MOLECULAR BIOSYSTEMS INC
S-8, 1999-10-05
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM S-8

             Registration Statement under the Securities Act of 1933


                           MOLECULAR BIOSYSTEMS, INC.
             (Exact name of Registrant as specified in its charter)

                                    Delaware
                                   36-3078632
                  (State or other jurisdiction (I.R.S. Employer
            of incorporation or organization) Identification Number)

                            10030 Barnes Canyon Road
                           San Diego, California 92121
                    (Address of principal executive offices)

                           Molecular Biosystems, Inc.
                             1998 Stock Option Plan
                            (Full title of the plan)

                                Bobba Venkatadri
                      President and Chief Executive Officer
                           Molecular Biosystems, Inc.
                            10030 Barnes Canyon Road
                           San Diego, California 92121
                                 (858) 812-7001
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)



 ------------------------- ---------------------- ----------------------
   Title of Securities         Amount To Be          Proposed Maximum
    To Be Registered            Registered            Offering Price
                                                       Per Share(1)
- -------------------------- ---------------------- ------------------------
- -------------------------- ---------------------- ------------------------
  Common Stock, par          2,000,000 shares              $1.59
  value $.01 per share
- -------------------------- ---------------------- ------------------------

- -------------------------- ----------------------
    Proposed Maximum             Amount of
   Aggregate Offering          Registration
        Price(1)                  Fee(1)
- -------------------------- ----------------------
- -------------------------- ----------------------
      $3,180,000.00               $963.64

- -------------------------- ----------------------

(1)  Computed pursuant to Rule 457(c), in accordance with Rule 457(h)(1), on the
     basis of the  average  of the high and low  sales  prices of a share of the
     Registrant's Common Stock reported on the New York Stock Exchange,  Inc. on
     September 30, 1999.




                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

Item 1.  Plan Information

         The  information  required by Item 1 is omitted from this  Registration
Statement in accordance with the Note to Part I of Form S-8.

Item 2.  Registrant Information and Employee Plan Annual Information

         The  information  required by Item 2 is omitted from this  Registration
Statement in accordance with the Note to Part I of Form S-8.


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference

         The Registrant incorporates by reference in this Registration Statement
the following  documents  which the Registrant has filed with the Securities and
Exchange Commission (the "Commission"):

         (a) the Annual Report on Form 10-K which the  Registrant  filed for the
         fiscal year ended March 31, 1999;

         (b)    the Annual Report on Form 10K/A, dated March 31, 1999 and filed
on July 29, 1999;

         (c) the Quarterly  Report on Form 10-Q which the  Registrant  filed for
         the quarterly period ended June 30, 1999;

         (d) the Current Report on Form 8-K, dated May 3, 1999, and filed on May
13, 1999;

         (e) the description of the  Registrant's  Common Stock,  par value $.01
         per share,  contained in the  Registration  Statement on Form 8-A which
         the  Registrant  filed  on July 9,  1984  (Registration  No.  2-83721),
         together with any amendment or report that the  Registrant may file for
         the purpose of updating this description.

         All documents that the Registrant files with the Commission pursuant to
Sections 13(a),  13(c),  14 or 15(d) of the Securities  Exchange Act of 1934, as
amended, after the filing of this Registration Statement but prior to the filing
of a post-effective  amendment (1) which indicates that all of the shares of the
Registrant's Common Stock covered by this Registration  Statement (the "Shares")
have been sold or (2) which deregisters all of the Shares then remaining unsold,
shall  be  deemed  to be  incorporated  by  reference  in and to be part of this
Registration Statement from their respective dates of filing.

         Any statement in a document  incorporated  or deemed to be incorporated
by reference in this  Registration  Statement  shall be deemed to be modified or
superseded to the extent that a statement in this Registration  Statement, or in
any  document  filed after the filing of this  Registration  Statement  which is
deemed to be incorporated by reference in this Registration Statement,  modifies
or supersedes the earlier statement. The earlier statement shall be deemed to be
incorporated in this Registration Statement only as so modified or superseded.

Item 4.  Description of Securities

         This item is not applicable.

Item 5.  Interests of Named Experts and Counsel

         The legality of the Shares is being passed upon for the  Registrant  by
Johnson and Colmar, 300 South Wacker Drive, Suite 1000, Chicago, Illinois 60606,
who serve as the Registrant's outside general counsel.

         Craig P.  Colmar,  who is a partner of Johnson and Colmar,  is also the
Company's Assistant Secretary.  Mr. Colmar owns of record and beneficially 1,000
shares of Common Stock,  and other  partners of Johnson and Colmar own of record
and beneficially a further 1,000 shares.  In addition,  Mr. Colmar holds options
to purchase 57,250 shares of the Registrant's  Common Stock. These stock options
were granted at option prices equal to the fair market value of the Registrant's
Common Stock on the dates of grant.

Item 6.  Indemnification of Directors and Officers

         Section 145 of the Delaware General  Corporation Law provides generally
that a person sued as a director,  officer,  employee or agent of a  corporation
may be  indemnified  by the  corporation  in  non-derivative  suits for expenses
(including attorneys' fees), judgments,  fines and amounts paid in settlement if
he or she acted in good faith and in a manner that he or she reasonably believed
to be in, or not opposed to, the  corporation's  best interests.  In the case of
criminal actions and  proceedings,  the person must also not have had reasonable
cause to  believe  that his or her  conduct  was  unlawful.  Indemnification  of
expenses is also  authorized  in  stockholder  derivative  actions if the person
acted in good faith and in a manner that he or she reasonably believed to be in,
or not opposed to, the  corporation's  best  interests  and if he or she has not
been found liable to the corporation.  Even in this latter  instance,  the court
may determine that in view of all of the circumstances the person is entitled to
indemnification  for such expenses as the court deems proper. A person sued as a
director, officer, employee or agent of a corporation who has been successful in
defense of the action must be indemnified by the corporation  against his or her
expenses.

         Article  11  of  the  Registrant's  certificate  of  incorporation,  as
amended, requires the Registrant to indemnify its directors, officers, employees
and agents to the maximum  extent  permitted  by Delaware  law.  Article 11 also
requires  the  Registrant  to advance the  litigation  expenses of a director or
officer  upon  receipt of his or her  written  undertaking  to repay all amounts
advanced  if it is  ultimately  determined  that  he or she is not  entitled  to
indemnification.

         Section  102(b)(7) of the Delaware  General  Corporation  Law permits a
Delaware  corporation to include a provision in its certificate of incorporation
eliminating or limiting the personal  liability of a director to the corporation
or its  stockholders  for monetary  damages for breach of the director's duty of
care.  Such a provision  may not  eliminate or limit the liability of a director
for breaching his or her duty of loyalty, failing to act in good faith, engaging
in  intentional  misconduct or knowingly  violating a law,  declaring an illegal
dividend or  approving  an illegal  stock  repurchase,  or obtaining an improper
personal benefit.

         Article  10  of  the  Registrant's  certificate  of  incorporation,  as
amended,  eliminates the personal liability of the Registrant's directors to the
fullest extent permitted by Delaware law.

         Through  directors'  and  officers'   liability   insurance  which  the
Registrant maintains,  the Registrant's  directors and officers are also insured
against actual liabilities,  including  liabilities under the federal securities
laws, for acts or omissions related to the conduct of their duties.

Item 7.  Exemption from Registration Claimed

         This item is not applicable.

Item 8.  Exhibits

        4.1     Molecular Biosystems, Inc. 1998 Stock Option Plan

        5.1     Opinion of Johnson and Colmar

       23.1     Consent of Arthur Andersen LLP

       23.2     Consent of Johnson and Colmar (filed as part of Exhibit 5.1)

       24.1     Power of attorney (included under the caption "Power of Attorney
" on page 7).
Item 9.  Undertakings

Rule 415 Offering

         The Registrant undertakes:

                (1) to file,  during  any  period  in which  offers or sales are
         being made, a post-effective amendment to this Registration Statement:

                      (a) to include any prospectus required by Section 10(a)(3)
                of the  Securities  Act of 1933,  as  amended  (the  "Securities
                Act");

                      (b) to  reflect  in the  prospectus  any  facts or  events
                arising after the effective date of this Registration  Statement
                (or   the   most   recent   post-effective   amendment)   which,
                individually or in the aggregate, represent a fundamental change
                in the information set forth in this Registration Statement; and

                      (c) to include any  material  information  with respect to
                the  plan  of  distribution  not  previously  disclosed  in this
                Registration   Statement   or  any   material   change  to  such
                information in this Registration Statement;

         provided,  however, that undertakings (1)(a) and (1)(b) shall not apply
         if  the  information  required  to  be  included  in  a  post-effective
         amendment by those  undertakings is contained in periodic reports filed
         with or  furnished  to the  Commission  by the  Registrant  pursuant to
         Section 13 or Section 15(d) of the Securities  Exchange Act of 1934, as
         amended (the  "Exchange  Act") which are  incorporated  by reference in
         this Registration Statement;

                (2) that, for the purpose of determining any liability under the
         Securities Act, each such  post-effective  amendment shall be deemed to
         be a new  registration  statement  relating to the  securities  offered
         therein,  and the  offering  of such  securities  at that time shall be
         deemed to be the initial bona fide offering thereof; and

                (3) to remove  from  registration  by means of a  post-effective
         amendment any of the securities being registered which remain unsold at
         the termination of the offering; and

Filings Incorporating Subsequent Exchange Act Documents by Reference

         The  Registrant  undertakes  that,  for  purposes  of  determining  any
liability  under the  Securities  Act,  each filing of the  Registrant's  annual
report  pursuant to Section  13(a) or Section 15(d) of the Exchange Act which is
incorporated by reference in this Registration Statement shall be deemed to be a
new registration  statement relating to the securities offered therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

Commission Position on Indemnification

         Insofar as indemnification for liabilities arising under the Securities
Act may be  permitted to  directors,  officers  and  controlling  persons of the
Registrant  pursuant to the Delaware General Corporation Law or the Registrant's
certificate of incorporation,  as amended,  as described in Item 6, or otherwise
permitted, the Registrant has been advised that in the opinion of the Commission
such indemnification is against public policy as expressed in the Securities Act
and is, therefore,  unenforceable. In the event that a claim for indemnification
against such  liabilities  (other than the payment by the Registrant of expenses
incurred or paid by a director,  officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or  controlling  person in  connection  with the Shares,  the
Registrant  will,  unless in the  opinion  of its  counsel  the  matter has been
settled by controlling precedent,  submit to a court of appropriate jurisdiction
the question  whether such  indemnification  by it is against  public  policy as
expressed in the Securities  Act and will be governed by the final  adjudication
of such issue.


