BIOGEN INC
SC 13G/A, 1994-11-10
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


SCHEDULE 13G
Under the Securities Exchange Act of 1934

Amendment No.:1*

Name of Issuer:  Biogen, Inc.

Title of Class of Securities:  Common Stock


CUSIP Number:  09059710-5


Check the following line if a fee is being paid with this
statement __.  (A fee is not required only if the filing person: 
(1) has a previous statement on file reporting beneficial
ownership of more than five percent of the class of securities
described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of
such class.)(See Rule 13d-7).

*The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to
the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided
in a prior cover page.

The information required in the remainder of this cover page
shall not be deemed to be "filed" for the purpose of Section 18
of the Securities Exchange Act of 1934 ("Act") or otherwise
subject to the liabilities of that section of the Act but shall
be subject to all other provisions of the Act (however, see the
Notes).
<PAGE>
CUSIP No.:  09059710-5

1.  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         Janus Capital Corporation
         EIN #84-0765359

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    a.   ___
    b.   _X_

3.  SEC USE ONLY

4.  CITIZENSHIP OF PLACE OF ORGANIZATION
         Colorado

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON
WITH:

    5.   SOLE VOTING POWER
              -0-  

    6.   SHARED VOTING POWER
              1,469,300 **   
    
    7.   SOLE DISPOSITIVE POWER
              -0-

    8.   SHARED DISPOSITIVE POWER
              1,469,300 **

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,469,300 **

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    CERTAIN SHARES
         N/A

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         4.4% **

12. TYPE OF REPORTING PERSON
         IA, CO

**  See Item 4 of this filing
<PAGE>
CUSIP No.:  09059710-5

1.  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         Thomas H. Bailey
         SS ####-##-####

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    a.   ___
    b.   _X_

3.  SEC USE ONLY

4.  CITIZENSHIP OF PLACE OF ORGANIZATION
         USA

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON
WITH:

    5.   SOLE VOTING POWER
              -0-

    6.   SHARED VOTING POWER
              1,469,300 **

    7.   SOLE DISPOSITIVE POWER
              -0-

    8.   SHARED DISPOSITIVE POWER
              1,469,300 **

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,469,300  **
10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    CERTAIN SHARES
         N/A

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         4.4% **

12. TYPE OF REPORTING PERSON
         IN

**  See Item 4 of this filing
<PAGE>
Item 1.

    (a). Name of Issuer:  Biogen, Inc. ("Biogen")  
    
    (b). Address of Issuer's Principal Executive Offices:
         14 Cambridge Center 
         Cambridge , MA 02142 
         
Item 2.

    (a).-(c). Name, Principal Business Address, and Citizenship
              of Persons Filing:

         (1)  Janus Capital Corporation ("Janus Capital")
              100 Fillmore Street, Suite 300
              Denver, Colorado  80206-4923
              Citizenship:  Colorado

         (2)  Thomas H. Bailey ("Mr. Bailey")
              100 Fillmore Street, Suite 300
              Denver, Colorado  80206-4923
              Citizenship:  USA
         
    (d). Title of Class of Securities:  Common Stock 

    (e). CUSIP Number:  09059710-5

Item 3.  

    Janus Capital is an Investment Adviser registered under
    Section 203 of the Investment Advisers Act of 1940.

Item 4.  Ownership

         The information in items 1 and 5 through 11 on the
         cover pages (pp. 2 & 3) on Schedule 13G is hereby
         incorporated by reference.
<PAGE>
         Janus Capital is a registered investment adviser which
         furnishes investment advice to several investment
         companies registered under Section 8 of the Investment
         Company Act of 1940 and individual and institutional
         clients (collectively referred to herein as "Managed
         Portfolios").  As a result of its role as investment
         adviser or sub-adviser to the Managed Portfolios,
         Janus Capital may be deemed to be the beneficial owner
         of the shares of Biogen Common Stock held by such
         Managed Portfolios.  However, Janus Capital does not
         have the right to receive any dividends from, or the
         proceeds from the sale of, the securities held in the
         Managed Portfolios and disclaims any ownership
         associated with such rights.

         Mr. Bailey owns approximately 17.6% of Janus Capital. 
         In addition to being a stockholder of Janus Capital,
         Mr. Bailey serves as President and Chairman of the
         Board of Janus Capital and is filing this joint
         statement with Janus Capital as a result of such stock
         ownership and positions which may be deemed to enable
         him to exercise control over Janus Capital.  Mr.
         Bailey does not own of record any shares of Biogen
         Common Stock and he has not engaged in any transaction
         in Biogen Common Stock.  However, as a result of his
         position, Mr. Bailey may be deemed to have the power
         to exercise or to direct the exercise of such voting
         and/or dispositive power that Janus Capital may have
         with respect to Biogen Common Stock held by the
         Managed Portfolios.  All shares reported herein have
         been acquired by the Managed Portfolios, and Mr.
         Bailey specifically disclaims beneficial ownership
         over any shares of Biogen Common Stock that he or
         Janus Capital may be deemed to beneficially own. 
         Furthermore, Mr. Bailey does not have the right to
         receive any dividends from, or the proceeds from the
         sale of, the securities held in the Managed Portfolios
         and disclaims any ownership associated with such
         rights.
<PAGE>
Item 5.  Ownership of Five Percent or Less of a Class

         This statement is being filed to report the fact that
         as of the date hereof the reporting persons have
         ceased to be the beneficial owners of more than five
         percent of the class of securities.

         Janus Capital's Managed Portfolios have the right to
         receive all dividends from, and the proceeds from the
         sale of, the securities held in their respective
         accounts.

Item 6.  Ownership of More than Five Percent on Behalf of
         Another Person

         N/A
         
Item 7.  Identification and Classification of the Subsidiary
         Which Acquired the Security Being Reported on by the
         Parent Holding Company

         N/A

Item 8.  Identification and Classification of Members of the
         Group

         N/A

Item 9.  Notice of Dissolution of Group

         N/A
<PAGE>
Item 10.      Certification

         By signing below I certify that, to the best of my
         knowledge and belief, the securities referred to above
         were acquired in the ordinary course of business and
         were not acquired for the purpose of and do not have
         the effect of changing or influencing the control of
         the issuer of such securities and were not acquired in
         connection with or as a participant in any transaction
         having such purposes or effect.
<PAGE>
                                SIGNATURES

    After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this
statement is true, complete and correct.


JANUS CAPITAL CORPORATION

By  /s/  David C. Tucker                         11/09/94       
   David C. Tucker, Vice President                  Date



THOMAS H. BAILEY

By  /s/  David C. Tucker                          11/09/94     
   David C. Tucker                                  Date


   Under Power of Attorney dated 2/10/94
   On File with Schedule 13G for
   Navigators Group, Inc. 2/11/94      
<PAGE>   
       EXHIBIT A



                          JOINT FILING AGREEMENT


    In accordance with Rule 13d-1(f) under the Securities
Exchange Act of 1934, the persons named below agree to the joint
filing on behalf of each of them of a Statement on Schedule 13G
(including amendments thereto) with respect to the Common Stock
of Biogen, Inc. and further agree that this Joint Filing
Agreement be included as an Exhibit to such joint filings.  In
evidence thereof, the undersigned hereby execute this Agreement
as of the 9th   day of  November , 1994.


                        JANUS CAPITAL CORPORATION

                        By  /s/  David C. Tucker            
                           David C. Tucker, Vice President


                        THOMAS H. BAILEY

                        
                        By  /s/  David C. Tucker                
    
                           David C. Tucker

                           Under Power of Attorney dated 2/10/94 
                           On File with Schedule 13G for
                           Navigators Group, Inc. 2/11/94


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