CYPRESS BIOSCIENCE INC
SC 13D/A, 1999-08-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D
                                (Amendment No.4)

                    Under the Securities Exchange Act of 1934


                            Cypress Bioscience, Inc.
                                (Name of Issuer)


                     Common Stock, par value $.02 per share
                         (Title of Class of Securities)

                                  2 232674 101
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300
                                 with a copy to:

                              Monica C. Lord, Esq.
                       Kramer Levin Naftalis and Frankel
                                 919 3rd Avenue
                               New York, NY 10021
                                 (212) 715-9100

                     (Name, Address and Telephone Number of
            Person Authorized to Receive Notices and Communications)


                                  July 11, 1999
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this Schedule 13D, and is filing this
Schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g) check the following: [ ]

<PAGE>

- --------------------------------------------------------------------------------
1          NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                        (a) [ ]     (b) [ ]
- --------------------------------------------------------------------------------
3          SEC USE ONLY

- --------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           OO (see Item 3 below)
- --------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEM 2(d) or 2(e)                                      [ ]
- --------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION
           Delaware
- --------------------------------------------------------------------------------
                NUMBER OF                 7         SOLE VOTING POWER
                 SHARES                             None
              BENEFICIALLY                --------------------------------------
                OWNED BY                  8         SHARED VOTING POWER
                  EACH                              13,027,893
                REPORTING                 --------------------------------------
                 PERSON                   9         SOLE DISPOSITIVE POWER
                  WITH                              None
                                          --------------------------------------
                                          10        SHARED DISPOSITIVE POWER
                                                    13,027,893
- --------------------------------------------------------------------------------
11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           13,027,893
- --------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                 [ ]
- --------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           28.3%

- --------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*
           CO
- --------------------------------------------------------------------------------

<PAGE>

- --------------------------------------------------------------------------------
1          NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                        (a) [ ]      (b) [ ]
- --------------------------------------------------------------------------------
3          SEC USE ONLY

- --------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           OO (see Item 3 below)
- --------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEM 2(d) or 2(e)                                   [ ]
- --------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION
           Delaware
- --------------------------------------------------------------------------------
                NUMBER OF                 7         SOLE VOTING POWER
                 SHARES                             None
              BENEFICIALLY                --------------------------------------
                OWNED BY                  8         SHARED VOTING POWER
                  EACH                              3,855,371
                REPORTING                 --------------------------------------
                 PERSON                   9         SOLE DISPOSITIVE POWER
                  WITH                              None
                                          --------------------------------------
                                          10        SHARED DISPOSITIVE POWER
                                                    3,855,371
- --------------------------------------------------------------------------------
11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           3,855,371
- --------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                              [ ]
- --------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           8.4%
- --------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*
           PN
- --------------------------------------------------------------------------------

<PAGE>

- --------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       The Aries Master Fund
- --------------------------------------------------------------------------------
2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                         (a) [ ]    (b) [ ]
- --------------------------------------------------------------------------------
3          SEC USE ONLY

- --------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           OO (see Item 3 below)
- --------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEM 2(d) or 2(e)
- --------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION
           Delaware
- --------------------------------------------------------------------------------
                NUMBER OF                 7         SOLE VOTING POWER
                 SHARES                             None
              BENEFICIALLY                --------------------------------------
                OWNED BY                  8         SHARED VOTING POWER
                  EACH                              8,974,664
                REPORTING                 --------------------------------------
                 PERSON                   9         SOLE DISPOSITIVE POWER
                  WITH                              None
                                          --------------------------------------
                                          10        SHARED DISPOSITIVE POWER
                                                    8,974,664
- --------------------------------------------------------------------------------
11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           8,974,664
- --------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                 [ ]
- --------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           19.5%
- --------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*
           CO
- --------------------------------------------------------------------------------

<PAGE>

- --------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                           (a) [ ]    (b) [ ]
- --------------------------------------------------------------------------------
3          SEC USE ONLY

- --------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           OO (see Item 3 below)
- --------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEM 2(d) or 2(e)                                         [ ]
- --------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION
           United States
- --------------------------------------------------------------------------------
                NUMBER OF                 7         SOLE VOTING POWER
                 SHARES                             None
              BENEFICIALLY                --------------------------------------
                OWNED BY                  8         SHARED VOTING POWER
                  EACH                              13,027,893
                REPORTING                 --------------------------------------
                 PERSON                   9         SOLE DISPOSITIVE POWER
                  WITH                              None
                                          --------------------------------------
                                          10        SHARED DISPOSITIVE POWER
                                                    13,027,893
- --------------------------------------------------------------------------------
11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           13,027,893
- --------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                  [ ]
- --------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           28.3%
- --------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*
           IN
- --------------------------------------------------------------------------------

<PAGE>

Item 1.  Security and Issuer.

          (a)       Common Stock, $0.02 par value ("Shares")

                    Cypress   Bioscience,  Inc. (the  "Issuer")  4350  Executive
                    Drive,   Suite  325  San  Diego,  CA  92121  (619) 452-2323

Item 2.  Identity and Background.

         Names of Persons Filing:

          (a)       This statement is filed on behalf of Paramount Capital Asset
                    Management, Inc. ("Paramount Capital"), Aries Domestic Fund,
                    L.P. ("Aries Domestic"),  Aries Master Fund, a Cayman Island
                    exempted  company  ("Aries Fund") and Lindsay A.  Rosenwald,
                    M.D.   ("Dr.   Rosenwald"   and   collectively,   "Reporting
                    Parties").  The  shares of Common  Stock  that may be deemed
                    beneficially  owned by Paramount  Capital and Dr.  Rosenwald
                    include  197,858 shares held by Aries Domestic Fund II, L.P.
                    ("Aries II").  Paramount Capital and Dr. Rosenwald  disclaim
                    membership in a group with Aries II, and  Paramount  Capital
                    and  Dr.  Rosenwald  disclaim  beneficial  ownership  of the
                    shares  held by Aries  II,  except  to the  extent  of their
                    respective  pecuniary interests though, if any. See attached
                    Exhibit A which is a copy of their  agreement  in writing to
                    file this statement on behalf of each of them.

          (b)       Paramount  Capital's,  Aries Domestic's and Dr.  Rosenwald's
                    business  address is 787 Seventh  Avenue,  48th  Floor,  New
                    York, New York,  10019.  The business address for Aries Fund
                    is c/o MeesPierson (Cayman) Limited,  P.O. Box 2003, British
                    American  Centre,  Phase 3, Dr.  Roy's  Drive,  George Town,
                    Grand Cayman.

          (c)       Dr. Rosenwald is an investment banker,  venture  capitalist,
                    fund manager and sole shareholder of Paramount Capital/1/, a
                    Subchapter S corporation incorporated in Delaware. Paramount
                    Capital  is the  General  Partner  of Aries  Domestic/2/,  a
                    limited  partnership  incorporated  in  Delaware.  Paramount
                    Capital is the Investment Manager to Aries Fund/3/, a Cayman
                    Islands exempted company.

          (d)       Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries
                    Fund  and  their  respective  officers,  directors,  general
                    partners,  investment managers, or trustees have not, during
                    the five years prior to the date hereof, been convicted in a
                    criminal proceeding (excluding traffic violations or similar
                    misdemeanors).

          (e)       Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries
                    Fund  and  their  respective  officers,  directors,  general
                    partners,  investment  managers,  or trustees have not been,
                    during the five years prior to the date hereof, parties to a
                    civil  proceeding  of a judicial or  administrative  body of
                    competent jurisdiction, as a result of which such person was
                    or is subject to a judgment, decree or final order enjoining
                    future violations of, or prohibiting or mandating activities
                    subject to, Federal or State  securities laws or finding any
                    violation with respect to such laws.

          (f)       Dr. Rosenwald is a citizen of the United States.

- ----------------------
/1/  Please  see  attached  Exhibit B  indicating  the  executive  officers  and
directors of Paramount Capital and providing information called for by Items 2-6
of this  statement  as to said  officers  and  directors.  Exhibit  B is  herein
incorporated by reference.

