BIOGEN INC
10-Q, 1994-04-21
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                    SECURITIES AND EXCHANGE COMMISSION    Total Pages-   19
                          WASHINGTON, D.C. 20549          Exhibit Index- 11
                                                

                                 FORM 10-Q
(Mark one)

[X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934

For the quarterly period ended       March 31, 1994      

                                    OR

[ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934

For the transition period from                   to                   

                      Commission File Number 0-12042
                                                         


                               BIOGEN, INC.                     
                                                                  

          (Exact name of registrant as specified in its charter)


            Massachusetts                           04-3002117             
   (State or other jurisdiction of     (I.R.S. Employer Identification No.)
   incorporation or organization)

 14 Cambridge Center, Cambridge, MA                    02142               
(Address of principal executive offices)            (Zip Code)


    Registrant's telephone number, including area code:  (617) 252-9200

    Former name, former address and former fiscal year, if changed since
last report:   Not Applicable


    Indicate by check mark whether the registrant (1) has filed all
reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter
period that the registrant was required to file such reports), and (2) has
been subject to such filing requirements for the past 90 days.
                             Yes  X    No     

    Number of shares outstanding of each of the issuer's classes of common
stock, as of April 15, 1994:

    Common Stock, par value $0.01                   32,418,602             
        (Title of each class)                   (Number of Shares)

<PAGE>
                          B I O G E N , I N C .                      Page 2


                                   INDEX

                                                                  Page No.

PART I - FINANCIAL INFORMATION

  Condensed Consolidated Balance Sheets -
    March 31, 1994 and December 31, 1993. . . . . . . . . . . . . . .3

  Condensed Consolidated Statements of Income -
    Three months ended March 31, 1994 and 1993. . . . . . . . . . . .4

  Condensed Consolidated Statements of Cash Flows -
    Three months ended March 31 1994 and 1993 . . . . . . . . . . . .5

  Notes to Condensed Consolidated Financial Statements. . . . . . . .6

  Management's Discussion and Analysis of Financial
    Condition and Results of Operations . . . . . . . . . . . . . . .7

  Report of Independent Accountants . . . . . . . . . . . . . . . . .9


PART II - OTHER INFORMATION . . . . . . . . . . . . . . . . . . . . 10



                   * * * * * * * * * * * * * * * * * * 












Note concerning trademarks:   Certain names mentioned in this report are
                              trademarks owned by Biogen, Inc. or its
                              affiliates or licensees.  Hirulog(TM) is a
                              trademark of Biogen, Inc.



<PAGE>
                       BIOGEN, INC. AND SUBSIDIARIES                 Page 3

                   CONDENSED CONSOLIDATED BALANCE SHEETS
                              (in thousands)

                                              March 31,1994  Dec. 31,1993
                                               (unaudited)
ASSETS
   Current assets
     Cash and cash equivalents. . . . . . . . .  $ 52,704     $ 74,546
     Marketable securities. . . . . . . . . . .   243,433      195,805
     Accounts receivable. . . . . . . . . . . .     8,178       31,695
     Other. . . . . . . . . . . . . . . . . . .     7,482        7,378
                                                 --------     --------
     Total current assets . . . . . . . . . . .   311,797      309,424
                                                 --------     --------
   Property and equipment
     Total cost . . . . . . . . . . . . . . . .    70,669       64,111
     Less accumulated depreciation. . . . . . .    26,863       25,611
                                                 --------     --------
     Property and equipment, net. . . . . . . .    43,806       38,500
                                                 --------     --------
   Other assets                                
     Patents, net . . . . . . . . . . . . . . .     7,184        7,164
     Other. . . . . . . . . . . . . . . . . . .     2,206        1,862
                                                 --------     --------
     Total other assets . . . . . . . . . . . .     9,390        9,026
                                                 --------     --------
                                                 $364,993     $356,950
                                                 ========     ========


