MOLECULAR BIOSYSTEMS INC
S-8, 1997-09-15
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                              --------------------

                                    FORM S-8

             Registration Statement under the Securities Act of 1933
                              --------------------


                           MOLECULAR BIOSYSTEMS, INC.
             (Exact name of Registrant as specified in its charter)

                               Delaware 36-3078632
                  (State or other jurisdiction (I.R.S. Employer
            of incorporation or organization) Identification Number)

                            10030 Barnes Canyon Road
                           San Diego, California 92121
                    (Address of principal executive offices)

                           Molecular Biosystems, Inc.
                    1997 Outside Directors Stock Option Plan
                            (Full title of the plan)

                                Bobba Venkatadri
                      President and Chief Executive Officer
                           Molecular Biosystems, Inc.
                            10030 Barnes Canyon Road
                           San Diego, California 92121
                                 (619) 452-0681
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)



- ------------ -------------  -----------------  ------------------  -------------

 Title of    Amount To Be   Proposed Maximum    Proposed Maximum      Amount of
Securities    Registered     Offering Price        Aggregate        Registration
  To Be                       Per Share(1)         Offering            Fee(1)
Registered                                         Price(1)
- ------------ -------------  -----------------  -------------------  ------------
- ------------ -------------  -----------------  -------------------  ------------
Common Stock,  300,000             $9.06          $2,718,000.00        $823.64
par value      shares
$.01 per
share

- ----------- --------------  ------------------  ------------------  ------------

(1) Computed pursuant to Rule 457(c), in accordance with Rule 457(h)(1),  on the
basis  of the  average  of the  high  and low  sales  prices  of a share  of the
Registrant's  Common  Stock  reported  on the New York Stock  Exchange,  Inc. on
September 2, 1997.

<PAGE>



                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

Item 1.    Plan Information

       The  information  required  by Item 1 is omitted  from this  Registration
Statement in accordance with the Note to Part I of Form S-8.

Item 2.    Registrant Information and Employee Plan Annual Information

       The  information  required  by Item 2 is omitted  from this  Registration
Statement in accordance with the Note to Part I of Form S-8.


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.    Incorporation of Documents by Reference

       The Registrant  incorporates by reference in this Registration  Statement
the following  documents  which the Registrant has filed with the Securities and
Exchange Commission (the "Commission"):

       (a) the  Annual  Report on Form 10-K which the  Registrant  filed for the
fiscal year ended March 31, 1997;

       (b) the Quarterly  Report on Form 10-Q which the Registrant filed for the
           quarterly period ended June 30, 1997;

       (c) the  Current  Report on Form 8-K,  dated  April 21,  1997,  which the
Registrant filed on May 12, 1997; and

       (d) the description of the Registrant's  Common Stock, par value $.01 per
           share,  contained in the Registration Statement on Form 8-A which the
           Registrant filed on July 9, 1984 (Registration No. 2-83721), together
           with any  amendment  or report that the  Registrant  may file for the
           purpose of updating this description.

       All documents that the Registrant  files with the Commission  pursuant to
Sections 13(a),  13(c),  14 or 15(d) of the Securities  Exchange Act of 1934, as
amended, after the filing of this Registration Statement but prior to the filing
of a post-effective  amendment (1) which indicates that all of the shares of the
Registrant's Common Stock covered by this Registration  Statement (the "Shares")
have been sold or (2) which deregisters all of the Shares then remaining unsold,
shall  be  deemed  to be  incorporated  by  reference  in and to be part of this
Registration Statement from their respective dates of filing.

       Any statement in a document  incorporated or deemed to be incorporated by
reference  in this  Registration  Statement  shall be deemed to be  modified  or
superseded to the extent that a statement in this Registration  Statement, or in
any  document  filed after the filing of this  Registration  Statement  which is
deemed to be incorporated by reference in this Registration Statement,  modifies
or supersedes the earlier statement. The earlier statement shall be deemed to be
incorporated in this Registration Statement only as so modified or superseded.

Item 4.    Description of Securities

       This item is not applicable.

Item 5.    Interests of Named Experts and Counsel

       The  legality of the Shares is being  passed upon for the  Registrant  by
Johnson and Colmar, 300 South Wacker Drive, Suite 1000, Chicago, Illinois 60606,
who serve as the Registrant's outside general counsel.

       Craig P.  Colmar,  who is a partner of Johnson  and  Colmar,  is also the
Company's Secretary.  Mr. Colmar owns of record and beneficially 1,000 shares of
Common  Stock,  and other  partners  of  Johnson  and  Colmar  own of record and
beneficially  a further 1,200 shares.  In addition,  Mr. Colmar holds options to
purchase  35,750 shares of the  Registrant's  Common Stock.  These stock options
were granted at option prices equal to the fair market value of the Registrant's
Common Stock on the dates of grant.

Item 6.    Indemnification of Directors and Officers

       Section 145 of the Delaware  General  Corporation Law provides  generally
that a person sued as a director,  officer,  employee or agent of a  corporation
may be  indemnified  by the  corporation  in  non-derivative  suits for expenses
(including attorneys' fees), judgments,  fines and amounts paid in settlement if
he or she acted in good faith and in a manner that he or she reasonably believed
to be in, or not opposed to, the  corporation's  best interests.  In the case of
criminal actions and  proceedings,  the person must also not have had reasonable
cause to  believe  that his or her  conduct  was  unlawful.  Indemnification  of
expenses is also  authorized  in  stockholder  derivative  actions if the person
acted in good faith and in a manner that he or she reasonably believed to be in,
or not opposed to, the  corporation's  best  interests  and if he or she has not
been found liable to the corporation.  Even in this latter  instance,  the court
may determine that in view of all of the circumstances the person is entitled to
indemnification  for such expenses as the court deems proper. A person sued as a
director, officer, employee or agent of a corporation who has been successful in
defense of the action must be indemnified by the corporation  against his or her
expenses.

       Article 11 of the Registrant's certificate of incorporation,  as amended,
requires the  Registrant to indemnify  its  directors,  officers,  employees and
agents to the maximum extent permitted by Delaware law. Article 11 also requires
the Registrant to advance the litigation  expenses of a director or officer upon
receipt of his or her written undertaking to repay all amounts advanced if it is
ultimately determined that he or she is not entitled to indemnification.

       Section  102(b)(7)  of the  Delaware  General  Corporation  Law permits a
Delaware  corporation to include a provision in its certificate of incorporation
eliminating or limiting the personal  liability of a director to the corporation
or its  stockholders  for monetary  damages for breach of the director's duly of
care.  Such a provision  may not  eliminate or limit the liability of a director
for breaching his or her duty of loyalty, failing to act in good faith, engaging
in  intentional  misconduct or knowingly  violating a law,  declaring an illegal
dividend or  approving  an illegal  stock  repurchase,  or obtaining an improper
personal benefit.

       Article 10 of the Registrant's certificate of incorporation,  as amended,
eliminates the personal  liability of the Registrant's  directors to the fullest
extent permitted by Delaware law.

       Through directors' and officers' liability insurance which the Registrant
maintains,  the  Registrant's  directors  and officers are also insured  against
actual liabilities, including liabilities under the federal securities laws, for
acts or omissions related to the conduct of their duties.

Item 7.    Exemption from Registration Claimed

       This item is not applicable.

Item 8.    Exhibits

   4.1    Molecular Biosystems, Inc. 1997 Outside Directors Stock Option Plan

   5.1    Opinion of Johnson and Colmar

  23.1    Consent of Arthur Andersen LLP

  23.2    Consent of Johnson and Colmar (filed as part of Exhibit 5.1)

  24.1    Power of attorney  (included under the caption "Power of Attorney"
          on page 7).

Item 9.    Undertakings

Rule 415 Offering

       The Registrant undertakes:

           (1) to file,  during  any  period in which  offers or sales are being
       made, a post-effective amendment to this Registration Statement:

                (a) to include any  prospectus  required by Section  10(a)(3) of
           the Securities Act of 1933, as amended (the "Securities Act");

                (b) to reflect  in the  prospectus  any facts or events  arising
           after the effective date of this Registration  Statement (or the most
           recent  post-effective  amendment)  which,  individually  or  in  the
           aggregate,  represent a  fundamental  change in the  information  set
           forth in this Registration Statement; and

                (c) to include any material information with respect to the plan
           of  distribution  not  previously   disclosed  in  this  Registration
           Statement  or  any  material  change  to  such  information  in  this
           Registration Statement;

       provided, however, that undertakings (1)(a) and (1)(b) shall not apply if
       the information required to be included in a post-effective  amendment by
       those  undertakings  is  contained  in  periodic  reports  filed  with or
       furnished to the Commission by the  Registrant  pursuant to Section 13 or
       Section  15(d) of the  Securities  Exchange Act of 1934,  as amended (the
       "Exchange Act") which are incorporated by reference in this  Registration
       Statement;

           (2) that,  for the purpose of  determining  any  liability  under the
       Securities Act, each such post-effective  amendment shall be deemed to be
       a new registration  statement relating to the securities offered therein,
       and the  offering of such  securities  at that time shall be deemed to be
       the initial bona fide offering thereof; and

           (3)  to  remove  from  registration  by  means  of  a  post-effective
       amendment any of the securities  being  registered which remain unsold at
       the termination of the offering; and

Filings Incorporating Subsequent Exchange Act Documents by Reference

       The Registrant undertakes that, for purposes of determining any liability
under the Securities Act, each filing of the Registrant's annual report pursuant
to Section 13(a) or Section 15(d) of the Exchange Act which is  incorporated  by
reference  in  this  Registration   Statement  shall  be  deemed  to  be  a  new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

Commission Position on Indemnification

       Insofar as indemnification  for liabilities  arising under the Securities
Act may be  permitted to  directors,  officers  and  controlling  persons of the
Registrant  pursuant to the Delaware General Corporation Law or the Registrant's
certificate of incorporation,  as amended,  as described in Item 6, or otherwise
permitted, the Registrant has been advised that in the opinion of the Commission
such indemnification is against public policy as expressed in the Securities Act
and is, therefore,  unenforceable. In the event that a claim for indemnification
against such  liabilities  (other than the payment by the Registrant of expenses
incurred or paid by a director,  officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or  controlling  person in  connection  with the Shares,  the
Registrant  will,  unless in the  opinion  of its  counsel  the  matter has been
settled by controlling precedent,  submit to a court of appropriate jurisdiction
the question  whether such  indemnification  by it is against  public  policy as
expressed in the Securities  Act and will be governed by the final  adjudication
of such issue.

<PAGE>

                                   SIGNATURES

       Pursuant to the  requirements  of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly authorized,  in the City of San Diego, State of California, on September 8,
1997.


                                                     Molecular Biosystems, Inc.


                                                     By: /s/ BOBBA VENKATADRI
                                                         Bobba Venkatadri
                                                         President and Chief 
                                                         Executive Officer

                                Power of Attorney

       Each  person  whose  signature  appears  below who is then an  officer or
director of the Registrant  authorizes  Bobba Venkatadri and Gerard A. Wills, or
either of them, with full power of substitution and  resubstitution,  to sign in
his name and to file any  amendments  (including  post-effective  amendments) to
this Registration Statement) and all related documents necessary or advisable to
enable the Registrant to comply with the Securities Act of 1933, as amended,  in
connection  with the  registration  of the securities  which are covered by this
Registration  Statement,   which  amendments  may  make  such  changes  in  this
Registration  Statement (as it may be so amended) as Bobba  Venkatadri or Gerard
A. Wills or either of them,  may deem  appropriate,  and to do and  perform  all
other related acts and things necessary to be done.

       Pursuant to the  requirements  of the Securities Act of 1933, as amended,
this  Registration  Statement has been signed below by the following  persons in
the capacities and on the dates indicated.


<PAGE>

Name                                Title                            Date



/s/ BOBBA VENKATADRI         President, Chief Executive        September 8, 1997
Bobba Venkatadri             Officer and a Director 
                             (Principal Executive Officer)


/s/ GERARD A. WILLS          Vice President, Finance and Chief September 8, 1997
Gerard A. Wills              Financial Officer (Principal
                             Financial and Accounting Officer)

/s/ KENNETH J. WIDDER, M.D   Chairman of the                   September 8, 1997
Kenneth J. Widder, M.D.      Board of Directors


/s/ DAVID W. BARRY, M.D.     Director                          September 8, 1997
David W. Barry, M.D.

/s/ ROBERT W. BRIGHTFELT     Director                          September 8, 1997
Robert W. Brightfelt

/s/ CHARLES C. EDWARDS, M.D. Director                          September 8, 1997
Charles C. Edwards, M.D.

/s/ JERRY T. JACKSON         Director                          September 8, 1997
Jerry T. Jackson

/s/ GORDON C. LUCE           Director                          September 8, 1997
Gordon C. Luce

/s/ DAVID RUBINFIEN          Director                          September 8, 1997
David Rubinfien

<PAGE>


                                Index to Exhibits



       Exhibit  Description                                         Sequentially
       Number                                                         Numbered
                                                                        Page
         4.1    Molecular Biosystems, Inc. 1997 Outside Directors
                Stock Option Plan                                         9
     
         5.1    Opinion of Johnson and Colmar                             14

        23.1    Consent of Arthur Andersen LLP                            16

        23.2    Consent of Johnson and Colmar
                (filed as part of Exhibit 5.1)                            -
     
        24.1    Power of Attorney (included under the caption
                "Power of Attorney" on  page 6)                           -
                      
            
<PAGE>



                                                                     Exhibit 4.1

                           MOLECULAR BIOSYSTEMS, INC.

                    1997 OUTSIDE DIRECTORS STOCK OPTION PLAN

                                    Article 1

                           PURPOSE AND EFFECTIVE DATE

        1.1  Purpose.  The purpose of the Plan is to permit the Company to grant
stock  options to its outside  directors to reward them for their efforts on the
Company's  behalf and to provide an  additional  incentive to  contribute to the
attainment of the Company's long-term plans and objectives.

        1.2 Effective Date. The Plan shall become effective if and when approved
by the Company's shareholders at the 1997 Annual Meeting of Shareholders.

        1.3 Term.  The Plan shall have a term of 10 years  expiring on the tenth
anniversary of its effective date. No Option may be granted under the Plan after
its expiration.


                                    Article 2

                                   DEFINITIONS

        2.1  Annual   Meeting   means  the  annual   meeting  of  the  Company's
shareholders.

        2.2 Board means the Company's Board of Directors. If the Board delegates
its authority to  administer  the Plan to a committee of the Board in accordance
with Article 4,  references  to the "Board"  shall be construed as references to
the committee.

        2.3   Common Stock means shares of the Company's common stock, $.01 par
 value.

        2.4   Company means Molecular Biosystems, Inc., a Delaware corporation.

        2.5   Director means a director of the Company.

        2.6 Expiration Date is defined in Paragraph 5.3.

        2.7 Grant Date is defined in Paragraph 5.1.

        2.8 Officer  means:  (i) the  Company's  Chairman of the Board and Chief
Executive  Officer;  (ii) the Company's  President and Chief Operating  Officer;
(iii)  any Vice  President  of the  Company;  and (iv) any other  person  who is
considered an "officer" of the Company for purposes of Rule  16a-1(f)  under the
Securities Exchange Act of 1934.


<PAGE>



        2.9   Option is defined in Paragraph 5.1.

      2.10 Option Agreement is defined in Paragraph 5.6.

      2.11  Outside  Director  means a Director who is neither an Officer nor an
employee  of the  Company or any  corporation  in which the  Company  owns stock
possessing  at least 50% of the total  combined  voting  power of all classes of
stock.

      2.12    Plan means this stock  option  plan,  as it may be  amended.  The
name of the Plan is the  "Molecular Biosystems, Inc. 1997 Outside Directors 
Stock Option Plan."


                                    Article 3

                           TYPE AND NUMBER OF OPTIONS

        3.1  Type  of  Options.   The  Options   granted  under  this  Plan  are
nonstatutory stock options.

        3.2 Maximum  Number of Options.  The maximum  number of shares of Common
Stock for which  Options  may be granted is 300,000  (subject to  adjustment  as
provided in Paragraph 7.1). If any Option expires  unexercised or is surrendered
prior to the Plan's  expiration,  the number of Underlying  Shares in respect of
the Option shall be added back to the number of shares of Common Stock for which
Options may be granted  under the Plan.  The  Underlying  Shares to be delivered
upon the exercise of an Option may be either  authorized but unissued  shares or
issued shares reacquired by the Company (or any combination of the two).


                                    Article 4

                                 ADMINISTRATION

         The Plan shall be  administered  by the Board.  Subject to the  express
provisions  of the Plan,  the Board may  interpret  the Plan,  adopt and  revise
policies and  procedures to  administer  the Plan,  and make all  determinations
required for the Plan's administration.  The actions of the Board shall be final
and binding.  The Board may delegate its authority to its Executive Committee or
to  another  committee  appointed  by  the  Board  consisting  of at  least  two
Directors.


                                    Article 5

                                  STOCK OPTIONS

         5.1  Option Grants.

         (a)  Annual  Grant.  On the last  business  day in  March of each  year
              (beginning with March 1997) (the "Grant Date"),  the Company shall
              grant  each  incumbent  Outside  Director  who was  elected at the
              preceding  Annual  Meeting  an option  for 6,500  shares of Common
              Stock (an  "Option").  No Option  shall be granted to an incumbent
              Outside  Director  who was not  elected  at the  preceding  Annual
              Meeting but was subsequently  elected or appointed by the Board to
              fill a vacancy.

         (b)  Discretionary  Grant.  The Board shall have the authority to grant
              options to an Outside  Director in amounts greater than the annual
              grant  to  that  Outside  Director  set  forth  in  the  preceding
              subparagraph,  provided that no Outside Director shall be entitled
              to receive  Options for more than 21,500 shares of Common Stock in
              any  fiscal  year.  The date on which the Board  acts to grant any
              such options shall be the Grant Date.

         5.2  Exercise  Price.  The  exercise  price of each Option shall be the
closing  price of the Company's  Common Stock on the New York Stock  Exchange on
the Grant Date (or on the last trading day preceding the Grant Date if it is not
a trading day).

         5.3 Term.  Each Option shall have a 10-year term  expiring on the tenth
anniversary  of the  Grant  Date  (the  "Expiration  Date")  (subject  to  early
expiration as provided in Paragraph  5.4). The Board shall determine (i) whether
each  Option  shall be  exercisable  in full at one time or in  installments  at
different  times and (ii) the time or times at which the Option or  installments
shall become exercisable. No Option or installment shall be exercisable prior to
the  first  anniversary  of the Grant  Date,  except  as its  exercisability  is
accelerated by the Board.  The Board may accelerate  the  exercisability  of any
Option or installment at any time.

         5.4 Death of Outside  Director.  The failure of the Outside Director to
whom an Option was  granted to remain an  Outside  Director  shall not cause the
Option to expire or  otherwise  terminate;  but in the event of the death of the
Outside Director (whether or not he or she is then an incumbent  Director),  the
Option shall expire on the earlier of (i) the first  anniversary  of the Outside
Director's death or (ii) the Option's Expiration Date.

         5.5 Transferability.  No Option may be transferred, assigned or pledged
(whether by  operation of law or  otherwise),  except as provided by will or the
applicable  intestacy  laws,  and no  Option  shall  be  subject  to  execution,
attachment or similar process. An Option or Installment may be exercised only by
Outside Director to whom it was granted, except in the case of his or her death,
when it may be  exercised  by the person or persons to whom it passes by will or
inheritance.

         5.6 Option  Agreements.  Each Option  shall be  evidenced  by a written
agreement (an "Option Agreement"), in a form approved by the Board, entered into
by the Company and the Outside Director to whom the Option is granted.


                                    Article 6

                               EXERCISE OF OPTIONS

         6.1 Manner of Exercise.  An exercisable Option may be exercised in full
or in part (but only in  respect of a whole  number of  shares)  by (i)  written
notice to the Board (or its  designee)  stating  the  number of shares of Common
Stock in respect of which the Option is being exercised and (ii) full payment of
the exercise price of those shares.

         6.2  Payment of Exercise  Price.  Payment of the  exercise  price of an
Option shall be made by certified or bank cashier's check or by wire transfer of
immediately  available  funds  or, if  permitted  by the  Board  (either  in the
applicable  Option  Agreement  or at the time of  exercise):  (i) by  delivering
shares of Common Stock having a fair market value on the date of exercise  equal
to the  exercise  price;  (ii) by directing  the Company to  withhold,  from the
shares of Common Stock otherwise issuable upon exercise of the Option, shares of
Common  Stock  having a fair market  value on the date of exercise  equal to the
exercise  price;  (iii) by  surrendering  exercisable  Options which have a fair
market value on the date of exercise equal to the exercise price  (measuring the
fair market value of the Options  surrendered by the excess of (y) the aggregate
fair market value on the date of exercise of the shares of Common Stock issuable
upon exercise of the Option over (z) the aggregate exercise price);  (iv) by any
combination of the preceding  methods of payment;  or (v) by any other method of
payment  authorized by the Board.  For purposes of this  Paragraph and Paragraph
6.3),  "fair market value" shall be determined by the closing price of shares of
the  Company's  Common Stock on the date in question (or on the last trading day
preceding the date in question if it is not a trading day).

         6.3 Withholding. Each Outside Director exercising an Option shall remit
to the Company an amount sufficient to satisfy the Company's federal,  state and
local withholding tax obligation in connection with the exercise.  Payment shall
be made by certified or bank cashier's  check or by wire transfer of immediately
available  funds or, if permitted by the Board (either in the applicable  Option
Agreement or at the time of  exercise),  by either one or both of the  following
methods:  (i) by delivering shares of Common Stock having a fair market value on
the date of exercise equal to the Company's withholding  obligation;  or (ii) by
directing  the Company to withhold,  from the shares of Common  Stock  otherwise
issuable  upon  exercise of the  Option,  shares of Common  Stock  having a fair
market  value  on the  date  of  exercise  equal  to the  Company's  withholding
obligation.


<PAGE>



                                    Article 7

                            MISCELLANEOUS PROVISIONS

         7.1  Capitalization  Adjustments.  The  aggregate  number  of shares of
Common  Stock for which  Options may be granted  under the Plan,  the  aggregate
number of  Underlying  Shares in respect  of each  outstanding  Option,  and the
exercise  price of each such Option may be adjusted by the Board as it considers
appropriate  in the event of  changes  in the  number of  outstanding  shares of
Common  Stock by reason of stock  dividends,  stock  splits,  recapitalizations,
reorganizations and the like. Adjustments under this Paragraph 7.1 shall be made
in the Board's discretion, and its decisions shall be final and binding.

         7.2  Amendment  and  Termination.  The  Board  may  amend,  suspend  or
terminate  the Plan at any  time;  but  except  to comply  with  changes  in the
Internal  Revenue  Code of 1986 and the  related  regulation,  the Board may not
amend the Plan more once every six months to change: (i) the number of shares of
Common Stock for which Options may be granted under the Plan;  (ii) the benefits
under the Plan; or (iii) the eligibility requirements of the Plan. The Company's
shareholders  shall be  required to approve  any such  amendment  (other than an
amendment  authorized  under Paragraph 7.1) that would  materially  increase the
number of shares,  materially  increase  the benefits or  materially  change the
eligibility requirements.  If the Plan is terminated, the provisions of the Plan
shall  continue  to apply  to  Options  granted  prior  to  termination,  and no
amendment,  suspension or  termination  of the Plan shall  adversely  affect the
rights of an Outside  Director in respect of any Option held  without his or her
consent.

         7.3 Compliance  with Section 16(b).  The Plan shall be interpreted  and
administered  in a manner that  satisfies the  applicable  requirements  of Rule
16b-3  under the  Securities  Exchange  Act so that  Outside  Directors  will be
entitled to the benefits of Rule 16b-3.

         7.4 No  Right  To  Nomination.  Nothing  in the  Plan or in any  Option
Agreement  shall  confer on any  Outside  Director  the right to  continue to be
nominated for election as a Director.
         7.5  Notices.  Notices  required or  permitted  under the Plan shall be
considered  to have been duly  given if sent by  certified  or  registered  mail
addressed  to the Board at the  Company's  principal  office  or to any  Outside
Director at his or her address as it appears on the Company's records.

         7.6  Severability.  If any  provision  of the Plan is held  illegal  or
invalid  for any  reason,  the  illegality  or  invalidity  shall not affect the
remaining provisions, and the Plan shall be construed and administered as if the
illegal or invalid provision had not been included.

         7.7 Governing Law. The Plan and all Option Agreements shall be governed
in accordance with the laws of the State of California.



<PAGE>



                                                                     Exhibit 5.1


                                  [Letterhead]




                                                     September 8, 1997





  Board of Directors
  Molecular Biosystems, Inc.
  10030 Barnes Canyon Road
  San Diego, California 92121


                             Re:    Registration Statement on Form S-8 -
                    1997 Outside Directors Stock Option Plan

  Gentlemen:

       We have acted as counsel to Molecular Biosystems, Inc. (the "Company") in
  connection  with the  preparation  and filing with the Securities and Exchange
  Commission  of  a  Registration  Statement  on  Form  S-8  (the  "Registration
  Statement") for the registration under the Securities Act of 1933, as amended,
  of 300,000 shares of the Company's Common Stock, par value $.01 per share (the
  "Shares"),  to be issued upon the exercise of options granted or to be granted
  under the Molecular Biosystems,  Inc. 1997 Outside Directors Stock Option Plan
  (the "Plan").

       As such counsel,  we have examined the Plan, the Registration  Statement,
  the Company's  certificate of  incorporation  and by-laws,  each as amended to
  date, minutes of meetings and records of proceedings of the Company's Board of
  Directors  and  stockholders,  and such other matters of fact and questions of
  law as we have considered  necessary to form the basis of our opinion.  In the
  course of this examination, we have assumed the genuineness of all signatures,
  the  authenticity  of  all  documents  and  certificates  submitted  to  us as
  originals  by  representatives  of the  Company,  public  officials  and third
  parties,  and the  conformity  to and  authenticity  of the  originals  of all
  documents and certificates submitted to us as copies.


<PAGE>




  Board of Directors
  September 8, 1997
  Page Two


       On the basis of our  examination,  we are of the opinion that the Company
  has duly  authorized and reserved the Shares for issuance upon the exercise of
  options granted or to be granted under the Plan and that, when issued upon the
  exercise and in accordance  with the terms of options granted or to be granted
  under the Plan  (including,  but not  limited  to, the terms of payment of the
  option  price),  the  Shares  will be will be validly  issued,  fully paid and
  non-assessable.

       We  consent to the use of our  opinion as an exhibit to the  Registration
Statement.


  Very truly yours,

  /s/ JOHNSON AND COLMAR

  Johnson and Colmar


<PAGE>



                                                                    Exhibit 23.1


                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

  As independent public  accountants,  we hereby consent to the incorporation by
  reference  in this  registration  statement  of our  report  dated May 6, 1997
  included in  Molecular  Biosystems,  Inc.'s Form 10-K for the year ended March
  31,  1997 and to all  references  to our Firm  included  in this  registration
  statement.

                                                             Arthur Andersen LLP


  San Diego, California
  September 12, 1997



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