/2/  Please see  attached  Exhibit C  indicating  the  general  partner of Aries
Domestic  and  the  general  partner's  executive  officers  and  directors  and
providing  information  called  for by Items  2-6 of this  statement  as to said
general partners,  officers and directors.  Exhibit C is herein  incorporated by
reference

/3/ Please see attached Exhibit D indicating the investment manager of the Aries
Fund and the investment manager's executive officers and directors and providing
information  called  for by Items 2-6 of this  statement  as to said  investment
manager  and  officers  and  directors.  Exhibit  D is  herein  incorporated  by
reference.

<PAGE>
Item 3.  Source and Amount of Funds or Other Consideration.

                  Since the date of Amendment No. 3 to Schedule 13D  ("Amendment
                  No. 1") which was filed on June 21, 1999,  Aries Domestic used
                  its general funds to make certain open market  acquisitions of
                  the  securities  of the  Issuer  and the  Aries  Fund used its
                  general funds to make certain open market  acquisitions of the
                  securities  of the  Issuer as more  fully set forth in Item 5.
                  Aries Domestic Fund II, L.P., a Delaware  limited  partnership
                  for which  Paramount  Capital  serves as general  partner also
                  used  its   general   funds  to  make   certain   open  market
                  acquisitions of the securities of the Issuer as more fully set
                  forth in Item 5.

Item 4.  Purpose of Transaction.

                  The Reporting  Parties  acquired shares of Common Stock of the
                  Issuer as an investment in the Issuer.

                  Although  the  Reporting   Parties  have  not  formulated  any
                  definitive  plans,  they may  from  time to time  acquire,  or
                  dispose of, Common Stock and/or other securities of the Issuer
                  if and when they deem it  appropriate.  The Reporting  Parties
                  may formulate other purposes,  plans or proposals  relating to
                  any of such  securities  of the  Issuer to the  extent  deemed
                  advisable in light of market conditions,  investment  policies
                  and other factors.

                  Except  as  indicated  in this  Schedule  13D,  the  Reporting
                  Parties currently have no plans or proposals that relate to or
                  would result in any of the matters  described in subparagraphs
                  (a) through (j) of Item 4 of Schedule 13D.

Item 5.  Interest in Securities of the Issuer.

                  (a)      As of August 17, 1999,  Dr.  Rosenwald  and Paramount
                           Capital,  through  acquisition  of the  shares by the
                           Aries  Fund and Aries  Domestic,  beneficially  owned
                           13,027,893 shares or 28.3% of the Issuer's securities
                           and Aries  Domestic  and the Aries Fund  beneficially
                           owned as follows:
                                                            Amount Owned
                                                            ------------
                           Aries Domestic                   3,855,371 Shares
                           Aries Fund                       8,974,664 Shares

                  (b)      Dr.  Rosenwald and Paramount  Capital share the power
                           to vote or to  direct  the  vote,  to  dispose  or to
                           direct the  disposition of those shares owned by each
                           of Aries Domestic and Aries Fund.

                  (c)      The following  purchases  were made by Aries Domestic
                           in the open market since the filing of Amendment  No.
                           3:
                          Date                  Amount         Price Per Share
                          ----                  ------         ---------------
                          06/15/99              2,970              $ 3.272
                          06/16/99              2,970              $ 3.365
                          06/16/99              2,970              $ 3.318
                          06/17/99              2,970              $ 3.380
                          06/17/99              1,485              $ 3.469
                          06/18/99              4,455              $ 3.271
                          06/18/99             11,880              $ 3.100
                          06/18/99              7,425              $ 3.270
                          06/21/99              2,970              $ 3.156
                          06/21/99              3,861              $ 3.219
                          06/22/99              8,910              $ 3.300
                          06/22/99              1,480              $ 3.281
                          06/23/99              1,480              $ 3.225
                          06/23/99                145              $ 3.125
                          06/23/99              2,970              $ 3.250
                          06/24/99              2,970              $ 3.219
                          06/24/99              5,049              $ 3.195

