SYNBIOTICS CORP
S-3/A, 1998-09-24
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
Previous: S&T BANCORP INC, 8-K, 1998-09-24
Next: PUTNAM NEW YORK TAX EXEMPT INCOME TRUST, 497, 1998-09-24



<PAGE>
 
    
As filed with the Securities and Exchange Commission on September 24, 1998      
    
Registration No. 333-63341      


                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                        ------------------------------
                       PRE-EFFECTIVE AMENDMENT NO. 1 TO       
                                   FORM S-3
                            REGISTRATION STATEMENT
                                     Under
                          THE SECURITIES ACT OF 1933
                        ------------------------------
                            SYNBIOTICS CORPORATION
            (Exact name of Registrant as specified in its charter)

             California                                     95-3737816
       (State or other juris-                            (I.R.S. Employer
         diction of incorpo-                            Identification No.)
       ration or organization)

                               11011 Via Frontera
                          San Diego, California 92127
                                 (619) 451-3771
              (Address, including zip code, and telephone number,
       including area code, of registrant's principal executive offices)

                                Kenneth M. Cohen
                     President and Chief Executive Officer
                             SYNBIOTICS CORPORATION
                11011 Via Frontera, San Diego, California 92127
                                 (619) 451-3771
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)

                         ------------------------------
                                    Copy to:

                            Hayden J. Trubitt, Esq.
                              Joel S. Smith, Esq.
                        BROBECK, PHLEGER & HARRISON LLP
                         550 West C Street, Suite 1300
                          San Diego, California 92101
                         ------------------------------

        Approximate date of commencement of proposed sale to the public:
   From time to time after the effective date of this Registration Statement.

If the only securities being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box.  [_]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box.  [X]

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering.  [_]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering.  [_]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box.  [_]

The Registrant hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the Registrant shall file
a further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a),
may determine.
<PAGE>
 
                                 333,333 Shares
                             SYNBIOTICS CORPORATION
                                  Common Stock

This Prospectus relates to the public offering, which is not being underwritten,
of 333,333 shares of Common Stock, no par value per share (the "Shares"), of
Synbiotics Corporation ("Synbiotics" or the "Company").  All of these Shares are
held and may be offered by Barnes-Jewish Hospital Foundation, a shareholder of
the Company, which received such Shares pursuant to an exemption from the
registration requirements of the Securities Act of 1933, as amended (the
"Securities Act") provided by Section 4(2) thereof, in connection with
Synbiotics' settlement in July 1998 of a patent infringement lawsuit brought by
Barnes-Jewish Hospital.  The settlement agreement contemplates the possible
transfer of some or all of the Shares by Barnes-Jewish Hospital Foundation to
Gary J. Weil and/or Senniger, Powers, Leavitt & Roedel.  As used herein, the
term "Selling Shareholder" refers (collectively and in the singular, although
each has the power to act independently of the others) to Barnes-Jewish Hospital
Foundation and also, as applicable, Gary J. Weil and Senniger, Powers, Leavitt &
Roedel.  As part of the settlement, Synbiotics issued the Shares to the Selling
Shareholder and agreed to register them.

The sale of the Shares may be effected by the Selling Shareholder from time to
time in transactions in the over-the-counter market, in negotiated transactions
or a combination of such methods of sale, at fixed prices which may be changed,
at market prices prevailing at the time of sale, at prices related to prevailing
market prices or at negotiated prices.  The Selling Shareholder may effect such
transactions by selling the Shares to or through broker-dealers, and such
broker-dealers may receive compensation in the form of discounts, concession or
commission from the Selling Shareholder and/or the purchasers of the Shares for
whom such broker-dealers may act as agents or to whom they may sell as
principals or both (which compensation as to a particular broker-dealer might be
in excess of customary commissions).  It is not possible at the present time to
determine the price to the public in any sale of the Shares by the Selling
Shareholder and the Selling Shareholder reserves the right to accept or reject,
in whole or in part, any proposed purchase of Shares.  Accordingly, the public
offering price and the amount of any applicable underwriting discounts and
commissions will be determined at the time of such sale by the Selling
Shareholder.  Substantially all costs, expenses and fees incurred in connection
with the registration of the Shares, estimated to be approximately $12,000, are
being borne by the Company, but all selling and other expenses incurred by the
Selling Shareholder will be borne by the Selling Shareholder.  See "Plan of
Distribution."

None of the proceeds from the sale of the Shares by the Selling Shareholder will
be received by the Company.

Synbiotics Common Stock is traded on the Nasdaq National Market ("Nasdaq
National Market") under the symbol "SBIO".  On September 3, 1998, the closing
sale price of Synbiotics Common Stock as reported on the Nasdaq National Market
was $2.50 per share.

The Selling Shareholder and any broker-dealers, agents or underwriters that
participate with the Selling Shareholder in the distribution of Shares may be
deemed to be "underwriters" within the meaning of Section 2(11) of the
Securities Act, and any commissions received by them and any profit on the
resale of the Shares purchased by them may be deemed to be underwriting
commissions or discounts under the Securities Act.  See "Plan of Distribution"
for a description of indemnification arrangements.

                                _______________

THE COMMON STOCK OFFERED HEREBY INVOLVES A HIGH DEGREE OF RISK.  SEE "RISK
FACTORS" ON PAGE 3 FOR INFORMATION THAT SHOULD BE CONSIDERED BY PROSPECTIVE
INVESTORS.
                                _______________

THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE SECURITIES
AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS.  ANY REPRESENTATION TO THE CONTRARY IS
A CRIMINAL OFFENSE.

