SYNBIOTICS CORP
S-3/A, 1999-11-19
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

As filed with the Securities and Exchange Commission on November 19, 1999
                                                      Registration No. 333-90493
- --------------------------------------------------------------------------------
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                          __________________________

                         PRE-EFFECTIVE AMENDMENT NO. 1
                                    FORM S-3
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                          __________________________

                            SYNBIOTICS CORPORATION
            (Exact name of Registrant as specified in its charter)

                    CALIFORNIA                             95-3737816
          (State or other jurisdiction of              (I.R.S. Employer
          incorporation or organization)              Identification No.)

                          __________________________

               11011 Via Frontera , San Diego, California 92127
                                (858) 451-3771
   (Address, including zip code, and telephone number, including area code,
                 of Registrant's principal executive offices)
                          __________________________

                               Kenneth M. Cohen
                     President and Chief Executive Officer
                            SYNBIOTICS CORPORATION
                11011 Via Frontera, San Diego, California 92127
                                (858) 451-3771
(Name, address, including zip code, and telephone number, including area code,
                             of agent for service)
                          __________________________
                                   Copy to:

                            Hayden J. Trubitt, Esq.
                            Matthew B. Swartz, Esq.
                        BROBECK, PHLEGER & HARRISON LLP
                         550 West C Street, Suite 1300
                          San Diego, California 92101
                          __________________________

       Approximate date of commencement of proposed sale to the public:
  From time to time after the effective date of this Registration Statement.

                          __________________________

If the only securities being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box. [_]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [X]

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [_]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [_]

     The Registrant hereby amends this Registration Statement on such date or
dates as may be necessary to delay its effective date until the Registrant shall
file a further amendment which specifically states that this Registration
Statement shall thereafter become effective in accordance with Section 8(a) of
the Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a),
may determine.

- --------------------------------------------------------------------------------
<PAGE>

                            SYNBIOTICS CORPORATION

                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                            Page
                                                                            ----
<S>                                                                         <C>
WHERE YOU CAN FIND MORE INFORMATION.....................................       2

ABOUT SYNBIOTICS CORPORATION............................................       2

RISK FACTORS............................................................       3

FORWARD-LOOKING STATEMENTS..............................................       7

USE OF PROCEEDS.........................................................       8

SELLING SHAREHOLDER.....................................................       8

PLAN OF DISTRIBUTION....................................................       8

LEGAL MATTERS...........................................................       9

INDEMNIFICATION.........................................................       9
</TABLE>
<PAGE>

PROSPECTUS

                                 153,846 Shares

                             SYNBIOTICS CORPORATION
                                  Common Stock

     Our Common Stock is traded on the Nasdaq National Market under the symbol
"SBIO". On November 3, 1999, the closing sale price of Synbiotics Common Stock
as reported on the Nasdaq National Market was $2.50 per share.

     These shares of Common Stock are being sold by S.R. One, Limited, which
received shares of our Common Stock as a result of our acquisition of
International Canine Genetics, Inc. in 1996. We will not receive any part of the
proceeds from the sale.

     See "Risk Factors" on page 3.


- --------------------------------------------------------------------------------

     Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of these securities or passed upon the
accuracy or adequacy of the prospectus.  Any representation to the contrary is a
criminal offense.

- --------------------------------------------------------------------------------

               The date of this prospectus is November 19, 1999.

                                      -1-
<PAGE>

                      WHERE YOU CAN FIND MORE INFORMATION

     We file annual, quarterly and special reports, proxy statements and other
information with the SEC. You may read and copy any document we file at the
SEC's public reference rooms in Washington, D.C., New York, and Chicago. Please
call the SEC at 1-800-SEC-0330 for further information on the public reference
rooms. Our SEC filings are also available to the public at the SEC's web site at
http://www.sec.gov.

     The SEC allows us to "incorporate by reference" the information we file
with them which means that we can disclose important information to you by
referring you to those documents instead of having to repeat the information in
this prospectus. The information incorporated by reference is considered to be
part of this prospectus, and later information that we file with the SEC will
automatically update and supersede this information. We incorporate by reference
the documents listed below and any future filings made with the SEC under
Sections 13(a), 13(c), 14, or 15(d) of the Securities Exchange Act of 1934 until
the selling shareholder sells all the shares.

     --  Annual Report on Form 10-KSB for the year ended December 31, 1998;

     --  Quarterly Reports on Form 10-QSB for the quarters ended March 31, 1999,
         June 30, 1999 and September 30, 1999;

     --  Current Report on Form 8-K/A dated April 2, 1999;

     --  Registration Statement of Form 8-A filed with the SEC on November 14,
         1983. This filing describes the terms, rights and provisions applicable
         to our Common Stock; and

     --  Registration Statement on Form 8-A filed with the SEC on October 7,
         1998. This filing describes the terms, rights and provisions applicable
         to our Preferred Stock Purchase Rights.

You may request a copy of these filings, at no cost, by writing or telephoning
us at the following address:

     Synbiotics Corporation
     11011 Via Frontera
     San Diego, CA 92127
     Attn: Corporate Secretary
     (858) 451-3771

     You should rely only on the information incorporated by reference or
provided in this prospectus or any supplement. We have not authorized anyone
else to provide you with different information. The selling shareholder will not
make an offer of these shares in any state where the offer is not permitted. You
should not assume that the information in this prospectus or any supplement is
accurate as of any date other than the date on the front of those documents.

