CYPRESS BIOSCIENCE INC
SC 13D/A, 1999-06-21
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                        SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C.  20549

                                   SCHEDULE 13D
                                 (Amendment No.3)

                     Under the Securities Exchange Act of 1934


                             Cypress Bioscience, Inc.
                        ---------------------------------
                                 (Name of Issuer)


                      Common Stock, par value $.02 per share
                      --------------------------------------
                          (Title of Class of Securities)

                                   2 232674 101
                          ----------------------------
                                  (CUSIP Number)


                     Paramount Capital Asset Management, Inc.
                          c/o Lindsay A. Rosenwald, M.D.
                                787 Seventh Avenue
                                New York, NY 10019
                                  (212) 554-4300
                                  with a copy to:

                                 Michael S. Weiss
                     Paramount Capital Asset Management, Inc.
                                787 Seventh Avenue
                                New York, NY 10019
                                  (212) 554-4372
                               -------------------

      (Name, Address and Telephone Number of Person Authorized to Receive
                          Notices and Communications)


                                April 15, 1999
                          -----------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following:[ ]

<PAGE>


- ----------------------
CUSIP No. 2 232674 101             13D
- ----------------------

- --------------------------------------------------------------------------------

1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS*
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                      [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8       SHARED VOTING POWER
             OWNED BY                       11,994,002 /1/
                                    --------------------------------------------
               EACH                 9       SOLE DISPOSITIVE POWER
             REPORTING                      None
                                    --------------------------------------------
              PERSON                10      SHARED DISPOSITIVE POWER
               WITH                         11,994,002 /1/
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         11,994,002 /1/

- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         26.2%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*
         CO

- --------------------------------------------------------------------------------


- --------------

     /1/  Includes  33,600  shares of Common  Stock of the Issuer owned by Aries
          Domestic  Fund II, L.P.,  a Delaware  limited  partnership.  Paramount
          Capital Asset  Management,  Inc.  serves as the general partner of the
          Aries Domestic Fund II, L.P. and has voting and  dispositive  power of
          such shares.



                                       2

<PAGE>

- ----------------------
CUSIP No. 2 232674 101             13D
- ----------------------

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS*
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      3,512,163
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        3,512,163
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         3,512,163
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         7.6%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------



                                       3



<PAGE>

- ----------------------
CUSIP No. 2 232674 101             13D
- ----------------------

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        The Aries Master Fund
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS*
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Cayman Islands
- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      8,448,239
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        8,448,239
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         8,448,239
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         18.4%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*
         OO (see Item 2)
- --------------------------------------------------------------------------------




                                       4
<PAGE>

- ----------------------
CUSIP No. 2 232674 101             13D
- ----------------------

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS*
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      11,994,002 /2/
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        11,994,002 /2/
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         11,994,002 /2/
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         26.2%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------

- --------------------

     /2/  Includes  33,600  shares of Common  Stock of the Issuer owned by Aries
          Domestic Fund II, L.P., a Delaware limited partnership.  Dr. Rosenwald
          is the Chairman of Paramount  Capital Asset  Management,  Inc.,  which
          serves as the general  partner of the Aries  Domestic Fund II, L.P. As
          such, Dr. Rosenwald may be deemed to have voting and dispositive power
          of such shares.




                                       5
<PAGE>

Item 1. Security and Issuer.
        -------------------

        (a)    Common Stock, $0.02 par value ("Shares")

               Cypress Bioscience, Inc. (the "Issuer")
               4350 Executive Drive, Suite 325
               San Diego, CA 92121
               (619) 452-2323

Item 2. Identity and Background.
        -----------------------

        Names of Persons Filing:

        (a)    This  statement  is filed on behalf of  Paramount  Capital  Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
               ("Aries  Domestic"),  Aries Master Fund, a Cayman Island exempted
               company  ("Aries  Fund") and  Lindsay A.  Rosenwald,  M.D.  ("Dr.
               Rosenwald" and collectively,  "Reporting Parties").  See attached
               Exhibit A which is a copy of their  agreement  in writing to file
               this statement on behalf of each of them.

