CYPRESS BIOSCIENCE INC
SC 13D/A, 1998-03-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                        AMENDED AND RESTATED SCHEDULE 13D
                                (Amendment No. 6)


                    Under the Securities Exchange Act of 1934

                            Cypress Bioscience, Inc.
                                (Name of Issuer)


                     Common Stock, par value $.001 per share
                         (Title of Class of Securities)


                                  2 232674 101
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:

                              David R. Walner, Esq.
                    Paramount Capital Asset Management, Inc.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4372



           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)


                                February 25, 1998
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:     |_|

Check the following box if a fee is being paid with this Statement:
                                             |_|

                               Page 1 of 14 pages

<PAGE>

- ------------------------------                    ------------------------------
CUSIP NO. 2 232674 101        13D                     PAGE 2 OF 14 PAGES
- ------------------------------                    ------------------------------
<TABLE>
- ------------------------------------------------------------------------------------------
<S>     <C>                                                                  <C>
1       NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Paramount Capital Asset Management, Inc.
- ------------------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                     (a)|_| (b)|_|

- ------------------------------------------------------------------------------------------
   3    SEC USE ONLY

- ------------------------------------------------------------------------------------------
   4    SOURCE OF FUNDS* OO (see Item 3 below)

- ------------------------------------------------------------------------------------------
   5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
        ITEM 2(d) or 2(e)
                                                                                |_|
- ------------------------------------------------------------------------------------------
   6    CITIZENSHIP OR PLACE OF ORGANIZATION
        Delaware

- ------------------------------------------------------------------------------------------
                                 7    SOLE VOTING POWER
                                      None
          NUMBER OF
           SHARES
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH


                             -------------------------------------------------------------
                                 8    SHARED VOTING POWER
                                      5,530,468
                             -------------------------------------------------------------
                                 9    SOLE DISPOSITIVE POWER
                                      None
                             -------------------------------------------------------------
                                10    SHARED DISPOSITIVE POWER
                                      5,530,468
- ------------------------------------------------------------------------------------------
  11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        5,530,468

- ------------------------------------------------------------------------------------------
  12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                |_|
- ------------------------------------------------------------------------------------------
  13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        15.9%

- ------------------------------------------------------------------------------------------
  14    TYPE OF REPORTING PERSON*
        CO

- ------------------------------------------------------------------------------------------
</TABLE>



<PAGE>

- ------------------------------                    ------------------------------
CUSIP NO. 2 232674 101        13D                     PAGE 3 OF 14 PAGES
- ------------------------------                    ------------------------------
<TABLE>
- ------------------------------------------------------------------------------------------
<S>     <C>                                                                  <C>
   1    NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Aries Domestic Fund, L.P.
- ------------------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                             (a)|_|  (b)|_|
- ------------------------------------------------------------------------------------------
   3    SEC USE ONLY

- ------------------------------------------------------------------------------------------
   4    SOURCE OF FUNDS* OO (see Item 3 below)

- ------------------------------------------------------------------------------------------
   5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
        ITEM 2(d) or 2(e)
                                                                                |_|
- ------------------------------------------------------------------------------------------
   6    CITIZENSHIP OR PLACE OF ORGANIZATION
        Delaware

- ------------------------------------------------------------------------------------------
                                 7    SOLE VOTING POWER
                                      None
          NUMBER OF
           SHARES
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH


                             -------------------------------------------------------------
                                 8    SHARED VOTING POWER
                                      1,737,117
                             -------------------------------------------------------------
                                 9    SOLE DISPOSITIVE POWER
                                      None
                             -------------------------------------------------------------
                                10    SHARED DISPOSITIVE POWER
                                      1,737,117
- ------------------------------------------------------------------------------------------
  11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        1,737,117

- ------------------------------------------------------------------------------------------
  12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                |_|
- ------------------------------------------------------------------------------------------
  13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        5.0%

- ------------------------------------------------------------------------------------------
  14    TYPE OF REPORTING PERSON*
        PN

- ------------------------------------------------------------------------------------------
</TABLE>



<PAGE>

- ------------------------------                    ------------------------------
CUSIP NO. 2 232674 101        13D                     PAGE 4 OF 14 PAGES
- ------------------------------                    ------------------------------
<TABLE>
- ------------------------------------------------------------------------------------------
<S>    <C>                                                                   <C>
  1    NAMES OF REPORTING PERSONS
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       The Aries Trust
- ------------------------------------------------------------------------------------------
  2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                             (a)|_| (b)|_|
- ------------------------------------------------------------------------------------------
  3    SEC USE ONLY

- ------------------------------------------------------------------------------------------
  4    SOURCE OF FUNDS* 
       OO (see Item 3 below)

- ------------------------------------------------------------------------------------------
  5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
       ITEM 2(d) or 2(e)
                                                                                |_|
- ------------------------------------------------------------------------------------------
  6    CITIZENSHIP OR PLACE OF ORGANIZATION
       Cayman Islands

- ------------------------------------------------------------------------------------------
                                 7    SOLE VOTING POWER
                                      None
          NUMBER OF
           SHARES
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH


                             -------------------------------------------------------------
                                 8    SHARED VOTING POWER
                                      3,791,351
                             -------------------------------------------------------------
                                 9    SOLE DISPOSITIVE POWER
                                      None
                             -------------------------------------------------------------
                                10    SHARED DISPOSITIVE POWER
                                      3,793,351
- ------------------------------------------------------------------------------------------
  11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       3,793,351

- ------------------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                |_|
- ------------------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
       10.9

- ------------------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON* OO (see Item 2)

- ------------------------------------------------------------------------------------------
</TABLE>



<PAGE>

- ------------------------------                    ------------------------------
CUSIP NO. 2 232674 101        13D                     PAGE 5 OF 14 PAGES
- ------------------------------                    ------------------------------
<TABLE>
- ------------------------------------------------------------------------------------------
<S>     <C>                                                                     <C>
   1    NAMES OF REPORTING PERSONS
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Lindsay A. Rosenwald, M.D.
- ------------------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                (a)|_|
                                                                                (b)|_|
- ------------------------------------------------------------------------------------------
   3    SEC USE ONLY

- ------------------------------------------------------------------------------------------
   4    SOURCE OF FUNDS* OO (see Item 3 below)

- ------------------------------------------------------------------------------------------
   5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
        ITEM 2(d) or 2(e)
                                                                                |_|
- ------------------------------------------------------------------------------------------
   6    CITIZENSHIP OR PLACE OF ORGANIZATION
        United States

- ------------------------------------------------------------------------------------------
                                 7    SOLE VOTING POWER
                                      None
          NUMBER OF
           SHARES
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH
                             -------------------------------------------------------------
                                 8    SHARED VOTING POWER
                                      5,530,468
                             -------------------------------------------------------------
                                 9    SOLE DISPOSITIVE POWER
                                      None
                             -------------------------------------------------------------
                                10    SHARED DISPOSITIVE POWER
                                      5,530,468
- ------------------------------------------------------------------------------------------
  11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        5,530,468

- ------------------------------------------------------------------------------------------
  12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                |_|
- ------------------------------------------------------------------------------------------
  13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        15.9%

- ------------------------------------------------------------------------------------------
  14    TYPE OF REPORTING PERSON*
        IN

- ------------------------------------------------------------------------------------------
</TABLE>



<PAGE>

Item 1.     Security and Issuer.

      (a)   Common Stock, $.001 par value ("Shares")

            Cypress Bioscience, Inc. (the "Issuer")
            4350 Executive Drive, Suite 325
            San Diego, CA 92121
            (619) 452-2323

Item 2.     Identity and Background.

      Names of Persons Filing:

      (a)   This  statement  is filed  on  behalf  of  Paramount  Capital  Asset
            Management,  Inc. ("Paramount  Capital"),  Aries Domestic Fund, L.P.
            ("Aries  Domestic"),  The Aries Trust ("Aries Trust") and Lindsay A.
            Rosenwald,  M.D.  ("Dr.  Rosenwald"  and  collectively,   "Reporting
            Parties"). See attached Exhibit A which is a copy of their agreement
            in writing to file this statement on behalf of each of them.

      (b)   Paramount  Capital's,  Aries Domestic's and Dr. Rosenwald's business
            address is 787  Seventh  Avenue,  48th  Floor,  New York,  New York,
            10019.  The  business  address  for Aries  Trust is c/o  MeesPierson
            (Cayman) Limited,  P.O. Box 2003, British American Centre,  Phase 3,
            Dr. Roy's Drive, George Town, Grand Cayman.

      (c)   Dr.  Rosenwald is an investment  banker,  venture  capitalist,  fund
            manager and sole shareholder of Paramount  Capital/1/ a Subchapter S
            corporation  incorporated  in  Delaware.  Paramount  Capital  is the
            General   Partner  of  Aries   Domestic/2/  a  limited   partnership
            incorporated  in  Delaware.  Paramount  Capital  is  the  Investment
            Manager to Aries Trust/3/ a Cayman Islands Trust.

- --------

      /1/   Please see attached Exhibit B indicating the executive  officers and
            directors of Paramount Capital and providing  information called for
            by Items 2-6 of this  statement as to said  officers and  directors.
            Exhibit B is herein incorporated by reference.

      /2/   Please see  attached  Exhibit C  indicating  the general  partner of
            Aries  Domestic  and the general  partner's  executive  officers and
            directors and providing  information called for by Items 2-6 of this
            statement  as to said  general  partners,  officers  and  directors.
            Exhibit C is herein incorporated by reference.

      /3/   Please see attached  Exhibit D indicating the investment  manager of
            the Aries Trust and the investment  manager's executive officers and
            directors and providing  information called for by Items 2-6 of this
            statement as to said investment  manager and officers and directors.
            Exhibit D is herein incorporated by reference.


                                     - 6 -
<PAGE>

      (d)   Dr. Rosenwald, Paramount Capital, Aries Domestic and Aries Trust and
            their respective officers,  directors, general partners,  investment
            managers,  or trustees have not,  during the five years prior to the
            date  hereof,  been  convicted in a criminal  proceeding  (excluding
            traffic violations or similar misdemeanors).

      (e)   Dr. Rosenwald, Paramount Capital, Aries Domestic and Aries Trust and
            their respective officers,  directors, general partners,  investment
            managers,  or trustees have not been, during the five years prior to
            the date  hereof,  parties to a civil  proceeding  of a judicial  or
            administrative body of competent jurisdiction,  as a result of which
            such person was or is subject to a  judgment,  decree or final order
            enjoining   future   violations  of,  or  prohibiting  or  mandating
            activities  subject to, Federal or State  securities laws or finding
            any violation with respect to such laws.

      (f)   Dr. Rosenwald is a citizen of the United States.

Item 3.     Source and Amount of Funds or Other Consideration.

            Since January 28, 1998, the date of Amendment No. 5 ("Amendment  No.
            5") to  the  original  statement  on  Schedule  13D  (the  "Original
            Statement"),  the  Aries  Domestic  used its  general  funds to make
            certain open market acquisitions of the securities of the Issuer and
            the Aries Trust used its general  funds to make  certain open market
            acquisitions of the securities of the Issuer as more fully set forth
            in Item 5.

Item 4.     Purpose of Transaction.

            The Reporting  Parties  acquired shares of Common Stock and Warrants
            of the Issuer as an investment in the Issuer.

            Although the Reporting  Parties have not  formulated  any definitive
            plans,  they may from time to time  acquire,  or dispose of,  Common
            Stock and/or other securities of the Issuer if and when they deem it
            appropriate.  The Reporting  Parties may formulate  other  purposes,
            plans or proposals  relating to any of such securities of the Issuer
            to the  extent  deemed  advisable  in  light of  market  conditions,
            investment policies and other factors.

            Except as indicated in this  Schedule  13D,  the  Reporting  Parties
            currently  have no plans or proposals that relate to or would result
            in any of the matters  described in subparagraphs (a) through (j) of
            Item 4 of Schedule 13D.


                                     - 7 -
<PAGE>

Item 5.     Interest in Securities of the Issuer.

            (a)   As of February 26, 1998, Dr. Rosenwald and Paramount  Capital,
                  through acquisition of the shares by the Aries Trust and Aries
                  Domestic,  beneficially owned 5,530,468 shares or 15.9% of the
                  Issuer's  securities  and Aries  Domestic  and the Aries Trust
                  beneficially owned as follows:

                                                Amount Owned
                                                ------------
                  Aries Domestic                1,737,117 Shares
                  Aries Trust                   3,793,351 Shares

            (b)   Dr. Rosenwald and Paramount Capital share the power to vote or
                  to direct the vote, to dispose or to direct the disposition of
                  those shares owned by each of Aries Domestic and Aries Trust.

            (c)   The  following  purchases  were made by Aries  Domestic in the
                  open market in the sixty days prior to February 26, 1998:

                  Date                    Amount            Price
                  ----                    ------            -----
                  01/30/98                 8,300            2.934
                  02/02/98                 8,500            2.794
                  02/03/98                13,600            2.613
                  02/04/98                 5,000            2.625
                  02/06/98                 5,000            2.625
                  02/10/98                11,600            2.603
                  02/12/98                10,000            2.734
                  02/13/98                 3,300            2.813
                  02/17/98                13,300            2.781
                  02/17/98                 6,700            2.688
                  02/18/98                10,000            2.735
                  02/23/98                 6,700            2.625
                  02/24/98                 3,300            2.719
                  02/25/98                 3,300            2.625
                  02/25/98                 6,600            2.656
                  02/25/98                 6,600            2.688

                  The following  purchases  were made by Aries Trust in the open
                  market in the sixty days prior to February 26, 1998

                  Date                    Amount            Price
                  ----                    ------            -----
                  01/30/98                 8,300            2.934
                  02/02/98                 8,500            2.794
                  02/03/98                13,600            2.613
                  02/04/98                 5,000            2.625
                  02/06/98                 5,000            2.625
                  02/10/98                11,600            2.603
                  02/12/98                10,000            2.734
                  02/13/98                 3,300            2.813
                  02/17/98                13,300            2.781


                                     - 8 -
<PAGE>

                  02/17/98                 6,700            2.688
                  02/18/98                10,000            2.735
                  02/23/98                 6,700            2.625
                  02/24/98                 3,300            2.719
                  02/25/98                 3,300            2.625
                  02/25/98                 6,600            2.656
                  02/25/98                 6,600            2.688

            Other  than as set  forth  herein  the  Reporting  Parties  have not
            engaged in any  transactions in the Common Stock of the Issuer since
            the last filing.

            (d) & (e) Not applicable.


Item 6.     Contracts, Arrangements, Understandings or
            Relationships
            with respect to Securities of the Issuer

            Paramount  Capital is the investment  manager of the Aries Trust and
            the General Partner of Aries Domestic and in such capacities has the
            authority  to make  certain  investment  decisions on behalf of such
            entities,  including  decisions  relating to the  securities  of the
            Issuer.  In  connection  with  its  investment   management  duties,
            Paramount  Capital receives certain  management fees and performance
            allocations  from the Aries Trust and Aries Domestic.  Dr. Rosenwald
            is the sole shareholder of Paramount Capital. Except as indicated in
            this  13D  and   exhibits,   there  is  no  contract,   arrangement,
            understanding or relationship  between the Reporting Parties and any
            other person, with respect to any securities of the Issuer.

Item 7.     Material to be Filed as Exhibits:

Exhibit A - Copy of an Agreement between Dr. Rosenwald, Paramount Capital, Aries
            Domestic  and Aries Trust to file this  Statement on Schedule 13D on
            behalf of each of them.

Exhibit B - List of executive  officers and  directors of Paramount  Capital and
            information  called for by Items 2-6 of this  statement  relating to
            said officers and directors.

Exhibit C - List of  executive  officers  and  directors  of Aries  Domestic and
            information  called for by Items 2-6 of this  statement  relating to
            said officers and directors.

Exhibit D - List  of  executive  officers  and  directors  of  Aries  Trust  and
            information called for by Items 2-6 of


                                     - 9 -
<PAGE>

            this statement relating to said officers and directors.


                                   SIGNATURES


            After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.


                                    PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:      February 26, 1998
            New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                       ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President
                                  
                                  
                                    ARIES DOMESTIC FUND
                                    By Paramount Capital Asset Management, Inc.
                                       General Partner
                                  
Dated:      February 26, 1998     
            New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                       ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President
                                  
                                  
                                    THE ARIES TRUST
                                    By Paramount Capital Asset Management, Inc.
                                       Investment Manager
                                  
Dated:      February 26, 1998     
            New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                       ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President
                                  
                                  
Dated:      February 26, 1998     
            New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                       ------------------------------
                                       Lindsay A. Rosenwald, M.D.


                                     - 10 -
<PAGE>

                                   EXHIBIT A

                                   AGREEMENT

                         JOINT FILING OF SCHEDULE 13D


            The  undersigned  hereby  agrees to  jointly  prepare  and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each  of  the  undersigned's   ownership  of  securities  of  Cypress
Bioscience,  Inc.,  and hereby  affirm that such  Schedule 13D is being filed on
behalf of each of the undersigned.


                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:      February 26, 1998
            New York, NY             By /s/ Lindsay A. Rosenwald. M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President


                                     ARIES DOMESTIC FUND, L.P. 
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:      February 26, 1998
            New York, NY             By /s/ Lindsay A. Rosenwald M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President


                                     THE ARIES TRUST
                                     By Paramount Capital Asset Management, Inc.
                                        Investment Manager

Dated:      February 26, 1998
            New York, NY             By /s/ Lindsay A. Rosenwald, M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President

Dated:      February 26, 1998 
            New York, NY             By /s/ Lindsay A. Rosenwald, M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.


                                     - 11 -
<PAGE>

                                    EXHIBIT B

      The name and principal occupation or employment, which in each instance is
with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located at
787 Seventh  Avenue,  48th Floor,  New York, New York,  10019, of each executive
officer and director of Paramount Capital is as follows:

                                                     PRINCIPAL OCCUPATION
      NAME                                               OR EMPLOYMENT
      ----                                               -------------

Lindsay A. Rosenwald, M.D.                            Chairman of the
                                                      Board, President of
                                                      Paramount Capital
                                                      Asset Management,
                                                      Inc., Paramount
                                                      Capital Investments,
                                                      LLC and Paramount
                                                      Capital, Inc.

Peter Morgan Kash                                     Director of
                                                      Paramount Capital
                                                      Asset Management,
                                                      Inc., Senior Man-
                                                      aging Director, Par-
                                                      amount Capital, Inc.

Dr. Yuichi Iwaki                                      Director of
                                                      Paramount Capital
                                                      Asset Management,
                                                      Inc., Professor,
                                                      University of South-
                                                      ern California
                                                      School of Medicine


Item 2.

      During the five years prior to the date hereof,  none of the above persons
(to the best of  Paramount  Capital's  knowledge)  was  convicted  in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                     - 12 -
<PAGE>

                                    EXHIBIT C

      The name and principal  occupation or employment,  which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic is as follows:

                                                     PRINCIPAL OCCUPATION
      NAME                                               OR EMPLOYMENT
      ----                                               -------------

Paramount Capital Asset Management, Inc.                 General Partner; 
                                                         Investment Manager

      Exhibit B is hereby incorporated by reference.

Item 2.

      During the five years prior to the date  hereof,  the above person (to the
best of  Aries  Domestic's  knowledge)  has not  been  convicted  in a  criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                     - 13 -
<PAGE>

                                   EXHIBIT D

      The name and principal occupation or employment, which in each instance is
with The Aries Trust ("Aries Trust") located at 787 Seventh Avenue,  48th Floor,
New York, New York, 10019, of each executive officer and director of Aries Trust
is as follows:

                                                      PRINCIPAL OCCUPATION
      NAME                                               OR EMPLOYMENT
      ----                                               -------------

Paramount Capital Asset Management, Inc.                  Investment
                                                          Manager

MeesPierson (Cayman) Limited                              Trustee

      Exhibit B is hereby incorporated by reference.

Item 2.

      During  the five  years  prior to the date  hereof,  neither  of the above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                     - 14 -


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