PHARMOS CORP
S-3, 1998-03-05
PHARMACEUTICAL PREPARATIONS
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      As filed with the Securities and Exchange Commission on March 5, 1998

                                                  Registration No. 333-_________
- --------------------------------------------------------------------------------


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                      ------------------------------------



                                    FORM S-3
                             REGISTRATION STATEMENT
                  UNDER THE SECURITIES ACT OF 1933, AS AMENDED

                      ------------------------------------


                               PHARMOS CORPORATION
             (Exact name of registrant as specified in its charter)

              Nevada                                    36-3207413
   (State or other jurisdiction             (I.R.S. Employer Identification No.)
of incorporation or organization)

                         33 Wood Avenue South, Suite 466
                            Iselin, New Jersey 08830
                                 (732) 603-3526
          (Address, including zip code, and telephone number, including
            area code, of registrant's principal executive offices)

                      ------------------------------------


                                 GAD RIESENFELD
                         33 Wood Avenue South, Suite 466
                            Iselin, New Jersey 08830
                                 (732) 603-3526
                (Name, address, including zip code, and telephone
               number, including area code, of agent for service)

                      ------------------------------------


                                   Copies to:
                             ADAM D. EILENBERG, ESQ.
                    Ehrenreich Eilenberg Krause & Zivian LLP
                         11 East 44th Street, 17th Floor
                            New York, New York 10017

                      ------------------------------------


     Approximate  date of  commencement  of proposed sale to public:  As soon as
practicable after the effective date of the registration statement

     If the only  securities  being  registered  on this Form are being  offered
pursuant to dividend or interest  reinvestment plans, please check the following
box. |_|

     If any of the securities being registered on this Form are to be offered on
a delayed or continuous  basis  pursuant to Rule 415 under the Securities Act of
1933,  other than  securities  offered in  connection  with dividend or interest
reinvestment plans, check the following box. | X |


<PAGE>

                                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
                                                        Proposed           Proposed
                                                        Maximum            Maximum            Amount of
Title of Each Class of               Amount to be       Offering Price     Aggregate          Registration
Securities to be Registered          Registered         Per Unit           Price              Fee
- -----------------------------------------------------------------------------------------------------------------
<S>                                  <C>                    <C>             <C>                  <C>      
Shares of Common stock to be         9,050,000(1)           $2.22(3)        $20,091,000          $5,926.85
sold by Selling Security holder
Shares of Common Stock                 800,000(2)              $2.67         $2,136,000            $630.12
issuable upon exercise of
Warrants to purchase 800,000
Shares at $2.67 per share
- -----------------------------------------------------------------------------------------------------------------
Shares of Common Stock                 150,000(2)              $2.28           $342,000            $100.89
issuable upon exercise of
Warrants to purchase 150,000
Shares at $2.28 per share
- -----------------------------------------------------------------------------------------------------------------
Shares of Common Stock                 171,052(2)              $1.38           $236,052             $69.64
issuable upon exercise of
Warrants to purchase 171,052
Shares at $1.38 per share
- -----------------------------------------------------------------------------------------------------------------
Total Registration Fee                                                      $22,805,052             $6,728
</TABLE>

(1)  Assumes  conversion  price for all the preferred  stock at $0.88,  which is
     estimated for the purpose of  determining  the maximum  number of shares of
     Common Stock obtained upon conversion.

(2)  Pursuant to Rule 416 under the  Securities  Act of 1933,  an  indeterminate
     number of  additional  shares of common stock as may become  issuable  upon
     conversion of the  preferred  stock and the exercise of the Warrants (i) to
     prevent  dilution  resulting from stock splits,  stock dividends or similar
     transaction,  or (ii) by reason of changes in the  conversion  price of the
     preferred  stock or the exercise  price of the Warrants in accordance  with
     the terms thereof, as the case may be.

(3)  Estimated  solely for the  purpose of  calculating  the  registration  fee.
     Proposed  maximum  offering  price per share is  estimated  based  upon the
     closing price of the Company's  Common Stock listed on the Nasdaq  SmallCap
     Market on March 2, 1998.


     The  registrant  hereby amends the  registration  statement on such date or
dates as may be necessary to delay its effective date until the registrant shall
file a further  amendment  which  specifically  states  that  this  registration
statement shall  thereafter  become effective in accordance with Section 8(a) of
the  Securities  Act of 1933 or until the  registration  statement  shall become
effective on such date as the Commission,  acting pursuant to said Section 8(a),
may determine.


<PAGE>


                               PHARMOS CORPORATION

Cross  Reference  Sheet Showing  Location in Prospectus of Information  Required
Therein by Item 1 through 13 of Form S-3

      Registration Statement                             Prospectus Caption
          Item and Heading                                  of Location
          ----------------                                  -----------

  1.  Forepart of the Registration
      Statement and Outside Front
      Cover Page of Prospectus ......................  Outside Front Cover
                                                       
  2.  Inside Front and Outside Back                    
      Cover Pages and Prospectus.....................  Inside Front Cover Page
                                                       
  3.  Summary Information,                             
      Prospectus Summary                               
      and Ratio of Earnings to                         Outside Front Cover,
      Fixed Charges..................................  Risk Factors
                                                       
  4.  Use of Proceeds................................  Use of Proceeds
                                                       
  5.  Determination of Offering Price................  Cover Page
                                                       
  6.  Dilution.......................................  Dilution
                                                       
  7.  Selling Security Holder........................  Selling Security Holder
                                                       
  8.  Plan of Distribution...........................  Cover Page, Plan of 
                                                       Distribution
                                                       
  9.  Description of the Securities to                 
      be Registered..................................  Description of Securities
                                                       
 10.  Interest of Named Experts and Counsel..........  Experts
                                                       
 11.  Material Changes...............................  Recent Developments
                                                       
 12.  Incorporation of Certain                         
      Information by Reference.......................  Incorporation of Certain
                                                       Documents by Reference
                                                       
 13.  Disclosure of Commission Position                
      on Indemnification for Securities                
      Act Liabilities................................  Commission's Policy on
                                                       Indemnification for 
                                                       Securities Act
                                                       Liabilities
                                                       
                                                                         
<PAGE>                                                                   
                                                                         
                                                                       

                               PHARMOS CORPORATION
                               -------------------

                        9,050,000 SHARES OF COMMON STOCK,
                          $.03 PAR VALUE, TO BE SOLD BY
                             SELLING SECURITY HOLDER

                     800,000 SHARES OF COMMON STOCK ISSUABLE
                  UPON EXERCISE OF WARRANTS TO PURCHASE SHARES
                     AT AN EXERCISE PRICE OF $2.67 PER SHARE

                     150,000 SHARES OF COMMON STOCK ISSUABLE
                  UPON EXERCISE OF WARRANTS TO PURCHASE SHARES
                     AT AN EXERCISE PRICE OF $2.28 PER SHARE

                     171,052 SHARES OF COMMON STOCK ISSUABLE
                  UPON EXERCISE OF WARRANTS TO PURCHASE SHARES
                     AT AN EXERCISE PRICE OF $1.38 PER SHARE


     This  Prospectus  covers the  proposed  offer and resale of up to 9,050,000
shares  (the  "Shares"),  the  amount  of which is  calculated  based on a $0.88
conversion  price, of common stock,  par value $.03 ("Common  Stock") of Pharmos
Corporation (the "Company") held by the stockholder (the "Selling  Stockholder")
who purchased 5,000 shares  ($5,000,000  principal amount) of 5% Preferred Stock
(the  "Series C  Preferred  Stock")  convertible  into such  shares in a private
placement  transaction in February 1998 (the "Private  Placement  Transaction").
The Private Placement  Transaction,  in which the Company issued 5,000 shares of
Series C Preferred Stock to the Selling  Stockholder for the principal amount of
$5,000,000,  and  has  the  option  to sell  to the  Selling  Stockholder  3,000
additional  shares for the principal  amount of $3,000,000 of Series C Preferred
Stock convertible into shares of Common Stock, was completed on February 4, 1998
(the "Closing Date").

     This  Prospectus  also covers the offer and proposed sale by the Company of
up to (i)  800,000  shares of Common  Stock  issuable  upon the  exercise by the
holders  thereof of warrants to purchase  800,000 shares at an exercise price of
$2.67 per share issued to the Selling Stockholder in connection with the Private
Placement  Transaction;  (ii) 150,000  shares of Common Stock  issuable upon the
exercise by the holders  thereof of  warrants to purchase  150,000  shares at an
exercise  price of  $2.28  per  share  issued  to the  placement  agent  and its
assignees  in  connection  with the  Private  Placement  Transaction;  and (iii)
171,052 shares of Common Stock issuable upon the exercise by the holders thereof
of warrants to purchase  171,052  shares at an exercise price of $1.38 per share
issued in connection  with a private  placement  transaction  in April 1997 (the
"1997 Private Placement Transaction").  All of these amounts may increase solely
to  account  for  applicable  anti-dilution  adjustments,  if  any.  (All of the
warrants set forth above are hereinafter separately and collectively referred to
as the  "Warrants"  and the shares of Common Stock issuable upon the exercise of
the Warrants are  hereinafter  separately  and  collectively  referred to as the
"Warrant Shares.")


<PAGE>


     In  connection  with this  offering,  the Selling  Stockholder  and certain
holders of the Warrants who may be deemed to be "affiliates" of the Company,  as
that term is defined under the  Securities  Act of 1933, as amended (the "Act"),
may be deemed to be an  "underwriter," as that term is defined under the Act, of
the Shares or Warrant Shares offered hereby.  It is anticipated that the Selling
Stockholder  and such  affiliates  intend to sell the Shares or  Warrant  Shares
offered hereby from time to time for their own  respective  accounts in the open
market  at  the  prices  prevailing   therein  or  in  individually   negotiated
transactions at such prices as may be agreed upon. Each Selling  Stockholder and
such affiliate will bear all expenses with respect to the offering of the Shares
or Warrant  Shares  offered  hereby by him except the costs of legal counsel and
costs  associated with  registering  such shares under the Act and preparing and
printing this Prospectus.

     The net proceeds from Shares to be sold by the Selling  Stockholder (and by
holders of Warrant  Shares who exercise  their  Warrants) will inure entirely to
their  benefit and not to that of the Company;  however the Company will receive
proceeds from the exercise of the Warrants.

     The Company's Common Stock is traded on the over-the-counter  market and is
quoted on the Nasdaq  SmallCap  Market under the symbol "PARS" The closing price
of the Company's Common Stock on March 2, 1998 was $2.2188



<PAGE>


THESE  SECURITIES  INVOLVE A HIGH  DEGREE OF RISK AND  SUBSTANTIAL  DILUTION  AS
DESCRIBED HEREIN (SEE "RISK FACTORS" AND "DILUTION").

THESE  SECURITIES  HAVE NOT BEEN APPROVED OR  DISAPPROVED  BY THE SECURITIES AND
EXCHANGE  COMMISSION OR ANY STATE  SECURITIES  COMMISSION NOR HAS THE SECURITIES
AND  EXCHANGE  COMMISSION  OR ANY STATE  SECURITIES  COMMISSION  PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.


            The date of this Prospectus is _________________________



<PAGE>


     The  Company  will  furnish  to each  person  to whom  this  Prospectus  is
delivered,  upon written request, a copy of any or all of the documents referred
to by reference,  other than exhibits to such documents unless such exhibits are
specifically incorporated herein by reference.  Requests should be addressed to:
Mr. Gad Riesenfeld,  President and Chief Operating Officer, Pharmos Corporation,
33 Wood Avenue South, Suite 466, Iselin, New Jersey 08830.


<PAGE>


     NO  DEALER,  SALESMAN  OR  OTHER  PERSON  HAS BEEN  AUTHORIZED  TO GIVE ANY
INFORMATION  OR TO MAKE ANY  REPRESENTATION  OTHER THAN THOSE  CONTAINED IN THIS
PROSPECTUS.  ANY INFORMATION OR REPRESENTATION NOT HEREIN CONTAINED, IF GIVEN OR
MADE,  MUST NOT BE RELIED UPON AS HAVING BEEN  AUTHORIZED  BY THE COMPANY.  THIS
PROSPECTUS  DOES NOT  CONSTITUTE  AN OFFER OR  SOLICITATION  IN  RESPECT  OF THE
SECURITIES  IN ANY  JURISDICTION  IN WHICH SUCH OFFER OR  SOLICITATION  WOULD BE
UNLAWFUL. DELIVERY OF THIS PROSPECTUS SHALL NOT, UNDER ANY CIRCUMSTANCES, CREATE
ANY  IMPLICATION  THAT THERE HAS BEEN NO CHANGE IN THE  AFFAIRS  OF THE  COMPANY
SINCE THE DATE OF THIS PROSPECTUS.


<PAGE>


                             ADDITIONAL INFORMATION

     The Company has filed with the  Securities  and  Exchange  Commission,  450
Fifth Street, Washington, D.C. 20549, a Registration Statement on Form S-3 under
the Securities Act of 1933 with respect to the securities  offered hereby.  This
Prospectus filed as part of such Registration Statement does not contain all the
information set forth in, or annexed as exhibits to, the Registration Statement.
For further  information  pertaining to the  securities  offered  hereby and the
Company,  reference  is  made to the  Registration  Statement  and the  exhibits
thereto. The Registration Statement and exhibits thereto may be inspected at the
Headquarters  Office of the  Securities and Exchange  Commission  located at 450
Fifth Street,  N.W.,  Room 1024,  Washington,  D.C.  20549 and at certain of the
Commission's regional offices at the following addresses:  7 World Trade Center,
Suite 1300, New York, New York 10048;  Northwest Atrium Center, 500 West Madison
Street,  Suite 1400,  Chicago,  IL 60661.  Copies of this  material  also may be
obtained  from the Public  Reference  Section of the SEC,  at 450 Fifth  Street,
N.W., Room 1024, Washington,  D.C. at prescribed rates.  Electronic registration
statements made through the Electronic  Data  Gathering,  Analysis and Retrieval
System are publicly  available  through the Commission's  World Wide Web site at
http:\www.sec.gov.  The statements  contained in this Prospectus  concerning the
contents of any contract or document  referred to are not necessarily  complete,
and in each instance, reference is made to such contract or document filed as an
exhibit to the  Registration  Statement,  each statement  being qualified in all
respects by provisions  of such exhibit to which  reference is hereby made for a
full statement of the provisions thereof.




<PAGE>


                                   THE COMPANY

     The Company is engaged in the development of novel pharmaceuticals based on
innovative drug design technologies  targeting diseases of the eye,  principally
ocular inflammation, and the brain, principally stroke and head trauma.

     Its  leading  products  are  (i)  Lotemax(TM),   a  proprietary  ophthalmic
anti-inflammatory drug that has demonstrated significant efficacy in a series of
completed  Phase III  clinical  trials and a uniquely  superior  safety  profile
compared to currently  available  ophthalmic  steroids;  and (ii)  Alrex(TM),  a
product with the same active  ingredient  as  Lotemax(TM) , for the treatment of
seasonal  allergic  conjunctivitis.  The  Company  has  submitted  its New  Drug
Applications  ("NDA's") for  Lotemax(TM) and Alrex(TM) to the U.S. Food and Drug
Administration ("FDA").

     The  Company's  principal  executive  offices are located at 33 Wood Avenue
South, Suite 466, Iselin, New Jersey 08830.

                                  RISK FACTORS

     The Common  Stock  being  offered  hereby  involves a high  degree of risk.
Prospective  investors should  carefully  consider the following risk factors in
addition to other  information  contained in this  Prospectus,  in evaluating an
investment in the shares of Common Stock offered hereby.

Early Stage of Development; Technological Uncertainty

     The Company is at an early stage of development. Apart from Lotemax(TM) and
Alrex(TM),  most of the  Company's  other  potential  products  are early in the
research and development  phase,  and product  revenues may not be realized from
the sale of any such  products for at least the next several  years,  if at all.
Many of the  Company's  proposed  products will require  significant  additional
research  and  development  efforts  prior  to  any  commercial  use,  including
extensive  preclinical  and  clinical  testing  as  well as  lengthy  regulatory
approval.  There can be no assurance that the Company's research and development
efforts will be successful,  that the Company's potential products will prove to
be safe and  effective in clinical  trials or that any  commercially  successful
products will ultimately be developed by the Company.

History of Operating Losses; Accumulated Deficit

     The  Company  has  experienced   significant  operating  losses  since  its
inception.  As of September 30, 1997, the Company had an accumulated  deficit of
approximately $70,177,875 million. The Company expects to incur operating losses
over at least the next several years as the Company's  research and  development
efforts and preclinical and clinical testing activities continue.  The Company's
ability to achieve profitability depends in part upon its ability, alone or with
others, to successfully commercialize and receive approval on its first proposed
product, to

                                        1

<PAGE>


complete  development  of  its  other  proposed  products,  to  obtain  required
regulatory approvals and to manufacture and market such products.

Future Capital Needs; Uncertainty of Additional Financing

     The Company's operations to date have consumed substantial amounts of cash.
The development of the Company's  technology and potential products will require
a  commitment  of  substantial  funds to conduct  the costly and  time-consuming
research necessary to develop and optimize such technology,  and ultimately,  to
establish manufacturing and marketing capabilities. The Company's future capital
requirements  will  depend  on  many  factors,  including  continued  scientific
progress in the research and  development  of the Company's  technology and drug
programs,  the ability of the Company to establish  and  maintain  collaborative
arrangements  with others for drug  development,  progress with  preclinical and
clinical trials, the time and costs involved in obtaining regulatory  approvals,
the costs involved in preparing, filing, prosecuting,  maintaining and enforcing
patent claims,  competing technological and market developments,  changes in its
existing  research   relationships   and  effective  product   commercialization
activities and arrangements.

     The Company  believes that its current cash  resources and interest  income
thereon,  including approximately $4.75 million in net cash and cash equivalents
received  by the  Company  from the  Private  Placement  Transaction,  should be
sufficient to fund its operating expenses and capital  requirements as currently
planned  through the first  quarter of 1999.  The Company  will seek  additional
funding through  collaborative  arrangements or through future public or private
equity or debt financing.  There can be no assurance that  additional  financing
will be available on acceptable  terms, or at all. In addition,  pursuant to the
Private  Placement  Transaction,  the Company  will not,  except  under  certain
limited  exceptions,  issue or agree to issue any equity  securities  at a price
less than fair market value or any variably priced  securities  convertible into
or  exercisable  or  exchangeable  for equity or equity like  securities  of the
Company  for a period of one hundred  eighty  (180) days  following  the Closing
Date.  If  additional  funds are raised by issuing  equity  securities,  further
dilution to stockholders  may result.  If adequate funds are not available,  the
Company may be required to delay,  reduce the scope of or eliminate  one or more
of its research or development  programs or to obtain funds through arrangements
with collaborative partners or others that may require the Company to relinquish
rights to certain of its technologies,  product  candidates or products that the
Company would otherwise seek to develop or commercialize itself.

Dependence on Potential Collaborative Partners

     The   Company's   strategy   for   the   development,   clinical   testing,
manufacturing,  marketing  and  commercialization  of  certain  of its  products
includes  entering  into  various   collaborations   with  corporate   partners,
licensors,  licensees  and  others.  To  date,  the  Company  has  entered  into
agreements  with  Bausch & Lomb to  manufacture  and market the  Company's  lead
products, Lotemax(TM) and Alrex(TM), in the United States and throughout Europe,
Canada  and  selected   other   countries.   The   agreements   also  cover  the
co-development  of  LE-T,  a  combination  of  loteprednol   etabonate  and  the
anti-infective tobromycn, that is currently being developed by the Company.

                                        2

<PAGE>


There can be no assurance  that the Company will be able to negotiate any future
collaborative  agreement  with Bausch & Lomb or other  companies  on  acceptable
terms,  or  that  any  present  or  future  collaborative   agreements  will  be
successful.  To the extent  that the  Company  chooses  not to or is not able to
establish such  arrangements,  the Company would  experience  increased  capital
requirements to undertake such activities at its own expense.  In addition,  the
Company may encounter  significant  delays in introducing its proposed  products
currently under  development  into certain markets or find that the development,
manufacture,  or sale of its  proposed  products  in such  markets is  adversely
affected by the absence of such collaborative agreements.

Technological Change and Competition

     The  pharmaceutical  industry  is  subject  to  rapid,   unpredictable  and
significant  technological  change.  Competition  from  universities,   research
institutions and other pharmaceutical,  chemical and biotechnology  companies is
intense.  Many  competitors  or potential  competitors  have  greater  financial
resources,   research  and  development  capabilities,   and  manufacturing  and
marketing experience than the Company. To this end, the Company has entered into
agreements  with Bausch & Lomb for the  manufacture and marketing of Lotemax(TM)
and  Alrex(TM).  There can be no assurance  that  developments  by the Company's
competitors or potential competitors will not render the Company's technology or
proposed applications of its technology obsolete.

Technologies Subject to Licenses

     As a licensee  of certain  research  technologies,  the Company has various
license  agreements with certain U.S.  federal agencies and the State of Israel,
certain  universities  and Dr.  Nicholas  Bodor,  a former  vice  president  and
director  of the  Company,  wherein  the  Company  has  acquired  exclusive  and
coexclusive rights to develop and commercialize  certain research  technologies.
The  agreements  generally  require  the  Company  to pay  royalties  on sale of
products  developed  from the licensed  technologies  and fees on revenues  from
sublicensees,  where applicable, and the Company is responsible for the costs of
filing and prosecuting patent applications.  In addition,  some of the Company's
license  agreements  require that the Company  commit  certain sums annually for
research and development of the licensed products.

     The exclusivity of license agreements generally expires fifteen years after
the  later  of  commercialization  or the  effectiveness  of the  patents.  Each
agreement  is  terminable  by either  party,  upon  notice,  if the other  party
defaults in its obligations.

Uncertainty of Protection of Patents and Proprietary Rights

     The  Company's  success  will depend in large part on its ability to obtain
patents,   maintain  trade  secrets  and  operate  without   infringing  on  the
proprietary  rights of  others,  both in the U.S.  and in other  countries.  The
patent positions of pharmaceutical companies can be highly uncertain and involve
complex   legal  and  factual   questions,   and   therefore   the  breadth  and
enforceability of claims allowed in pharmaceutical  patents cannot be predicted.
There  can be no  assurance  that any  issued  or  pending  patents  will not be
challenged, invalidated or circumvented, or that the rights

                                        3

<PAGE>



granted thereunder will provide proprietary protection or competitive advantages
to the Company.

     The commercial success of the Company also will depend, in part, on Pharmos
not  infringing  patents  issued  to others  and not  breaching  the  technology
licenses upon which any Company products are based. It is uncertain  whether any
third-party patents will require the Company to alter its products or processes,
obtain licenses or cease certain activities.  In addition, if patents are issued
to others which contain  competitive or conflicting  claims, and such claims are
ultimately  determined  to be  valid,  the  Company  may be  required  to obtain
licenses to these patents or to develop or obtain alternative technology. If any
licenses are required,  there can be no assurance  that the Company will be able
to obtain any such  licenses on  commercially  favorable  terms,  if at all. The
Company's  breach of an  existing  license or failure to obtain a license to any
technology that it may require to commercialize its products may have a material
adverse  impact on the Company.  Litigation,  which could result in  substantial
costs to the Company,  may also be necessary to enforce any patents  licensed or
issued to the Company or to  determine  the scope and  validity  of  third-party
proprietary  rights.  If  competitors  of the  Company  prepare  and file patent
applications in the U.S. that claim technology also claimed by the Company,  the
Company may have to participate in interference proceedings declared by the U.S.
Patent and  Trademark  Office to determine  priority of  invention,  which could
result in  substantial  costs to the Company,  even if the  eventual  outcome is
favorable  to the  Company.  An adverse  outcome  could  subject  the Company to
significant liabilities to third parties, require disputed rights to be licensed
from third parties or require the Company to cease using such technology.

     The Company  also relies on secrecy to protect its  technology,  especially
where patent  protection is not believed to be appropriate or obtainable.  Thus,
Pharmos  protects  its  proprietary  technology  and  processes,   in  part,  by
confidentiality   agreements   with  its  employees,   consultants  and  certain
contractors.  There  can be no  assurance  that  these  agreements  will  not be
breached,  that the Company would have adequate remedies for any breach, or that
the Company's trade secrets will not otherwise  become known or be independently
discovered by competitors.

Legal Proceedings and Disputes

     There are  currently  no  material  legal  proceedings  pending  against or
involving the Company.

Extensive Government Regulation

     The Company's  products  require the approval of the FDA before they can be
marketed  in the U.S.  In  addition,  approvals  are also  required  from health
authorities  in most  foreign  countries  before the  Company's  products can be
marketed in such  countries.  Before an NDA, a type of submission used to obtain
FDA  approval  to market a new drug,  can be filed with the FDA, a product  must
undergo, among other things, extensive animal testing and human clinical trials,
which  can take up to seven  years  to  complete.  Except  for  Lotemax(TM)  and
Alrex(TM), the Company has not yet filed NDAs on its products. The time required
for regulatory approval of the Company's products after acceptance for filing an
NDA can vary and is usually one to three years or more,  and the FDA may require
additional animal studies and/or clinical trials before granting

                                        4

<PAGE>



approval. There can be no assurance that the FDA and foreign regulatory agencies
will be satisfied with the  information,  including that emanating from clinical
trials,  submitted to them in applications (like NDAs) seeking approval and will
approve  the  marketing  of any of the  Company's  potential  products,  or that
problems will not arise that could delay or prevent the commercialization of the
Company's future products.

     There can be no  assurance  that any  potential  products  developed by the
Company  alone or in  conjunction  with  others  will be  proven  to be safe and
effective  in  clinical  trials and will meet all of the  applicable  regulatory
requirements   needed  to  receive  marketing   approval.   Data  obtained  from
preclinical   testing  and  clinical   trials  can  be  susceptible  to  varying
interpretations  which could delay,  limit or prevent regulatory  approvals.  In
addition,  delays or  disapprovals  may be  encountered  based  upon  additional
government regulation resulting from future legislation or administrative action
or changes in FDA policy made during the period of product  development  and FDA
regulatory review.  Similar delays may also be encountered in foreign countries.
There can be no assurance that even after such time and expenditures, regulatory
approval will be obtained for any potential  products  developed by the Company.
If regulatory approval of a product is granted, such approval will be limited to
those  therapeutic  uses for which the  product  has been  demonstrated  through
clinical studies and other means to be safe and effective. Furthermore, approval
may entail ongoing requirements for post-marketing  studies.  Even if regulatory
approval is obtained, a marketed product, its manufacturer and its manufacturing
facilities  are  subject to  continual  review  and  periodic  inspections.  The
regulatory  standards for manufacturing are currently being applied  stringently
by  the  FDA.   Discovery  of  previously   unknown  problems  with  a  product,
manufacturer  or facility  may result in FDA  restrictions  being placed on such
product or manufacturer  or facility,  including an order to withdraw a specific
product from the market, and may also result in court enforced sanctions against
the product, manufacturer or facility.