        (b)    Paramount   Capital's,   Aries  Domestic's  and  Dr.  Rosenwald's
               business address is 787 Seventh Avenue, 48th Floor, New York, New
               York,   10019.  The  business  address  for  Aries  Fund  is  c/o
               MeesPierson  (Cayman)  Limited,  P.O. Box 2003,  British American
               Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

        (c)    Dr. Rosenwald is an investment banker,  venture capitalist,  fund
               manager  and  sole  shareholder  of  Paramount  Capital,   /3/  a
               Subchapter S  corporation  incorporated  in  Delaware.  Paramount
               Capital is the General Partner of Aries  Domestic,  /4/ a limited
               partnership  incorporated in Delaware.  Paramount  Capital is the
               Investment  Manager to Aries Fund, /5/ a Cayman Islands  exempted
               company.

        (d)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Fund
               and  their  respective  officers,  directors,  general  partners,
               investment managers,  or trustees have not, during the five years
               prior to the date hereof, been convicted in a criminal proceeding
               (excluding traffic violations or similar misdemeanors).

        (e)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Fund
               and  their  respective  officers,  directors,  general  partners,
               investment  managers,  or trustees have not been, during the five
               years prior to the date hereof,  parties to a civil proceeding of
               a judicial or administrative body of competent jurisdiction, as a
               result of which such  person  was or is  subject  to a  judgment,
               decree  or  final  order  enjoining  future   violations  of,  or
               prohibiting or mandating  activities subject to, Federal or State
               securities  laws or finding any  violation  with  respect to such
               laws.

        (f)    Dr. Rosenwald is a citizen of the United States.

Item 3. Source and Amount of Funds or Other Consideration.
        -------------------------------------------------

               Since the date of Amendment No. 2 to Schedule 13D ("Amendment No.
               2") which was filed on March 9,  1999,  Aries  Domestic  used its
               general  funds to make  certain open market  acquisitions  of the
               securities  of the  Issuer  and the Aries  Fund used its  general
               funds to make certain open market  acquisitions of the securities
               of the Issuer as more fully set forth in

- ---------------------------

              /3/     Please see  attached  Exhibit B indicating  the  executive
                      officers and directors of Paramount  Capital and providing
                      information  called for by Items 2-6 of this  statement as
                      to  said  officers  and  directors.  Exhibit  B is  herein
                      incorporated by reference.

              /4/     Please  see  attached  Exhibit C  indicating  the  general
                      partner  of  Aries  Domestic  and  the  general  partner's
                      executive officers and directors and providing information
                      called  for by  Items  2-6 of  this  statement  as to said
                      general  partners,  officers and  directors.  Exhibit C is
                      herein incorporated by reference.

              /5/     Please see attached  Exhibit D indicating  the  investment
                      manager  of the Aries  Fund and the  investment  manager's
                      executive officers and directors and providing information
                      called  for by  Items  2-6 of  this  statement  as to said
                      investment  manager and officers and directors.  Exhibit D
                      is herein incorporated by reference.



                                       6

<PAGE>

               Item  5.  Aries  Domestic  Fund  II,  L.P.,  a  Delaware  limited
               partnership for which Paramount Capital serves as general partner
               also  used  its  general   funds  to  make  certain  open  market
               acquisitions  of the  securities  of the Issuer as more fully set
               forth in Item 5.  Further,  on April 15, 1999,  the Issuer caused
               173,333 shares of Series A Preferred Stock held by Aries Domestic
               and 493,334 shares of Series A Preferred  Stock held by the Aries
               Fund to be  converted  into shares of Common  Stock.  On the same
               date, Aries Domestic exercised warrants to purchase 37,500 shares
               of Common Stock at an exercise price equal to $1.00 per share and
               the Aries Fund  exercised  warrants to purchase  87,500 shares of
               Common Stock at an exercise price equal to $1.00 per share.

Item 4. Purpose of Transaction.
        -----------------------

               The  Reporting  Parties  acquired  shares of Common  Stock of the
               Issuer as an investment in the Issuer.

               Although the Reporting Parties have not formulated any definitive
               plans, they may from time to time acquire,  or dispose of, Common
               Stock and/or other securities of the Issuer if and when they deem
               it  appropriate.   The  Reporting  Parties  may  formulate  other
               purposes,  plans or proposals  relating to any of such securities
               of the Issuer to the extent  deemed  advisable in light of market
               conditions, investment policies and other factors.

               Except as indicated in this Schedule  13D, the Reporting  Parties
               currently  have no plans or  proposals  that  relate  to or would
               result  in any of the  matters  described  in  subparagraphs  (a)
               through (j) of Item 4 of Schedule 13D.

Item 5. Interest in Securities of the Issuer.
        ------------------------------------

               (a)    As of June 15, 1999, Dr. Rosenwald and Paramount  Capital,
                      through  acquisition  of the  shares by the Aries Fund and
                      Aries Domestic,  beneficially  owned 11,994,002  shares or
                      26.2% of the Issuer's  securities  and Aries Domes tic and
                      the Aries Fund beneficially owned as follows:

                                                          Amount Owned
                                                          ------------
                      Aries Domestic                      3,512,163 Shares
                      Aries Fund                          8,448,239 Shares

               (b)    Dr.  Rosenwald  and  Paramount  Capital share the power to
                      vote or to direct  the vote,  to  dispose or to direct the
                      disposition  of  those  shares  owned  by  each  of  Aries
                      Domestic and Aries Fund.

               (c)    The following purchases were made by Aries Domestic in the
                      open market since the filing of Amendment No. 2:

     Date                   Amount      Price Per Share
     ----                   ------      ---------------

  03/10/1999                  6000          $3.250
  03/11/1999                 6,000          $3.360
  03/12/1999                 6,000          $3.500
  03/15/1999                 4,800          $3.580
  03/16/1999                 4,500          $3.990
  03/17/1999                 1,500          $5.060
  03/17/1999                15,000          $3.820
  03/17/1999                 9,000          $4.040
  03/18/1999                12,000          $3.820
  03/19/1999                13,500          $3.940
  03/22/1999                 3,000          $3.700
  03/23/1999                 3,000          $3.450
  03/23/1999                 3,000          $3.450
  03/24/1999                 3,000          $3.410
  03/24/1999                 6,000          $3.320
  03/25/1999                 3,000          $3.340
  03/25/1999                 6,000          $3.420
  03/26/1999                15,000          $3.680
  03/29/1999                 9,000          $3.870
  03/30/1999                12,000          $3.830



                                        7

<PAGE>

  03/31/1999                24,000          $3.780
  04/05/1999                 9,000          $3.610
  04/06/1999                 9,000          $3.500
  04/07/1999                 9,000          $3.470
  04/08/1999                 9,000          $3.550
  04/09/1999                15,000          $3.560
  04/12/1999                 6,000          $3.530
  04/13/1999                 9,000          $3.500
  04/14/1999                 6,000          $3.460
  04/15/1999                 6,000          $3.550
  04/16/1999                 4,500          $3.690
  04/16/1999                 9,000          $3.670
  04/19/1999                 4,500          $3.560
  04/20/1999                 7,000          $3.380
  04/21/1999                 4,500          $3.420
  04/22/1999                 1,500          $3.450
  04/22/1999                 3,600          $3.440
  04/23/1999                 6,000          $3.590
  04/23/1999                 1,500          $3.540
  04/26/1999                 3,000          $3.630
  04/27/1999                 3,000          $3.900
  04/27/1999                 1,500          $3.990
  04/28/1999                 3,000          $3.840
  04/28/1999                 7,500          $3.770
  04/29/1999                 1,500          $3.860
  04/30/1999                 3,000          $3.780
  04/30/1999                 3,000          $3.810
  04/30/1999                10,500          $3.840
  05/04/1999                 1,490          $3.810
  05/06/1999                 2,970          $3.920
  05/10/1999                 1,480          $4.000
  05/11/1999                 1,480          $3.870
  05/11/1999                 1,480          $4.000
  05/12/1999                 2,970          $3.830
  05/13/1999                 1,480          $3.840
  05/14/1999                14,850          $3.840
  05/17/1999                 1,480          $3.840
  05/18/1999                 2,970          $3.780
  05/18/1999                 1,480          $3.880
  05/19/1999                 2,700          $3.690
  05/20/1999                 1,485          $3.790
  05/21/1999                 7,420          $3.680
  05/24/1999                 2,970          $3.600
  05/24/1999                 2,970          $3.560
  05/25/1999                 1,480          $3.590
  05/25/1999                 2,970          $3.580
  05/26/1999                 2,970          $3.440
  05/26/1999                 4,450          $3.440
  05/27/1999                 2,970          $3.430
  05/27/1999                10,400          $3.510



                                        8

<PAGE>

  05/28/1999                 2,970          $3.590
  05/28/1999                 5,940          $3.540
  05/28/1999                 2,970          $3.590
  06/01/1999                 1,480          $3.430
  06/02/1999                 5,940          $3.200
  06/02/1999                 5,080          $3.160
  06/03/1999                 5,940          $3.380
  06/03/1999                 4,460          $3.346
  06/04/1999                 1,490          $3.406
  06/04/1999                 5,940          $3.430
  06/04/1999                 5,940          $3.480
  06/07/1999                 5,970          $3.422
  06/07/1999                 1,485          $3.435
  06/08/1999                 1,770          $3.375
  06/09/1999                 2,970          $3.500
  06/09/1999                 1,490          $3.469
  06/10/1999                 4,460          $3.367
  06/10/1999                 4,460          $3.393
  06/11/1999                 4,460          $3.426
  06/11/1999                 5,940          $3.456
  06/11/1999                 2,970          $3.438
  06/14/1999                 4,450          $3.310
  06/14/1999                 2,970          $3.377
  06/15/1999                 2,970          $3.188

  The following  purchases  were made by the Aries Fund in the open market since
  the filing of Amendment No. 2:

     Date                   Amount      Price Per Share
     ----                   ------      ---------------

  03/10/1999                 14000          $3.248
  03/11/1999                14,000          $3.359
  03/12/1999                14,000          $3.500
  03/15/1999                11,200          $3.583
  03/16/1999                10,500          $3.993
  03/17/1999                 3,500          $5.063
  03/17/1999                35,000          $3.815
  03/17/1999                21,000          $4.042
  03/18/1999                28,000          $3.823
  03/19/1999                31,500          $3.935
  03/22/1999                 7,000          $3.703
  03/23/1999                 7,000          $3.454
  03/23/1999                 7,000          $3.454
  03/24/1999                 7,000          $3.406
  03/24/1999                14,000          $3.317
  03/25/1999                 7,000          $3.344
  03/25/1999                14,000          $3.424
  03/26/1999                35,000          $3.678
  03/29/1999                21,000          $3.868
  03/30/1999                28,000          $3.828
  03/30/1999                56,000          $3.778
  04/05/1999                21,000          $3.613



                                        9

<PAGE>

  04/06/1999                21,000          $3.500
  04/07/1999                21,000          $3.473
  04/08/1999                21,000          $3.548
  04/09/1999                35,000          $3.559
  04/12/1999                14,000          $3.533
  04/13/1999                11,000          $3.503
  04/14/1999                14,000          $3.457
  04/15/1999                14,000          $3.547
  04/16/1999                10,500          $3.692
  04/16/1999                21,000          $3.667
  04/19/1999                10,500          $3.560
  04/20/1999                 7,000          $3.378
  04/21/1999                10,000          $3.424
  04/22/1999                 3,500          $3.447
  04/22/1999                 8,400          $3.438
  04/23/1999                14,000          $3.589
  04/23/1999                 3,500          $3.543
  04/26/1999                 7,000          $3.626
  04/27/1999                 7,000          $3.904
  04/27/1999                 3,500          $3.985
  04/28/1999                 7,000          $3.835
  04/28/1999                17,500          $3.770
  04/29/1999                 3,500          $3.856
  04/30/1999                 7,000          $3.781
  04/30/1999                 7,000          $3.813
  04/30/1999                24,500          $3.840
  05/04/1999                 3,500          $3.810
  05/06/1999                 7,000          $3.920
  05/07/1999                15,000          $3.975
  05/07/1999                20,000          $3.971
  05/10/1999                 3,500          $3.998
  05/11/1999                 3,500          $3.873
  05/11/1999                 3,500          $4.000
  05/12/1999                 7,000          $3.826
  05/13/1999                 3,500          $3.841
  05/14/1999                35,000          $3.835
  05/17/1999                 3,500          $3.844
  05/18/1999                 7,000          $3.779
  05/18/1999                 3,500          $3.875
  05/19/1999                 7,000          $3.693
  05/20/1999                 3,500          $3.791
  05/21/1999                17,500          $3.677
  05/24/1999                 7,000          $3.597
  05/24/1999                 7,000          $3.563
  05/25/1999                 3,500          $3.589
  05/25/1999                 7,000          $3.580
  05/26/1999                 7,000          $3.444
  05/26/1999                10,500          $3.440
  05/26/1999                 3,000          $3.440
  05/27/1999                 7,000          $3.426



                                       10

<PAGE>

  05/27/1999                24,500          $3.505
  05/28/1999                 7,000          $3.590
  05/28/1999                14,000          $3.535
  05/28/1999                 7,000          $3.590
  06/01/1999                 3,500          $3.430
  06/02/1999                14,000          $3.200
  06/02/1999                11,970          $3.160
  06/03/1999                14,000          $3.380
  06/03/1999                10,500          $3.346
  06/04/1999                 3,500          $3.406
  06/04/1999                14,000          $3.430
  06/04/1999                14,000          $3.480
  06/07/1999                 7,000          $3.422
  06/07/1999                 3,500          $3.435
  06/08/1999                 4,200          $3.375
  06/09/1999                 7,000          $3.500
  06/09/1999                 3,500          $3.469
  06/10/1999                10,500          $3.367
  06/10/1999                10,500          $3.393
  06/11/1999                10,500          $3.426
  06/11/1999                14,000          $3.456
  06/11/1999                 7,000          $3.438
  06/14/1999                10,500          $3.310
  06/14/1999                 7,000          $3.377
  06/15/1999                 7,000          $3.188


  The following  purchases  were made by the Aries Domestic Fund II, L.P. in the
  open market since the filing of Amendment No. 2:

     Date                   Amount      Price Per Share
     ----                   ------      ---------------

  05/03/1999                 31600           $3.94
  05/04/1999                    10           $3.81
  05/06/1999                    30           $3.92
  05/10/1999                    20           $4.00
  05/11/1999                    20           $3.87
  05/11/1999                    20           $4.00
  05/12/1999                    30           $3.83
  05/13/1999                    20           $3.84
  05/14/1999                   150           $3.84
  05/17/1999                    20           $3.84
  05/18/1999                    30           $3.78
  05/18/1999                    20           $3.88
  05/19/1999                   300           $3.69
  05/20/1999                    15           $3.79
  05/21/1999                    80           $3.68
  05/24/1999                    30           $3.60
  05/24/1999                    30           $3.56
  05/25/1999                    20           $3.59
  05/25/1999                    30           $3.58
  05/26/1999                    30           $3.44



                                       11

<PAGE>

  05/26/1999                    50           $3.44
  05/27/1999                    30           $3.43
  05/27/1999                   100           $3.51
  05/28/1999                    60           $3.59
  05/28/1999                    30           $3.54
  05/28/1999                    30           $3.59
  06/01/1999                    20          $3.430
  06/02/1999                    60          $3.200
  06/02/1999                    50          $3.160
  06/03/1999                    60          $3.380
  06/03/1999                    40          $3.346
  06/04/1999                    10          $3.406
  06/04/1999                    60          $3.430
  06/04/1999                    60          $3.480
  06/07/1999                    30          $3.422
  06/07/1999                    15          $3.435
  06/08/1999                    30          $3.375
  06/09/1999                    30          $3.500
  06/09/1999                    10          $3.469
  06/10/1999                    40          $3.367
  06/10/1999                    40          $3.393
  06/11/1999                    40          $3.426
  06/11/1999                    60          $3.456
  06/11/1999                    30          $3.438
  06/14/1999                    50          $3.310
  06/14/1999                    30          $3.377
  06/15/1999                    30          $3.188


  Other than as set forth herein the  Reporting  Parties have not engaged in any
  transactions in the Common Stock of the Issu er since the last filing.

  (d) & (e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with respect to
        Securities of the Issuer
        ------------------------------------------------------------------------

               Paramount Capital is the investment manager of the Aries Fund and
               the General  Partner of Aries Domestic and in such capacities has
               the authority to make certain  investment  decisions on behalf of
               such entities,  including decisions relating to the securities of
               the Issuer. In connection with its investment  management duties,
               Paramount   Capital   receives   certain   management   fees  and
               performance  allocations  from the Aries Fund and Aries Domestic.
               Dr.  Rosenwald  is the sole  shareholder  of  Paramount  Capital.
               Except  as  indicated  in this  13D  and  exhibits,  there  is no
               contract, arrangement, under standing or relationship between the
               Reporting  Parties  and any other  person,  with  respect  to any
               securities of the Issuer.

