CYPRESS BIOSCIENCE INC
SC 13D/A, 1999-05-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934
                               (Amendment No. 23)

                         CYPRESS BIOSCIENCE INCORPORATED
                                (Name of Issuer)

                          Common Stock $0.02 Par Value
                         (Title of Class of Securities)

                                    449695303
                                 (CUSIP Number)

                          Allen & Company Incorporated
           711 Fifth Avenue, New York, New York 10022, (212) 832-8000
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                 April 22, 1999
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of ss.ss. 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the
following box [ ].

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purposes of Section 18 of the  Securities  Exchange Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                     Page 1



<PAGE>
                                 
                                  SCHEDULE 13D
- ---------------------
CUSIP No. 449695303                                            Page 2
- ---------------------

======================================================================
1  NAME OF REPORTING PERSON -
   S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
   ALLEN HOLDING INC.
- ----------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [ ]
(b)  [X]
- ---------------------------------------------------------------------
3  SEC USE ONLY

- ---------------------------------------------------------------------
4  SOURCE OF FUNDS* Not Applicable
- ---------------------------------------------------------------------
5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
   PURSUANT TO ITEMS 2(d) or 2(E)                               [ ]
- ----------------------------------------------------------------------
6  CITIZENSHIP OR PLACE OF ORGANIZATION
   Delaware
- ---------------------------------------------------------------------
   NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
- ----------------------------------------------------------------------
7  SOLE VOTING POWER
   0
- ----------------------------------------------------------------------
8  SHARED VOTING POWER
   0
- ----------------------------------------------------------------------
9  SOLE DISPOSITIVE POWER
   0
- ----------------------------------------------------------------------
10  SHARED DISPOSITIVE POWER
    0
- ----------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    0
- ----------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
    CERTAIN SHARES*                                               [X]
        Excluding 5,533,497 shares
- ----------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
    0.0%
- ----------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*
    HC====================================================================
                   SEE INSTRUCTIONS BELOW BEFORE FILLING OUT!





<PAGE>
                                  SCHEDULE 13D
- ---------------------
CUSIP No. 449695303                                        Page 3
- ---------------------

======================================================================
1  NAME OF REPORTING PERSON -
   S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
   ALLEN & COMPANY INCORPORATED
- ---------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a)  [ ]
                                                             (b)  [X]
- ----------------------------------------------------------------------
3  SEC USE ONLY
- ----------------------------------------------------------------------
4  SOURCE OF FUNDS*
   WC
- ----------------------------------------------------------------------
5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
   PURSUANT TO ITEMS 2(d) or 2(e)                                [ ]
- ----------------------------------------------------------------------
6  CITIZENSHIP OR PLACE OF ORGANIZATION
   New York
- ---------------------------------------------------------------------
   NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
- ---------------------------------------------------------------------
7   SOLE VOTING POWER
 5,533,497 Shares (Includes warrants to purchase 315 shares of Common Stock)
- ----------------------------------------------------------------------
8   SHARED VOTING POWER
    0
- ---------------------------------------------------------------------
9   SOLE DISPOSITIVE POWER
 5,533,497 Shares (Includes warrants to purchase 315 shares of Common Stock)
- ----------------------------------------------------------------------
10  SHARED DISPOSITIVE POWER
    0
- ----------------------------------------------------------------------
11 AGGREGATE AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 5,533,497
  Shares (Includes warrants to purchase 315 shares of Common Stock)
- ----------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
    CERTAIN SHARES*                                             [X]
- ----------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)   13.0%
- ----------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*
    BC,CO
======================================================================
                   *SEE INSTRUCTIONS BELOW BEFORE FILLING OUT!