                                _______________
                 
             The date of this Prospectus is September 25, 1998.      
<PAGE>
 
                            SYNBIOTICS CORPORATION

                               TABLE OF CONTENTS


                                                                           
                                                                     
<TABLE>
<CAPTION>
                                                                      Page 
                                                                      ---- 
<S>                                                                   <C>
Available Information.................................................   2

Information Incorporated by Reference.................................   2

The Company...........................................................   3

Forward-Looking Statements............................................   3

Risk Factors..........................................................   3

Use of Proceeds.......................................................   7

Selling Shareholder...................................................   7

Plan of Distribution..................................................   8

Legal Matters.........................................................   9

Indemnification.......................................................   9
</TABLE>
<PAGE>
 
No person has been authorized to give any information or to make any
representations other than those contained in this Prospectus in connection with
the offering made hereby, and if given or made, such information or
representations must not be relied upon as having been authorized by the
Company, the Selling Shareholder or by any other person. Neither the delivery of
this Prospectus nor any sale made hereunder shall, under any circumstances,
create any implication that information herein is correct as of any time
subsequent to the date hereof. This Prospectus does not constitute an offer to
sell or a solicitation of an offer to buy the Shares to any person or by anyone
in any jurisdiction in which such offer or solicitation may not lawfully be 
made.

                             AVAILABLE INFORMATION

Synbiotics is subject to the reporting requirements of the Securities Exchange
Act of 1934, as amended (the "Exchange Act"), as applicable to small business
issuers such as Synbiotics, and in accordance therewith files annual and
quarterly reports, proxy statements and other information with the Securities
and Exchange Commission (the "Commission").  Such reports, proxy statements and
other information may be inspected at the Commission's Public Reference Section,
Room 1024, 450 Fifth Street, N.W., Washington, D.C. 20549, as well as at the
Commission's regional offices at 7 World Trade Center, 13th Floor, New York, New
York 10048; and at Northwest Atrium Center, 500 West Madison Street, Room 1400,
Chicago, Illinois 60661-2511.  Copies of such material can also be obtained at
prescribed rates at the Public Reference Section of the Commission at 450 Fifth
Street, N.W., Washington, D.C. 20549.  The Commission maintains a World Wide Web
site on the Internet at http://www.sec.gov that contains reports, proxy and
information statements and other information regarding registrants that file
electronically with the Commission.  The Common Stock of the Company is traded
on the Nasdaq National Market and such reports, proxy and information statements
and other information concerning the Company may be inspected at the offices of
the National Association of Securities Dealers, Inc., 9513 Key West Avenue,
Rockville, Maryland 20850.

This Prospectus constitutes a part of a Registration Statement on Form S-3
(herein, together with all amendments and exhibits, referred to as the
"Registration Statement") filed by the Company with the Commission under the
Securities Act.  This Prospectus does not contain all of the information set
forth in the Registration Statement, certain parts of which are omitted in
accordance with the rules and regulations of the Commission.  For further
information with respect to the Company and the shares of Common Stock offered
hereby, reference is hereby made to the Registration Statement.  The
Registration Statement may be inspected at the public reference facilities
maintained by the Commission at the addresses set forth in the preceding
paragraph.  Statements contained herein concerning any document filed as an
exhibit are not necessarily complete and, in each instance, reference is made to
the copy of such document filed as an exhibit to the Registration Statement.
Each such statement is qualified in its entirety by such reference.

                     INFORMATION INCORPORATED BY REFERENCE

The following documents filed by the Company with the Commission (Commission
File No. 0-11303) are hereby incorporated by reference in this Prospectus:

(1)  The Annual Report of the Company on Form 10-KSB for the fiscal year ended
     December 31, 1997;

(2)  The Quarterly Reports of the Company on Form 10-QSB for the fiscal quarters
     ended March 31, 1998 and June 30, 1998;

(3)  The Current Report on Form 8-K filed March 23, 1998 for an event of March
     6, 1998; and

(4)  The Company's Registration Statement on Form 8-A filed with the Commission
     on November 14, 1983 and declared effective on January 13, 1984 pursuant to
     Section 12 of the Exchange Act, in which there is described the terms,
     rights and provisions applicable to the Company's Common Stock.

                                      -2-
<PAGE>
 
All reports and other documents subsequently filed by the Company pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this
Prospectus and prior to the termination of this Offering shall be deemed to be
incorporated by reference herein and to be a part hereof from the date of filing
of such reports and documents.  Any statement incorporated herein shall be
deemed to be modified or superseded for purposes of this Prospectus to the
extent that a statement contained herein or in any other subsequently filed
document which also is or is deemed to be incorporated by reference herein
modifies or supersedes such statement.  Any statement so modified or superseded
shall not be deemed, except as so modified or superseded, to constitute a part
of this Prospectus.

The Company will provide without charge to each person to whom this Prospectus
is delivered, upon written or oral request of such person, a copy of any or all
of the foregoing documents incorporated herein by reference (other than exhibits
to such documents, unless such exhibits are specifically incorporated by
reference into such document).  Requests for such documents should be submitted
in writing to the Secretary, at Synbiotics Corporation, 11011 Via Frontera, San
Diego, California 92127 or by telephone at (619) 451-3771.