                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly authorized,  in the City of San Diego,  State of California,  on October 5,
1999.


                                       Molecular Biosystems, Inc.


                                       By:    /s/ ELIZABETH L. HOUGEN
                                              Elizabeth L. Hougen
                                              Executive Director of  Finance and
                                              Chief Financial Officer (Principal
                                              Financial and Accounting Officer)

<PAGE>

                                Power of Attorney

         Each person  whose  signature  appears  below who is then an officer or
director of the Registrant  authorizes Bobba Venkatadri and Elizabeth L. Hougen,
or either of them, with full power of substitution and  resubstitution,  to sign
in his name and to file any amendments (including  post-effective  amendments to
this Registration Statement) and all related documents necessary or advisable to
enable the Registrant to comply with the Securities Act of 1933, as amended,  in
connection  with the  registration  of the securities  which are covered by this
Registration  Statement,   which  amendments  may  make  such  changes  in  this
Registration  Statement  (as  it may  be so  amended)  as  Bobba  Venkatadri  or
Elizabeth  L. Hougen,  or either of them,  may deem  appropriate,  and to do and
perform all other related acts and things necessary to be done.

         Pursuant to the requirements of the Securities Act of 1933, as amended,
this  Registration  Statement has been signed below by the following  persons in
the capacities and on the dates indicated.



NAME                        TITLE                                DATE

/s/BOBBA VENKATARDI         President, Chief Executive Officer   October 5, 1999
   Bobba Venkatardi         and a Director (Principal
                            Executive Officer)


/s/ELIZABETH L. HOUGEN      Executive Director of Finance and    October 5, 1999
   Elizabeth L. Hougen      Chief Financial Officer(Principal
                            Financial and Accounting Officer)


/s/DAVID W. BARRY M.D.      Director                             October 5, 1999
   David W. Barry M.D.


/s/ROBERT W. BRIGHTFELT     Director                             October 5, 1999
   Robert W. Brightfelt

/s/CHARLES C. EDWARDS M.D.  Director                             October 5, 1999
   Charles C. Edwards M.D.

/s/JERRY T. JACKSON         Director                             October 5, 1999
   Jerry T. Jackson

/s/GORDON C. LUCE           Director                             October 5, 1999
   Gordon C. Luce

/s/DAVID RUBINFIEN          Director                             October 5, 1999
   David Rubinfien



                                Index to Exhibits

- ------------------------------- ------------------------------------------------
Exhibit Number      Description
- -------------------------------------------------------------------------------

4.1                 Molecular Biosystems, Inc. 1998 Stock Option Plan

5.1                 Opinion of Johnson and Colmar

23.1                Consent of Arthur Andersen LLP

23.2                Consent of Johnson and Colmar (filed as part of Exhibit 5.1)

24.1                Power of Attorney (included under the caption "Power of
                    Attorney" on page 7).







        Exhibit 4.1


                           MOLECULAR BIOSYSTEMS, INC.
                             1998 STOCK OPTION PLAN

                        (As Amended and Restated through
                               September 22, 1998)


                                   ARTICLE ONE

                               GENERAL PROVISIONS


       I.         PURPOSE OF THE PLAN


                  This  1998  Stock  Option  Plan is  intended  to  promote  the
interests of Molecular Biosystems,  Inc., a Delaware  corporation,  by providing
eligible  persons with the  opportunity  to acquire a proprietary  interest,  or
otherwise  increase  their  proprietary  interest,  in  the  Corporation  as  an
incentive for them to remain in the service of the Corporation.

                  Capitalized  terms  shall have the  meanings  assigned to such
terms in the attached Appendix.

      II.         STRUCTURE OF THE PLAN

                  A.       The Plan shall be divided into four separate equity
programs:

                                 (i)        the  Discretionary  Option Grant
Program under which  eligible  persons may, at the discretion of the Plan
Administrator, be granted options to purchase shares of Common Stock,

                                (ii) the Salary  Investment Option Grant Program
under which eligible employees may elect to have a portion of their base salary
invested each year in special options,

                               (iii)  the Stock  Issuance  Program  under  which
eligible persons may, at the discretion of the Plan Administrator, be issued
shares of Common Stock directly, either through the immediate  purchase of such
shares or as a bonus for services rendered the Corporation (or any Parent or
Subsidiary), and

                                (iv) the  Automatic  Option Grant  Program under
which eligible non-employee
Board  members  shall  automatically  receive  options at periodic  intervals to
purchase shares of Common Stock.

                  B. The  provisions  of Articles One and Six shall apply to all
equity  programs  under the Plan and shall  govern the  interests of all persons
under the Plan.


     III.         ADMINISTRATION OF THE PLAN

                  A.       The following provisions shall govern the
administration of the Plan:

                                 (i)        The Board shall have the  authority
to  administer  the  Discretionary
Option Grant and Stock Issuance Programs with respect to Section 16 Insiders but
may delegate such authority in whole or in part to the Primary Committee.

                                (ii)       Administration  of the Discretionary
Option Grant and Stock  Issuance
Programs  with respect to all other  persons  eligible to  participate  in those
programs may, at the Board's discretion, be vested in the Primary Committee or a
Secondary  Committee,  or the Board may  retain  the power to  administer  those
programs with respect to all such persons.

                               (iii) The Primary  Committee  shall have the sole
and exclusive authority to
determine which Section 16 Insiders and other highly compensated Employees shall
be eligible for  participation in the Salary Investment Option Grant Program for
one or more  calendar  years.  However,  all  option  grants  under  the  Salary
Investment  Option Grant Program  shall be made in  accordance  with the express
terms  of that  program,  and the  Primary  Committee  shall  not  exercise  any
discretionary  functions  with  respect  to the  option  grants  made under that
program.

                                (iv)        Administration   of  the  Automatic
Option  Grant  Program  shall  be self-executing in accordance with the terms of
that program.

                  B.  Each Plan  Administrator  shall,  within  the scope of its
administrative  jurisdiction  under the  Plan,  have  full  power and  authority
subject to the provisions of the Plan:

                                 (i)        to  establish  such  rules  as  it
may  deem  appropriate  for  proper administration of the Plan, to make all
factual determinations,  to construe and interpret the  provisions of the Plan
and the awards  thereunder  and to resolve
any and all ambiguities thereunder;

                                (ii)        to  determine,  with  respect to
awards  made  under the Discretionary Option Grant and Stock Issuance Programs,
which eligible persons are to receive such  awards,  the time or times when such
awards are to be made,  the number of shares  to be  covered  by each  such
award,  the  vesting  schedule  (if  any)
applicable to the award,  the status of a granted  option as either an Incentive
Option or a Non-Statutory Option and the maximum term for which the option is to
remain outstanding;

                               (iii)        to amend,  modify or cancel any
outstanding  award with the consent of the holder or accelerate the vesting of
such award; and

                                (iv)        to take such other  discretionary
actions as permitted pursuant to the terms of the applicable program.

Decisions  of each Plan  Administrator  within  the scope of its  administrative
functions under the Plan shall be final and binding on all parties.

                  C. Members of the Primary Committee or any Secondary Committee
shall  serve  for such  period of time as the  Board  may  determine  and may be
removed by the Board at any time.  The Board may also at any time  terminate the
functions of any  Secondary  Committee  and  reassume  all powers and  authority
previously delegated to such committee.

                  D. Service on the Primary Committee or the Secondary Committee
shall constitute  service as a Board member,  and members of each such committee
shall accordingly be entitled to full indemnification and reimbursement as Board
members for their service on such committee.  No member of the Primary Committee
or the Secondary  Committee shall be liable for any act or omission made in good
faith with respect to the Plan or any options or stock issuances under the Plan.

      IV.         ELIGIBILITY

                  A.       The  persons  eligible  to  participate  in the
Discretionary  Option  Grant  and Stock Issuance Programs are as follows:

                                 (i)        Employees,

                                (ii)        non-employee  members  of the Board
or the board of  directors of any Parent or Subsidiary, and

                               (iii)        consultants  and  other  independent
advisors  who provide services to the Corporation (or any Parent or Subsidiary).

                  B. Only  Employees who are Section 16 Insiders or other highly
compensated   individuals  shall  be  eligible  to  participate  in  the  Salary
Investment Option Grant Program.

                  C.  Only  non-employee  Board  members  shall be  eligible  to
participate in the Automatic Option Grant Program.

       V.         STOCK SUBJECT TO THE PLAN

                  A. The  stock  issuable  under  the Plan  shall be  shares  of
authorized but unissued or reacquired Common Stock, including shares repurchased
by the  Corporation  on the open market.  The maximum number of shares of Common
Stock initially reserved for issuance over the term of the Plan shall not exceed
the number of shares authorized under the Predecessor Plans being subsumed under
this Plan plus Two Million  (2,000,000)  shares  newly  authorized  by the Board
subject to stockholder  approval.  There are  approximately  Four Hundred Eighty
Eight Thousand  (488,000) shares which are authorized but not yet subject to any
outstanding option under the Predecessor  Plans.  There are approximately  Three
Million One Hundred Thousand (3,100,000) shares authorized under the Predecessor
Plans which are subject to currently outstanding option grants.

                  B.  No one  person  participating  in  the  Plan  may  receive
options,  separately  exercisable  stock  appreciation  rights and direct  stock
issuances  for more than Six  Hundred  and Fifty  Thousand  (650,000)  shares of
Common  Stock  in the  aggregate  per  calendar  year,  beginning  with the 1998
calendar year.

                  C.  Shares of Common  Stock  subject  to  outstanding  options
(including options incorporated into this Plan from the Predecessor Plans) shall
be available for subsequent  issuance under the Plan to the extent those options
expire,  terminate  or are  cancelled  for any reason prior to exercise in full.
Unvested  shares  issued  under  the Plan and  subsequently  repurchased  by the
Corporation, at the original exercise or issue price paid per share, pursuant to
the  Corporation's  repurchase  rights under the Plan shall be added back to the
number of shares of Common Stock  reserved for issuance under the Plan and shall
accordingly be available for reissuance  through one or more subsequent  options
or direct stock issuances under the Plan. However,  should the exercise price of
an option under the Plan be paid with shares of Common Stock or should shares of
Common Stock otherwise issuable under the Plan be withheld by the Corporation in
satisfaction of the  withholding  taxes incurred in connection with the exercise
of an option or the vesting of a stock issuance under the Plan,  then the number
of shares of Common Stock available for issuance under the Plan shall be reduced
by the gross  number of shares for which the option is  exercised  or which vest
under the stock  issuance,  and not by the net number of shares of Common  Stock
issued to the holder of such option or stock  issuance.  Shares of Common  Stock
underlying one or more stock appreciation  rights exercised under the Plan shall
not be available for subsequent issuance.

                  D. If any change is made to the Common  Stock by reason of any
stock split, stock dividend,  recapitalization,  combination of shares, exchange
of shares or other  change  affecting  the  outstanding  Common Stock as a class
without the  Corporation's  receipt of  consideration,  appropriate  adjustments
shall be made to (i) the maximum  number  and/or  class of  securities  issuable
under the Plan,  (ii) the number  and/or class of  securities by which the share
reserve is to  increase  each  calendar  year  pursuant to the  automatic  share
increase provisions of the Plan, (iii) the number and/or class of securities for
which any one  person  may be  granted  options,  separately  exercisable  stock
appreciation rights and direct stock issuances under the Plan per calendar year,
(iv) the number and/or class of securities for which grants are  subsequently to
be  made  under  the  Automatic  Option  Grant  Program  to new  and  continuing
non-employee  Board members,  (iv) the number and/or class of securities and the
exercise price per share in effect under each outstanding  option under the Plan
and (v) the  number  and/or  class of  securities  and price per share in effect
under each outstanding  option  incorporated into this Plan from the Predecessor
Plans.  Such  adjustments  to the  outstanding  options  are to be effected in a
manner which shall  preclude the  enlargement or dilution of rights and benefits
under such options.  The adjustments  determined by the Plan Administrator shall
be final, binding and conclusive.


<PAGE>



                                   ARTICLE TWO

                       DISCRETIONARY OPTION GRANT PROGRAM

       I.         OPTION TERMS


                  Each option shall be evidenced by one or more documents in the
form  approved  by the Plan  Administrator;  provided,  however,  that each such
document shall comply with the terms specified below.  Each document  evidencing
an Incentive Option shall, in addition, be subject to the provisions of the Plan
applicable to such options.

                  A.       Exercise Price.

                           1.       The exercise  price per share shall be fixed
by the Plan  Administrator  at the time of the option grant,  but in no event
shall the exercise price per share be less than one  eighty-five  percent (85%)
of the fair market value of the common stock on the date of grant.

2.      The exercise  price shall become immediately  due upon  exercise of the
option and shall, subject to the provisions of Section II of Article Six and the
documents evidencing the option, be payable in cash or check made payable to the
Corporation.  Should the Common Stock be registered under Section 12 of the 1934
Act at the time the option is  exercised,  then the  exercise  price may also be
paid as follows:

       (i)        shares  of  Common  Stock  held  for  the   requisite   period
         necessary to avoid a charge to the Corporation's earnings for financial
         reporting  purposes  and valued at Fair  Market  Value on the  Exercise
         Date, or

       (ii)       to the  extent  the option is  exercised  for  vested  shares,
         through a special sale and remittance  procedure  pursuant to which the
         Optionee shall concurrently  provide irrevocable  instructions to (a) a
         Corporation-approved brokerage firm to effect the immediate sale of the
         purchased shares and remit to the Corporation, out of the sale proceeds
         available  on the  settlement  date,  sufficient  funds  to  cover  the
         aggregate  exercise  price  payable for the  purchased  shares plus all
         applicable  Federal,  state  and  local  income  and  employment  taxes
         required to be withheld by the  Corporation  by reason of such exercise
         and (b) the Corporation to deliver the  certificates  for the purchased
         shares directly to such brokerage firm in order to complete the sale.

                  Except to the extent  such sale and  remittance  procedure  is
utilized, payment of the exercise price for the purchased shares must be made on
the Exercise Date.

                  B.  Exercise  and  Term  of  Options.  Each  option  shall  be
exercisable  at such time or times,  during  such  period and for such number of
shares as shall be  determined  by the Plan  Administrator  and set forth in the
documents evidencing the option.  However, no option shall have a term in excess
of ten (10) years measured from the option grant date.

                  C.       Cessation of Service.

1. The following provisions shall govern the exercise of any options outstanding
at the time of the Optionee's cessation of Service or death:

       (i)        Any  option   outstanding   at  the  time  of  the  Optionee's
         cessation of Service for any reason shall remain  exercisable  for such
         period  of  time   thereafter  as  shall  be  determined  by  the  Plan
         Administrator and set forth in the documents evidencing the option, but
         no such option shall be exercisable  after the expiration of the option
         term.

      (ii)        Any  option  exercisable  in whole or in part by the  Optionee
         at the time of death may be subsequently exercised by his or her
         Beneficiary.

     (iii)        During  the  applicable   post-Service  exercise  period,  the
         option may not be exercised in the  aggregate  for more than the number
         of vested shares for which the option is exercisable on the date of the
         Optionee's cessation of Service.  Upon the expiration of the applicable
         exercise period or (if earlier) upon the expiration of the option term,
         the option shall  terminate and cease to be outstanding  for any vested
         shares for which the option has not been exercised. However, the option
         shall, immediately upon the Optionee's cessation of Service,  terminate
         and cease to be  outstanding  to the extent the option is not otherwise
         at that time exercisable for vested shares.

      (iv)        Should the  Optionee's  Service be terminated  for  Misconduct
         or should the Optionee  engage in  Misconduct  while his or her options
         are outstanding,  then all such options shall terminate immediately and
         cease to be outstanding.

2.  The Plan Administrator shall have complete discretion, exercisable either at
the time an option is granted or at any time while the option remains
outstanding:

       (i)        to  extend  the  period  of time for  which  the  option is to
         remain  exercisable  following the  Optionee's  cessation of Service to
         such period of time as the Plan  Administrator  shall deem appropriate,
         but in no event beyond the expiration of the option term, and/or

      (ii)        to permit the option to be  exercised,  during the  applicable
         post-Service  exercise period, for one or more additional  installments
         in which the Optionee  would have vested had the Optionee  continued in
         Service.

                  D. Stockholder  Rights.  The holder of an option shall have no
stockholder  rights with respect to the shares  subject to the option until such
person shall have  exercised  the option,  paid the exercise  price and become a
holder of record of the purchased shares.

                  E. Repurchase Rights.  The Plan  Administrator  shall have the
discretion to grant options which are  exercisable for unvested shares of Common
Stock. Should the Optionee cease Service while holding such unvested shares, the
Corporation  shall have the right to repurchase,  at the exercise price paid per
share, any or all of those unvested shares. The terms upon which such repurchase
right shall be exercisable  (including the period and procedure for exercise and
the appropriate  vesting schedule for the purchased shares) shall be established
by the  Plan  Administrator  and  set  forth  in the  document  evidencing  such
repurchase right.

                  F. Limited  Transferability of Options. During the lifetime of
the Optionee,  Incentive  Options shall be exercisable  only by the Optionee and
shall not be  assignable  or  transferable  other than by will or by the laws of
descent and distribution  following the Optionee's death.  Non-Statutory Options
shall be subject to the same  restrictions,  except that a Non-Statutory  Option
may, to the extent permitted by the Plan Administrator,  be assigned in whole or
in part during the Optionee's  lifetime to one or more members of the Optionee's
immediate family or to a trust  established  exclusively for Optionee and/or one
or more such family members.  The terms applicable to the assigned portion shall
be the  same as  those  in  effect  for the  option  immediately  prior  to such
assignment  and shall be set forth in such  documents  issued to the assignee as
the Plan Administrator may deem appropriate.

      II.         INCENTIVE OPTIONS

                  The terms specified below shall be applicable to all Incentive
Options.  Except as  modified  by the  provisions  of this  Section  II, all the
provisions  of  Articles  One,  Two and Six  shall be  applicable  to  Incentive
Options. Options which are specifically designated as Non-Statutory Options when
issued under the Plan shall not be subject to the terms of this Section II.

                  A. Eligibility.  Incentive Options may only be granted to
Employees.

                  B. Exercise  Price.  The exercise price per share shall not be
less than eighty five percent (85%) of the Fair Market Value per share of Common
Stock on the option grant date.

                  C. Dollar  Limitation.  The aggregate Fair Market Value of the
shares of Common Stock  (determined as of the respective date or dates of grant)
for which one or more  options  granted to any  Employee  under the Plan (or any
other option plan of the  Corporation or any Parent or  Subsidiary)  may for the
first time become  exercisable as Incentive Options during any one calendar year
shall not exceed the sum of One  Hundred  Thousand  Dollars  ($100,000).  To the
extent the Employee holds two (2) or more such options which become  exercisable
for the first time in the same calendar  year,  the foregoing  limitation on the
exercisability  of such  options as  Incentive  Options  shall be applied on the
basis of the order in which such options are granted.

                  D.  10%  Stockholder.  If any  Employee  to whom an  Incentive
Option is granted is a 10% Stockholder,  then the exercise price per share shall
not be less than one  hundred ten  percent  (110%) of the Fair Market  Value per
share of Common  Stock on the option  grant date,  and the option term shall not
exceed five (5) years measured from the option grant date.

     III.         CHANGE IN CONTROL/HOSTILE TAKE-OVER

                  A. Each option  outstanding at the time of a Change in Control
but not otherwise fully-vested shall automatically  accelerate so that each such
option shall,  immediately prior to the effective date of the Change in Control,
become  exercisable for all of the shares of Common Stock at the time subject to
that option and may be exercised for any or all of those shares as  fully-vested
shares of Common Stock.  However,  an outstanding option shall not so accelerate
if and to the  extent:  (i) such  option  is, in  connection  with the Change in
Control,  assumed  or  otherwise  continued  in full  force  and  effect  by the
successor corporation (or parent thereof) pursuant to the terms of the Change in
Control,  (ii) such  option is  replaced  with a cash  incentive  program of the
successor  corporation  which  preserves the spread  existing at the time of the
Change in  Control  on the  shares of Common  Stock for which the  option is not
otherwise  at that  time  exercisable  and  provides  for  subsequent  payout in
accordance with the same vesting  schedule  applicable to those option shares or
(iii) the acceleration of such option is subject to other limitations imposed by
the Plan Administrator at the time of the option grant.

                  B. All  outstanding  repurchase  rights  shall also  terminate
automatically, and the shares of Common Stock subject to those terminated rights
shall immediately vest in full, in the event of any Change in Control, except to
the  extent:   (i)  those  repurchase  rights  are  assigned  to  the  successor
corporation (or parent  thereof) or otherwise  continue in full force and effect
pursuant to the terms of the Change in Control or (ii) such accelerated  vesting
is precluded by other limitations  imposed by the Plan Administrator at the time
the repurchase right is issued.

                  C.  Immediately  following the  consummation  of the Change in
Control,  all  outstanding  options shall terminate and cease to be outstanding,
except to the extent assumed by the successor corporation (or parent thereof) or
otherwise  expressly continued in full force and effect pursuant to the terms of
the Change in Control.

                  D. Each option which is assumed in connection with a Change in
Control  shall be  appropriately  adjusted,  immediately  after  such  Change in
Control,  to apply to the number and class of  securities  which would have been
issuable  to the  Optionee  in  consummation  of such  Change in Control had the
option been exercised  immediately prior to such Change in Control.  Appropriate
adjustments  to reflect  such  Change in  Control  shall also be made to (i) the
exercise  price payable per share under each  outstanding  option,  provided the
aggregate exercise price payable for such securities shall remain the same, (ii)
the maximum  number and/or class of  securities  available for issuance over the
remaining  term of the  Plan  and  (iii)  the  maximum  number  and/or  class of
securities  for  which  any  one  person  may  be  granted  options,  separately
exercisable stock appreciation  rights and direct stock issuances under the Plan
per calendar year.

                  E. The Plan  Administrator may at any time provide that one or
more  options  will  automatically  accelerate  in  connection  with a Change in
Control, whether or not those options are assumed or otherwise continued in full
force and effect pursuant to the terms of the Change in Control. Any such option
shall accordingly become exercisable, immediately prior to the effective date of
such  Change in  Control,  for all of the  shares  of  Common  Stock at the time
subject to that option and may be  exercised  for any or all of those  shares as
fully-vested shares of Common Stock. In addition,  the Plan Administrator may at
any time provide that one or more of the  Corporation's  repurchase rights shall
not be assignable in connection  with such Change in Control and shall terminate
upon the consummation of such Change in Control.

                  F. The Plan  Administrator may at any time provide that one or
more options will  automatically  accelerate upon an Involuntary  Termination of
the  Optionee's  Service within a designated  period (not to exceed  twenty-four
(24)  months)  following  the  effective  date of any Change in Control in which
those  options do not otherwise  accelerate.  Any options so  accelerated  shall
remain  exercisable  for  fully-vested  shares  until  the  earlier  of (i)  the
expiration of the option term or (ii) the  expiration of the one (1) year period
measured from the effective date of the  Involuntary  Termination.  In addition,
the  Plan  Administrator  may at any  time  provide  that  one  or  more  of the
Corporation's   repurchase   rights  shall   immediately   terminate  upon  such
Involuntary Termination.

                  G. The Plan  Administrator may at any time provide that one or
more  options  will  automatically  accelerate  in  connection  with  a  Hostile
Take-Over.  Any such option shall become  exercisable,  immediately prior to the
effective date of such Hostile Take-Over,  for all of the shares of Common Stock
at the time subject to that option and may be exercised  for any or all of those
shares  as  fully-vested   shares  of  Common  Stock.  In  addition,   the  Plan
Administrator  may at any time  provide  that  one or more of the  Corporation's
repurchase  rights shall terminate  automatically  upon the consummation of such
Hostile  Take-Over.  Alternatively,  the Plan  Administrator  may condition such
automatic  acceleration and termination  upon an Involuntary  Termination of the
Optionee's  Service within a designated  period (not to exceed  twenty-four (24)
months) following the effective date of such Hostile  Take-Over.  Each option so
accelerated  shall  remain   exercisable  for  fully-vested   shares  until  the
expiration or sooner termination of the option term.

                  H.  The  portion  of  any  Incentive  Option   accelerated  in
connection  with  a  Change  in  Control  or  Hostile  Take  Over  shall  remain
exercisable as an Incentive Option only to the extent the applicable One Hundred
Thousand Dollar ($100,000) limitation is not exceeded. To the extent such dollar
limitation  is  exceeded,  the  accelerated  portion  of such  option  shall  be
exercisable as a Non-Statutory Option under the Federal tax laws.

      IV.         STOCK APPRECIATION RIGHTS

                  The Plan  Administrator  may, subject to such conditions as it
may determine,  grant to selected Optionees stock appreciation rights which will
allow  the  holders  of  those  rights  to elect  between  the  exercise  of the
underlying option for shares of Common Stock and the surrender of that option in
exchange  for a  distribution  from the  Corporation  in an amount  equal to the
excess of (a) the Option  Surrender  Value of the number of shares for which the
option is  surrendered  over (b) the aggregate  exercise  price payable for such
shares.  The  distribution  may be made in shares of Common Stock valued at Fair
Market  Value on the option  surrender  date,  in cash,  or partly in shares and
partly in cash,  as the Plan  Administrator  shall in its sole  discretion  deem
appropriate.


<PAGE>



                                  ARTICLE THREE

                     SALARY INVESTMENT OPTION GRANT PROGRAM

       I.         OPTION GRANTS


<PAGE>




                  The Primary  Committee  may  implement  the Salary  Investment
Option Grant Program for one or more  calendar  years  beginning  after the Plan
Effective  Date and select the Section 16 Insiders and other highly  compensated
Employees  eligible to participate in the Salary Investment Option Grant Program
for each such calendar year. Each selected  individual who elects to participate
in the Salary  Investment  Option Grant Program must, prior to the start of each
calendar  year of  participation,  file  with  the  Plan  Administrator  (or its
designate) an irrevocable  authorization directing the Corporation to reduce his
or her base  salary  for  that  calendar  year by an  amount  not less  than Ten
Thousand  Dollars  ($10,000.00)  nor more  than  One  Hundred  Thousand  Dollars
($100,000.00). The Primary Committee shall have complete discretion to determine
whether to approve the filed  authorization  in whole or in part.  To the extent
the Primary Committee approves the authorization,  the individual who filed that
authorization  shall be granted  an option  under the  Salary  Investment  Grant
Program on the first  trading day in January for the calendar year for which the
salary reduction is to be in effect.

      II.         OPTION TERMS

                  Each option shall be a Non-Statutory  Option  evidenced by one
or more  documents  in the form  approved by the Plan  Administrator;  provided,
however, that each such document shall comply with the terms specified below.

                  A.       Exercise Price.

1. The exercise  price per share shall be Thirty-three Percent (33%) of the Fair
Market Value per share of Common Stock on the option grant date.

2. The exercise  price shall become immediately due upon  exercise of the option
and shall be payable in one or more of the alternative  forms  authorized  under
the  Discretionary  Option  Grant  Program.  Except to the  extent  the sale and
remittance procedure specified  thereunder is utilized,  payment of the exercise
price for the purchased shares must be made on the Exercise Date.

                  B.  Number of Option  Shares.  The  number of shares of Common
Stock  subject to the  option  shall be  determined  pursuant  to the  following
formula (rounded down to the nearest whole number):

                           X = A / (B x 67%), where

                           X is the number of option shares,

                           A is the dollar  amount of the approved  reduction in
                           the Optionee's base salary for the calendar year, and

                           B is the Fair Market  Value per share of Common Stock
on the option grant date.

                  C.  Exercise  and Term of  Options.  The option  shall  become
exercisable  in a series of twelve (12)  successive  equal monthly  installments
upon the Optionee's completion of each calendar month of Service in the calendar
year for which the salary  reduction  is in  effect.  Each  option  shall have a
maximum term of ten (10) years measured from the option grant date.

                  D. Cessation of Service.  Each option  outstanding at the time
of the Optionee's cessation of Service shall remain exercisable,  for any or all
of the shares for which the option is  exercisable at the time of such cessation
of Service,  until the earlier of (i) the  expiration of the option term or (ii)
the expiration of the three (3)-year period  following the Optionee's  cessation
of Service.  To the extent the option is held by the Optionee at the time of his
or her death,  the option may be exercised by his or her  Beneficiary.  However,
the  option  shall,  immediately  upon  the  Optionee's  cessation  of  Service,
terminate and cease to remain  outstanding with respect to any and all shares of
Common Stock for which the option is not otherwise at that time exercisable.

     III.         CHANGE IN CONTROL/HOSTILE TAKE-OVER

                  A. In the event of any Change in Control or Hostile  Take-Over
while  the  Optionee  remains  in  Service,   each   outstanding   option  shall
automatically  accelerate so that each such option shall,  immediately  prior to
the effective date of the Change in Control or Hostile  Take-Over,  become fully
exercisable  with  respect to the total  number of shares of Common Stock at the
time subject to such option and may be exercised  for any or all of those shares
as  fully-vested  shares  of  Common  Stock.  Each such  option  accelerated  in
connection  with a Change in Control shall terminate upon the Change in Control,
except to the extent assumed by the successor corporation (or parent thereof) or
otherwise continued in full force and effect pursuant to the terms of the Change
in Control.  Each such option accelerated in connection with a Hostile Take-Over
shall remain  exercisable  until the  expiration  or sooner  termination  of the
option term.

                  B. Upon the  occurrence of a Hostile  Take-Over,  the Optionee
shall have a thirty  (30)-day  period in which to surrender  to the  Corporation
each of his or her outstanding options. The Optionee shall in return be entitled
to a cash  distribution from the Corporation in an amount equal to the excess of
(i) the Option Surrender Value of the shares of Common Stock at the time subject
to each surrendered option (whether or not the Optionee is otherwise at the time
vested in those shares) over (ii) the aggregate  exercise price payable for such
shares.  Such cash distribution shall be paid within five (5) days following the
surrender of the option to the Corporation.

      IV.         REMAINING TERMS

                  The  remaining  terms of each option  granted under the Salary
Investment  Option  Grant  Program  shall be the same as the terms in effect for
options made under the Discretionary Option Grant Program.


<PAGE>



                                  ARTICLE FOUR

                             STOCK ISSUANCE PROGRAM

       I.         STOCK ISSUANCE TERMS


<PAGE>




                  Up to  Ten  percent  (10%)  of  the  shares  of  Common  Stock
available under the Plan may be issued under the Stock Issuance  Program without
any  intervening  options.  Shares of Common  Stock may also be issued under the
Stock  Issuance  Program  pursuant  to share  right  awards  which  entitle  the
recipients to receive those shares upon the attainment of designated performance
goals or Service requirements. Each such award shall be evidenced by one or more
documents which comply with the terms specified below.

                  A.       Purchase Price.

1. The purchase price per share of Common Stock subject to direct issuance shall
be fixed by the Plan Administrator, but in no event shall the price per share be
less than one  hundred  percent  (100%) of the fair  market  value of the common
stock on the date of issuance.

2. Subject to the provisions of Section II of Article Six, shares of Common
Stock may be issued under the Stock Issuance Program for any of the following
items of consideration  which  the  Plan  Administrator  may  deem  appropriate
in  each individual instance:

       (i)        cash or check made payable to the Corporation, or

      (ii)        past services  rendered to the  Corporation  (or any Parent or
         Subsidiary).

                  B.       Vesting/Issuance Provisions.

1. The Plan  Administrator  may issue shares of Common Stock which are fully and
immediately  vested  upon  issuance  or  which  are  to  vest  in  one  or  more
installments  over the  Participant's  period of Service or upon  attainment  of
specified  performance  objectives.  Alternatively,  the Plan  Administrator may
issue  share  right  awards  which  shall  entitle  the  recipient  to receive a
specified  number of vested shares of Common Stock upon the attainment of one or
more  performance  goals  or  Service  requirements   established  by  the  Plan
Administrator.

2. Any new, substituted or additional  securities or other  property  (including
money paid other than as a regular cash dividend) which the Participant may have
the right to receive with respect to his or her unvested  shares of Common Stock
by reason of any stock dividend, stock split,  recapitalization,  combination of
shares,  exchange of shares or other change  affecting  the  outstanding  Common
Stock as a class without the  Corporation's  receipt of  consideration  shall be
issued  subject  to  (i)  the  same  vesting  requirements   applicable  to  the
Participant's  unvested shares of Common Stock and (ii) such escrow arrangements
as the Plan Administrator shall deem appropriate.

3. The Participant shall have full stockholder rights with respect to the issued
shares of Common  Stock,  whether  or not the  Participant's  interest  in those
shares is vested. Accordingly, the Participant shall have the right to vote such
shares and to receive any regular cash dividends paid on such shares.

4. Should the Participant cease to remain in Service  while  holding one or more
unvested  shares of Common Stock,  or should the  performance  objectives not be
attained with respect to one or more such unvested shares of Common Stock,  then
those  shares  shall  be  immediately   surrendered  to  the   Corporation   for
cancellation,  and the Participant shall have no further stockholder rights with
respect to those shares.  To the extent the  surrendered  shares were previously
issued to the  Participant  for  consideration  paid in cash or cash  equivalent
(including the Participant's purchase-money indebtedness), the Corporation shall
repay to the Participant the cash  consideration paid for the surrendered shares
and shall cancel the unpaid principal balance of any outstanding  purchase-money
note of the Participant attributable to the surrendered shares.

5.The Plan Administrator may waive the surrender and cancellation of one or more
unvested  shares of Common Stock (or other assets  attributable  thereto)  which
would  otherwise  occur upon the cessation of the  Participant's  Service or the
non-attainment of the performance  objectives  applicable to those shares.  Such
waiver shall result in the immediate  vesting of the  Participant's  interest in
the shares of Common  Stock as to which the waiver  applies.  Such waiver may be
effected at any time,  whether  before or after the  Participant's  cessation of
Service  or the  attainment  or  non-attainment  of the  applicable  performance
objectives.

6.Outstanding share right awards shall automatically terminate, and no shares of
Common Stock shall actually be issued in  satisfaction  of those awards,  if the
performance  goals or Service  requirements  established for such awards are not
attained.  The Plan  Administrator,  however,  shall have the authority to issue
shares of Common Stock in  satisfaction of one or more  outstanding  share right
awards as to which the designated  performance goals or Service requirements are
not attained.

      II.         CHANGE IN CONTROL/HOSTILE TAKE-OVER

                  A.  All of the  Corporation's  outstanding  repurchase  rights
shall  terminate  automatically,  and all the shares of Common Stock  subject to
those  terminated  rights shall  immediately  vest in full,  in the event of any
Change in Control, except to the extent (i) those repurchase rights are assigned
to the successor  corporation (or parent thereof) or otherwise  continue in full
force and  effect  pursuant  to the terms of the  Change in Control or (ii) such
accelerated  vesting  is  precluded  by other  limitations  imposed  by the Plan
Administrator at the time the repurchase right is issued.

                  B. The Plan  Administrator  may at any  time  provide  for the
automatic termination of one or more of those outstanding  repurchase rights and
the immediate  vesting of the shares of Common Stock subject to those terminated
rights upon (i) a Change in Control or Hostile  Take-Over or (ii) an Involuntary
Termination  of the  Participant's  Service  within a designated  period (not to
exceed  twenty-four  (24) months)  following the effective date of any Change in
Control or Hostile  Take-Over in which those  repurchase  rights are assigned to
the  successor  corporation  (or parent  thereof) or otherwise  continue in full
force and effect.

     III.         SHARE ESCROW/LEGENDS

                  Unvested shares may, in the Plan  Administrator's  discretion,
be held in escrow by the Corporation  until the  Participant's  interest in such
shares  vests or may be issued  directly  to the  Participant  with  restrictive
legends on the certificates evidencing those unvested shares.


<PAGE>



                                  ARTICLE FIVE

                         AUTOMATIC OPTION GRANT PROGRAM


<PAGE>




       I.         OPTION TERMS

      A.       Grant Dates.  Options shall be made on the dates specified below:

1. Each  individual  who is first elected or  appointed as a  non-employee Board
member at any time after the Plan Effective Date shall automatically be granted,
on the date of such initial election or appointment,  a Non-Statutory  Option to
purchase  Fifteen  Thousand  (15,000)  shares of  Common  Stock,  provided  that
individual  has not  previously  been in the  employ of the  Corporation  or any
Parent or Subsidiary and is not a 5% Stockholder or Affiliate (the "Commencement
Grant").

2. On the date of each Annual Stockholders Meeting held after the Plan Effective
Date,  each  individual  who is to  continue  to serve as a  non-employee  Board
member, whether or not that individual is standing for re-election to the Board,
shall  automatically be granted a Non-Statutory  Option to purchase Six Thousand
Five Hundred (6,500) shares of Common Stock, provided such individual has served
as a  non-employee  Board  member  for at least six (6)  months  and is not a 5%
Stockholder or Affiliate (the "Annual Grant"), and provided that such individual
has not  received an automatic  option  grant under the Plan or the  Predecessor
Plans within the immediately preceding six month period.

                  B.       Exercise Price.

1. The exercise  price per share shall be equal to one hundred percent (100%) of
the Fair Market Value per share of Common Stock on the option grant date.

2. The  exercise  price shall be payable in one or more of the alternative forms
authorized under the  Discretionary  Option Grant Program.  Except to the extent
the sale and remittance procedure specified  thereunder is utilized,  payment of
the exercise price for the purchased shares must be made on the Exercise Date.

                  C.       Option Term.  Each option shall have a term of ten
(10) years  measured  from the option grant date.

                  D.  Exercise  and  Vesting of Options.  Each  option  shall be
immediately exercisable for any or all of the option shares. However, any shares
purchased under the option shall be subject to repurchase by the Corporation, at
the  exercise  price  paid per share,  upon the  Optionee's  cessation  of Board
service  prior to  vesting in those  shares.  Each  Commencement  Grant and each
Annual Grant shall vest, and the Corporation's  repurchase right shall lapse, at
the time of the next Annual Stockholders Meeting.

                  E. Cessation of Board Service.  The following provisions shall
govern the  exercise of any options  outstanding  at the time of the  Optionee's
cessation of Board service:

       (i)        Any  option   outstanding   at  the  time  of  the  Optionee's
         cessation of Board service for any reason shall remain  exercisable for
         a twelve  (12)-month  period  following  the date of such  cessation of
         Board service,  but in no event shall such option be exercisable  after
         the expiration of the option term.

      (ii)        Any  option  exercisable  in whole or in part by the  Optionee
         at the time of death may be subsequently exercised by his or her
         Beneficiary.

     (iii)        Following  the  Optionee's  cessation  of Board  service,  the
         option may not be exercised in the  aggregate  for more than the number
         of  shares  in  which  the  Optionee  was  vested  on the  date of such
         cessation  of Board  service.  Upon the  expiration  of the  applicable
         exercise period or (if earlier) upon the expiration of the option term,
         the option shall  terminate and cease to be outstanding  for any vested
         shares for which the option has not been exercised. However, the option
         shall,  immediately  upon the  Optionee's  cessation of Board  service,
         terminate and cease to be  outstanding  for any and all shares in which
         the Optionee is not otherwise at that time vested.

      (iv)        However,  should  the  Optionee  cease  to  serve  as a  Board
         member by reason of death or Permanent  Disability,  then all shares at
         the time  subject to the  option  shall  immediately  vest so that such
         option may, during the twelve (12)-month exercise period following such
         cessation  of Board  service,  be  exercised  for all or any portion of
         those shares as fully-vested shares of Common Stock.

      II.         CHANGE IN CONTROL/HOSTILE TAKE-OVER

                  A. In the event of any Change in Control or Hostile Take-Over,
the shares of Common  Stock at the time subject to each  outstanding  option but
not otherwise vested shall  automatically  vest in full so that each such option
may,  immediately  prior to the  effective  date of such  Change in Control  the
Hostile  Take-Over,  be  exercised  for all or any  portion  of those  shares as
fully-vested  shares of Common Stock. Each such option accelerated in connection
with a Change in Control shall  terminate upon the Change in Control,  except to
the extent assumed by the successor corporation (or parent thereof) or otherwise
continued  in full  force and  effect  pursuant  to the  terms of the  Change in
Control.  Each such option  accelerated in connection  with a Hostile  Take-Over
shall remain  exercisable  until the  expiration  or sooner  termination  of the
option term.

                  B. All  outstanding  repurchase  rights  shall also  terminate
automatically, and the shares of Common Stock subject to those terminated rights
shall immediately vest in full, in the event of any Change in Control or Hostile
Take-Over.

                  C. Upon the  occurrence of a Hostile  Take-Over,  the Optionee
shall have a thirty  (30)-day  period in which to surrender  to the  Corporation
each of his or her outstanding options. The Optionee shall in return be entitled
to a cash  distribution from the Corporation in an amount equal to the excess of
(i) the Option Surrender Value of the shares of Common Stock at the time subject
to each surrendered option (whether or not the Optionee is otherwise at the time
vested in those shares) over (ii) the aggregate  exercise price payable for such
shares.  Such cash distribution shall be paid within five (5) days following the
surrender of the option to the Corporation.

                  D. Each option which is assumed in connection with a Change in
Control  shall be  appropriately  adjusted  to apply to the  number and class of
securities  which would have been  issuable to the Optionee in  consummation  of
such Change in Control had the option been exercised  immediately  prior to such
Change in Control.  Appropriate  adjustments  shall also be made to the exercise
price payable per share under each  outstanding  option,  provided the aggregate
exercise price payable for such securities shall remain the same.

     III.         REMAINING TERMS

                  The remaining terms of each option granted under the Automatic
Option Grant  Program  shall be the same as the terms in effect for options made
under the Discretionary Option Grant Program.


<PAGE>



                                   ARTICLE SIX

                                  MISCELLANEOUS



<PAGE>



       I.         NO IMPAIRMENT OF AUTHORITY

                  Outstanding  awards  shall in no way  affect  the right of the
Corporation to adjust, reclassify, reorganize or otherwise change its capital or
business  structure  or to merge,  consolidate,  dissolve,  liquidate or sell or
transfer all or any part of its business or assets.

      II.         FINANCING

                  The Plan  Administrator may permit any Optionee or Participant
to pay the option exercise price under the Discretionary Option Grant Program or
the  purchase  price of  shares  issued  under  the Stock  Issuance  Program  by
delivering a full-recourse,  interest bearing  promissory note payable in one or
more installments. The terms of any such promissory note (including the interest
rate and the terms of repayment) shall be established by the Plan  Administrator
in its sole  discretion.  In no event may the maximum  credit  available  to the
Optionee or  Participant  exceed the sum of (i) the  aggregate  option  exercise
price or purchase price payable for the purchased  shares plus (ii) any Federal,
state and local income and employment tax liability  incurred by the Optionee or
the Participant in connection with the option exercise or share purchase.

     III.         TAX WITHHOLDING

                  A. The  Corporation's  obligation to deliver  shares of Common
Stock upon the  exercise  of options or the  issuance  or vesting of such shares
under the Plan shall be subject to the  satisfaction of all applicable  Federal,
state and local income and employment tax withholding requirements.

                  B. The Plan Administrator may, in its discretion,  provide any
or all holders of Non-Statutory Options or unvested shares of Common Stock under
the Plan with the right to use shares of Common Stock in  satisfaction of all or
part of the Taxes  incurred by such holders in  connection  with the exercise of
their options or the vesting of their shares.  Such right may be provided to any
such holder in either or both of the following formats:

Stock  Withholding:  The election to have the Corporation  withhold, from the
shares of Common Stock otherwise issuable upon the exercise of such
Non-Statutory  Option or the vesting of such shares,  a portion of those shares
with an aggregate Fair Market  Value  equal to the  percentage of the Taxes
(not to exceed one hundred percent (100%)) designated by the holder.

Stock  Delivery:  The election to deliver  to  the  Corporation, at the time the
Non-Statutory  Option is  exercised  or the shares  vest,  one or more shares of
Common Stock  previously  acquired by such holder (other than in connection with
the option  exercise or share  vesting  triggering  the Taxes) with an aggregate
Fair  Market  Value  equal to the  percentage  of the Taxes  (not to exceed  one
hundred percent (100%)) designated by the holder.

      IV.         EFFECTIVE DATE AND TERM OF THE PLAN

                  A. The Plan shall become  effective  immediately upon the Plan
Effective Date. However, the Salary Investment Option Grant Program shall not be
implemented  until  such  time as the  Primary  Committee  or the Board may deem
appropriate.  Options may be granted  under the  Discretionary  Option  Grant or
Automatic Option Grant Program at any time on or after the Plan Effective Date.

                  B. The Plan shall serve as the  successor  to the  Predecessor
Plans,  and no further options or direct stock issuances shall be made under the
Predecessor  Plans after the Plan Effective Date. All options  outstanding under
the Predecessor  Plans on the Plan Effective Date shall be incorporated into the
Plan at that time and shall be treated as  outstanding  options  under the Plan.
However,  each outstanding  option so incorporated shall continue to be governed
solely by the terms of the documents evidencing such option, and no provision of
the Plan shall be deemed to affect or otherwise modify the rights or obligations
of the holders of such incorporated options with respect to their acquisition of
shares of Common Stock.

                  C. One or more  provisions  of the  Plan,  including  (without
limitation) the option/vesting  acceleration  provisions of Article Two relating
to Changes in Control, may, in the Plan Administrator's  discretion, be extended
to one or more  options  incorporated  from the  Predecessor  Plans which do not
otherwise contain such provisions.

                  D. The Plan shall terminate upon the earliest of (i) the tenth
anniversary  of the Plan  Effective  Date,  (ii) the  date on which  all  shares
available  for  issuance  under the Plan shall have been issued as  fully-vested
shares or (iii) the termination of all outstanding  options in connection with a
Change in  Control.  Upon such plan  termination,  all  outstanding  options and
unvested stock issuances shall  thereafter  continue to have force and effect in
accordance  with the  provisions  of the  documents  evidencing  such  grants or
issuances.

       V.         AMENDMENT OF THE PLAN

                  A. The Board  shall  have  complete  and  exclusive  power and
authority to amend or modify the Plan in any or all respects.  However,  no such
amendment or modification shall adversely affect the rights and obligations with
respect to stock  options or unvested  stock  issuances at the time  outstanding
under the Plan unless the Optionee or the Participant consents to such amendment
or  modification.  In  addition,  certain  amendments  may  require  stockholder
approval pursuant to applicable laws or regulations.

                  B.  Options to purchase  shares of Common Stock may be granted
under the Discretionary Option Grant and Salary Investment Option Grant Programs
and shares of Common Stock may be issued under the Stock  Issuance  Program that
are in each  instance  in excess of the  number of  shares  then  available  for
issuance under the Plan,  provided any excess shares actually issued under those
programs shall be held in escrow until there is obtained stockholder approval of
an  amendment  sufficiently  increasing  the  number of  shares of Common  Stock
available  for  issuance  under the Plan.  If such  stockholder  approval is not
obtained  within  twelve  (12)  months  after  the date the  first  such  excess
issuances are made,  then (i) any  unexercised  options  granted on the basis of
such excess  shares shall  terminate  and cease to be  outstanding  and (ii) the
Corporation  shall  promptly  refund to the Optionees and the  Participants  the
exercise or purchase  price paid for any excess shares issued under the Plan and
held in escrow,  together  with interest (at the  applicable  Short Term Federal
Rate) for the period  the shares  were held in  escrow,  and such  shares  shall
thereupon be automatically cancelled and cease to be outstanding.

      VI.         USE OF PROCEEDS

                  Any cash proceeds received by the Corporation from the sale of
shares  of  Common  Stock  under the Plan  shall be used for  general  corporate
purposes.

     VII.         REGULATORY APPROVALS

                  A. The  implementation  of the Plan, the granting of any stock
option  under the Plan and the  issuance of any shares of Common  Stock (i) upon
the  exercise of any  granted  option or (ii) under the Stock  Issuance  Program
shall be subject to the  Corporation's  procurement of all approvals and permits
required by regulatory  authorities having jurisdiction over the Plan, the stock
options granted under it and the shares of Common Stock issued pursuant to it.

                  B. No shares of Common  Stock or other  assets shall be issued
or  delivered  under the Plan unless and until there shall have been  compliance
with all applicable requirements of Federal and state securities laws, including
the filing and  effectiveness  of the Form S-8  registration  statement  for the
shares of Common  Stock  issuable  under the Plan,  and all  applicable  listing
requirements  of  any  stock  exchange  (or  the  Nasdaq  National  Market,   if
applicable) on which Common Stock is then listed for trading.

    VIII.         NO EMPLOYMENT/SERVICE RIGHTS

                  Nothing  in the Plan shall  confer  upon the  Optionee  or the
Participant any right to continue in Service for any period of specific duration
or interfere with or otherwise restrict in any way the rights of the Corporation
(or any Parent or  Subsidiary  employing  or  retaining  such  person) or of the
Optionee or the Participant, which rights are hereby expressly reserved by each,
to terminate such person's  Service at any time for any reason,  with or without
cause.


<PAGE>



33

                                    APPENDIX


                  The following definitions shall be in effect under the Plan:

         A. Automatic Option Grant Program shall mean the automatic option grant
program in effect under the Plan.

         B.  Beneficiary  shall  mean,  in  the  event  the  Plan  Administrator
implements a  beneficiary  designation  procedure,  the person  designated by an
Optionee or Participant, pursuant to such procedure, to succeed to such person's
rights under any outstanding  awards held by him or her at the time of death. In
the absence of such  designation  or  procedure,  the  Beneficiary  shall be the
personal  representative  of the estate of the  Optionee or  Participant  or the
person  or  persons  to whom  the  award is  transferred  by will or the laws of
descent and distribution.

         C.       Board shall mean the Corporation's Board of Directors.

         D. Change in Control shall mean a change in ownership or control of the
Corporation effected through any of the following transactions:

                        (i) a merger,  consolidation or reorganization  approved
         by the Corporation's stockholders,  unless securities representing more
         than fifty  percent  (50%) of the total  combined  voting  power of the
         voting   securities  of  the  successor   corporation  are  immediately
         thereafter   beneficially   owned,   directly  or  indirectly   and  in
         substantially  the same  proportion,  by the persons  who  beneficially
         owned the Corporation's outstanding voting securities immediately prior
         to such transaction,
                       (ii) any  stockholder-approved transfer or other
         disposition of all or substantially all of the Corporation's assets, or

                      (iii)  the  acquisition,  directly  or  indirectly  by any
         person or related  group of persons  (other than the  Corporation  or a
         person that directly or indirectly  controls,  is controlled  by, or is
         under common control with, the  Corporation),  of beneficial  ownership
         (within  the  meaning  of Rule  13d-3  of the 1934  Act) of  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities pursuant to a tender
         or exchange offer made directly to the Corporation's stockholders which
         the Board recommends such stockholders accept.

         E.       Code shall mean the Internal Revenue Code of 1986, as amended.

         F.       Common Stock shall mean the Corporation's common stock.

         G.       Corporation shall mean Molecular Biosystems, Inc., a Delaware
corporation, and its successors.

         H.  Discretionary  Option Grant  Program  shall mean the  discretionary
option grant program in effect under the Plan.

         I.  Employee  shall  mean an  individual  who is in the  employ  of the
Corporation (or any Parent or Subsidiary),  subject to the control and direction
of the employer  entity as to both the work to be  performed  and the manner and
method of performance.

         J.  Exercise  Date shall mean the date on which the  Corporation  shall
have received written notice of the option exercise.

         K. Fair Market  Value per share of Common  Stock on any  relevant  date
shall be determined in accordance with the following provisions:

                        (i) If the  Common  Stock is at the time  traded  on the
         Nasdaq National Market, then the Fair Market Value shall be the closing
         selling  price per share of Common  Stock on the date in  question,  as
         such price is reported on the Nasdaq  National  Market or any successor
         system.  If there is no closing  selling  price for the Common Stock on
         the date in  question,  then the Fair Market Value shall be the closing
         selling  price on the last  preceding  date for  which  such  quotation
         exists.

                       (ii) If the  Common  Stock is at the time  listed  on any
         Stock Exchange, then the Fair Market Value shall be the closing selling
         price per share of Common  Stock on the date in  question  on the Stock
         Exchange  determined by the Plan Administrator to be the primary market
         for the  Common  Stock,  as such  price  is  officially  quoted  in the
         composite tape of transactions on such exchange. If there is no closing
         selling  price for the Common Stock on the date in  question,  then the
         Fair  Market  Value  shall  be the  closing  selling  price on the last
         preceding date for which such quotation exists.

         L. 5% Stockholder or Affiliate  shall mean a non-employee  Board member
who,  directly  or  indirectly,  owns stock (as  determined  under Code  Section
424(d)) possessing equal to or more than five percent (5%) of the total combined
voting power of the outstanding  securities of the Corporation (or any Parent or
Subsidiary) or is affiliated with or is a representative  of such a five percent
or greater stockholder.

         M.       Hostile Take-Over shall mean:

                        (i) the  acquisition,  directly  or  indirectly,  by any
         person or related  group of persons  (other than the  Corporation  or a
         person that directly or indirectly  controls,  is controlled  by, or is
         under common control with,  the  Corporation)  of beneficial  ownership
         (within  the  meaning  of Rule  13d-3  of the 1934  Act) of  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities pursuant to a tender
         or exchange offer made directly to the Corporation's stockholders which
         the Board does not recommend such stockholders to accept, or

                       (ii) a change  in the  composition  of the  Board  over a
         period  of  thirty-six  (36)  consecutive  months  or less  such that a
         majority  of the  Board  members  ceases,  by  reason  of  one or  more
         contested   elections  for  Board   membership,   to  be  comprised  of
         individuals who either (A) have been Board members  continuously  since
         the  beginning of such period or (B) have been elected or nominated for
         election as Board members  during such period by at least a majority of
         the Board  members  described in clause (A) who were still in office at
         the time the Board approved such election or nomination.

         N.       Incentive Option shall mean an option which satisfies the
requirements of Code Section 422.

         O.      Involuntary  Termination  shall  mean the  termination  of the
Service of any  individual  which occurs by reason of:

                        (i)         such   individual's   involuntary  dismissal
          or  discharge  by  Corporation for reasons other than Misconduct, or

                       (ii) such individual's  voluntary  resignation  following
         (A) a change in his or her position with the  Corporation  or Parent or
         Subsidiary employing the individual which materially reduces his or her
         duties and  responsibilities  or the level of management to which he or
         she  reports,  (B) a  reduction  in his or her  level  of  compensation
         (including  base  salary,  fringe  benefits  and target bonus under any
         performance  based bonus or  incentive  programs)  by more than fifteen
         percent  (15%)  or (C) a  relocation  of  such  individual's  place  of
         employment  by more than fifty (50)  miles,  provided  and only if such
         change,  reduction or relocation is effected by the Corporation without
         the individual's consent.

         P.  Misconduct   shall  mean  the  commission  of  any  act  of  fraud,
embezzlement or dishonesty by the Optionee or Participant,  any unauthorized use
or disclosure by such person of confidential information or trade secrets of the
Corporation (or any Parent or Subsidiary), or any intentional wrongdoing by such
person, whether by omission or commission,  which adversely affects the business
or  affairs  of the  Corporation  (or any  Parent or  Subsidiary)  in a material
manner.  This shall not limit the grounds for the  dismissal or discharge of any
person in the Service of the Corporation (or any Parent or Subsidiary).

         Q. 1934 Act shall mean the Securities Exchange Act of 1934, as amended.

         R. Non-Statutory  Option  shall mean an option not  intended  to
satisfy  the  requirements  of Code Section 422.

         S. Option Surrender Value shall mean the Fair Market Value per share of
Common Stock on the date the option is surrendered to the Corporation or, in the
event of a Hostile  Take-Over,  effected  through a tender  offer,  the  highest
reported price per share of Common Stock paid by the tender offeror in effecting
such Hostile  Take-Over,  if greater.  However,  if the surrendered option is an
Incentive  Option,  the Option  Surrender Value shall not exceed the Fair Market
Value per share.

         T.  Optionee  shall mean any person to whom an option is granted  under
the  Discretionary  Option Grant,  Salary  Investment  Option Grant or Automatic
Option Grant Program.

         U. Parent shall mean any corporation (other than the Corporation) in an
unbroken  chain of  corporations  ending  with the  Corporation,  provided  each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination,  stock possessing fifty percent (50%) or more of the total
combined  voting power of all classes of stock in one of the other  corporations
in such chain.

         V.  Participant  shall mean any  person who is issued  shares of Common
Stock under the Stock Issuance Program.

         W.  Permanent   Disability  or  Permanently  Disabled  shall  mean  the
inability  of the  Optionee  or the  Participant  to engage  in any  substantial
gainful  activity  by reason of any  medically  determinable  physical or mental
impairment expected to result in death or to be of continuous duration of twelve
(12) months or more. However,  solely for purposes of the Automatic Option Grant
Program,  Permanent  Disability or Permanently Disabled shall mean the inability
of the  non-employee  Board member to perform his or her usual duties as a Board
member by reason of any  medically  determinable  physical or mental  impairment
expected  to  result in death or to be of  continuous  duration  of twelve  (12)
months or more.

         X.       Plan shall mean the Corporation's 1998 Stock Option Plan, as
set forth in this document.

         Y. Plan  Administrator  shall mean the particular  entity,  whether the
Primary Committee, the Board or the Secondary Committee,  which is authorized to
administer the  Discretionary  Option Grant,  Salary Investment Option Grant and
Stock Issuance Programs with respect to one or more classes of eligible persons,
to the extent such entity is carrying  out its  administrative  functions  under
those programs with respect to the persons under its jurisdiction.  However, the
Primary  Committee  shall  have  the  plenary  authority  to  make  all  factual
determinations  and to construe and interpret any and all ambiguities  under the
Plan to the extent such  authority is not otherwise  expressly  delegated to any
other Plan Administrator.

         Z.       Plan  Effective  Date shall mean the date on which the Plan is
approved by the  shareholders  of the Corporation.

         AA.  Predecessor Plans shall mean the  Corporation's  pre-existing 1993
Stock Option Plan and 1997 Outside Directors' Stock Option Plan, in each case as
in effect immediately prior to the Plan Effective Date hereunder.

         BB.  Primary  Committee  shall  mean the  committee  of two (2) or more
non-employee   Board  members   appointed  by  the  Board  to   administer   the
Discretionary  Option Grant and Stock Issuance  Programs with respect to Section
16 Insiders and to administer  the Salary  Investment  Option Grant Program with
respect to all eligible individuals.

         CC.      Salary  Investment  Option Grant Program shall mean the salary
investment grant program in effect under the Plan.

         DD. Secondary Committee shall mean a committee of one (1) or more Board
members appointed by the Board to administer the Discretionary  Option Grant and
Stock Issuance  Programs with respect to eligible  persons other than Section 16
Insiders.

         EE.      Section  16  Insider  shall  mean an  officer  or  director
of the  Corporation  subject  to the short-swing profit liabilities of Section
16 of the 1934 Act.

         FF. Service shall mean the  performance of services for the Corporation
(or any Parent or  Subsidiary)  by a person in the  capacity of an  Employee,  a
non-employee  member of the board of directors or a  consultant  or  independent
advisor,  except to the extent otherwise  specifically provided in the documents
evidencing the option grant or stock issuance.

         GG.      Stock Exchange shall mean either the American Stock Exchange
or the New York Stock Exchange.

         HH.      Stock Issuance Program shall mean the stock issuance program
in effect under the Plan.

         II. Subsidiary shall mean any corporation  (other than the Corporation)
in an unbroken chain of corporations  beginning with the  Corporation,  provided
each corporation  (other than the last  corporation) in the unbroken chain owns,
at the time of the  determination,  stock possessing fifty percent (50%) or more
of the total  combined  voting power of all classes of stock in one of the other
corporations in such chain.

         JJ. Taxes shall mean the Federal, state and local income and employment
tax  liabilities  incurred  by the holder of  Non-Statutory  Options or unvested
shares of Common Stock in  connection  with the exercise of those options or the
vesting of those shares.

         KK.      10%  Stockholder  shall  mean the  owner of stock  (as
determined  under  Code  Section  424(d)) possessing  more  than ten  percent
(10%) of the  total  combined  voting  power  of all  classes  of stock of the
Corporation (or any Parent or Subsidiary).




Exhibit 5.1



September 27, 1999

Board of Directors
Molecular Biosystems, Inc.
10030 Barnes Canyon Road
San Diego, California 92121


                             Re:    Registration Statement on Form S-8 -
                                    1998 Directors Stock Option Plan

Gentlemen:

         We have acted as counsel to Molecular Biosystems,  Inc. (the "Company")
in connection  with the  preparation and filing with the Securities and Exchange
Commission  of  a  Registration   Statement  on  Form  S-8  (the   "Registration
Statement") for the  registration  under the Securities Act of 1933, as amended,
of 2,000,000 shares of the Company's Common Stock, par value $.01 per share (the
"Shares"),  to be issued upon the  exercise of options  granted or to be granted
under the  Discretionary  Option Grant Program,  Salary  Investment Option Grant
Program and Automatic Option Grant Program under the Molecular Biosystems,  Inc.
1998 Stock  Option  Plan (the  "Plan"),  or to be issued  pursuant  to the Stock
Issuance Program under the Plan.

         As such counsel, we have examined the Plan, the Registration Statement,
the Company's certificate of incorporation and by-laws, each as amended to date,
minutes  of  meetings  and  records of  proceedings  of the  Company's  Board of
Directors and stockholders,  and such other matters of fact and questions of law
as we have considered  necessary to form the basis of our opinion. In the course
of this  examination,  we have assumed the  genuineness of all  signatures,  the
authenticity of all documents and  certificates  submitted to us as originals by
representatives  of the Company,  public  officials and third  parties,  and the
conformity  to  and   authenticity   of  the  originals  of  all  documents  and
certificates submitted to us as copies.


<PAGE>




Board of Directors
September 27, 1999
Page Two


     On the basis of our examination, we are of the opinion that (i) the Company
has duly  authorized  and reserved the Shares for issuance  upon the exercise of
options  granted  or to be  granted  or under  the  Discretionary  Option  Grant
Program,  Salary  Investment  Option Grant  Program and  Automatic  Option Grant
Program under the Plan, or pursuant to the Stock Issuance Program under the Plan
and that (ii) when issued upon the exercise and in accordance  with the terms of
options granted or to be granted under the  Discretionary  Option Grant Program,
Salary  Investment  Option Grant Program or Automatic Option Grant Program under
the Plan  (including,  but not  limited  to,  the terms of payment of the option
price),  or pursuant to the Stock  Issuance  Program under the Plan,  the Shares
will be validly issued, fully paid and nonassessable.

         We consent to the use of our opinion as an exhibit to the  Registration
Statement.


                                                          Very truly yours,

                                                          /s/ JOHNSON AND COLMAR

                                                          Johnson and Colmar





Exhibit 23.1





                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


As independent  public  accountants,  we hereby consent to the  incorporation by
reference  in this  registration  statement  of our report  dated April 30, 1999
included in Molecular Biosystems,  Inc.'s Form 10-K for the year ended March 31,
1999 and to all references to our firm included in this registration statement.



                                                             ARTHUR ANDERSEN LLP


San Diego, California
September 27, 1999




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