CYPRESS BIOSCIENCE INC
SC 13D/A, 1999-01-11
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                        SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C.  20549

                                   SCHEDULE 13D
                                 (Amendment No.1)

                     Under the Securities Exchange Act of 1934


                             Cypress Bioscience, Inc.    
                        ---------------------------------
                                 (Name of Issuer)


                      Common Stock, par value $.02 per share
                      --------------------------------------
                          (Title of Class of Securities)

                                   2 232674 101            
                          ----------------------------
                                  (CUSIP Number)


                     Paramount Capital Asset Management, Inc.
                          c/o Lindsay A. Rosenwald, M.D.
                                787 Seventh Avenue
                                New York, NY 10019
                                  (212) 554-4300
                                  with a copy to:

                                 Michael S. Weiss
                     Paramount Capital Asset Management, Inc.
                                787 Seventh Avenue
                                New York, NY 10019
                                  (212) 554-4372
                               -------------------

      (Name, Address and Telephone Number of Person Authorized to Receive
                          Notices and Communications)


                                December 30, 1998         
                          -----------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:
                                                            [ ] 

Check the following box if a fee is being paid with this Statement:

                                                            [ ] 


<PAGE>


- ----------------------                                   
CUSIP No. 2 232674 101             13D                   
- ----------------------                                   

- --------------------------------------------------------------------------------

1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS*
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                      [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8       SHARED VOTING POWER
             OWNED BY                       8,661,635
                                    --------------------------------------------
               EACH                 9       SOLE DISPOSITIVE POWER
             REPORTING                      None
                                    --------------------------------------------
              PERSON                10      SHARED DISPOSITIVE POWER
               WITH                         8,661,635 
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         8,661,635

- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         21.3%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*
         CO

- --------------------------------------------------------------------------------



                                       2

<PAGE>

- ----------------------                                   
CUSIP No. 2 232674 101             13D                   
- ----------------------                                   

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS* 
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      2,548,400
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        2,548,400
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,548,400
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         6.4%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------



                                       3



<PAGE>

- ----------------------                                   
CUSIP No. 2 232674 101             13D                   
- ----------------------                                   

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        The Aries Master Fund
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS* 
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Cayman Islands
- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      6,063,235
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        6,063,235
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         6,063,235
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         15.0%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON* 
         OO (see Item 2)
- --------------------------------------------------------------------------------


                                       4
<PAGE>

- ----------------------                                   
CUSIP No. 2 232674 101             13D                   
- ----------------------                                   

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS* 
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      8,661,635
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        8,661,635
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         8,661,635
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         21.3%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON* 
         IN
- --------------------------------------------------------------------------------


                                       5
<PAGE>

Item 1.        Security and Issuer.
               -------------------

        (a)    Common Stock, $.001 par value ("Shares")

               Cypress Bioscience, Inc. (the "Issuer")
               4350 Executive Drive, Suite 325
               San Diego, CA 92121
               (619) 452-2323

Item 2.        Identity and Background.
               -----------------------

        Names of Persons Filing:

        (a)    This  statement  is filed on behalf of  Paramount  Capital  Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
               ("Aries  Domestic"),  Aries Master Fund, a Cayman Island exempted
               company  ("Aries  Fund") and  Lindsay A.  Rosenwald,  M.D.  ("Dr.
               Rosenwald" and collectively,  "Reporting Parties").  See attached
               Exhibit A which is a copy of their  agreement  in writing to file
               this statement on behalf of each of them.

        (b)    Paramount   Capital's,   Aries  Domestic's  and  Dr.  Rosenwald's
               business address is 787 Seventh Avenue, 48th Floor, New York, New
               York,   10019.  The  business  address  for  Aries  Fund  is  c/o
               MeesPierson  (Cayman)  Limited,  P.O. Box 2003,  British American
               Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

        (c)    Dr. Rosenwald is an investment banker,  venture capitalist,  fund
               manager  and  sole  shareholder  of  Paramount  Capital,   /1/  a
               Subchapter S  corporation  incorporated  in  Delaware.  Paramount
               Capital is the General Partner of Aries  Domestic,  /2/ a limited
               partnership  incorporated in Delaware.  Paramount  Capital is the
               Investment  Manager to Aries Fund, /3/ a Cayman Islands  exempted
               company.

        (d)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Fund
               and their  respec tive  officers,  directors,  general  partners,
               investment managers,  or trustees have not, during the five years
               prior to the date hereof, been convicted in a criminal proceeding
               (excluding traffic violations or similar misdemeanors).

        (e)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Fund
               and  their  respective  officers,  directors,  general  partners,
               investment  managers,  or trustees have not been, during the five
               years prior to the date hereof,  parties to a civil proceeding of
               a judicial or administrative body of competent jurisdiction, as a
               result of which such  person  was or is  subject  to a  judgment,
               decree  or  final  order  enjoining  future   violations  of,  or
               prohibiting or mandating  activities subject to, Federal or State
               securities  laws or finding any  violation  with  respect to such
               laws.

        (f)    Dr. Rosenwald is a citizen of the United States.


- ------------------------
               1    Please  see  attached  Exhibit B  indicating  the  executive
                    officers and  directors of Paramount  Capital and  providing
                    information  called for by Items 2-6 of this statement as to
                    said   officers   and   directors.   Exhibit   B  is  herein
                    incorporated by reference.

               2    Please see attached Exhibit C indicating the general partner
                    of  Aries  Domestic  and  the  general  partner's  executive
                    officers and directors and providing  information called for
                    by Items 2-6 of this statement as to said general  partners,
                    officers and directors.  Exhibit C is herein incorporated by
                    reference.  

               3    Please see  attached  Exhibit D  indicating  the  investment
                    manager  of the  Aries  Fund  and the  investment  manager's
                    executive  officers and directors and providing  information
                    called  for  by  Items  2-6 of  this  statement  as to  said
                    investment manager and officers and directors.  Exhibit D is
                    herein incorporated by reference.



                                       6

<PAGE>

Item 3.        Source and Amount of Funds or Other Consideration.
               -------------------------------------------------

               Since October 30, 1998,  the date on which the Reporting  Parties
               were  required to file on Schedule  13D in lieu of Schedule  13G,
               Aries Domestic used its general funds to make certain open market
               acquisitions  of the  securities of the Issuer and the Aries Fund
               used its general  funds to make certain open market  acquisitions
               of the  securities  of the Issuer as more fully set forth in Item
               5.

Item 4.        Purpose of Transaction.
               ----------------------

               The  Reporting  Parties  acquired  shares of Common  Stock of the
               Issuer as an investment in the Issuer.

               Although the Reporting Parties have not formulated any definitive
               plans, they may from time to time acquire,  or dispose of, Common
               Stock and/or other securities of the Issuer if and when they deem
               it  appropriate.   The  Reporting  Parties  may  formulate  other
               purposes,  plans or proposals  relating to any of such securities
               of the Issuer to the extent  deemed  advisable in light of market
               conditions, investment policies and other factors.

               Except as indicated in this Schedule  13D, the Reporting  Parties
               currently  have no plans or  proposals  that  relate  to or would
               result  in any of the  matters  described  in  subparagraphs  (a)
               through (j) of Item 4 of Schedule 13D.

Item 5.        Interest in Securities of the Issuer.
               ------------------------------------

               (a)    As  of  January  8,  1999,  Dr.  Rosenwald  and  Paramount
                      Capital,  through  acquisition of the shares by the Aries
                      Fund and  Aries  Domestic,  beneficially  owned  8,661,635
                      shares  or  21.3% of the  Issuer's  securities  and  Aries
                      Domestic and the Aries Fund beneficially owned as follows:

                                                   Amount Owned
                                                   ------------
                      Aries Domestic               2,540,000 Shares
                      Aries Fund                   6,063,235 Shares

               (b)    Dr.  Rosenwald  and  Paramount  Capital share the power to
                      vote or to direct  the vote,  to  dispose or to direct the
                      disposition  of  those  shares  owned  by  each  of  Aries
                      Domestic and Aries Fund.

               (c)    The following purchases were made by Aries Domestic in the
                      open market in the sixty days prior to this filing:

                      Date                         Amount        Price
                      ----                         ------       -------
                      10/30/98                     10,400       $3.029
                      10/30/98                     18,200        3.086
                      11/03/98                      3,900        2.896
                      11/04/98                      1,300        2.875
                      11/05/98                      5,200        2.818
                      11/06/98                      9,100        2.818
                      11/06/98                      3,500        2.750
                      11/09/98                      2,600        2.656
                      11/24/98                      2,600        2.799
                      11/24/98                      2,600        2.834
                      11/25/98                      2,600        2.688



                                       7

<PAGE>

                      11/25/98                      2,600        2.750
                      11/27/98                      2,600        2.750
                      11/30/98                      2,600        2.738
                      11/30/98                      2,600        2.719
                      11/30/98                      7,800        2.716
                      11/30/98                      2,600        2.688
                      12/01/98                      1,300        2.688
                      12/02/98                      2,600        2.944
                      12/03/98                      1,300        2.906
                      12/03/98                      1,300        2.969
                      12/03/98                      2,300        3.000
                      12/03/98                        300        2.969
                      12/04/98                      5,200        2.923
                      12/04/98                      1,300        2.938
                      12/07/98                      1,300        2.969
                      12/07/98                      9,700        2.883
                      12/08/98                      2,600        2.847
                      12/08/98                        500        2.750
                      12/09/98                      1,000        2.875
                      12/10/98                      3,700        2.938
                      12/10/98                      2,600        2.927
                      12/11/98                      2,600        3.063
                      12/11/98                      2,600        3.019
                      12/14/98                      2,600        3.044
                      12/14/98                      2,600        3.063
                      12/15/98                      2,600        3.042
                      12/16/98                      1,300        2.938
                      12/16/98                      2,600        2.979
                      12/16/98                      2,600        2.979
                      12/17/98                      3,900        2.993
                      12/17/98                      1,300        3.000
                      12/18/98                      3,900        2.986
                      12/18/98                      1,300        3.000
                      12/21/98                      1,300        3.000
                      12/21/98                      1,300        2.969
                      12/22/98                      2,600        2.930
                      12/22/98                      1,300        2.938
                      12/24/98                      1,300        3.000
                      12/28/98                     10,400        2.915
                      12/29/98                      2,600        2.923
                      12/30/98                      3,900        2.914
                      12/30/98                      1,300        2.938
                      12/31/98                      7,800        3.013
                      12/31/98                      1,300        3.000
                      01/04/99                      1,300        2.986
                      01/05/99                      1,300        2.890
                      01/06/99                      2,600        2.812
                      01/07/99                      2,600        2.825

                      The  following  purchases  were made by Aries  Fund in the
                      open  market in the sixty  days  prior to the date of this
                      filing:

                      Date                         Amount        Price
                      ----                         ------        -----
                      10/30/98                     29,600        3.029
                      10/30/98                     51,800        3.086
                      11/03/98                     11,100        2.896
                      11/04/98                      3,700        2.875
                      11/05/98                     14,800        2.818
                      11/06/98                     25,900        2.818
                      11/06/98                     10,000        2.750
                      11/09/98                      7,400        2.656
                      11/24/98                      7,400        2.799
                      11/24/98                      7,400        2.834
                      11/25/98                      7,400        2.688
                      11/25/98                      7,400        2.750
                      11/27/98                      7,400        2.750
                      11/30/98                      7,400        2.738
                      11/30/98                      7,400        2.719
                      11/30/98                     22,200        2.716
                      11/30/98                      7,400        2.688
                      12/01/98                      3,700        2.688
                      12/02/98                      7,400        2.944
                      12/03/98                      3,700        2.906
                      12/03/98                      3,700        2.969
                      12/03/98                      6,700        3.000
                      12/03/98                        700        2.969
                      12/04/98                     14,800        2.923
                      12/04/98                      3,700        2.938
                      12/07/98                      3,700        2.969
                      12/07/98                     27,800        2.883
                      12/08/98                      1,500        2.847
                      12/08/98                      7,400        2.750