                                  THE COMPANY

Synbiotics Corporation is a leading provider of rapid diagnostic and laboratory
diagnostic products for the animal health care industry, including canine
reproduction diagnostic products and services, PennHIP(R) (a diagnostic test for
canine hip dysplasia) and nutritional supplements marketed to breeders and
owners of purebred dogs and their veterinarians.  The Company also markets a
line of vaccine products.  Synbiotics was founded in 1982 to research and
develop monoclonal antibody-based diagnostic and therapeutic products.  In the
early years, the Company, like most biotechnology firms, was focused on
developing therapeutics for human diseases.  The high cost of human drug
development, coupled with the lengthy FDA approval process, motivated Synbiotics
to begin commercializing its technology through the less restrictive animal
health care market.  Synbiotics is one of a small number of companies that
focuses exclusively on animal health and is the second largest provider of
diagnostic products to the animal health market.

The Company's principal executive offices are located at 11011 Via Frontera, San
Diego, California 92127, and its telephone number is (619) 451-3771.

                           FORWARD-LOOKING STATEMENTS

This Prospectus and the documents incorporated herein by reference contain
forward-looking statements that are based on current expectations, estimates and
projections about the Company's industry, management's beliefs, and assumptions
made by management.  Words such as "anticipates," "expects," "intends," "plans,"
"believes," "seeks," "estimates," and variations of such words and similar
expressions are intended to identify such forward-looking statements.  These
statements are not guarantees of future performance and are subject to certain
risks, uncertainties and assumptions that are difficult to predict; therefore,
actual results may differ materially from those expressed or forecasted in any
such forward-looking statements.  Such risks and uncertainties include those
noted in "Risk Factors" below and in the documents incorporated herein by
reference.  The Company undertakes no obligation to update publicly any forward-
looking statements, whether as a result of new information, future events or
otherwise.

                                  RISK FACTORS

An investment in the Shares involves a high degree of risk.  In addition to the
other information contained in this Prospectus, the following risk factors
should be considered carefully in evaluating an investment in the Shares.

No Assurance that Acquired Businesses Can Be Successfully Combined
- ------------------------------------------------------------------

There can be no assurance that the anticipated benefits of the acquisition of
Prisma Acquisition Corp. (completed in March 1998), the 1997 acquisition of the
veterinary diagnostics business of Rhone Merieux S.A.S. (now conducted

                                      -3-
<PAGE>
 
in the Company's European subsidiary ("SBIO-E")), the 1996 acquisition of the
business of International Canine Genetics, Inc. ("ICG"),  or any other future
acquisitions (collectively, the "Acquired Business") will be realized.
Acquisitions of businesses involve numerous risks, including difficulties in the
assimilation of the operations, technologies and products of the Acquired
Business, introduction of different distribution channels, potentially dilutive
issuances of equity and/or increases in leverage and risk resulting from
issuances of debt securities, the need to establish internally operating
functions which had been previously provided pre-acquisition by a corporate
parent, accounting charges, operating companies in different geographic
locations with different cultures, the potential loss of key employees of the
Acquired Business, the diversion of management's attention from other business
concerns and the risks of entering markets in which Synbiotics has no or limited
direct prior experience.  In addition, there can be no assurance that the
acquisitions will not have a material adverse effect upon Synbiotics' business,
results of operations or financial condition, particularly in the quarters
immediately following the consummation of the acquisition due to operational
disruptions, unexpected expenses and accounting charges which may be associated
with the integration of the Acquired Business and Synbiotics, as well as
operating and development expenses inherent in the Acquired Business itself as
opposed to integration of the Acquired Business.

Competition
- -----------

Competition in the animal health care industry is intense.  Many competitors,
such as Pfizer Animal Health, Merial Animal Health (the successor to Rhone
Merieux), Schering-Plough and IDEXX Laboratories, have substantially greater
financial, manufacturing, marketing and product research resources than the
Company.  Large companies in particular have extensive expertise in conducting
pre-clinical and clinical testing of new products and in obtaining the necessary
regulatory approvals to market products.  Competition is based on test
sensitivity, accuracy and speed; product price; and similar factors.  IDEXX
Laboratories requires its distributors not to carry the products of competitors
such as Synbiotics.  There can be no assurance that such competition will not
adversely affect Synbiotics' results of operations or ability to maintain or
increase sales and market share.

History of Operating Losses; Accumulated Deficit
- ------------------------------------------------

Although the Company's operations were profitable for the years ended December
31, 1997 and 1996, the Company has had a history of losses.  Synbiotics has
incurred a consolidated accumulated deficit of $10,747,000 at June 30, 1998,
even after the release in 1996 of a $7,158,000 valuation allowance related to
deferred tax assets.  There can be no assurance that Synbiotics can generate
sufficient revenue to sustain profitability.

Reliance on Third Party Manufacturers
- -------------------------------------

Certain of Synbiotics' products (including its ICT Gold(TM), VetRED(R) and
WITNESS(R) diagnostic kits and all of its vaccines) are, and certain
anticipated new products are expected to be, manufactured by third parties under
the terms of distribution and/or manufacturing agreements.  The ICT Gold(TM),
VetRED(R) and WITNESS(R) products and feline leukemia virus vaccine are
licensed to Synbiotics by their respective outside manufacturers.  In the event
that these third parties are unable (due to operational, licensing, financial or
other reasons) to supply Synbiotics with sufficient finished products,
Synbiotics would suffer significant disruption of its business.  Synbiotics has
the right, under certain circumstances, pursuant to the agreements to use
alternate manufacturing sources.  In some circumstances, however, the Company
would lack such a right.

If Synbiotics should encounter delays or difficulties in its relationships with
manufacturers, the resulting problems could have a material adverse effect on
Synbiotics.  In fact, a majority of the Company's vaccine products (exclusive of
its feline leukemia vaccine products) are manufactured using bulk antigen fluids
that have been supplied by a third party.  The supply agreement has expired and
the Company is currently seeking a replacement supplier for these fluids.  The
Company believes it has adequate levels of these bulk fluids to meet its
manufacturing requirements through the third quarter of 1998.  In the event that
the Company is unable to locate a replacement supplier, sales of the Company's
private label vaccine products, beginning in the fourth quarter of 1998, will be
materially adversely affected.

                                      -4-
<PAGE>
 
Sales and Marketing
- -------------------

The Company's product distribution strategy results in a large percentage of
sales being to only a few customers.  During the year ended December 31, 1997,
sales to two distributors totalled 40% of the Company's net sales.  In addition,
SBIO-E's small animal products are presently sold through distributors, while
its large animal products are sold directly to laboratories.  There can be no
assurance that Synbiotics will be able to establish an adequate sales and
marketing capability in any or all targeted markets or that it will be
successful in gaining market acceptance of its products.  To the extent
Synbiotics enters into distributor arrangements, any revenues received by
Synbiotics will be dependent on the efforts of third parties and there can be no
assurance that such efforts will be successful.  IDEXX Laboratories' requirement
that its distributors not carry the products of competitors such as Synbiotics
has induced certain distributors to stop doing business with Synbiotics in order
to carry IDEXX products instead.  In addition, Synbiotics' sales of products, on
a private-label basis, toward the over-the-counter market may cause an adverse
reaction among Synbiotics' regular distributor and veterinarian customers.

Attraction of Key Employees
- ---------------------------

The success of Synbiotics is highly dependent, in part, on its ability to retain
highly qualified personnel, including senior management and scientific
personnel.  Competition for such personnel is intense and the inability to
retain additional key employees or the loss of one or more current key employees
could adversely affect Synbiotics.  Although Synbiotics has been successful in
retaining required personnel to date, there can be no assurance that Synbiotics
will be successful in the future.

Reliance on New and Recent Products
- -----------------------------------

Synbiotics relies to a significant extent on new and recently developed
products, and expects that it will need to continue to introduce new products to
be successful in the future.  There can be no assurance that Synbiotics will
obtain and maintain market acceptance of its products.  With respect to future
products, there can be no assurance that such products will meet applicable
regulatory standards, be capable of being produced in commercial quantities at
acceptable cost or be successfully commercialized.

There can be no assurance that new products can be manufactured at a cost or in
quantities necessary to make them commercially viable.  If Synbiotics were
unable to produce internally, or to contract for, a sufficient supply of its new
products on acceptable terms, or if it should encounter delays or difficulties
in its relationships with manufacturers, the introduction of new products would
be delayed, which could have a material adverse effect on  Synbiotics.

Future Capital Needs; Uncertainty of Additional Funding
- -------------------------------------------------------

The development and commercialization of Synbiotics' products requires
substantial funds.  Synbiotics' future capital requirements will depend on many
factors, including cash flow from operations, the need to finance further
acquisitions, if any, continued scientific progress in its products and
development programs, the cost of manufacturing scale-up, the costs involved in
preparing, filing, prosecuting, maintaining and enforcing patent claims, the
cost involved in patent infringement litigation, competing technological and
market developments, and the cost of establishing effective sales and marketing
arrangements.  Synbiotics anticipates that its existing, available cash, cash
equivalents and short-term investments will be adequate to satisfy its current
capital requirements and fund its current operations, although any large
acquisition would require additional capital resources.  There can be no
assurance that additional financing, if required, will be available on
acceptable terms or at all.  If additional funds are raised by issuing equity
securities, further dilution to then existing shareholders may result. Debt
financing would result in increased leverage and risk.

In July 1997, the Company obtained $15,000,000 of debt financing from Banque
Paribas, of which $11,493,000 was used in connection with the acquisition of
SBIO-E.  The $15,000,000 included a $5,000,000 revolving line of credit.

                                      -5-
<PAGE>
 
However, draws on the line of credit are subject to certain requirements and can
be used only for certain purposes.  Additionally, Banque Paribas requires the
Company to maintain certain financial ratios and levels of tangible net worth
and also restricts the Company's ability to pay dividends and make loans,
capital expenditures or investments without the Bank's consent.

If adequate funds are not available, Synbiotics may be required, among other
things, to delay, scale back or eliminate one or more of its research and
development programs or seek to obtain funds through arrangements with
collaborative partners or others even if the arrangements would require
Synbiotics to relinquish certain rights to certain of its technologies, product
candidates or products that Synbiotics would not otherwise relinquish.

Seasonality
- -----------

Synbiotics has experienced some seasonality in its business, with sales highest
in December to April, the time period in which distributors purchase canine
heartworm diagnostic products to sell to veterinarians for the heartworm season.
This seasonality may be somewhat reduced by the acquisition of SBIO-E, which is
relatively less seasonal.  There can be no assurance that such seasonality will
not have a material adverse impact on Synbiotics' operations.

Patents and Proprietary Technology
- ----------------------------------

Synbiotics generally has sought and will continue to seek to protect its
interests by treating its particular variations in the production of monoclonal
antibodies as trade secrets.  Synbiotics also has pursued and intends to
continue aggressively to pursue protection for new products, new methodological
concepts, and compositions of matter through the use of patents where
obtainable.  At present, Synbiotics has been granted eleven U.S. patents and has
three U.S. patents pending.

There can be no assurance that Synbiotics will be issued any additional patents
or that, if any patents are issued, they will provide Synbiotics with
significant protection or will not be challenged.  Even if such patents are
enforceable, Synbiotics anticipates that any attempt to enforce its patents
would be time consuming and costly.  Moreover, the laws of some foreign
countries do not protect Synbiotics' proprietary rights in its products to the
same extent as do the laws of the United States.

The patent positions of biotechnology companies, including Synbiotics, are
uncertain and involve complex legal and factual issues.  Additionally, the
coverage claimed in a patent application can be significantly reduced before the
patent is issued.  As a consequence, there can be no assurance that any of
Synbiotics' future patent applications will result in the issuance of patents
or, if any patents issue, that they will provide significant proprietary
protection or will not be circumvented or invalidated.  Because patent
applications in the United States are maintained in secrecy until patents issue
and publication of discoveries in the scientific or patent literature often lag
behind actual discoveries, Synbiotics cannot be certain that it was the first
inventor of inventions covered by its pending patent applications or that it was
the first to file patent applications for such inventions.  Moreover, Synbiotics
may have to participate in interference proceedings declared by the U.S. Patent
and Trademark Office to determine priority of invention that could result in
substantial cost to Synbiotics, even if the eventual outcome is favorable to
Synbiotics.  There can be no assurance that Synbiotics' patents would be held
valid by a court of competent jurisdiction.  An adverse outcome of any patent
litigation could subject Synbiotics to significant liabilities to third parties,
require disputed rights to be licensed from or to third parties or require
Synbiotics to cease using the technology in dispute.  In 1997, a patentholder
(Barnes-Jewish Hospital) filed a lawsuit asserting that the Company's key canine
heartworm diagnostic tests infringe its patent.  The lawsuit was settled in July
1998.

There can be no assurance that other third parties will not assert other
infringement claims against Synbiotics in the future or that any such assertions
will not result in costly litigation or require Synbiotics to obtain a license
to intellectual property rights of such parties.  There can be no assurance that
any such licenses would be available on terms acceptable to Synbiotics, if at
all.  Furthermore, parties making such claims may be able to obtain injunctive
or other equitable relief that could effectively block Synbiotics' ability to
further develop, or commercialize, its

                                      -6-
<PAGE>
 
products in the United States and abroad.  Such claims could result in the award
of substantial damages.  Defense of any lawsuit or failure to obtain any such
license could have a material adverse effect on Synbiotics.  Finally,
litigation, regardless of outcome, could result in substantial cost to, and a
diversion of efforts by, Synbiotics.

Government Regulation
- ---------------------

Synbiotics' business is subject to substantial regulation by the United States
government (see Item 1 - Business--Government Regulation of the Company's Annual
Report on Form 10-KSB for the year ended December 31, 1997, which is hereby
incorporated by reference).  In addition, Synbiotics' operations may be subject
to future legislation and/or rules issued by domestic or foreign governmental
agencies with regulatory authority relating to Synbiotics' business.  There can
be no assurance that Synbiotics will be found in compliance with any of the
various regulations to which it is subject.

For marketing outside the United States, Synbiotics will be subject to foreign
regulatory requirements in such foreign jurisdictions, which vary widely from
country to country.  There can be no assurance that Synbiotics will meet and
sustain compliance with any such requirements.

Product Liability and Insurance
- -------------------------------

The design, development and manufacture of Synbiotics' products involve an
inherent risk of product liability claims and associated adverse publicity.
Synbiotics has obtained liability insurance for potential product liability
associated with the commercial sale of its products.  There can be no assurance,
however, that Synbiotics will be able to obtain or maintain such insurance.
Although Synbiotics currently maintains general liability insurance, there can
be no assurance that the coverage limits of Synbiotics' insurance policies will
be adequate.  Product liability insurance is expensive, difficult to obtain and
may not be available in the future on acceptable terms or at all.  A successful
claim brought against Synbiotics in excess of Synbiotics' insurance coverage
could have a material adverse effect upon Synbiotics.

Hazardous Materials
- -------------------

Synbiotics' research and development involves the controlled use of hazardous
materials, chemicals and various radioactive compounds.  Although Synbiotics
believes that its safety procedures for handling and disposing of such materials
comply with the standards prescribed by local state and federal regulations, the
risk of accidental contamination or injury from these materials cannot be
completely eliminated.  In the event of such an accident, Synbiotics could be
held liable for any damages that result and any such liability could exceed the
resources of Synbiotics.  Synbiotics may incur substantial costs to comply with
environmental regulations.


                                USE OF PROCEEDS

All proceeds from the sale of the Shares will be for the account of the Selling
Shareholder, as described below.


                              SELLING SHAREHOLDER

The following table sets forth certain information regarding the Selling
Shareholder's beneficial ownership of the Company's Common Stock as of August
15, 1998.  Except for the licensee relationship created as part of the
settlement of a patent infringement law suit, the Selling Shareholder has not
had a material relationship with the Company within the past three years.  The
numbers set forth in the column "Number of Shares Being Offered" below
constitute all of the Shares that the Selling Shareholder may distribute in this
offering; however, there are currently no agreements, arrangements or
understandings with respect to the sale of any of the Shares and the table below

                                      -7-
<PAGE>
 
assumes the sale of all Shares held by the Selling Shareholder.  The Shares are
being registered to permit public secondary trading of the Shares, and the
Selling Shareholder may offer the Shares for resale from time to time.  See
"Plan of Distribution."

In connection with the settlement, the Selling Shareholder represented that it
was acquiring the Shares for investment and with no present intention of
distributing the Shares.  The Company agreed to prepare and file a registration
statement within 120 days and to bear all expenses other than fees and expenses
of counsel for the Selling Shareholder and discounts, commissions and brokerage
commissions and fees.  Accordingly, the Company filed with the Commission a
Registration Statement on Form S-3, of which this Prospectus forms a part, with
respect to the resale of the Shares from time to time.

The following table sets forth the name of the Selling Shareholder, the number
of shares of Synbiotics Common Stock owned beneficially by the Selling
Shareholder as of August 15, 1998, and the number of shares which may be offered
pursuant to this Prospectus.  Barnes-Jewish Hospital Foundation may assign some
or all of the Shares to Gary J. Weil and/or Senniger, Powers, Leavitt & Roedel,
who would then be in a position to resell those Shares to the public under the
Registration Statement as "Selling Shareholder".

<TABLE>
<CAPTION>
                             Shares Beneficially                           Shares Beneficially
                            Owned Before Offering                         Owned After Offering
                            ----------------------                        ---------------------
                                                      Number of Shares
Selling Shareholder          Number    Percentage    Being Offered/(1)/   Number    Percentage
- -------------------------   --------   -----------   ------------------   -------   -----------
<S>                         <C>        <C>           <C>                  <C>       <C>
Barnes Jewish Hospital       333,333      3.7%            333,333            0           0.0%
Foundation
_______________
</TABLE>


(1)  This assumes that all Shares owned by the Selling Shareholder which are
     offered hereby are sold.  The Selling Shareholder reserves the right to
     accept or reject, in whole or in part, any proposed purchase of Shares.
     The Selling Shareholder may offer less than the amount of Shares indicated.
     No representation is made that any Shares will or will not be offered for
     sale.


                              PLAN OF DISTRIBUTION

The Company is registering the Shares on behalf of the Selling Shareholder.  As
used herein, "Selling Shareholder" also includes donees and pledgees selling
shares received from a named Selling Shareholder after the date of this
Prospectus.  All costs, expenses and fees in connection with the registration of
the Shares offered hereby (other than certain fees and expenses of a Selling
Shareholder's counsel) will be borne by the Company.  Brokerage commissions and
similar selling expenses, if any, attributable to the sale of Shares will be
borne by the Selling Shareholder.  Sales of Shares may be effected by Selling
Shareholder from time to time in one or more types of transactions (which may
include block transactions) on the Nasdaq National Market, in the over-the-
counter market, in negotiated transactions, through put or call transactions
relating to the Shares, through short sales of Shares, or a combination of such
methods of sale, at market prices prevailing at the time of sale, or at
negotiated prices.  Such transactions may or may not involve brokers or dealers.
The Selling Shareholder has advised the Company that the Selling Shareholder has
not entered into any agreements, understandings or arrangements with any
underwriters or broker-dealers regarding the sale of their securities, nor is
there an underwriter or coordinating broker acting in connection with the
proposed sale of Shares by the Selling Shareholder.

The Selling Shareholder may effect such transactions by selling Shares directly
to purchasers or to or through broker-dealers, which may act as agents or
principals.  Such broker-dealers may receive compensation in the form of
discounts, concessions, or commissions from the Selling Shareholder and/or the
purchasers of Shares for whom such

                                      -8-
<PAGE>
 
broker-dealers may act as agents or to whom they sell as principal, or both
(which compensation as to a particular broker-dealer might be in excess of
customary commissions).

The Selling Shareholder and any broker-dealers that act in connection with the
sale of Shares might be deemed to be "underwriters" within the meaning of
Section 2(11) of the Securities Act, and any commissions received by such
broker-dealers and any profit on the resale of the Shares sold by them while
acting as principals might be deemed to be underwriting discounts or commissions
under the Securities Act.  The Company has agreed to indemnify Selling
Shareholder against certain liabilities, including liabilities arising under the
Securities Act.  The Selling Shareholder may agree to indemnify any agent,
dealer or broker-dealer that participates in transactions involving sales of the
Shares against certain liabilities, including liabilities arising under the
Securities Act.

Because a Selling Shareholder may be deemed to be an "underwriter" within the
meaning of Section 2(11) of the Securities Act, the Selling Shareholder will be
subject to the prospectus delivery requirements of the Securities Act.  The
Company has informed the Selling Shareholder that the anti-manipulative
provisions of Regulation M promulgated under the Exchange Act may apply to
Selling Shareholder's sales in the market.

The Selling Shareholder also may resell all or a portion of the Shares in open
market transactions in reliance upon Rule 144 under the Securities Act, provided
the Selling Shareholder meets the criteria and conforms to the requirements of
such Rule.

Upon the Company being notified by a Selling Shareholder that any material
arrangement has been entered into with a broker-dealer for the sale of Shares
through a block trade, special offering, or secondary distribution or a purchase
by a broker or dealer, a supplement to this Prospectus will be filed, if
required, pursuant to Rule 424(b) under the Act, disclosing (i) the name of each
such Selling Shareholder and of the participating broker-dealer(s), (ii) the
number of Shares involved, (iii) the price at which such Shares were sold, (iv)
the commissions paid or discounts or concessions allowed to such broker-
dealer(s), where applicable, (v) that such broker-dealer(s) did not conduct any
investigation to verify the information set out or incorporated by reference in
this Prospectus and (vi) other facts material to the transaction.  In addition,
upon the Company being notified by a Selling Shareholder that a donee or pledgee
intends to sell more than 500 shares, a supplement to this Prospectus will be
filed.

In order to comply with the securities laws of certain states, if applicable,
the Shares may be sold in such jurisdictions only through registered or licensed
brokers or dealers.  In addition, in certain states the Shares may not be sold
unless they have been registered or qualified for sale or an exemption from
registration or qualification requirements is available and is complied with.


                                 LEGAL MATTERS

The validity of the shares offered hereby will be passed upon for the Company by
Brobeck, Phleger & Harrison LLP, San Diego, California.


                                INDEMNIFICATION

Section 317 of the California General Corporation Law provides for the
indemnification of officers and directors of the Company against expenses,
judgments, fines and amounts paid in settlement under certain conditions and
subject to certain limitations.  Under the Company's Articles of Incorporation,
the Company is authorized to provide indemnification of its agents (as defined
in Section 317 of the California Corporations Code) for breach of duty to the
Company and its shareholders through bylaw provisions or through agreements with
the agents, or both, in excess of the indemnification otherwise permitted by
Section 317 of the California Corporations Code, subject to the limits

                                      -9-
<PAGE>
 
on such excess indemnification set forth in Section 204 of the California
Corporations Code.  The Company has entered into such indemnification agreements
with each of its directors and officers.

Article VIII, Section A of the Bylaws of the Company provides that the Company
may indemnify any person who is or was a director, officer, employee or agent of
the Company, or any person who is or was serving at the request of the Company
as a director, officer, employee or agent of another corporation, subject to
certain limitations.  In addition, expenses incurred by a director, officer,
employee or agent in defending a civil or criminal action, suit or proceeding by
reason of the fact that he or she is or was a director, officer, employee or
agent of the Company may be paid by the Company in advance of the final
disposition of such action, suit or proceeding upon receipt of an undertaking by
or on behalf of such director or officer to repay such amount if it shall
ultimately be determined that he or she is not entitled to be indemnified by the
Company.

The Company's Articles of Incorporation provide that the liability of the
Company's directors for monetary damages shall be eliminated to the fullest
extent permissible under California law.

Insofar as indemnification for liabilities arising under the Securities Act of
1933 may be permitted to directors, officers and controlling persons of the
Company pursuant to the foregoing provisions, or otherwise, the Company has been
advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Act and is,
therefore, unenforceable.

The above discussion of the Company's Articles of Incorporation and Bylaws and
of Section 317 of the California General Corporation Law is not intended to be
exhaustive and is qualified in its entirety by such Articles of Incorporation,
Bylaws and statute.

The Company shall indemnify the Selling Shareholder against any untrue statement
of material fact in the Registration Statement.

                                      -10-
<PAGE>
 
                                    PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS


Item 14.   Other Expenses of Issuance and Distribution

The following table sets forth the various costs and expenses to be paid by the
Company with respect to the sale and distribution of the securities being
registered.  All of the amounts shown are estimates except the Securities and
Exchange Commission registration fee.

<TABLE>
<S>                                                    <C>
SEC Registration Fee................................   $   240
Printing Expenses *.................................     1,000
Blue Sky Fees and Expenses *........................         0
Legal Fees and Expenses*............................     5,000
Accounting Fees and Expenses*.......................     3,000
Miscellaneous*......................................     2,760
                                                       -------
       Total........................................   $12,000
                                                       =======
</TABLE>

__________________
*Estimated


Item 15.  Indemnification of Directors and Officers

(a) Section 317 of the California General Corporation Law provides for the
    indemnification of officers and directors of the Company against expenses,
    judgments, fines and amounts paid in settlement under certain conditions and
    subject to certain limitations.  Under the Company's Articles of
    Incorporation, the Company is authorized to provide indemnification of its
    agents (as defined in Section 317 of the California Corporations Code) for
    breach of duty to the Company and its shareholders through bylaw provisions
    or through agreements with the agents, or both, in excess of the
    indemnification otherwise permitted by Section 317 of the California
    Corporations Code, subject to the limits on such excess indemnification set
    forth in Section 204 of the California Corporations Code.  The Company has
    entered into such indemnification agreements with each of its directors and
    officers.

(b) Article VIII, Section A of the Bylaws of the Company provides that the
    Company may indemnify any person who is or was a director, officer, employee
    or agent of the Company, or any person who is or was serving at the request
    of the Company as a director, officer, employee or agent of another
    corporation, subject to certain limitations.  In addition, expenses incurred
    by a director, officer, employee or agent in defending a civil or criminal
    action, suit or proceeding by reason of the fact that he or she is or was a
    director, officer, employee or agent of the Company may be paid by the
    Company in advance of the final disposition of such action, suit or
    proceeding upon receipt of an undertaking by or on behalf of such director
    or officer to repay such amount if it shall ultimately be determined that he
    or she is not entitled to be indemnified by the Company.

(c) The Company's Articles of Incorporation provide that the liability of the
    Company's directors for monetary damages shall be eliminated to the fullest
    extent permissible under California law.

                                      II-1
<PAGE>
 
The above discussion of the Company's Articles of Incorporation, Bylaws and of
Section 317 of the California General Corporation Law is not intended to be
exhaustive and is qualified in its entirety by such Articles of Incorporation,
Bylaws and statute.
 
 
Item 16.  Exhibits


Exhibit
 Number   Exhibit
- -------   -------
    5.1   Opinion and Consent of Brobeck, Phleger & Harrison LLP.

   23.1   Consent of Independent Accountants.

   23.2   Consent of Independent Accountants.

   23.3   Consent of Brobeck, Phleger & Harrison LLP (included in Exhibit 5.1).

   24.1   Power of Attorney (see page II-3).


Item 17.  Undertakings

The undersigned Registrant hereby undertakes:

(1) To file, during any period in which it offers or sells securities, a post-
    effective amendment to this registration statement to include any additional
    or changed material information on the plan of distribution;

(2) That, for determining liability under the Securities Act, each such post-
    effective amendment shall be treated as a new registration statement of the
    securities offered, and the offering of the securities at that time shall be
    treated as the initial bona fide offering; and

(3) To file a post-effective amendment to remove from registration any of the
    securities that remain unsold at the end of the offering.

Insofar as indemnification for liabilities arising under the Securities Act of
1933 may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act
and is, therefore, unenforceable.  In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer, or controlling person of the Registrant
in the successful defense of any action, suit, or proceeding) is asserted by
such director, officer, or controlling person in connection with the securities
being registered, the Registrant will, unless in the opinion of its counsel the
question has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is
against public policy as expressed in the Securities Act and will be governed by
the final adjudication of such issue.

                                      II-2
<PAGE>
 
                                   SIGNATURES
   
Pursuant to the requirements of the Securities Act of 1933, the Company
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, on the 24th day of
September, 1998.     

                                   SYNBIOTICS CORPORATION

                                   By  /s/ Kenneth M. Cohen
                                       --------------------------------
                                   Kenneth M. Cohen, President and 
                                   Chief Executive Officer

                               POWER OF ATTORNEY

Each person whose signature appears below constitutes and appoints Kenneth M.
Cohen as attorney-in-fact, with the power of substitution, for him in any and
all capacities, to sign any amendment to this Registration Statement and to file
the same, with exhibits thereto and other documents in connection therewith,
with the Securities and Exchange Commission, granting to said attorney-in-fact
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorney-in-fact or his substitute or substitutes may
lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration
Statement has been signed below by the following persons in the capacities and
on the dates indicated.
<TABLE>    
<CAPTION>
 
     Signature                               Title                                       Date
     ---------                               -----                                       ----
<S>                         <C>                                                    <C>
 
/s/ Kenneth M. Cohen        Chief Executive Officer, President and Director        September 24, 1998
- ------------------------    (Principal Executive Officer) 
Kenneth M. Cohen            
 
/s/ Michael K. Green        Chief Financial Officer and Vice President - Finance   September 24, 1998
- ------------------------    (Principal Financial Officer) 
Michael K. Green            
 
/s/ Keith A. Butler         Chief Accounting Officer and Corporate Controller      September 24, 1998
- ------------------------    (Principal Accounting Officer) 
Keith A. Butler             
 
           *                Director                                               September 24, 1998
- ------------------------
Patrick Owen Burns
 
           *                Director                                               September 24, 1998
- ------------------------
James C. DeCesare
 
           *                Director                                               September 24, 1998
- ------------------------
Brenda D. Gavin
 
           *                Director                                               September 24, 1998
- ------------------------
M. Blake Ingle
 
           *                Director                                               September 24, 1998
- ------------------------
Skip Klein
 
           *                Director                                               September 24, 1998
- ------------------------
Donald E. Phillips
</TABLE>     
   
* /s/ Kenneth M. Cohen
  ----------------------------------
  Kenneth M. Cohen, attorney-in-fact     

                                      II-3

<PAGE>
 
                                                                     EXHIBIT 5.1

             OPINION AND CONSENT OF BROBECK, PHLEGER & HARRISON LLP



                               September 14, 1998



Synbiotics Corporation
11011 Via Frontera
San Diego, California 92127


Ladies and Gentlemen:

We have acted as counsel to Synbiotics Corporation, a California corporation
(the "Company"), in connection with the registration for resale of 333,333
shares of Common Stock (the "Shares"), as described in the Company's
Registration Statement on Form S-3 ("Registration Statement"), filed with the
Securities and Exchange Commission under the Securities Act of 1933, as amended
(the "Act").

This opinion is being furnished in accordance with the requirements of Item 16
of Form S-3 and Item 601(b)(5)(i) of Regulation S-B under the Act.

We are familiar with the corporate proceedings taken by the Company in
connection with the issuance and sale of the Shares.  It is our opinion that the
Shares are duly authorized, validly issued, fully paid and nonassessable.

We consent to the filing of this opinion as Exhibit 5.1 to the Registration
Statement and to the reference to this firm under the caption "Legal Matters" in
the Prospectus which is part of the Registration Statement.  In giving this
consent, we do not thereby admit that we are within the category of persons
whose consent is required under Section 7 of the Act or the rules and
regulations of the Securities and Exchange Commission promulgated thereunder.

This opinion is expressed as of the date hereof and we disclaim any undertaking
to advise you of any subsequent changes in applicable law or in the facts stated
or assumed herein which may alter, affect or modify the opinion expressed
herein.  Our opinion is expressly limited to the matters set forth above and we
render no opinion, whether by implication or otherwise, as to any other matters
relating to the Company or the Shares.


                         Very truly yours,

                         /s/ Brobeck, Phleger & Harrison LLP
                         -----------------------------------
                         BROBECK, PHLEGER & HARRISON LLP

<PAGE>
 
                                                                    EXHIBIT 23.1

                       CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the incorporation by reference in the Prospectus
constituting part of this Registration Statement on Form S-3 of our report dated
March 25, 1998 appearing on page 16 of Synbiotics Corporation's Annual Report on
Form 10-KSB for the year ended December 31, 1997.


PRICEWATERHOUSECOOPERS LLP

San Diego, California
September 11, 1998

<PAGE>
 
                                                                    EXHIBIT 23.2

                       CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the incorporation by reference in the Prospectus
constituting part of this Registration Statement on Form S-3 of our report dated
March 18, 1998 on our audit of the financial statements of Synbiotics Europe SAS
appearing on page 17 of Synbiotics Corporation's Annual Report on Form 10-KSB
for the year ended December 31, 1997.


COOPERS & LYBRAND AUDIT

Lyons, France
September 9, 1998


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission