PHARMOS CORP
PRE 14A, 2000-05-25
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
                Proxy Statement Pursuant to Section 14(a) of the
                         Securities Exchange Act of 1934

Filed by the Registrant [X]
Filed by a Party other than the Registrant [_]

Check the appropriate box:

[X]  Preliminary Proxy Statement             [_] Confidential, For Use of the
[_]  Definitive Proxy Statement                  Commission Only (as permitted
[_]  Definitive Additional Materials             by Rule 14a-6(e)(2))
[_]  Soliciting Material Pursuant to
     Rule 14a-11(c) or Rule 14a-12


                              PHARMOS CORPORATION
    -----------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)


    -----------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)


Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.
[_] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.


- -----------------------------------------------------------------------
1) Title of each class of securities to which transaction applies:


- -----------------------------------------------------------------------
2) Aggregate number of securities to which transaction applies:


- -----------------------------------------------------------------------
3)   Per unit price or other underlying value of transaction  computed  pursuant
     to Exchange  Act Rule 0-11 (set forth the amount on which the filing fee is
     calculated and state how it was determined):


- -----------------------------------------------------------------------
4) Proposed maximum aggregate value of transaction:


- -----------------------------------------------------------------------
5) Total fee paid:

     [_] Fee paid previously with preliminary materials:


- -----------------------------------------------------------------------

     [_] Check box if any part of the fee is offset as provided by Exchange  Act
Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

     1)   Amount previously paid:

     2)   Form, Schedule or Registration Statement No.:

     3)   Filing Party:

     4)   Date Filed:

<PAGE>

                               PHARMOS CORPORATION
                         99 Wood Avenue South, Suite 301
                                Iselin, NJ 08830
                                 (732) 452-9556

                    ----------------------------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                    ----------------------------------------


     NOTICE IS HEREBY  GIVEN,  that the Annual  Meeting of the  Stockholders  of
Pharmos  Corporation (the "Company") will be held in Edison, New Jersey at 11:00
AM on July 20, 2000 at the Sheraton  Edison Hotel,  125 Raritan Center  Parkway,
(i) for the  election of  Directors of the Company to hold office until the next
annual meeting of the  stockholders  and until their successors are duly elected
and qualified;  (ii) to adopt the Company's 2000 Stock Option Plan; and (iii) to
transact  such other  business  as may  properly  come before the meeting or any
adjournment or adjournments thereof.

     The Board of Directors  has fixed the close of business on June 14, 2000 as
the record date for the determination of stockholders entitled to notice of, and
to vote at, the Annual Meeting.

     If you do not expect to be personally present at the meeting, but wish your
stock to be voted  for the  business  to be  transacted  thereat,  the  Board of
Directors  requests  that you fill in,  sign  and date the  enclosed  proxy  and
promptly return it by mail in the postage paid envelope provided.

                                            BY ORDER OF THE BOARD OF DIRECTORS


                                                     Haim Aviv, Ph.D.
                                                     Chairman of the Board

June 16, 2000


PLEASE COMPLETE,  SIGN AND DATE THE ENCLOSED PROXY AND PROMPTLY RETURN IT IN THE
ENVELOPE PROVIDED. NO POSTAGE IS NECESSARY IF MAILED IN THE UNITED STATES.



<PAGE>

                               PHARMOS CORPORATION
                         99 Wood Avenue South, Suite 301
                                Iselin, NJ 08830
                                 (732) 452-9556

                                 PROXY STATEMENT

                       FOR ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON JULY 20, 2000

                                  INTRODUCTION

     The Annual Meeting is called to elect members of the Board of Directors and
to adopt the Company's  2000 Stock Option Plan. The Meeting will be open for the
transaction of such other business as may properly come before it, although,  as
of the date of this  proxy  statement,  management  does  not know of any  other
business that will come before the Annual Meeting.  If any other matters do come
before the Annual  Meeting,  the persons named in the enclosed form of proxy are
expected to vote said proxy in accordance with their judgment on such matters.

     This proxy statement and the accompanying proxy card are first being mailed
on or about June 16, 2000 to  stockholders of record as of June 14, 2000. A copy
of the Annual Report for the fiscal year ended December 31, 1999, which includes
audited financial statements, is included herewith.

     The  solicitation  of proxies in the  accompanying  form is made by, and on
behalf of, the Board of Directors,  and no  compensation  will be paid therefor.
There  will be no  solicitation  of  proxies  other  than  by  mail or  personal
solicitation  by officers and  employees  of the Company.  The Company will make
arrangements   with  brokerage  houses  and  other   custodians,   nominees  and
fiduciaries  for the forwarding of proxy  material to the  beneficial  owners of
shares held of record by such persons,  and such persons will be reimbursed  for
reasonable  expenses  incurred by them in  connection  therewith.  A stockholder
executing the accompanying proxy has the power to revoke it at any time prior to
the exercise  thereof by filing with the  Secretary  of the Company:  (i) a duly
executed proxy bearing a later date; or (ii) a written  instrument  revoking the
proxy.

     With regard to the election of Directors,  votes may be cast in favor of or
withheld from each nominee. Abstention and "Broker Non-votes" (as defined below)
are  counted  for  purposes  of  determining  whether a quorum is present at the
Annual  Meeting,  but do not represent  votes cast with respect to any proposal.
"Broker  Non-votes" are shares held by a broker or nominee for which an executed
proxy is received by the  Company,  but which  shares are not voted as to one or
more proposals  because  instructions have not been received from the beneficial
owners or  persons  entitled  to vote and the  broker or  nominee  does not have
discretionary voting power.



<PAGE>

                                VOTING SECURITIES

     The Board of Directors  has fixed the close of business on June 14, 2000 as
the record date for the determination of stockholders entitled to notice of, and
to vote at, the Annual Meeting.

     As of May 1, 2000, the outstanding  capital stock of the Company  consisted
of 52,485,197 shares of Common Stock. Each holder of Common Stock is entitled to
one vote  for each  share of  Common  Stock  held by him or her at the  close of
business on the record date.

     The shares for which the  accompanying  proxy is solicited will be voted in
accordance  with the directions  given,  provided that the proxy is executed and
returned by the stockholder prior to the Annual Meeting.

     The  following  table sets forth  certain  information  with respect to the
beneficial  ownership of the Company's Common Stock as of March 15, 2000, except
as set forth in the  footnotes,  by (i) each person who was known by the Company
to own beneficially  more than 5% of any class of the Company's Stock, (ii) each
of the  Company's  Directors,  and (iii) all  current  Directors  and  executive
officers  of the  Company as a group.  Except as  otherwise  noted,  each person
listed  below has sole voting and  dispositive  power with respect to the shares
listed next to such person's name.

                                          Amount
Name and Address of                    of Beneficial               Percentage
Beneficial Owner                         Ownership                of Total (1)
- --------------------------             -------------              ------------

Haim Aviv, Ph.D.(2)                        1,248,805                   2.4%
c/o Pharmos Ltd.
Kiryat Weitzman
Rehovot, Israel

Marvin P. Loeb(3)                             35,656                     *
Trimedyne, Inc.
2810 Barranca Road
Irvine, CA  92714

E. Andrews Grinstead III(4)                  124,488                     *
Hybridon, Inc.
620 Memorial Drive
Cambridge, MA 02139


<PAGE>

David Schlachet                                   --                     *
Strauss Holdings Ltd.
16 Bazel Street
Petach-Tikva, Israel 49510

Mony Ben Dor                                      --                     *
The Israel Corporation
4 Weizman St.
Tel-Aviv 61336, Israel

Georges Anthony Marcel, M.D., Ph.D                --                     *
c/o TMC Development
9, rue de Magdebourg
75116 Paris France

Samuel D. Waksal, Ph.D.                        2,000                     *
c/o ImClone Systems Inc.
180 Varick Street, 6th Floor
New York, NY  10014

Elkan R. Gamzu, Ph.D.                             --                     *
Cambridge Neuroscience, Inc.
One Kendell Square
Cambridge, MA  02139

Stephen C. Knight, M.D.(5)                    25,000                     *
Epix Medical, Inc.
71 Rodgers Street
Cambridge, MA  02142

All Directors and                          1,597,632                    3.1%
Executive Officers
as a Group (11 People) (6)

- ----------

*    Indicates ownership of less than 1%.

(1)  Based  on  52,253,243  shares  of  Common  Stock  outstanding,   plus  each
     individual's  currently  exercisable  warrants or options.  Assumes that no
     other individual will exercise any warrants and/or options.

(2)  Includes 276,153 shares of Common Stock held in the name of Avitek Ltd., of
     which Dr. Aviv is the Chairman of the Board of Directors  and the principal
     stockholder,  and,  as such,  shares the right to vote and  dispose of such
     shares.  Also  includes  currently  exercisable  options  and  warrants  to
     purchase 411,876 shares of Common Stock.


<PAGE>

(3)  Held  jointly  with his wife.  Does not  include  shares  held by his adult
     children,   his   grandchildren   or  a  trust  for  the   benefit  of  his
     grandchildren.  Mr. Loeb is not standing for  re-election  as a Director of
     the Company.

(4)  Consists of currently  exercisable  options and warrants to purchase Common
     Stock.

(5)  Dr.  Knight  resigned as a Director  of the Company in April 2000.  At such
     time, all of his outstanding options and warrants were exercisable.

(6)  Based on the number of shares of Common  Stock  outstanding,  plus  710,947
     currently  exercisable  warrants  and  options  held by the  Directors  and
     executive  officers.  Does not include  warrants  and  options  held by Dr.
     Knight, who resigned from the Board in April 2000.

                         ITEM 1 - ELECTION OF DIRECTORS

     Seven  Directors  are to be elected at the  Annual  Meeting to hold  office
until the next annual meeting of  stockholders  and until their  successors have
been duly  elected  and  qualified.  The  election  of  Directors  requires  the
affirmative  vote of a plurality of shares cast of Common Stock voting  together
present or  represented at a meeting at which a quorum  (one-third  (1/3) of the
outstanding  shares of Common Stock) is present or  represented.  Abstention and
Broker  Non-votes  are counted for purposes of  determining  whether a quorum is
present, but do not represent votes cast with respect to any proposal. It is the
intention of the persons  named in the  accompanying  proxy form to vote FOR the
election  of the eight  persons  named in the table  below as  Directors  of the
Company,  unless  authority to do so is withheld.  Proxies cannot be voted for a
greater number of persons than the nominees  named. In the event that any of the
below listed  nominees for Director  should become  unavailable for election for
any presently  unforeseen  reason,  the persons named in the accompanying  proxy
form have the right to use their discretion to vote for a substitute.

     The following  table sets forth the name, age and position of each Director
and executive officer:

Name                           Age                    Position
- ----                           ---                    --------
Haim Aviv, Ph.D.                60           Chairman, Chief Executive Officer,
                                             Chief Scientist

Elkan R. Gamzu, Ph.D.           57           Director

E. Andrews Grinstead III        54           Director

Samuel D. Waksal, Ph.D.         51           Director

David Schlachet                 54           Director


<PAGE>

Mony Ben Dor                    54           Director

Georges Anthony  Marcel,
M.D., Ph.D.                     59           Director

Gad Riesenfeld, Ph.D.           56           President and Chief Operating
                                             Officer

Robert W. Cook                  45           Vice President Finance and Chief
                                             Financial Officer

     Haim Aviv, Ph.D., is Chairman, Chief Executive Officer, Chief Scientist and
a Director of the Company.  In 1990, he co-founded  Pharmos  Corporation,  a New
York corporation ("Old Pharmos"),  which merged into the Company in October 1992
(the "Merger"). Dr. Aviv also served as Chairman, Chief Executive Officer, Chief
Scientist  and a Director of Old Pharmos  prior to the Merger.  Dr. Aviv was the
co-founder in 1980 of Bio-Technology  General Corp.  ("BTG"),  a publicly-traded
company  engaged in the  development  of products  using  recombinant  DNA,  its
General Manager and Chief Scientist from 1980 to 1985, and a Director and Senior
Scientific  Consultant  until  August 1993.  Prior to that time,  Dr. Aviv was a
professor of molecular biology at the Weizmann Institute of Science. Dr. Aviv is
the principal stockholder of Avitek Ltd., a stockholder of the Company. Dr. Aviv
is also an officer  and/or  significant  stockholder  of several  privately held
Israeli biopharmaceutical and venture capital companies.

     E.  Andrews  Grinstead,  III, a Director  of the  Company  since  1991,  is
Chairman  of the  Board  and  Chief  Executive  Officer  of  Hybridon,  Inc.,  a
publicly-held biotechnology company. Mr. Grinstead joined Hybridon in 1991. From
1987 to  October  1990,  he was  Managing  Director  and Group  Head of the life
sciences  group at  PaineWebber,  Inc.  From  1986 to 1987,  Mr.  Grinstead  was
Managing  Director and Group Head of the life sciences  group at Drexel  Burnham
Lambert,  Inc. From 1984 to 1986, he was a Vice  President at Kidder,  Peabody &
Co.,  Inc.,  where he developed the life sciences  corporate  finance  specialty
group.  Prior to his  seven  years on Wall  Street,  Mr.  Grinstead  served in a
variety of operational  and executive  positions with Eli Lilly & Company,  most
recently as general  manager of  Venezuelan  Pharmaceutical,  Animal  Health and
Agricultural  Chemical  Operations.  Serves as a director  of  Meridian  Medical
Technologies,  Inc., a pharmaceutical and medical device company.  Mr. Grinstead
has served as a member of the Board of Trustees for the Albert B. Sabine Vaccine
Foundation,  a 501(c)(3)  charitable  foundation dedicated to disease prevention
since 1994, and on the Board of the  Massachusetts  Biotech  Counsel since 1997.
Mr.  Grinstead was appointed to the President's  Council of the National Academy
of Sciences and the  Institute of Medicine in 1992.  Mr.  Grinstead  received an
A.B. from Harvard College in 1967, a J.D. from the University of Virginia School
of Law in 1974 and an  M.B.A.  from the  Harvard  Graduate  School  of  Business
Administration in 1976.


<PAGE>

     Elkan R. Gamzu,  Ph.D., a Director of the Company since February 2000, is a
consultant to the biotechnology and pharmaceutical industries. Prior to becoming
a  consultant,  Dr.  Gamzu held a number of senior  executive  positions  in the
biotechnology  and  pharmaceutical  industries,  including  President  and Chief
Executive  Officer of Cambridge  Neuroscience,  Inc.  from 1994 until 1998.  Dr.
Gamzu also served as President and chief Operating Officer and Vice President of
Development for Cambridge Neuroscience,  Inc. from 1989 to 1994. Previously, Dr.
Gamzu  held a variety  of  senior  positions  with  Warner-Lambert  and  Hoffman
LaRoche, Inc.

     Samuel D. Waksal,  Ph.D.,  a Director of the Company since March 2000, is a
founder of ImClone Systems Incorporated and has been its Chief Executive Officer
and a Director  since August 1985 and President  since March 1987.  From 1982 to
1985,  Dr. Waksal was a member of the faculty of Mt. Sinai School of Medicine as
Associate  Professor of Pathology and Director of the Division of  Immunotherapy
within the Department of Pathology.  He has served as visiting  Investigator  of
the National Cancer  Institute,  Immunology  Branch,  Research  Associate of the
Department of Genetics,  Stanford University Medical School, Assistant Professor
of pathology at Tufts University School of Medicine and Senior Scientist for the
Tufts Cancer Research  Center.  Dr. Waksal was a scholar of the Leukemia Society
of America  from 1979 to 1984.  Dr.  Waksal  currently  serves on the  Executive
Committee of the New York Biotechnology  Association,  the Board of Directors of
Cadus Pharmaceutical Corporation and is Chairman of the New York Council for the
Humanities.

     David Schlachet,  a Director of the Company since December 1994, has served
as the Chairman of Elite  Industries  Ltd. from July 1997.  From January 1996 to
June 1997, Mr.  Schlachet  served as the Vice President of the Strauss Group and
Chief Executive  Officer of Strauss  Holdings Ltd. The Strauss Group is Israel's
largest privately owned food  manufacturer.  Mr. Schlachet was Vice President of
Finance and  Administration  at the  Weizmann  Institute  of Science in Rehovot,
Israel from 1990 to  December,  1995.  Mr.  Schlachet  was  responsible  for the
Institute's administration and financial activities, including personnel, budget
and finance,  funding,  investments,  acquisitions  and  collaboration  with the
industrial  and  business  communities.  From 1989 to 1990,  Mr.  Schlachet  was
President and Chief Executive Officer of YEDA Research and Development Co. Ltd.,
a marketing  and  licensing  company at the Weizmann  Institute of Science.  Mr.
Schlachet  is  a  Director  of  Taya   Investment   Company   Ltd.,  an  Israeli
publicly-held investment company.

     Mony Ben Dor, a Director of the Company since September 1997, has been Vice
President of The Israel  Corporations,  Ltd. since May 1997, and chairman of two
publicly  traded  subsidiaries:  H.L.  Finance  and  Leasing  and Albany  Bonded
International  Trade. He is also a director of a number of subsidiary  companies
of Israel  Chemicals  Ltd. From 1992 to 1997,  Mr. Ben Dor was Vice President of
Business  Development  for Clal  Industries  Ltd. (a subsidiary of Clal Israel),
which  is one of the  leading  investment  groups  in  Israel.  He was  actively
involved in the acquisition of companies  including Jaffora Ltd. and a portfolio
of pharmaceutical companies including Pharmaceutical Resources Inc. and Finetech
Ltd. He served as a director representing Clal Industries in all of the

<PAGE>

acquired  companies as well as other companies of Clal Industries.  Prior to his
position at Clal  Industries  Ltd., Mr. Ben Dor served as Business  Executive at
the Eisenberg Group of companies.

     Georges  Anthony  Marcel,  M.D.,  Ph.D.,  a Director of the  Company  since
September  1998, is President  and Chief  Executive  Officer of TMC  Development
S.A.,  a  biopharmaceutical  consulting  firm based in Paris,  France.  Prior to
founding TMC  Development in 1992, Dr. Marcel held a number of senior  executive
positions in the pharmaceutical  industry,  including Chief Executive Officer of
Amgen's French subsidiary,  Vice President of Marketing for Rhone-Poulenc  Sante
and Director of Development for Roussel-Uclaf.  Dr. Marcel teaches biotechnology
industrial issues and European  regulatory  affairs at the Faculties of Pharmacy
of Paris and Lille.  Dr.  Marcel is also a member of the Gene  Therapy  Advisory
Committee at the French Medicines Agency.

     Gad Riesenfeld,  Ph.D., was named President and Secretary in February 1997,
and has  served  as Chief  Operating  Officer  since  March  1995.  He served as
Executive Vice President from December 1994 to February 1997,  Vice President of
Corporate  Development  and General  Manager of Florida  Operations from October
1992 to December 1994, and was employed by Old Pharmos from March 1992 until the
Merger.  Prior  thereto,  he was engaged in a variety of consulting  engagements
relating to the  commercialization  of intellectual  property,  primarily in the
pharmaceutical  and  medical  fields.  From  March  1990  through  May  1991 Dr.
Riesenfeld  was a  Managing  Director  of  Kamapharm  Ltd.,  a  private  company
specializing  in human blood  products.  Prior  thereto,  from May 1986,  he was
Managing  Director  of  Galisar  Ltd.,  a  pharmaceutical  company  involved  in
extracorporeal  blood  therapy.  Dr.  Riesenfeld  holds a Ph.D.  degree from the
Hebrew  University  of  Jerusalem  and  held  a  scientist  position,  as a post
doctorate  candidate,  at the  Cedars  Sinai  Medical  Center  in  Los  Angeles,
California.

     Robert W. Cook was  elected  Vice  President  Finance  and Chief  Financial
Officer of Pharmos in January 1998.  From May 1995 until his  appointment as the
Company's  Chief  Financial  Officer,  he was a vice  president  in GE Capital's
commercial finance subsidiary, based in New York. From 1977 until 1995, Mr. Cook
held a variety of corporate  finance and capital markets  positions at The Chase
Manhattan Bank, both in the U.S. and in several overseas locations. He was named
a  managing  director  of Chase in  January  1986.  Mr.  Cook  holds a degree in
international finance from The American University, Washington, D.C.

                   BOARD OF DIRECTORS MEETINGS AND COMMITTEES

     During  the 1999  fiscal  year,  there were four  meetings  of the Board of
Directors.  Each person who served as a director  in 1999  attended in excess of
75% of the  aggregate  of (i) the  total  number  of  meetings  of the  Board of
Directors  held  during 1999 and (ii) the total  number of meetings  held during
1999 by each committee of the Board of Directors

<PAGE>

on which such  director  served,  except  Marvin  Loeb,  who was absent from the
meeting of the Audit Committee.

     The members of the Audit Committee in 1999 were David  Schlachet,  Mony Ben
Dor and Marvin Loeb. The Audit  Committee met once in 1999. The Audit  Committee
has been delegated the responsibility of reviewing with the independent auditors
the plans and results of the audit engagement, reviewing the adequacy, scope and
results of the internal accounting controls and procedures, reviewing the degree
of independence of the auditors,  reviewing the auditor's fees and  recommending
the engagement of the auditors to the full Board of Directors.

     In 1999,  the  Compensation  and Stock  Option  Committee  consisted  of E.
Andrews Grinstead,  III, and Stephen C. Knight.  Actions of the Compensation and
Stock  Option  Committee  were taken  during the year by the  unanimous  written
consent of the Directors.  The  Compensation  and Stock Option Committee has the
full  power  and  authority  to  interpret  the  provisions  and  supervise  the
administration  of the Company's stock option plans and to grant options outside
of these plans and the authority to review all matters  relating to personnel of
the Company.

     The Board of Directors does not have a standing nominating committee.


                           SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                     Annual Compensation                        Long Term Compensation
                                ------------------------------                 -------------------------
                                                                                              Stock
Name/                                                                          Restricted     Underlying
Principal Position              Year     Salary        Bonus       Other       Stock          Options
- ----------------------          ----     ------        -----       ------      ----------     ----------
<S>                             <C>      <C>           <C>         <C>          <C>           <C>
Haim Aviv, Ph.D
Chairman, Chief                 1999     $236,418      $29,906     $ 2,829(1)                  65,000
Executive Officer, and          1998     $236,347                  $ 4,197(1)                 100,000
Chief Scientist                 1997     $227,471      $40,000     $16,119(1)

Gad Riesenfeld, Ph.D
President and                   1999     $185,000      $20,000     $53,860(2)                  50,000
Chief Operating Officer         1998     $175,000      $25,000     $50,728(2)                  80,000
                                1997     $175,000                  $44,948(2)

Robert W. Cook                  1999     $175,000      $20,000     $ 4,800(1)                  40,000
Vice President Finance          1998     $165,000      $20,000     $ 4,800(1)                 150,000
and Chief Financial Officer
</TABLE>

(1)  Consists of  contributions  to insurance  premiums,  car  allowance and car
     expenses.

(2)  Consists of housing allowance, contributions to insurance premiums, and car
     allowance.


The following  tables set forth  information with respect to the named executive
officers concerning the grant, repricing and exercise of options during the last
fiscal year and unexercised options held as of the end of the fiscal year.



<PAGE>

               OPTION GRANTS FOR THE YEAR ENDED DECEMBER 31, 1999:

                         Common Stock     % of Total
                         Underlying       Options        Exercise
                         Options          Granted to     Price        Expiration
                         Granted          Employees      per Share    Date
                         ------------     -----------    ---------    ----------

Haim Aviv, Ph.D          65,000           20.8%          $1.25        4/16/09

Gad Riesenfeld, Ph.D.    50,000           16.0%          $1.25        4/16/09

Robert W. Cook           40,000           12.8%          $1.25        4/16/09


                           AGGREGATED OPTION EXERCISES
                      FOR THE YEAR ENDED DECEMBER 31, 1999
                   ANS OPTION VALUES AS OF DECEMBER 31, 1999:

<TABLE>
<CAPTION>
                                                                                                      Value of Unexercised
                                Number of                         Number of Unexercised             In-the-Money Options at
                                 Shares                       Options at December 31, 1999             December 31, 1999
                               Acquired on         Value      -----------------------------     -----------------------------
Name                            Exercise         Realized     Exercisable     Unexercisable     Exercisable     Unexercisable
- ----                           -----------       --------     -----------     -------------     -----------     -------------
<S>                                 <C>              <C>        <C>              <C>              <C>              <C>
Haim Aviv, Ph.D                     0                0          349,376          140,000          $13,110          $  --

Gad Riesenfeld, Ph.D                0                0           99,333          110,000          $ 8,740          $  --

Robert W. Cook                      0                0           62,500          127,500          $ 7,800          $ 7,800
</TABLE>


                        REPORT OF COMPENSATION COMMITTEE

     The following  report of the  Compensation  Committee is provided solely to
the  shareholders  of the Company  pursuant to the  requirements of Schedule 14A
promulgated  under the Securities  Exchange Act of 1934, and shall not be deemed
to be "filed" with the  Securities  and Exchange  Commission  for the purpose of
establishing  statutory  liability.  This  Report  shall  not  be  deemed  to be
incorporated by reference in any document  previously or subsequently filed with
the Securities and Exchange Commission that incorporates by reference all or any
portion of this Proxy Statement.

     The  Compensation  and Stock  Option  Committee  of the Board of  Directors
establishes the general  compensation  policies of the Company, the compensation
plans and specific  compensation levels for executive officers,  and administers
the 1997 Incentive and Non-Qualified  Stock Option Plan as well as the Company's
other Stock  Option  Plans.  The  Compensation  and Stock  Option  Committee  is
composed of two  independent,  non-employee  Directors who have no  interlocking
relationships as defined by the Securities and Exchange Commission other than as
described   below  (see   "Compensation   Committee   Interlocks   and   Insider
Participation").

     The  Compensation  and  Stock  Option  Committee,   being  responsible  for
overseeing and approving executive  compensation and grants of stock options, is
in  a  position  to   appropriately   balance  the  current  cash   compensation
considerations   with  the   longer-range   incentive-oriented   growth  outlook
associated with stock options. The main objectives of the Company's compensation
structure  include rewarding  individuals for their respective  contributions to
the Company's  performance,  establishing executive

<PAGE>

officers  with a stake in the  long-term  success of the Company  and  providing
compensation   policies  that  will  attract  and  retain  qualified   executive
personnel.

     The  Compensation  and  Stock  Option  Committee  believes  that the  chief
executive  officer's (CEO) compensation  should be heavily influenced by Company
performance.  Although  Dr.  Aviv's  existing  agreements  with the Company (see
"Employment/Consulting  Contracts/Directors'  Compensation")  provide for a base
level of salary  and  consulting  compensation,  the  Committee  determines  the
appropriate  level of  bonuses  and  increases,  if any,  based in large part on
Company  performance.  The  Committee  also  considers  the  salaries of CEOs of
comparably-sized  companies and their performance.  Stock options are granted to
the CEO, as to other executives,  primarily based on the executive's  ability to
influence the Company's long-term growth.

     The  Compensation  and Stock Option  Committee has adopted similar policies
with respect to  compensation  of other  officers of the Company.  The Committee
establishes  base  salaries  that are within the range of  salaries  for persons
holding positions of similar responsibility at other companies. In addition, the
Committee   considers  factors  such  as  relative  Company   performance,   the
executive's  past  performance  and future  potential in  establishing  the base
salaries of executive officers.

     As with the CEO,  the number of options  granted to the other  officers  is
determined by the subjective  evaluation of the executive's ability to influence
the  Company's  long-term  growth.  All  options are granted at no less than the
current market price.  Since the value of an option bears a direct  relationship
to the  Company's  stock  price,  it is an effective  incentive  for managers to
create value for stockholders. The Committee therefore views stock options as an
important component of its long-term, performance-based compensation philosophy.


                                           Members of the Compensation and
                                           Stock Option Committee

                                           E. Andrews Grinstead, III
                                           Stephen C. Knight


EMPLOYMENT/CONSULTING CONTRACTS/DIRECTORS' COMPENSATION

     Haim Aviv,  Ph.D. In addition to serving as Chairman of the Board and Chief
Executive  Officer of the  Company,  Dr. Aviv has provided  consulting  services
under a consulting  agreement with an initial three-year term ended May 3, 1993.
The term automatically  renews for additional one-year periods unless either the
Company  or Dr.  Aviv  terminates  the  agreement  at least  90 days  prior to a
scheduled expiration date. The agreement has been renewed on an annual basis and
presently expires on May 3, 2001. Dr. Aviv is entitled to severance pay equal to
25% of his salary in the event of  termination  or  non-renewal  without  cause.
Under the agreement,  Dr. Aviv is required to

<PAGE>

render certain consulting services to the Company and in consideration therefor,
Dr. Aviv is entitled to receive  $170,000 per year,  subject to yearly increases
and review.

     The  Company's  subsidiary,  Pharmos  Ltd.,  employs  Dr. Aviv as its Chief
Executive Officer under an employment  agreement with Dr. Aviv pursuant to which
Dr. Aviv receives $66,000 per year,  subject to yearly increases and review. Dr.
Aviv is required to devote at least 50% of his  business  time and  attention to
the business of Pharmos,  Ltd. and to serve on its Board of Directors.  In March
2000, Dr. Aviv's base aggregate  compensation of $236,000 per year was increased
by 5% to an aggregate of $247,800 effective January 1, 2000.

     Gad Riesenfeld,  Ph.D. In October 1992, Old Pharmos entered into a one-year
employment agreement with Dr. Riesenfeld,  which is automatically  renewable for
successive one-year terms unless either party gives three months prior notice of
non-renewal.  Under  the  Agreement,  Dr.  Riesenfeld  devotes  his full time to
serving  as  President  and  Chief  Operating   Officer  of  the  Company.   Dr.
Riesenfeld's  annual  gross  salary in 1999 was  $185,000.  In March  2000,  Dr.
Riesenfeld's  base  compensation  of $185,000  was  increased  by 5% to $194,250
effective January 1, 2000.

     Robert W. Cook.  In  January  1998,  the  Company  entered  into a one-year
employment  agreement  with Mr.  Cook,  which  is  automatically  renewable  for
successive one-year terms unless either party gives three months prior notice of
non-renewal.  Under the Agreement,  Mr. Cook devotes his full time to serving as
Vice President  Finance and Chief Financial  Officer of the Company.  Mr. Cook's
annual  gross  salary in 1999 was  $175,000.  In March  2000,  Mr.  Cook's  base
compensation of $175,000 was increased by 5% to $183,750,  effective  January 1,
2000.

     Elkan  R.  Gamzu,  Ph.D.  In  January  2000,  the  Company  entered  into a
consulting  agreement  with  Dr.  Gamzu  with a term  of one  year  (subject  to
extension by written agreement of the Company and Dr. Gamzu),  pursuant to which
Dr. Gamzu may provide certain assistance and consulting  services to the Company
as and when needed.  The agreement provides for compensation on a per diem basis
in connection with the provision of such  assistance and consulting  services at
the rate of $3,000 per day. As of May 1, 2000,  an aggregate  of  $8,255.25  had
been paid to Dr. Gamzu pursuant to the consulting agreement.

     Directors'   Compensation.   In  1999,   Directors   did  not  receive  any
compensation for service on the Board or for attending Board meetings.


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The members of the  Compensation and Stock Option Committee in 1999 were E.
Andrews Grinstead,  III, and Stephen C. Knight.  There were no interlocks on the
Compensation and Stock Option Committee in 1999.

                                PERFORMANCE GRAPH

     The following graph compares the Company's cumulative stock-holder's return
for the five year  period  ended  December  31, 1999 with the  cumulative  total
return of the

<PAGE>

NASDAQ  Equity Market Index and the NASDAQ  Pharmaceuticals  Index over the same
period.

                      COMPARISON OF CUMULATIVE TOTAL RETURN

 [THE FOLLOWING TABLE WAS REPRESENTED AS A LINE GRAPH IN THE PRINTED MATERIAL]

                           1994      1995     1996     1997     1998     1999
                           ----      ----     ----     ----     ----     ----

Nasdaq Composite           100.00   141.33   173.89   213.07   300.25   542.43

Nasdaq Pharmaceuticals     100.00   183.41   183.98   189.98   241.68   451.62

Pharmos Corporation        100.00   107.07   107.07   145.77   116.18   157.14


                TRANSACTIONS AND/OR INDEBTEDNESS WITH MANAGEMENT

     None.


                               SECTION 16 FILINGS

     No person  who,  during the fiscal  year ended  December  31,  1999,  was a
director,  officer or beneficial owner of more than ten percent of the Company's
Common Stock, a "Reporting  Person",  failed to file on a timely basis,  reports
required by Section 16 of the Securities Exchange Act of 1934 (the "Act") during
the most recent fiscal year.  The foregoing is based solely upon a review by the
Company of Forms 3 and 4 during the most recent  fiscal year as furnished to the
Company under Rule 16a-3(d)  under the Act, and Forms 5 and  amendments  thereto
furnished to the Company with  respect to its most recent  fiscal year,  and any
representation  received by the Company from any reporting person that no Form 5
is required.

              ITEM 2 - PROPOSAL TO ADOPT THE 2000 STOCK OPTION PLAN

     The Company's  1983,  1984, 1986 and 1988 Incentive Stock Option Plans (the
"Incentive  Plans"),  which are virtually  identical,  provide for the issuance,
pursuant to the exercise of stock options granted thereunder, of an aggregate of
225,000 shares of Common Stock.  The Company's  Non-Qualified  Stock Option Plan
(the "Non-Qualified  Plan"),  which was approved by the Directors,  provides for
the issuance,  pursuant to the exercise of stock options under the Non-Qualified
Plan, of a maximum of 175,000  shares of Common Stock.  The Company's 1991 Stock
Option  Plan  (the  "1991  Plan"),  adopted  by Old  Pharmos,  provides  for the
issuance,  pursuant to the exercise of stock options  granted  thereunder,  of a
maximum of 56,062 shares of Common Stock.  The Company's  1992 Stock Option Plan
(the "1992 Plan")  provides for the issuance,  pursuant to the

<PAGE>

exercise of stock options granted thereunder,  of a maximum of 750,000 shares of
Common  Stock.  The  Company's  1997 Stock  Option  Plan,  as amended (the "1997
Plan"),  provides for the  issuance,  pursuant to the exercise of stock  options
granted thereunder,  of a maximum of 1,500,000 shares of Common Stock. Incentive
Stock  Options may only be granted to employees  of the  Company.  Non-Qualified
Stock Options may be granted to employees, Directors,  consultants, advisers and
contractors of the Company.  The Incentive  Plans, the  Non-Qualified  Plan, the
1991 Plan, the 1992 Plan and the 1997 Plan are sometimes  collectively  referred
to herein as the "Prior Plans".