                                       8

<PAGE>

                      12/09/98                     10,800        2.875
                      12/10/98                      7,400        2.938
                      12/10/98                      7,400        2.927
                      12/11/98                      7,400        3.063
                      12/11/98                      7,400        3.019
                      12/14/98                      7,400        3.044
                      12/14/98                      7,400        3.063
                      12/15/98                      7,400        3.042
                      12/16/98                      3,700        2.938
                      12/16/98                      7,400        2.979
                      12/16/98                      7,400        2.979
                      12/17/98                      3,700        2.993
                      12/17/98                     11,100        3.000
                      12/18/98                      3,700        2.986
                      12/18/98                     11,100        3.000
                      12/21/98                      3,700        3.000
                      12/21/98                      3,700        2.969
                      12/22/98                      3,700        2.930
                      12/22/98                      7,400        2.938
                      12/24/98                      3,700        3.000
                      12/28/98                     29,600        2.915
                      12/29/98                      7,400        2.923
                      12/30/98                     11,100        2.914
                      12/30/98                      3,700        2.938
                      12/31/98                      3,700        3.000
                      12/31/98                     22,200        3.013
                      01/04/99                      1,300        2.986
                      01/05/99                      1,300        2.890
                      01/06/99                      2,600        2.812
                      01/07/99                      2,600        2.825

               Other than as set forth  herein the  Reporting  Parties  have not
               engaged in any  transactions  in the  Common  Stock of the Issuer
               since the last filing.

               (d) & (e)     Not applicable.

Item 6.        Contracts, Arrangements, Understandings or Relationships
               with respect to Securities of the Issuer
               --------------------------------------------------------

               Paramount Capital is the investment manager of the Aries Fund and
               the General  Partner of Aries Domestic and in such capacities has
               the authority to make certain  investment  decisions on behalf of
               such entities,  including decisions relating to the securities of
               the Issuer. In connection with its investment  management duties,
               Paramount   Capital   receives   certain   management   fees  and
               performance  allocations  from the Aries Fund and Aries Domestic.
               Dr.  Rosenwald  is the sole  shareholder  of  Paramount  Capital.
               Except  as  indicated  in this  13D  and  exhibits,  there  is no
               contract, arrangement,  understanding or relationship between the
               Reporting  Parties  and any other  person,  with  respect  to any
               securities of the Issuer.

Item 7.        Material to be Filed as Exhibits:
               --------------------------------

Exhibit A -    Copy  of  an  Agreement  between  Dr.  Rosenwald,  Paramount
               Capital,  Aries Domestic and Aries Fund to file this Statement on
               Schedule 13D on behalf of each of them.


Exhibit B -    List of executive officers and directors of Paramount Capital
               and  information  called  for  by  Items  2-6 of  this  statement
               relating to said officers and direc tors.

Exhibit C -    List of executive  officers and  directors of Aries  Domestic
               and  information  called  for  by  Items  2-6 of  this  statement
               relating to said officers and direc tors.

Exhibit D -    List of executive  officers  and  directors of Aries Fund and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.



                                        9

<PAGE>

                                   SIGNATURES
                                   ----------


               After  reasonable  inquiry  and to the best of my  knowledge  and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


                                 PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  January 11, 1999
        New York, NY             By /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman


                                 ARIES DOMESTIC FUND
                                 By  Paramount Capital Asset Management, Inc.
                                      General Partner

Dated:  January 11, 1999
        New York, NY             By /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman


                                 THE ARIES MASTER FUND
                                 By Paramount Capital Asset Management, Inc.
                                 Investment Manager

Dated:  January 11, 1999
        New York, NY             By /s/ Lindsay A. Rosenwald, M.D. 
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman


Dated:  January 11, 1999
        New York, NY            By  /s/ Lindsay A. Rosenwald, M.D.  
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.



                                       11


<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D



               The  undersigned  hereby agrees to jointly  prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each  of the  undersig  ned's  ownership  of  securities  of  Cypress
Bioscience,  Inc.,  and hereby  affirm that such  Schedule 13D is being filed on
behalf of each of the undersigned.


                                PARAMOUNT CAPITAL ASSET MANAGEMENT, INC., INC.

Dated:  January 11, 1999
        New York, NY            By /s/ Lindsay A. Rosenwald. M.D.   
                                   -------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                ARIES DOMESTIC FUND, L.P.
                                By Paramount Capital Asset Management, Inc.
                                General Partner

Dated:  January 11, 1999
        New York, NY            By /s/ Lindsay A. Rosenwald   M.D.
                                   -------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                THE ARIES MASTER FUND
                                By Paramount Capital Asset Management, Inc.
                                Investment Manager

Dated:  January 11, 1999
        New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                   -------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman

Dated:  January 11, 1999
        New York, NY            By  /s/ Lindsay A. Rosenwald, M.D.   
                                   -------------------------------
                                    Lindsay A. Rosenwald, M.D.



                                       12

<PAGE>

                                    EXHIBIT B

        The name and principal occupation or employment,  which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

<TABLE>
<CAPTION>

                                                                 PRINCIPAL OCCUPATION
        NAME                                                        OR EMPLOYMENT
        ----                                                        -------------
<S>                                          <C>    


Lindsay A. Rosenwald, M.D.                         Chairman of the Board of Paramount Capital
                                                   Asset Management, Inc., Paramount Capital
                                                   Investments, LLC and Paramount Capital, Inc.

Mark C. Rogers, M.D.                               President of Paramount Capital Asset
                                                   Management, Inc., Paramount Capital
                                                   Investments, LLC and Paramount Capital, Inc.

Peter Morgan Kash                                  Director of Paramount Capital Asset
                                                   Management, Inc., Senior Managing Director,
                                                   Paramount Capital, Inc.

Dr. Yuichi Iwaki                                   Director of Paramount Capital Asset
                                                   Management, Inc., Professor, University of
                                                   Southern California School of Medicine

</TABLE>

Item 2.

        During  the  five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.



                                       13

<PAGE>

                                    EXHIBIT C

        The name and principal occupation or employment, which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic is as follows:

<TABLE>
<CAPTION>

                                                                 PRINCIPAL OCCUPATION
        NAME                                                        OR EMPLOYMENT
        ----                                                        -------------
<S>                                               <C>    

Paramount Capital Asset Management, Inc.                  General Partner; Investment Manager

</TABLE>

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five years prior to the date hereof, the above person (to the
best of  Aries  Domestic's  knowledge)  has not  been  convicted  in a  criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.



                                       14

<PAGE>

                                    EXHIBIT D

        The name and principal occupation or employment,  which in each instance
is with The Aries Master Fund ("Aries Fund") located at 787 Seventh Avenue, 48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:


                                                   PRINCIPAL OCCUPATION
        NAME                                          OR EMPLOYMENT
        ----                                          -------------

Paramount Capital Asset Management, Inc.           Investment Manager

MeesPierson (Cayman) Limited                       Administrator

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five  years  prior to the date  hereof,  neither of the above
persons  (to the  best of Aries  Fund's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.



                                       15


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