<PAGE>
                          06/24/99              1,200              $ 3.250
                          06/24/99              2,970              $ 3.125
                          06/25/99              8,910              $ 3.125
                          06/25/99              1,480              $ 3.125
                          06/25/99              5,940              $ 3.154
                          06/29/99              1,480              $ 3.094
                          06/29/99              1,480              $ 3.154
                          06/29/99              5,940              $ 3.185
                          06/30/99              1,450              $ 3.125
                          06/30/99              1,450              $ 3.248
                          06/30/99             10,150              $ 3.220
                          07/02/99              5,000              $ 3.123
                          07/06/99              5,000              $ 3.123
                          07/07/99              1,500              $ 3.091
                          07/08/99              3,000              $ 3.065
                          07/08/99              4,500              $ 3.090
                          07/09/99             10,000              $ 3.055
                          07/09/99             28,000              $ 3.040
                          07/09/99              5,000              $ 3.000
                          07/09/99             15,000              $ 3.031
                          07/09/99              5,000              $ 3.065
                          07/12/99              1,500              $ 3.000
                          07/12/99              1,500              $ 3.000
                          07/13/99             10,000              $ 2.984
                          07/13/99             25,000              $ 2.920
                          07/13/99              3,000              $ 3.000
                          07/19/99              5,000              $ 2.938
                          07/19/99              4,534              $ 3.000
                          07/20/99              1,493              $ 3.031
                          07/20/99              9,371              $ 3.023
                          07/20/99              1,493              $ 3.000
                          07/20/99              1,493              $ 2.982
                          07/21/99              1,493              $ 3.000
                          07/22/99              1,493              $ 2.875
                          07/23/99              2,986              $ 2.935
                          07/23/99              4,479              $ 2.875
                          07/26/99              1,493              $ 2.940
                          07/27/99              2,986              $ 2.935
                          07/28/99              1,493              $ 2.875
                          07/28/99              2,986              $ 2.938
                          07/28/99              2,986              $ 2.935
                          07/29/99              1,493              $ 2.774
                          07/29/99              8,958              $ 2.894
                          07/29/99                299              $ 2.719
                          07/30/99              5,972              $ 2.880
                          07/30/99              4,479              $ 2.896
                          08/02/99              1,480              $ 2.685
                          08/05/99                917              $ 2.750

<PAGE>

                          08/05/99              1,480              $ 2.746
                          08/06/99              8,877              $ 2.677
                          08/06/99              5,918              $ 2.720
                          08/09/99              1,480              $ 2.630
                          08/09/99              1,480              $ 2.563
                          08/10/99              1,480              $ 2.613
                          08/10/99              2,959              $ 2.611
                          08/11/99              2,959              $ 2.547
                          08/11/99              2,959              $ 2.500
                          08/12/99              1,480              $ 2.790
                          08/12/99              1,480              $ 2.550
                          08/13/99              2,959              $ 2.664
                          08/13/99              1,480              $ 2.688
                          08/16/99              1,480              $ 2.750
                          08/16/99              1,480              $ 2.763
                          08/17/99              1,480              $ 2.810

                           The following  purchases  were made by the Aries Fund
                           in the open market since the filing of Amendment  No.
                           3:

                           Date               Amount           Price Per Share
                           ----               ------           ---------------

                          06/15/99             7,000               $ 3.272
                          06/16/99             7,000               $ 3.365
                          06/16/99             7,000               $ 3.318
                          06/17/99             7,000               $ 3.380
                          06/17/99             3,500               $ 3.469
                          06/18/99            10,500               $ 3.271
                          06/18/99            28,000               $ 3.100
                          06/18/99            17,500               $ 3.270
                          06/21/99             7,000               $ 3.156
                          06/21/99             9,100               $ 3.219
                          06/22/99            21,000               $ 3.300
                          06/22/99             3,500               $ 3.281
                          06/23/99             3,500               $ 3.225
                          06/23/99               350               $ 3.125
                          06/23/99             7,000               $ 3.250
                          06/24/99            11,900               $ 3.195
                          06/24/99             7,000               $ 3.125
                          06/24/99             7,000               $ 3.219
                          06/24/99             2,835               $ 3.250
                          06/25/99            21,000               $ 3.125
                          06/25/99             3,500               $ 3.125
                          06/25/99            14,000               $ 3.154
                          06/28/99            10,000               $ 3.216
                          06/28/99             5,000               $ 3.125
                          06/29/99             3,500               $ 3.094
                          06/29/99             3,500               $ 3.154
                          06/29/99            14,000               $ 3.185
                          06/30/99             3,500               $ 3.125

<PAGE>

                          06/30/99             3,500               $ 3.248
                          06/30/99            24,500               $ 3.220
                          07/07/99             3,450               $ 3.091
                          07/08/99             6,900               $ 3.065
                          07/08/99            10,350               $ 3.090
                          07/12/99             3,450               $ 3.000
                          07/12/99             3,450               $ 2.934
                          07/13/99             7,000               $ 3.091
                          07/20/99             3,411               $ 3.031
                          07/20/99               617               $ 3.023
                          07/20/99             3,411               $ 3.000
                          07/20/99             3,411               $ 2.982
                          07/21/99             3,411               $ 3.000
                          07/22/99             3,411               $ 2.875
                          07/22/99             5,000               $ 2.938
                          07/23/99             6,882               $ 2.935
                          07/23/99            10,323               $ 2.875
                          07/26/99             3,441               $ 2.940
                          07/27/99             6,882               $ 2.938
                          07/27/99             6,882               $ 2.935
                          07/28/99             6,882               $ 2.935
                          07/28/99             3,441               $ 2.875
                          07/29/99             3,441               $ 2.774
                          07/29/99            20,646               $ 2.894
                          07/29/99               688               $ 2.719
                          07/30/99            13,764               $ 2.880
                          07/30/99            10,323               $ 2.896
                          08/02/99             3,440               $ 2.685
                          08/05/99             2,133               $ 2.750
                          08/05/99             3,440               $ 2.746
                          08/06/99            20,640               $ 2.677
                          06/06/99            13,760               $ 2.720
                          08/09/99             3,440               $ 2.630
                          08/09/99             3,440               $ 2.563
                          08/10/99             3,440               $ 2.613
                          08/10/99             6,880               $ 2.611
                          08/11/99             6,880               $ 2.547
                          08/11/99             6,880               $ 2.500
                          08/12/99             3,440               $ 2.790
                          08/12/99             3,440               $ 2.550
                          08/13/99             3,440               $ 2.664
                          08/13/99             6,880               $ 2.688
                          08/16/99             3,440               $ 2.750
                          08/16/99             3,440               $ 2.763
                          08/17/99             3,440               $ 2.810


                    The following purchases were made by the Aries Domestic Fund
                    II, L.P. in the open  market  since the filing of  Amendment
                    No. 3:

<PAGE>

                            Date                Amount         Price Per Share
                            ----                ------         ---------------
                           6/15/99                 30               $ 3.272
                           6/16/99                 30               $ 3.365
                           6/16/99                 30               $ 3.318
                           6/17/99                 30               $ 3.380
                           6/17/99                 15               $ 3.469
                           6/18/99                 45               $ 3.271
                           6/18/99                120               $ 3.100
                           6/18/99                 75               $ 3.270
                           6/21/99                 30               $ 3.156
                           6/21/99                 39               $ 3.219
                           6/22/99                 90               $ 3.300
                           6/22/99                 20               $ 3.281
                           6/23/99                 20               $ 3.225
                           6/23/99                 5                $ 3.125
                           6/23/99                 30               $ 3.250
                           6/24/99                 51               $ 3.195
                           6/24/99                 30               $ 3.125
                           6/24/99                 30               $ 3.219
                           6/24/99                 15               $ 3.250
                           6/25/99                 90               $ 3.125
                           6/25/99                 20               $ 3.125
                           6/25/99                 60               $ 3.154
                           6/29/99                 20               $ 3.094
                           6/29/99                 20               $ 3.154
                           6/29/99                 60               $ 3.185
                           6/30/99                 50               $ 3.125
                           6/30/99                 50               $ 3.248
                           6/30/99                350               $ 3.220
                           6/30/99              5,500               $ 3.094
                           07/01/99             5,000               $ 3.094
                           07/01/99             5,000               $ 3.245
                           07/07/99                50               $ 3.091
                           07/08/99               100               $ 3.065
                           07/08/99               150               $ 3.090
                           07/12/99                50               $ 3.000
                           07/12/99                50               $ 2.934
                           07/13/99             5,000               $ 2.938
                           07/14/99             5,000               $ 2.938
                           07/14/99            15,000               $ 2.988
                           07/15/99             5,000               $ 2.875
                           07/15/99            15,000               $ 2.823
                           07/15/99            20,000               $ 2.830
                           07/15/99             5,000               $ 3.000
                           07/16/99             5,000               $ 2.882
                           07/16/99            20,000               $ 2.950
                           07/19/99             5,000               $ 2.719

<PAGE>

                           07/19/99             5,466               $ 3.000
                           07/20/99                66               $ 3.031
                           07/20/99                12               $ 3.023
                           07/20/99                66               $ 3.000
                           07/20/99                66               $ 2.982
                           07/21/99                66               $ 3.000
                           07/22/99                66               $ 2.875
                           07/23/99               132               $ 2.935
                           07/23/99               198               $ 2.875
                           07/26/99                66               $ 2.940
                           07/27/99               132               $ 2.935
                           07/27/99               132               $ 2.938
                           07/28/99               132               $ 2.935
                           07/28/99                66               $ 2.875
                           07/29/99                66               $ 2.774
                           07/29/99               396               $ 2.894
                           07/29/99                13               $ 2.719
                           07/30/99               264               $ 2.880
                           07/30/99               198               $ 2.896
                           08/02/99                81               $ 2.685
                           08/02/99             5,000               $ 2.813
                           08/03/99            10,000               $ 2.991
                           08/04/99            15,000               $ 2.708
                           08/04/99             5,000               $ 2.688
                           08/05/99             1,950               $ 2.750
                           08/05/99                80               $ 2.746
                           08/06/99               483               $ 2.677
                           08/06/99               322               $ 2.720
                           08/09/99                80               $ 2.630
                           08/09/99                80               $ 2.563
                           08/10/99                80               $ 2.613
                           08/10/99               161               $ 2.611
                           08/11/99               161               $ 2.547
                           08/11/99               161               $ 2.500
                           08/12/99                80               $ 2.790
                           08/12/99                80               $ 2.550
                           08/13/99               161               $ 2.664
                           08/13/99                80               $ 2.688
                           08/16/99                80               $ 2.750
                           08/16/99                80               $ 2.763
                           08/17/99                80               $ 2.810

                  Other than as set forth herein the Reporting  Parties have not
                  engaged in any  transactions in the Common Stock of the Issuer
                  since the last filing.

                  (d) & (e)         Not applicable.

Item 6.  Contracts, Arrangements, Understandings or Relationships
                  with respect to Securities of the Issuer

<PAGE>

                  Paramount Capital is the investment  manager of the Aries Fund
                  and  the  General  Partner  of  Aries  Domestic  and  in  such
                  capacities  has  the  authority  to  make  certain  investment
                  decisions  on behalf  of such  entities,  including  decisions
                  relating to the securities of the Issuer.  In connection  with
                  its investment  management duties,  Paramount Capital receives
                  certain  management fees and performance  allocations from the
                  Aries  Fund and  Aries  Domestic.  Dr.  Rosenwald  is the sole
                  shareholder of Paramount Capital.  Except as indicated in this
                  13D  and   exhibits,   there  is  no  contract,   arrangement,
                  understanding  or relationship  between the Reporting  Parties
                  and any other  person,  with respect to any  securities of the
                  Issuer.

Item 7.  Material to be Filed as Exhibits:

Exhibit A -       Copy of an Agreement between Dr. Rosenwald, Paramount Capital,
                  Aries  Domestic  and  Aries  Fund to file  this  Statement  on
                  Schedule 13D on behalf of each of them.

Exhibit B -       List of executive  officers and directors of Paramount Capital
                  and  information  called  for by Items  2-6 of this  statement
                  relating to said officers and directors.

Exhibit C -       List of executive officers and directors of Aries Domestic and
                  information called for by Items 2-6 of this statement relating
                  to said officers and directors.

Exhibit D -       List of  executive  officers  and  directors of Aries Fund and
                  information called for by Items 2-6 of this statement relating
                  to said officers and directors.

