CYPRESS BIOSCIENCE INC
SC 13D, 1998-11-12
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934


                            Cypress Bioscience, Inc.
                            ------------------------
                                (Name of Issuer)


                     Common Stock, par value $.02 per share
                     --------------------------------------
                         (Title of Class of Securities)

                                  2 232674 101
                                  ------------
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300
                                 with a copy to:

                              David R. Walner, Esq.
                    Paramount Capital Asset Management, Inc.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4372
                         -------------------------------
       (Name, Address and Telephone Number of Person Authorized to Receive
                          Notices and Communications)


                                October 30, 1998
                                ----------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:  [X]
                                                                     
Check the following box if a fee is being paid with this Statement:  [  ]


                                        1

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 2 232674 101                                        Page 2 of 14 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          8,064,135
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        8,064,135
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         8,064,135
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         20.3%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         CO
- --------------------------------------------------------------------------------

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 2 232674 101                                        Page 3 of 14 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          2,410,000
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        2,410,000
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         2,410,000
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         6.0%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 2 232674 101                                        Page 4 of 14 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    The Aries Trust
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          5,654,135
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        5,654,135
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         5,654,135
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         14.2%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         OO
- --------------------------------------------------------------------------------

<PAGE>



                                  SCHEDULE 13D
CUSIP No. 2 232674 101                                        Page 5 of 14 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION
    United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          8,064,135
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        8,064,135
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         8,064,135
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         20.3%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------

<PAGE>

Item 1.  Security and Issuer.

         (a)      Common Stock, $.001 par value ("Shares")

                  Cypress Bioscience, Inc. (the "Issuer")
                  4350 Executive Drive, Suite 325
                  San Diego, CA 92121
                  (619) 452-2323

Item 2.  Identity and Background.

         Names of Persons Filing:

         (a)      This  statement is filed on behalf of Paramount  Capital Asset
                  Management,  Inc. ("Paramount Capital"),  Aries Domestic Fund,
                  L.P. ("Aries  Domestic"),  The Aries Trust ("Aries Trust") and
                  Lindsay A. Rosenwald,  M.D. ("Dr. Rosenwald" and collectively,
                  "Reporting  Parties").  See attached Exhibit A which is a copy
                  of their agreement in writing to file this statement on behalf
                  of each of them.

         (b)      Paramount  Capital's,  Aries  Domestic's  and Dr.  Rosenwald's
                  business address is 787 Seventh Avenue,  48th Floor, New York,
                  New York,  10019.  The business address for Aries Trust is c/o
                  MeesPierson (Cayman) Limited,  P.O. Box 2003, British American
                  Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

         (c)      Dr.  Rosenwald is an investment  banker,  venture  capitalist,
                  fund manager and sole  shareholder of  Paramount Capital,/1/ a
                  Subchapter S corporation  incorporated in Delaware.  Paramount
                  Capital is the General Partner of Aries Domestic,/2/ a limited
                  partnership incorporated in Delaware. Paramount Capital is the
                  Investment Manager to Aries Trust,/3/ a Cayman Islands Trust.

         (d)      Dr.  Rosenwald,  Paramount  Capital,  Aries Domestic and Aries
                  Trust and  their  respec  tive  officers,  directors,  general
                  partners,  investment  managers,  or trustees have not, during
                  the five years prior to the date hereof,  been  convicted in a
                  criminal  proceeding  (excluding traffic violations or similar
                  misdemeanors).

         (e)      Dr.  Rosenwald,  Paramount  Capital,  Aries Domestic and Aries
                  Trust  and  their  respective  officers,   directors,  general
                  partners,  investment  managers,  or  trustees  have not been,
                  during the five years prior to the date  hereof,  parties to a
                  civil  proceeding  of a  judicial  or  administrative  body of
                  competent  jurisdiction,  as a result of which such person was
                  or is subject to a judgment,  decree or final order  enjoining
                  future  violations of, or prohibiting or mandating  activities
                  subject to,
- --------

/1/  Please  see  attached  Exhibit B  indicating  the  executive  officers  and
     directors  of Paramount  Capital and  providing  information  called for by
     Items 2-6 of this statement as to said officers and directors. Exhibit B is
     herein incorporated by reference.

/2/  Please see  attached  Exhibit C  indicating  the  general  partner of Aries
     Domestic and the general  partner's  executive  officers and  directors and
     providing  information called for by Items 2-6 of this statement as to said
     general partners, officers and directors.  Exhibit C is herein incorporated
     by reference.

/3/  Please see attached  Exhibit D  indicating  the  investment  manager of the
     Aries Trust and the investment  manager's executive officers and direc tors
     and providing  information  called for by Items 2-6 of this statement as to
     said  investment  manager and officers and  directors.  Exhibit D is herein
     incorporated by reference.


                                       6

<PAGE>

     Federal or State  securities  laws or finding any violation with respect to
     such laws.

         (f) Dr. Rosenwald is a citizen of the United States.

Item 3.  Source and Amount of Funds or Other Consideration.

On December  28,  1995,  Aries  Domestic  used its  general  funds to effect the
purchase of 166,667 shares of the Issuer for an approximate  aggregate  purchase
price of  $235,000.47  and the Aries Trust used its general  funds to effect the
purchase of 166,667 shares of the Issuer for an approximate  aggregate  purchase
price of $235,000.47.

On January 18, 1996 Aries Domestic used its general funds to effect the purchase
of 500,000 Shares of the Issuer for an approximate  aggregate  purchase price of
$705,000  and the Aries Trust used its general  funds to effect the  purchase of
500,000  Shares of the Issuer for an  approximate  aggregate  purchase  price of
$705,000.

On January 25, 1996 Aries Domestic used its general funds to effect the purchase
of 200,000 Shares of the Issuer for an approximate  aggregate  purchase price of
$282,000  and the Aries Trust used its general  funds to effect the  purchase of
200,000  Shares of the Issuer for an  approximate  aggregate  purchase  price of
$282,000.

On September 26, 1996, in a private placement of the Issuer's securities,  Aries
Domestic used its general funds to effect an additional purchase of 75,000 newly
issued shares and warrants to purchase 37,500 Shares of the Issuer directly from
the Issuer for an  approximate  purchase  price of $150,000 and Aries Trust used
its  general  funds to effect an  additional  purchase of 175,000  newly  issued
shares and warrants to purchase  87,500  shares of the Issuer  directly from the
Issuer for an approximate purchase price of $350,000.

On November 19, 1996, in a private transaction, the Aries Trust acquired 350,000
Shares  from Aries  Domestic  for an  approximate  aggregate  purchase  price of
$667,436.

On September 30, 1997, in a private placement of the Issuer's securities,  Aries
Domestic  used its general  funds to purchase  440,000  Shares of the Issuer for
$1.50 per share and an approximate  aggregate  purchase cost of $660,000 and the
Aries Trust used its general funds to purchase  893,334  Shares of the Issuer in
the  Private  Placement  for an  approximate  aggregate  purchase  cost equal to
$1,340,001.

On September 16, 1998, in a private placement of the Issuer's securities,  Aries
Domestic  used  its  general  funds  to  purchase  173,333  shares  of  Series A
Convertible  Preferred  Stock  (the  "Preferred  Stock")  of the  Issuer  for an
approximate  aggregate purchase cost of $259,999.  Each share of Preferred Stock
is initially convertible into one share of common stock at an initial conversion
price equal to $1.50 per share.  In the same  private  placement of the Issuer's
securities,  Aries Trust used its general  funds to purchase  493,334  shares of
Preferred  Stock of the Issuer for an  approximate  aggregate  purchase  cost of
$740,001.  Each share of Preferred Stock is initially convertible into one share
of common stock at an initial conversion price equal to $1.50 per share.

Aries  Domestic  has used its general  funds to acquire  through the open market
1,167,500  Shares of the Issuer for an approximate  aggregate  purchase price of
$2,766,534.19  and the Aries Trust has used its general funds to acquire through
the open  market  2,788,300  Shares of the Issuer for an  approximate  aggregate
purchase price of $6,709,231.13.

Item 4.  Purpose of Transaction.

     The Reporting  Parties  acquired shares of Common Stock and Warrants of the
     Issuer as an investment in the Issuer.

     Although the Reporting  Parties have not formulated  any definitive  plans,
     they may from time to time  acquire,  or dispose of,  Common  Stock  and/or
     other  securities of the Issuer if and when they deem it  appropriate.  The
     Reporting Parties may formulate other purposes, plans or proposals relating
     to any of such  securities of the Issuer to the extent deemed  advisable in
     light of market conditions, investment policies and other factors.

     Except as indicated in this Schedule 13D, the Reporting  Parties  currently
     have no plans or  proposals  that  relate to or would  result in any of the
     matters  described in  subparagraphs  (a) through (j) of Item 4 of Schedule
     13D.


                                        7

<PAGE>

Item 5.  Interest in Securities of the Issuer.

     (a)  As of November 9, 1998, Dr. Rosenwald and Paramount  Capital,  through
          acquisi  tion of the  shares  by the Aries  Trust and Aries  Domestic,
          beneficially   owned  8,064,135   shares  or  20.3%  of  the  Issuer's
          securities and Aries Domestic and the Aries Trust  beneficially  owned
          as follows:

                                Amount Owned
                                ------------
           Aries Domestic                     2,410,000 Shares
           Aries Trust                        5,654,135 Shares

     (b)  Dr.  Rosenwald  and  Paramount  Capital  share the power to vote or to
          direct the vote,  to dispose  or to direct  the  disposition  of those
          shares owned by each of Aries Domestic and Aries Trust.

     (c)  The following purchases were made by Aries Domestic in the open market
          in the sixty days prior to this filing:

          Date                        Amount            Price
          ----                        ------            -----
          09/10/98                     2,600            1.563
          09/10/98                     2,600            1.531
          09/10/98                     2,600            1.563
          09/30/98                    15,600            2.836
          10/02/98                     5,200            2.794
          10/07/98                     4,900            2.550
          10/08/98                     2,800            2.481
          10/09/98                     6,500            2.667
          10/12/98                     2,600            2.608
          10/13/98                     2,600            2.622
          10/14/98                     3,900            2.681
          10/15/98                     2,600            2.760


                                        8

<PAGE>

          10/16/98                     5,900            2.803
          10/20/98                     2,600            2.854
          10/28/98                     2,600            2.909
          10/30/98                    10,400            3.029
          10/30/98                    18,200            3.086
          11/03/98                     3,900            2.896
          11/04/98                     1,300            2.875
          11/05/98                     5,200            2.818
          11/06/98                     9,100            2.818
          11/06/98                     3,500            2.750
          11/09/98                     2,600            2.656

          The following purchases were made by Aries Trust in the open market in
          the sixty days prior to the date of this filing:

          Date                        Amount            Price
          ----                        ------            -----
          09/10/98                     7,400            1.531
          09/10/98                     7,400            1.563
          09/28/98                    30,000            2.531
          09/29/98                    30,000            2.640
          09/30/98                    44,400            2.836
          10/02/98                    14,800            2.794
          10/07/98                    14,000            2.550
          10/08/98                     8,300            2.481
          10/09/98                    18,500            2.667
          10/12/98                     7,400            2.608
          10/13/98                     7,400            2.622
          10/14/98                    11,100            2.681
          10/15/98                     7,400            2.760
          10/16/98                    14,800            2.803
          10/20/98                     7,400            2.854
          10/28/98                     7,400            2.909
          10/30/98                    29,600            3.029
          10/30/98                    51,800            3.086
          11/03/98                    11,100            2.896
          11/04/98                     3,700            2.875
          11/05/98                    14,800            2.818
          11/06/98                    25,900            2.818
          11/06/98                    10,000            2.750
          11/09/98                     7,400            2.656

          Other than as set forth herein the Reporting  Parties have not engaged
          in any  transactions  in the Common Stock of the Issuer since the last
          filing.

          (d) & (e)         Not applicable.


Item 6.  Contracts, Arrangements, Understandings or Relationships with respect 
         to Securities of the Issuer

          Paramount Capital is the investment manager of the Aries Trust and the
          General  Partner  of Aries  Domestic  and in such  capacities  has the
          authority  to make  certain  investment  decisions  on  behalf of such
          entities,  including  decisions  relating  to  the  securities  of the
          Issuer. In connection with its investment management duties, Paramount
          Capital receives certain  management fees and performance  allocations
          from the Aries Trust and Aries  Domestic.  Dr.  Rosenwald  is the sole
          shareholder of Paramount Capital.  Except as indicated in this 13D and
          exhibits,  there  is  no  contract,   arrangement,   understanding  or
          relationship  between the Reporting Parties and any other person, with
          respect to any securities of the Issuer.


                                        9

<PAGE>

Item 7.  Material to be Filed as Exhibits:

Exhibit A - Copy of an Agreement between Dr. Rosenwald, Paramount Capital, Aries
            Domestic  and Aries Trust to file this  Statement on Schedule 13D on
            behalf of each of them.

Exhibit B - List of executive  officers and  directors of Paramount  Capital and
            information  called  for by Items 2-6 of this  statement  relating  
            to said officers and directors.

Exhibit C - List of  executive  officers  and  directors  of Aries  Domestic and
            information  called  for by Items 2-6 of this  statement  relating  
            to said officers and directors.

Exhibit D - List  of  executive  officers  and  directors  of  Aries  Trust  and
            information  called  for by Items 2-6 of this  statement  relating  
            to said officers and directors.


                                       10

<PAGE>

                                   SIGNATURES


     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


                                   PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   November 9, 1998
         New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                   ARIES DOMESTIC FUND
                                   By  Paramount Capital Asset Management, Inc.
                                       General Partner

Dated:   November 9, 1998
         New York, NY              By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      Chairman


                                    THE ARIES TRUST
                                    By Paramount Capital Asset Management, Inc.
                                       Investment Manager

Dated:   November 9, 1998
         New York, NY               By /s/ Lindsay A. Rosenwald, M.D.
                                       ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       Chairman


Dated:   November 9, 1998
         New York, NY               By  /s/ Lindsay A. Rosenwald, M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.


                                       11

<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D

     The  undersigned  hereby agrees to jointly prepare and file with regulatory
authorities a Schedule 13D and any future  amendments  thereto reporting each of
the  undersigned's  ownership of securities  of Cypress  Bioscience,  Inc.,  and
hereby  affirm  that such  Schedule  13D is being filed on behalf of each of the
undersigned.


                                 PARAMOUNT CAPITAL ASSET MANAGEMENT, INC., INC.

Dated:   November 9, 1998
         New York, NY            By /s/ Lindsay A. Rosenwald. M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman


                                 ARIES DOMESTIC FUND, L.P.
                                 By Paramount Capital Asset Management, Inc.
                                    General Partner

Dated:   November 9, 1998
         New York, NY            By /s/ Lindsay A. Rosenwald M.D.
                                    -----------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman


                                 THE ARIES TRUST
                                 By Paramount Capital Asset Management, Inc.
                                    Investment Manager

Dated:   November 9, 1998
         New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman

Dated:   November 9, 1998
         New York, NY            By  /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------
                                     Lindsay A. Rosenwald, M.D.


                                       12

<PAGE>

                                    EXHIBIT B

     The name and principal occupation or employment,  which in each instance is
with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located at
787 Seventh  Avenue,  48th Floor,  New York, New York,  10019, of each executive
officer and director of Paramount Capital is as follows:

                                            PRINCIPAL OCCUPATION
         NAME                                  OR EMPLOYMENT
         ----                                  -------------

Lindsay A. Rosenwald, M.D.       Chairman of the Board of Paramount Capital
                                 Asset Management, Inc., Paramount Capital
                                 Investments, LLC and Paramount Capital, Inc.

Mark C. Rogers, M.D.             President of Paramount Capital Asset
                                 Management, Inc., Paramount Capital
                                 Investments, LLC and Paramount Capital, Inc.

Peter Morgan Kash                Director of Paramount Capital Asset
                                 Management, Inc., Senior Managing Director,
                                 Paramount Capital, Inc.

Dr. Yuichi Iwaki                 Director of Paramount Capital Asset
                                 Management, Inc., Professor, University of
                                 Southern California School of Medicine


Item 2.

     During the five years prior to the date hereof,  none of the above  persons
(to the best of  Paramount  Capital's  knowledge)  was  convicted  in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       13

<PAGE>

                                    EXHIBIT C

     The name and principal  occupation or  employment,  which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic is as follows:

                                              PRINCIPAL OCCUPATION
         NAME                                     OR EMPLOYMENT
         ----                                     -------------

Paramount Capital Asset Management, Inc.     General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

     During the five years prior to the date  hereof,  the above  person (to the
best of  Aries  Domestic's  knowledge)  has not  been  convicted  in a  criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.


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<PAGE>

                                    EXHIBIT D

     The name and principal occupation or employment,  which in each instance is
with The Aries Trust ("Aries Trust") located at 787 Seventh Avenue,  48th Floor,
New York, New York, 10019, of each executive officer and director of Aries Trust
is as follows:

                                                PRINCIPAL OCCUPATION
         NAME                                      OR EMPLOYMENT
         ----                                      -------------

Paramount Capital Asset Management, Inc.         Investment Manager

MeesPierson (Cayman) Limited                     Trustee

         Exhibit B is hereby incorporated by reference.

Item 2.

     During  the five  years  prior to the date  hereof,  neither  of the  above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.


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