CYPRESS BIOSCIENCE INC
SC 13G, 1998-05-26
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                    -----------------------------------------


                                  SCHEDULE 13G
                    Under the Securities Exchange Act of 1934
                    -----------------------------------------


                            Cypress Biosciences, Inc.
                    -----------------------------------------
                                (Name of Issuer)


                     Common Stock, par value $0.02 per share
                   ------------------------------------------
                         (Title of Class of Securities)

                                  2 232674 101
                                  -------------
                                 (CUSIP Number)

                                 April 28, 1998
                                -----------------
             (Date of Event Which Requires Filing of the Statement)

     Check the  appropriate  box to  designate  the rule  pursuant to which this
     Schedule is filed:

                  [ ] Rule 13d-1(b)
                  [X] Rule 13d-1(c)
                  [ ] Rule 13d-1(d)


        *The  remainder  of this cover page shall be filled out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

        The  information  required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes to Schedule 13G).

                                        1

<PAGE>


                                  SCHEDULE 13G
CUSIP No. 2 232674 101                                        Page  of   Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    
    Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          6,049,928
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        6,049,928
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         6,049,928
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         15.55%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         CO
- --------------------------------------------------------------------------------


                                        2

<PAGE>

                                  SCHEDULE 13G
CUSIP No. 2 232674 101                                        Page   of    Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    
    Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          1,894,367
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        1,894,367
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         1,894,367
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         4.88%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------

                                        3

<PAGE>

                                  SCHEDULE 13G
CUSIP No. 2 232674 101                                        Page   of    Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    
    The Aries Trust
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION

    Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          4,155,561
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        4,155,561
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         4,155,561
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         10.69%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         OO (see Item 2)
- --------------------------------------------------------------------------------

                                       4
<PAGE>

                                  SCHEDULE 13G
CUSIP No. 2 232674 101                                        Page   of    Pages
- --------------------------------------------------------------------------------
1)  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    
    Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)   [_]
                                                     (b)   [_]
- --------------------------------------------------------------------------------
3)  SEC USE ONLY

- --------------------------------------------------------------------------------
4)  SOURCE OF FUNDS*
    OO (see Item 3 below)
- --------------------------------------------------------------------------------
5)  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                [_]
- --------------------------------------------------------------------------------
6)  CITIZENSHIP OR PLACE OF ORGANIZATION

    United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                    
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          6,049,928
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                        6,049,928
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         6,049,928
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         15.55%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------

                                        5

<PAGE>

Item 1.

          (a)  Name of Issuer:

               Cypress Bioscience, Inc. (the "Company")

          (b)  Address of Issuer's Principal Executive Offices:

               Cypress Bioscience, Inc.
               4350 Executive Drive, Suite 325
               San Diego, CA 92121
               (619) 452-2323

Item 2.

          (a)  Name of Person Filing:

               This  statement  is filed on behalf of  Paramount  Capital  Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
               ("Aries  Domestic"),  The Aries Trust ("Aries Trust") and Lindsay
               A. Rosenwald, M.D. ("Dr. Rosenwald" and collectively,  "Reporting
               Parties").  See  attached  Exhibit  A,  which  is a copy of their
               agreement in writing to file this  statement on behalf of each of
               them.

               Dr. Rosenwald is an investment banker,  venture capitalist,  fund
               manager and sole shareholder of Paramount Capital, a Subchapter S
               corporation  incorporated in Delaware.  Paramount  Capital is the
               General  Partner  of  Aries  Domestic,   a  limited   partnership
               incorporated  in Delaware.  Paramount  Capital is the  Investment
               Manager to Aries Trust, a Cayman Islands Trust.

          (b)  Address of Principal Business Office or, if None, Residence:

               Paramount   Capital's,   Aries  Domestic's  and  Dr.  Rosenwald's
               business address is 787 Seventh Avenue, 48th Floor, New York, New
               York,  10019.  The  business  address  for  Aries  Trust  is  c/o
               MeesPierson  (Cayman)  Limited,  P.O. Box 2003,  British American
               Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

          (c)  Citizen:

               Dr. Rosenwald is a citizen of the United States.

          (d)  Title of Class of Securities:

               Common Stock, $0.02 par value ("shares").

          (e)  CUSIP#:

               2 232674 101

Item 3.        Check  the  box if  this  statement  is  filed  pursuant  to Rule
               13d-1(c)[X]

                                        6

<PAGE>

Item 4.        Ownership:

               For  information  concerning the ownership of Common Stock
               of the  Company  by the  Reporting  Persons,  see  Items 5
               through 9 and 11 of the cover pages to this  schedule  13G
               and footnotes thereto.

Item 5.        Ownership of Five Percent or Less of a Class:

               Not applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person:

               Not applicable.

Item 7.        Identification   and   Classification  of  the  Subsidiary  Which
               Acquired the  Security  Being  Reported On By the Parent  Holding
               Company:

               Not applicable.

Item 8.        Identification and Classification of Members of the Group:

               Not applicable.

Item 9.        Notice of Dissolution of Group:

               Not applicable.

Item 10.       Certification:

               Material to be Filed as Exhibits:


Exhibit A - Copy  of  an  Agreement  between  Dr.  Rosenwald,  Paramount
            Capital, Aries Domestic and Aries Trust to file this Statement on
            Schedule 13G on behalf of each of them.

Exhibit B - List of executive officers and directors of Paramount Capital
            and  information  called  for  by  Items  2-6 of  this  statement
            relating to said officers and directors.

Exhibit C - List of executive  officers and  directors of Aries  Domestic
            and  information  called  for  by  Items  2-6 of  this  statement
            relating to said officers and directors.

Exhibit D - List of executive  officers and  directors of Aries Trust and
            information called for by Items 2-6 of this statement relating to
            said officers and directors.

                      By  signing  below  I  certify  that,  to the  best  of my
        knowledge and belief, the securities referred to above were not acquired
        and are not held for the  purpose of or with the effect of  changing  or
        influencing  the  control of the issuer of the  securities  and were not
        acquired and are not held in connection  with or as a participant in any
        transaction having that purpose or effect.

                                        7

<PAGE>

                                   SIGNATURES


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  May 18, 1998
        New York, NY                 By /s/ Lindsay A. Rosenwald, M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President


                                     ARIES DOMESTIC FUND,  L.P.
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:  May 18, 1998
        New York, NY                  By /s/ Lindsay A. Rosenwald, M.D.
                                         ------------------------------
                                         Lindsay A. Rosenwald, M.D.
                                         President


                                     THE ARIES TRUST
                                     By Paramount Capital Asset Management, Inc.
                                     Investment Manager

Dated:  May 18, 1998
        New York, NY                  By /s/ Lindsay A. Rosenwald, M.D.
                                         ------------------------------
                                         Lindsay A. Rosenwald, M.D.
                                         President


Dated:  May 18, 1998
        New York, NY                  By  /s/ Lindsay A. Rosenwald, M.D.
                                          ------------------------------
                                          Lindsay A. Rosenwald, M.D.

                                        8

<PAGE>


                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13G


         The  undersigned  hereby  agrees  to  jointly  prepare  and  file  with
regulatory  authorities  a  Schedule  13G  and  any  future  amendments  thereto
reporting  each  of  the  undersigned's   ownership  of  securities  of  Cypress
Bioscience,  Inc.,  and hereby  affirm that such  Schedule 13G is being filed on
behalf of each of the undersigned.

                                     PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  May 18, 1998
        New York, NY                 By /s/ Lindsay A. Rosenwald, M.D.
                                        ------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President


                                     ARIES DOMESTIC FUND, L.P.
                                     By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:  May 18, 1998
        New York, NY                  By /s/ Lindsay A. Rosenwald, M.D.
                                         ------------------------------
                                         Lindsay A. Rosenwald, M.D.
                                         President


                                     THE ARIES TRUST
                                     By Paramount Capital Asset Management, Inc.
                                     Investment Manager

Dated:  May 18, 1998
        New York, NY                  By /s/ Lindsay A. Rosenwald, M.D.
                                         ------------------------------
                                         Lindsay A. Rosenwald, M.D.
                                         President


Dated:  May 18, 1998
        New York, NY                  By  /s/ Lindsay A. Rosenwald, M.D.
                                          ------------------------------
                                          Lindsay A. Rosenwald, M.D.


                                        9

<PAGE>


                                    EXHIBIT B

        The name and principal occupation or employment,  which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                                   PRINCIPAL OCCUPATION
        NAME                                          OR EMPLOYMENT

Lindsay A. Rosenwald, M.D.         Chairman of the Board, President of Paramount
                                   Capital Asset Management, Inc., Paramount
                                   Capital Investments, LLC and Paramount
                                   Capital, Inc.

Peter Morgan Kash                  Director of Paramount Capital Asset
                                   Management, Inc., Senior Managing Director,
                                   Paramount Capital, Inc.

Dr. Yuichi Iwaki                   Director of Paramount Capital Asset
                                   Management, Inc., Professor, University of
                                   Southern California School of Medicine


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       10
<PAGE>


                                    EXHIBIT C

         The name and principal  occupation or  employment,  which is located at
787  Seventh  Avenue,  48th Floor,  New York,  New York,  10019,  of the General
Partner of Aries Domestic is as follows:

                                                      PRINCIPAL OCCUPATION
        NAME                                             OR EMPLOYMENT

Paramount Capital Asset Management, Inc      General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.

                                       11

<PAGE>




                                    EXHIBIT D

        The name and principal  occupation or  employment,  which in the case of
Paramount Capital Asset Management,  Inc. is located at 787 Seventh Avenue, 48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                         PRINCIPAL OCCUPATION
        NAME                                                OR EMPLOYMENT

Paramount Capital Asset Management, Inc.                  Investment Manager

MeesPierson (Cayman) Limited                              Trustee
P.O. Box 2003
British American Centre
Phase 3, Dr. Roy's Drive
George Town, Grand Cayman

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five  years  prior to the date  hereof,  neither of the above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.

                                       12



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