     This prospectus is part of a registration statement we filed with the SEC
(Registration No. 333-90493).

                         ABOUT SYNBIOTICS CORPORATION

     We are a leading provider of rapid diagnostic and laboratory diagnostic
products for the animal health care industry. We also market a line of animal
vaccines. We were founded in 1982 to research and develop monoclonal antibody-
based diagnostic and therapeutic products. In the early years, we were focused
on developing therapeutics for human diseases. The high cost of human drug
development, however, coupled with the lengthy FDA approval process, motivated
us to begin commercializing its technology through the less restrictive animal
health care market. Synbiotics is one of a small number of companies that
focuses exclusively on animal health and is the second largest provider of
diagnostic products to the animal health market.

     Our principal executive offices are located at 11011 Via Frontera, San
Diego, California 92127, and our telephone number is (858) 451-3771.

                                      -2-
<PAGE>

                                   RISK FACTORS

     You should carefully consider the risks described below together with all
of the other information included in or incorporated by reference into this
prospectus before making an investment decision. The risks and uncertainties
described below are not the only ones facing our company. If any of the
following risks actually occurs, our business, financial condition, results of
operations or cash flows could be materially adversely affected. In such case,
the trading price of our common stock could decline, and you may lose all or
part of your investment.

     The market in which we operate is intensely competitive, particularly with
regard to our key canine heartworm diagnostic products, and many of our
competitors are larger and more established

     The market for animal health care products is extremely competitive.
Companies in the animal health care market compete to develop new products, to
market and manufacture products efficiently, to implement effective research
strategies, and to obtain regulatory approval. Our current competitors include
significantly larger companies such as Pfizer Animal Health, Merial S.A.S. (the
successor to Rhone-Merieux), Schering-Plough and IDEXX Laboratories. These
companies are substantially larger and have greater financial, manufacturing,
marketing, and research resources than we do. Our current competitors also have
extensive expertise in conducting pre-clinical and clinical testing of new
products and in obtaining the necessary regulatory approvals to market products.
In addition, IDEXX Laboratories prohibits its distributors from selling
competitors' products, including ours. Further, additional competition could
come from new entrants to the animal health care market. We cannot assure you
that we will be able to compete successfully in the future or that competition
will not harm our business.

     Our canine heartworm products constitute 46% of our sales. In addition to
our historic competition with IDEXX Laboratories, the sales leader in this
product category, our sales were substantially affected in 1999 by a new
heartworm product from Heska Corporation. We have filed a lawsuit against Heska,
claiming that its heartworm product infringes our patent. Also, we believe
Abbott Laboratories may enter the canine heartworm diagnostic market in 2000. If
so, our market share and average selling prices may decline, perhaps materially.

     We have a history of losses and an accumulated deficit

     Although we generated profits for the years ended December 31, 1997 and
1996, we did not achieve profitability for the year ended December 31, 1998 and
we have had a history of losses.  Synbiotics has incurred a consolidated
accumulated deficit of $11,150,000 at September 30, 1999.  We may not achieve
profitability again and if we are profitable in the future there can be no
assurance that profitability can be sustained.

     We depend on third party manufacturers

     We contract for the manufacture of some of our products, including all of
our vaccines, our Witness(R), VetRED(R) and ICT Gold(TM) diagnostic kits, and
our SCA 2000(TM) instrument. We also expect that some of our anticipated new
products will be manufactured by third parties. In addition, some of the
products manufactured for us by third parties, including Witness(R), VetRED(R)
and ICT Gold(TM) are licensed to us by their manufacturers. There are a number
of risks associated with our dependence on third-party manufacturers including:

     .      reduced control over delivery schedules;

     .      quality assurance;

     .      manufacturing yields and costs;

     .      the potential lack of adequate capacity during periods of excess
            demand;

     .      limited warranties on products supplied to us; and

     .      increases in prices and the potential misappropriation of our
            intellectual property.

                                      -3-
<PAGE>

     If any of our third party manufacturers fail to supply us with an adequate
number of finished products, our business would be significantly harmed. We have
no long-term contracts or arrangements with any of our vendors that guarantee
product availability, the continuation of particular payment terms or the
extension of credit limits.

     In addition, sales of our feline leukemia virus ("FeLV") vaccine to Merial
S.A.S. and other distributors for resale in Europe will be at risk unless our
manufacturer, Bio-Trends International, Inc. ("Bio-Trends"), obtains European
Union regulatory approvals for its manufacturing facilities. Loss of these sales
would have a material adverse effect on our profitability and our cash flows.

     If we encounter delays or difficulties in our relationships with our
manufacturers, the resulting problems could have a material adverse effect on
us. In fact, all of our vaccine products (exclusive of our FeLV and canine
corona virus products) were manufactured using bulk antigen fluids that were
supplied by a third party. The supply agreement expired and we were unable to
locate a replacement supplier for these bulk antigen fluids. We decided to
discontinue the sales of the affected products once our remaining supplies were
exhausted, which occurred during the third quarter of 1999. Sales of the
affected products totaled $2,073,000, $1,596,000 and $1,225,000 during 1998,
1997 and 1996, respectively.

     We rely on third party distributors for a substantial portion of our sales,
but we are experiencing difficulties with the distribution channel

     During the year ended December 31, 1998, sales to two distributors totaled
33% of our net sales. Because we are dependent upon distributors for such a
large portion of our sales, our ability to establish and maintain an adequate
sales and marketing capability in any or all of our targeted markets may be
impaired. Our failure to independently sell and market our products could
materially harm our business. Further, distributor agreements render our sales
exposed to the efforts of third parties who are not employees of Synbiotics and
over whom we have no control. Their failure to generate significant sales of our
products could materially harm our business. Reduction by these distributors of
the quantity of our products which they distribute would materially harm our
business. In addition, IDEXX Laboratories' prohibition against its distributors
carrying competitors' products, including ours, has and could continue to make
some distributors unavailable to us. We adopted a similar policy in the second
quarter of 1999, which caused some of our distributors to abandon our product
line. Although we have rescinded this policy, we do not expect to get the
distributors back to any meaningful extent. We are also exposed to the risk that
any sales by us directly to veterinarians could alienate our current
distributors.

     Our direct selling efforts may not succeed

     We are increasing our efforts to sell our products directly to
veterinarians, including by telesales and overt the Internet. We are
inexperienced in large-scale direct selling efforts and may not be able to
successfully execute this strategy. Also, veterinarians have traditionally
relied on distributors, and the number of veterinarians willing to purchase
directly from manufacturers may be smaller than we believer.

     Our profitable vaccine sales in Europe may decline soon

     Merial distributes in Europe our FeLV vaccine, which we obtain from Bio-
Trends. Our gross profit in 1998 on these sales of FeLV to Merial in Europe was
$520,000. Merial has exercised a contractual right which will enable it, in
2002, to introduce its own FeLV vaccine product in Europe. If Merial does so,
our sales to Merial in Europe would probably decline sharply.

     There is no assurance that acquired businesses can be successfully combined

     There can be no assurance that the anticipated benefits of the 1998
acquisition of Prisma Acquisition Corp. ("Prisma"), the 1997 acquisition of the
veterinary diagnostics business of Synbiotics Europe SAS ("SBIO-E"), the 1996
acquisition of the business of International Canine Genetics, Inc. ("ICG"), or
any other future acquisitions (collectively, the "Acquired Business") will be
realized. Acquisitions of businesses involve numerous risks, including
difficulties in the assimilation of the operations, technologies and products of
the Acquired Business, introduction of different distribution channels,
potentially dilutive issuances of equity and/or increases in leverage

                                      -4-
<PAGE>

and risk resulting from issuances of debt securities, the need to establish
internally operating functions which had been previously provided pre-
acquisition by a corporate parent, accounting charges, operating companies in
different geographic locations with different cultures, the potential loss of
key employees of the Acquired Business, the diversion of management's attention
from other business concerns and the risks of entering markets in which we have
no or limited direct prior experience. In addition, there can be no assurance
that the acquisitions will not have a material adverse effect upon Synbiotics'
business, results of operations, financial condition or cash flows, particularly
in the quarters immediately following the consummation of the acquisition, due
to operational disruptions, unexpected expenses and accounting charges which may
be associated with the integration of the Acquired Business and Synbiotics, as
well as operating and development expenses inherent in the Acquired Business
itself as opposed to integration of the Acquired Business.

     We depend on key executives and personnel

     Our future success will depend, to a significant extent, on the ability of
our management to operate effectively, both individually and as a group.
Competition for qualified personnel in the animal health care products industry
is intense, and we may not be successful in attracting and retaining such
personnel. There are only a limited number of persons with the requisite skills
to serve in those positions and it may become increasingly difficult to hire
such persons.

     The loss of the services of any of our key personnel or the inability to
attract or retain qualified personnel could harm our business.

     We rely on new and recent products

     We rely to a significant extent on new and recently developed products, and
expect that we will need to continue to introduce new products to be successful
in the future. There can be no assurance that we will obtain and maintain market
acceptance of our products. There can be no assurance that future products will
meet applicable regulatory standards, be capable of being produced in commercial
quantities at acceptable cost or be successfully commercialized.

     There can be no assurance that new products can be manufactured at a cost
or in quantities necessary to make them commercially viable. If we are unable to
produce internally, or to contract for, a sufficient supply of our new products
on acceptable terms, or if we should encounter delays or difficulties in our
relationships with manufacturers, the introduction of new products would be
delayed, which could have a material adverse effect on our business.

     We may need additional capital in the future

     We currently anticipate that our existing cash balances and short term
investments and cash flow expected to be generated from future operations will
be sufficient to meet our liquidity needs for at least the next twelve months.
However, we may need to raise additional funds if our estimates of revenues,
working capital and/or capital expenditure requirements change or prove
inaccurate or in order for us to respond to unforeseen technological or
marketing hurdles or to take advantage of unanticipated opportunities.

     Further, our future capital requirements will depend on many factors beyond
our control or ability to accurately estimate, including continued scientific
progress in our product and development programs, the cost of manufacturing
scale-up, the costs involved in preparing, filing, prosecuting, maintaining and
enforcing patent claims, the cost involved in patent infringement litigation,
competing technological and market developments, and the cost of establishing
effective sales and marketing arrangements. In addition, we expect to review
potential acquisitions that would compliment our existing product offerings or
enhance our technical capabilities. While we have no current agreements or
negotiations underway with respect to any such acquisition, any future
transaction of this nature could require potentially significant amounts of
capital. Such funds may not be available at the time or times needed, or
available on terms acceptable to us. If adequate funds are not available, or are
not available on acceptable terms, we may not be able to take advantage of
market opportunities, to develop new products, or to otherwise respond to
competitive pressures. This inability could materially harm our business.

                                      -5-
<PAGE>

     In July 1997, we obtained $15,000,000 of debt financing from Banque
Paribas, of which $11,493,000 was used in connection with our acquisition of
portions of Rhone Merieux S.A.S. The $15,000,000 included a $5,000,000 revolving
line of credit. Draws by us under this line of credit are subject to certain
requirements and can be used only for certain purposes. Additionally, Banque
Paribas requires us to maintain certain financial ratios and levels of tangible
net worth and also restricts our ability to pay dividends and make loans,
capital expenditures, or investments without its consent.

     If adequate funds are not available to us, or if they are not available on
terms reasonably favorable to us, we may need to delay, reduce, or eliminate one
or more of our research and development programs. Any of these events would
impair our competitive position and harm our business.

     Our business is seasonal

     Our operations are seasonal due to the success of our canine heartworm
diagnostic products. Our sales and profits tend to be concentrated in the first
half of the year as our distributors prepare for the heartworm season by
purchasing diagnostic products for resale to veterinarians. The operations of
SBIO-E have reduced our seasonality as sales of their large animal diagnostic
products tend to occur evenly throughout the year. We believe that increased
sales of our instrument products will also reduce our seasonality.

     Our failure to adequately establish or protect our proprietary rights may
     adversely effect us

     We rely on a combination of patent, copyright, and trademark laws, and on
trade secrets and confidentiality provisions and other contractual provisions to
protect our proprietary rights.  These measures afford only limited protection.
We currently have 11 issued U.S. patents and several pending patent
applications.  Our means of protecting our proprietary rights in the U.S. or
abroad may not be adequate and competitors may independently develop similar
technologies.  Our future success will depend in part on our ability to protect
our proprietary rights and the technologies used in our principal products.
Despite our efforts to protect our proprietary rights, unauthorized parties may
attempt to copy aspects of our products or to obtain and use trade secrets or
other information that we regard as proprietary.  In addition, the laws of some
foreign countries do not protect our proprietary rights as fully as do the laws
of the U.S.  Issued patents may not preserve our proprietary position.  Even if
they do, competitors or others may develop technologies similar to or superior
to our own.  If we do not enforce and protect our intellectual property, our
business will be harmed.

     From time to time, third parties, including our competitors, have asserted
patent, copyright, and other intellectual property rights to technologies that
are important to us.  We expect that we will increasingly be subject to
infringement claims as the number of products and competitors in the animal
health care market increases.

     The results of any litigated matter are inherently uncertain.  In the event
of an adverse result in any litigation with third parties that could arise in
the future, we could be required to:

     .      pay substantial damages, including treble damages if we are held to
            have willfully infringed;

     .      cease the manufacture, use and sale of infringing products; . expend
            significant resources to develop non-infringing technology; or

     .      obtain licenses to the infringing technology.

     Licenses may not be available from any third party that asserts
intellectual property claims against us on commercially reasonable terms, or at
all.

     Also, litigation is costly regardless of its outcome and can requires
significant management attention.  For example, in 1997, Barnes-Jewish Hospital
filed an action against claiming that our canine heartworm diagnostic products
infringe their patent.  We settled this lawsuit, but there can be no assurance
that we would be able to successfully resolve similar incidents in the future.

                                      -6-
<PAGE>

  Also, because our patents and patent applications cover novel diagnostic
approaches,

 .      the patent coverage which we receive could be significantly narrower than
       the patent coverage we seek in our patent applications; and

 .      our patent positions involve complex legal and factual issues which can
       be hard for patent examiners or lawyers asserting patent coverage to
       successfully resolve.

     Because of this, our patent position could be vulnerable and our business
     could be materially harmed.
  The U.S. patent application system also exposes us to risks. In the United
States, the first party to make a discovery is granted the right to patent it
and patent applications are maintained in secrecy until the underlying patents
issue. For these reasons, we can never know if we are the first to discover
particular technologies. Therefore, we can never be certain that our
technologies will be patented and we could become involved in lengthy,
expensive, and distracting disputes concerning whether we were the first to make
the disputed discovery. Any of these events would materially harm our business.

  Our business is regulated by the United States and various foreign governments

  Our business is subject to substantial regulation by the United States
government, most notably the United States Department of Agriculture, and the
French government.  In addition, our operations may be subject to future
legislation and/or rules issued by domestic or foreign governmental agencies
with regulatory authority relating to our business.  There can be no assurance
that we will continue to be in compliance with any of these regulations.

  For marketing outside the United States, we, and our suppliers, are subject to
foreign regulatory requirements in such foreign jurisdictions, which vary widely
from country to country.  There can be no assurance that we, and our suppliers,
will meet and sustain compliance with any such requirements.  In particular, our
sales of feline leukemia virus vaccine to Merial S.A.S. or other distributors
for resale in Europe will be at risk unless Bio-Trends, our supplier, obtains
European Union regulatory approvals for its manufacturing facilities.

  Our liability insurance may prove inadequate

  Our products carry an inherent risk of product liability claims and associated
adverse publicity. While we have maintained product liability insurance for such
claims to date, we cannot be certain that this type of insurance will continue
to be available to us or that, if it is available, that it can be obtained on
acceptable terms. Also, our current coverage limits may not be adequate. Any
claim against us which results in our having to pay damages in excess of our
coverage limits will materially harm our business. Even if such a claim is
covered by our existing insurance, the resulting increase in insurance premiums
or other charges would increase our expenses and harm our business.

  We use hazardous materials

  Our business requires that we store and use hazardous materials and chemicals,
including radioactive compounds.  Although we believe that our procedures for
storing, handling, and disposing of these materials comply with the standards
prescribed by local, state, and federal regulations, the risk of accidental
contamination or injury from these materials cannot be completely eliminated.
If any of these materials were mishandled, or if an accident with them occurred,
the consequences could be extremely damaging and we could be held liable for
them.  Our liability for such an event would materially harm our business and
could exceed all of our available resources for satisfying it.

                          FORWARD-LOOKING STATEMENTS

     This prospectus and the documents incorporated by reference into this
prospectus contain forward-looking statements that are based on current
expectations, estimates and projections about our industry, management's
beliefs, and assumptions made by management.  Words such as "anticipates",
"expects", "intends", "plans", "believes", "seeks", "estimates" and variations
of such words and similar expressions are intended to identify such forward-
looking statements.  These statements are not guarantees of future performance
and are subject to certain

                                      -7-
<PAGE>

risks, uncertainties and assumptions that are difficult to predict; therefore,
actual results may differ materially from those expressed or forecasted in any
forward-looking statements. Such risks and uncertainties include those noted in
"Risk Factors" above and in the documents incorporated by reference. We
undertake no obligation to update publicly any forward-looking statements,
whether as a result of new information, future events or otherwise.

                                USE OF PROCEEDS

     We will not receive any of the proceeds from the sale of shares of Common
Stock by the Selling Shareholders.

                               SELLING SHAREHOLDER

     We signed a purchase agreement with S.R. One, Limited on July 23, 1996. In
connection with that purchase agreement, we sold 153,846 shares of our Common
Stock to S.R. One, Limited. Prior to this offering, S.R. One, Limited owned all
of the 153,846 shares. S.R. One, Limited plans to hold the shares for investment
and has no present intention of distributing the shares. S.R. One, Limited's
President serves as a director of Synbiotics. The shares are being registered to
permit the public secondary trading of the shares, and S.R. One, Limited may
offer the shares from time to time (see "Plan of Distribution").

     The following table contains certain information regarding S.R. One,
Limited's beneficial ownership of our Common Stock as of October 31, 1999. The
amount in the column "Number of Shares Being Offered" represents all of the
shares that S.R. One, Limited may distribute in this offering. However, S.R.
One, Limited currently has no agreements, arrangements or understandings related
to the sale of any of the shares. The table assumes that S.R. One, Limited will
sell all of the shares.

<TABLE>
<CAPTION>
                                                   Shares                  Number of                  Shares
                                             Beneficially Owned           Shares Being          Beneficially Owned
                                              Prior to Offering                                   After Offering
                                             ------------------                                   --------------
     Name of Selling Stockholder           Number          Percent          Offered/1/        Number          Percent
 ----------------------------------        -----           -------          ----------        ------          -------
<S>                                        <C>             <C>              <C>               <C>             <C>
S.R. One, Limited                          962,652            10.5%           153,846         808,806             8.8%
</TABLE>

     /1/  S.R. One, Limited may offer less than the total amount of the shares
being registered in this offering, or they may choose not to offer any of the
shares being registered in this offering.

                               PLAN OF DISTRIBUTION

     We are registering the shares on behalf of S.R. One, Limited and any donees
and pledgees who may sell shares received from S.R. One, Limited after the date
of this Prospectus. All costs, expenses and fees in connection with the
registration of the shares offered hereby (other than certain fees and expenses
of the selling shareholder's counsel) will be borne by us. Brokerage commissions
and similar selling expenses, if any, attributable to the sale of shares will be
borne by the selling shareholder. Sales of shares may be effected by the selling
shareholder from time to time in one or more types of transactions (which may
include block transactions) on the Nasdaq National Market, in the over-the-
counter market, in negotiated transactions, through put or call transactions
relating to the shares, through short sales of shares, or a combination of such
methods of sale, at market prices prevailing at the time of sale, or at
negotiated prices. Such transactions may or may not involve brokers or dealers.
The selling shareholders have advised us that they have not entered into any
agreements, understandings or arrangements with any underwriters or broker-
dealers regarding the sale of his securities, nor is there an underwriter or
coordinating broker acting in connection with the proposed sale of shares by the
selling shareholders.

     The selling shareholders may effect such transactions by selling shares
directly to purchasers or to or through broker-dealers, which may act as agents
or principals.  Such broker-dealers may receive compensation in

                                      -8-
<PAGE>

the form of discounts, concessions, or commissions from the selling shareholders
and/or the purchasers of shares for whom such broker-dealers may act as agents
or to whom they sell as principal, or both (which compensation as to a
particular broker-dealer might be in excess of customary commissions).

     The selling shareholders and any broker-dealers that act in connection with
the sale of shares might be deemed to be "underwriters" within the meaning of
Section 2(11) of the Securities Act, and any commissions received by such
broker-dealers and any profit on the resale of the shares sold by them while
acting as principals might be deemed to be underwriting discounts or commissions
under the Securities Act. The Selling Shareholders may agree to indemnify any
agent, dealer or broker-dealer that participates in transactions involving sales
of the shares against certain liabilities, including liabilities arising under
the Securities Act.

     The selling shareholders also may resell all or a portion of the shares in
open market transactions in reliance upon Rule 144 under the Securities Act,
provided he meets the criteria and conforms to the requirements of such Rule.

     When the selling shareholders notify us that a material arrangement has
been entered into with a broker-dealer for the sale of shares through a block
trade, special offering, exchange distribution or secondary distribution or a
purchase by a broker or dealer, a supplement to this prospectus will be filed,
if required, pursuant to Rule 424(b) under the Securities Act, disclosing (i)
the names of the selling shareholders and of the participating broker-dealer(s),
(ii) the number of shares involved, (iii) the price at which such shares were
sold, (iv) the commissions paid or discounts or concessions allowed to such
broker-dealer(s), where applicable, (v) that such broker-dealer(s) did not
conduct any investigation to verify the information set out or incorporated by
reference in this Prospectus and (vi) other facts material to the transaction.
In addition, when the selling shareholders notify us that a donee or pledgee
intends to sell more than 500 shares, we will file a supplement to this
prospectus.

     In order to comply with the securities laws of certain states, if
applicable, the shares may be sold in such jurisdictions only through registered
or licensed brokers or dealers.  In addition, in certain states the shares may
not be sold unless they have been registered or qualified for sale or an
exemption from registration or qualification requirements is available and is
complied with.

                                  LEGAL MATTERS

     Our outside law firm, Brobeck, Phleger & Harrison LLP, San Diego,
California will issue an opinion about the legality of the shares.

                                 INDEMNIFICATION

     Section 317 of the California General Corporation Law allows companies to
indemnify their officers and directors against expenses, judgments, fines and
amounts paid in settlement under certain conditions and subject to certain
limitations.

     Article VIII of our Bylaws provides that we shall indemnify any person who
is or was a director, officer, employee or agent of ours, or any person who is
or was serving at our request as a director, officer, employee or agent of
another corporation, subject to certain limitations.  In addition, expenses
incurred by a director, officer, employee or agent in defending a lawsuit by
reason of that person's relationship with us, may be paid by us in advance of
the final disposition of such lawsuit after we receive an undertaking by or on
behalf of such person to repay such amount if it shall ultimately be determined
that he or she is not entitled to be indemnified by us.

     Our Articles of Incorporation, as amended, provide that none of our
directors shall be liable for monetary damages in an action by or in Synbiotics'
right for breach of a director's duties to us and our shareholders, as set forth
in Section 309 of the California Corporations Code.  However, such provision
does not eliminate or limit the liability of a director:

     (i)   for acts or omissions that involve intentional misconduct or knowing
           or culpable violation of law;

                                      -9-
<PAGE>

     (ii)  for acts or omissions that a director believes to be contrary to our
           best interests or those of our shareholders or that involve the
           absence of good faith on the part of a director;

     (iii) for any transaction from which a director derives an improper
           personal benefit;

     (iv)  for acts or omissions that show a reckless disregard of the
           director's duty in circumstances in which the director was aware, or
           should have been aware in the ordinary course of performing the
           director's duties, of a risk of serious injury to us or to our
           shareholders;

     (v)   for acts or omissions that constitute an unexecuted pattern of
           inattention that amounts to an abdication of the director's duty to
           us; (vi) under Section 310 of the California Corporations Code; or

     (vii) under Section 316 of the California Corporations Code.

Such provision eliminating liability does not eliminate or limit the liability
of an officer for any act or omission as an officer notwithstanding that the
officer is also a director or that his or her actions, if negligent or improper,
have been ratified by the directors.

     We are authorized to provide indemnification of our agents (as defined in
Section 317 of the California Corporations Code) for breach of duty to us and
our shareholders through bylaw provisions or through agreements with the agents,
or both, in excess of the indemnification otherwise permitted by Section 317 of
the California Corporations Code, subject to the limits on such excess
indemnification set forth in Section 204 of the California Corporations Code.
We have entered into such indemnification agreements with each of our directors
and officers.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of
Synbiotics pursuant to these provisions, or otherwise, we have been advised
that, in the opinion of the SEC, such indemnification is against public policy
as expressed in the Securities Act and is, therefore, unenforceable.

                                      -10-
<PAGE>

                                    PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution

     The following table sets forth the various costs and expenses we are paying
with respect to the sale and distribution of the securities being registered.
All of the amounts shown are estimates except the SEC registration fee.

<TABLE>
<S>                                                                                             <C>
SEC Registration Fee................................................................            $   104.78
Printing Expenses*..................................................................            $ 1,000.00
Expenses associated with complying with various states' registrations*..............            $     0.00
Legal Fees and Expenses*............................................................            $ 6,000.00
Nasdaq Market Listing Fee*..........................................................            $     0.00
Accounting Fees and Expenses*.......................................................            $ 3,000.00
Miscellaneous*......................................................................            $ 3,000.00
                                                                                                ----------
  Total.............................................................................            $13,104.78
                                                                                                ----------
</TABLE>

____________________________
*Estimated

Item 15. Indemnification of Directors and Officers


     Section 317 of the California General Corporation Law allows companies to
indemnify their officers and directors against expenses, judgments, fines and
amounts paid in settlement under certain conditions and subject to certain
limitations.

     Article Three of our Bylaws provides that we shall indemnify any person who
is or was a director, officer, employee or agent of ours, or any person who is
or was serving at our request as a director, officer, employee or agent of
another corporation, subject to certain limitations.  In addition, expenses
incurred by a director, officer, employee or agent in defending a lawsuit by
reason of that person's relationship with us, may be paid by us in advance of
the final disposition of such lawsuit after we receive an undertaking by or on
behalf of such person to repay such amount if it shall ultimately be determined
that he or she is not entitled to be indemnified by us.

     Our Articles of Incorporation, as amended, provide that none of our
directors shall be liable for monetary damages in an action by or in Synbiotics'
right for breach of a director's duties to us and our shareholders, as set forth
in Section 309 of the California Corporations Code.  However, such provision
does not eliminate or limit the liability of a director:

     (i)  for acts or omissions that involve intentional misconduct or knowing
          or culpable violation of law;

     (ii) for acts or omissions that a director believes to be contrary to our
          best interests or those of our shareholders or that involve the
          absence of good faith on the part of a director;

     (iii)for any transaction from which a director derives an improper personal
          benefit;

     (iv) for acts or omissions that show a reckless disregard of the director's
          duty in circumstances in which the director was aware, or should have
          been aware in the ordinary course of performing the director's duties,
          of a risk of serious injury to us or to our shareholders;

                                     II-1
<PAGE>

     (v)  for acts or omissions that constitute an unexecuted pattern of
          inattention that amounts to an abdication of the director's duty to
          us;

     (vi) under Section 310 of the California Corporations Code; or

     (vii)under Section 316 of the California Corporations Code;

Such provision eliminating liability does not eliminate or limit the liability
of an officer for any act or omission as an officer notwithstanding that the
officer is also a director or that his or her actions, if negligent or improper,
have been ratified by the directors.

     We are authorized to provide indemnification of our agents (as defined in
Section 317 of the California Corporations Code) for breach of duty to us and
our shareholders through bylaw provisions or through agreements with the agents,
or both, in excess of the indemnification otherwise permitted by Section 317 of
the California Corporations Code, subject to the limits on such excess
indemnification set forth in Section 204 of the California Corporations Code.
We have entered into such indemnification agreements with each of our directors
and officers.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of
Synbiotics pursuant to these provisions, or otherwise, we have been advised
that, in the opinion of the SEC, such indemnification is against public policy
as expressed in the Securities Act and is, therefore, unenforceable.

Item 16. Exhibits

<TABLE>
<CAPTION>
        Exhibit Number     Exhibit
        --------------     -------
       <S>                 <C>
       4.1.1               Purchase Agreement dated July 23, 1996 by and Among
                           Synbiotics, ICG and S.R. One./1/

       4.1.2               Amendments to Purchase Agreement dated September 7,
                           1996, by and Among Synbiotics, ICG and S.R One./2/

         5.1               Opinion of Brobeck, Phleger & Harrison LLP.

        23.1               Consent of Independent Accountants.

        23.2               Consent of Brobeck, Phleger & Harrison LLP (included
                           in Exhibit 5.1).

        24.1               Power of Attorney (see pages II-3 and II-4).
</TABLE>
____________________
     /1/   Incorporated by reference to Exhibit 2.2 to the Registrant's
Registration Statement on Form S-4, Registration No. 333-10343, dated September
12, 1996.

     /2/   Incorporated by reference to Exhibit 2.3 to the Registrant's
Registration Statement on Form S-4, Registration No. 333-10343, dated September
12, 1996.

Item 17. Undertakings

     We hereby undertake:

     (1) To file, during any period in which we offer or sell securities, a
post-effective amendment to this registration statement to include any
additional or changed material information on the plan of distribution;

                                     II-2
<PAGE>

     (2) That, for determining liability under the Securities Act, each such
post-effective amendment shall be treated as a new registration statement of the
securities offered, and the offering of the securities at that time shall be
treated as the initial bona fide offering; and

     (3) To file a post-effective amendment to remove from registration any of
the securities that remain unsold at the end of the offering.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to our directors, officers and controlling persons
pursuant to the foregoing provisions, or otherwise, we have been advised that in
the opinion of the SEC such indemnification is against public policy as
expressed in the Securities Act and is, therefore, unenforceable.  In the event
that a claim for indemnification against such liabilities (other than the
payment by us of expenses incurred or paid by our director, officer, or
controlling person in the successful defense of any action, suit, or proceeding)
is asserted by such director, officer, or controlling person in connection with
the securities being registered, we will, unless in the opinion of our counsel
the question has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by us is
against public policy as expressed in the Securities Act and will be governed by
the final adjudication of such issue.

                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, we certify that
we have reasonable grounds to believe that we meet all of the requirements for
filing on Form S-3 and have duly caused this Registration Statement to be signed
on our behalf by the undersigned, thereunto duly authorized, in the City of San
Diego, State of California, on the 19th day of November, 1999.


                              SYNBIOTICS CORPORATION

                              By  /s/  Michael K. Green
                                  ---------------------
                                  Michael K. Green

                                     II-3
<PAGE>

                               POWER OF ATTORNEY

     Each person whose signature appears below constitutes and appoints Michael
K. Green, as attorney-in-fact, with the power of substitution, for him in any
and all capacities, to sign any amendment to this Registration Statement and to
file the same, with exhibits thereto and other documents in connection
therewith, with the SEC, granting to said attorney-in-fact full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in connection therewith, as fully to all intents and purposes as he
might or could do in person, hereby ratifying and confirming all that said
attorney-in-fact or his substitute or substitutes, may lawfully do or cause to
be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
          Signature                              Title                                             Date
          ---------                              -----                                             ----
<S>                                     <C>                                                    <C>
   /s/ Kenneth M. Cohen                 Chief Executive Officer, President, and                November 19, 1999
- --------------------------                           Director
     Kenneth M. Cohen                      (Principal Executive Officer)

   /s/ Michael K. Green                 Chief Financial Officer, Vice President,               November 19, 1999
- ----------------------------------                   Finance
     Michael K. Green                       (Principal Financial Officer)

   /s/ Keith A. Butler                  Chief Accounting Officer and Corporate                 November 19, 1999
- ----------------------------------                   Controller
     Keith A. Butler

          *
__________________________________                   Director                                  November 19, 1999
     Patrick Owen Burns
          *
__________________________________                   Director                                  November 19, 1999
     James C. DeCesare
          *
__________________________________                   Director                                  November 19, 1999
     Brenda D. Gavin
          *
__________________________________                   Director                                  November 19, 1999
     Joseph Klein III
          *
__________________________________                   Director                                  November 19, 1999
     Donald E. Phillips

  */s/Michael K.Green
- ----------------------------------
Michael K. Green, attorney in-fact
</TABLE>

                                     II-4
<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION

                            WASHINGTON, D.C.  20549

                                   EXHIBITS

                                      TO

                                   FORM S-3

                                     UNDER

                            SECURITIES ACT OF 1933

                            SYNBIOTICS CORPORATION




<PAGE>

                                 EXHIBIT INDEX
                                 -------------

          Exhibit Number      Exhibit
          --------------      -------

               4.1.1          Purchase Agreement dated July 23, 1996 by and
                              Among Synbiotics, ICG and S.R. One./1/

               4.1.2          Amendment to Purchase Agreement dated July 23,
                              1996, by and among Synbiotics, International
                              Canine Genetics, and S.R One./2/

                 5.1          Opinion of Brobeck, Phleger & Harrison LLP.

                23.1          Consent of Independent Accountants.

                23.2          Consent of Brobeck, Phleger & Harrison LLP
                              (included in Exhibit 5.1).

                24.1          Power of Attorney (see pages II-3 and II-4).

_________________

          /1/  Incorporated by reference to Exhibit 2.2 to the Registrant's
Registration Statement on Form S-4, Registration No. 333-10343, dated September
12, 1996.

          /2/  Incorporated by reference to Exhibit 2.3 to the Registrant's
Registration Statement on Form S-4, Registration No. 333-10343, dated September
12, 1996.

<PAGE>

                                  EXHIBIT 5.1

                  OPINION OF BROBECK, PHLEGER & HARRISON LLP

                               November 19, 1999

Synbiotics Corporation
11011 Via Frontera
San Diego, California 92127

     Re:  Synbiotics Corporation Registration Statement on Form S-3 for 153,846
          Shares of Common Stock

Ladies and Gentlemen:

     We have acted as counsel to Synbiotics Corporation, a California
corporation (the "Company"), in connection with the registration for resale of
153,846 shares of Common Stock (the "Shares") on Form S-3 (the "Registration
Statement") under the Securities Act of 1933, as amended.

     This opinion is being furnished in accordance with the requirements of Item
16 of Form S-3 and Item 601(b)(5)(i) of Regulation S-B.

     We have reviewed the Company's charter documents and the corporate
proceedings taken by the Company in connection with the issuance and sale of the
Shares.

     Based on such review, we are of the opinion that the Shares have been duly
authorized, legally issued, fully paid and nonassessable.

     We consent to the filing of this opinion letter as Exhibit 5.1 to the
Registration Statement and to the reference to this firm under the caption
"Legal Matters" in the prospectus which is part of the Registration Statement.
In giving this consent, we do not thereby admit that we are within the category
of persons whose consent is required under Section 7 of the Act, the rules and
regulations of the Securities and Exchange Commission promulgated thereunder, or
Item 509 of Regulation S-B.

     This opinion is rendered as of the date first written above and we disclaim
any obligation to advise you of facts, circumstances, events or developments
which hereafter may be brought to our attention and which may alter, affect or
modify the opinion expressed herein. Our opinion is expressly limited to the
matters set forth above and we render no opinion, whether by implication or
otherwise, as to any other matters relating to the Company or the Shares.

                              Very truly yours,

                              /s/ Brobeck, Phleger & Harrison LLP
                              BROBECK, PHLEGER & HARRISON LLP

<PAGE>

                                 EXHIBIT 23.1

                      CONSENT OF INDEPENDENT ACCOUNTANTS

     We hereby consent to the incorporation by reference in this Registration
Statement on Form S-3 of our report dated March 11, 1999 relating to the
financial statements which appear in Synbiotics Corporation's Annual Report on
Form 10-KSB for the year ended December 31, 1998.

PRICEWATERHOUSECOOPERS LLP

San Diego, California
November 19, 1999


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