LIABILITIES AND SHAREHOLDERS' EQUITY
   Current liabilities
     Accounts payable . . . . . . . . . . . . .  $  4,052     $  2,916
     Other current liabilities. . . . . . . . .    25,478       28,860
                                                 --------     --------
     Total current liabilities. . . . . . . . .    29,530       31,776
                                                 --------     --------
   Shareholders' equity
     Common stock . . . . . . . . . . . . . . .       324          323
     Additional paid-in capital . . . . . . . .   352,314      353,247
     Deficit. . . . . . . . . . . . . . . . . .   (17,234)     (28,462)
     Accumulated translation adjustment . . . .        59           66
                                                 --------     --------
     Total shareholders' equity . . . . . . . .   335,463      325,174
                                                 --------     --------
                                                 $364,993     $356,950
                                                 ========     ========

See Notes to Condensed Consolidated Financial Statements.





<PAGE>
                       BIOGEN, INC. AND SUBSIDIARIES                 Page 4

                CONDENSED CONSOLIDATED STATEMENTS OF INCOME
                                (unaudited)
                 (in thousands, except per share amounts)



                                                  Three months ended
                                           March 31,1994      March 31,1993
REVENUES

 Royalties and product sales. . . . . .      $ 41,167            $ 32,540
 Interest . . . . . . . . . . . . . . .         3,613               2,881
                                             --------            --------
 Total revenues . . . . . . . . . . . .        44,780              35,421
                                             --------            --------
EXPENSES

 Cost of sales. . . . . . . . . . . . .         2,471               2,819
 Research and development . . . . . . .        23,334              14,965
 General and administrative . . . . . .         5,963               3,953
 Other. . . . . . . . . . . . . . . . .           103               1,344
                                             --------            --------
 Total expenses . . . . . . . . . . . .        31,871              23,081
                                             --------            --------
INCOME BEFORE INCOME TAXES. . . . . . .        12,909              12,340

Income taxes. . . . . . . . . . . . . .         1,680               1,080
                                             --------            --------
NET INCOME. . . . . . . . . . . . . . .      $ 11,229            $ 11,260
                                             ========            ========

NET INCOME PER SHARE. . . . . . . . . .      $   0.31            $   0.32
                                             ========            ========

Average shares outstanding. . . . . . .        35,741              34,766
                                             ========            ========


See Notes to Condensed Consolidated Financial Statements.





<PAGE>
                       BIOGEN, INC. AND SUBSIDIARIES                 Page 5

              CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                (unaudited)
                              (in thousands)

                                                  Three months ended 
                                                       March 31,     
                                                  1994         1993  

CASH FLOWS FROM OPERATING ACTIVITIES
 Net income . . . . . . . . . . . . . . . . . . $ 11,229      $11,260
 Adjustments to reconcile net income to net 
  cash provided from operating activities:
  Depreciation and amortization . . . . . . . .    1,764        1,840
  Write-off of investment in joint venture. . .       --        1,803
  Other . . . . . . . . . . . . . . . . . . . .     (152)        (462)
  Changes in:
    Accounts receivable . . . . . . . . . . . .   23,517        6,013
    Other current assets. . . . . . . . . . . .     (104)        (400)
    Other assets. . . . . . . . . . . . . . . .     (344)         375
    Accounts payable and 
     other current liabilities. . . . . . . . .   (2,246)      (3,693)
                                                --------      --------
 Net cash provided from operating activities. .   33,664       16,736
                                                --------      --------
CASH FLOWS FROM INVESTING ACTIVITIES
 Purchases of marketable securities, net. . . .  (50,609)     (53,993)
 Acquisitions of property and equipment . . . .   (6,558)      (1,489)
 Additions to patents . . . . . . . . . . . . .     (533)        (863)
                                                --------      --------
 Net cash used by investing activities. . . . .  (57,700)     (56,345)
                                                --------      --------
CASH FLOWS FROM FINANCING ACTIVITIES
 Issuance of common stock . . . . . . . . . . .    2,194        1,142
                                                --------      --------
 Net cash provided from financing activities. .    2,194        1,142
                                                --------      --------

NET DECREASE IN CASH AND CASH EQUIVALENTS . . .  (21,842)     (38,467)

CASH AND CASH EQUIVALENTS, 
 BEGINNING OF PERIOD. . . . . . . . . . . . . .   74,546       85,863
                                                --------      --------
CASH AND CASH EQUIVALENTS,
 END OF PERIOD. . . . . . . . . . . . . . . . . $ 52,704      $47,396
                                                ========      ========


See Notes to Condensed Consolidated Financial Statements.



<PAGE>
                       BIOGEN, INC. AND SUBSIDIARIES                 Page 6

           NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                (unaudited)



1.  In the opinion of management, the accompanying unaudited condensed
    consolidated financial statements include all adjustments, consisting
    of only normal recurring accruals, necessary to present fairly the
    financial position, results of operations and cash flows of the
    Company.  The Company's accounting policies are described in the Notes
    to Consolidated Financial Statements in the Company's 1993 Annual
    Report.  Interim results are not necessarily indicative of the
    operating results for the full year.

2.  During the first quarter of 1994, the Company entered into an
    agreement with a bank to sell certain foreign based accounts
    receivable up to $14 million, which approximated the proceeds for the
    current quarter.  The selling price is partially determined by foreign
    exchange rates at the end of each quarter.

3.  As of January 1, 1994, the Company adopted Statement of Financial
    Accounting Standards No. 115, Accounting for Certain Investments in
    Debt and Equity Securities.  Under this standard, the Company is
    required to classify its marketable securities (all of which are debt
    securities) into one or more of the following categories: held-to-
    maturity, trading or available-for-sale.  At March 31, 1994, all of
    the Company's marketable securities are classified as available-for
    sale.  Under this statement, these securities are recorded at fair
    market value and unrealized gains and losses are recorded as part of
    shareholders' equity.  Following is a summary of marketable securities
    as of March 31, 1994: 


                                                  Unrealized     Amortized
     (dollars in thousands)            Value    Gains    Losses    Cost

     U.S. Government securities      $196,614    $444    $2,366  $198,536
     (average maturity of 24 months)

     Corporate debt securities         87,862     212     1,415    89,065
     (average maturity of 24 months)

     Proceeds from maturities and other sales of securities, which were
     reinvested, during the quarter ended March 31, 1994 were $247.7
     million.  Gross realized gains and losses on these sales were
     immaterial.





<PAGE>
                       BIOGEN, INC. AND SUBSIDIARIES                 Page 7


             MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
                    CONDITION AND RESULTS OF OPERATIONS


Results of Operations

For the first quarter ended March 31, 1994, the Company reported net income
of $11.2 million or $0.31 per share as compared to net income of $11.3
million or $0.32 per share in the first quarter of 1993.  

Total revenues for the first quarter of 1994 were $44.8 million, as
compared to $35.4 million in the first quarter of 1993.  Revenues for the
current quarter were higher than the comparable 1993 quarter due mostly to
higher royalty income.  During the first quarter, the Company signed a
licensing agreement with Eli Lilly & Co. ("Lilly") covering certain patent
rights for gene expression methods.  Under this agreement, Lilly paid the
Company approximately $10M in royalties that related to sales occurring
before 1994.  Royalties from alpha interferon sales by Schering-Plough
Corporation declined in the current quarter as compared to 1993, due
primarily to lower sales in Japan.  Sales in Japan declined in anticipation
of a 17 percent decrease in the price of alpha interferon, which became
effective on April 1.  The Company, in general, expects continued increases
in sales of licensed products but at lower growth rates than had been
experienced during 1992 and 1993.  However, there are numerous health care
reform initiatives currently underway in the United States and other major
pharmaceutical markets and it is not yet clear what effect, if any, these
initiatives or other developments may have on product sales by the
Company's licensees.  In addition, these sales levels may fluctuate from
quarter to quarter due to the timing and extent of major events such as new
indication approvals or licensing arrangements.

