CYPRESS BIOSCIENCE INC
SC 13D/A, 1999-03-19
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
Previous: LINCOLN NATIONAL MANAGED FUND INC, 24F-2NT, 1999-03-19
Next: NORTHBROOK VARIABLE ANNUITY ACCOUNT, 497, 1999-03-19




                        SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C.  20549

                                   SCHEDULE 13D
                                 (Amendment No.2)

                     Under the Securities Exchange Act of 1934


                             Cypress Bioscience, Inc.    
                        ---------------------------------
                                 (Name of Issuer)


                      Common Stock, par value $.02 per share
                      --------------------------------------
                          (Title of Class of Securities)

                                   2 232674 101            
                          ----------------------------
                                  (CUSIP Number)


                     Paramount Capital Asset Management, Inc.
                          c/o Lindsay A. Rosenwald, M.D.
                                787 Seventh Avenue
                                New York, NY 10019
                                  (212) 554-4300
                                  with a copy to:

                                 Michael S. Weiss
                     Paramount Capital Asset Management, Inc.
                                787 Seventh Avenue
                                New York, NY 10019
                                  (212) 554-4372
                               -------------------

      (Name, Address and Telephone Number of Person Authorized to Receive
                          Notices and Communications)


                                February 9, 1999         
                          -----------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:
                                                                             [ ]



<PAGE>

- ----------------------                                   
CUSIP No. 2 232674 101             13D                   
- ----------------------                                   

- --------------------------------------------------------------------------------

1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS*
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)
                                                                      [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

- --------------------------------------------------------------------------------
             NUMBER OF              7       SOLE VOTING POWER
              SHARES                        None
                                    --------------------------------------------
           BENEFICIALLY             8       SHARED VOTING POWER
             OWNED BY                       9,576,635
                                    --------------------------------------------
               EACH                 9       SOLE DISPOSITIVE POWER
             REPORTING                      None
                                    --------------------------------------------
              PERSON                10      SHARED DISPOSITIVE POWER
               WITH                         9,576,635 
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         9,576,635

- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         23.7%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*
         CO

- --------------------------------------------------------------------------------



                                        2

<PAGE>

- ----------------------                                   
CUSIP No. 2 232674 101             13D                   
- ----------------------                                   

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS* 
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
             NUMBER OF              7      SOLE VOTING POWER
              SHARES                       None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      2,883,500
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        2,883,400
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,883,400
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         7.1%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------



                                        3



<PAGE>

- ----------------------                                   
CUSIP No. 2 232674 101             13D                   
- ----------------------                                   

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        The Aries Master Fund
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS* 
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         Cayman Islands
- --------------------------------------------------------------------------------
             NUMBER OF              7      SOLE VOTING POWER
              SHARES                       None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      6,743,135
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        6,743,135
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         6,743,135
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         16.8%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON* 
         OO (see Item 2)
- --------------------------------------------------------------------------------




                                        4
<PAGE>

- ----------------------                                   
CUSIP No. 2 232674 101             13D                   
- ----------------------                                   

- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSONS
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a)[ ] (b)[ ]

- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        SOURCE OF FUNDS* 
         OO (see Item 3 below)
- --------------------------------------------------------------------------------
5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                            [ ]
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
             NUMBER OF              7      SOLE VOTING POWER
              SHARES                       None
                                    --------------------------------------------
           BENEFICIALLY             8      SHARED VOTING POWER
             OWNED BY                      9,576,635
                                    --------------------------------------------
               EACH                 9      SOLE DISPOSITIVE POWER
             REPORTING                     None
                                    --------------------------------------------
              PERSON                10     SHARED DISPOSITIVE POWER
               WITH                        9,576,635
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         9,576,635
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                      [ ]
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         23.7%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON* 
         IN
- --------------------------------------------------------------------------------



                                       5
<PAGE>

Item 1. Security and Issuer.
        -------------------

        (a)    Common Stock, $0.02 par value ("Shares")

               Cypress Bioscience, Inc. (the "Issuer")
               4350 Executive Drive, Suite 325
               San Diego, CA 92121
               (619) 452-2323

Item 2. Identity and Background.
        -----------------------

        Names of Persons Filing:

        (a)    This  statement  is filed on behalf of  Paramount  Capital  Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
               ("Aries  Domestic"),  Aries Master Fund, a Cayman Island exempted
               company  ("Aries  Fund") and  Lindsay A.  Rosenwald,  M.D.  ("Dr.
               Rosenwald" and collectively,  "Reporting Parties").  See attached
               Exhibit A which is a copy of their  agreement  in writing to file
               this statement on behalf of each of them.

        (b)    Paramount   Capital's,   Aries  Domestic's  and  Dr.  Rosenwald's
               business address is 787 Seventh Avenue, 48th Floor, New York, New
               York,   10019.  The  business  address  for  Aries  Fund  is  c/o
               MeesPierson  (Cayman)  Limited,  P.O. Box 2003,  British American
               Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

        (c)    Dr. Rosenwald is an investment banker,  venture capitalist,  fund
               manager  and  sole  shareholder  of  Paramount  Capital,   /1/  a
               Subchapter S  corporation  incorporated  in  Delaware.  Paramount
               Capital is the General Partner of Aries  Domestic,  /2/ a limited
               partnership  incorporated in Delaware.  Paramount  Capital is the
               investment  manager to Aries Fund, /3/ a Cayman Islands  exempted
               company.

        (d)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Fund
               and  their  respective  officers,  directors,  general  partners,
               investment managers,  or trustees have not, during the five years
               prior to the date hereof, been convicted in a criminal proceeding
               (excluding traffic violations or similar misdemeanors).

        (e)    Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Fund
               and  their  respective  officers,  directors,  general  partners,
               investment  managers,  or trustees have not been, during the five
               years prior to the date hereof,  parties to a civil proceeding of
               a judicial or administrative body of competent jurisdiction, as a
               result of which such  person  was or is  subject  to a  judgment,
               decree  or  final  order  enjoining  future   violations  of,  or
               prohibiting or mandating  activities subject to, Federal or State
               securities  laws or finding any  violation  with  respect to such
               laws.

        (f)    Dr. Rosenwald is a citizen of the United States.

Item 3. Source and Amount of Funds or Other Consideration.
        -------------------------------------------------

        Since  the date of  Amendment  No. 1 to  Schedule  13D  ("Amendment  No.
        1")which was filed on January 10, 1999,  Aries Domestic used its general
        funds to make certain open market  acquisitions of the securities of the
        Issuer and the Aries Fund

- -------------------------

               /1/    Please see  attached  Exhibit B indicating  the  executive
                      officers and directors of Paramount  Capital and providing
                      information  called for by Items 2-6 of this  statement as
                      to  said  officers  and  directors.  Exhibit  B is  herein
                      incorporated by reference.
               /2/    Please  see  attached  Exhibit C  indicating  the  general
                      partner  of  Aries  Domestic  and  the  general  partner's
                      executive officers and directors and providing information
                      called  for by  Items  2-6 of  this  statement  as to said
                      general  partners,  officers and  directors.  Exhibit C is
                      herein incorporated by reference.
               /3/    Please see attached  Exhibit D indicating  the  investment
                      manager  of the Aries  Fund and the  investment  manager's
                      executive officers and directors and providing information
                      called  for by  Items  2-6 of  this  statement  as to said
                      investment  manager and officers and directors.  Exhibit D
                      is herein incorporated by reference.




                                        6

<PAGE>

               used its general  funds to make certain open market  acquisitions
               of the  securities  of the Issuer.

                      The following purchases were made by Aries Domestic in the
                      open market since those reported in Amendment No. 1:

                      Date                         Amount        Purchase Price
                      ----                         ------        --------------
                      01/08/99                      2,600        2.938
                      01/11/99                      2,600        2.973
                      01/12/99                      2,600        3.048
                      01/13/99                      2,600        3.014
                      01/15/99                      2,600        3.443
                      01/20/99                      3,900        3.733
                      01/21/99                      1,300        3.750
                      01/22/99                      2,600        3.748
                      01/25/99                     33,800        2.891
                      01/26/99                     18,200        3.333
                      01/27/99                      1,300        3.438
                      01/28/99                      1,300        3.443
                      02/01/99                      5,200        3.188
                      02/02/99                      3,900        3.125
                      02/03/99                      5,200        3.083
                      02/04/99                      5,200        3.063
                      02/05/99                      5,200        3.083
                      02/05/99                     10,000        3.083
                      02/08/99                      5,200        3.022
                      02/09/99                      5,200        2.958
                      02/10/99                      5,200        2.959
                      02/11/99                      9,000        2.958
                      02/12/99                     10,000        3.045
                      02/16/99                      3,000        3.031
                      02/17/99                      3,000        2.925
                      02/18/99                      5,200        2.996
                      02/19/99                     10,500        3.041
                      02/22/99                      6,000        3.085
                      02/23/99                      3,000        2.991
                      02/24/99                      1,500        2.993
                      02/25/99                      6,000        3.087
                      02/26/99                     18,000        3.087
                      02/26/99                      3,000        3.031
                      03/01/99                      3,000        3.125
                      03/02/99                      6,000        3.110
                      03/03/99                      4,500        3.114
                      03/04/99                     17,500        3.088
                      03/05/99                     12,000        3.145
                      03/08/99                      9,000        3.312
                      03/09/99                      9,000        3.282
                      03/10/99                      6,000        3.248
                      03/11/99                      6,000        3.359
                      03/12/99                      6,000        3.350

                      The  following  purchases  were made by Aries Fund in the
                      open  market since those reported in Amedment No. 1:

                      Date                         Amount        Purchase Price
                      ----                         ------        --------------
                      01/08/99                      7,400        2.938
                      01/11/99                      7,400        2.973
                      01/12/99                      7,400        3.048
                      01/13/99                      7,400        3.014
                      01/15/99                      7,400        3.443
                      01/20/99                     11,100        3.733
                      01/21/99                      3,700        3.750
                      01/22/99                      7,400        3.748
                      01/25/99                     96,200        2.891
                      01/26/99                     51,800        3.333
                      01/27/99                      3,700        3.438
                      01/28/99                      3,700        3.443
                      02/01/99                     14,800        3.188
                      02/02/99                     11,100        3.125
                      02/03/99                     14,800        3.083
                      02/04/99                     14,800        3.063
                      02/05/99                     14,800        3.083
                      02/05/99                     14,800        3.083
                      02/08/99                     14,800        3.022
                      02/09/99                     14,800        2.958
                      02/10/99                     14,800        2.959
                      02/11/99                     21,000        2.958
                      02/12/99                     20,000        3.045
                      02/16/99                      7,000        3.031
                      02/17/99                     14,800        2.925




                                       7
<PAGE>

                      02/18/99                     14,800        2.996
                      02/18/99                      5,000        2.996
                      02/19/99                     24,500        3.041
                      02/22/99                     14,000        3.085
                      02/23/99                      7,000        2.991
                      02/24/99                      8,500        2.993
                      02/25/99                     14,000        3.087
                      02/26/99                     42,000        3.087
                      02/26/99                      7,000        3.031
                      03/01/99                      7,000        3.125
                      03/02/99                     14,000        3.110
                      03/03/99                     10,500        3.114
                      03/04/99                      7,500        3.088
                      03/05/99                     28,000        3.145
                      03/08/99                     21,000        3.312
                      03/09/99                     21,000        3.282
                      03/10/99                     14,000        3.248
                      03/11/99                     14,000        3.359
                      03/12/99                     14,000        3.350

Item 4. Purpose of Transaction.
        ----------------------

               The  Reporting  Parties  acquired  shares of Common  Stock of the
        Issuer as an investment in the Issuer.

               Although the Reporting Parties have not formulated any definitive
        plans,  they may from time to time acquire,  or dispose of, Common Stock
        and/or  other  securities  of  the  Issuer  if and  when  they  deem  it
        appropriate.  The Reporting Parties may formulate other purposes,  plans
        or  proposals  relating to any of such  securities  of the Issuer to the
        extent  deemed  advisable  in light  of  market  conditions,  investment
        policies and other factors.

               Except as indicated in this Schedule  13D, the Reporting  Parties
        currently  have no plans or proposals  that relate to or would result in
        any of the matters  described in subparagraphs (a) through (j) of Item 4
        of Schedule 13D.

Item 5. Interest in Securities of the Issuer.
        ------------------------------------

               (a)    As of March 15, 1999, Dr. Rosenwald and Paramount Capital,
                      through  acquisition  of the  shares by the Aries Fund and
                      Aries Domestic,  beneficially  owned  9,576,635  shares or
                      23.7% of the Issuer's  securities  and Aries  Domestic and
                      the Aries Fund beneficially owned as follows:

                                                          Amount Owned
                                                          ------------
                      Aries Domestic                      2,833,500 Shares
                      Aries Fund                          6,743,135 Shares

               (b)    Dr.  Rosenwald  and  Paramount  Capital share the power to
                      vote or to direct  the vote,  to  dispose or to direct the
                      disposition  of  those  shares  owned  by  each  of  Aries
                      Domestic and Aries Fund.

               (c)    Other than certain open market purchases set forth in Item
                      3,  the   Reporting   Parties  have  not  engaged  in  any
                      transactions  in the Common Stock of the Issuer during the
                      past 60 days.




                                       8

<PAGE>

               (d) & (e)     Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships
        with respect to Securities of the Issuer
        --------------------------------------------------------

               Paramount Capital is the investment manager of the Aries Fund and
        the General  Partner of Aries  Domestic and in such  capacities  has the
        authority  to  make  certain  investment  decisions  on  behalf  of such
        entities,  including decisions relating to the securities of the Issuer.
        In connection with its investment  management duties,  Paramount Capital
        receives  certain  management fees and performance  allocations from the
        Aries Fund and Aries Domestic.  Dr. Rosenwald is the sole shareholder of
        Paramount Capital.  Except as indicated in this 13D and exhibits,  there
        is no contract,  arrangement, under standing or relationship between the
        Reporting  Parties and any other person,  with respect to any securities
        of the Issuer.

Item 7. Material to be Filed as Exhibits:
        --------------------------------

Exhibit A -    Copy of an Agreement  between Dr. Rosenwald,  Paramount  Capital,
               Aries  Domestic and Aries Fund to file this Statement on Schedule
               13D on behalf of each of them.

Exhibit B -    List of executive officers and directors of Paramount Capital and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit C -    List of executive  officers and  directors of Aries  Domestic and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit D -    List of  executive  officers  and  directors  of  Aries  Fund and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.





                                       9

<PAGE>

                                   SIGNATURES
                                   ----------


               After  reasonable  inquiry  and to the best of my  knowledge  and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


                                   PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:         March 16, 1999
               New York, NY        By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       Chairman


                                   ARIES DOMESTIC FUND
                                   By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:         March 16, 1999
               New York, NY        By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       Chairman


                                   THE ARIES MASTER FUND
                                   By Paramount Capital Asset Management, Inc.
                                   Investment Manager

Dated:         March 16, 1999
               New York, NY        By /s/ Lindsay A. Rosenwald, M.D. 
                                      ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       Chairman


Dated:         March 16, 1999
               New York, NY        By  /s/ Lindsay A. Rosenwald, M.D.  
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.












                                       10

<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D



               The  undersigned  hereby agrees to jointly  prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each  of  the  undersigned's   ownership  of  securities  of  Cypress
Bioscience,  Inc.,  and hereby  affirm that such  Schedule 13D is being filed on
behalf of each of the undersigned.

                                   PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:         March 16, 1999
               New York, NY        By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       Chairman


                                   ARIES DOMESTIC FUND
                                   By Paramount Capital Asset Management, Inc.
                                        General Partner

Dated:         March 16, 1999
               New York, NY        By /s/ Lindsay A. Rosenwald, M.D.
                                      ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       Chairman


                                   THE ARIES MASTER FUND
                                   By Paramount Capital Asset Management, Inc.
                                   Investment Manager

Dated:         March 16, 1999
               New York, NY        By /s/ Lindsay A. Rosenwald, M.D. 
                                      ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       Chairman


Dated:         March 16, 1999
               New York, NY        By  /s/ Lindsay A. Rosenwald, M.D.  
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.





                                       11

<PAGE>

                                    EXHIBIT B

        The name and principal occupation or employment,  which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

<TABLE>
<CAPTION>

                                                                PRINCIPAL OCCUPATION
        NAME                                                        OR EMPLOYMENT
        ----                                                        -------------
<S>                                     <C>    

Lindsay A. Rosenwald, M.D.                  Chairman of the Board of Paramount Capital Asset Management, Inc.,
                                            Paramount Capital Investments, LLC and Paramount Capital, Inc.

Mark C. Rogers, M.D.                        President of Paramount Capital Asset Management, Inc., Paramount Capital
                                            Investments, LLC and Paramount Capital, Inc.

Peter Morgan Kash                           Director of Paramount Capital Asset Management, Inc., Senior Managing
                                            Director, Paramount Capital, Inc.

Dr. Yuichi Iwaki                            Director of Paramount Capital Asset Management, Inc., Professor, Univer
                                            sity of Southern California School of Medicine

</TABLE>


Item 2.

        During  the  five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.









                                       12

<PAGE>

                                    EXHIBIT C

        The name and principal occupation or employment, which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic is as follows:

<TABLE>
<CAPTION>

                                                                 PRINCIPAL OCCUPATION
        NAME                                                        OR EMPLOYMENT
        ----                                                        -------------
<S>                                               <C>    

Paramount Capital Asset Management, Inc.           General Partner; Investment Manager

</TABLE>

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five years prior to the date hereof, the above person (to the
best of  Aries  Domestic's  knowledge)  has not  been  convicted  in a  criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.





                                       13

<PAGE>

                                    EXHIBIT D

        The name and principal occupation or employment,  which in each instance
is with The Aries Master Fund ("Aries Fund") located at 787 Seventh Avenue, 48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:


                                                         PRINCIPAL OCCUPATION
        NAME                                                OR EMPLOYMENT
        ----                                                -------------

Paramount Capital Asset Management, Inc.                  Investment Manager

MeesPierson (Cayman) Management Limited                   Administrator

        Exhibit B is hereby incorporated by reference.

Item 2.

        During the five  years  prior to the date  hereof,  neither of the above
persons  (to the  best of Aries  Fund's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

        Please refer to Items 3-6 herein reporting the beneficial ownership.



                                       14



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission