CYPRESS BIOSCIENCE INC
SC 13D/A, 1998-02-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                        SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C.  20549

                                  SCHEDULE 13D
                                (Amendment No. 5)

                    Under the Securities Exchange Act of 1934


                            Cypress Bioscience, Inc.
                                (Name of Issuer)


                     Common Stock, par value $.001 per share
                         (Title of Class of Securities)

                                  2 232674 101
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300
                                 with a copy to:

                              David R. Walner, Esq.
                    Paramount Capital Asset Management, Inc.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4372

       (Name, Address and Telephone Number of Person Authorized to Receive
                           Notices and Communications)


                                January 28, 1998
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:
                                                                        [ ]

Check the following box if a fee is being paid with this Statement:
                                                                        [ ]


                                        1

<PAGE>

                                  SCHEDULE 13D
CUSIP No. 2 232674 101                                        Page 2 of 13 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    
    Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          5,165,468
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        5,165,468
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         5,165,468
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         14.8%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON
         CO
- --------------------------------------------------------------------------------

<PAGE>


                                  SCHEDULE 13D
CUSIP No. 2 232674 101                                        Page 3 of 13 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    
    Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          1,615,317
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        1,615,317
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         1,615,317
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         4.6%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------


<PAGE>


                                  SCHEDULE 13D
CUSIP No. 2 232674 101                                        Page 4 of 13 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    
    The Aries Trust
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION

    Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          3,550,151
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        3,550,151
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         3,550,151
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         10.2%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         OO (see Item 2)
- --------------------------------------------------------------------------------

<PAGE>


                                  SCHEDULE 13D
CUSIP No. 2 232674 101                                        Page 5 of 13 Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    
    Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION

    United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          5,165,468
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        5,165,468
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         5,165,468
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         14.8%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------

<PAGE>

Item 1. Security and Issuer.

        (a)    Common Stock, $.001 par value ("Shares")

               Cypress Bioscience, Inc. (the "Issuer")
               4350 Executive Drive, Suite 325
               San Diego, CA 92121
               (619) 452-2323

Item 2. Identity and Background.

        Names of Persons Filing:

        (a)    This  statement  is filed on behalf of  Paramount  Capital  Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
               ("Aries  Domestic"),  The Aries Trust ("Aries Trust") and Lindsay
               A. Rosenwald, M.D. ("Dr. Rosenwald" and collectively,  "Reporting
               Parties").  See  attached  Exhibit  A which  is a copy  of  their
               agreement in writing to file this  statement on behalf of each of
               them.

        (b)    Paramount   Capital's,   Aries  Domestic's  and  Dr.  Rosenwald's
               business address is 787 Seventh Avenue, 48th Floor, New York, New
               York,  10019.  The  business  address  for  Aries  Trust  is  c/o
               MeesPierson  (Cayman)  Limited,  P.O. Box 2003,  British American
               Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

        (c)    Dr. Rosenwald is an investment banker,  venture capitalist,  fund
               manager  and  sole   shareholder   of  Paramount   Capital,/1/  a
               Subchapter S  corporation  incorporated  in  Delaware.  Paramount
               Capital is the General  Partner of Aries  Domestic,/2/  a limited
               partnership  incorporated in Delaware.  Paramount  Capital is the
               Investment Manager to Aries Trust,/3/ a Cayman Islands Trust.

        (d)    Dr. Rosenwald,  Paramount Capital, Aries Domestic and Aries Trust
               and their  respective  officers,  directors,  general  partners,
               investment managers,  or trustees have not, during the five years
               prior to the date hereof, been convicted in a criminal proceeding
               (excluding traffic violations or similar misdemeanors).

        (e)    Dr. Rosenwald,  Paramount Capital, Aries Domestic and Aries Trust
               and  their  respective  officers,  directors,  general  partners,
               investment  managers,  or trustees have not been, during the five
               years prior to the date hereof,  parties to a civil proceeding of
               a judicial or administrative body of competent jurisdiction, as a
               result of which such  person  was or is  subject  to a  judgment,
               decree  or  final  order  enjoining  future   violations  of,  or
               prohibiting or mandating activities subject to,
- ------------------------------

         /1/        Please  see  attached  Exhibit B  indicating  the  executive
                    officers and  directors of Paramount  Capital and  providing
                    information  called for by Items 2-6 of this statement as to
                    said   officers   and   directors.   Exhibit   B  is  herein
                    incorporated by reference.

         /2/        Please see attached Exhibit C indicating the general partner
                    of  Aries  Domestic  and  the  general  partner's  executive
                    officers and directors and providing  information called for
                    by Items 2-6 of this statement as to said general  partners,
                    officers and directors.  Exhibit C is herein incorporated by
                    reference.

         /3/        Please see  attached  Exhibit D  indicating  the  investment
                    manager  of the  Aries  Trust and the  investment  manager's
                    executive officers and direc tors and providing  information
                    called  for  by  Items  2-6 of  this  statement  as to  said
                    investment manager and officers and directors.  Exhibit D is
                    herein incorporated by reference.


                                        6

<PAGE>


               Federal or State securities laws or finding any violation with 
               respect to such laws.

        (f)    Dr. Rosenwald is a citizen of the United States.

Item 3. Source and Amount of Funds or Other Consideration.

               Since  October 10, 1997,  the date of Amendment No. 4 ("Amendment
               No. 3") to the original  statement on Schedule 13D (the "Original
               Statement"),  the Aries  Domestic  used its general funds to make
               certain open market  acquisitions of the securities of the Issuer
               and the Aries Trust used its general  funds to make  certain open
               market acquisitions of the securities of the Issuer as more fully
               set forth in Item 5.

Item 4. Purpose of Transaction.

               The  Reporting  Parties  acquired  shares  of  Common  Stock  and
               Warrants of the Issuer as an investment in the Issuer.

               Although the Reporting Parties have not formulated any definitive
               plans, they may from time to time acquire,  or dispose of, Common
               Stock and/or other securities of the Issuer if and when they deem
               it  appropriate.   The  Reporting  Parties  may  formulate  other
               purposes,  plans or proposals  relating to any of such securities
               of the Issuer to the extent  deemed  advisable in light of market
               conditions, investment policies and other factors.

               Except as indicated in this Schedule  13D, the Reporting  Parties
               currently  have no plans or  proposals  that  relate  to or would
               result  in any of the  matters  described  in  subparagraphs  (a)
               through (j) of Item 4 of Schedule 13D.

Item 5. Interest in Securities of the Issuer.

               (a)    As of  January  30,  1998,  Dr.  Rosenwald  and  Paramount
                      Capital,  through  acquisi tion of the shares by the Aries
                      Trust and Aries  Domestic,  beneficially  owned  5,165,468
                      shares  or  14.8% of the  Issuer's  securities  and  Aries
                      Domestic  and  the  Aries  Trust   beneficially  owned  as
                      follows:

                                                   Amount Owned
                                                   ------------
                      Aries Domestic               1,615,317 Shares
                      Aries Trust                  3,550,151 Shares

               (b)    Dr.  Rosenwald  and  Paramount  Capital share the power to
                      vote or to direct  the vote,  to  dispose or to direct the
                      disposition  of  those  shares  owned  by  each  of  Aries
                      Domestic and Aries Trust.

               (c)    The following purchases were made by Aries Domestic in the
                      open market in the sixty days prior to January 30, 1998:

                      Date                         Amount        Price
                      ----                         ------        -----
                      12/12/97                      2,900        1.313
                      12/15/97                      9,000        1.313
                      12/16/97                      7,600        1.281
                      12/17/97                      3,300        1.375
                      12/18/97                      4,000        1.375
                      12/19/97                      8,500        1.281
                      12/22/97                      8,500        1.281
                      12/23/97                     20,400        1.211
                      12/26/97                      3,400        1.188
                      12/31/97                      3,400        1.250
                      01/02/98                      5,100        1.375


                                        7

<PAGE>



                      01/05/98                      3,400        1.438
                      01/26/98                     16,500        3.500
                      01/27/98                     16,500        3.163
                      01/28/98                      1,000        2.625
                      01/28/98                     28,300        2.776

                      The  following  purchases  were made by Aries Trust in the
                      open market in the sixty days prior to January 30, 1998:

                      Date                         Amount        Price
                      ----                         ------        -----
                      12/12/97                      5,600        1.313
                      12/15/97                     17,500        1.313
                      12/16/97                     14,900        1.281
                      12/17/97                      6,700        1.375
                      12/18/97                      8,500        1.375
                      12/19/97                     16,500        1.281
                      12/22/97                     16,500        1.281
                      12/23/97                     39,600        1.211
                      12/26/97                      6,600        1.188
                      12/31/97                      6,600        1.250
                      01/02/98                      9,900        1.375
                      01/05/98                      6,600        1.438
                      01/26/98                     33,500        3.500
                      01/27/98                     33,500        3.163
                      01/28/98                      2,000        2.625
                      01/28/98                     56,700        2.776

               Other than as set forth  herein the  Reporting  Parties  have not
               engaged in any  transactions  in the  Common  Stock of the Issuer
               since the last filing.

               (d) & (e)     Not applicable.


Item 6. Contracts, Arrangements, Understandings or Relationships
        with respect to Securities of the Issuer

               Paramount  Capital is the  investment  manager of the Aries Trust
               and the General  Partner of Aries Domestic and in such capacities
               has the authority to make certain investment  decisions on behalf
               of such entities,  including decisions relating to the securities
               of the  Issuer.  In  connection  with its  investment  management
               duties,  Paramount  Capital receives certain  management fees and
               performance  allocations from the Aries Trust and Aries Domestic.
               Dr.  Rosenwald  is the sole  shareholder  of  Paramount  Capital.
               Except  as  indicated  in this  13D  and  exhibits,  there  is no
               contract, arrangement,  understanding or relationship between the
               Reporting  Parties  and any other  person,  with  respect  to any
               securities of the Issuer.

Item 7. Material to be Filed as Exhibits:

Exhibit A  -   Copy  of  an  Agreement  between  Dr.  Rosenwald,  Paramount
               Capital, Aries Domestic and Aries Trust to file this Statement on
               Schedule 13D on behalf of each of them.

Exhibit B  -   List of executive officers and directors of Paramount Capital
               and  information  called  for  by  Items  2-6 of  this  statement
               relating to said officers and directors.

Exhibit C  -   List of executive  officers and  directors of Aries  Domestic
               and  information  called  for  by  Items  2-6 of  this  statement
               relating to said officers and directors.

Exhibit  D  -  List of executive  officers and  directors of Aries Trust and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.


                                        8

<PAGE>


                                   SIGNATURES


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  January 30, 1998
        New York, NY                 By /s/ Lindsay A. Rosenwald, M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President


                                     ARIES DOMESTIC FUND,  L.P.
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:  January 30, 1998
        New York, NY                  By /s/ Lindsay A. Rosenwald, M.D.
                                         ------------------------------
                                         Lindsay A. Rosenwald, M.D.
                                         President


                                     THE ARIES TRUST
                                     By Paramount Capital Asset Management, Inc.
                                     Investment Manager

Dated:  January 30, 1998
        New York, NY                  By /s/ Lindsay A. Rosenwald, M.D.
                                         ------------------------------
                                         Lindsay A. Rosenwald, M.D.
                                         President


Dated:  January 30, 1998
        New York, NY                  By  /s/ Lindsay A. Rosenwald, M.D.
                                          ------------------------------
                                          Lindsay A. Rosenwald, M.D.



                                        9

<PAGE>


                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D


         The  undersigned  hereby  agrees  to  jointly  prepare  and  file  with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each  of  the  undersigned's   ownership  of  securities  of  Cypress
Bioscience,  Inc.,  and hereby  affirm that such  Schedule 13D is being filed on
behalf of each of the undersigned.

                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  January 30, 1998
        New York, NY                 By /s/ Lindsay A. Rosenwald, M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President


                                     ARIES DOMESTIC FUND, L.P.
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:  January 30, 1998
        New York, NY                  By /s/ Lindsay A. Rosenwald, M.D.
                                         ------------------------------
                                         Lindsay A. Rosenwald, M.D.
                                         President


                                     THE ARIES TRUST
                                     By Paramount Capital Asset Management, Inc.
                                     Investment Manager

Dated:  January 30, 1998
        New York, NY                  By /s/ Lindsay A. Rosenwald, M.D.
                                         ------------------------------
                                         Lindsay A. Rosenwald, M.D.
                                         President


Dated:  January 30, 1998
        New York, NY                  By  /s/ Lindsay A. Rosenwald, M.D.
                                          ------------------------------
                                          Lindsay A. Rosenwald, M.D.


                                       10

<PAGE>


                                    EXHIBIT B

        The name and principal occupation or employment,  which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                                   PRINCIPAL OCCUPATION
        NAME                                          OR EMPLOYMENT

Lindsay A. Rosenwald, M.D.         Chairman of the Board, President of Paramount
                                   Capital Asset Management, Inc., Paramount
                                   Capital Investments, LLC and Paramount
                                   Capital, Inc.

Peter Morgan Kash                  Director of Paramount Capital Asset
                                   Management, Inc., Senior Managing Director,
                                   Paramount Capital, Inc.

Dr. Yuichi Iwaki                   Director of Paramount Capital Asset
                                   Management, Inc., Professor, University of
                                   Southern California School of Medicine


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.







                                       11

<PAGE>

                                    EXHIBIT C

         The name and principal  occupation or  employment,  which is located at
787  Seventh  Avenue,  48th Floor,  New York,  New York,  10019,  of the General
Partner of Aries Domestic is as follows:

                                                      PRINCIPAL OCCUPATION
        NAME                                             OR EMPLOYMENT

Paramount Capital Asset Management, Inc      General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.




                                       12

<PAGE>


                                    EXHIBIT D

         The name and principal occupation or employment, which in each instance
is with The Aries Trust  ("Aries  Trust")  located at 787 Seventh  Avenue,  48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                    PRINCIPAL OCCUPATION
        NAME                                           OR EMPLOYMENT

Paramount Capital Asset Management, Inc.            Investment Manager

MeesPierson (Cayman) Limited                        Trustee

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years  prior to the date  hereof,  neither of the above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.





                                       13



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