Interest income for the current quarter increased from the comparable 1993
amount due primarily to the increase in invested funds generated from
higher revenue and profit levels.

Total expenses for the current quarter were $31.9 million as compared to
$23.1 million in the 1993 quarter.  Research and development expense
increased $8.4 million, due to the expanded clinical development of the
Company's lead drug candidates, Hirulog(TM) thrombin inhibitor and
recombinant beta interferon.  Both drug candidates are in Phase II and
Phase III clinical trials for a variety of indications.  The Company
expects its research and development costs to continue to increase as it
expands the clinical programs for Hirulog(TM), recombinant beta interferon
and other therapeutics.  General and administrative expenses increased by
$2.0 million due mostly to higher costs related to market development
efforts, legal and personnel related costs.  Other expenses decreased
primarily due to a charge in the prior year's quarter for the write-off of
the Company's remaining interest in a European joint venture.

Income tax expense for the current quarter was $1.7 million which is
substantially less than the amount computed at U.S. federal statutory rates
because of the utilization of net operating loss carryforwards.  


<PAGE>
Financial Condition                                                  Page 8

At March 31, 1994, cash, cash equivalents and marketable securities
amounted to $296.1 million, a $25.7 million increase from the $270.4
million on hand at the end of 1993.  Working capital increased $4.6 million
to $282.3 million.  Net cash provided from operating activities for the
three months ended March 31, 1994 was $33.7 million while the Company's
common stock option and purchase plans provided $2.2 million.  Outflows of
cash included investments in property and equipment and patents of $7.1
million.  The decrease in accounts receivable is primarily attributed to an
agreement the Company entered into with a bank in the first quarter of 1994
to sell certain accounts receivable.

The Company is the general partner of Biogen Medical Products Limited
Partnership ("BMPLP").  BMPLP was formed for the continued development of
commercial products based on gamma interferon and interleukin-2 (the
"partnership products").  The Company agreed to extend the term of the
development contract with BMPLP until December 31, 1994.  The Company has
not incurred any significant costs with respect to BMPLP in 1994 but has
the option to provide up to $9.2 million to BMPLP to continue development
of the partnership products.  

During the fourth quarter of 1993, the Company commenced construction of a
150,000 square foot building in Cambridge, Massachusetts to house research
laboratories and offices.  The anticipated cost of construction, including
land, is approximately $40 million.  Upon completion of the building in
1995, the Company has the option, subject to certain conditions, to obtain
a secured term loan with a bank for up to $25 million for a period of up to
10 years. 

The Company believes that the financial resources available to it,
including its current working capital and its existing and anticipated
contractual relationships, may be sufficient to finance its planned
operations and capital expenditures for the near term.  However, the
Company expects that it may have additional funding needs, the extent of
which will depend upon the level of royalties and product sales, the
outcome of clinical trial programs, the receipt and timing of required
regulatory approvals for products, the results of research and development
efforts and business expansion opportunities.  Accordingly, from time to
time, the Company may obtain funding through various means which could
include collaborative agreements, lease financings, sales of equity or debt
securities and other financing arrangements.



<PAGE>
                                                                     Page 9
With respect to the unaudited condensed consolidated financial information
of Biogen, Inc. and its subsidiaries at March 31, 1994 and for the three
month periods ended March 31, 1994 and 1993, Price Waterhouse reported that
they have applied limited procedures in accordance with professional
standards for a review of such information.  However, their separate report
dated April 15, 1994 appearing herein, states that they did not audit and
they do not express an opinion on that unaudited condensed consolidated
financial information.  Price Waterhouse has not carried out any
significant or additional audit tests beyond those which would have been
necessary if their report had not been included.  Accordingly, the degree
of reliance on their report on such information should be restricted in
light of the limited nature of the review procedures applied.  Price
Waterhouse is not subject to the liability provisions of Section 11 of the
Securities Act of 1933 for their report on the unaudited condensed
consolidated financial information because that report is not a "report" or
a "part" of the registration statement prepared or certified by Price
Waterhouse within the meaning of sections 7 and 11 of the Act.

                     REPORT OF INDEPENDENT ACCOUNTANTS

To the Board of Directors and Shareholders of Biogen, Inc.

We have reviewed the accompanying condensed consolidated balance sheet of
Biogen, Inc. and its subsidiaries as of March 31, 1994, and the related
condensed consolidated statements of income and of cash flows for the three
month periods ended March 31, 1994 and 1993.  This financial information is
the responsibility of the Company's management.

We conducted our review in accordance with standards established by the
American Institute of Certified Public Accountants.  A review of interim
financial information consists principally of applying analytical
procedures to financial data and making inquiries of persons responsible
for financial and accounting matters.  It is substantially less in scope
than an audit conducted in accordance with generally accepted auditing
standards, the objective of which is the expression of an opinion regarding
the financial statements taken as a whole.  Accordingly, we do not express
such an opinion.

Based on our review, we are not aware of any material modifications that
should be made to the accompanying condensed consolidated financial
information for it to be in conformity with generally accepted accounting
principles.

We previously audited in accordance with generally accepted auditing
standards, the consolidated balance sheet as of December 31, 1993, and the
related consolidated statements of income, of cash flows and of
shareholders' equity for the year then ended (not presented herein), and in
our report dated January 20, 1994 we expressed an unqualified opinion on
those consolidated financial statements.  In our opinion, the information
set forth in the accompanying condensed consolidated balance sheet as of
December 31, 1993, is fairly stated in all material respects in relation to
the consolidated balance sheet from which it has been derived.

/s/ Price Waterhouse
- ---------------------
Boston, Massachusetts
April 15, 1994<PAGE>

                        PART II - OTHER INFORMATION                 Page 10




Item 6 - Exhibits and Reports on Form 8-K

     (a) Exhibits      

         No. 10        Supplemental Amendment and Agreement dated as of
                       March 1, 1994 between Schering Corporation and the
                       Company.*
         No. 11        Computation of Earnings per Share.
         No. 15        Letter from Price Waterhouse.
         * Confidential treatment requested.

     (b) There were no reports on Form 8-K filed for the quarter ended
         March 31, 1994.










                                SIGNATURES


Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



                                        BIOGEN, INC.



Dated:  April 20, 1994                         /s/Timothy M. Kish          
                                        ----------------------------------
                                                 Timothy M. Kish
                                           Vice President-Finance and
                                             Chief Financial Officer



<PAGE>
                                 EXHIBITS                           Page 11



Index to Exhibits.

      No. 10      Supplemental Amendment and Agreement dated as of March
                  1,1994 between Schering Corporation and the Company.*

      No. 11      Computation of Earnings per Share.

      No. 15      Letter from Price Waterhouse.

      *  Confidential treatment requested.





                                EXHIBIT 10                          Page 12

<PAGE>
                              EXHIBIT 10                       Page 13

                                             * CONFIDENTIAL TREATMENT
                                               OMMITTED MATERIAL FILED
                                               SEPARATELY WITH THE SEC

                 SUPPLEMENTAL AMENDMENT AND AGREEMENT


     AGREEMENT dated March 1, 1994 between Schering Corporation, a
corporation organized under the laws of the State of New Jersey
("Schering"); and Biogen, Inc., a corporation organized under the laws
of the Commonwealth of Massachusetts ("Biogen").
     WHEREAS, Schering has obtained royalty bearing licenses from
Genentech, Inc. ("Genentech") with respect to U.S. patent Nos.
4,704,362 and 5,221,619 and related U.S. and international patents and
applications;
     WHEREAS, Biogen and Schering executed an Exclusive License and 
Development Agreement ("License Agreement") dated December 8, 1979 and
an Amendment and Settlement Agreement ("First Amendment Agreement")
dated September 29, 1988;
     WHEREAS, under the First Amendment Agreement Schering is entitled
to offset certain royalties paid to Genentech from the royalties to be
paid to Biogen with respect to Schering's sale of Licensed Product
(interferon-alpha);
     WHEREAS, a dispute has arisen between Schering and Biogen as to
the amount of Schering's royalties paid to Genentech that are
offsettable against Biogen's royalties due from Schering under the
First Amendment Agreement; and
     WHEREAS, Schering and Biogen agree that it is in their mutual
best interests to settle their dispute in accordance with the terms
and conditions set forth herein;
     NOW, THEREFORE, in consideration of the mutual covenants and
agreements herein contained, Schering and Biogen, intending to be
legally bound, do hereby agree as follows:
l.   Definitions
     1.1  All terms which are defined in the License Agreement and
First Amendment Agreement are used herein as so defined.

     1.2  "Dispute" shall mean all issues arising from or relating to
Schering's assertion that it is entitled to offset from royalties
payable to Biogen those royalties paid and/or payable to Genentech
totaling   *   as provided for in the License and Settlement Agreement
between Genentech and Schering dated June 29, 1993.

2.   Amendments to the First Amendment Agreement

     2.1  Effective upon execution of this Supplemental Amendment and
Agreement, Schering and Biogen release each other from the terms of
Paragraphs 1.6 and 3.5 of the First Amendment Agreement and substitute
therefor the provisions of Paragraph 2.2 below of this Agreement.  For
all other purposes, the remaining provisions of the License Agreement
and the First Amendment Agreement shall remain in full force and
effect, except that Paragraph 3.6 shall be amended to read as follows:
               "3.6 Notwithstanding any other provisions of the
               License Agreement, Schering shall not have the right to
               deduct from earned royalty due under the License
               Agreement with respect to given Licensed Products sold
               during any accounting period any royalty payable to any
               third party other than (i) the royalty payable under 
                                                               Page 14

               the Cohen-Boyer License as set forth in Section 3.3 of
               the First Amendment Agreement, (ii) the royalty payable
               under the NRDC License as set forth in Section 3.4 of
               the First Amendment Agreement (as modified by the
               Agreement dated January 7, 1994 among Schering, Biogen
               and British Technology Group Limited), and (iii) the
               royalty payable under the Genentech License to the
               extent, but only to the extent, set forth in the First
               Amendment Agreement as amended by this Supplemental
               Amendment and Agreement.

     2.2 Biogen agrees that Schering shall be entitled to deduct  * 
of the royalties paid to Genentech from the royalties paid or to be
paid to Biogen as provided for in the schedule set forth below, but in
no event more than         *          of the Sales Value of Licensed
Product sold by Schering in the indicated time period.  These amounts
include royalties already paid to Genentech and deducted from
royalties already paid to Biogen as indicated.
                                        Deductible From
     Maximum                            Biogen Royalties
     Deductible                         Due From Schering For
     Amount                             The Indicated Time Period
      *                                 Already Deducted From the 2nd
                                        Quarter 1993 Royalties
      *                                 Already Deducted From the 3rd
                                        Quarter 1993 Royalties

      *                                 4th Quarter 1993
      *                                 1st Quarter 1994
      *                                 2nd Quarter 1994
      *                                 3rd Quarter 1994
      *                                 4th Quarter 1994
      *                                 1st Quarter 1995
      *                                 2nd Quarter 1995
      *                                 3rd Quarter 1995
      *                                 4th Quarter 1995
      *                                 1st Quarter 1996
      *                                 2nd Quarter 1996
      *                                 3rd Quarter 1996
      *                                 4th Quarter 1996
_______________
The lesser of (i)  *   of               Each subsequent Quarter until
the Sales Value of Schering's            *      is deducted.
sales of Licensed Product or 
(ii)  *   minus the total
amount previously deducted.
     ___________
TOTAL    *

