the Company shall disclose the non-public information that resulted
in the Blackout  Period,  and no redemption  shall be effected until at least 10
days after the  Company  shall have given the  Holder  written  notice  that the
Blackout Period has been lifted.

     Section  11.   Notices.   All   notices,   requests,   consents  and  other
communications  hereunder  shall be in  writing,  shall be mailed by first class
registered or certified airmail,  postage prepaid, or shall be sent by overnight
courier or by facsimile, and shall be deemed given when received:

                            (a) if to the Company, to

                                Pharmos Corporation
                                2 Innovation Drive
                                Alachua, FL  32615
                                (Tele) 904-462-1210
                                (Fax) 904-462-5401

                                copy to:

                                Adam D. Eilenberg, Esq.
                                Eilenberg & Zivian
                                666 Third Avenue, 30th Fl.
                                New York, NY  10017
                                (Tele) (212) 986-2468
                                (Fax) (212) 986-2399

or to such other  person at such other place as the Company  shall  designate to
the Purchaser in writing;


                                      E-37

<PAGE>



                           (b) if to the Purchaser, to

                              --------------------------

                              --------------------------

                              --------------------------

                               copy to:

                              --------------------------

                              --------------------------

                              --------------------------

or at such other address or addresses as may have been  furnished to the Company
in writing; or

     (c) if to any transferee or transferees of a Purchaser,  at such address or
addresses  as  shall  have  been  furnished  to the  Company  at the time of the
transfer or  transfers,  or at such other  address or addresses as may have been
furnished by such transferee or transferees to the Company in writing.

- -     Section 12. Miscellaneous.

     12.1 Entire  Agreement.  This Agreement  embodies the entire  agreement and
understanding  between the parties  hereto  with  respect to the subject  matter
hereof and  supersedes all prior oral or written  agreements and  understandings
relating to the subject matter hereof. No statement,  representation,  warranty,
covenant or  agreement  or any kind not  expressly  set forth in this  Agreement
shall affect, or be used to interpret, change or restrict, the express terms and
provisions of this Agreement.

     12.2  Amendments.  This  Agreement  may not be modified  or amended  except
pursuant to an instrument in writing signed by the Company and by Purchaser.

     12.3 Headings.  The headings of the various sections of this Agreement have
been inserted for  convenience  of reference  only and shall not be deemed to be
part of this Agreement.

     12.4 Severability. In case any provision contained in this Agreement should
be invalid, illegal or unenforceable in any respect, the validity,  legality and
enforceability of the remaining provisions contained herein shall not in any way
be affected or impaired thereby.

     12.5  Governing  Law/Jurisdiction.  This  Agreement  will be construed  and
enforced in  accordance  with and governed by the laws of the State of New York,
except for matters  arising  under the  Securities  Act,  without  reference  to
principles of conflicts of law. Each

                                      E-38

<PAGE>


of the parties  consents to the  jurisdiction of the courts of or located in the
State of New York,  specifically  the  Southern  District of New York and/or the
Supreme  Court of the State of New York in connection  with any dispute  arising
under this Agreement and hereby waives,  to the maximum extent permitted by law,
any objection,  including any objection  based on forum non  conveniens,  to the
bringing of any such proceeding in such jurisdictions.  Each party hereby agrees
that if another party to this Agreement  obtains a judgment against it in such a
proceeding,  the party which  obtained such judgment may enforce same by summary
judgment in the courts of any country having jurisdiction over the party against
whom such  judgment  was  obtained,  and each party  hereby  waives any defenses
available  to it  under  local  law  and  agrees  to the  enforcement  of such a
judgment.  In  addition,  the  parties  agree that the party  against  whom such
judgment  was  obtained  will pay the  legal  fees of the party  obtaining  such
judgment.  Each party to this Agreement  irrevocably  consents to the service of
process in any such proceeding by the mailing of copies thereof by registered or
certified mail, postage prepaid,  to such party at its address set forth herein.
Nothing herein shall affect the right of any party to serve process in any other
manner permitted by law.

     12.6  Recovery  of  Attorney's  Fees.  Should any party  bring an action to
enforce the terms of this Agreement  then, if Purchaser  prevails in such action
it should be entitled to recovery of its attorney's  fees from the Company,  and
if the  Company  prevails in such action it shall be entitled to recovery of its
attorney's fees from the Purchaser.

     12.7 Fees.  Notwithstanding  Section 12.6,  the Company  acknowledges  that
Purchaser  shall have no  responsibility  for the  payment of any of its fees in
connection with this offering.

     12.8 Counterparts/Facsimile.  This Agreement may be executed in two or more
counterparts, each of which shall constitute an original, but all of which, when
taken together, shall constitute but one instrument,  and shall become effective
when  one or more  counterparts  have  been  signed  by each  party  hereto  and
delivered to the other party. In lieu of the original, a facsimile  transmission
or copy of the original shall be as effective and enforceable as the original.

     12.9  Publicity.  The  Purchaser  shall not issue  any  press  releases  or
otherwise  make  any  public   statement   with  respect  to  the   transactions
contemplated by this Agreement without the prior written consent of the Company,
except as may be required by applicable law or regulation.

     12.10 Survival.  The representations and warranties in this Agreement shall
survive Closing.


                                      E-39

<PAGE>


     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
signed by their duly  authorized  representatives  the day and year first  above
written.


                                                     PHARMOS CORPORATION


                                                     By
                                                       -------------------------
                                                         Officer

                                                     _____________, PURCHASER


                                                     By
                                                       -------------------------
                                                         Officer


                                      E-40

<PAGE>



                                                                       EXHIBIT A

                           CERTIFICATE OF DESIGNATION

                                      E-41

<PAGE>


               CERTIFICATE OF DESIGNATION, RIGHTS, PREFERENCES AND
                     PRIVILEGES OF SERIES B PREFERRED STOCK
                                       OF
                               PHARMOS CORPORATION

                              A Nevada Corporation

     Pursuant to Nevada  Revised  Statutes,  Section  78.1955,  the  undersigned
hereby certifies as follows:

          1.  That  he  is  the  President  and  Acting   Secretary  of  Pharmos
     Corporation, a Nevada corporation (the "Corporation"); and

          2. That,  pursuant to the  authority  conferred  on the  Corporation's
     Board  of  Directors  (the  "Board")  by  ARTICLE  IV,  Section  2  of  the
     Corporation's  Restated Articles of Incorporation,  the Board, at a special
     meeting  of the  Board  held on March 27,  1997,  (a)  adopted  resolutions
     providing for the issuance of shares of the  Corporation's  Preferred Stock
     to be  designated  as shares of "Series B  Preferred  Stock" and fixing the
     number  of such  shares  of  Series  B  Preferred  Stock  and  the  powers,
     designations, privileges, preferences, limitations, restrictions, price and
     relative rights of such Series B Preferred Stock as more fully set forth in
     the Statement of Designation,  Rights, Preferences and Privileges of Series
     B  Preferred  Stock of the  Corporation  attached  hereto and  incorporated
     herein by this reference; and (b) authorized the filing of this Certificate
     with the Nevada Secretary of State.

     IN WITNESS  WHEREOF,  the  undersigned  have executed this  Certificate  of
Designation,  Rights,  Preferences and Privileges of Series B Preferred Stock of
PHARMOS CORPORATION on this 27th day of March, 1997.



                                                       /s/ Gad Riesenfeld
                                                       ------------------------
                                                       Gad Riesenfeld
                                                       President



                                                       /s/ Gad Riesenfeld
                                                       ------------------------
                                                       Gad Riesenfeld
                                                       Acting Secretary





                                      E-42

<PAGE>




STATE OF Florida     )
                         )       ss.
COUNTY OF Alachua )

     On this 27th day of March 1997, personally appeared before the undersigned,
a Notary Public, as the President and Acting Secretary of PHARMOS CORPORATION, a
Nevada  corporation,  known to me to be the person described in and who executed
the foregoing  instrument  freely and  voluntarily and for the uses and purposes
mentioned.

     IN WITNESS  WHEREOF,  I have  hereunto  set my hand and affixed my official
seal on the day and year in this certificate first written above.


                                                     /s/ Sandra V. Burgess
                                                     ---------------------------
                                                        NOTARY PUBLIC



                                      E-43

<PAGE>



                STATEMENT OF DESIGNATION, RIGHTS, PREFERENCES AND
                     PRIVILEGES OF SERIES B PREFERRED STOCK
                                       OF
                              PHARMOS CORPORATION,
                              a Nevada Corporation

     The designation,  rights,  preferences and privileges of, and other matters
relating to, the Company's  Series B Preferred Stock or the holders  ("Holders")
of record thereof are as follows:

     Section 1. Designation and Amount. The series of Preferred Stock designated
and known as the "Series B Preferred  Stock"  shall have a par value of $.03 per
share and the number of shares  constituting  the Series B Preferred Stock shall
be 6,000.  The Series B Preferred  Stock shall have a stated value of $1,000 per
share, with a 5% per annum dividend as set forth herein.