<PAGE>
                                  SCHEDULE 13D
- ---------------------                             -----------------
CUSIP No. 449695303                                     Page 4
- ---------------------                            ------------------

======================================================================
1   NAME OF REPORTING PERSON -
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Estate of Herbert A. Allen
- ----------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)  [ ]
                                                           (b)  [X]
- ----------------------------------------------------------------------
3  SEC USE ONLY

- ----------------------------------------------------------------------
4  SOURCE OF FUNDS* Not Applicable
- ----------------------------------------------------------------------
5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
   PURSUANT TO ITEMS 2(d) or 2(E)                               [ ]
- ----------------------------------------------------------------------
6  CITIZENSHIP OR PLACE OF ORGANIZATION
   United States
- ----------------------------------------------------------------------
 NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
- ----------------------------------------------------------------------
7  SOLE VOTING POWER
   599,359
- ----------------------------------------------------------------------
8  SHARED VOTING POWER
   0
- ----------------------------------------------------------------------
9  SOLE DISPOSITIVE POWER
   599,359
- ----------------------------------------------------------------------
10 SHARED DISPOSITIVE POWER
   0
- ----------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    599,359
- ----------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
    CERTAIN SHARES*                                            [ ]
- ----------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
    1.4%
- ----------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*
    IN
======================================================================
                   *SEE INSTRUCTIONS BELOW BEFORE FILLING OUT!
SEC 1746 (9-88)


<PAGE>
                                  SCHEDULE 13D
- ---------------------                                     ------------------
CUSIP No. 449695303                                           Page 5
- ---------------------                                    -------------------

=====================================================================
1   NAME OF REPORTING PERSON -
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Bruce Allen
- ----------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a)  [ ]
                                                             (b)  [X]
- ----------------------------------------------------------------------
3  SEC USE ONLY

- ----------------------------------------------------------------------
4  SOURCE OF FUNDS* Not Applicable
- ----------------------------------------------------------------------
5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
   PURSUANT TO ITEMS 2(d) or 2(E)                                [ ]
- ----------------------------------------------------------------------
6  CITIZENSHIP OR PLACE OF ORGANIZATION
   United States
- ----------------------------------------------------------------------
 NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
- ----------------------------------------------------------------------
7  SOLE VOTING POWER
   640,245
- ----------------------------------------------------------------------
8  SHARED VOTING POWER
   0
- ----------------------------------------------------------------------
9  SOLE DISPOSITIVE POWER
   640,245
- ----------------------------------------------------------------------
10 SHARED DISPOSITIVE POWER
   0
- ----------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    640,245
- ----------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
    CERTAIN SHARES*                                             [ ]
- ----------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
    1.5%
- ----------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*
    IN
======================================================================
                   *SEE INSTRUCTIONS BELOW BEFORE FILLING OUT!
SEC 1746 (9-88)



<PAGE>
                                  SCHEDULE 13D
- ---------------------                                   ------------------
CUSIP No. 449695303                                           Page 6
- ---------------------                                  -------------------

======================================================================
1   NAME OF REPORTING PERSON -
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Susan K. Allen
- ----------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a)  [ ]
                                                             (b)  [X]
- ----------------------------------------------------------------------
3  SEC USE ONLY

- ----------------------------------------------------------------------
4  SOURCE OF FUNDS* Not Applicable
- ----------------------------------------------------------------------
5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
   PURSUANT TO ITEMS 2(d) or 2(E)                                 [ ]
- ----------------------------------------------------------------------
6  CITIZENSHIP OR PLACE OF ORGANIZATION
   United States
- ----------------------------------------------------------------------
  NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
- ----------------------------------------------------------------------
7  SOLE VOTING POWER
   1,005,119
- ----------------------------------------------------------------------
8  SHARED VOTING POWER
   0
- ----------------------------------------------------------------------
9  SOLE DISPOSITIVE POWER
   1,005,119
- ----------------------------------------------------------------------
10 SHARED DISPOSITIVE POWER
   0
- ----------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    1,005,119
- ----------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
    CERTAIN SHARES*                                             [ ]
- ----------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
    2.36%
- ----------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*
    IN
=====================================================================
                   *SEE INSTRUCTIONS BELOW BEFORE FILLING OUT!
SEC 1746 (9-88)



<PAGE>
                                  SCHEDULE 13D
- ---------------------                                    ------------------
CUSIP No. 449695303                                            Page 7
- ---------------------                                   -------------------

======================================================================
1   NAME OF REPORTING PERSON -
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
        Richard M. Crooks, Jr.
- ----------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)  [ ]
                                                           (b)  [X]
- ----------------------------------------------------------------------
3  SEC USE ONLY
- ----------------------------------------------------------------------
4  SOURCE OF FUNDS* Not Applicable
- ----------------------------------------------------------------------
5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
   PURSUANT TO ITEMS 2(d) or 2(E)                                [ ]
- ----------------------------------------------------------------------
6  CITIZENSHIP OR PLACE OF ORGANIZATION
   United States
- ----------------------------------------------------------------------
   NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
- ----------------------------------------------------------------------
7  SOLE VOTING POWER
   422,401 Shares (includes 40,000 Common Stock Options)
- ----------------------------------------------------------------------
8  SHARED VOTING POWER
   0
- ----------------------------------------------------------------------
9  SOLE DISPOSITIVE POWER
   422,401 Shares (includes 40,000 Common Stock Options)
- ----------------------------------------------------------------------
10 SHARED DISPOSITIVE POWER
   0
- ----------------------------------------------------------------------
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   422,401 (does not include  certain  shares of the Issuer's  Common Stock
   (the "Shares") owned of record by Allen & Company  Incorporated  ("ACI")
   in which Mr. Crooks may be deemed to have an indirect interest. Pursuant
   to an arrangement with ACI, Mr. Crooks may be deemed to have a pecuniary
   interest  in a portion of certain  securities,  including  the  Issuer's
   Common Stock owned by ACI. Consequently,  Mr. Crooks may realize profits
   from the Shares.)
- ----------------------------------------------------------------------



<PAGE>
                                  SCHEDULE 13D
- ---------------------                                      ------------------
CUSIP No. 449695303                                               Page 8
- ---------------------                                     -------------------


- ----------------------------------------------------------------------
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
    CERTAIN SHARES*                                            [ ]
- ----------------------------------------------------------------------
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        1.0%
- ----------------------------------------------------------------------
14  TYPE OF REPORTING PERSON*
    IN
======================================================================
                   *SEE INSTRUCTIONS BELOW BEFORE FILLING OUT!
SEC 1746 (9-88)



<PAGE>                                                           Page 9

                                AMENDMENT NO. 23
                                       TO
                                  SCHEDULE 13D


                 The Reporting Persons hereby amend their Schedule 13D relating
to the Common Stock,  $0.02 per share of Cypress  BioScience  Incorporation (the
"Issuer")  principally  to reflect  the  "cashless"  exercise by Allen & Company
Incorporated  ("ACI") of a total of 228,000 shares of the Issuer's Common Stock.
In this Amendment, the Reporting Persons have omitted certain formerly reporting
persons for one of the following  reasons:  (i) they no longer own any shares of
Common Stock,  (ii) they own a de minimus amount of Common Stock,  or (iii) they
are no longer  associated with Allen Holding Inc.  ("AHI") or ACI. The Reporting
Persons have also omitted trades made in ACI's capacity as a market maker.

Item 3. Source and Amount of Funds or Other Consideration.

                  Pursuant  to the  April  20,  1998  "cashless"  exercise  of a
warrant  for 228,000  shares of Common  Stock,  ACI  received  37,668  shares of
restricted Common Stock.

Item 5. Interest in Securities of the Issuer

                  (a) As of the  close  of  business  on  April  20,  1998,  the
Reporting  Persons,  by virtue of the  language of Rule  13d-3(d)(1)(i),  may be
deemed to own  beneficially  in the aggregate  the number and  percentage of the
Issuer's  Common Stock set forth below (based upon  information  provided by the
Issuer in its Annual  report on Form  10-K405,  which reports that the number of
shares of Common Stock outstanding, as of March 1, 1999 is 42,607,582).

<TABLE>
<CAPTION>
=================================================================
Name                                   Shares          Percentage
- -----------------------------------------------------------------
<S>                                    <C>                 <C>
Allen Holding Inc.                      0  (1)            0.0%
Allen & Company Incorporated    5,533,497  (2)           13.0%
Estate of Herbert A. Allen        599,359                 1.4%
Bruce Allen                       640,245                 1.5%
Susan K. Allen                  1,005,119                2.36%
Richard M. Crooks, Jr.            422,401  (3)            1.0%

</TABLE>
- -------------

(1)      Excludes shares owned indirectly  through Allen & Company  Incorporated
         ("ACI").  Also, excludes certain shares owned by officers and directors
         of Allen Holding Inc.



<PAGE>                                                         Page 10


(2)      Excludes 1,347 shares in market making accounts.  Excludes certain
shares owned by officers and directors of ACI.

(3)      Including 40,000 Common Stock Options


         (c) No transactions  were effected by the Reporting  Persons within the
past 60 days,  other  than the  purchase  described  above in Item 3 and  trades
related to ACI's position as a market maker.

         Item 7.  Material to be Filed as Exhibits.

         Exhibit A:  Officers and Directors of Allen Holding Inc. and  Officers
and Directors of Allen & Company Incorporated





<PAGE>                                                       Page 11


         After  reasonable  inquiry and to the best of our knowledge and belief,
each of the  signatories  certifies  that  the  information  set  forth  in this
Schedule relating to the respective signatory is true, complete and correct.

Dated:  May 12, 1999

ALLEN HOLDING INC.                                 ALLEN & COMPANY INCORPORATED


By: /s/ Gaetano J. Casillo                          By:  /s/ Gaetano J. Casillo
   -------------------------                           ------------------------
   Name:  Gaetano J. Casillo                          Name:  Gaetano J. Casillo
   Title:  Vice President                                Title:  Vice President




<PAGE>                                                          Page 12

<TABLE>
<CAPTION>
                                    EXHIBIT A

                  OFFICERS AND DIRECTORS OF ALLEN HOLDING INC.
                           AND ALLEN & COMPANY INCORPORATED

      <S>               <C>                          <C>
                                            Principal Occupation (i.e.,
                     Business               Position with Allen Holdings Inc.
     Name xx         Address                and Allen & Company Incorporated)

Herbert A. Allen        x           President, Managing Director,
                                    Director, Chief Executive Officer

Herbert A. Allen III    x           Vice President, Director

Grace Allen             x           Director

Glenn A. Andreas III    x           Vice President - Elect

Eran S. Ashany          x           Vice President, Director

Edmund M. Bleich        x           Vice President

Jay B. Bockhaus         x           Vice President - Elect

Denise Calvo-Silver     x           Vice President, Director

Dominick J. Cantalupo   x           Co-Chief Operations Officer,
                                    Vice-President

Marvyn Carton           x           Director - Emeritus

Gaetano J. Casillo      x           Chief Compliance Officer,
                                    Vice President

Toby R. Coppel          x           Vice President - Elect

Robert H. Cosgriff      x           Chief Administrative Officer,
                                     Executive Vice President,
                                    Managing Director, Director

Richard M. Crooks, Jr.  x           Director

Thalia V. Crooks        x           Vice President, Director

Mary L. Cullen          x           Vice President, Secretary, Director

Robert A. Dean          x           Vice President, Director





<PAGE>                                                          Page 13

       <S>               <C>                                  <C>
                                            Principal Occupation (i.e.,
                     Business               Position with Allen Holdings Inc.
     Name xx         Address                and Allen & Company Incorporated)