Item 7. Material to be Filed as Exhibits:
        ---------------------------------

Exhibit A -    Copy of an Agreement  between Dr. Rosenwald,  Paramount  Capital,
               Aries  Domestic and Aries Fund to file this Statement on Schedule
               13D on behalf of each of them.

Exhibit B -    List of executive officers and directors of Paramount Capital and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit C -    List of executive  officers and  directors of Aries  Domestic and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.


                                       12

<PAGE>

Exhibit D -    List of  executive  officers  and  directors  of  Aries  Fund and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.





                                       13


<PAGE>

                                   SIGNATURES
                                   ----------


               After  reasonable  inquiry  and to the best of my  knowledge  and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


                                 PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  June 15, 1999
        New York, NY             By /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman


                                 ARIES DOMESTIC FUND
                                 By  Paramount Capital Asset Management, Inc.
                                      General Partner

Dated:  June 15, 1999
        New York, NY             By /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman


                                 THE ARIES MASTER FUND
                                 By Paramount Capital Asset Management, Inc.
                                 Investment Manager

Dated:  June 15, 1999
        New York, NY             By /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    Chairman


Dated:  June 15, 1999
        New York, NY            By  /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.



                                       14


<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D



               The  undersigned  hereby agrees to jointly  prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each  of the  undersig  ned's  ownership  of  securities  of  Cypress
Bioscience,  Inc.,  and hereby  affirm that such  Schedule 13D is being filed on
behalf of each of the undersigned.


                                PARAMOUNT CAPITAL ASSET MANAGEMENT, INC., INC.

Dated:  June 15, 1999
        New York, NY            By /s/ Lindsay A. Rosenwald. M.D.
                                   -------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                ARIES DOMESTIC FUND, L.P.
                                By Paramount Capital Asset Management, Inc.
                                General Partner

Dated:  June 15, 1999
        New York, NY            By /s/ Lindsay A. Rosenwald   M.D.
                                   -------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                THE ARIES MASTER FUND
                                By Paramount Capital Asset Management, Inc.
                                Investment Manager

Dated:  June 15, 1999
        New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                   -------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman

Dated:  June 15, 1999
        New York, NY            By  /s/ Lindsay A. Rosenwald, M.D.
                                   -------------------------------
                                    Lindsay A. Rosenwald, M.D.



                                       15

<PAGE>

                                    EXHIBIT B

        The name and principal occupation or employment,  which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                              PRINCIPAL OCCUPATION
        NAME                                     OR EMPLOYMENT
        ----                                     -------------
Lindsay A. Rosenwald, M.D.            Chairman of the Board of Paramount Capital
                                      Asset Management,  Inc., Paramount Capital
                                      Investments,  LLC and  Paramount  Capital,
                                      Inc.

Mark C. Rogers, M.D.                  President  of  Paramount   Capital   Asset
                                      Management,    Inc.,   Paramount   Capital
                                      Investments,  LLC and  Paramount  Capital,
                                      Inc.

Peter Morgan Kash                     Director  of   Paramount   Capital   Asset
                                      Management,    Inc.,    Senior    Managing
                                      Director, Paramount Capital, Inc.

Dr. Yuichi Iwaki                      Director  of   Paramount   Capital   Asset
                                      Management, Inc., Professor, University of
                                      Southern California School of Medicine


Item 2.

        During  the  five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.



                                       16

<PAGE>

                                    EXHIBIT C

        The name and principal occupation or employment, which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic is as follows:

                                                  PRINCIPAL OCCUPATION
        NAME                                          OR EMPLOYMENT
        ----                                          -------------

Paramount Capital Asset Management, Inc.     General Partner; Investment Manager

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five years prior to the date hereof, the above person (to the
best of  Aries  Domestic's  knowledge)  has not  been  convicted  in a  criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.



                                       17

<PAGE>

                                    EXHIBIT D

        The name and principal occupation or employment,  which in each instance
is with The Aries Master Fund ("Aries Fund") located at 787 Seventh Avenue, 48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                      PRINCIPAL OCCUPATION
        NAME                                             OR EMPLOYMENT
        ----                                             -------------

Paramount Capital Asset Management, Inc.               Investment Manager

MeesPierson (Cayman) Management Limited                Administrator

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five  years  prior to the date  hereof,  neither of the above
persons  (to the  best of Aries  Fund's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       18


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