     Section 2. Rank. The Series B Preferred  Stock shall rank: (i) prior to all
of the Company's Common Stock, par value $.03 per share ("Common  Stock");  (ii)
pari passu with all the Company's  Series A Preferred Stock ("Series A Preferred
Stock");  and (iii) prior to any class or series of capital stock of the Company
hereafter  created (unless it specifically,  by its terms,  ranks on parity with
the Series B Preferred  Stock),  in each case as to distributions of assets upon
liquidation,  dissolution  or winding up of the  Company,  whether  voluntary or
involuntary   (all  such   distributions   being  referred  to  collectively  as
"Distributions").

     Section 3. Dividends. The Series B Preferred Stock will bear a 5% per annum
cumulative  dividend,  payable at the time of conversion in cash or Common Stock
at the Conversion Price (as defined herein), at the Company's option.

     Section 4. Liquidation Preference.

          (a) In the event of any liquidation,  dissolution or winding up of the
     Company, either voluntary or involuntary, the Holders of Series B Preferred
     Stock,  pari passu with the Holders of Series A Preferred  Stock,  shall be
     entitled  to receive an amount per share equal to the sum of (i) $1,000 for
     each outstanding  share of Series B Preferred Stock (subject to adjustments
     for  Reclassifications (as defined in herein), plus (ii) an amount equal to
     all accrued and unpaid dividends (which shall accrue through the Conversion
     Date,  Redemption  Date  (both as defined  herein)  or the date  liquidated
     damages are paid, as  applicable)  and any then unpaid  liquidated  damages
     (interest  on which shall accrue at a rate of 2% per month)  arising  under
     Sections 5(c) or (g) (the "Liquidation Preference"). If upon the occurrence
     of such event,  the assets and funds available to be distributed  among the
     Holders of the Series B Preferred Stock shall be insufficient to permit the
     payment  to such  Holders  of the  full  preferential  amounts  due to such
     Holders,  then the entire assets and funds of the Company legally available
     for distribution shall be distributed among the Holders of the Series B and
     Series A Preferred Stock on a pro rata basis.

          (b) A sale,  conveyance or disposition of all or substantially  all of
     the assets of the Company shall be deemed to be a liquidation,  dissolution
     or winding up within the meaning of this Section 4; provided  further that,
     a consolidation, merger, acquisition, or other business

                                      E-44

<PAGE>



     combination  of the Company with or into any other  Company or Companies or
     the  effectuation  by the  Company  of a  transaction  or series of related
     transactions  in which more than 50% of the voting  power of the Company is
     disposed of shall not be treated as a  liquidation,  dissolution or winding
     up within the  meaning  of this  Section  4, but  instead  shall be treated
     pursuant to Section 5(i)(ii) hereof.

     Section 5. Conversion.  The record Holders of this Series B Preferred Stock
shall have conversion rights as follows (the "Conversion Rights"):

          (a) Right to Convert.  Each record Holder of Series B Preferred  Stock
     shall be  entitled  to  convert  shares of Series B  Preferred  Stock (at a
     minimum of twenty (20) shares per  conversion) as follows:  (1) up to forty
     percent (40%) of the  aggregate  Liquidation  Preference  for the shares of
     Series B Preferred  Stock held by such Holder (the  "Aggregate  Liquidation
     Preference")  at any  time  beginning  91 days  following  the  date of the
     closing of the sale of shares of Series B  Preferred  Stock to such  Holder
     (the "Closing Date"), and at anytime  thereafter;  (2) up to eighty percent
     (80%) of the Aggregate  Liquidation  Preference  at any time  beginning 181
     days following the Closing Date, and at anytime thereafter; and (3) 100% of
     the  Aggregate  Liquidation  Preference  at any  time  beginning  271  days
     following the Closing Date, and at anytime thereafter,  into that number of
     fully-paid  and  non-assessable  shares  of  Common  Stock  of the  Company
     calculated  in  accordance  with the  following  formula  (the  "Conversion
     Rate"):

     Number  of  shares  issued  upon  conversion  of one (1)  share of Series B
Preferred Stock =

                             Liquidation Preference
                             ----------------------
                                Conversion Price

where, "Conversion Price" means (i) an amount equal to a seventeen (17%) percent
discount  from the  average  closing  price of the Common  Stock as  reported by
Nasdaq for the  previous  three (3)  business  days ending on the day before the
Conversion  Date (the  "Average  Closing  Price")  for the first 25% of Holder's
Aggregate Liquidation Preference converted;  or (ii) an amount equal to a twenty
(20%) percent  discount from the Average Closing Price for amounts  converted in
excess of 25% of Holder's Aggregate  Liquidation  Preference.  The closing price
referred to above shall be the last reported sales price, or if no reported sale
takes place on such day, the average of the closing bid and asked prices. If the
Common  Stock is not traded on Nasdaq,  the Average  Closing  Price shall be the
average  closing  price  (and if not  available,  the  mean of the  high and low
prices)  of the Common  Stock on the  over-the-counter-market  or the  principal
national  securities  exchange or the National Market System on which the Common
Stock is traded  for the  previous  three (3)  business  days  ending on the day
before the Conversion Date.

         The Conversion Price shall be equitably  adjusted  accordingly on a pro
rata basis in the event of the happening of certain events that would affect the
Common Stock or the Series B Preferred Stock's value including,  but not limited
to,  forward and reverse  splits,  dividend  payments on shares,  subdivision of
shares, combinations,  reclassifications,  issuance of rights, warrants, options
or any other event described in Section 5(i) (collectively "Reclassifications").

                                      E-45

<PAGE>



An adjustment made pursuant to this section shall become  effective  immediately
after the effective  date of such event  retroactive to the record date, if any,
for such an event.

         (b) Acceleration.

          (i) If after ninety (90) days from the Closing  Date,  the closing bid
     price on Nasdaq of the  Company's  Common Stock  exceeds 200% of the Nasdaq
     closing bid price on the Closing Date for a period of five (5)  consecutive
     days, each Holder may convert an additional 25% of such Holder's  Aggregate
     Liquidation  Preference.  If after ninety (90) days from the Closing  Date,
     the closing bid price on Nasdaq of the Company's  Common Stock exceeds 300%
     of the closing bid price on the Closing Date,  each Holder may convert 100%
     of its Aggregate  Liquidation  Preference without any remaining  conversion
     restrictions.

          (ii) Each Holder may also  convert 100% of its  Aggregate  Liquidation
     Preference  commencing  on the date  which is two  weeks  after  any of the
     following  events  ("Acceleration  Events"),  except that there shall be no
     such two week  delay in the event of a Change in Control  Transaction  or a
     Going Private Transaction (both as defined herein):

               (A) the date the  Company's  Common  Stock is  delisted  from the
          Nasdaq  Small Cap  Market  and is not  otherwise  listed on a national
          securities exchange or the Nasdaq National Market (a "Delisting");

               (B) the date the  Company (I) sells or  otherwise  conveys all or
          substantially  all of its  assets or (II)  effects a  transaction  (by
          merger or otherwise) in which more than 50% of the voting power of the
          Company is disposed of,  directly or  indirectly,  or if within any 12
          month  period there is a change of more than 50% of the members of the
          Company's  Board of  Directors,  or if any affiliate of the Company or
          any other person,  entity or group (as defined in Section 13(d) of the
          Exchange   Act)  acquires  in  excess  of  50%  of  the  Common  Stock
          (collectively, a "Change in Control Transaction");

               (C) the date the Company  completes any  transaction or series of
          transactions the result of which would cause the Common Stock to cease
          being publicly traded,  included without  limitation  pursuant to Rule
          13e-3  promulgated  under  the  Securities  Exchange  Act of 1934,  as
          amended (the "Exchange Act") (other than a transaction,  that is not a
          Change in Control Transaction,  in which the Common Stock is exchanged
          for other publicly traded securities) (a"Going Private Transaction");

               (D) the date of a suspension (a  "Suspension")  of the use of the
          prospectus   forming   part  of  the   registration   statement   (the
          "Registration  Statement")  filed under the Securities Act of 1933, as
          amended (the "Securities  Act") registering the shares of Common Stock
          issuable  upon the  conversion  of the  Series B  Preferred  Stock has
          occurred  and is  continuing  or the date  that is the 15th day in the
          aggregate  that  more  than one  Suspension  has  occurred  since  the
          effective   date  of  the   Registration   Statement  (a   "Cumulative
          Suspension");

               (E) the Registration Statement is not effective 90 days after the
          Closing Date;

                                      E-46

<PAGE>


               (F) the date the  number of  authorized  but  unissued  shares of
          Common  Stock are not  sufficient  to  effect  the  conversion  of all
          outstanding  shares of Series B  Preferred  Stock  then  eligible  for
          conversion  (whether or not the Holders have duly delivered Notices of
          Conversion) ("Insufficient Authorized Stock"); or

               (G) the date the Company  receives a  deficiency  notice from the
          U.S. Food and Drug Administration (the "FDA") withdrawing  approval of
          all  filings  by  the  FDA  of  the  Company's  New  Drug  Application
          submissions for products utilizing loteprednol etabonate.