Orin F. Devereux        x               Vice President, Director

Daniel Englander        x               Vice President - Elect

Howard M. Felson        x               Assistant Secretary, Vice
                                        President, Controller

Anthony J. Ferrante     x               Treasurer

Richard L. Fields       x               Executive Vice President, Managing
                                        Director, Director

Paul A. Gould           x               Executive Vice President, Managing
                                        Director, Director

John G. Hall            x               Vice President, Director

George N. Jeppson       x               Vice President-Elect

John H. Josephson       x               Vice President, Director

Clarke R. Keough        x               Vice President, Director

Donald R. Keough        x               Chairman of the Board, Managing
                                        Director, Director

Kaveh A. Khosrowshahi   x               Vice President, Director

LeRoy Kim               x               Vice President - Elect

Neal Kopp               x               Vice President

Terry Allen Kramer      x               Director

Irwin H. Kramer         x               Executive Vice President,
                                        Managing Director, Director

Suzanne G. Kucera       x               Vice President, Director

Robert J. Kurz          x               Vice President

Andreas L. Lazar        x               Vice President-Elect

William F. Leimkuhler   x               Assistant Secretary, Vice
                                        President, General Counsel



<PAGE>                                                        Page 14

       <S>               <C>                                  <C>
                                    Principal Occupation (i.e.,
                     Business       Position with Allen Holdings Inc.
     Name xx         Address        and Allen & Company Incorporated)

Jonathan A. Lipton      x           Vice President - Elect

Dan W. Lufkin           x           Special Advisor to the Board of
                                    Directors
Robert A. Mackie        x           Executive Vice President,
                                    Managing Director, Director

James C. Maiden, Jr.    x           Vice President

Terence C. McCarthy     x           Co-Chief Operations Officer,
                                    Vice President

Robert C. Miller        x           Vice President, Director

Kenneth L. Miltonberger x           Chief Technology Officer

Terrence C. Morris      x           Vice President - Elect

Brian J. Murphy         x           Vice President, Director

Louis J. Mustacchio     x           Vice President

Walter T. O'Hara, Jr.   x           Executive Vice President, Managing
                                    Director, Director

Christine R. Olenchalk  x           Vice President

Nancy B. Peretsman      x           Executive Vice President, Managing
                                    Director, Director

Patrick S. Perry        x           Vice President, Director

Eugene Protash          x           Vice President, Assistant Secretary

James W. Quinn          x           Director, Vice President

James S. Rubin          x           Vice President - Elect

Daniel J. Sapadin       x           Vice President - Elect

Philip D. Scaturro      x           Executive Vice President, Managing
                                    Director, Director

John A. Schneider       x           Executive Vice President, Managing
                                    Director, Director



<PAGE>                                                      Page 15

       <S>               <C>                 <C>
                                   Principal Occupation (i.e.,
                     Business      Position with Allen Holdings Inc.
     Name xx         Address       and Allen & Company Incorporated)

Daniel J. Selmonosky    x          Vice President, Director

Enrique F. Senior       x          Executive Vice President, Managing
                                   Director, Director

Joseph E. Sheehan       x          Vice President - Elect

Stanley S. Shuman       x          Executive Vice President, Managing
                                   Director, Director
John M. Simon           x          Executive Vice President, Managing
                                   Director, Director

Kenneth M. Siskind      x          Vice President - Elect

Ian G. Smith            x          Vice President - Elect

Everett K. Wallace      x          Vice President - Elect

Dennis J. Warfield      x          Vice President, Chief Information
                                    Officer
Kim M. Wieland          x          Executive Vice President, Managing
                                   Director, Director, Chief Financial
                                   Officer

Edward D. Weinberger    x          Director

</TABLE>


x                 711 Fifth Avenue, New York, New York 10022-3194.

xx                All the Executive Officers and Directors of Allen Holding Inc.
and Allen & Company Incorporated are U.S. citizens unless otherwise indicated.



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