<PAGE>

                                   SIGNATURES


                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


                                      PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:     August 19, 1999
           New York, NY               By /s/ Lindsay A. Rosenwald, M.D.
                                        ---------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            Chairman


                                      ARIES DOMESTIC FUND
                                      By  Paramount Capital Asset Management,
                                          Inc.
                                             General Partner

Dated:     August 19, 1999
           New York, NY               By /s/ Lindsay A. Rosenwald, M.D.
                                        ---------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            Chairman


                                      THE ARIES MASTER FUND
                                      By Paramount Capital Asset Management,
                                      Inc.
                                      Investment Manager

Dated:     August 19, 1999
           New York, NY               By /s/ Lindsay A. Rosenwald, M.D.
                                        ------------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            Chairman


Dated:     August 19, 1999
           New York, NY              By  /s/ Lindsay A. Rosenwald, M.D.
                                       -------------------------------------
                                            Lindsay A. Rosenwald, M.D.


<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D


                  The undersigned hereby agrees to jointly prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each  of  the  undersigned's   ownership  of  securities  of  Cypress
Bioscience,  Inc.,  and hereby  affirm that such  Schedule 13D is being filed on
behalf of each of the undersigned.


                                       PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.,
                                       INC.

Dated:      August 19, 1999
            New York, NY               By /s/ Lindsay A. Rosenwald. M.D.
                                         ------------------------------------
                                             Lindsay A. Rosenwald, M.D.
                                             Chairman


                                       ARIES DOMESTIC FUND, L.P.
                                       By Paramount Capital Asset Management,
                                       Inc.
                                       General Partner

Dated:      August 19, 1999
            New York, NY               By /s/ Lindsay A. Rosenwald   M.D.
                                         -----------------------------------
                                             Lindsay A. Rosenwald, M.D.
                                             Chairman


                                       THE ARIES MASTER FUND
                                       By Paramount Capital Asset Management,
                                       Inc.
                                       Investment Manager

Dated:      August 19, 1999
            New York, NY               By /s/ Lindsay A. Rosenwald, M.D.
                                         ----------------------------------
                                             Lindsay A. Rosenwald, M.D.
                                             Chairman

Dated:      August 19, 1999
            New York, NY              By  /s/ Lindsay A. Rosenwald, M.D.
                                        -----------------------------------
                                          Lindsay A. Rosenwald, M.D.

<PAGE>

                                    EXHIBIT B

         The name and principal occupation or employment, which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                               PRINCIPAL OCCUPATION
         NAME                                      OR EMPLOYMENT
         ----                                      -------------

Lindsay A. Rosenwald, M.D.            Chairman of the Board of Paramount Capital
                                      Asset Management,  Inc., Paramount Capital
                                      Investments,  LLC and  Paramount  Capital,
                                      Inc.

Mark C. Rogers, M.D.                  President  of  Paramount   Capital   Asset
                                      Management,    Inc.,   Paramount   Capital
                                      Investments,  LLC and  Paramount  Capital,
                                      Inc.

Peter Morgan Kash                     Director  of   Paramount   Capital   Asset
                                      Management,    Inc.,    Senior    Managing
                                      Director, Paramount Capital, Inc.

Dr. Yuichi Iwaki                      Director  of   Paramount   Capital   Asset
                                      Management, Inc., Professor, University of
                                      Southern California School of Medicine


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.

<PAGE>

                                    EXHIBIT C

         The name and principal  occupation or  employment,  which is located at
787  Seventh  Avenue,  48th Floor,  New York,  New York,  10019,  of the General
Partner of Aries Domestic is as follows:

                                                    PRINCIPAL OCCUPATION
         NAME                                           OR EMPLOYMENT
         ----                                           -------------

Paramount Capital Asset Management,         General Partner; Investment Manager
Inc.

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


<PAGE>

                                    EXHIBIT D

         The name and principal occupation or employment, which in each instance
is with The Aries Master Fund ("Aries Fund") located at 787 Seventh Avenue, 48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                         PRINCIPAL OCCUPATION
         NAME                                                OR EMPLOYMENT
         ----                                                -------------

Paramount Capital Asset Management, Inc.                  Investment Manager

MeesPierson (Cayman) Management Limited                   Administrator

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years  prior to the date  hereof,  neither of the above
persons  (to the  best of Aries  Fund's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.




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