CYPRESS BIOSCIENCE INC
SC 13D/A, 1996-11-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                     SECURITIES AND EXCHANGE COMMISSION

                           WASHINGTON, D.C. 20549


                                SCHEDULE 13D
                             (Amendment No. 1)

                 Under the Securities Exchange Act of 1934


                          Cypress Bioscience, Inc.
                              (Name of Issuer)


                  Common Stock, par value $.001 per share
                       (Title of Class of Securities)

                                2 232674 101
                               (CUSIP Number)


                  Paramount Capital Asset Management, Inc.
                       c/o Lindsay A. Rosenwald, M.D.
                             787 Seventh Avenue
                             New York, NY 10019
                               (212) 554-4300

                              with a copy to:

                           David R. Walner, Esq.
                  Paramount Capital Asset Management, Inc.
                             787 Seventh Avenue
                             New York, NY 10019
                               (212) 554-4372

    (Name, Address and Telephone Number of Person Authorized to Receive
                        Notices and Communications)


                              October 18, 1996
          (Date of Event which Requires Filing of this Statement)


     If the filing person has previously filed a statement on Schedule 13G
     to report the acquisition which is the subject of this Statement
     because of Rule 13d-1(b)(3) or (4), check the following: o

     Check the following box if a fee is being paid with this Statement: o



CUSIP No. 2 232674 101                          13D          


    1    NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Paramount Capital Asset Management, Inc.
    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    
                                                              (a)  (  )
                                                              (b)  (  )
   3     SEC USE ONLY

   4     SOURCE OF FUNDS*
         OO (see Item 3 below)

   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                    (   )
   6     CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

                              7    SOLE VOTING POWER
                                      None
             NUMBER OF
              SHARES          8    SHARED VOTING POWER
           BENEFICIALLY               2,367,134
             OWNED BY         
               EACH           9    SOLE DISPOSITIVE POWER
             REPORTING                None                
              PERSON                       
               WITH           10   SHARED DISPOSITIVE POWER 
                                      2,367,134              

   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,367,134

   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                    (   )

   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         7.5%

   14    TYPE OF REPORTING PERSON*
         CO



CUSIP No. 2 232674 101                             13D   


    1    NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aries Domestic Fund, L.P.
    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                              (a) (  )
                                                              (b) (  )   
   3     SEC USE ONLY

   4     SOURCE OF FUNDS*
         OO (see Item 3 below)

   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                  (   )

   6     CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

                              7     SOLE VOTING POWER
                                       None
             NUMBER OF         
              SHARES          8     SHARED VOTING POWER      
           BENEFICIALLY                1,064,367                
             OWNED BY         
               EACH           9     SOLE DISPOSITIVE POWER      
             REPORTING                 None                   
              PERSON              
               WITH           10    SHARED DISPOSITIVE POWER
                                       1,064,367            
                              
   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,064,367

   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      (   )

   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         3.4%

   14    TYPE OF REPORTING PERSON*
         PN



CUSIP No. 2 232674 101                             13D    


    1   NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        The Aries Trust
    2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                            (a) 
                                                            (b) 
   3    SEC USE ONLY

   4    SOURCE OF FUNDS*
        OO (see Item 3 below)

   5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
        ITEM 2(d) or 2(e)
                                                             (   )

   6    CITIZENSHIP OR PLACE OF ORGANIZATION
        Cayman Islands

                              7   SOLE VOTING POWER
                                     None
             NUMBER OF
              SHARES          8   SHARED VOTING POWER      
           BENEFICIALLY             1,302,767                
             OWNED BY       
               EACH           9   SOLE DISPOSITIVE POWER   
             REPORTING                None                   
              PERSON           
               WITH          10   SHARED DISPOSITIVE POWER   
                                    1,302,767               
                   
   11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        1,302,767

   12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                    (   )
 
   13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        4.1%

   14   TYPE OF REPORTING PERSON*
        OO (see Item 2)



CUSIP No. 2 232674 101                            13D    


    1    NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Lindsay A. Rosenwald, M.D.
    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                               (a)   (   )
                                                               (b)   (   )
   3     SEC USE ONLY

   4     SOURCE OF FUNDS*
         OO (see Item 3 below)

   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                      (   )

   6     CITIZENSHIP OR PLACE OF ORGANIZATION
         United States

                              7   SOLE VOTING POWER
                                     None
             NUMBER OF
              SHARES          8   SHARED VOTING POWER       
           BENEFICIALLY              2,367,134                 
             OWNED BY         
               EACH           9   SOLE DISPOSITIVE POWER    
             REPORTING               None                      
              PERSON         
               WITH          10   SHARED DISPOSITIVE POWER     
                                     2,367,134                          
                             
   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,322,134

   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      (  )
 
   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         7.56%

   14    TYPE OF REPORTING PERSON*
         IN



Item 1. Security and Issuer.

        (a)    Common Stock, $.001 par value ("Shares")

               Cypress Bioscience, Inc. (the "Issuer")
               4350 Executive Drive, Suite 325
               San Diego, CA 92121
               (619) 452-2323

Item 2. Identity and Background.

        Names of Persons Filing:

        (a)    This statement is filed on behalf of Paramount Capital Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund,
               L.P. ("Aries Domestic"), The Aries Trust ("Aries Trust") and
               Dr. Lindsay A. Rosenwald (collectively, "Reporting
               Parties"). See attached Exhibit A which is a copy of their
               agreement in writing to file this statement on behalf of
               each of them.

        (b)    Paramount Capital's, Aries Domestic's and Dr. Rosenwald's
               business address is 787 Seventh Avenue, 44th Floor, New
               York, New York, 10019. The business address for Aries Trust
               is c/o MeesPierson (Cayman) Limited, P.O. Box 2003, British
               American Centre, Phase 3, Dr. Roy's Drive, George Town,
               Grand Cayman.

        (c)    Dr. Rosenwald is an investment banker, venture capitalist,
               fund manager and sole shareholder of Paramount Capital,1 a
               Subchapter S corporation incorporated in Delaware. Paramount
               Capital is the General Partner of Aries Domestic,2 a limited
               partnership incorporated in Delaware. Paramount Capital is
               the Investment Manager to Aries Trust,3 a Cayman Islands
               Trust.

        (d)    Dr. Rosenwald, Paramount Capital, Aries Domestic and Aries
               Trust and their respective officers, directors, general
               partners, investment managers, or trustees have not, during
               the five years prior to the date hereof, been con victed in
               a criminal proceeding (excluding traffic violations or
               similar misdemeanors).

        (e)    Dr. Rosenwald, Paramount Capital, Aries Domestic and Aries
               Trust and their respective officers, directors, general
               partners, investment managers, or trustees have not been,
               during the five years prior to the date hereof, parties to a
               civil proceeding of a judicial or administrative body of
               competent juris diction, as a result of which such person
               was or is subject to a judgment, decree or final order
               enjoining future violations of, or prohibiting or mandat ing
               activities subject to, Federal or State securities laws or
               finding any violation with respect to such laws.

        (f)    Dr. Rosenwald is a citizen of the United States.

- -------------------
   1      Please see attached Exhibit B indicating the executive officers
          and directors of Paramount Capital and providing information
          called for by Items 2-6 of this statement as to said officers and
          directors. Exhibit B is herein incorporated by reference.

   2      Please see attached Exhibit C indicating the general partner of
          Aries Domestic and the general partner's executive officers and
          directors and providing information called for by Items 2-6 of
          this statement as to said general partners, officers and
          directors. Exhibit C is herein incorporated by reference. 

   3      Please see attached Exhibit D indicating the investment manager
          of the Aries Trust and the investment manager's executive
          officers and direc tors and providing information called for by
          Items 2-6 of this statement as to said investment manager and
          officers and directors. Exhibit D is herein incorporated by
          reference.


Item 3.        Source and Amount of Funds or Other Consideration.

               As previously reported in the original statement on Schedule
               13-D (the "Original Statement") filed by the Reporting
               Parties on January 22, 1996, in connection with their
               initial acquisition of shares of the Issuer, Aries Domestic
               used its general funds to effect its initial purchase of
               894,666 shares of the Issuer for an approximate purchase
               price of $1,367,019 and Aries Trust used its general funds
               to effect its initial purchase of 896,666 shares for an
               approximate purchase price of $1,373,663. Since the date of
               the Original Statement, Aries Domestic and Aries Trust have
               used their general funds to effect certain purchases of the
               securities of the Issuer in open market transactions. On
               October 18, 1996, pursuant to a private placement, Aries
               Domestic used its general funds to effect an additional
               purchase of 75,000 newly issued shares and warrants to
               purchase 37,500 shares of the Issuer directly from the
               Issuer for an approximate purchase price of $150,000 and
               Aries Trust used its general funds to effect an additional
               purchase of 175,000 newly issued shares and warrants to
               purchase 87,500 shares of the Issuer directly from the
               Issuer for an approximate purchase price of $350,000.

Item 4.        Purpose of Transaction.

               The Reporting Parties acquired shares of Common Stock and
               Warrants of the Issuer as an investment in the Issuer.

               Although the Reporting Parties have not formulated any
               definitive plans, they may from time to time acquire, or
               dispose of, Common Stock and/or other securi ties of the
               Issuer if and when they deem it appropriate. The Reporting
               Parties may formulate other purposes, plans or proposals
               relating to any of such securities of the Issuer to the
               extent deemed advisable in light of market conditions,
               investment policies and other factors.

               Except as indicated in this Schedule 13D, the Reporting
               Parties currently have no plans or proposals that relate to
               or would result in any of the matters described in
               subparagraphs (a) through (j) of Item 4 of Schedule 13D.

Item 5.        Interest in Securities of the Issuer.

               (a)    As of October 18, 1996, Dr. Rosenwald and Paramount
                      Capital, through acquisition of the shares by the
                      Aries Trust and Aries Domestic, benefi cially owned
                      2,367,134 shares or 7.5% of the Issuer's securities
                      and Aries Domestic and the Aries Trust beneficially
                      owned as follows:

                                                          Amount Owned
                      Aries Domestic                     1,064,367 Shares
                      Aries Trust                        1,302,367 Shares

               (b)    Dr. Rosenwald and Paramount Capital share the power
                      to vote or to direct the vote, to dispose or to
                      direct the disposition of those shares owned by each
                      of Aries Domestic and Aries Trust.

               (c)    As set forth in Item 4, and as previously reported in
                      the Original State ment, the Aries Trust and Aries
                      Domestic purchased 375,000 shares of the Issuer on
                      October 9, 1996, pursuant to a private placement. The
                      following purchases were made by Aries Domestic in
                      the open market in the sixty days prior to October
                      29, 1996:

                      10/17/96            3,000          2.375
                      10/21/96            1,500          2.438
                      10/22/96            3,000          2.438
                      10/28/96            4,500          2.188
                      10/29/96            1,500          2.188

                      The following purchases were made by Aries Trust in
                      the open market in the sixty days prior to October
                      29, 1996:

                          Date      No. of Shares         Market Price
                          ----      -------------         ------------
                      10/17/96         6,000                2.375
                      10/21/96         3,500                2.438
                      10/22/96         8,000                2.438
                      10/28/96        10,500                2.188
                      10/29/96         3,500                2.188


                      Other than as set forth herein the Reporting Parties
                      have not engaged in any transactions in the Common
                      Stock of the Issuer during the past 60 days.

               (d) & (Not applicable.


Item 6.        Contracts, Arrangements, Understandings or Relationships
               with respect to Securities of the Issuer

               Paramount Capital is the investment manager of the Aries
               Trust and the General Partner of Aries Domestic and in such
               capacities has the authority to make certain investment
               decisions on behalf of such entities, including decisions
               relating to the securities of the Issuer. In connection with
               its investment management duties, Paramount Capital receives
               certain management fees and performance allocations from the
               Aries Trust and Aries Domestic. Dr. Rosenwald is the sole
               shareholder of Paramount Capital. Except as indicated in
               this 13D and exhibits, there is no contract, arrangement,
               understanding or relationship between the Reporting Parties
               and any other person, with respect to any securi ties of the
               Issuer.


Item 7.        Material to be Filed as Exhibits:

Exhibit A  -   Copy of an Agreement between Dr. Rosenwald, Paramount
               Capital, Aries Domestic and Aries Trust to file this
               Statement on Schedule 13D on behalf of each of them.

Exhibit B  -   List of executive officers and directors of Paramount
               Capital and information called for by Items 2-6 of this
               statement relating to said officers and direc tors.

Exhibit C  -   List of executive officers and directors of Aries Domestic
               and information called for by Items 2-6 of this statement
               relating to said officers and direc tors.

Exhibit D  -   List of executive officers and directors of Aries Trust and
               information called for by Items 2-6 of this statement
               relating to said officers and directors.


                                 SIGNATURES


               After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.


                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  October 18, 1996
        New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                         Lindsay A. Rosenwald, M.D.
                                         President


                                  ARIES DOMESTIC FUND
                                  By  Paramount Capital Asset Management, Inc.
                                      General Partner

Dated:  October 18, 1996
        New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                         Lindsay A. Rosenwald, M.D.
                                         President


                                  THE ARIES TRUST
                                  By Paramount Capital Asset Management, Inc.
                                       Investment Manager

Dated:  October 18, 1996
        New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                         Lindsay A. Rosenwald, M.D.
                                         President


Dated:  October 18, 1996
        New York, NY              By  /s/ Lindsay A. Rosenwald, M.D.
                                          Lindsay A. Rosenwald, M.D.





                                 EXHIBIT A

                                 AGREEMENT

                        JOINT FILING OF SCHEDULE 13D


               The undersigned hereby agrees to jointly prepare and file
with regulatory authorities a Schedule 13D and any future amendments
thereto reporting each of the undersig ned's ownership of securities of
Cypress Bioscience, Inc., and hereby affirm that such Schedule 13D is being
filed on behalf of each of the undersigned.


                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  October 18, 1996
        New York, NY              By /s/ Lindsay A. Rosenwald. M.D.
                                         Lindsay A. Rosenwald, M.D.
                                         President


                                  ARIES DOMESTIC FUND, L.P.
                                  By Paramount Capital Asset Management, Inc.
                                       General Partner

Dated:  October 18, 1996
        New York, NY              By /s/ Lindsay A. Rosenwald   M.D.
                                         Lindsay A. Rosenwald, M.D.
                                         President


                                  THE ARIES TRUST
                                  By Paramount Capital Asset Management, Inc.
                                       Investment Manager

Dated:  October 18, 1996
        New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                         Lindsay A. Rosenwald, M.D.
                                         President

Dated:  October 18, 1996
        New York, NY              By  /s/ Lindsay Rosenwald, M.D.
                                          Lindsay A. Rosenwald, M.D.



                                
                                 EXHIBIT B

               The name and principal occupation or employment, which in
each instance is with Paramount Capital Asset Management, Inc. ("Paramount
Capital") located at 787 Seventh Avenue, 44th Floor, New York, New York,
10019, of each executive officer and director of Paramount Capital is as
follows:

                                                 PRINCIPAL OCCUPATION
        NAME                                        OR EMPLOYMENT

Lindsay A. Rosenwald, M.D.      Chairman of the Board, President of Para
                                mount Capital Asset Management, Inc., Para
                                mount Capital LLC and Paramount Capital,
                                Inc.

Peter Morgan Kash               Director of Paramount Capital Asset Manage
                                ment, Inc., Inc., Senior Managing Director,
                                Paramount Capital, Inc.

Dr. Yuichi Iwaki                Director of Paramount Capital Asset Manage
                                ment, Inc., Inc., Professor, University of
                                Southern California School of Medicine


Item 2.

               During the five years prior to the date hereof, none of the
above persons (to the best of Paramount Capital's knowledge) was convicted
in a criminal proceeding (excluding traffic violations or similar
misdemeanors) or was a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction, as a result of which such
person was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to,
Federal or State securities laws or finding any violation with respect to
such laws.

Items 3-6.

               Please refer to Items 3-6 herein reporting the beneficial
ownership.




                                 EXHIBIT C

               The name and principal occupation or employment, which is
located at 787 Seventh Avenue, 44th Floor, New York, New York, 10019, of
the General Partner of Aries Domestic is as follows:

                                                PRINCIPAL OCCUPATION
        NAME                                        OR EMPLOYMENT

Paramount Capital Asset Management, Inc.   General Partner; Investment Manager

        Exhibit B is hereby incorporated by reference.

Item 2.

               During the five years prior to the date hereof, the above
person (to the best of Aries Domestic's knowledge) has not been convicted
in a criminal proceeding (excluding traffic violations or similar
misdemeanors) or was a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction, as a result of which such
person was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to,
Federal or State securities laws or finding any violation with respect to
such laws.

Items 3-6.

               Please refer to Items 3-6 herein reporting the beneficial
ownership.




                                 EXHIBIT D

               The name and principal occupation or employment, which in
each instance is with The Aries Trust ("Aries Trust") located at 787
Seventh Avenue, 44th Floor, New York, New York, 10019, of each executive
officer and director of Aries Trust is as follows:

                                                PRINCIPAL OCCUPATION
        NAME                                        OR EMPLOYMENT

Paramount Capital Asset Management, Inc.       Investment Manager

MeesPierson (Cayman) Limited                   Trustee

        Exhibit B is hereby incorporated by reference.

Item 2.

               During the five years prior to the date hereof, neither of
the above persons (to the best of Aries Trust's knowledge) have been
convicted in a criminal proceeding (excluding traffic violations or similar
misdemeanors) or was a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction, as a result of which such
person was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to,
Federal or State securities laws or finding any violation with respect to
such laws.

Items 3-6.

               Please refer to Items 3-6 herein reporting the beneficial
ownership.





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