     The Board of Directors has adopted,  subject to stockholder  approval,  the
2000 Stock  Option Plan ("2000  Plan")  which,  in most  material  respects,  is
similar to the Prior Plans.  The annual meeting will consider whether to approve
the 2000 Plan.  The full text of the 2000 Plan is  appended  to this Joint Proxy
Statement as Appendix A, and the following  summary is qualified in its entirety
by reference to the 2000 Plan.

     The purpose of the 2000 Plan is to allow employees,  outside  Directors and
consultants of the Company and its  subsidiaries  to increase their  proprietary
interest  in, and to  encourage  such  employees  to remain in the employ of, or
maintain their  relationship  with,  such entities.  It is intended that options
granted under the 2000 Plan will qualify either as incentive stock options under
Section 422 of the Code or as non-qualified  options.  Options granted under the
2000 Plan will only be exercisable for Common Stock.

     The 2000 Plan will be administered by a committee appointed by the Board of
Directors  (the   "Compensation   Committee")  or  by  the  Board  itself.   The
Compensation Committee will designate the persons to receive options, the number
of shares  subject to the options and the terms of the  options,  including  the
option price and the duration of each option, subject to certain limitations.

     The maximum  number of shares of Common Stock  available for issuance under
the 2000 Plan is 1,500,000  shares,  subject to adjustment in the event of stock
splits,  stock dividends,  mergers,  consolidations  and the like.  Common Stock
subject to options  granted  under the 2000 Plan that expire or  terminate  will
again be available for options to be issued under the 2000 Plan.

     The price at which shares of Common Stock may be purchased upon exercise of
an  incentive  stock  option must be at least 100% of the fair  market  value of
Common  Stock on the date the option is granted (or at least 110% of fair market
value in the case of a person holding more than 10% of the outstanding shares of
Common Stock (a "10% Stockholder")).

     The  aggregate  fair  market  value  (determined  at the time the option is
granted)  of Common  Stock with  respect to which  incentive  stock  options are
exercisable  for the first time in any  calendar  year by an optionee  under the
2000 Plan or any other  plan of the  Company or a  subsidiary,  shall not exceed
$100,000.  The  Compensation  Committee will fix the time or times when, and the
extent to  which,  an option is  exercisable,  provided  that no option  will be
exercisable  earlier  than one year or later  than ten  years  after the

<PAGE>

date of grant (or five years in the case of a 10% Stockholder). The option price
is payable in cash or by check. In addition,  the Board of Directors may grant a
loan to an employee,  pursuant to the loan  provision of the 2000 Plan,  for the
purpose of  exercising  an option or may  permit the option  price to be paid in
shares of Common Stock at the then current fair market value,  as defined in the
2000 Plan.

     Subject to the terms of the 2000 Plan,  the Board of  Directors at its sole
discretion shall determine when an option shall expire. A stock option agreement
may  provide  for  expiration  prior to the end of its term in the  event of the
termination  of the  optionee's  service  to the  Company  or death or any other
circumstances.

     The 2000 Plan  provides  that  outstanding  options  shall  vest and become
immediately  exercisable in the event of a "sale" of the Company,  including (i)
the  sale of more  than  75% of the  voting  power  of the  Company  in a single
transaction  or a series of  transactions,  (ii) the sale of  substantially  all
assets of the Company,  (iii) approval by the stockholders of a  reorganization,
merger or  consolidation,  as a result of which the  stockholders of the Company
will own less  than  50% of the  voting  power  of the  reorganized,  merged  or
consolidated company.

     The Board of Directors may amend, suspend or discontinue the 2000 Plan, but
it must obtain stockholder approval to (i) increase the number of shares subject
to the 2000 Plan or (ii) change the designation of the class of persons eligible
to receive options.

     Under current  federal income tax law, the grant of incentive stock options
under the 2000 Plan will not result in any taxable income to the optionee or any
deduction  for the  Company at the time the options are  granted.  The  optionee
recognizes  no gain upon the exercise of an option.  However the amount by which
the fair  market  value of  Common  Stock at the time the  option  is  exercised
exceeds the option price is an "item of tax  preference" of the optionee,  which
may cause the  optionee  to be subject to the  alternative  minimum  tax. If the
optionee  holds the shares of Common Stock received on exercise of the option at
least one year from the date of  exercise  and two years from the date of grant,
he will be taxed at the time of sale at long-term  capital gains rates,  if any,
on the amount by which the proceeds of the sale exceed the option price.  If the
optionee  disposes of the Common  Stock before the  required  holding  period is
satisfied,  ordinary  income will  generally be recognized in an amount equal to
the excess of the fair market value of the shares of Common Stock at the date of
exercise  over the option  price,  or, if the  disposition  is a taxable sale or
exchange,  the amount of gain realized on such sale or exchange if that is less.
If, as permitted by the 2000 Plan, the Board of Directors permits an optionee to
exercise an option by delivering  already owned shares of Common Stock valued at
fair  market  value) the  optionee  will not  recognize  gain as a result of the
payment of the option price with such already  owned  shares.  However,  if such
shares were acquired  pursuant to the previous  exercise of an option,  and were
held less than one year after  acquisition  or less than two years from the date
of grant, the exchange will constitute a disqualifying  disposition resulting in
immediate  taxation of the gain on the already owned shares as ordinary  income.
It is not clear  how the gain  will be  computed  on the  disposition  of shares
acquired by payment with already owned shares.


<PAGE>

     The Company from time to time engages in  discussions  with  pharmaceutical
and   biotechnology   companies   about   potential   business   and/or  product
consolidations,   joint  ventures,  acquisitions,   mergers  or  other  business
combinations.  If any such  transaction  is ever  consummated,  the existence of
these  additional  outstanding  stock options under the 2000 Plan could have the
effect of reducing the aggregate consideration received by existing stockholders
in such transaction.

     The  affirmative  vote of a plurality of shares cast of Common Stock voting
together present or represented at a meeting at which a quorum  (one-third (1/3)
of the outstanding  shares of Common Stock) is required for approval of the 2000
Plan.  Abstention  and Broker  Non-votes are counted for purposes of determining
whether a quorum is present, but do not represent votes cast with respect to any
proposal.  The Board of Directors  believes that, in the competitive  market for
highly qualified  personnel,  it is critical for companies to offer a variety of
benefits in order to attract,  retain and motivate key employees of  outstanding
ability.  Accordingly,  the Board of Directors recommends a vote FOR adoption of
the 2000 Plan.  Unless  they are  otherwise  directed by the  stockholders,  the
proxies intend to vote FOR this proposal.

     THE BOARD OF  DIRECTORS  UNANIMOUSLY  RECOMMENDS A VOTE FOR THE ADOPTION OF
THE 2000 STOCK OPTION PLAN (ITEM 2 ON THE ENCLOSED PROXY CARD).

                         INDEPENDENT PUBLIC ACCOUNTANTS

     The Company has appointed  PricewaterhouseCoopers as its independent public
accountants  to examine the financial  statements of the Company for the current
fiscal year. The selection of  PricewaterhouseCoopers  was approved by the Board
of Directors prior to their appointment.  PricewaterhouseCoopers has advised the
Company  that  they do not have any  material  financial  interests  in,  or any
connection with (other than as independent auditors, tax advisors and management
consultants), the Company.

     PricewaterhouseCoopers  is expected to be present at the Annual Meeting and
will have the opportunity to make a statement, if they desire to do so, and they
are expected to be available to respond to appropriate questions.

                        STOCKHOLDERS' PROPOSALS FOR 2001
                         ANNUAL MEETING OF STOCKHOLDERS

     Proposals which  stockholders  intend to present at the 2001 annual meeting
of stockholders  must be received by the Company by April 1, 2001 to be eligible
for inclusion in the proxy material for that meeting.


<PAGE>

                           ANNUAL REPORT ON FORM 10-K

     Upon  sending a written  request to  Pharmos  Corporation,  99 Wood  Avenue
South,  Suite 301,  Iselin,  NJ 08830,  Attention:  President,  stockholders may
obtain,  free of charge,  a copy of the Company's Annual Report on Form 10-K for
the fiscal year ended December 31, 1999, and any  amendments  thereto,  as filed
with the Securities and Exchange Commission.

                                  OTHER MATTERS

     As of the date of this Proxy Statement,  the only business which management
expects to be considered at the Annual  Meeting is the election of Directors and
the adoption of the 2000 Stock Option Plan. If any other matters come before the
meeting,  the persons  named in the enclosed  form of proxy are expected to vote
the proxy in accordance with their best judgment on such matters.

                                       BY ORDER OF THE BOARD OF DIRECTORS
                                                   HAIM AVIV, PH.D.
                                                   Chairman of the Board

Dated: June 16, 2000



<PAGE>

                                                                      APPENDIX A

                               PHARMOS CORPORATION


                             2000 STOCK OPTION PLAN


                            ADOPTED ON MARCH 28, 2000

<PAGE>


SECTION 1.         Establishment And Purpose...................................1


SECTION 2.         Administration..............................................1


SECTION 3.         Eligibility.................................................1


SECTION 4.         Stock Subject To Plan.......................................1


SECTION 5.         Terms And Conditions Of Options.............................2


SECTION 6.         Payment For Shares..........................................4


SECTION 7.         Adjustment Of Shares........................................4


SECTION 8.         Securities Law Requirements.................................6


SECTION 9.         No Retention Rights.........................................6


SECTION 10.        Duration and Amendments.....................................6


SECTION 11.        Definitions.................................................7


SECTION 12.        Execution...................................................9

                                       i

<PAGE>

                       PHARMOS CORPORATION 2000 STOCK PLAN

SECTION 1. Establishment And Purpose.

     The purpose of the Plan is to offer selected  individuals an opportunity to
acquire a  proprietary  interest in the success of the  Company,  or to increase
such  interest,  through  the  granting  of  Options to  purchase  Shares of the
Company's Stock. Options granted under the Plan may include Nonstatutory Options
as well as ISOs intended to qualify under Section 422 of the Code.

         Capitalized terms are defined in Section 11.

SECTION 2. Administration.

     (a) Committees of the Board of Directors.  The Plan may be  administered by
one or more  Committees.  Each Committee shall consist of one or more members of
the Board of Directors who have been  appointed by the Board of Directors.  Each
Committee shall have such authority and be responsible for such functions as the
Board of Directors has assigned to it. If no Committee has been  appointed,  the
entire Board of Directors shall  administer the Plan. Any reference to the Board
of Directors in the Plan shall be construed as a reference to the  Committee (if
any) to whom the Board of Directors has assigned a particular function.

     (b) Authority of the Board of Directors.  Subject to the  provisions of the
Plan,  the Board of Directors  shall have full  authority and discretion to take
any actions it deems necessary or advisable for the  administration of the Plan.
All decisions, interpretations and other actions of the Board of Directors shall
be final and binding on all Optionees and all persons deriving their rights from
an Optionee.

SECTION 3. Eligibility.

     Only Employees, Outside Directors and Consultants shall be eligible for the
grant of Options or the direct award or sale of Shares.  Only Employees shall be
eligible for the grant of ISOs.

SECTION 4. Stock Subject To Plan.

     (a) Basic  Limitation.  Shares offered under the Plan may be authorized but
unissued Shares or treasury  Shares.  The aggregate number of Shares that may be
issued  under the Plan  (either  directly  or upon  exercise of Options or other
rights to  acquire  Shares)  shall  not  exceed  1,500,000  Shares,  subject  to
adjustment  pursuant  to  Section 7. The  number of Shares  that are  subject to
Options or other rights  outstanding at any time under the Plan shall not exceed
the number of Shares that then remain available for issuance under the Plan. The
Company, during

                                       1

<PAGE>

the term of the Plan,  shall at all times reserve and keep available  sufficient
Shares to satisfy the requirements of the Plan.

     (b) Additional  Shares.  In the event that any outstanding  Option or other
right for any reason expires or is canceled or otherwise terminated,  the Shares
allocable to the  unexercised  portion of such Option or other right shall again
be available for the purposes of the Plan. In the event that Shares issued under
the Plan are  reacquired by the Company  pursuant to any  forfeiture  provision,
right of  repurchase  or right of first  refusal,  such  Shares  shall  again be
available  for the  purposes of the Plan,  except that the  aggregate  number of
Shares  which may be issued upon the  exercise of ISOs shall in no event  exceed
1,500,000 Shares (subject to adjustment pursuant to Section 7).

SECTION 5. Terms And Conditions Of Options.

     (a) Stock Option Agreement. Each grant of an Option under the Plan shall be
evidenced by a Stock Option Agreement between the Optionee and the Company. Such
Option shall be subject to all  applicable  terms and conditions of the Plan and
may be subject to any other terms and conditions which are not inconsistent with
the Plan and which the Board of Directors  deems  appropriate for inclusion in a
Stock Option  Agreement.  The provisions of the various Stock Option  Agreements
entered into under the Plan need not be identical.

     (b) Number of Shares Each Stock Option  Agreement  shall specify the number
of Shares that are subject to the Option.  The Stock Option Agreement shall also
specify whether the Option is an ISO or a Nonstatutory Option.

     (c) Exercise Price.  Each Stock Option Agreement shall specify the Exercise
Price.  The Exercise  Price under any Option shall be determined by the Board of
Directors at its sole discretion,  subject to the following limitations: (i) the
Exercise Price of an ISO shall not be less than 100% of the Fair Market Value of
a Share  on the  date of  grant  (110%  for an ISO  granted  to a  Greater  Than
Ten-Percent  Stockholder)  and (ii) in no event  may the  Exercise  Price of any
Option be less than the par value of a Share.

     (d) Special Rule for Incentive Options.  Consistent with Section 422 of the
Code and any regulations,  notices or other official  pronouncements  of general
applicability, to the extent the aggregate Fair Market Value (as of the time the
Option  is  granted)  of the  Shares of Stock  with  respect  to which  ISOs are
exercisable  for the first time by an Optionee  during any calendar  year (under
all  plans  of  his  employer   corporation   and  its  Parent  and   Subsidiary
corporations)  exceeds  $100,000,  such  Options  shall not be treated as ISO's.
Nothing in this special  rule shall be construed as limiting the  exercisability
of any Option,  unless the Stock Option Agreement  expressly provides for such a
limitation.

     (e)  Withholding  Taxes.  As a condition to the exercise of an Option,  the
Optionee shall make such  arrangements as the Board of Directors may require for
the  satisfaction  of any  federal,  state,  local or  foreign  withholding  tax
obligations that may arise in connection with such exercise.  The Optionee shall
also make such arrangements as the Board of Directors may require

                                       2

<PAGE>

for the  satisfaction of any federal,  state,  local or foreign  withholding tax
obligations that may arise in connection with the disposition of Shares acquired
by exercising an Option.

     (f) Exercisability. Each Stock Option Agreement shall specify the date when
all  or  any   installment  of  the  Option  is  to  become   exercisable.   The
exercisability  provisions of any Stock Option  Agreement shall be determined by
the Board of Directors at its sole discretion.

     (g) Basic Term.  The Stock Option  Agreement  shall specify the term of the
Option.  The term shall not exceed 10 years from the date of grant (five  years,
in the  case of an ISO  granted  to a  Greater  Than  Ten-Percent  Stockholder).
Subject to the preceding sentence, the Board of Directors at its sole discretion
shall  determine  when an Option is to  expire.  A Stock  Option  Agreement  may
provide  for  expiration  prior  to the  end of its  term  in the  event  of the
termination of Optionee's Service or death or any other circumstances.

     (h) Nontransferability.  No Option may be transferred other than by will or
by the laws of descent and distribution, and during the lifetime of the Optionee
may be  exercised  only by the Optionee or by the  Optionee's  guardian or legal
representative;  provided,  however,  that an  Option  that is not an ISO may be
otherwise  transferred  to  the  extent,  if  any,  permitted  by the  Board  of
Directors.

     (i)  No  Rights  as a  Stockholder.  An  Optionee,  or a  transferee  of an
Optionee,  shall  have no rights as a  stockholder  with  respect  to any Shares
covered by the  Optionee's  Option until such Shares are issued  pursuant to the
terms of such Option.

     (j)  Modification  and Extension of Options.  Within the limitations of the
Plan,  the  Board of  Directors  may  modify or extend  Options.  The  foregoing
notwithstanding,  no modification of an Option shall, without the consent of the
Optionee,  impair the Optionee's  rights or increase the Optionee's  obligations
under such Option.

     (k) Substitution of Options. The Board of Directors may grant Options under
the Plan in  substitution  for options held by employees of another  corporation
who  concurrently  become  employees of the Company or a Parent or Subsidiary as
the result of a merger or  consolidation  of the employing  corporation with the
Company or a Parent or  Subsidiary,  or as the result of the  acquisition by the
Company of  property  or stock of the  employing  corporation.  The  Company may
direct that  substitute  awards be granted on such terms and  conditions  as the
Board of Director considers appropriate in the circumstances.

     (l)  Restrictions  on Transfer of Shares and  Minimum  Vesting.  Any Shares
issued upon  exercise of an Option shall be subject to such  special  forfeiture
conditions,  rights of  repurchase,  rights of first refusal and other  transfer
restrictions as the Board of Directors may determine. Such restrictions shall be
set forth in the applicable  Stock Option  Agreement and shall apply in addition
to any restrictions that may apply to holders of Shares generally.

                                       3


<PAGE>

SECTION 6. Payment For Shares.

     (a) General Rule. The entire Exercise Price of Shares issued under the Plan
shall be  payable,  at the time when such Option is  exercised,  in cash or cash
equivalents payable to the order of the Company, except as otherwise provided in
this Section 6.

     (b) Surrender of Stock. Unless a Stock Option Agreement otherwise provides,
all or any part of the Exercise Price may be paid by surrendering,  or attesting
to the ownership of, Shares that are already owned by the Optionee.  Such Shares
shall be  surrendered  to the  Company  in good form for  transfer  and shall be
valued at their Fair Market Value on the date when the Option is exercised.  The
Optionee shall not  surrender,  or attest to the ownership of, Shares in payment
of the  Exercise  Price if such  action  would  cause the  Company to  recognize
compensation  expense (or additional  compensation  expense) with respect to the
Option for financial reporting purposes.

     (c) Promissory Note.  Unless a Stock Option Agreement  otherwise  provides,
all or a portion of the  Exercise  Price of Shares  issued under the Plan may be
paid with a  full-recourse  promissory  note  (provided  that the Optionee is an
Employee of the Company). The Shares shall be pledged as security for payment of
the principal amount of the promissory note and interest  thereon.  The interest
rate payable under the terms of the  promissory  note shall not be less than the
minimum rate (if any) required to avoid the  imputation  of additional  interest
under the Code.  Subject to the  foregoing,  the Board of Directors (at its sole
discretion) shall specify the term, interest rate, amortization requirements (if
any) and other provisions of such note.

     (d) Exercise/Sale.  Unless a Stock Option Agreement  otherwise provides (or
if  otherwise  approved  by the Board of  Directors),  and if Stock is  publicly
traded, payment may be made all or in part by the delivery (on a form prescribed
by the Company) of an irrevocable  direction to a securities  broker approved by
the Company to sell  Shares and to deliver all or part of the sales  proceeds to
the Company in payment of all or part of the Exercise Price and any  withholding
taxes.

     (e) Exercise/Pledge. Unless a Stock Option Agreement otherwise provides (or
if  otherwise  approved  by the Board of  Directors),  and if Stock is  publicly
traded, payment may be made all or in part by the delivery (on a form prescribed
by the Company) of an  irrevocable  direction  to pledge  Shares to a securities
broker or lender approved by the Company, as security for a loan, and to deliver
all or part of the loan proceeds to the Company in payment of all or part of the
Exercise Price and any withholding taxes.

SECTION 7. ACQUISITION EVENTS AND OTHER Adjustment Of Shares.

     (a) Acquisition  Events. In the event of a consolidation or merger in which
the Company is not the surviving  corporation or in the event of any transaction
that  results  in  the  acquisition  of  substantially   all  of  the  Company's
outstanding  Stock by a single person or entity or by a group of persons  and/or
entities  acting in  concert,  or in the event of the sale or other  transfer of
substantially  all of the Company's  assets (all the foregoing being referred to
as "Acquisition

                                       4

<PAGE>

Events"),  outstanding  Options  shall be subject to the  agreement of merger or
consolidation.  Such agreement,  without the Optionee's consent, may provide for
any of the following:

          (i) The  continuation of such  outstanding  Options by the Company (if
     the Company is not the surviving corporation);

          (ii) The  assumption of the Plan and such  outstanding  Options by the
     surviving corporation or its parent;

          (iii) The  substitution by the surviving  corporation or its parent of
     options with substantially the same terms for such outstanding Options; or

          (iv) The cancellation of such  outstanding  Options without payment of
     any consideration.

     The  provisions of Section 7(b) below shall not apply to any Option that is
terminated pursuant to this Section 7(a).

     (b) Other  Events.  In the event that the  outstanding  Shares of Stock are
changed  into or  exchanged  for a  different  number or kind of shares or other
securities or property (including cash) of the Company or of another corporation
by  reason  of  a  stock  dividend,   stock  split  or  combination  of  shares,
recapitalization or other change in the Company's capital stock, reorganization,
merger,  sale or other  transfer of  substantially  all the Company's  assets to
another corporation,  consolidation,  or other transaction  described in Section
424(a) of the Code, the Board of Directors  shall make  appropriate  adjustments
(in such manner as it deems equitable in its sole  discretion) in (i) the number
and kind of shares of Stock,  other  securities  or property for the purchase of
which Options may be granted under the Plan,  (ii) the number and kind of shares
of Stock,  other  securities  or property as to which  outstanding  Options,  or
portions  thereof then  unexercised,  shall be  exercisable,  (iii) the Exercise
Price  and  other  terms of  outstanding  Options  and (iv) any  other  relevant
provisions of the Plan.  Any  adjustment of the Plan or in  outstanding  Options
shall be  effective  on the  effective  date of the  event  giving  rise to such
adjustment.  The Board of Directors may also adjust the number of Shares subject
to outstanding  options, the Exercise Price of outstanding Options and the terms
of outstanding  Options to take into  consideration  any other event (including,
without  limitation,  accounting  changes) if the Board of Directors  determines
that such adjustment is appropriate to avoid  distortion in the operation of the
Plan. All determinations and adjustments made by the Board of Directors pursuant
to this Section 7(b) shall be binding on all persons.

     (c)  Reservation  of Rights.  The grant of an Option  pursuant  to the Plan
shall  not  affect  in any  way  the  right  or  power  of the  Company  to make
adjustments,  reclassifications,  reorganizations  or changes of its  capital or
business structure, to merge or consolidate or to dissolve,  liquidate,  sell or
transfer all or any part of its business or assets.

     (d)  Sale or  Merger.  "Sale"  means:  (i) sale  (other  than a sale by the
Company)  of  securities  entitled  to more than 75% of the voting  power of the
Company in a single  transaction  or a related series of  transactions;  or (ii)
sale of substantially all of the assets of the Company; or

                                       5

<PAGE>

(iii) approval by the stockholders of the Company of a reorganization, merger or
consolidation  of the  Company,  as a result of which the  persons  who were the
stockholders of the Company immediately prior to such reorganization,  merger or
consolidation do not own securities immediately after the reorganization, merger
or  consolidation  entitled  to  more  than  50%  of  the  voting  power  of the
reorganized,   merged  or  consolidated   company.   Notwithstanding  the  other
provisions  of this Section 7,  immediately  prior to a Sale,  each Optionee may
exercise  his or her  Option  as to  all  Shares  then  subject  to the  Option,
regardless of any vesting conditions  otherwise expressed in the Option.  Voting
power, as used in this Section 7(d), shall refer to those securities entitled to
vote  generally in the election of directors,  and securities of the Company not
entitled to vote but which are convertible into, or exercisable for,  securities
of the Company  entitled to vote generally in the election of directors shall be
counted as if converted or exercised,  and each unit of voting  securities shall
be counted in proportion to the number of votes such unit is entitled to cast.

SECTION 8. Securities Law Requirements.

     The  Company  shall not be  obligated  to  deliver  any Shares of Stock (a)
until, in the opinion of the Company's counsel, all applicable federal and state
laws and regulations  have been complied with, and (b) if the outstanding  Stock
is at the time listed on any stock  exchange or other  stock  market,  until the
Shares to be  delivered  have been  listed  or  authorized  to be listed on such
exchange or other stock market upon official  notice of issuance,  and (c) until
all other legal  matters in  connection  with the  issuance and delivery of such
Shares have been approved by the Company's counsel. If the sale of Stock has not
been  registered  under the Securities Act of 1933, as amended,  the Company may
require,  as a condition  to exercise of the  Option,  such  representations  or
agreements  as  counsel  for the  Company  may  consider  appropriate  to  avoid
violation  of such Act and may require  that the  certificates  evidencing  such
Stock bear an appropriate legend restricting transfer.

SECTION 9. No Retention Rights.

     Nothing in the Plan or in any right or Option  granted under the Plan shall
confer  upon the  Optionee  any right to  continue  in Service for any period of
specific duration or interfere with or otherwise  restrict in any way the rights
of the Company (or any Parent or Subsidiary employing or retaining the Optionee)
or of the  Optionee,  which  rights are hereby  expressly  reserved by each,  to
terminate  his or her  Service at any time and for any  reason,  with or without
cause.

SECTION 10. Duration and Amendments.

     (a) Term of the Plan. The Plan, as set forth herein, shall become effective
on the date of its adoption by the Board of  Directors,  subject to the approval
of the  Company's  stockholders.  In the  event  that the  stockholders  fail to
approve the Plan within 12 months after its adoption by the Board of  Directors,
any grants of Options  that have already  occurred  shall be  rescinded,  and no
additional  grants  shall be made  thereafter  under  the Plan.  The Plan  shall
terminate

                                       6

<PAGE>

automatically  10 years after its adoption by the Board of Directors  and may be
terminated on any earlier date pursuant to Section 10(b).

     (b) Right to Amend or Terminate the Plan. The Board of Directors may amend,
suspend or terminate the Plan at any time and for any reason; provided, however,
that any amendment of the Plan that increases the number of Shares available for
issuance  under the Plan  (except as provided  in Section 7), or that  otherwise
materially  changes the class of persons who are eligible for the grant of ISOs,
will be subject to the approval of the stockholders of the Company.  Stockholder
approval shall not be required for any other amendment of the Plan.

     (c) Effect of Amendment or  Termination.  No Shares shall be issued or sold
under the Plan after the termination thereof,  except upon exercise of an Option
granted prior to such termination. The termination of the Plan, or any amendment
thereof, shall not affect any Option previously granted under the Plan.

SECTION 11. Definitions.

     (a) "Board of Directors"  shall mean the Board of Directors of the Company,
as constituted from time to time.

     (b) "Code" shall mean the Internal Revenue Code of 1986, as amended.

     (c)  "Committee"  shall  mean a  committee  of the Board of  Directors,  as
described in Section 2(a).

     (d) "Company" shall mean Pharmos Corporation, a Nevada corporation.

     (e)  "Consultant"  shall mean a person who performs  bona fide services for
the Company,  a Parent or a Subsidiary  as a  consultant  or advisor,  excluding
Employees and Outside Directors.

     (f) "Employee"  shall mean any  individual who is a common-law  employee of
the Company, a Parent or a Subsidiary.

     (g)  "Exercise  Price"  shall  mean the  amount  for which one Share may be
purchased upon exercise of an Option,  as specified by the Board of Directors in
the applicable Stock Option Agreement.

     (h) "Fair Market  Value" shall be  determined by the Committee or the Board
of Directors in its discretion; provided, that if the Stock is listed on a stock
exchange,  the Fair Market  Value per Share  shall be the closing  price on such
exchange  on the date of grant of the  Option  as  reported  in the Wall  Street
Journal (or, (i) if not so reported, as otherwise reported by the exchange,  and
(ii) if not reported on the date of grant,  then on the last prior date on which
a sale of the Stock was reported); or if not listed on an exchange but traded on
the National  Association of Securities  Dealers  Automated  Quotation  National
Market System  ("NASDAQ"),  the Fair Market Value per Share shall be the closing
price per share of the Stock  for the date of  grant,  as  reported  in the Wall
Street Journal (or, (i) if not so reported, as

                                       7

<PAGE>

otherwise  reported  by NASDAQ,  and (ii) if not  reported on the date of grant,
then on the last prior date on which a sale of the Common  Stock was  reported);
or, if the Stock is otherwise publicly traded, the mean of the closing bid price
and asked price for the last known sale.

     (i) "Greater Than  Ten-Percent  Stockholder"  as of any time shall mean any
Employee  who at such time owns  directly,  or is deemed to own by reason of the
attribution rules set forth in Section 424(d) of the Code, stock possessing more
than 10% of the  total  combined  voting  power of all  classes  of stock of the
Company.

     (j) "ISO"  shall mean an  employee  incentive  stock  option  described  in
Section 422(b) of the Code.

     (k)  "Nonstatutory  Option"  shall  mean a stock  option not  described  in
Sections 422(b) or 423(b) of the Code.

     (l) "Option"  shall mean an ISO or  Nonstatutory  Option  granted under the
Plan and entitling the holder to purchase Shares.

     (m) "Optionee" shall mean an individual who holds an Option.

     (n) "Outside Director" shall mean a member of the Board of Directors who is
not an Employee.

     (o)  "Parent"  shall mean any  corporation  (other than the  Company) in an
unbroken  chain  of  corporations  ending  with  the  Company,  if  each  of the
corporations  other than the Company  owns stock  possessing  50% or more of the
total  combined  voting  power  of all  classes  of  stock  in one of the  other
corporations in such chain. A corporation that attains the status of a Parent on
a date after the adoption of the Plan shall be considered a Parent commencing as
of such date.

     (p) "Plan" shall mean this Pharmos Corporation 2000 Stock Option Plan.

     (q)  "Service"  shall mean  service as an  Employee,  Outside  Director  or
Consultant.

     (r) "Share" shall mean one share of Stock,  as adjusted in accordance  with
Section 7 (if applicable).

     (s) "Stock" shall mean the Common Stock of the Company, with a par value of
$0.03 per Share.

     (t) "Stock Option  Agreement" shall mean the agreement  between the Company
and an Optionee which contains the terms, conditions and restrictions pertaining
to the Optionee's Option.

     (u)  "Subsidiary"  means any  corporation  (other  than the  Company) in an
unbroken  chain  of  corporations  beginning  with the  Company,  if each of the
corporations  other than the last  corporation  in the unbroken chain owns stock
possessing  50% or more of the total  combined  voting  power of all  classes of
stock in one of the other corporations in such chain. A corporation

                                       8

<PAGE>

that attains the status of a Subsidiary on a date after the adoption of the Plan
shall be considered a Subsidiary commencing as of such date.

SECTION 12. Execution.

     To record the adoption of the Plan by the Board of  Directors,  the Company
has caused its authorized officer to execute the same.

                                      PHARMOS CORPORATION



                                      -----------------------------------------
                                      Robert W. Cook
                                      Vice President/Finance and Administration,
                                      Chief Financial Officer


                                       9

<PAGE>

                               PHARMOS CORPORATION
                        99 Wood Avenue South - Suite 301
                            Iselin, New Jersey 08830
                                 (732) 452-9556

                 PROXY SOLICITED ON BEHALF OF BOARD OF DIRECTORS
                 Annual Meeting of Stockholders - July 20, 2000

     The  undersigned,  as stockholder of Pharmos  Corporation  (the  "Company")
hereby  appoints Haim Aviv and Gad Riesenfeld and each of them,  with full power
of  substitution,  the true and  lawful  proxies  and  attorneys  in fact of the
undersigned,  to vote, as designated on the reverse side of this proxy card, the
number of shares of Common Stock of the Company which the  undersigned  would be
entitled to vote, as fully and with the same effect as the undersigned  might do
if personally  present,  at the Annual Meeting of Stockholders of the Company to
be held on July 20,  2000 at 11:00 AM in  Edison,  New  Jersey  at the  Sheraton
Edison Hotel, 125 Raritan Center Parkway,  and any  adjournments  thereof on the
following  matters as set forth in the Proxy Statement and Notice dated June 16,
2000.

                         (To be Signed on Reverse Side)


[X]  Please mark your votes as in this example.

                      FOR all             WITHHOLD          NOMINEES:
                      Nominees            AUTHORITY to      Haim Aviv
                      listed at right     vote for all      E. Andrews Grinstead
                      (except as          nominees listed   Elkan R. Gamzu
 1. Election of       marked to the       at right          Samuel D. Waksal
 Directors of the     contrary)                             David Schlachet
 Company (Item        [_]                 [_]               Tony Marcel
 No. 1 in the                                               Mony Ben Dor
 Proxy Statement).

(INSTRUCTIONS:  To withhold authority to vote for any individual nominee,  PRINT
that nominee's name on the line below)

- --------------------------------------------------------------------------------

2. Proposal to adopt the Pharmos            For        Against        Abstain
Corporation 2000 Stock Option               [_]        [_]              [_]
Plan (Item No. 2 in the Proxy
Statement).


<PAGE>

3. In the  discretion  of such proxies upon all other matters which may properly
come before the Annual Meeting.

This proxy, when properly executed,  will be voted in the manner directed herein
by the  undersigned  stockholder.  If no direction  is made,  this proxy will be
voted for the  election  of the  nominees to the board of  directors  identified
above,  for the approval of the amendment,  for the amendment of the option plan
and,  in the  discretion  of the  proxies  named,  on such other  matters as may
properly come before the Annual Meeting.

This proxy is revocable at any time, and the  undersigned  reserves the right to
attend the Annual Meeting and vote in person. The undersigned hereby revokes any
proxy heretofore given in respect of the shares of the Company.

THE  BOARD OF  DIRECTORS  URGES  THAT YOU FILL IN,  SIGN AND DATE THE  PROXY AND
RETURN IT PROMPTLY BY MAIL IN THE ENCLOSED ENVELOPE.  NO POSTAGE IS NECESSARY IF
MAILED IN THE UNITED STATES.

CORRECT ADDRESS IF NECESSARY

Signature(s)___________________________________________

Date__________________

Note:  Please sign  exactly as name(s)  appear on your Stock  Certificate.  When
signing as attorney, executor,  administrator,  trustee or guardian, please give
full  title as such.  If more  than one name is  shown,  as in the case of joint
tenancy,  each party must sign. If a corporation,  please sign in full corporate
name by the president or other authorized officer.




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