It is understood and agreed by the parties that the above schedule
allows Schering to make deductions from the royalties due to Biogen
until a total of    *    has been deducted, notwithstanding that all
royalty payments to Genentech may have been completed by the first
quarter of l997.
It is agreed by the parties that no royalties paid by Schering to
Genentech, other than as specifically set forth above, shall be
deductible from royalties due to Biogen under the License Agreement 

                                                               Page 15

and First Amendment Agreement, unless otherwise agreed to by the
parties in writing.
3.   Waiver and Release
     3.1  The parties hereby irrevocably waive and release each other
from each and every claim which was the subject of the Dispute,
including, but not limited to all claims one party may now or
hereafter have against the other party arising out of or relating to
such Dispute.
4.   Other Terms and Conditions
     4.1  This Supplemental Amendment and Agreement shall constitute
an amendment of the License Agreement within the meaning of Section 18
thereof.
     4.2  Except as expressly set forth herein, all of the other terms
and conditions of the License Agreement and the First Amendment
Agreement shall remain in full force and effect.
     IN WITNESS WHEREOF, the Parties have caused this instrument to be
executed by their officers, duly authorized, on the day and year first
written above.

BIOGEN, INC.             SCHERING CORPORATION


    /s/                       /s/
By ___________________   By ____________________
Vice President           Vice President




389774.1


                                EXHIBIT 11                          Page 16

<PAGE>
                                EXHIBIT 11                          Page 17

                       BIOGEN, INC. and SUBSIDIARIES

                     Computation of Earnings Per Share
                                (unaudited)
                 (in thousands, except per share amounts)


                                                 Three months ended
                                          March 31,1994       March 31,1993


Primary earnings per share

Weighted average number of 
 shares outstanding . . . . . . . .           32,402               31,795

Shares deemed outstanding from
 the assumed exercise of stock
 options and warrants . . . . . . .            3,339                2,971
                                             --------            --------
Total . . . . . . . . . . . . . . .           35,741               34,766
                                             ========            ========

Net income. . . . . . . . . . . . .          $ 11,229            $ 11,260
                                             ========            ========
Primary earnings per
 share of common stock. . . . . . .          $  0.31             $   0.32
                                             ========            ========


Fully diluted earnings per share (a)

Weighted average number of
 shares outstanding . . . . . . . .           32,402               31,795

Shares deemed outstanding from
 the assumed exercise of stock
 options and warrants . . . . . . .            3,339                2,971
                                             --------            --------
Total . . . . . . . . . . . . . . .           35,741               34,766
                                             ========            ========

Net income  . . . . . . . . . . . .          $ 11,229            $  11,260
                                             ========            ========

Fully diluted earnings
 per share of common stock. . . . .          $  0.31             $   0.32
                                             ========            ========


(a)   This calculation is submitted in accordance with Regulation S-K item
      601 (b) (11) although not required by Footnote 2 to Paragraph 14 of
      APB Opinion No. 15 because it results in dilution of less than 3%.





                                EXHIBIT 15                          Page 18


<PAGE>
                                EXHIBIT 15                          Page 19








Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C. 20549


Dear Sirs:

We are aware that our report dated April 15, 1994 (issued pursuant to the
provisions of Statement on Auditing Standards No. 71) on the unaudited
condensed consolidated balance sheet of Biogen, Inc. and subsidiaries at
March 31, 1994, and the related condensed consolidated statements of income
and of cash flows for the three month period then ended, is incorporated
by reference in the Prospectuses constituting part of its Registration
Statements on Form S-8, as amended (Nos. 2-87550, 2-96157, 33-9827, 33-
14742, 33-37312, 33-22378 and 33-41077 and as filed on September 21, 1993)
and on Form S-3, as amended (Nos. 33-14741, 33-14743, 33-20183 and 33-
51639).  We are also aware of our responsibilities under the Securities Act
of 1933.


Yours very truly,


/s/ Price Waterhouse
- --------------------
Boston, Massachusetts
April 19, 1994






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