     The Company may establish  collaborative  relationships to conduct clinical
testing and seek  regulatory  approvals to market its products in major  markets
outside the U.S.  There can be no assurance  that the Company will be successful
in establishing such  relationships or that such approvals will be received in a
timely  manner,  if at all. To market its products  abroad,  the Company is also
subject to numerous and varying foreign regulatory requirements,  implemented by
foreign health  authorities,  governing the design and conduct of human clinical
trials, pricing and marketing. The approval procedure varies among countries and
can involve  additional  testing,  and the time required to obtain  approval may
differ from that required to obtain FDA approval. At present,  foreign marketing
authorizations are applied for at a national level, although within the European
Union ("EU") certain registration  procedures are available to companies wishing
to  market  a  product  in more  than one EU  member  country.  If a  regulatory
authority is satisfied  that adequate  evidence of safety,  quality and efficacy
has been  presented,  marketing  authorization  is almost  always  granted.  The
foreign  regulatory  approval  process includes all of the risks associated with
obtaining  FDA  approval  set forth  above.  Approval by the FDA does not ensure
approval by other countries.

Lack of Sales and Marketing Capability


                                        5

<PAGE>


     The Company has no  experience  in sales,  marketing  or  distribution.  To
market any of its products directly,  the Company must develop a marketing force
and sales  force  with  technical  expertise  and with  supporting  distribution
capability.   Alternatively,   the  Company  may  obtain  the  assistance  of  a
pharmaceutical company with an established  distribution system and sales force.
The Company has entered into agreements with Bausch & Lomb to market Lotemax(TM)
Alrex(TM). There can be no assurance,  however, that the Company will be able to
establish sales and distribution capabilities or be successful in gaining market
acceptance for its products.

Lack of Manufacturing Capability

     The Company currently does not have manufacturing facilities to produce its
products  for  clinical  trials.  The  Company's  agreements  with Bausch & Lomb
provide  for the  manufacturing  of  Lotemax(TM)  and  Alrex(TM).  The  proposed
products  under  development  by the Company have never been  manufactured  on a
commercial  scale and  there can be no  assurances  that  such  products  can be
manufactured  at a cost or in  quantities  necessary  to make them  commercially
viable.  Any  delay in  availability  of  products  may  result  in delay in the
submission of products for regulatory  approval or the market  introduction  and
subsequent sales of such products, which would have a material adverse effect on
the Company.

Need to Attract and Retain Key Employees and Consultants

     The Company is highly dependent on the principal  members of its scientific
and  management  staff.  In  addition,  the Company  relies on  consultants  and
advisors to assist the  Company in  formulating  its  research  and  development
strategy. Retaining and attracting qualified personnel, consultants and advisors
will be  critical  to the  Company's  success.  In order to pursue  its  product
development and marketing plans, the Company will be required to hire additional
qualified scientific  personnel to perform research and development,  as well as
personnel   with   expertise  in  clinical   testing,   government   regulation,
manufacturing  and  marketing.  The  Company  faces  competition  for  qualified
individuals   from  numerous   pharmaceutical   and   biotechnology   companies,
universities and other research institutions. There can be no assurance that the
Company will be able to attract and retain such  individuals on acceptable terms
or at all.

     The Company's  clinical  development  is conducted  under  agreements  with
universities and medical  institutions.  The Company depends on the availability
of a principal investigator for each such program, and the Company cannot assure
that these  individuals  or their  research  staffs will be available to conduct
clinical development.  The Company's academic collaborators are not employees of
the Company.  As a result, the Company has limited control over their activities
and can expect  that only  limited  amounts of their time will be  dedicated  to
Company activities.  The Company's academic collaborators may have relationships
with other commercial entities, some of which compete with the Company.


                                        6

<PAGE>



Uncertainty of Health Care Reform Measures and Third-Party Reimbursement

     The  levels  of   revenues   and   profitability   of   biotechnology   and
pharmaceutical   companies  may  be  affected  by  the  continuing   efforts  of
governmental  and  third-party  payors to  contain or reduce the costs of health
care through various means. For example, in certain foreign markets,  pricing or
profitability of prescription  pharmaceuticals is subject to government control.
In the U.S.,  there have been, and the Company  expects that there will continue
to be, a number of federal  and state  proposals  to control  health care costs.
While the Company  cannot  predict  whether any such  legislative  or regulatory
proposals will be adopted or the effect such proposals may have on its business,
the uncertainty  surrounding such proposals could have a material adverse effect
on  the  Company.  Furthermore,  the  Company's  ability  to  commercialize  its
potential  product  portfolio may be adversely  affected to the extent that such
proposals have a material  adverse effect on the business,  financial  condition
and  profitability  of other  companies that are prospective  collaborators  for
certain of the Company's proposed products.

Dependence on Reimbursement

     Pharmos' ability to commercialize  its products  successfully may depend in
part on the  extent to which  reimbursement  for the cost of such  products  and
related  treatments  will be available  from  government  health  administration
authorities, private health insurers and other organizations. Third-party payors
are  increasingly  challenging  the  price of  medical  products  and  services.
Significant  uncertainty exists as to the reimbursement status of newly approved
health care products,  and there can be no assurance  that adequate  third-party
coverage will be available to enable Pharmos to maintain price levels sufficient
to realize an appropriate return on its investment in product development.

Risk of Product Liability; Availability of Insurance

     The design,  development and manufacture of the Company's  products involve
an inherent risk of product liability claims and associated  adverse  publicity.
Although the Company currently maintains general liability insurance,  there can
be no assurance  that the coverage  limits of the Company's  insurance  policies
will be adequate.  Similarly,  the Company  currently  maintains  clinical trial
liability  insurance,  but there can be no assurance  that the coverage limit of
the Company's insurance policies will be adequate.  The Company currently has no
product liability insurance, and there can be no assurance that the Company will
be able to obtain or maintain product liability insurance on acceptable terms or
with  adequate  coverage  against  potential  liabilities.   Such  insurance  is
expensive,  difficult  to  obtain  and may not be  available  in the  future  on
acceptable  terms or at all. A successful  claim brought  against the Company in
excess of the Company's  insurance coverage could have a material adverse effect
upon the Company and its financial condition.

Use of Hazardous  Materials;  Potential  Liability to Comply with  Environmental
Laws

     The  Company's  research and  development  involves the  controlled  use of
hazardous  materials.  Although the Company believes that its safety  procedures
for handling and disposing

                                        7

<PAGE>


of such materials comply in all material  respects with the standard  prescribed
by state and federal regulations, the risk of accidental contamination or injury
from these materials  cannot be completely  eliminated.  In the event of such an
accident,  the Company could be held liable for any damages that result, and any
such liability could exceed the resources of the Company.  The Company may incur
substantial  costs to  comply  with  environmental  regulations  if the  Company
develops manufacturing capacity.

Market for the Company's  Securities;  Shares Eligible for Future Sale; Possible
Volatility of Share Prices

     The market price of the Company's Common Stock, like that of other emerging
pharmaceutical  companies,  has fluctuated  significantly in recent years and is
likely to  fluctuate  in the  future.  Announcements  by the  Company  or others
regarding  scientific  discoveries,   technological   innovations,   litigation,
products,  patents or  proprietary  rights,  the  progress of  clinical  trials,
government  regulation,  public  concern  as to the  safety  of  drugs  and  the
reliability of the Company's testing processes and general market conditions may
have a significant  impact on the market price of the Common Stock. The addition
of the shares being offered hereby and the shares  issuable upon exercise of the
Company's  currently   outstanding   warrants  and  options  to  the  number  of
publicly-traded  shares of the Company's  Common Stock may affect the volatility
of share prices of the Company's Common Stock.

Outstanding Stock Options and Warrants

     As of  September  30, 1997,  the Company had  outstanding  incentive  stock
options to purchase an aggregate of 438,419 shares of Common Stock at an average
exercise price of $2.21 per share and non-qualified stock options to purchase an
aggregate of 407,182 at an average  exercise  price of $2.42 per share issued to
employees,  directors  and  consultants  pursuant  to  stock  option  plans  and
individual  agreements with management and directors of the Company and warrants
to purchase  4,629,129  shares of the Company's Common Stock at an average price
of $1.92 per share.

     The Company may issue additional capital stock,  warrants and/or options to
raise capital in the future.  The Company  regularly  examines  opportunities to
expand its  technology  base and product  line  through  means such as licenses,
joint  ventures and  acquisition  of assets or ongoing  businesses and may issue
securities in connection  with such  transactions.  However,  no  commitments to
enter  into or pursue  any such  transaction  have been made and there can be no
assurance that any such discussions  will result in any such  transaction  being
concluded.  In order to attract and retain key  personnel,  the Company may also
issue  additional  securities,  including stock options,  in connection with its
employee  benefit  plans.  During the terms of such  options and  warrants,  the
holders  thereof are given the  opportunity  to profit from a rise in the market
price of the Company's  Common Stock.  The exercise of such options and warrants
may have an adverse  effect on the market value of the  Company's  Common Stock.
Also, the existence of such options and warrants may adversely  affect the terms
on which the Company can obtain additional equity financing.


                                        8

<PAGE>


Anti-Takeover Provisions

     The  Company is  subject  to  Sections  78.411-.444  of the Nevada  General
Corporation  Law ("Nevada  Law"),  an  anti-takeover  law,  which may discourage
certain types of transactions involving an actual or potential change in control
of the Company, including transactions in which the stockholders might otherwise
receive a premium for their  shares over the current  prices,  and may limit the
ability of the stockholders to approve a transaction that they may deem to be in
their best  interests.  In addition,  the Board of Directors  has the  authority
without  action by the  stockholders  to fix the rights and  preferences  of and
issue  shares of  Preferred  Stock,  which may have the  effect of  delaying  or
preventing a change in control of the Company.

Potential Future Acquisitions

     Due to the  current  uncertainties  of the  capital  markets  for  emerging
pharmaceutical  companies,  the Company  has had  preliminary  discussions  with
several  emerging  pharmaceutical  and  biotechnology  companies about potential
business and/or product consolidations, joint ventures, acquisitions, mergers or
other  business  combinations  (collectively  "acquisitions").  In the event the
Company undertakes any such acquisitions it may use some of its cash,  including
part of the cash received in connection with the Private Placement  Transaction,
or may  issue its  stock in  connection  therewith.  Although  management  would
attempt to structure such  acquisitions in a manner that will minimize  dilution
of the equity  owned by current  stockholders,  no  assurance  can be given that
acquisitions  will not result in such  dilution  or that  control of the Company
will not be changed as a result of such  acquisitions.  Such acquisitions may be
negotiated or may be sought on an unsolicited basis and may involve  speculative
and risky  undertakings by the Company with increased risks to its stockholders.
Under Nevada law, acquisitions do not require shareholders' approval except when
accomplished  by merger or  consolidation.  The  Company  does not,  in general,
intend to submit  acquisitions  to  shareholder  vote except  where  required by
Nevada law. The Company has not entered into any  preliminary  undertaking  with
any third  parties  involving any  acquisitions  or other  business  combination
transactions.

Special Considerations of Doing Business in Israel

     A significant  part of the operations of the Company is conducted in Israel
through its wholly-owned  subsidiary,  Pharmos Limited ("Pharmos Ltd."),  and is
directly  affected by economic,  political  and military  conditions  there.  In
addition, Pharmos Ltd. has received certain funding from the Office of the Chief
Scientist of the Israel  Ministry of Industry and Trade (the "Chief  Scientist")
relating to its proprietary SubMicron Emulsion Technology and to Dexanabinol,  a
new chemical entity.  Such funding prohibits the transfer or license of know-how
and the  manufacture  of  resulting  products  outside  of  Israel  without  the
permission of the Chief Scientist.  Although it is the Company's belief that the
Chief Scientist does not unreasonably withhold this permission if the request is
based upon commercially  justified  circumstances and any royalty obligations to
the Chief  Scientist are  sufficiently  assured,  there can be no assurance that
such consent,  if  requested,  would be granted upon terms  satisfactory  to the
Company or granted at all.

Absence of Dividends

                                        9

<PAGE>


     No dividends  have been paid on the Common  Stock to date,  and the Company
does not expect to pay cash dividends in the foreseeable future.


                                    DILUTION

     As of September  30, 1997,  the net tangible  book value of the Company was
$1,032,955  or $0.03 per share.  Net tangible book value per share is determined
by dividing the net tangible book value  (tangible  assets less  liabilities) of
the Company by the number of shares of Common Stock outstanding at that date.

     If all of the 800,000  Warrants  exercisable  at an exercise price of $2.67
per share are  exercised,  (each of the Warrants  purchasing one share of Common
Stock),  there would be 34,763,613 shares of Common Stock outstanding with a net
tangible book value of $0.09 and the  purchasers of shares  through the exercise
of such  Warrants at such prices  would suffer  immediate  dilution to $2.58 per
share.

If all of the 150,000  Warrants  exercisable  at an exercise  price of $2.28 per
share  are  exercised,  (each of the  Warrants  purchasing  one  share of Common
Stock),  there would be 34,113,613 shares of Common Stock outstanding with a net
tangible book value of $0.04 and the  purchasers of shares  through the exercise
of such  Warrants at such prices  would suffer  immediate  dilution to $2.24 per
share.

If all of the 171,052  Warrants  exercisable  at an exercise  price of $1.38 per
share  are  exercised,  (each of the  Warrants  purchasing  one  share of Common
Stock),  there would be 34,134,665 shares of Common Stock outstanding with a net
tangible book value of $0.04 and the  purchasers of shares  through the exercise
of such  Warrants at such prices  would suffer  immediate  dilution to $1.34 per
share.

If all of the Warrants are exercised, (each of the Warrants purchasing one share
of Common Stock),  there would be 35,084,665  shares of Common Stock outstanding
with a net tangible book value of $0.11.  The  purchasers of shares  through the
exercise of such  Warrants at a price of $2.67 per share would suffer  immediate
dilution to $2.56 per share;  the  purchasers of shares  through the exercise of
such Warrants at a price of $2.28 per share would suffer  immediate  dilution to
$2.17 per share;  and the  purchasers  of shares  through  the  exercise of such
Warrants at a price of $1.38 per share would suffer immediate  dilution to $1.27
per share.

                                 USE OF PROCEEDS

     The Company will receive no proceeds  from the  9,050,000  shares of Common
Stock to be offered and resold by the Selling Stockholder.

     If all 1,112,052  Warrants whose  underlying  Common Stock is being offered
hereby are  exercised,  the gross proceeds to be received by the Company will be
$2,714,052  (assuming  that the  cashless  exercise  option  is not used for the
800,000  Warrants  exercisable  at an  exercise  price of $2.67 and the  150,000
Warrants exercisable at an exercise price of $2.28).

                                       10

<PAGE>


     The Company  believes that its current cash  resources and interest  income
thereon,  including the funds obtained from the Private  Placement  Transaction,
should be sufficient to fund its operating expenses and capital  requirements as
currently  planned  through the first quarter of 1999. The amounts and timing of
expenditures  for each  purpose  will depend on the  progress  of the  Company's
research and development programs, technological advances,  determinations as to
commercial potential,  the terms of any collaborative  arrangements entered into
by the Company for development and licensing,  regulatory  approvals,  and other
factors, many of which are beyond the Company's control.  Pending such uses, the
cash  received in  connection  with the Private  Placement  Transaction  will be
invested  in  short-term,   interest-bearing  investment  grade  securities  and
commercial paper.

                            DESCRIPTION OF SECURITIES

Common Stock

     The Common Stock being offered hereby (i) by the Selling Stockholder,  (ii)
by the Company upon the exercise of the Warrants,  and (iii) by any  "affiliate"
of the Company upon the resale of such Common Stock obtained from exercising the
Warrants is fully described in the Company's  Registration Statement on Form 8-A
dated January 30, 1984, filed pursuant to Section 12 of the Securities  Exchange
Act of 1934, as amended (the  "Exchange  Act").  See  "Incorporation  of Certain
Documents by Reference".

     The Company's  Restated Articles of Incorporation  currently  authorize the
issuance of up to 60,000,000  shares of Common Stock. As of March 2, 1998, there
are currently 36,193,652 shares outstanding.

Preferred Stock

     The Company's  Restated Articles of Incorporation  currently  authorize the
issuance  of up to  1,250,000  shares  of  Preferred  Stock.  Of the  authorized
Preferred Stock, no shares,  designated as Series A or Series B Preferred Stock,
are currently  outstanding.  In addition  5,000  shares,  designated as Series C
Preferred  Stock,  are currently  issued and outstanding and held by the Selling
Stockholder.  There  are an  additional  3,000  shares,  designated  as Series C
Preferred  Stock  which may be issued at the  discretion  of the  Company to the
current  Selling  Stockholder.  The  Series C  Preferred  Stock  was  issued  in
connection with the February 1998 Private  Placement  Transaction  (the "Private
Placement  Transaction").  Holders of Series C Preferred Stock have the right to
convert their shares as follows:  at 90% of the average of the lowest sale price
of the Common Stock for the five consecutive  trading days ending on the trading
day  immediately  preceding the Conversion for the first 6 months after closing;
thereafter,  the  conversion  price  will equal the lower of (i) 90% of the then
prevailing  market  prices,  as  determined  above,  or (ii) 120% of the average
closing  bid prices  for days  151-180  following  the  closing.  For a complete
description  of the  rights of  holders  of Series C  Preferred  Stock,  see the
Company's  Current  Report on Form 8-K,  including the exhibits  thereto,  dated
February 4, 1998.

Warrants

                                       11

<PAGE>


     The  800,000  Warrants  exercisable  at an  exercise  price  of  $2.67  are
exercisable  commencing  February 4, 1999 and expire on  February  4, 2003;  the
150,000  Warrants  exercisable  at an  exercise  price of $2.28 are  exercisable
commencing  February  4, 1999 and expire on  February  4, 2003;  and the 171,052
Warrants exercisable at an exercise price of $1.38 are exercisable commencing on
March 31,  1998 and  expire  on March  31,  2008.  All of the  Warrants  contain
anti-dilution  provisions  providing  for  an  adjustment  to  their  respective
exercise  prices in the event that the  Company  effects a stock  split or stock
dividend. In addition,  the number and kind of shares of Common Stock underlying
the  Warrants  are  subject  to   adjustments   in  the  event  of  any  capital
reorganization,  or  reclassification  of the capital  stock of the Company,  or
consolidation or merger of the Company with another corporation or entity (other
than a  subsidiary  of the  Company  in which the  Company is the  surviving  or
continuing corporation and no change occurs in the Company's Common Stock).

Other Securities--Preferred Stock

     The Company's  Restated Articles of Incorporation  currently  authorize the
issuance of up to  1,250,000  shares of Preferred  Stock,  of which no shares of
Series A or Series B Preferred Stock are currently outstanding, and 5,000 shares
of Series C Preferred  Stock  issued in  connection  with the Private  Placement
Transaction  are  currently  issued and  outstanding  as of March 2,  1998,  and
empower the Board of  Directors,  without  the  necessity  of further  action or
authorization by the stockholders,  to authorize the issuance of Preferred Stock
from  time  to  time  in one or more  series  and to fix  the  relative  rights,
preferences and limitations of each such series. The issuance of Preferred Stock
could  adversely  affect  the voting  power of  holders of Common  Stock and the
likelihood  that such holders will receive  dividend  payments and payments upon
liquidation  and could have the effect of delaying,  deferring  or  preventing a
change in control of the  Company.  The Company has no present plan to issue any
additional shares of Preferred Stock.

Other Securities--Options and Warrants

     As of  September  30, 1997,  the Company had  outstanding  incentive  stock
options to purchase an aggregate of 438,419 shares of Common Stock at an average
exercise price of $2.21 per share and non-qualified stock options to purchase an
aggregate of 407,182 at an average  exercise  price of $2.42 per share issued to
employees,  directors  and  consultants  pursuant  to  stock  option  plans  and
individual  agreements with management and directors of the Company and warrants
(excluding the Warrants) to purchase  4,629,129  shares of the Company's  Common
Stock at an average price of $1.92 per share,  consisting of:  266,835  warrants
which can be  exercised  until  March 1998 each to  purchase  a single  share of
Common Stock for $2.03; 309,741 warrants which can be exercised until March 1998
each to  purchase a single  share of Common  Stock for $2.53;  361,844  warrants
which can be  exercised  until  March 1998 each to  purchase  a single  share of
Common Stock for $1.52;  450,744  warrants  which can be exercised  until August
1998 each to purchase a single share of Common Stock for $2.69;  65,044 warrants
which can be exercised  until  September 1999 each to purchase a single share of
Common Stock for $2.26;  200,000  warrants which can be exercised  until October
1999 each to purchase a single share of Common Stock for $0.84; 500,000 warrants
which can be  exercised  until  April 2005 each to  purchase  a single  share of
Common Stock for $2.75;  10,000 Warrants which can be exercised until April 2005
each to

                                       12

<PAGE>



purchase a single share of Common Stock for $0.78;  15,000 warrants which can be
exercised  until April 2000 each to purchase a single  share of Common Stock for
$.75; 25,000 Warrants which can be exercised until April 2000 each to purchase a
single share of Common Stock for $1.00;  25,000  warrants which can be exercised
until  April  2000 each to  purchase a single  share of Common  Stock for $1.50;
862,500  warrants which can be exercised until September 2000 each to purchase a
single share of Common Stock for $1.80;  10,000  warrants which can be exercised
until  October  2001 each to purchase a single  share of Common Stock for $1.88;
15,000  warrants  which can be  exercised  until  March 2002 each to  purchase a
single share of Common Stock for $2.31;  65,000  warrants which can be exercised
until  September 2007 each to purchase a single share of Common Stock for $1.34;
50,000  warrants which can be exercised  until September 2007 each to purchase a
single share of Common Stock for $1.75;  159,000 warrants which can be exercised
until  March  2001  each  to  purchase  a  single  share  of  Common  Stock  for
$1.75;10,000  warrants  which can be exercised from November 1997 until November
2002 each to purchase a single share of Common Stock for $1.39; 115,000 warrants
which can be exercised  until  February  2003 each to purchase a single share of
Common Stock for $1.59;  955,000  warrants which can be exercised until February
2007 each to purchase a single share of Common Stock for $1.59;  75,000 warrants
which can be  exercised  until  March 2007 each to  purchase  a single  share of
Common Stock for $1.66;  68,421 warrants which can be exercised until March 2008
each to purchase a single share of Common Stock for $1.38;  and 15,000  warrants
which can be  exercised  until  April 2003 each to  purchase  a single  share of
Common Stock for $1.22.

Nevada Anti-Takeover Laws

     The Company is subject to the provisions of Sections  78.411 through 78.444
of  the  Nevada  Law,  an  anti-takeover   statute  (the  "Business  Combination
Statute").   In  general,   the  Business   Combination   Statute   prohibits  a
publicly-held  Nevada  corporation  from  engaging  in a  "combination"  with an
"interested  stockholder"  for a period  of three  years  after  the date of the
transaction  in which the person became an interested  stockholder,  unless such
combination is approved in a prescribed  manner or satisfies  certain fair value
requirements.   For  the   purposes  of  the   Business   Combination   Statute,
"combination"  includes a merger, an asset sale, the issuance or transfer by the
corporation of its shares in one transaction or a series of transactions, having
an aggregate  fair market  value equal to five percent or more of the  aggregate
market  value  of  the  corporation's  outstanding  shares,  to  the  interested
stockholder or to an associate of the interested stockholder,  and certain other
types  of  transactions   resulting  in  a  financial   benefit  the  interested
stockholder.  An  "interested  stockholder"  is a person  who is the  beneficial
owner,  directly  or  indirectly,  of ten  percent or more of the  corporation's
voting stock or an affiliate  or associate of the  corporation  that at any time
within  the three  years  immediately  preceding  the date in  question  was the
beneficial  owner,  directly  or  indirectly,  of ten  percent  or  more  of the
corporation's voting stock.

     By an amendment to its  By-laws,  the Company has exempted  itself from the
provisions  of  Sections  78.378  through  78.3793 of the Nevada Law, a "control
share"  statute which  otherwise  prohibits an acquiring  person,  under certain
circumstances,  from voting certain shares of a target corporation's stock after
such acquiring person's percentage of ownership of such corporation's

                                       13

<PAGE>


stock crosses certain thresholds,  unless the target corporation's disinterested
stockholders approve the granting of voting rights to such shares.

Transfer Agent and Registrar

     The transfer agent and registrar for the Company's Common Stock is American
Stock Transfer and Trust Company, New York, New York.


                              PLAN OF DISTRIBUTION

     The Shares offered hereby by the Selling  Stockholder are 9,050,000  shares
of Common Stock issuable upon conversion of 8,000 shares  ($8,000,000  principal
amount) Series C Preferred Stock issued to the holders thereof by the Company in
connection with the Private Placement Transaction (of the 8,000 share only 5,000
are  currently  issued and the Company may, at it's option,  issue the remaining
3,000 to the Selling  Stockholder).  This prospectus also covers the issuance by
the  Company of up to 950,000  shares of Common  Stock upon the  exercise of the
Warrants,   which  were  issued  in  connection   with  the  Private   Placement
Transaction,  and 171,052  shares of Common  Stock upon the exercise of Warrants
which were issued in connection with the 1997 Private Placement Transaction.

     The Company will receive no proceeds  from this  offering  (other than from
the  exercise of the  Warrants).  The Shares  offered  hereby may be sold by the
Selling Stockholder or by pledgees,  donees,  transferees or other successors in
interest that receive such shares as a gift,  partnership  distribution or other
non-sale  related  transfer.  The  Shares  may be  sold  from  time  to  time in
transactions in the over-the-counter  market, in negotiated  transactions,  or a
combination  of such methods of sale,  at fixed prices which may be changed,  at
market prices  prevailing  at the time of sale, at prices  related to prevailing
market prices or at negotiated prices.  The Selling  Stockholder may effect such
transactions by selling the Shares to or through broker-dealers, including block
trades in which  brokers or dealers will attempt to sell the Shares as agent but
may position and resell the block as principal to facilitate the transaction, or
in one or more underwritten offerings on a firm commitment or best effort basis.
Sales of  Selling  Stockholder's  Shares may also be made  pursuant  to Rule 144
under the Securities Act, where applicable.

     To the extent  required under the Securities  Act, the aggregate  amount of
Selling  Stockholder's  Shares being offered and the terms of the offering,  the
names of any such agents,  brokers,  dealers or underwriters  and any applicable
commission  with  respect  to a  particular  offer  will  be  set  forth  in  an
accompanying Prospectus supplement. Any underwriters, dealers, brokers or agents
participating in the distribution of the Shares may receive  compensation in the
form of  underwriting  discounts,  concessions,  commissions  or fees  from  the
Selling Stockholder and/or purchasers of Selling  Stockholder's Shares, for whom
they may act (which  compensation as to a particular  broker-dealer  might be in
excess of customary commissions).

     From time to time, the Selling Stockholder may pledge, hypothecate or grant
a security  interest in some or all of the  Shares,  and the  pledgees,  secured
parties or persons to whom such

                                       14

<PAGE>



securities  have  been  hypothecated  shall,  upon  foreclosure  in the event of
default, be deemed to be Selling Stockholder hereunder. In addition, the Selling
Stockholder may, from time to time, sell short the Shares of the Company, and in
such  instances,  this Prospectus may be delivered in connection with such short
sales and the Shares offered hereby may be used to cover such short sales.

     The Selling Stockholder may transfer,  pledge, donate or assign it's Shares
to lenders or others  and each of such  persons  will be deemed to be a "Selling
Stockholder"  for  purposes  of  the  Prospectus.  The  number  of  the  Selling
Stockholder's  Shares beneficially owned by a Selling Stockholder who transfers,
pledges,  donates or assigns  Shares  will  decrease  as and when they take such
actions,  The  plan  of  distribution  for  Selling  Stockholders'  Shares  sold
hereunder  will  otherwise  remain  unchanged,   except  that  the  transferees,
pledgees, donees or other successors will be a Selling Stockholder hereunder.

     A  Selling   Stockholder   may  enter  into   hedging   transactions   with
broker-dealers,  and the  broker-dealers may engage in short sales of the Shares
in  the  course  of  hedging  the  positions   they  assume  with  such  Selling
Stockholder,  including, without limitation , in connection with distribution of
the Shares by such  broker-dealers.  The Selling Stockholder may also enter into
option or other  transactions with  broker-dealers  that involve the delivery of
the Shares to the broker-dealers, who may then resell or otherwise transfer such
Shares.  The  Selling  Stockholder  may also  loan or  pledge  the  Shares  to a
broker-dealer  and the  broker-dealer  may sell the  Shares  as loaned or upon a
default may sell or otherwise transfer the pledge Shares.

     In  order  to  comply  with  the  securities  laws of  certain  states,  if
applicable,  the  Shares  will  be  sold  in  such  jurisdictions  only  through
registered or licensed  brokers or dealers.  In addition,  in certain states the
Shares may not be sold unless they have been registered or qualified for sale in
the applicable  state or an exemption  from the  registration  or  qualification
requirement is available.

     The Selling  Stockholder and any broker-dealers or agents that participates
with the Selling  Stockholder in the distribution of the Shares may be deemed to
be  "underwriter"  within the meaning of the Securities Act, and any commissions
received  by them and any profit on the resale of the Shares  purchased  by them
may be deemed to be underwriting commissions under the Securities Act.


     The  Company  has agreed to pay  certain  costs and  expenses  incurred  in
connection  with the  registration of the shares of Common Stock offered hereby,
except  that the  Selling  Stockholder  shall  be  responsible  for all  selling
commissions, transfer taxes and related charges in connection with the offer and
sale of such shares.

     The Company  has agreed to keep the  Registration  Statement  of which this
Prospectus  forms a part  continuously  effective  until the earlier of the date
that all of such  Shares  have  been sold or three  years  from the date of this
Prospectus.


                             SELLING SECURITY HOLDER


                                       15

<PAGE>


     The table below sets forth the name of the Selling  Stockholder;  the total
amount of (i) shares of Common Stock  beneficially owned by such security holder
as of March 2, 1998;  (ii)  Warrant  Shares  issuable  upon the  exercise of the
Warrants  beneficially owned by such security holder; (iii) the aggregate amount
of Common  Stock  and/or  Warrant  Shares  which may be offered for sale for the
account of such security holder in his/her discretion from time to time pursuant
to this  Prospectus;  and (iv) the amount and  percentage  of Common Stock which
would be beneficially owned by such security holder after sale of all securities
offered by the  Selling  Stockholder  pursuant to this  Prospectus,  if they are
offered and sold,  and  assuming  that any other  shares  held by such  security
holders are not sold. The information  included below is based upon  information
provided by the Selling Stockholder.  The Selling Stockholder referred to herein
has not held any position or office, or had any material relationship,  with the
Company or any of its  predecessors  or affiliates  within the last three years,
except as noted below,  and the Selling  Stockholder  will not own 1% or more of
the outstanding stock of the Company after completion of the offering, except as
noted below.

     For the  purposes  of  calculating  the  number of  shares of Common  Stock
beneficially  owned by the Selling  Stockholder,  the number of shares of Common
Stock  calculated to be issuable in connection with the conversion of the Series
C Preferred  Stock is based on a conversion  price of $1.9688,  which is derived
from 90% of the lowest  trading  price of the Common  Stock as of March 2, 1998.
The  calculation  of the total  number of shares of Common  Stock to be  offered
hereby,  however, is based on a hypothetical market price of the Common Stock at
the time of such conversion of $0.98 per share (approximate  conversion price of
$0.88),  which price is below the lowest trading price of the Common Stock as of
March 2, 1998 (which was  $2.1875).  The use of such  hypothetical  price is not
intended,  and should in no way be  construed,  to constitute a prediction as to
the future market price of the Common Stock.

     Because  the  initial  issuance  by the  Company of the  Warrant  Shares to
non-affiliated  holders is covered by the  Registration  Statement of which this
Prospectus  forms a part and the resale thereof by such  non-affiliated  holders
need not be registered  under the Securities  Act, the table below does not list
the warrants held by the non-affiliated Selling Stockholder.

<TABLE>
<CAPTION>
============================================================================================================================
                                                    Amount of          Shares of          Shares and Percentage of          
                                 Shares of          Warrant Shares     Common Stock       Shares Owned After                
             Names               Common Stock       Issuable upon      and/or Warrant     Completion of Offering            
(and position or office held in  Beneficially       Exercise of        Shares             --------------------------------- 
the Company)                     Owned (1)          Warrants (2)       Offered(3)         Shares           Percentage       
============================================================================================================================

<S>                               <C>                  <C>              <C>                 <C>                <C>
CC Investments, LDC               9,050,000            800,000          9,850,000           0                  0
</TABLE>

- --------------------

*    Indicates ownership of less than 1%

(1)  Does not include the Warrants.

(2)  Consists of 500,000  Warrants shares issuable upon the exercise of Warrants
     currently  held by the  Selling  Stockholder  and  300,000  Warrant  shares
     issuable to the Selling Stockholder at the option of the Company.


                                       16

<PAGE>


(3)  Consists of shares of Common Stock issuable upon conversion of 5,000 shares
     of Series C Preferred Stock  currently held by the Selling  Stockholder and
     3,000 shares which may be issued to the Selling  Stockholder  at the option
     of the Company,  assuming a conversion price of $0.88. Does not include the
     Warrant Shares  because the initial  issuance by the Company of the Warrant
     Shares to non-affiliated  holders is covered by the Registration  Statement
     of which  this  Prospectus  forms a part  and the  resale  thereof  by such
     non-affiliated  holders need not be registered  under the  Securities  Act.
     Except under certain limited circumstances,  the Selling Stockholder of the
     Series C Preferred  Stock is not entitled to convert such securities to the
     extent  that the Shares to be  received  upon such  conversion  or exercise
     would  cause such holder to  beneficially  own more that 4.9% of the Common
     Stock of the Company.  Therefore, the number of shares set forth herein and
     which the  Selling  Stockholder  may sell  pursuant to the  Prospectus  may
     exceed the number of shares of Common Stock the Selling  Stockholder  would
     otherwise  beneficially own as determined  pursuant to Section 13(d) of the
     Exchange  Act.  Moreover,  pursuant  to the  regulations  of  the  National
     Association of Securities Dealers, in the absence of shareholder  approval,
     the  aggregate  number of shares of Common  Stock  issuable  to the Selling
     Stockholder  at a  discount  from  market  price  upon  conversion  of  the
     Preferred Stock may not exceed 19.99% of the  outstanding  shares of Common
     Stock . Unless  shareholder  approval is obtained to issue  Common Stock to
     the Selling  Stockholder  in excess of the maximum  amount set forth above,
     the  Selling  Stockholder  will not be  entitled  to acquire  more than its
     proportionate  share of such maximum amount.  Any Preferred Stock which may
     not be  converted  because  of  such  limitation  must be  redeemed  by the
     Company.



                                       17

<PAGE>


                               RECENT DEVELOPMENTS

     On January 1, 1998,  Robert  Cook was  appointed  to the  position  of Vice
President-  Finance and Chief Financial Officer.  Prior to joining Pharmos,  Mr.
Cook was Vice  President in the  Healthcare  Group of General  Electric  Capital
Corporation's  Commercial Finance unit, working with pharmaceutical companies as
well as  middle-market  and  emerging  companies.  Prior to  working  at General
Electric, Mr. Cook was at Chase Manhattan Bank for 18 years.


                 INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

     The  following  documents  filed by the  Company  with the  Commission  are
incorporated herein by reference:

     (a) The  Company's  Annual  Report on Form 10-K,  for the fiscal year ended
December 31, 1996, filed pursuant to Section 13 of the Exchange Act.

     (b)  The  description  of the  Common  Stock  contained  in  the  Company's
Registration  Statement on Form 8-A dated  January 30, 1984,  filed  pursuant to
Section 12 of the Exchange Act.

     (c) The  Company's  Quarterly  Reports on Form 10Q, for the quarters  ended
March 31, 1997, June 30, 1997 and September 30, 1997.

     (d) The  Company's  Current  Report on Form  8-K,  including  the  exhibits
thereto, dated September 16, 1997.

     (e) The  Company's  Current  Report on Form  8-K,  including  the  exhibits
thereto, dated February 4, 1998.


     In  addition,  all reports and other  documents  to be filed by the Company
pursuant to Sections  13(a),  13(c),  14 and 15(d) of the Exchange Act, prior to
the filing of a  post-effective  amendment  which  indicates that all securities
offered hereby have been sold or which deregisters all securities offered hereby
then remaining  unsold,  as well as all such reports filed after the date hereof
and  prior  to  the  termination  of  this  offering,  shall  be  deemed  to  be
incorporated  by  reference  herein and shall be deemed to be a part hereof from
the date of the filing of each such report or document.


                     COMMISSION'S POLICY ON INDEMNIFICATION
                         FOR SECURITIES ACT LIABILITIES

     Article 12 of the Company's Restated Articles of Incorporation  directs the
Company to provide in its bylaws for provisions  relating to the indemnification
of directors  and officers to the full extent  permitted by law,  including  the
federal  securities  law.  Section  78.751 of the Nevada  Revised  Statutes,  as
amended,  authorizes  the Company to  indemnify  any  director or officer  under
certain  prescribed  circumstances  and subject to certain  limitations  against
certain costs and

                                       18

<PAGE>



expenses,   including  attorneys'  fees  actually  and  reasonably  incurred  in
connection  with  any  action,  suit or  proceeding,  whether  civil,  criminal,
administrative  or  investigative,  to which such person is a party by reason of
being a director or officer of the Company if it is determined  that such person
acted in accordance  with the  applicable  standard of conduct set forth in such
statutory  provisions.  The Company may also purchase and maintain insurance for
the  benefit of any  director  or officer  which may cover  claims for which the
Company could not indemnify such person.

     Insofar as  indemnification  for  liabilities  arising under the Act may be
permitted to directors,  officers, and controlling persons of the Company, or to
underwriters (or controlling  persons thereof) of which an officer,  partner, or
controlling  person  thereof is one of the  foregoing  pursuant to the foregoing
provisions or otherwise, the Company has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public policy
as expressed in the Act and is,  therefore,  unenforceable.  In the event that a
claim for  indemnification  against such liabilities  (other than the payment by
the Company of expenses incurred or paid by any such persons,  in the successful
defense of any action,  suit or  proceeding)  is asserted by any such persons in
connection with the securities being registered, the Company will, unless in the
opinion of its counsel  the matter has been  settled by  controlling  precedent,
submit to a court of  appropriate  jurisdiction  the  question  of whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.

                                 LEGAL OPINIONS

     Legal matters in connection  with the securities  being offered hereby will
be passed upon for the Company by Ehrenreich  Eilenberg  Krause & Zivian LLP, 11
East 44th Street, 17th Floor, New York, NY 10017. 

                                    EXPERTS

     The financial  statements  incorporated  in this Prospectus by reference to
the Annual Report on Form 10-K for the year ended  December 31, 1996,  have been
so incorporated in reliance on the report of Price  Waterhouse LLP,  independent
accountants,  given on the  authority  of said firm as experts in  auditing  and
accounting.

                                       19

<PAGE>


                               PHARMOS CORPORATION

                                 March __, 1998



                                      INDEX



                                                                        Page No.


THE COMPANY ...............................................................    1

RISK FACTORS ..............................................................    1

DILUTION ..................................................................   10

USE OF PROCEEDS ...........................................................   10

DESCRIPTION OF SECURITIES .................................................   11

PLAN OF DISTRIBUTION ......................................................   14

SELLING SECURITY HOLDER ...................................................   16

RECENT DEVELOPMENTS .......................................................   18

INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE ...........................   18

COMMISSION'S POLICY ON INDEMNIFICATION
FOR SECURITIES ACT LIABILITIES ............................................   18

LEGAL OPINIONS ............................................................   19

EXPERTS ...................................................................   19





<PAGE>

                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution

     The following  statement  sets forth the  estimated  expenses in connection
with the offering described in the Registration  Statement,  assuming all of the
Warrants are exercised at their respective  exercise price (all of which will be
borne by the Registrant).


Securities and Exchange Commission Fee                                   $ 6,728
Printing and Engraving Expenses                                              100
Accountants' Fees and Expenses                                             3,000
Legal Fees and Expenses                                                   60,000
Blue Sky Filing Fees                                                       1,500
Miscellaneous                                                                672
                                                                         -------

TOTAL                                                                    $72,000
                                                                         =======

Item 15. Indemnification of Directors and Officers.

     Article 12 of the  Registrant's  Certificate of  Incorporation  directs the
Registrant   to  provide  in  its  bylaws  for   provisions   relating   to  the
indemnification  of directors and officers to the full extent  permitted by law.
Section  78.751 of the Nevada  Revised  Statutes,  as  amended,  authorizes  the
Registrant  to  indemnify  any  director  or officer  under  certain  prescribed
circumstances  and  subject to certain  limitations  against  certain  costs and
expenses,   including  attorneys'  fees  actually  and  reasonably  incurred  in
connection  with  any  action,  suit or  proceeding,  whether  civil,  criminal,
administrative  or  investigative,  to which such person is a party by reason of
being a director  or officer of the  Registrant  if it is  determined  that such
person acted in accordance with the applicable  standard of conduct set forth in
such statutory provisions.

     The Registrant may also purchase and maintain  insurance for the benefit of
any director or officer  which may cover claims for which the  Registrant  could
not indemnify such person.

Item 16.     Exhibits
- --------     --------

     4(a)      Specimen of Common Stock  Certificate  (incorporated by reference
               to Form S-3 Registration  Statement of the Company dated November
               25, 1994 [No. 33-86720])

     4(b)      Restated Articles of Incorporation  (incorporated by reference to
               Appendix E to the Joint Proxy Statement/  Prospectus  included in
               the

                                      II-1

<PAGE>



               Form S-4 Registration Statement of the Registrant dated September
               28, 1992 [No. 33-52398])


     4(c)      Certificate  of Amendment of Restated  Articles of  Incorporation
               (incorporated by reference to the Company's Annual Report on Form
               10- K for the year ended December 31, 1994 [No. 0-11550])

     *4(d)     Certificate  of Amendment of Restated  Articles of  Incorporation
               dated January 16, 1998

     4(e)      Certificate of Designation, Rights, Preferences and Privileges of
               Series  A  Preferred  Stock  of  the  Company   (incorporated  by
               reference to Form S-3 Registration Statement of the Company dated
               December 20, 1996 [No. 333-15165])

     4(f)      Certificate of Designation, Rights, Preferences and Privileges of
               Series  B  Preferred  Stock  of  the  Company   (incorporated  by
               reference to Form S-3 Registration Statement of the Company dated
               April 30, 1997 [No. 333- 26155

     4         (g)   Certificate  of   Designation,   Rights,   Preferences  and
               Privileges of Series C Convertible Preferred Stock of the Company
               (incorporated  by reference to the  Company's  Current  Report on
               Form 8-K filed on February 6, 1998)

     4(h)      Amended and Restated  By-Laws  (incorporated by reference to Form
               S-1  Registration  Statement  of the Company  dated June 30, 1994
               [No. 33- 80916])

     4(i)      Form Stock Securities  Purchase Agreement dated as of February 4,
               1998  between  the  Company  and the  Investor  (incorporated  by
               reference to the  Company's  Current  Report on Form 8-K filed on
               February 6, 1998)

     4(j)      Form of Stock  Purchase  Warrant  dated as of  February  4,  1998
               between  the  Company  and the  Investor  and the Company and the
               Placement  Agent  (incorporated  by  reference  to the  Company's
               Current Report on Form 8- K filed on February 6, 1998)

     *4(k)     Form of Stock Purchase Warrant dated as of March 31, 1997 between
               the Company and the Investor

     *5        Opinion re: legality


                                      II-2

<PAGE>


     23(a)     Consent of Ehrenreich  Eilenberg Krause & Zivian LLP (included in
               the Opinion filed as Exhibit 5)

     *23(b)    Consent of Price Waterhouse LLP

- ---------------

*    Filed herewith.


Item 17. Undertakings.

         The undersigned Registrant hereby undertakes;

     (1) To file,  during any period in which  offers or sales are being made, a
post-effective amendment to this registration statement:

          (i) To include  any  prospectus  required  by section  10(a)(3) of the
     Securities Act of 1933;

          (ii) To reflect in the  prospectus  any facts or events  arising after
     the  effective  date of the  registration  statement  (or the  most  recent
     post-effective amendment thereof) which,  individually or in the aggregate,
     represent  a  fundamental  change  in  the  information  set  forth  in the
     registration statement;

          (iii) To include any material  information with respect to the plan of
     distribution not previously disclosed in the registration  statement or any
     material change to such information in the registration statement.

     Provided,  however,  that Paragraphs (i) and (ii) above do not apply if the
Registration  Statement  is on  Form  S-3  and the  information  required  to be
included in a  post-effective  amendment  by those  paragraphs  is  contained in
periodic reports filed by the registrant pursuant to Section 13 or Section 15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the
Registration Statement.

     (2) That, for the purpose of determining any liability under the Securities
Act of 1933,  each  such  post-effective  amendment  shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (3) To remove from registration by means of a post-effective  amendment any
of the securities being registered which remain unsold at the termination of the
offering.

     (4) That, for the purpose of determining any liability under the Securities
Act of 1933, each filing of the  registrant's  annual report pursuant to Section
13(a) or 15(d) of the Securities  Exchange Act of 1934 (and,  where  applicable,
each filing of an employee benefit plan's annual

                                      II-3

<PAGE>



report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is
incorporated by reference in the registration  statement shall be deemed to be a
new registration  statement relating to the securities offered therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors,  officers and controlling  persons of the
Registrant pursuant to the foregoing  provisions,  or otherwise,  the Registrant
has been advised that in the opinion of the Securities  and Exchange  Commission
such  indemnification  is against  public policy as expressed in the Act and is,
therefore  unenforceable.  In the event that a claim for indemnification against
such liabilities  (other than the payment by the Registrant of expenses incurred
or paid by a director,  officer,  or controlling person of the Registrant in the
successful  defense of any  action,  suit or  proceeding)  is  asserted  by such
director,  officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

                                      II-4

<PAGE>


                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-3 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the City of  Iselin  and  State of New  Jersey on the 5th day of
March, 1998.

                                       PHARMOS CORPORATION

                                       By:/s/       Dr. Haim Aviv
                                          ------------------------------------
                                          Dr. Haim Aviv, Chairman, Chief
                                          Scientist, Chief Executive Officer
                                          and Director (Principal Executive
                                          Officer)

Pursuant to the  requirements of the Securities Act of 1933,  this  registration
statement or amendment  has been signed  below by the  following  persons in the
capacities and on the dates indicated:


Signature                        Title                                   Date
- ---------                        -----                                   ----
/s/ Robert Cook                  Chief Financial Officer           March 5, 1998
- ----------------------------     (Principal Financial and   
Robert Cook                      Accounting Officer)

/s/ Dr. Gad Riesenfeld                                             March 5, 1998
- ----------------------------     President, Chief Operating
Dr. Gad Riesenfeld               Officer and Acting Secretary              

/s/ Marvin P. Loeb               Director                          March 5, 1998
- ----------------------------     
Marvin P. Loeb

/s/ E. Andrews Grinstead III     Director                          March 5, 1998
- ----------------------------
E. Andrews Grinstead III

/s/ Stephen C. Knight            Director                          March 5, 1998
- ----------------------------
Stephen C. Knight

/s/ David Schlachet              Director                          March 5, 1998
- ----------------------------
David Schlachet

/s/ Fredric D. Price             Director                          March 5, 1998
- ----------------------------
Fredric D. Price

/s/ Mony Ben Dor                 Director                          March 5, 1998
- ----------------------------
Mony Ben Dor


                                      II-5



                            CERTIFICATE OF AMENDMENT
                                       OF
                       RESTATED ARTICLES OF INCORPORATION
                                       OF
                               PHARMOS CORPORATION
                              a Nevada Corporation


The undersigned hereby certify as follows:

     1. That,  respectively,  they are the  President  and  Secretary of Pharmos
Corporation, a Nevada Corporation (the "Corporation");

     2. That the original  Articles of  Incorporation  of the  Corporation  were
filed in the Office of the Secretary of State of the State of Nevada on the 20th
day of December, 1982;

     3. That the Restated  Articles of  Incorporation  of the  Corporation  were
filed in the Office of the Secretary of State of the State of Nevada on the 29th
day of October, 1992;

     4. That a Certificate  of Amendment of Restated  Articles of  Incorporation
was filed on January 30, 1995;

     5.  That  capital  has  been  paid to the  Corporation,  and  stock  of the
Corporation has been issued;

     6. That at a meeting of the Corporation's  Board of Directors (the "Board")
held on November 25, 1997,  the Board  unanimously  consented to and approved an
amendment  to  Article  FOURTH  of  the   Corporation's   Restated  Articles  of
Incorporation  to increase  the  Corporation's  authorized  capital  stock to 60
million shares of Common Stock (the "Amendment");

     7. That at a meeting of the  Corporation's  stockholders held on January 9,
1998,  the  Corporation's  stockholders  voted  for  the  Amendment,  and  that,
therefore,   Article   FOURTH  of  the   Corporation's   Restated   Articles  of
Incorporation is amended to read as follows:

          "FOURTH.  The total  number of shares of stock  which the  corporation
     shall  have  authority  to issue is sixty one  million  two  hundred  fifty
     thousand (61,250,000),  of which stock sixty million (60,000,000) shares of
     the par value of Three Cents  ($0.03)  each,  amounting in the aggregate to
     One Million Eight Hundred  Thousand Dollars  ($1,800,000),  shall be Common
     Stock,  and of which one  million two hundred  fifty  thousand  (1,250,000)
     shares of the par  value of Three  Cents  ($0.03)  each,  amounting  in the
     aggregate to Thirty Seven Thousand Five Hundred Dollars ($37,500), shall be
     Preferred Stock.

     The Board of Directors  shall have the authority to fix by  Resolution  the
voting  powers (full,  limited,  multiple,  fractional  or none),  designations,
preferences,  qualifications,  privileges,  limitations,  restrictions, options,
conversion rights and other special or


<PAGE>



relative  rights of the Preferred  Stock or any class or series thereof prior to
or concurrently with the issuance of such shares.

     There shall be no cumulative voting rights for the Common Stock.

     The holders of the Common Stock and the  Preferred  Stock shall be entitled
to  dividends,  when,  as and if  declared  by the  Board  of  Directors  of the
Corporation,  payable  at such  time or times  as the  Board  of  Directors  may
determine.

     Subject to the  determination  of the Board of Directors with regard to the
Preferred Stock, in the event of any  liquidation,  dissolution or winding up of
the affairs of the corporation,  whether voluntary or involuntary, all remaining
assets  and  funds  of  the  corporation   available  for  distribution  to  its
stockholders  shall be  distributed  in equal  amounts  per  share  and  without
preference or priority of one class of common stock over the other.

     Any action may be taken by the  stockholders  of the  corporation  by their
written consent without a stockholders' meeting.

     No stockholder of this corporation shall by reason of his holding shares of
any class have any preemptive or preferential  right to purchase or subscribe to
any shares of any class of this corporation,  now or hereafter to be authorized,
or any  notes,  debentures,  bonds,  or  other  securities  convertible  into or
carrying  options or warrants to purchase shares of any class,  now or hereafter
to be authorized, whether or not the issuance of any such shares, or such notes,
debentures,  bonds or other  securities,  would adversely affect the dividend or
voting rights of such stockholder,  other than such rights, if any, as the board
of directors,  in its discretion from time to time may grant,  and at such price
as the board of directors in its  discretion may fix; and the board of directors
may issue  shares of any class of this  corporation,  or any notes,  debentures,
bonds, or other  securities  convertible into or carrying options or warrants to
purchase  shares of any class,  without  offering  any such shares of any class,
either in whole or in part, to the existing stockholders of any class."

     IN WITNESS  WHEREOF,  the  undersigned  have executed this  Certificate  of
Amendment  of Restated  Articles of  Incorporation  on this ____ day of January,
1998.


                                                             -------------------
                                                             Gad Riesenfeld
                                                             President


                                                             -------------------
                                                             Robert W. Cook
                                                             Secretary




THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE UNITED STATES  SECURITIES AND
EXCHANGE  COMMISSION OR THE  SECURITIES  COMMISSION OF ANY STATE  PURSUANT TO AN
EXEMPTION FROM REGISTRATION  UNDER REGULATION D PROMULGATED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE "1933 ACT").  THIS STOCK PURCHASE WARRANT SHALL NOT
CONSTITUTE AN OFFER TO SELL NOR A SOLICITATION OF AN OFFER TO BUY THE SECURITIES
IN ANY JURISDICTION IN WHICH SUCH OFFER OR SOLICITATION  WOULD BE UNLAWFUL.  THE
SECURITIES  ARE  "RESTRICTED"  AND MAY NOT BE  RESOLD OR  TRANSFERRED  EXCEPT AS
PERMITTED UNDER THE 1933 ACT PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM.

No. W-97D-5

                             STOCK PURCHASE WARRANT
                  To Purchase 171,052 Shares of Common Stock of

                               PHARMOS CORPORATION


     THIS CERTIFIES that, for value  received,  ALAN M. MARK, with an address at
Marksman  Capital  Advisors,  41  Seminole  Way,  Short  Hills,  NJ  07078  (the
"Finder"), is entitled, upon the terms and subject to the conditions hereinafter
set forth, at any time on or after March 31, 1998 (the "Initial  Exercise Date")
and on or prior to March 31, 2008 (the  "Termination  Date") but not thereafter,
to subscribe for and purchase  from PHARMOS  CORPORATION,  a Nevada  corporation
(the  "Company"),  171,052  shares of the  Company's  Common Stock (the "Warrant
Shares"). The purchase price of one share of Common Stock (the "Exercise Price")
under this  Warrant  shall be One Dollar and  Thirty-Eight  Cents  ($1.38).  The
Exercise  Price and the number of Warrant  Shares shall be subject to adjustment
as  provided  herein.  This  warrant  is being  issued  in  connection  with the
Preferred Stock Securities Purchase  Agreements,  dated March 31, 1997, complete
with all listed  exhibits  thereto  (the  "Agreement")  between  the Company and
Elliott Associates,  L.P., Paresco,  Inc., Libertyview Fund, LLC and Libertyview
Plus Fund and is subject to its terms. In the event of any conflict  between the
terms of this Warrant and the Agreement, the Agreement shall control.

     1.  Title of  Warrant.  Prior  to the  expiration  hereof  and  subject  to
compliance  with  applicable  laws,  this Warrant and all rights  hereunder  are
transferable,  in whole or in part,  at the office or agency of the Company,  by
the holder hereof in person or by duly  authorized  attorney,  upon surrender of
this Warrant together with the Assignment Form annexed hereto properly endorsed.

     2. Authorization of Shares. The Company covenants that all shares of Common
Stock  which may be issued  upon the  exercise  of  rights  represented  by this
Warrant will, upon exercise of the rights  represented by this Warrant,  be duly
authorized,  validly  issued,  fully  paid and  nonassessable  and free from all
taxes,  liens and charges in respect of the issue  thereof  (other than taxes in
respect of any transfer occurring contemporaneously with such issue).


<PAGE>


     3. Exercise of Warrant. Exercise of the purchase rights represented by this
Warrant may be made at any time or times,  in whole or in part,  on or after the
Initial  Exercise  Date,  or such earlier  date as provided in  paragraph  11(c)
below, and before the close of business on the Termination Date, or such earlier
date on which this Warrant may  terminate as provided in paragraph  11(a) below,
by the surrender of this Warrant and the  Subscription  Form annexed hereto duly
executed,  at the office of the Company  (or such other  office or agency of the
Company as it may designate by notice in writing to the registered holder hereof
at the address of such holder  appearing  on the books of the  Company) and upon
payment of the Exercise  Price of the shares  thereby  purchased;  whereupon the
holder of this Warrant shall be entitled to receive a certificate for the number
of shares of Common Stock so purchased immediately. In the event upon exercising
the Warrant,  the  transfer  agent  requires an opinion of counsel,  the Company
shall have such opinion  furnished to the transfer agent to the transfer agent's
satisfaction.  In  the  event  the  Finder  is  relying  on  an  exemption  from
registration under the 1933 Act, the Shares shall be issued immediately,  if the
Finder furnishes an opinion of counsel,  reasonably satisfactory to the Company,
that such  exemption from  registration  is available.  Certificates  for shares
purchased  hereunder  shall be  delivered  to the  holder  hereof  within  three
business days after the date on which this Warrant shall have been  exercised as
aforesaid. Payment of the Exercise Price of the shares may be by certified check
or cashier's  check or by wire transfer to an account  designated by the Company
in an amount  equal to the  Exercise  Price  multiplied  by the number of shares
being purchased.

     4.  No  Fractional   Shares  or  Scrip.  No  fractional   shares  or  scrip
representing  fractional  shares  shall  be  issued  upon the  exercise  of this
Warrant.

     5. Charges,  Taxes and  Expenses.  Issuance of  certificates  for shares of
Common Stock upon the exercise of this Warrant  shall be made without  charge to
the holder hereof for any issue or transfer tax or other  incidental  expense in
respect of the  issuance of such  certificate,  all of which taxes and  expenses
shall be paid by the Company,  and such certificates shall be issued in the name
of the holder of this Warrant or in such name or names as may be directed by the
holder of this Warrant;  provided,  however,  that in the event certificates for
shares of Common  Stock  are to be issued in a name  other  than the name of the
holder of this  Warrant,  this Warrant when  surrendered  for exercise  shall be
accompanied by the Assignment  Form attached  hereto duly executed by the holder
hereof, together with evidence satisfactory to the Company that such transfer or
assignment is being made in  compliance  with all  applicable  federal and state
securities laws; and provided  further,  that upon any transfer  involved in the
issuance or delivery of any certificates for shares of Common Stock, the Company
may  require,  as a  condition  thereto,  the  payment  of a sum  sufficient  to
reimburse it for any transfer tax incidental thereto.

     6.  Closing of Books.  The  Company  will at no time close its  shareholder
books or records in any manner which interferes with the timely exercise of this
Warrant.


                                       2

<PAGE>

     7. No Rights as Shareholder  until Exercise.  This Warrant does not entitle
the holder hereof to any voting  rights or other rights as a shareholder  of the
Company prior to the exercise thereof. If, however, at the time of the surrender
of this  Warrant and  purchase  the holder  hereof shall be entitled to exercise
this  Warrant,  the shares so  purchased  shall be and be deemed to be issued to
such  holder as the record  owner of such  shares as of the close of business on
the date on which this Warrant shall have been exercised.

     8. Assignment and Transfer of Warrant.  This Warrant may be assigned by the
surrender of this Warrant and the  Assignment  Form annexed hereto duly executed
at the office of the Company  (or such other  office or agency of the Company as
it may  designate by notice in writing to the  registered  holder  hereof at the
address  of such  holder  appearing  on the  books  of the  Company);  provided,
however, that this Warrant may not be resold or otherwise transferred except (i)
in a transaction  registered  under the Securities Act, or (ii) in a transaction
pursuant to an exemption,  if available,  from such registration and whereby, if
requested by the Company,  an opinion of counsel reasonably  satisfactory to the
Company  is  obtained  by the  holder of this  Warrant  to the  effect  that the
transaction is so exempt.

     9.  Loss,  Theft,   Destruction  or  Mutilation  of  Warrant.  The  Company
represents and warrants that upon receipt by the Company of evidence  reasonably
satisfactory to it of the loss, theft,  destruction or mutilation of any Warrant
or stock certificate, and in case of loss, theft or destruction, of indemnity or
security reasonably satisfactory to it, and upon reimbursement to the Company of
all reasonable expenses incidental thereto,  and upon surrender and cancellation
of such Warrant or stock  certificate,  if mutilated,  the Company will make and
deliver a new  Warrant or stock  certificate  of like tenor and dated as of such
cancellation, in lieu of this Warrant or stock certificate.

     10. Saturdays, Sundays, Holidays, etc. If the last or appointed day for the
taking of any action or the  expiration of any right  required or granted herein
shall be a Saturday, Sunday or a legal holiday, then such action may be taken or
such right may be exercised on the next succeeding day not a legal holiday.

     11. Effect of Certain Events.

     (a) If at any time the Company proposes (i) to sell or otherwise convey all
or substantially all of its assets or (ii) to effect a transaction (by merger or
otherwise) in which more than 50% of the voting power of the Company is disposed
of (collectively, a "Sale or Merger Transaction"), in which the consideration to
be received  by the Company or its  shareholders  consists  solely of cash,  the
Company  shall give the holder of this  Warrant  thirty (30) days' notice of the
proposed  effective date of the  transaction  specifying  that the Warrant shall
terminate  if the Warrant has not been  exercised by the  effective  date of the
transaction.

     (b) In  case  the  Company  shall  at any  time  effect  a Sale  or  Merger
Transaction  in which the  consideration  to be  received  by the Company or its
shareholders consists in part of


                                       3
<PAGE>

consideration other than cash, or shall issue any shares of its capital stock in
a  reclassification  of the Common Stock,  the holder of this Warrant shall have
the right thereafter to purchase, by exercise of this Warrant and payment of the
aggregate  Exercise Price in effect  immediately prior to such action,  the kind
and amount of shares and other securities and property which it would have owned
or have been  entitled to receive after the  happening of such  transaction  had
this Warrant been exercised immediately prior thereto.

     (c) The Initial Exercise Date shall be accelerated in the event of a Change
in Control or a Going Private Transaction, as defined under the Agreement.

     12.  Registration  Rights.  The Company shall  register the Warrant  Shares
pursuant  to  Section 7 of the  Agreement.  In the event of the  failure  of the
Company to procure  registration  of the Warrant  Shares by the later of (i) the
Initial  Exercise  Date, as adjusted  pursuant to paragraph  11(c) above or (ii)
ninety (90) days from the Closing Date (as defined in the Agreement),  or during
a Suspension, as defined under the Agreement, the Company will pay to the Finder
by wire transfer,  as liquidated  damages for such failure and not as a penalty,
two (2%) percent of the product of the Exercise Price and the number of Warrants
that have not been  exercised,  for each of the first two (2)  months  and three
(3%)  percent  per  month  thereafter  that the  registration  statement  is not
effective or that such Suspension continues.  If not paid as required,  interest
on such damages  will accrue at a rate of 2% per month.  If the Company does not
remit the damages to the Finder as set forth  above,  the  Company  will pay the
Finder reasonable costs of collection,  including attorneys fees, in addition to
the liquidated damages.  Such payment shall be made to the Finder immediately if
the registration of the Warrant Shares is not effected and maintained; provided,
however,  that the  payment of such  liquidated  damages  shall not  relieve the
Company from its  obligations  to register the Warrant  Shares  pursuant to this
paragraph 12. The  registration of the Warrant Shares pursuant to this provision
shall not effect or limit Finder's other rights or remedies as set forth in this
Warrant.  The obligations of the Company under this paragraph 12 shall cease and
terminate  upon the  earlier  to occur  of (x) such  time as all of the  Warrant
Shares have been  re-sold or (y) such time as all of the  Warrant  Shares may be
re-sold pursuant to Rule 144(k) under the Securities Act.


     13.  Adjustments of Exercise Price and Number of Warrant Shares. The number
and kind of  securities  purchasable  upon the  exercise of this Warrant and the
Exercise  Price  shall be  subject  to  adjustment  from  time to time  upon the
happening of certain events, as hereinafter set forth:

     (a) In case the Company shall at any time subdivide its outstanding  shares
of Common Stock  ("Common  Shares")  into a greater  number of Common  Shares or
declare a dividend  or  distribution  upon its Common  Shares  payable in Common
Shares,  the Exercise Price in effect  immediately  prior to such subdivision or
declaration shall be proportionately  reduced,  and the number of Warrant Shares
issuable  upon  exercise of the  Warrants  shall be  proportionately  increased.
Conversely,  in case the  outstanding  Common  Shares  of the  Company


                                       4
<PAGE>

shall be combined into a smaller number of Common Shares,  the Exercise Price in
effect immediately prior to such combination shall be proportionately increased,
and the number of Warrant Shares issuable upon exercise of the Warrants shall be
proportionately reduced.

     (b) In case the Company shall issue rights,  options or warrants to holders
of its  outstanding  Common Stock  entitling  them (for a period  within 45 days
after the record date  mentioned  below) to subscribe for or purchase  shares of
Common Stock or securities  convertible  into or exchangeable or exercisable for
Common Stock at a Price Per Share (as defined in  paragraph  (d) below) which is
lower at the date of issuance  thereof  than the then  Current  Market Price (as
defined in  paragraph  (e) below)  per share of Common  Stock at such date,  the
number of Warrant Shares hereafter purchasable upon the exercise of this Warrant
shall be  determined by  multiplying  the number of Warrant  Shares  theretofore
purchasable upon exercise of this Warrant by a fraction,  of which the numerator
shall be the  number  of  shares  of  Common  Stock  outstanding  on the date of
issuance  of such  rights,  options or  warrants  plus the number of  additional
shares of Common Stock actually  subscribed for and purchased,  and of which the
denominator  shall be the number of shares of Common  Stock  outstanding  on the
date of issuance of such rights,  options or warrants  plus the number of shares
of Common Stock which the aggregate Proceeds (as defined in paragraph (d) below)
received by the Company on exercise of such rights,  options and warrants  would
purchase at the Current  Market  Price per share of Common  Stock at the date of
issuance of such rights,  options or  warrants.  Such  adjustment  shall be made
whenever such rights, options or warrants are issued, and shall become effective
on the date of distribution retroactive to the record date for the determination
of stockholders entitled to receive such rights, options or warrants.

     (c) In case the Company shall distribute to holders of its shares of Common
Stock  evidences  of  its  indebtedness  or  assets   (excluding   dividends  or
distributions referred to in paragraph (a) above or in the paragraph immediately
following this paragraph and excluding any dividend or distribution  paid out of
the  retained  earnings  of the  Company)  or rights,  options or  warrants,  or
convertible or exchangeable  securities containing the right to subscribe for or
purchase  shares of Common Stock  (excluding  those referred to in paragraph (b)
above),  then in each case the number of Warrant Shares  thereafter  purchasable
upon the exercise of this Warrant shall be determined by multiplying  the number
of Warrant Shares theretofore purchasable upon the exercise of this Warrant by a
fraction,  of which the  numerator  shall be the then  Current  Market Price per
share  of  Common  Stock  on the date of such  distribution,  and of  which  the
denominator  shall be such Current  Market  Price,  less the then fair value (as
determined  by the Board of  Directors  of the  Company)  of the  portion of the
assets or evidences  of  indebtedness  so  distributed  or of such  subscription
rights,  options or warrants, or of such convertible or exchangeable  securities
applicable to one share of Common Stock.  Such adjustment shall be made whenever
any such  distribution  is  made,  and  shall  become  effective  on the date of
distribution   retroactive  to  the  record  date  for  the   determination   of
shareholders entitled to receive such distribution.

                                       5
<PAGE>

     (d) For purposes of this Section 13, "Price Per Share" shall be defined and
determined according to the following formula:

                      R
             P = ------------
                      N

     where

             P =      Price Per Share,

             R =      the "Proceeds" received or receivable by the Company which
                      (i) in the case of  shares  of  Common  Stock is the total
                      amount   received   or   receivable   by  the  Company  in
                      consideration  for the sale and  issuance of such  shares;
                      (ii)  in the  case  of  rights,  options  or  warrants  to
                      subscribe  for or  purchase  shares of Common  Stock or of
                      securities convertible into or exchangeable or exercisable
                      for shares of Common Stock,  is the total amount  received
                      or receivable by the Company in consideration for the sale
                      and  issuance  of  such  rights,   options,   warrants  or
                      convertible or  exchangeable  or  exercisable  securities,
                      plus  the   minimum   aggregate   amount   of   additional
                      consideration,   other   than   the   surrender   of  such
                      convertible  or  exchangeable  securities,  payable to the
                      Company upon exercise, conversion or exchange thereof; and
                      (iii)  in the  case of  rights,  options  or  warrants  to
                      subscribe for or purchase  convertible or  exchangeable or
                      exercisable  securities,  is the total amount  received or
                      receivable  by the Company in  consideration  for the sale
                      and issuance of such rights, options or warrants, plus the
                      minimum aggregate amount of additional consideration other
                      than the  surrender of such  convertible  or  exchangeable
                      securities,  payable  upon  the  exercise,  conversion  or
                      exchange of such rights,  options or warrants and upon the
                      conversion or exchange or exercise of the  convertible  or
                      exchangeable or exercisable  securities;  provided that in
                      each  case the  proceeds  received  or  receivable  by the
                      Company  shall be  deemed to be the  gross  cash  proceeds
                      without  deducting  therefrom  any  compensation  paid  or
                      discount  allowed in the sale,  underwriting  or  purchase
                      thereof by  underwriters  or  dealers or other  performing
                      similar  services or any expenses  incurred in  connection
                      therewith,

     and

              N =     the  "Number of  shares,"  which (i) in the case of Common
                      Stock is the number of shares issued;  (ii) in the case of
                      rights,  options or warrants to subscribe  for or purchase
                      shares of Common Stock or of securities  convertible  into
                      or exchangeable or exercisable for shares of Common Stock,
                      is the maximum number of shares of Common Stock  initially

                                       6
<PAGE>

                      issuable upon  exercise,  conversion or exchange  thereof;
                      and (iii) in the case of rights,  options or  warrants  to
                      subscribe for or purchase  convertible or  exchangeable or
                      exercisable securities, is the maximum number of shares of
                      Common Stock initially issuable upon conversion,  exchange
                      or   exercise   of  the   convertible,   exchangeable   or
                      exercisable  securities issuable upon the exercise of such
                      rights, options or warrants.

     If the  Company  shall  issue  shares of Common  Stock or rights,  options,
warrants  or  convertible  or  exchangeable  or  exercisable  securities  for  a
consideration  consisting, in whole or in part, of property other than cash, the
amount of such  consideration  shall be determined in good faith by the Board of
Directors of the Company whose determination shall be conclusive.

     (e) For the purpose of any computation  under paragraphs (b), (c) or (d) of
this  Section 13, the  "Current  Market  Price" per share of Common Stock at any
date shall be the average of the Closing  NASDAQ  Price of the Common  Stock for
the thirty  (30)  trading  days  commencing  30 trading  days before the date of
determination.  If the Common Stock is not traded on Nasdaq,  the Current Market
Price shall be the average closing price (and if not available,  the mean of the
high and low prices) of the Common Stock on the  over-the-counter-market  or the
principal  national  securities  exchange or the National Market System on which
the Common  Stock is traded for the  thirty  (30)  trading  days  commencing  30
trading days before the date of determination.

     (f) Whenever the number of Warrant Shares  purchasable upon the exercise of
this Warrant is adjusted,  as herein  provided,  the Exercise Price payable upon
exercise of this Warrant shall be adjusted by  multiplying  such Exercise  Price
immediately prior to such adjustment by a fraction, of which the numerator shall
be the number of Warrant  Shares  purchasable  upon the exercise of this Warrant
immediately prior to such adjustment,  and of which the denominator shall be the
number of Warrant Shares purchasable immediately thereafter.

     (g) No adjustment  in the number of Warrant  Shares  purchasable  hereunder
shall be required unless such adjustment would result in an increase or decrease
of at least one percent (1%) percent of the Exercise  Price;  provided  that any
adjustments  which by reason of this  paragraph  (h) are not required to be made
shall be carried  forward and taken into account in any  subsequent  adjustment.
All  calculations  shall  be  made  to  the  nearest  cent  or  to  the  nearest
one-thousandth of a share, as the case may be.

     (h) No  adjustment  in the number of Warrant  Shares  purchasable  upon the
exercise of this  Warrant  need be made under  paragraph  (b), (c) or (d) if the
Company issues or distributes to the holder of this Warrant the shares,  rights,
options,  warrants or convertible or  exchangeable  securities,  or evidences of
indebtedness or assets referred to in those  paragraphs which the holder of this
Warrant  would have been  entitled to receive had this  Warrant  been  exercised
prior to the happening of such event or the record date with respect thereto. In
no  event


                                       7
<PAGE>

shall  the  Company  be  required  or  obligated  to make any such  distribution
otherwise  than in its sole  discretion.  No adjustment in the number of Warrant
shares  purchasable  upon the exercise of this Warrant need be made for sales of
Common  Stock  pursuant  to a Company  plan for  reinvestment  of  dividends  or
interest. No adjustment need be made for a change in the par value of the Common
Stock.

     (i) In the  event  that at any  time,  as a result  of an  adjustment  made
pursuant  to  paragraph  (a) above,  the  holder of this  Warrant  shall  become
entitled to purchase any  securities  of the Company other than shares of Common
Stock,  thereafter the number of such other shares so purchasable  upon exercise
of this  Warrant  and the  Exercise  Price of such  shares  shall be  subject to
adjustment  from time to time in a manner and on terms as nearly  equivalent  as
practicable  to the provisions  with respect to the Warrant Shares  contained in
paragraphs (a) through (i), inclusive, above.

     14. Voluntary  Adjustment by the Company. The Company may at its option, at
any time during the term of this Warrant, reduce the then current Exchange Price
to any  amount  and for any period of time  deemed  appropriate  by the Board of
Directors of the Company.

     15. Notice of  Adjustment.  Whenever the number of Warrant shares or number
or kind of securities or other  property  purchasable  upon the exercise of this
Warrant or the Exercise Price is adjusted, as herein provided, the Company shall
promptly mail by registered or certified mail, return receipt requested,  to the
transfer  agent for the Common Stock and to the holder of this Warrant notice of
such  adjustment or adjustments  setting forth the number of Warrant Shares (and
other securities or property)  purchasable upon the exercise of this Warrant and
the Exercise Price of such Warrant Shares after such adjustment, setting forth a
brief  statement  of the facts  requiring  such  adjustment  and  setting  forth
computation  by which  such  adjustment  was made.  Such  notice,  in absence of
manifest  error,  shall  be  conclusive  evidence  of the  correctness  of  such
adjustment.

     16.  Authorized  Shares.  The Company  covenants that during the period the
Warrant is outstanding,  it will reserve from its authorized and unissued Common
Stock a sufficient  number of shares to provide for the issuance of Common Stock
upon the exercise of any purchase rights under this Warrant. Such reservation of
shares of Common  Stock  shall be in addition  to those  shares of Common  Stock
reserved  pursuant to the Company's  Certificate of Designation for its Series B
Preferred Stock. The Company further covenants that its issuance of this Warrant
shall constitute full authority to its officers who are charged with the duty of
executing stock certificates to execute and issue the necessary certificates for
shares of the  Company's  Common Stock upon the exercise of the purchase  rights
under this Warrant.  The Company will take all such reasonable  action as may be
necessary  to assure that such shares of Common  Stock may be issued as provided
herein  without  violation  of  any  applicable  law  or  regulation,  or of any
requirements of NASDAQ or any domestic securities exchange upon which the Common
Stock may be listed.

                                       8
<PAGE>

     17.  Restrictions  on  Exercise.  Notwithstanding  anything to the contrary
contained  herein,  no  Warrants  may  be  converted  by a  holder  of  Warrants
("Holder") to the extent that, after giving effect to the shares of Common Stock
issued  pursuant to the  exercise  hereof,  the total number of shares of Common
Stock  deemed  beneficially  owned by such  Holder  (other than by virtue of the
ownership of shares of Series A Preferred  Stock or Series B Preferred  Stock or
Warrants or ownership of other  securities  that have  limitations on a Holder's
rights to convert or exercise  similar to those  limitations  set forth herein),
together with all shares of Common Stock deemed  beneficially  owned by Holder's
"affiliates"  (as  defined  in Rule  144  under  the  1933  Act)  that  would be
aggregated  for purposes of  determining  whether a group under Section 13(d) of
the Securities Exchange Act of 1934, as amended,  exists,  would exceed 4.99% of
the total issued and  outstanding  shares of Common  Stock,  provided  that each
Holder  shall  have the right to waive  this  restriction,  in whole or in part,
immediately  in case of a pending Change in Control  Transaction  (as defined in
the  Agreement)  and in any  other  case  upon 61  days  prior  to the  exercise
hereunder  by Holder.  The exercise of all or part of this Warrant by any Holder
shall be deemed a  representation  by such Holder it is in compliance  with this
Section 17. A transferee of Warrants shall not be bound by this provision unless
it expressly agrees to be so bound. The term "deemed beneficially owned" as used
in this  Section  17  shall  exclude  shares  that  might  otherwise  be  deemed
beneficially owned by reason of the exercisability of the Warrants.

     18. Miscellaneous.

     (a) Issue Date. The provisions of this Warrant shall be construed and shall
be given  effect in all  respects as if it had been issued and  delivered by the
Company on the date hereof. This Warrant shall be binding upon any successors or
assigns of the Company.  This Warrant shall constitute a contract under the laws
of New York and for all  purposes  shall be  construed  in  accordance  with and
governed  by the laws of said  state  without  regard  to its  conflict  of law,
principles or rules.

     (b)  Restrictions.  The holder  hereof  acknowledges  that the Common Stock
acquired  upon  the  exercise  of this  Warrant,  if not  registered,  may  have
restrictions upon its resale imposed by state and federal securities laws.

     (c) Modification and Waiver.  This Warrant and any provisions hereof may be
changed,  waived,  discharged  or  terminated  only by an  instrument in writing
signed by the party against which enforcement of the same is sought.

     (d) Notices. Any notice, request or other document required or permitted to
be given or delivered to the holders hereof or the Company shall be delivered or
shall be sent by certified or registered mail, postage prepaid,  or by overnight
courier or by  facsimile  to each such  holder at its address (or fax number) as
shown on the books of the  Company  or to the  Company  at the  address  (or fax
number) set forth in the Agreement.




                                       9
<PAGE>



     IN WITNESS  WHEREOF,  the Company has caused this Warrant to be executed by
its officers thereunto duly authorized.


Dated:  March 31, 1997

                                               PHARMOS CORPORATION



                                               By__________________________
                                                          Officer


                                       10
<PAGE>



                                 ASSIGNMENT FORM

                    (To assign the foregoing warrant, execute
                   this form and supply required information.
                    Do not use this form to purchase shares.)


     FOR VALUE RECEIVED,  the foregoing Warrant and all rights evidenced thereby
are hereby assigned to

_______________________________________________ whose address is ______________

________________________________________


________________________________________________________________________________


                                                     Dated: ______________, 199_



                Holder's Signature:       _____________________________

                Holder's Address:         _____________________________

                                          _____________________________


Signature Guaranteed:  ___________________________________________




NOTE: The signature to this  Assignment Form must correspond with the name as it
appears on the face of the Warrant,  without  alteration or  enlargement  or any
change whatsoever,  and must be guaranteed by a bank or trust company.  Officers
of  corporations  and  those  acting  in an  fiduciary  or other  representative
capacity  should  file  proper  evidence of  authority  to assign the  foregoing
Warrant.





                                       11
<PAGE>


                         [FORM OF ELECTION TO PURCHASE]

     The  undersigned   hereby   irrevocably   elects  to  exercise  the  right,
represented by this Warrant  Certificate,  to purchase  _____________  Shares of
Common Stock at an Exercise Price of $________________,  and herewith tenders in
payment for such  securities a certified check or official bank check payable in
New York Clearing House Funds to the order of Pharmos  Corporation in the amount
of $__________,  all in accordance with the terms of the Stock Purchase  Warrant
of Pharmos  Corporation,  dated March 31, 1997. The undersigned  requests that a
certificate    for   such    securities   be   registered   in   the   name   of
____________________   whose   address  is   _________________   and  that  such
Certificate    be   delivered    to    ________________    whose    address   is
__________________.

Dated:
                                    Signature __________________________________
                                    (Signature must conform in all respects to 
                                    name of holder as specified on the face of 
                                    the Warrant Certificate.)


                                    ____________________________________________
                                    (Insert Social Security or Other Identifying
                                     Number of Holder)


                                       12




                           March 4, 1998



Pharmos Corporation
33 Wood Avenue South, Suite 466
Iselin, New Jersey 08830

Ladies and Gentlemen:

We have  examined  the  Registration  Statement  on Form S-3 (the  "Registration
Statement") to be filed by you with the  Securities  and Exchange  Commission in
connection with the offer of the selling stockholder named therein (the "Selling
Stockholder") to sell from time to time up to 9,050,000 shares (the "Shares") of
the  Common  Stock,  par value  $.03 per  share,  of  Pharmos  Corporation  (the
"Company")  upon conversion of the Preferred Stock issued in connection with the
February  4,  1998  private  placement   transaction  (the  "Private   Placement
Transaction")  and up to  950,000  shares of the  Company's  Common  Stock  (the
"Warrant  Shares")  issuable  upon the  exercise of certain  warrants  issued in
connection with the Private Placement Transaction and 171,052 warrants issued by
the  Company in March  1997(collectively  the  "Warrants").  As your  counsel in
connection with the Private Placement  Transaction and the offer and sale of the
Shares and the issuance of the  Warrants,  we have  examined the  originals,  or
photostatic or certified copies, of such records of the Company, certificates of
the Company and of public  officials  and such other matters and documents as we
have deemed necessary or relevant as a basis for this opinion.

Based on these  examinations,  it is our opinion that the Shares and the Warrant
Shares,  when issued upon payment therefor,  will be validly issued,  fully paid
and non-assessable shares of Common Stock of the Company.

We  consent  to the  use of  this  opinion  as an  exhibit  to the  Registration
Statement  and further  consent to the  reference to this firm under the caption
"Legal Opinions" in the Prospectus forming a part of the Registration Statement.


         Very truly yours,

         EHRENREICH EILENBERG KRAUSE & ZIVIAN LLP

         /s/       Ehrenreich Eilenberg Krause & Zivian LLP




                       CONSENT OF INDEPENDENT ACCOUNTANTS



To the Board of Directors and
Shareholders of Pharmos Corporation

We  hereby  consent  to  the   incorporation  by  reference  in  the  Prospectus
constituting part of this Registration Statement on Form S-3 of our report dated
March 31, 1997 appearing in Pharmos Corporation's Annual Report on Form 10-K for
the year ended  December 31, 1996.  We also consent to the reference to us under
the heading "Experts" in such Prospectus.



 /s/ Price Waterhouse LLP

PRICE WATERHOUSE LLP
New York, New York
March 4, 1998




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