PHARMOS CORP
S-3, EX-4.E, 2000-09-28
PHARMACEUTICAL PREPARATIONS
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                                                                    EXHIBIT 4(e)

                            CERTIFICATE OF AMENDMENT
                                       OF
                       RESTATED ARTICLES OF INCORPORATION
                                       OF
                               PHARMOS CORPORATION
                              A Nevada Corporation

The undersigned hereby certify as follows:

     1. That they are the  President  and  Secretary,  respectively,  of Pharmos
Corporation, a Nevada Corporation (the "Corporation");

     2. That the original  Articles of  Incorporation  of the  Corporation  were
filed in the Office of the Secretary of State of the State of Nevada on the 20th
day of December, 1982;

     3. That the Restated  Articles of  Incorporation  of the  Corporation  were
filed in the Office of the Secretary of State of the State of Nevada on the 29th
day of October, 1992;

     4.  That  capital  has  been  paid to the  Corporation,  and  stock  of the
Corporation has been issued;

     5. That at a meeting of the Corporation's  Board of Directors (the "Board")
held  on May 7,  1999,  the  Board  unanimously  consented  to and  approved  an
amendment  (the  "Amendment")  to the first  paragraph of Article  FOURTH of the
Corporation's  Restated  Articles of Incorporation to increase the Corporation's
authorized capital stock to 80 million shares of Common Stock.

     6. That at a meeting of the Corporation's  stockholders held on October 13,
1999,  the  Corporation's  stockholders  voted  for  the  Amendment,  and  that,
therefore,  the first paragraph of Article FOURTH of the Corporation's  Restated
Articles of Incorporation is amended to read as follows:

          "FOURTH.  The total  number of shares of stock  which the  corporation
     shall have  authority  to issue is  eighty-one  million two  hundred  fifty
     thousand (81,250,000), of which stock eighty million (80,000,000) shares of
     the par value of three cents  ($0.03)  each,  amounting in the aggregate to
     Two Million Four Hundred  Thousand  Dollars  ($2,400,000),  shall be Common
     Stock,  and of which one  million two hundred  fifty  thousand  (1,250,000)
     shares of the par  value of three  cents  ($0.03)  each,  amounting  in the
     aggregate to Thirty-Seven Thousand Five Hundred Dollars ($37,500), shall be
     Preferred Stock."

<PAGE>

     IN WITNESS  WHEREOF,  the  undersigned  have executed this  Certificate  of
Amendment  of Restated  Articles of  Incorporation  on this 20th day of October,
1999.


                                        ------------------------
                                        Gad Riesenfeld
                                        President


                                        ------------------------
                                        Robert W. Cook
                                        Secretary



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