          (c)  Mechanics  of  Conversion.  Conversion  of the Series B Preferred
     Stock to  Common  Stock  may be  exercised  in  whole or in part by  Holder
     telecopying  an executed and  completed  notice of  conversion  ("Notice of
     Conversion")  (in the form annexed  hereto as Exhibit A) to counsel for the
     Company,  with a copy to the Company, and delivering the original Notice of
     Conversion  and  the  certificate  representing  the  shares  of  Series  B
     Preferred  Stock to counsel by hand or by express  courier within three (3)
     business  days of exercise.  Each date on which a Notice of  Conversion  is
     telecopied  to and received by counsel for the Company in  accordance  with
     the provisions hereof shall be deemed a "Conversion Date." The Company will
     transmit  the  certificates  representing  the Common Stock  issuable  upon
     conversion  of all or any part of the  shares of Series B  Preferred  Stock
     (together  with  any  certificates  for  replacement  shares  of  Series  B
     Preferred  Stock not  previously  converted  but  included in the  original
     certificate  presented for  conversion)  to the Holder via express  courier
     within three (3) business  days after  counsel for the Company has received
     the original  Notice of Conversion and certificate for the shares of Series
     B  Preferred  Stock  being so  converted.  The  Notice  of  Conversion  and
     certificate  representing  the  portion of the shares of Series B Preferred
     Stock converted shall be delivered as follows:

                           To counsel:

                           Eilenberg & Zivian
                           666 Third Avenue, 30th Fl.
                           New York, NY  10017
                           (Tele) (212) 986-2468
                           (Fax) (212) 986-2399

                           To the Company:

                           Pharmos Corporation
                           2 Innovation Drive
                           Alachua, FL  32615
                           Attn:  President
                           (Tele) (904) 462-1210
                           (Fax) (904) 462-5401

     or to such other person at such other place as the Company shall  designate
     to the Holder in writing.

                                      E-47

<PAGE>




     In the event that the shares of Series B Preferred  Stock are not converted
within three (3) business  days of receipt by counsel for the Company of a valid
Notice of Conversion and  certificates  representing  the Shares to be converted
(such date of receipt referred to as the "Conversion  Date"),  the Company shall
be liable to Purchaser for actual damages  incurred from the fourth business day
following  the  Conversion  Date through the ninth  business day  following  the
Conversion  Date for such failure  (provided  that  Purchaser  has delivered the
original valid Notice of Conversion and the original certificate(s) representing
the shares of Series B Preferred  Stock to be  converted,  or an  affidavit  and
indemnity  agreement  as to lost  certificates  reasonably  satisfactory  to the
Company).  In the event  that the  shares of  Series B  Preferred  Stock are not
converted by the tenth (10th)  business day following the  Conversion  Date, the
Company shall pay to the Holder,  by wire  transfer,  as liquidated  damages for
such  failure and not as a penalty,  an amount in cash equal to one (1%) percent
per day of the  Liquidation  Preference  for the Series B Preferred  Stock to be
converted which shall run from the initial Conversion Date;  provided,  however,
that actual damages and liquidated damages for a failure to deliver certificates
of Common Stock shall be determined in accordance  with Section 5(g), if both of
the  following  conditions  are  satisfied  by the  Company:  (i) the failure to
deliver  certificates  of  Common  Stock is the  result  of a lack of  available
authorized but unissued  shares of Common Stock and (ii) the Company  commences,
within ten (10) business days after the initial  Conversion  Date,  and uses its
best  efforts  to  obtain   stockholder   approval  to  amend  its  Articles  of
Incorporation to increase the number of authorized  shares of Common Stock by an
amount sufficient to permit conversion of all shares of Series B Preferred Stock
then outstanding at the Hypothetical  Conversion Price (as hereinafter  defined)
then in effect.

               (i) Lost or Stolen  Certificates.  Upon receipt by the Company of
          evidence  of  the  loss,  theft,  destruction  or  mutilation  of  any
          certificates  representing shares of Series B Preferred Stock, and (in
          the case of loss,  theft or  destruction)  of  indemnity  or  security
          reasonably  satisfactory  to  the  Company,  and  upon  surrender  and
          cancellation of the  certificate(s),  if mutilated,  the Company shall
          execute  and  deliver  new  certificate(s)  of like  tenor  and  date.
          However,  Company  shall not be  obligated  to  re-issue  such lost or
          stolen  certificates if Holder  contemporaneously  requests Company to
          convert such Series B Preferred Stock into Common Stock.

               (ii) No  Fractional  Shares.  If any  conversion  of the Series B
          Preferred  Stock would create a fractional  share of Common Stock or a
          right to acquire a fractional  share of Common Stock,  such fractional
          share shall be  disregarded  and the number of shares of Common  Stock
          issuable upon conversion, shall be the next higher number of shares.

          (d)  Restrictions  on  Conversion  of the  Series B  Preferred  Stock.
     Notwithstanding  anything to the contrary  contained  herein,  no shares of
     Series B Preferred  Stock may be  converted by a Holder to the extent that,
     after giving  effect to the shares of Common Stock  issuable  pursuant to a
     Notice of  Conversion,  the total  number of shares of Common  Stock deemed
     beneficially owned by such Holder (other than by virtue of the ownership of
     the Series B Preferred Stock or the warrants issued to Holder in connection
     with the  issuance of the Series B Preferred  Stock or  ownership  of other
     securities  that  have  limitations  on a  Holder's  rights to  convert  or
     exercise similar to those limitations set forth herein),  together with all
     shares of Common Stock deemed  beneficially owned by Holder's  "affiliates"
     (as defined in Rule 144 under the Securities Act) that

                                      E-48

<PAGE>



     would be  aggregated  for  purposes  of  determining  whether a group under
     Section  13(d) of the Exchange Act exists,  would exceed 4.99% of the total
     issued and  outstanding  shares of Common Stock,  provided that each Holder
     shall  have  the  right  to waive  this  restriction,  in whole or in part,
     immediately in case of a pending Change in Control  Transaction (as defined
     in Section  5(b)(ii)(B)) and in any other case upon 61 days prior notice to
     the Company.  The delivery of a Notice of Conversion by any Holder shall be
     deemed a  representation  by such  Holder  it is in  compliance  with  this
     Section  5(d).  A transferee  of the Series B Preferred  Stock shall not be
     bound by this provision unless it expressly agrees to be so bound. The term
     "deemed  beneficially  owned" as used in this  Section  5(d) shall  exclude
     shares that might otherwise be deemed  beneficially  owned by reason of the
     convertibility of the Series B Preferred Stock.

          (e) Mandatory  Conversion.  The Series B Preferred Stock is subject to
     mandatory  conversion after three (3) years from the Closing Date, at which
     time all shares of Series B Preferred Stock will automatically be converted
     at the  Conversion  Price,  upon the terms set forth in this section.  Such
     three year period will be extended by the number of days during such period
     that (i) the  Company's  Common  Stock  has  been  Delisted  and/or  (ii) a
     Suspension  has been in effect and by the number of days after the 90th day
     from the date  hereof  that the  Registration  Statement  was not  declared
     effective.  Any  particular  day in which  more  than one of the  foregoing
     condition  events  shall have been in effect  shall only be counted once in
     determining  the number of days by which to extend  the three  year  period
     prior to mandatory conversion.  Mandatory conversion shall not occur in the
     event of the occurrence of one or both of the following at the time of such
     mandatory  conversion:  (x) the Company is unable, or admits in writing its
     inability,  to pay its debts,  or is not paying its debts generally as they
     come due, or has made any assignment  for the benefit of creditors;  or (y)
     the Company has commenced, or there has been commenced against the Company,
     any case,  proceeding,  or other action seeking to have an order for relief
     entered  with  respect to the Company,  or to  adjudicate  the Company as a
     bankrupt or insolvent.

          (f) Reservation of Stock Issuable Upon  Conversion.  The Company shall
     at all times reserve and keep  available out of its authorized but unissued
     shares of Common Stock,  such number of its shares of Common Stock as shall
     from  time to time be  sufficient  to  effect  the  conversion  of all then
     outstanding  shares of Series B Preferred  Stock,  the sufficiency of which
     shall  be  determined  by  using  a  Conversion  Price  (the  "Hypothetical
     Conversion Price") derived from a hypothetical closing market price that is
     75% of either (i) the actual  Average  Closing Price on the Closing Date or
     (ii) the  actual  Average  Closing  Price from time to time,  whichever  is
     lower.  The  Company  hereby  covenants  and agrees that if at any time the
     Hypothetical  Conversion  Price  falls to a level that would not enable all
     outstanding  shares of Series B Preferred Stock to be fully converted,  the
     Company will promptly use its best efforts to obtain stockholder  approval,
     within  90 days  thereafter,  to amend its  Articles  of  Incorporation  to
     increase  the  number of  authorized  shares  of Common  Stock by an amount
     sufficient  to permit the  conversion  of all shares of Series B  Preferred
     Stock then outstanding at the Hypothetical Conversion Price then in effect.

          (g)  Liquidated  Damages.  In the event of a  Delisting,  a Cumulative
     Suspension  or  Insufficient   Authorized   Stock,  or  in  the  event  the
     Registration  Statement is not effective within 90 days of the Closing Date
     (each a "Damage Event"), the Company will pay to all Holders of

                                      E-49

<PAGE>



     the Series B Preferred Stock, by wire transfer,  as liquidated  damages for
     such  non-availability  and not as a penalty, an amount in cash equal to 2%
     per month of the  Liquidation  Preference  of only those shares of Series B
     Preferred  Stock then eligible for  conversion,  without  regard to Section
     5(d), for the first two months after the occurrence of a Damage Event,  and
     3% per month for each month thereafter. Similar liquidated damages shall be
     paid with respect to any shares of Series B Preferred  Stock not  initially
     eligible for  conversion,  when the Damage  Event first  occurred but which
     subsequently  become  eligible for  conversion,  without  regard to Section
     5(d),  commencing in the first month that such shares of Series B Preferred
     Stock become eligible for such  conversion.  Such liquidated  damages shall
     continue  to accrue  and shall be payable  until the Damage  Event has been
     cured (and, if unpaid, shall bear interest at a rate of 2% per month), and,
     at the  Holder's  election,  may be paid in  cash  or may be  added  to the
     principal  of the  shares  of  Series  B  Preferred  Stock  for  subsequent
     conversion purposes;  provided,  however,  that in the case of a Delisting,
     after six months from the date of such  Delisting,  the Company  shall have
     the option to either (i) force  Holder to as promptly  as possible  convert
     (in increments of no less than $50,000) all or part of its shares of Series
     B Preferred  Stock,  subject to Purchaser being able to sell the underlying
     shares of Common Stock issuable upon conversion,  and  simultaneously  sell
     such  shares  (where  the  conversion  price  therefor  shall  not  be  the
     Conversion  Price but instead shall equal 83% of the Holder's sale price of
     the shares of Common  Stock  issued upon  conversion,  for the first 25% of
     Holder's Aggregated Liquidation Preference converted, and 80% of the actual
     sale price of the shares of Common  Stock  issued upon  conversion  for the
     remainder,  all as determined  by Holder's  actual  trading  records (to be
     provided  to the  Company)  or (ii)  redeem  Holder's  shares  of  Series B
     Preferred  Stock  pursuant  to Section  5(h)  below.  In no event,  may the
     Company  force  Holder to convert  less than  $50,000 of Series B Preferred
     Stock.

     (h) Redemption By Company.

          (i) Company's  Right to Redeem.  The Company shall have the right,  in
     its sole  discretion,  to redeem in whole or in part the Series B Preferred
     Stock when the average Nasdaq closing bid price is more than 200% above the
     Nasdaq closing price on the Closing Date for the five (5) consecutive  days
     prior to the date the Company makes such election to redeem. If the Company
     elects to redeem  some,  but not all,  of the shares of Series B  Preferred
     Stock,  the Company shall redeem the shares of Series B Preferred Stock pro
     rata  among  the  Holders  of all of the  Series  B  Preferred  Stock  then
     outstanding. The date of the Company's redemption of the Series B Preferred
     Stock shall be referred to as the "Redemption Date."

          (ii)  Redemption  Price.  The  redemption  price per share of Series B
     Preferred Stock shall equal: Liquidation Preference 80%

          (iii) Mechanics of Redemption; Holder's Conversion Rights. The Company
     shall  effect  each such  redemption  by giving  notice of its  election to
     redeem ("Redemption Notice"), which shall be irrevocable,  by facsimile, by
     5 P.M. New York City time the next  business day  following its election to
     redeem shares of Series B Preferred  Stock and shall provide a copy of such
     redemption  notice by  overnight  or 2-day  courier,  to Holder,  all other
     Holders of shares of

                                      E-50

<PAGE>



     Series B Preferred Stock and the Company's  transfer agent for the Series B
     Preferred Stock ("Transfer  Agent").  Such redemption notice shall indicate
     (i) whether  the Company  will redeem all or part of the Series B Preferred
     Stock,  (ii) the  applicable  redemption  price and (iii) that the  average
     Nasdaq  closing bid price has exceeded by 200% the Nasdaq  closing price on
     the Closing  Date for the five (5)  consecutive  days prior to the date the
     Company   elects  to  redeem   shares   of   Series  B   Preferred   Stock.
     Notwithstanding  the  foregoing,  Holder  shall  have  five  business  days
     following  receipt of the Redemption  Notice from the Company to elect,  in
     its sole discretion, to convert all or part of the Series B Preferred Stock
     otherwise being redeemed.  Such conversion  shall be effected in accordance
     with the  Certificate  of  Designation,  and if an  appropriate  Notice  of
     Conversion is delivered to the Company in a timely  manner,  such shares of
     Series B Preferred Stock shall be deemed to be converted and not redeemed.

          (iv)  Company  Must  Have   Immediately   Available  Funds  or  Credit
     Facilities. The Company shall not be entitled to send any Redemption Notice
     and begin the redemption procedure hereunder unless it has:

               (A) the full amount of the redemption price in cash, available in
          a demand or other  immediately  available account in a bank or similar
          financial institution; or

               (B) immediately  available credit facilities,  in the full amount
          of the redemption price with a bank or similar financial  institution;
          or

               (C) a  combination  of the items set forth in (A) and (B)  above,
          aggregating the full amount of the redemption price.

          (v) Payment of Redemption  Price.  Upon receipt of a Redemption Notice
     Holder shall send its shares of Series B Preferred  Stock being redeemed to
     the Company or its Transfer Agent, and the Company shall pay the applicable
     redemption price within three (3) business days of receipt of the shares of
     Series B Preferred Stock. The Company shall not be obligated to deliver the
     redemption  price unless the shares of Series B Preferred Stock so redeemed
     are delivered to the Company or its Transfer Agent, or, in the event one or
     more certificates have been lost,  stolen,  mutilated or destroyed,  Holder
     delivers to the Company a lost  certificate  affidavit and  indemnification
     agreement reasonably satisfactory to Company and the Transfer Agent.

          (vi) Blackout Period.  Notwithstanding the foregoing,  the Company may
     not either send out a  redemption  notice or effect a  redemption  during a
     Blackout Period (defined as a period during which the Company's officers or
     directors  would not be  entitled  to buy or sell  stock  because  of their
     holding  of  material  non-public  information).  In the event the  Company
     initiates a redemption  during a Blackout  Period without having first made
     public  material  non-public  information,  the Company shall  disclose the
     non-public  information  that  resulted  in  the  Blackout  Period,  and no
     redemption shall be effected until at least 10 days after the Company shall
     have given the Holder  written  notice  that the  Blackout  Period has been
     lifted.

          (i) Adjustment to Conversion Rate.


                                      E-51

<PAGE>



               (i)  Adjustment  to Fixed  Conversion  Price Due to Stock  Split,
          Stock Dividend,  Etc. If at any time when the Series B Preferred Stock
          is issued and outstanding,  the number of outstanding shares of Common
          Stock is increased by a stock split, stock dividend,  or other similar
          event, the Conversion Price shall be  proportionately  reduced,  or if
          the number of  outstanding  shares of Common  Stock is  decreased by a
          reverse stock split,  combination or  reclassification  of shares,  or
          other similar  event,  the Conversion  Price shall be  proportionately
          increased.  In such event the Company shall notify the Transfer  Agent
          of such change on or before the effective date thereof.

               (ii) Adjustment Due to Merger,  Consolidation,  Etc. If, prior to
          the  conversion  of all Series B Preferred  Stock,  there shall be any
          merger,   consolidation,   exchange   of   shares,   recapitalization,
          reorganization, or other similar event, as a result of which shares of
          Common  Stock  of the  Company  shall  be  changed  into the same or a
          different  number of shares of the same or another class or classes of
          stock  or  securities  of the  Company  or  another  entity,  or other
          property,  then the Holders of Series B Preferred  Stock  shall,  upon
          being  given  at  least  30  days  advance   written  notice  of  such
          transaction,  thereafter  have the right to purchase  and receive upon
          conversion  of Series B Preferred  Stock,  upon the basis and upon the
          terms and  conditions  specified  herein  and in lieu of the shares of
          Common Stock immediately  theretofore  issuable upon conversion,  such
          shares of stock and/or  securities or other  property as may be issued
          or payable  with respect to or in exchange for the number of shares of
          Common Stock immediately  theretofore  purchasable and receivable upon
          the  conversion  of Series B Preferred  Stock held by such Holders had
          such merger,  consolidation,  exchange of shares,  recapitalization or
          reorganization  not  taken  place,  and in any such  case  appropriate
          provisions  shall be made with respect to the rights and  interests of
          the  Holders  of the  Series  B  Preferred  Stock  to the end that the
          provisions  hereof  (including,  without  limitation,  provisions  for
          adjustment of the Conversion Rate and of the number of shares issuable
          upon conversion of the Series B Preferred  Stock) shall  thereafter be
          applicable,  as nearly as may be practicable in relation to any shares
          of stock or  securities  thereafter  deliverable  upon the  conversion
          thereof.  The Company  shall not effect any  transaction  described in
          this subsection 5(f) unless (1) Holder has been given at least 30 days
          advance  written  notice of such  transaction,  and (2) the  resulting
          successor or acquiring  entity (if not the Company) assumes by written
          instrument  the  obligation  to deliver to the Holders of the Series B
          Preferred  Stock  such  shares  of stock  and/or  securities  or other
          property as, in accordance with the foregoing provisions,  the Holders
          of the  Series B  Preferred  Stock may be  entitled  to  receive  upon
          conversion of the Series B Preferred Stock.

               (iii) No Fractional  Shares. If any adjustment under this Section
          5(i) would  create a  fractional  share of Common  Stock or a right to
          acquire a fractional  share of Common  Stock,  such  fractional  share
          shall be disregarded and the number of shares of Common Stock issuable
          upon conversion shall be the next higher number of shares.

     Section 6. Voting Rights. The Holders of the Series B Preferred Stock shall
have no voting power  whatsoever,  except with  respect to any  amendment to the
Company's Certificate of Incorporation which would have an adverse effect on the
Series B Preferred  Stock or as  otherwise  provided  by the Nevada  Corporation
Laws.


                                      E-52

<PAGE>



     Section 7. Status of Converted  Stock.  In the event any shares of Series B
Preferred Stock shall be converted  pursuant to Section 5 hereof,  the shares so
converted  shall be  canceled,  shall  return to the  status of  authorized  but
unissued  Preferred Stock of no designated  series, and shall not be issuable by
the Company as Series B Preferred Stock.

     Section 8. Preference  Rights.  Nothing contained herein shall be construed
to prevent the Board of Directors of the Company from issuing one or more series
of Preferred Stock with dividend and/or  liquidation  preferences  junior to the
dividend and liquidation preferences of the Series B Preferred Stock.


                                      E-53

<PAGE>



                                                                       EXHIBIT A

                              NOTICE OF CONVERSION
        (To be Executed by the Registered Holder in order to Convert the
                              5% Preferred Stock)

The undersigned hereby  irrevocably elects to convert the ___Shares  represented
by above Certificate No. ____ into shares of common stock of PHARMOS CORPORATION
(the  "Company")  according  to the  conditions  hereof,  as of the date written
below.

The undersigned represents and warrants that

     All  offers  and sales by the  undersigned  of the  shares of Common  Stock
     issuable to the undersigned upon conversion of the Preferred Stock shall be
     made pursuant to an exemption from registration  under the Act, or pursuant
     to  registration  of the Common Stock under the  Securities Act of 1933, as
     amended.


- --------------------------------                     ---------------------------
Date of Conversion                                   Applicable Conversion Price


- --------------------------------                     ---------------------------
Number of Shares of Common Stock                     $ Amount of Conversion
upon Conversion



- --------------------------------                     ---------------------------
Signature                                            Name

Address:                                             Delivery of Shares to:

                                      E-54

<PAGE>




                                                                      EXHIBIT B1


                               PHARMOS CORPORATION

                             COMPLIANCE CERTIFICATE


     The  undersigned,  an  executive  officer  of PHARMOS  CORPORATION,  hereby
certifies that the representations and warranties made by Pharmos Corporation in
the 5%  Preferred  Stock  Securities  Purchase  Agreement  dated  March 31, 1997
between Pharmos  Corporation and  _____________  were true and correct as of the
date such  representations  and warranties were made and are true and correct in
all  material  respects  as of the date hereof with the same force and effect as
through such  representations and warranties had been made on and as of the date
hereof.

     IN WITNESS WHEREOF,  the undersigned has signed this Certificate as of this
31st day of March 1997.

                                            PHARMOS CORPORATION


                                            By
                                              ----------------------------------
                                            Name
                                                --------------------------------
                                            Title
                                                 -------------------------------



                                      E-55

<PAGE>



                                                                      EXHIBIT B2


                                    PURCHASER

                             COMPLIANCE CERTIFICATE


     The   undersigned,   _________________,    _________________________,    of
______________________________________  ("Purchaser"), hereby certifies that the
representations  and  warranties  made by Purchaser  in the 5%  Preferred  Stock
Securities  Purchase Agreement dated March 31, 1997 between Pharmos  Corporation
and  Purchaser  were true and  correct as of the date such  representations  and
warranties were made and are true and correct in all material respects as of the
date hereof with the same force and effect as through such  representations  and
warranties had been made on and as of the date hereof.

     IN WITNESS WHEREOF,  the undersigned has signed this Certificate as of this
31st day of March 1997.

                                                       PURCHASER

                                                 --------------------------

                                                 By
                                                   -----------------------------

                                                 Name
                                                     ---------------------------
                                                 Title
                                                     ---------------------------



                                      E-56

<PAGE>



                                                                       EXHIBIT C

                              NOTICE OF CONVERSION

       (To be Executed by the Registered Holder in order to Convert the 5%
                                Preferred Stock)

The undersigned hereby  irrevocably elects to convert the ___Shares  represented
by above Certificate No. ____ into shares of common stock of PHARMOS CORPORATION
(the  "Company")  according  to the  conditions  hereof,  as of the date written
below.

The undersigned represents and warrants that

     All  offers  and sales by the  undersigned  of the  shares of Common  Stock
          issuable to the  undersigned  upon  conversion of the Preferred  Stock
          shall be made  pursuant to an exemption  from  registration  under the
          Act,  or  pursuant  to  registration  of the  Common  Stock  under the
          Securities Act of 1933, as amended.
- ---------------------------------             ----------------------------------
 Date of Conversion                           Applicable Conversion Price

- --------------------------------              ----------------------------------
Number of Shares of Common Stock              $ Amount of Conversion
upon Conversion

- ---------------------------------             ----------------------------------
 Signature                                    Name

 Address:                                     Delivery of Shares to:


                                      E-57

<PAGE>




                                                                    EXHIBIT 4(h)












                                      E-58

<PAGE>



                 [FORM OF STOCK PURCHASE WARRANT WITH INVESTORS]

THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE UNITED STATES  SECURITIES AND
EXCHANGE  COMMISSION OR THE  SECURITIES  COMMISSION OF ANY STATE  PURSUANT TO AN
EXEMPTION FROM REGISTRATION  UNDER REGULATION D PROMULGATED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE "1933 ACT").  THIS STOCK PURCHASE WARRANT SHALL NOT
CONSTITUTE AN OFFER TO SELL NOR A SOLICITATION OF AN OFFER TO BUY THE SECURITIES
IN ANY JURISDICTION IN WHICH SUCH OFFER OR SOLICITATION  WOULD BE UNLAWFUL.  THE
SECURITIES  ARE  "RESTRICTED"  AND MAY NOT BE  RESOLD OR  TRANSFERRED  EXCEPT AS
PERMITTED UNDER THE 1933 ACT PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM.

No. W-97D-__

                             STOCK PURCHASE WARRANT
                  To Purchase ______ Shares of Common Stock of

                               PHARMOS CORPORATION


     THIS CERTIFIES that, for value received,  ______________  (the "Investor"),
is entitled, upon the terms and subject to the conditions hereinafter set forth,
at any time on or after March 31, 1998 (the "Initial  Exercise  Date") and on or
prior  to March  31,  2001  (the  "Termination  Date")  but not  thereafter,  to
subscribe for and purchase from PHARMOS  CORPORATION,  a Nevada corporation (the
"Company"),  ______ shares of the Company's Common Stock (the "Warrant Shares").
The purchase  price of one share of Common Stock (the  "Exercise  Price")  under
this Warrant shall be One Dollar and  Seventy-Five  Cents ($1.75).  The Exercise
Price and the  number of  Warrant  Shares  shall be  subject  to  adjustment  as
provided  herein.  This  warrant  is being  issued  pursuant a  Preferred  Stock
Securities  Purchase  Agreement,  dated March 31, 1997, complete with all listed
exhibits thereto (the  "Agreement")  between the Company and the Investor and is
subject to its terms.  In the event of any  conflict  between  the terms of this
Warrant and the Agreement, the Agreement shall control.

     1.  Title of  Warrant.  Prior  to the  expiration  hereof  and  subject  to
compliance  with  applicable  laws,  this Warrant and all rights  hereunder  are
transferable,  in whole or in part,  at the office or agency of the Company,  by
the holder hereof in person or by duly  authorized  attorney,  upon surrender of
this Warrant together with the Assignment Form annexed hereto properly endorsed.

     2. Authorization of Shares. The Company covenants that all shares of Common
Stock  which may be issued  upon the  exercise  of  rights  represented  by this
Warrant will, upon exercise of the rights  represented by this Warrant,  be duly
authorized,  validly  issued,  fully  paid and  nonassessable  and free from all
taxes,  liens and charges in respect of the issue  thereof  (other than taxes in
respect of any transfer occurring contemporaneously with such issue).


                                      E-59

<PAGE>



     3. Exercise of Warrant. Exercise of the purchase rights represented by this
Warrant may be made at any time or times,  in whole or in part,  on or after the
Initial  Exercise  Date,  or such earlier  date as provided in  paragraph  11(c)
below, and before the close of business on the Termination Date, or such earlier
date on which this Warrant may  terminate as provided in paragraph  11(a) below,
by the surrender of this Warrant and the  Subscription  Form annexed hereto duly
executed,  at the office of the Company  (or such other  office or agency of the
Company as it may designate by notice in writing to the registered holder hereof
at the address of such holder  appearing  on the books of the  Company) and upon
payment of the Exercise  Price of the shares  thereby  purchased;  whereupon the
holder of this Warrant shall be entitled to receive a certificate for the number
of shares of Common Stock so purchased immediately. In the event upon exercising
the Warrant,  the  transfer  agent  requires an opinion of counsel,  the Company
shall have such opinion  furnished to the transfer agent to the transfer agent's
satisfaction.  In the  event  the  Investor  is  relying  on an  exemption  from
registration under the 1933 Act, the Shares shall be issued immediately,  if the
Investor  furnishes  an  opinion  of  counsel,  reasonably  satisfactory  to the
Company,  that such exemption from  registration is available.  Certificates for
shares purchased  hereunder shall be delivered to the holder hereof within three
business days after the date on which this Warrant shall have been  exercised as
aforesaid. Payment of the Exercise Price of the shares may be by certified check
or cashier's  check or by wire transfer to an account  designated by the Company
in an amount  equal to the  Exercise  Price  multiplied  by the number of shares
being purchased.

     4.  No  Fractional   Shares  or  Scrip.  No  fractional   shares  or  scrip
representing  fractional  shares  shall  be  issued  upon the  exercise  of this
Warrant.

     5. Charges,  Taxes and  Expenses.  Issuance of  certificates  for shares of
Common Stock upon the exercise of this Warrant  shall be made without  charge to
the holder hereof for any issue or transfer tax or other  incidental  expense in
respect of the  issuance of such  certificate,  all of which taxes and  expenses
shall be paid by the Company,  and such certificates shall be issued in the name
of the holder of this Warrant or in such name or names as may be directed by the
holder of this Warrant;  provided,  however,  that in the event certificates for
shares of Common  Stock  are to be issued in a name  other  than the name of the
holder of this  Warrant,  this Warrant when  surrendered  for exercise  shall be
accompanied by the Assignment  Form attached  hereto duly executed by the holder
hereof, together with evidence satisfactory to the Company that such transfer or
assignment is being made in  compliance  with all  applicable  federal and state
securities laws; and provided  further,  that upon any transfer  involved in the
issuance or delivery of any certificates for shares of Common Stock, the Company
may  require,  as a  condition  thereto,  the  payment  of a sum  sufficient  to
reimburse it for any transfer tax incidental thereto.

     6.  Closing of Books.  The  Company  will at no time close its  shareholder
books or records in any manner which interferes with the timely exercise of this
Warrant.

     7. No Rights as Shareholder  until Exercise.  This Warrant does not entitle
the holder hereof to any voting  rights or other rights as a shareholder  of the
Company prior to the exercise thereof. If, however, at the time of the surrender
of this  Warrant and  purchase  the holder  hereof shall be entitled to exercise
this Warrant, the shares so purchased shall be and be

                                      E-60

<PAGE>



deemed to be issued to such holder as the record  owner of such shares as of the
close of business on the date on which this Warrant shall have been exercised.

     8. Assignment and Transfer of Warrant.  This Warrant may be assigned by the
surrender of this Warrant and the  Assignment  Form annexed hereto duly executed
at the office of the Company  (or such other  office or agency of the Company as
it may  designate by notice in writing to the  registered  holder  hereof at the
address  of such  holder  appearing  on the  books  of the  Company);  provided,
however, that this Warrant may not be resold or otherwise transferred except (i)
in a transaction  registered  under the Securities Act, or (ii) in a transaction
pursuant to an exemption,  if available,  from such registration and whereby, if
requested by the Company,  an opinion of counsel reasonably  satisfactory to the
Company  is  obtained  by the  holder of this  Warrant  to the  effect  that the
transaction is so exempt.

     9.  Loss,  Theft,   Destruction  or  Mutilation  of  Warrant.  The  Company
represents and warrants that upon receipt by the Company of evidence  reasonably
satisfactory to it of the loss, theft,  destruction or mutilation of any Warrant
or stock certificate, and in case of loss, theft or destruction, of indemnity or
security reasonably satisfactory to it, and upon reimbursement to the Company of
all reasonable expenses incidental thereto,  and upon surrender and cancellation
of such Warrant or stock  certificate,  if mutilated,  the Company will make and
deliver a new  Warrant or stock  certificate  of like tenor and dated as of such
cancellation, in lieu of this Warrant or stock certificate.

     10. Saturdays, Sundays, Holidays, etc. If the last or appointed day for the
taking of any action or the  expiration of any right  required or granted herein
shall be a Saturday, Sunday or a legal holiday, then such action may be taken or
such right may be exercised on the next succeeding day not a legal holiday.

     11. Effect of Certain Events.

          (a) If at any  time  the  Company  proposes  (i) to sell or  otherwise
     convey  all  or  substantially  all of its  assets  or  (ii)  to  effect  a
     transaction  (by merger or  otherwise) in which more than 50% of the voting
     power of the  Company  is  disposed  of  (collectively,  a "Sale or  Merger
     Transaction"),  in which the consideration to be received by the Company or
     its shareholders consists solely of cash, the Company shall give the holder
     of this Warrant thirty (30) days' notice of the proposed  effective date of
     the transaction  specifying that the Warrant shall terminate if the Warrant
     has not been exercised by the effective date of the transaction.

          (b) In case the  Company  shall at any  time  effect a Sale or  Merger
     Transaction in which the consideration to be received by the Company or its
     shareholders  consists in part of  consideration  other than cash, or shall
     issue any shares of its capital stock in a  reclassification  of the Common
     Stock,  the  holder of this  Warrant  shall  have the right  thereafter  to
     purchase, by exercise of this Warrant and payment of the aggregate Exercise
     Price in effect  immediately  prior to such action,  the kind and amount of
     shares and other  securities and property which it would have owned or have
     been entitled to receive after the happening of such  transaction  had this
     Warrant been exercised immediately prior thereto.


                                      E-61

<PAGE>



          (c) The Initial  Exercise Date shall be  accelerated in the event of a
     Change in  Control or a Going  Private  Transaction,  as defined  under the
     Agreement.

     12.  Registration  Rights.  The Company shall  register the Warrant  Shares
pursuant  to  Section 7 of the  Agreement.  In the event of the  failure  of the
Company to procure  registration  of the Warrant  Shares by the later of (i) the
Initial  Exercise  Date, as adjusted  pursuant to paragraph  11(c) above or (ii)
ninety (90) days from the Closing Date (as defined in the Agreement),  or during
a  Suspension,  as defined  under the  Agreement,  the  Company  will pay to the
Investor by wire transfer,  as liquidated  damages for such failure and not as a
penalty, two (2%) percent of the product of the Exercise Price and the number of
Warrants that have not been exercised,  for each of the first two (2) months and
three (3%) percent per month thereafter that the  registration  statement is not
effective or that such Suspension continues.  If not paid as required,  interest
on such damages  will accrue at a rate of 2% per month.  If the Company does not
remit the damages to the Investor as set forth  above,  the Company will pay the
Investor  reasonable costs of collection,  including attorneys fees, in addition
to  the  liquidated  damages.  Such  payment  shall  be  made  to  the  Investor
immediately  if the  registration  of the  Warrant  Shares is not  effected  and
maintained; provided, however, that the payment of such liquidated damages shall
not relieve the Company  from its  obligations  to register  the Warrant  Shares
pursuant to this paragraph 12. The  registration  of the Warrant Shares pursuant
to this provision shall not effect or limit  Investor's other rights or remedies
as set  forth  in this  Warrant.  The  obligations  of the  Company  under  this
paragraph  12 shall  cease and  terminate  upon the earlier to occur of (x) such
time as all of the Warrant  Shares have been  re-sold or (y) such time as all of
the Warrant  Shares may be re-sold  pursuant to Rule 144(k) under the Securities
Act.


     13.  Adjustments of Exercise Price and Number of Warrant Shares. The number
and kind of  securities  purchasable  upon the  exercise of this Warrant and the
Exercise  Price  shall be  subject  to  adjustment  from  time to time  upon the
happening of certain events, as hereinafter set forth:

          (a) In case the Company shall at any time  subdivide  its  outstanding
     shares of Common Stock  ("Common  Shares") into a greater  number of Common
     Shares or declare a dividend or distribution upon its Common Shares payable
     in Common Shares,  the Exercise Price in effect  immediately  prior to such
     subdivision or declaration shall be proportionately reduced, and the number
     of  Warrant  Shares  issuable  upon  exercise  of  the  Warrants  shall  be
     proportionately  increased.  Conversely,  in case  the  outstanding  Common
     Shares of the  Company  shall be combined  into a smaller  number of Common
     Shares,  the Exercise Price in effect immediately prior to such combination
     shall be  proportionately  increased,  and the  number  of  Warrant  Shares
     issuable upon exercise of the Warrants shall be proportionately reduced.

          (b) In case the  Company  shall issue  rights,  options or warrants to
     holders of its outstanding Common Stock entitling them (for a period within
     45 days after the record date mentioned below) to subscribe for or purchase
     shares of Common Stock or securities  convertible  into or  exchangeable or
     exercisable  for Common Stock at a Price Per Share (as defined in paragraph
     (d) below)  which is lower at the date of  issuance  thereof  than the then
     Current  Market  Price (as  defined  in  paragraph  (e) below) per share of
     Common Stock at such date, the number

                                      E-62

<PAGE>



     of Warrant Shares  hereafter  purchasable upon the exercise of this Warrant
     shall be determined by multiplying the number of Warrant Shares theretofore
     purchasable  upon  exercise  of this  Warrant by a  fraction,  of which the
     numerator shall be the number of shares of Common Stock  outstanding on the
     date of issuance  of such  rights,  options or warrants  plus the number of
     additional  shares of Common Stock  actually  subscribed for and purchased,
     and of which the denominator  shall be the number of shares of Common Stock
     outstanding  on the date of  issuance of such  rights,  options or warrants
     plus the number of shares of Common Stock which the aggregate  Proceeds (as
     defined in paragraph (d) below) received by the Company on exercise of such
     rights, options and warrants would purchase at the Current Market Price per
     share of Common  Stock at the date of issuance of such  rights,  options or
     warrants.  Such adjustment  shall be made whenever such rights,  options or
     warrants are issued, and shall become effective on the date of distribution
     retroactive  to the  record  date  for the  determination  of  stockholders
     entitled to receive such rights, options or warrants.

          (c) In case the Company  shall  distribute to holders of its shares of
     Common Stock evidences of its indebtedness or assets  (excluding  dividends
     or  distributions  referred to in paragraph  (a) above or in the  paragraph
     immediately   following  this  paragraph  and  excluding  any  dividend  or
     distribution  paid out of the retained  earnings of the Company) or rights,
     options or warrants,  or convertible or exchangeable  securities containing
     the right to subscribe  for or purchase  shares of Common Stock  (excluding
     those referred to in paragraph (b) above),  then in each case the number of
     Warrant  Shares  thereafter  purchasable  upon the exercise of this Warrant
     shall be determined by multiplying the number of Warrant Shares theretofore
     purchasable  upon the exercise of this Warrant by a fraction,  of which the
     numerator  shall be the then Current Market Price per share of Common Stock
     on the date of such  distribution,  and of which the  denominator  shall be
     such Current  Market Price,  less the then fair value (as determined by the
     Board  of  Directors  of the  Company)  of the  portion  of the  assets  or
     evidences of  indebtedness so distributed or of such  subscription  rights,
     options or warrants,  or of such  convertible  or  exchangeable  securities
     applicable  to one share of Common  Stock.  Such  adjustment  shall be made
     whenever any such  distribution is made, and shall become  effective on the
     date of distribution  retroactive to the record date for the  determination
     of shareholders entitled to receive such distribution.

          (d) For  purposes  of this  Section  13,  "Price Per  Share"  shall be
     defined and determined according to the following formula:

                           R
                  P = ------------
                           N

         where

                  P =      Price Per Share,

                           R = the  "Proceeds"  received  or  receivable  by the
                           Company  which  (i) in the case of  shares  of Common
                           Stock is the total amount  received or  receivable by
                           the  Company  in  consideration   for  the  sale  and
                           issuance of such shares;




                                      E-63

<PAGE>



               (ii) in the case of rights,  options or warrants to subscribe for
          or purchase shares of Common Stock or of securities  convertible  into
          or  exchangeable  or  exercisable  for shares of Common Stock,  is the
          total amount  received or receivable  by the Company in  consideration
          for the  sale  and  issuance  of such  rights,  options,  warrants  or
          convertible  or  exchangeable  or  exercisable  securities,  plus  the
          minimum aggregate amount of additional  consideration,  other than the
          surrender of such convertible or exchangeable  securities,  payable to
          the Company upon exercise,  conversion or exchange thereof;  and (iii)
          in the  case of  rights,  options  or  warrants  to  subscribe  for or
          purchase convertible or exchangeable or exercisable securities, is the
          total amount  received or receivable  by the Company in  consideration
          for the sale and  issuance of such rights,  options or warrants,  plus
          the minimum  aggregate amount of additional  consideration  other than
          the surrender of such convertible or exchangeable securities,  payable
          upon the exercise,  conversion or exchange of such rights,  options or
          warrants  and upon the  conversion  or  exchange  or  exercise  of the
          convertible or exchangeable or exercisable  securities;  provided that
          in each case the proceeds  received or receivable by the Company shall
          be deemed to be the gross cash proceeds  without  deducting  therefrom
          any compensation paid or discount allowed in the sale, underwriting or
          purchase  thereof  by  underwriters  or  dealers  or other  performing
          similar services or any expenses incurred in connection therewith,

     and

     N =  the "Number of shares,"  which (i) in the case of Common  Stock is the
          number  of  shares  issued;  (ii) in the case of  rights,  options  or
          warrants to  subscribe  for or purchase  shares of Common  Stock or of
          securities  convertible into or exchangeable or exercisable for shares
          of Common  Stock,  is the  maximum  number  of shares of Common  Stock
          initially issuable upon exercise,  conversion or exchange thereof; and
          (iii) in the case of rights,  options or warrants to subscribe  for or
          purchase convertible or exchangeable or exercisable securities, is the
          maximum  number  of shares of Common  Stock  initially  issuable  upon
          conversion,  exchange or exercise of the convertible,  exchangeable or
          exercisable  securities  issuable  upon the  exercise of such  rights,
          options or warrants.

     If the  Company  shall  issue  shares of Common  Stock or rights,  options,
warrants  or  convertible  or  exchangeable  or  exercisable  securities  for  a
consideration  consisting, in whole or in part, of property other than cash, the
amount of such  consideration  shall be determined in good faith by the Board of
Directors of the Company whose determination shall be conclusive.

          (e) For the purpose of any  computation  under  paragraphs (b), (c) or
     (d) of this  Section  13, the  "Current  Market  Price" per share of Common
     Stock at any date shall be the average of the Closing  NASDAQ  Price of the
     Common Stock for the thirty (30) trading  days  commencing  30 trading days
     before  the date of  determination.  If the  Common  Stock is not traded on
     Nasdaq, the Current Market Price shall be the average closing price (and if
     not

                                      E-64

<PAGE>



     available,  the mean of the high and low prices) of the Common Stock on the
     over-the-counter-market  or the principal national  securities  exchange or
     the  National  Market  System on which the  Common  Stock is traded for the
     thirty (30)  trading  days  commencing  30 trading  days before the date of
     determination.

          (f)  Whenever  the  number  of  Warrant  Shares  purchasable  upon the
     exercise of this  Warrant is  adjusted,  as herein  provided,  the Exercise
     Price   payable  upon  exercise  of  this  Warrant  shall  be  adjusted  by
     multiplying such Exercise Price  immediately  prior to such adjustment by a
     fraction,  of which the  numerator  shall be the number of  Warrant  Shares
     purchasable  upon the  exercise of this Warrant  immediately  prior to such
     adjustment,  and of which the  denominator  shall be the  number of Warrant
     Shares purchasable immediately thereafter.

          (g)  No  adjustment  in  the  number  of  Warrant  Shares  purchasable
     hereunder  shall be required  unless  such  adjustment  would  result in an
     increase or decrease of at least one percent  (1%)  percent of the Exercise
     Price;  provided that any adjustments which by reason of this paragraph (h)
     are not required to be made shall be carried forward and taken into account
     in any subsequent adjustment. All calculations shall be made to the nearest
     cent or to the nearest one-thousandth of a share, as the case may be.

          (h) No adjustment in the number of Warrant Shares purchasable upon the
     exercise of this  Warrant need be made under  paragraph  (b), (c) or (d) if
     the Company issues or distributes to the holder of this Warrant the shares,
     rights,  options,  warrants or convertible or exchangeable  securities,  or
     evidences of indebtedness or assets referred to in those  paragraphs  which
     the holder of this  Warrant  would have been  entitled  to receive had this
     Warrant been  exercised  prior to the happening of such event or the record
     date with  respect  thereto.  In no event  shall the Company be required or
     obligated  to  make  any  such  distribution  otherwise  than  in its  sole
     discretion.  No adjustment in the number of Warrant shares purchasable upon
     the  exercise  of this  Warrant  need be made  for  sales of  Common  Stock
     pursuant to a Company plan for  reinvestment  of dividends or interest.  No
     adjustment need be made for a change in the par value of the Common Stock.

          (i) In the event that at any time, as a result of an  adjustment  made
     pursuant to paragraph  (a) above,  the holder of this Warrant  shall become
     entitled to purchase  any  securities  of the Company  other than shares of
     Common  Stock,  thereafter  the number of such other shares so  purchasable
     upon  exercise of this Warrant and the Exercise  Price of such shares shall
     be  subject  to  adjustment  from time to time in a manner  and on terms as
     nearly  equivalent as  practicable  to the  provisions  with respect to the
     Warrant Shares contained in paragraphs (a) through (i), inclusive, above.

     14. Voluntary  Adjustment by the Company. The Company may at its option, at
any time during the term of this Warrant, reduce the then current Exchange Price
to any  amount  and for any period of time  deemed  appropriate  by the Board of
Directors of the Company.


                                      E-65

<PAGE>



     15. Notice of  Adjustment.  Whenever the number of Warrant shares or number
or kind of securities or other  property  purchasable  upon the exercise of this
Warrant or the Exercise Price is adjusted, as herein provided, the Company shall
promptly mail by registered or certified mail, return receipt requested,  to the
transfer  agent for the Common Stock and to the holder of this Warrant notice of
such  adjustment or adjustments  setting forth the number of Warrant Shares (and
other securities or property)  purchasable upon the exercise of this Warrant and
the Exercise Price of such Warrant Shares after such adjustment, setting forth a
brief  statement  of the facts  requiring  such  adjustment  and  setting  forth
computation  by which  such  adjustment  was made.  Such  notice,  in absence of
manifest  error,  shall  be  conclusive  evidence  of the  correctness  of  such
adjustment.

     16.  Authorized  Shares.  The Company  covenants that during the period the
Warrant is outstanding,  it will reserve from its authorized and unissued Common
Stock a sufficient  number of shares to provide for the issuance of Common Stock
upon the exercise of any purchase rights under this Warrant. Such reservation of
shares of Common  Stock  shall be in addition  to those  shares of Common  Stock
reserved  pursuant to the Company's  Certificate of Designation for its Series B
Preferred Stock. The Company further covenants that its issuance of this Warrant
shall constitute full authority to its officers who are charged with the duty of
executing stock certificates to execute and issue the necessary certificates for
shares of the  Company's  Common Stock upon the exercise of the purchase  rights
under this Warrant.  The Company will take all such reasonable  action as may be
necessary  to assure that such shares of Common  Stock may be issued as provided
herein  without  violation  of  any  applicable  law  or  regulation,  or of any
requirements of NASDAQ or any domestic securities exchange upon which the Common
Stock may be listed.

     17.  Restrictions  on  Exercise.  Notwithstanding  anything to the contrary
contained  herein,  no  Warrants  may  be  converted  by a  holder  of  Warrants
("Holder") to the extent that, after giving effect to the shares of Common Stock
issued  pursuant to the  exercise  hereof,  the total number of shares of Common
Stock  deemed  beneficially  owned by such  Holder  (other than by virtue of the
ownership of shares of Series A Preferred  Stock or Series B Preferred  Stock or
Warrants or ownership of other  securities  that have  limitations on a Holder's
rights to convert or exercise  similar to those  limitations  set forth herein),
together with all shares of Common Stock deemed  beneficially  owned by Holder's
"affiliates"  (as  defined  in Rule  144  under  the  1933  Act)  that  would be
aggregated  for purposes of  determining  whether a group under Section 13(d) of
the Securities Exchange Act of 1934, as amended,  exists,  would exceed 4.99% of
the total issued and  outstanding  shares of Common  Stock,  provided  that each
Holder  shall  have the right to waive  this  restriction,  in whole or in part,
immediately  in case of a pending Change in Control  Transaction  (as defined in
the  Agreement)  and in any  other  case  upon 61  days  prior  to the  exercise
hereunder  by Holder.  The exercise of all or part of this Warrant by any Holder
shall be deemed a  representation  by such Holder it is in compliance  with this
Section 17. A transferee of Warrants shall not be bound by this provision unless
it expressly agrees to be so bound. The term "deemed beneficially owned" as used
in this  Section  17  shall  exclude  shares  that  might  otherwise  be  deemed
beneficially owned by reason of the exercisability of the Warrants.

     18. Miscellaneous.


                                      E-66


<PAGE>




          (a) Issue Date.  The provisions of this Warrant shall be construed and
     shall  be  given  effect  in all  respects  as if it had  been  issued  and
     delivered by the Company on the date hereof.  This Warrant shall be binding
     upon  any  successors  or  assigns  of  the  Company.  This  Warrant  shall
     constitute a contract under the laws of New York and for all purposes shall
     be  construed  in  accordance  with and  governed by the laws of said state
     without regard to its conflict of law, principles or rules.

          (b) Restrictions. The holder hereof acknowledges that the Common Stock
     acquired upon the exercise of this  Warrant,  if not  registered,  may have
     restrictions upon its resale imposed by state and federal securities laws.

          (c)  Modification and Waiver.  This Warrant and any provisions  hereof
     may be changed,  waived,  discharged or terminated only by an instrument in
     writing  signed  by the  party  against  which  enforcement  of the same is
     sought.

          (d)  Notices.  Any  notice,  request  or other  document  required  or
     permitted  to be given or  delivered  to the holders  hereof or the Company
     shall be  delivered  or  shall be sent by  certified  or  registered  mail,
     postage  prepaid,  or by  overnight  courier or by  facsimile  to each such
     holder at its  address (or fax number) as shown on the books of the Company
     or to the  Company  at  the  address  (or  fax  number)  set  forth  in the
     Agreement.


                                      E-67

<PAGE>




     IN WITNESS  WHEREOF,  the Company has caused this Warrant to be executed by
its officers thereunto duly authorized.


Dated:  March 31, 1997

                                       PHARMOS CORPORATION



                                       By
                                         ------------------------------
                                                  Officer





                                      E-68


<PAGE>




                                 ASSIGNMENT FORM

                    (To assign the foregoing warrant, execute
                   this form and supply required information.
                    Do not use this form to purchase shares.)


     FOR VALUE RECEIVED,  the foregoing Warrant and all rights evidenced thereby
are hereby assigned to

_______________________________________________ whose address is ______________

__________________________________________________.



                                                   Dated: ______________, 199_



                               Holder's Signature:
                                                 -----------------------------

                               Holder's Address:
                                                 -----------------------------

                                                 -----------------------------


Signature Guaranteed: ___________________________________________


NOTE: The signature to this  Assignment Form must correspond with the name as it
appears on the face of the Warrant,  without  alteration or  enlargement  or any
change whatsoever,  and must be guaranteed by a bank or trust company.  Officers
of  corporations  and  those  acting  in an  fiduciary  or other  representative
capacity  should  file  proper  evidence of  authority  to assign the  foregoing
Warrant.


                                      E-69

<PAGE>



                         [FORM OF ELECTION TO PURCHASE]

     The  undersigned   hereby   irrevocably   elects  to  exercise  the  right,
represented  by this Warrant  Certificate,  to  purchase______  Shares of Common
Stock at an Exercise  Price of $_________ , and herewith  tenders in payment for
such  securities a certified  check or official  bank check  payable in New York
Clearing  House  Funds to the  order of  Pharmos  Corporation  in the  amount of
$___________ , all in accordance with the terms of the Stock Purchase Warrant of
Pharmos  Corporation,  dated March 31, 1997.  The  undersigned  requests  that a
certificate  for such  securities be  registered in the name of _________  whose
address   is_________________   and   that   such   Certificate   be   delivered
to_______________ whose address is_____________________ .

Dated:
                                            Signature
                                                     ---------------------------
                                                     (Signature  must conform in
                                                     all  respects  to  name  of
                                                     holder as  specified on the
                                                     face    of   the    Warrant
                                                     Certificate.)
                                            
                                                (Insert Social Security or Other
                                                   Identifying Number of Holder)


                                      E-70

<PAGE>




                                                                       EXHIBIT 5













                                      E-71

<PAGE>





                                                                  April 30, 1997


Pharmos Corporation
2 Innovation Drive
Alachua, FL 32615

Ladies and Gentlemen:

We have  examined  the  Registration  Statement  on Form S-3 (the  "Registration
Statement") to be filed by you with the  Securities  and Exchange  Commission in
connection  with the offer of certain  selling  stockholders  named therein (the
"Selling  Stockholders")  to sell from time to time up to 10,000,000 shares (the
"Shares") of the Common Stock, par value $.03 per share, of Pharmos  Corporation
(the "Company") upon conversion of the Preferred Stock issued in connection with
the March  31,  1997  private  placement  transaction  (the  "Private  Placement
Transaction")  and up to  159,000  shares of the  Company's  Common  Stock  (the
"Warrant  Shares")  issuable  upon the  exercise of certain  warrants  issued in
connection with the Private  Placement  Transaction  (the  "Warrants").  As your
counsel in connection with the Private  Placement  Transaction and the offer and
sale of the  Shares and the  issuance  of the  Warrants,  we have  examined  the
originals,  or photostatic or certified  copies, of such records of the Company,
certificates  of the Company and of public  officials and such other matters and
documents as we have deemed necessary or relevant as a basis for this opinion.

Based on these  examinations,  it is our opinion that the Shares and the Warrant
Shares,  when issued upon payment therefor,  will be validly issued,  fully paid
and non-assessable shares of Common Stock of the Company.

We  consent  to the  use of  this  opinion  as an  exhibit  to the  Registration
Statement  and further  consent to the  reference to this firm under the caption
"Legal Opinions" in the Prospectus forming a part of the Registration Statement.


         Very truly yours,

         EILENBERG & ZIVIAN
         /s/Eilenberg & Zivian
         ---------------------------



                                      E-72

<PAGE>




                                                                   EXHIBIT 23(b)













                                      E-73

<PAGE>


                       CONSENT OF INDEPENDENT ACCOUNTANTS


To the Board of Directors and
Shareholders of Pharmos Corporation

We  hereby  consent  to  the   incorporation  by  reference  in  the  Prospectus
constituting part of this Registration Statement on Form S-3 of our report dated
March 31, 1997 appearing in Pharmos Corporation's Annual Report on Form 10-K for
the year ended  December 31, 1996.  We also consent to the reference to us under
the heading "Experts" in such Prospectus.



/s/PRICE WATERHOUSE LLP
- --------------------------
PRICE WATERHOUSE LLP
New York, New York
April 29, 1997




                                      E-74


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission