CARDINAL HEALTH INC
SC 13D, 1995-09-05
DRUGS, PROPRIETARIES & DRUGGISTS' SUNDRIES
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                                  UNITED STATES
                        SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C.  20549



                                   SCHEDULE 13D



                    UNDER THE SECURITIES EXCHANGE ACT OF 1934



                       MEDICINE SHOPPE INTERNATIONAL, INC.              
                                (Name of Issuer) 



                         COMMON STOCK, $0.01 PAR VALUE                  
                          (Title of Class of Securities)


                                   584686109                            
                                  (CUSIP Number)




             1100 NORTH LINDBERGH BOULEVARD, ST. LOUIS, MISSOURI  63132  
                                 (314) 993-6000                         
          (Name, Address and Telephone Number of Person Authorized to
           Receive Notices and Communications)



                                  AUGUST 26, 1995                       
             (Date of Event which Requires Filing of this Statement)



         If the filing person has previously filed a statement on
         Schedule 13G to report the acquisition which is the subject of
         this Schedule 13D, and is filing this schedule because of Rule
         13d-1(b)(3) or (4), check the following box / /.

         Check the following box if a fee is being paid with the
         statement /x/.








                                Page 1 of 11 Pages<PAGE>
         CUSIP NO.  584686109





                                    SCHEDULE 13D


         1.   NAME OF REPORTING PERSON
              SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Cardinal Health, Inc.
              31-0958666

         2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a) / /

                                                                  (b) / /

         3.   SEC USE ONLY

         4.   SOURCE OF FUNDS
              WC

         5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
              REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                 / /

         6.   CITIZENSHIP OR PLACE OF ORGANIZATION
              Ohio

         NUMBER OF                          7.  SOLE VOTING POWER
           SHARES                               0
         BENEFICIALLY
           OWNED BY                         8.  SHARED VOTING POWER
            EACH                                0
          REPORTING
            PERSON                          9.  SOLE DISPOSITIVE POWER
             WITH                               0

                                            10. SHARED DISPOSITIVE POWER
                                                0

         11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
              1,300,000 shares of Common Stock.

         12.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
              CERTAIN SHARES                                          / /

         13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 14.4%.
              Based upon 7,721,737 shares of Common Stock outstanding at
              August 24, 1995, as represented by Issuer, calculated
              pursuant to Rule 13d-3(d)(1).

         14.  TYPE OF REPORTING PERSON
              HC, CO







                                Page 2 of 11 Pages<PAGE>
         CUSIP NO.  584686109





         Item 1.   Security and Issuer.

                   This Schedule 13D relates to the common stock, $0.01 par
         value per share ("MSI Common Stock"), of Medicine Shoppe
         International, Inc. ("MSI"), a Delaware corporation.  The
         principal executive offices of MSI are located at 1100 North
         Lindbergh Boulevard, St. Louis, Missouri 63132.

         Item 2.   Identity and Background.

                   This Schedule 13D is filed by Cardinal Health, Inc.
         ("Cardinal"), an Ohio corporation.  Cardinal is a national, full-
         service wholesaler distributing a broad line of pharmaceuticals,
         surgical and hospital supplies, therapeutic plasma and other
         specialty pharmaceutical products, health and beauty care
         products, and other items sold by hospitals, retail drug stores,
         and other health care providers.  Cardinal's principal executive
         offices are located at 655 Metro Place South, Suite 925, Dublin,
         Ohio  43017.  

                   Each executive officer and each director of Cardinal is
         a citizen of the United States.  The name, business address and
         present principal occupation of each executive officer and
         director are set forth in Annex I to this Schedule 13D which is
         incorporated herein by this reference.

                   During the last five years, to the best of Cardinal's
         knowledge, neither Cardinal nor any of its executive officers or
         directors has been convicted in a criminal proceeding (excluding
         traffic violations or similar misdemeanors) or has been a party to
         a civil proceeding of a judicial or administrative body of
         competent jurisdiction as a result of which Cardinal or such
         person was or is subject to a judgment, decree or final order
         enjoining future violations of, or prohibiting or mandating
         activities subject to, federal or state securities laws, or
         finding any violation with respect to such laws, and which
         judgment, decree or final order was not subsequently vacated.

         Item 3.   Source and Amount of Funds or Other Consideration.

                   Pursuant to the Stock Option Agreement, dated August 26,
         1995, between Cardinal and MSI (the "Stock Option Agreement"), MSI
         granted Cardinal an irrevocable option (the "Option") to purchase,
         under certain circumstances and subject to certain adjustments, up
         to 1,300,000 authorized and unissued shares of MSI Common Stock,
         at a price of $39.00 per share, payable in cash.  The shares of
         MSI Common Stock subject to the Option would equal 16.8% of the
         outstanding MSI Common Stock before giving effect to the exercise
         of the Option.  Under certain circumstances, MSI may be permitted
         to repurchase for cash the Option granted by it and any shares of
         MSI Common Stock acquired pursuant to the exercise of the Option.

                   The Option was granted by MSI as a condition of and in
         consideration for Cardinal entering into the Agreement and Plan of


                                Page 3 of 11 Pages<PAGE>
         CUSIP NO.  584686109





         Merger, dated August 26, 1995, among Cardinal, Arch Merger Corp.,
         a Delaware corporation and a wholly owned direct subsidiary of
         Cardinal ("Subcorp"), and MSI (the "Merger Agreement").

                   The exercise of the Option for the full number of shares
         currently covered thereby would require aggregate funds of
         $50,700,000.  It is anticipated that, should the Option become
         exercisable and should Cardinal determine to exercise the Option,
         Cardinal would obtain the funds for purchase from working capital
         or by borrowing from parties whose identity is not yet known.

                   A copy of the Stock Option Agreement is included as
         Exhibit 2.2 to this Schedule 13D and is incorporated herein by
         this reference.  The foregoing description of the Stock Option
         Agreement is qualified in its entirety by reference to such
         exhibit.

         Item 4.   Purpose of Transaction.

                   In connection with the execution of the Stock Option
         Agreement, Cardinal and MSI entered into the Merger Agreement,
         pursuant to which, among other matters and subject to the terms
         and conditions set forth in the Merger Agreement, Subcorp will
         merge (the "Merger") with and into MSI.  The Option was granted by
         MSI as a condition of and in consideration for Cardinal entering
         into the Merger Agreement.  Consummation of the Merger is subject
         to certain conditions, including:  (i) receipt of the approval of
         the Merger Agreement by the holders of a majority of the
         outstanding shares of MSI Common Stock; (ii) expiration or
         termination of all waiting periods applicable to the consummation
         of the Merger under the Hart-Scott-Rodino Antitrust Improvements
         Act of 1976, as amended; (iii) registration of the shares of
         Cardinal Common Stock to be issued in the Merger under the
         Securities Act of 1933, as amended; (iv) receipt of an opinion of
         counsel as to the tax-free nature of certain aspects of the
         Merger; (v) receipt of an accountant's letter confirming that the
         Merger will qualify as a pooling of interests transaction for
         financial reporting purposes; and (vi) satisfaction of certain
         other conditions.  Pursuant to the Merger Agreement, (a) the
         officers of the surviving corporation in the Merger will be the
         officers of MSI, (b) the directors of the surviving corporation in
         the Merger will be the directors of Subcorp, and (c) each share of
         MSI Common Stock will be converted into the right to receive a
         portion of a share of common stock, without par value, of Cardinal
         depending upon the market price of Cardinal common stock
         immediately prior to the closing date, plus cash in lieu of
         fractional shares.  Upon consummation of the Merger, the MSI
         Common Stock will be delisted from the NASDAQ National Market
         System.

                   A copy of the Merger Agreement is included as Exhibit
         2.1 to this Schedule 13D and is incorporated herein by this
         reference.  The foregoing description of the Merger Agreement is
         qualified in its entirety by reference to such exhibit.


                                Page 4 of 11 Pages<PAGE>
         CUSIP NO.  584686109





                   Except as set forth herein, Cardinal does not have any
         current plans or proposals that relate to or would result in (i)
         the acquisition by any person of additional shares of MSI Common
         Stock or the disposition of shares of MSI Common Stock; (ii) an
         extraordinary corporate transaction, such as a merger,
         reorganization or liquidation, involving MSI or any of its
         subsidiaries; (iii) a sale or transfer of any material amount of
         assets of MSI or any of its subsidiaries; (iv) any change in the
         present board of directors or management of MSI, including any
         plans or proposals to change the number or term of directors or to
         fill any vacancies on the board; (v) any material change in the
         present capitalization or dividend policy of MSI; (vi) any other
         material change in MSI's business or corporate structure; (vii)
         any change in MSI's charter or bylaws, or instruments
         corresponding thereto, or other actions that may impede the
         acquisition of control of MSI by any person; (viii) causing a
         class of securities of MSI to be delisted from a national
         securities exchange or to cease to be authorized to be quoted in
         an inter-dealer quotation system of a registered national
         securities association; (ix) a class of equity securities of MSI
         becoming eligible for termination of registration pursuant to
         Section 12(g)(4) of the Securities Exchange Act of 1934, as
         amended; or (x) any action similar to any of those enumerated
         above.

         Item 5.   Interest in Securities of Issuer.

                   Although the Option does not allow Cardinal to purchase
         any shares of MSI Common Stock pursuant thereto unless the
         conditions to exercise specified in the Stock Option Agreement
         occur, assuming for purposes of this Item 5 that such conditions
         are satisfied and Cardinal is entitled to purchase shares of MSI
         Common Stock pursuant to the Option, Cardinal would be entitled to
         purchase 1,300,000 shares of MSI Common Stock, or approximately
         14.4% of the outstanding MSI Common Stock after giving effect to
         the exercise of the Option.

                   Cardinal does not currently have the right to acquire
         any shares of MSI Common Stock under the Option unless certain
         events specified in the Stock Option Agreement occur.
         Accordingly, Cardinal does not have sole or shared voting or
         dispositive power with respect to any shares of MSI Common Stock,
         and Cardinal disclaims beneficial ownership of MSI Common Stock
         subject to the Option until such events occur.  Assuming for
         purposes of this Item 5 that events occurred that would enable
         Cardinal to exercise the Option and Cardinal exercised the Option,
         Cardinal would have sole voting power and sole dispositive power
         with respect to the shares acquired pursuant to the Option,
         subject to MSI's right to repurchase such shares as set forth in
         the Stock Option Agreement.

                   The foregoing description of certain terms of the Stock
         Option Agreement is qualified in its entirety by reference to the



                                Page 5 of 11 Pages<PAGE>
         CUSIP NO.  584686109





         Stock Option Agreement which is filed as Exhibit 2.2 hereto and
         which is incorporated herein by this reference.  

                   To the best of Cardinal's knowledge, no executive
         officer or director of Cardinal beneficially owns any shares of
         MSI Common Stock, nor (except for the issuance of the Option) have
         any transactions in MSI Common Stock been effected during the past
         60 days by Cardinal or, to the best knowledge of Cardinal, by any
         executive officer or director of Cardinal.  In addition, no other
         person is known by Cardinal to have the right to receive or the
         power to direct the receipt of dividends from, or the proceeds
         from the sale of, the securities covered by this Schedule 13D.

         Item 6.   Contracts, Arrangements, Understandings or Relationships
                   with Respect to Securities of the Issuer.             

                   Each of the persons set forth in Annex II to this
         Schedule 13D, which Annex II is incorporated herein by this
         reference, has entered into an agreement with Cardinal pursuant to
         which, among other matters, such person has agreed (i) to vote all
         of the shares of MSI Common Stock beneficially owned by such
         person or over which such person has voting power or control to
         approve the Merger and the Merger Agreement, (ii) not to vote such
         shares in favor of any other recapitalization, merger,
         consolidation or other business combination involving MSI, or
         acquisition of any capital stock or any material portion of the
         assets (except for acquisitions of assets in the ordinary course
         of business consistent with past practice) of MSI and (iii) not
         to, and not to permit any company, trust or other entity
         controlled by such person to, contract to sell, sell or otherwise
         transfer or dispose of any of such shares or any voting rights
         with respect thereto other than pursuant to the Merger without
         Cardinal's consent.  Such persons in the aggregate have voting
         power over approximately 16.7% of the outstanding shares of MSI
         Common Stock, based upon 7,721,737 shares of MSI Common Stock
         outstanding as of August 24, 1995, as represented by MSI.  A copy
         of the form of Support/Voting Agreement, dated as of August 26,
         1995, executed by such persons is included as Exhibit 99.1 to this
         Schedule 13D and is incorporated herein by this reference.  The
         foregoing description of the Support/Voting Agreement is qualified
         in its entirety by reference to such exhibit.

                   A copy of the Merger Agreement is included as Exhibit
         2.1 to this Schedule 13D and is incorporated herein by this
         reference.  See Item 4.

                   A copy of the Stock Option Agreement is included as
         Exhibit 2.2 to this Schedule 13D and is incorporated herein by
         this reference.  See Items 3 and 5.







                                Page 6 of 11 Pages<PAGE>
         CUSIP NO.  584686109





         Item 7.   Material to be Filed as Exhibits.

                   The following exhibits are filed as part of this
         Schedule 13D:

         Exhibit 2.1  --     Merger Agreement.

         Exhibit 2.2  --     Stock Option Agreement.

         Exhibit 99.1 --     Form of Support/Voting Agreement.














































                                Page 7 of 11 Pages<PAGE>
                 
                                                                    ANNEX I





                          Directors and Executive Officers

                   Set forth below are the name and present principal
         occupation of each director and executive officer of Cardinal
         Health, Inc. as of September 5, 1995.  Unless otherwise indicated
         below, the business address of each such director and executive
         officer is c/o Cardinal Health, Inc., 655 Metro Place South, Suite
         925, Dublin, Ohio 43017. 

         Name                     Principal Occupation            Address

         Directors
         of Cardinal
         Health, Inc.:

         John F. Finn             Chairman and Chief Executive
                                  Officer of Gardner, Inc., an
                                  outdoor power equipment dis-
                                  tributor.

         Robert L. Gerbig         President and Chief
                                  Executive Officer of
                                  Gerbig, Snell/Weisheimer
                                  & Associates, Inc., an 
                                  advertising agency.

         John F. Havens           Retired Chairman and Director
                                  Emeritus of Banc One Corpora-
                                  tion, a bank holding company. 

         Regina E. Herzlinger     Professor, Harvard University
                                  Graduate School of Business
                                  Administration.

         John C. Kane             President and Chief Operating
                                  Officer of Cardinal Health,
                                  Inc.

         George R. Manser         Chairman of Uniglobe 
                                  Travel (Capital Cities)
                                  Inc., a travel planning
                                  services company.

         John B. McCoy            Chairman and Chief Executive
                                  Officer of Banc One Corpora-
                                  tion, a bank holding company.

         Michael E. Moritz        Partner of Baker & Hostetler,
                                  a law firm.







                                Page 8 of 11 Pages<PAGE>





         Jerry E. Robertson       Retired Executive Vice
                                  President of the Life Sciences 
                                  Sector and Corporate Services
                                  of Minnesota Mining & Manu-
                                  facturing Company, a manu-
                                  facturer of industrial 
                                  commercial, health care and
                                  consumer products.

         L. Jack Van Fossen       Retired President and Chief
                                  Executive Officer of Red Roof
                                  Inns, Inc., a lodging company.

         Robert D. Walter         Chairman and Chief Executive
                                  Officer of Cardinal Health,
                                  Inc.

         Melburn G. Whitmire      Vice Chairman of Cardinal 
                                  Health, Inc.

         Executive Officers
         of Cardinal Health, Inc.
         (that are not directors):

         David Bearman            Executive Vice President and
                                  Chief Financial Officer.

         George H. Bennett, Jr.   Executive Vice President and 
                                  General Counsel.

         Anthony J. Campanaro     Executive Vice President-
                                  Central Group.

         James E. Clare           Executive Vice President- 103 WestPark
                                  Southern Group.           Drive, Suite E    
                                                            Peachtree City,
                                                            GA  30269

         Gary E. Close            Executive Vice President- 81 Blue Ravine
                                  Western Group.            Drive, Folsom,
                                                            CA  95630    

         Daniel P. Finkelman      Executive Vice President-
                                  Marketing.

         Phillip A. Greth         Executive Vice President 
                                  and Chief Information 
                                  Officer.

         James F. Millar          Executive Vice President-
                                  Northern Group.





                                Page 9 of 11 Pages<PAGE>
                             
                                                                ANNEX II





                     Persons Executing Support/Voting Agreements


         Aron Katzman

         Jeanne Katzman

         Donald P. Gallop

         Sue E. Gallop

         Judith F. Gall and Ira C. Gall, Trustees U/T/A 6/10/86, Ira C.
         Gall, Grantor

         Sanford S. Neuman, Trustee U/T/A 5/29/85, Gallop Family Trust

         Mitchelle Yanow

         Mitchelle Yanow, Personal Representative of the Estate of Elaine
         Yanow




































                               Page 10 of 11 Pages<PAGE>





                                       SIGNATURE

                   After reasonable inquiry and to the best of my knowledge
         and belief, I certify that the information set forth in this
         statement is true, complete and correct.

                                  CARDINAL HEALTH, INC.


                             By:  /s/    George H. Bennett, Jr.      
                                  Name:  George H. Bennett, Jr. 
                                  Title: Executive Vice President and
                                         General Counsel

         Dated:  September 5, 1995









































                               Page 11 of 11 Pages<PAGE>





                                    EXHIBIT INDEX

                                                       Sequential
         Exhibit   Description                         Page No.  

         2.1       Agreement and Plan of
                   Merger, dated August 26,
                   1995, among Cardinal Health, Inc.,
                   Arch Merger Corp. and Medicine
                   Shoppe International, Inc.

         2.2       Stock Option Agreement, dated
                   August 26, 1995, between
                   Cardinal Health, Inc. and Medicine
                   Shoppe International, Inc.

         99.1      Form of Support/Voting Agreement.









                           AGREEMENT AND PLAN OF MERGER

                                      AMONG

                              CARDINAL HEALTH, INC.
                                  ("CARDINAL"),

                                ARCH MERGER CORP.
                   A WHOLLY OWNED DIRECT SUBSIDIARY OF CARDINAL
                                   ("SUBCORP"),



                                       AND



                       MEDICINE SHOPPE INTERNATIONAL, INC.
                                     ("MSI")











                                 August 26, 1995<PAGE>







                                TABLE OF CONTENTS
                                                                    PAGE

         AGREEMENT AND PLAN OF MERGER.............................    1
         PRELIMINARY STATEMENTS...................................    1
         AGREEMENT................................................    1

         ARTICLE I:  THE MERGER...................................    2
              1.1    The Merger...................................    2
              1.2    Effective Time...............................    2
              1.3    Effects of the Merger........................    2
              1.4    Certificate of Incorporation and Bylaws......    2
              1.5    Directors and Officers.......................    3
              1.6    Additional Actions...........................    3


         ARTICLE II:  CONVERSION OF SECURITIES....................    3
              2.1    Conversion of Capital Stock..................    3
              2.2    Exchange of Certificates.....................    5
                     (a)  Exchange Agent..........................    5
                     (b)  Exchange Procedures.....................    5
                     (c)  Distributions with Respect to 
                            Unexchanged Shares....................    6
                     (d)  No Further Ownership Rights in 
                            MSI Common Stock......................    6
                     (e)  Termination of Exchange Fund............    7
                     (f)  No Liability............................    7
                     (g)  Investment of Exchange Fund.............    7
              2.3    Treatment of Stock Options and
                       Restricted Stock...........................    8

         ARTICLE III:  REPRESENTATIONS AND WARRANTIES OF 
                         CARDINAL AND SUBCORP.....................    9
              3.1    Organization and Standing....................    9
              3.2    Corporate Power and Authority................    9
              3.3    Capitalization of Cardinal...................    9
              3.4    Conflicts, Consents and Approval.............   10
              3.5    Brokerage and Finder's Fees..................   11
              3.6    Accounting Matters...........................   11
              3.7    Cardinal SEC Documents.......................   11
              3.8    Registration Statement.......................   12
              3.9    Compliance with Law..........................   13
              3.10   Litigation...................................   13
              3.11   State Takeover Laws..........................   13
              3.12   No Material Adverse Change...................   13

         ARTICLE IV:  REPRESENTATIONS AND WARRANTIES OF 
                        MSI.......................................   14
              4.1    Organization and Standing....................   14
              4.2    Subsidiaries.................................   14


                                       -i-<PAGE>





                                                                    PAGE

              4.3    Corporate Power and Authority................   15
              4.4    Capitalization of MSI........................   15
              4.5    Conflicts; Consents and Approvals............   16
              4.6    No Material Adverse Change...................   17
              4.7    MSI SEC Documents............................   17
              4.8    Taxes........................................   17
              4.9    Compliance with Law..........................   18
              4.10   Proprietary Rights...........................   18
              4.11   Title to and Condition of Properties.........   19
              4.12   Registration Statement.......................   19
              4.13   Litigation...................................   20
              4.14   Fees.........................................   20
              4.15   Accounting Matters...........................   20
              4.16   Employee Benefit Plans.......................   21
              4.17   Contracts....................................   24
              4.18   Accounts Receivable and Inventories..........   25
              4.19   Officers and Employees.......................   26
              4.20   Labor Relations..............................   27
              4.21   Undisclosed Liabilities......................   27
              4.22   Customer and Supplier Relationships..........   27
              4.23   No Recalls...................................   27
              4.24   Operation of MSI's Business..................   28
              4.25   Permits; Compliance..........................   28
              4.26   Product Warranties and Liabilities...........   29
              4.27   Environmental Matters........................   29
              4.28   OSHA Matters.................................   30
              4.29   Insurance....................................   30
              4.30   Opinion of Financial Advisor.................   31
              4.31   Board Recommendation.........................   31
              4.32   DGCL Section 203 and Missouri Takeover
                       Laws.......................................   31
              4.33   Franchise Agreements.........................   31
              4.34   Employment Agreement.........................   32
              4.35   Investment Company...........................   33

         ARTICLE V:  COVENANTS OF THE PARTIES.....................   33
              5.1    Mutual Covenants.............................   33
                     (a)  General.................................   33
                     (b)  HSR Act.................................   33
                     (c)  Other Governmental Matters..............   33
                     (d)  Pooling-of-Interests and Tax-Free
                            Treatment.............................   34
                     (e)  Public Announcements....................   34
                     (f)  Access..................................   34
              5.2    Covenants of Cardinal........................   34
                     (a)  Preparation of Cardinal Registration
                            Statement.............................   34
                     (b)  Conduct of Cardinal's Operations........   35
                     (c)  Directors' and Officers' Insurance......   35
                     (d)  Indemnification.........................   35


                                       -ii-<PAGE>





                                                                    PAGE

                     (e)  Employee Benefits.......................   35
                     (f)  Headquarters and Name...................   35

              5.3    Covenants of MSI.............................   36
                     (a)  MSI Shareholders Meeting................   36
                     (b)  Information for the Registration 
                            Statement and Preparation of
                            MSI Proxy Statement...................   36
                     (c)  Conduct of MSI's Operations.............   36
                     (d)  No Solicitation.........................   39
                     (e)  Affiliates of MSI.......................   41
                     (f)  Notification of Certain Matters.........   41

         ARTICLE VI:  CONDITIONS..................................   41
              6.1    Mutual Conditions............................   41
              6.2    Conditions to Obligations of MSI.............   42
              6.3    Conditions to Obligations of Cardinal and
                       Subcorp....................................   43

         ARTICLE VII:  TERMINATION AND AMENDMENT..................   44
              7.1    Termination..................................   44
              7.2    Effect of Termination........................   46
              7.3    Amendment....................................   46
              7.4    Extension; Waiver............................   47

         ARTICLE VIII:  MISCELLANEOUS.............................   47
              8.1    Survival of Representations and
                       Warranties.................................   47
              8.2    Notices......................................   47
              8.3    Interpretation...............................   48
              8.4    Counterparts.................................   48
              8.5    Entire Agreement.............................   49
              8.6    Third Party Beneficiaries....................   49
              8.7    Governing Law................................   49
              8.8    Specific Performance.........................   49
              8.9    Assignment...................................   49
              8.10   Expenses.....................................   49


         
                                      -iii-<PAGE>







                           AGREEMENT AND PLAN OF MERGER


                   This Agreement and Plan of Merger (this "Agreement")
         is made and entered into as of the 26th day of August, 1995, by
         and among Cardinal Health, Inc., an Ohio corporation ("Car-
         dinal"), Arch Merger Corp., a Delaware corporation and a wholly
         owned direct subsidiary of Cardinal ("Subcorp"), and Medicine
         Shoppe International, Inc., a Delaware corporation ("MSI").


                              PRELIMINARY STATEMENTS

                   A.  Cardinal desires to acquire the pharmacy fran-
         chise business and other businesses operated by MSI through the
         merger (the "Merger") of Subcorp with and into MSI, with MSI as
         the surviving corporation, pursuant to which each share of MSI
         Common Stock (as defined in Section 4.4) outstanding at the
         Effective Time (as defined in Section 1.2) will be converted
         into the right to receive Cardinal Common Shares (as defined in
         Section 3.3) as more fully provided herein.

                   B.  MSI desires to combine its pharmacy franchise and
         other businesses with the wholesale drug distribution and re-
         lated businesses operated by Cardinal and for the holders of
         shares of MSI Common Stock ("MSI Shareholders") to have a con-
         tinuing equity interest in the combined Cardinal/MSI busi-
         nesses.

                   C.  The parties intend that the Merger constitute a
         tax-free "reorganization" within the meaning of Section
         368(a)(1)(A) of the Internal Revenue Code of 1986, as amended
         (the "Code"), by reason of Section 368(a)(2)(E) thereof.

                   D.  The parties intend that the Merger be accounted
         for as a pooling-of-interests for financial reporting purposes.

                   E.  The respective Boards of Directors of Cardinal,
         Subcorp and MSI have determined the Merger in the manner con-
         templated herein to be desirable and in the best interests of
         their respective shareholders and, by resolutions duly adopted,
         have approved and adopted this Agreement.


                                    AGREEMENT

                   Now, therefore, in consideration of these premises
         and the mutual and dependent promises hereinafter set forth,
         the parties hereto agree as follows:<PAGE>







                                    ARTICLE I

                                    THE MERGER

                   1.1  The Merger.  Upon the terms and subject to the
         conditions hereof, and in accordance with the provisions of the
         Delaware General Corporation Law (the "DGCL"), Subcorp shall be
         merged with and into MSI as soon as practicable following the
         satisfaction or waiver of the conditions set forth in Article
         VI.  Following the Merger, the separate corporate existence of
         Subcorp shall cease and MSI shall continue its existence under
         the laws of the State of Delaware.  MSI, in its capacity as the
         corporation surviving the Merger, is hereinafter sometimes re-
         ferred to as the "Surviving Corporation."

                   1.2  Effective Time.  The Merger shall be consummated
         by filing with the Secretary of State of the State of Delaware
         (the "Delaware Secretary of State") a certificate of merger
         (the "Certificate of Merger") in such form as is required by
         and executed in accordance with Section 251(c) of the DGCL.
         The Merger shall become effective (the "Effective Time") when
         the Certificate of Merger has been filed with the Delaware Sec-
         retary of State or at such later time as shall be specified in
         the Certificate of Merger.  Prior to the filing referred to in
         this Section 1.2, a closing (the "Closing") shall be held at
         the offices of Cardinal, 655 Metro Place South, Suite 925, Dub-
         lin, Ohio 43017, or such other place as the parties may agree
         on the date (the "Closing Date") set by Cardinal, which date
         shall be within ten business days following the later of (x)
         the date of the meeting of MSI Shareholders at which the vote
         to approve the Merger is obtained and (y) the date upon which
         all conditions set forth in Article VI hereof have been satis-
         fied or waived.

                   1.3  Effects of the Merger.  The Merger shall have
         the effects set forth in Section 259 of the DGCL.

                   1.4  Certificate of Incorporation and Bylaws.  The
         Certificate of Merger shall provide that at the Effective Time
         (i) the Certificate of Incorporation of MSI as in effect im-
         mediately prior to the Effective Time shall be the Certificate
         of Incorporation of the Surviving Corporation, amended as of
         the Effective Time so as to contain the provisions, and only
         the provisions, contained immediately prior thereto in the Cer-
         tificate of Incorporation of Subcorp, except for Article I
         thereof, which shall continue to read "The name of the corpo-
         ration (hereinafter called the `Corporation') is `Medicine
         Shoppe International, Inc.'", and (ii) the Bylaws of MSI in
         effect immediately prior to the Effective Time shall be the 



                                       -2-<PAGE>







         Bylaws of the Surviving Corporation, amended as of the Effec-
         tive Time so as to contain the provisions, and only the provi-
         sions, contained in the Bylaws of Subcorp immediately prior
         thereto; in each case until amended in accordance with ap-
         plicable law.

                   1.5  Directors and Officers.  From and after the Ef-
         fective Time, the officers of MSI shall be the officers of the
         Surviving Corporation and the directors of Subcorp shall be the
         directors of the Surviving Corporation, in each case until
         their respective successors are duly elected and qualified.

                   1.6  Additional Actions.  If, at any time after the
         Effective Time, the Surviving Corporation shall consider or be
         advised that any further deeds, assignments or assurances in
         law or any other acts are necessary or desirable to (a) vest,
         perfect or confirm, of record or otherwise, in the Surviving
         Corporation its right, title or interest in, to or under any of
         the rights, properties or assets of MSI, or (b) otherwise carry
         out the provisions of this Agreement, MSI and its officers and
         directors shall be deemed to have granted to the Surviving Cor-
         poration an irrevocable power of attorney to execute and de-
         liver all such deeds, assignments or assurances in law and to
         take all acts necessary, proper or desirable to vest, perfect
         or confirm title to and possession of such rights, properties
         or assets in the Surviving Corporation and otherwise to carry
         out the provisions of this Agreement, and the officers and di-
         rectors of the Surviving Corporation are authorized in the name
         of MSI or otherwise to take any and all such action.


                                    ARTICLE II

                             CONVERSION OF SECURITIES

                   2.1  Conversion of Capital Stock.  At the Effective
         Time, by virtue of the Merger and without any action on the
         part of Cardinal, Subcorp or MSI:

                   (a)  Each share of common stock, $0.01 par value, of
              Subcorp issued and outstanding immediately prior to the
              Effective Time shall be converted into one share of common
              stock, $0.01 par value, of the Surviving Corporation.
              Such newly issued shares shall thereafter constitute all
              of the issued and outstanding capital stock of the Surviv-
              ing Corporation.

                   (b)  Each share of MSI Common Stock issued and out-
              standing immediately prior to the Effective Time shall be
              converted into and represent a number of Cardinal Common 


                                       -3-<PAGE>







              Shares (rounded to the nearest ten-thousandth of a share)
              (the "Exchange Ratio") in an amount equal to the quotient
              obtained by dividing (x) $45.00 (the "Base Share Price")
              by (y) the average of the closing prices of Cardinal Com-
              mon Shares as reported on the New York Stock Exchange
              ("NYSE") Composite Tape ("NYSE Composite Tape") on each of
              the last fifteen trading days ending on the second trading
              day prior to the Closing Date (the "Average Share Price");
              provided, however, that (i) if the Average Share Price is
              less than $51.58 and equal to or greater than $49.29, then
              the Exchange Ratio shall be equal to 0.8724, (ii) if (x)
              the Average Share Price is less than $49.29 and equal to
              or greater than $46.27 and (y) Cardinal has made an Ad-
              justment Election (as defined in Section 7.1(d)), then the
              Base Share Price shall be equal to $43.00, (iii) if (x)
              the Average Share Price is less than $49.29 and (y) Cardi-
              nal has not made an Adjustment Election, then the Exchange
              Ratio shall be equal to 0.8724, (iv) if (x) the Average
              Share Price is less than $46.27 and (y) Cardinal has made
              an Adjustment Election, then the Exchange Ratio shall be
              equal to 0.9293, and (v) if the Average Share Price is
              greater than $58.17, then the Exchange Ratio shall be
              equal to 0.7736.  No certificates for fractional Cardinal
              Common Shares shall be issued as a result of the conver-
              sion provided for in this Section 2.1(b).  To the extent
              that an outstanding share of MSI Common Stock would oth-
              erwise have become a fractional Cardinal Common Share, the
              holder thereof, upon presentation of such fractional in-
              terest represented by an appropriate certificate for MSI
              Common Stock to the Exchange Agent pursuant to Section
              2.2, shall be entitled to receive a cash payment therefor
              in an amount equal to the value (determined with reference
              to the closing price of Cardinal Common Shares on the NYSE
              Composite Tape on the last full trading day immediately
              prior to the Effective Time) of such fractional interest.
              Such payment with respect to fractional shares is merely
              intended to provide a mechanical rounding off of, and is
              not a separately bargained for, consideration.  If more
              than one certificate representing shares of MSI Common
              Stock shall be surrendered for the account of the same
              holder, the number of Cardinal Common Shares for which
              certificates have been surrendered shall be computed on
              the basis of the aggregate number of shares represented by
              the certificates so surrendered.

                   (c)  Each share of capital stock of MSI held in the
              treasury of MSI shall be cancelled and retired and no pay-
              ment shall be made in respect thereof.





                                       -4-<PAGE>







                   (d)  In the event that prior to the Effective Time
              Cardinal shall declare a stock dividend or other distribu-
              tion payable in Cardinal Common Shares or securities con-
              vertible into Cardinal Common Shares, or effect a stock
              split, reclassification, combination or other change with
              respect to Cardinal Common Shares, the Average Share Price
              and Exchange Ratio values set forth in clauses (i), (ii),
              (iii), (iv) and (v) of Section 2.1(b) shall be adjusted to
              reflect such dividend, distribution, stock split, reclas-
              sification, combination or other change.

                   2.2  Exchange of Certificates.

                   (a)  Exchange Agent.  Promptly following the Effec-
         tive Time, Cardinal shall deposit with Bank One, Indianapolis,
         NA or such other exchange agent as may be designated by Cardi-
         nal (the "Exchange Agent"), for the benefit of MSI Sharehold-
         ers, for exchange in accordance with this Section 2.2, certifi-
         cates representing Cardinal Common Shares issuable pursuant to
         Section 2.1 in exchange for outstanding shares of MSI Common
         Stock and shall from time-to-time deposit cash in an amount
         reasonably expected to be paid pursuant to Section 2.1(b) (such
         Cardinal Common Shares and cash, together with any dividends or
         distributions with respect thereto, being hereinafter referred
         to as the "Exchange Fund").

                   (b)  Exchange Procedures.  As soon as practicable
         after the Effective Time, the Exchange Agent shall mail to each
         holder of record of a certificate or certificates (the "Cer-
         tificates") which immediately prior to the Effective Time rep-
         resented outstanding shares of MSI Common Stock whose shares
         were converted into the right to receive Cardinal Common Shares
         pursuant to Section 2.1(b) (i) a letter of transmittal (which
         shall specify that delivery shall be effected, and risk of loss
         and title to the Certificates shall pass, only upon delivery of
         the Certificates to the Exchange Agent and shall be in such
         form and have such other provisions as Cardinal may reasonably
         specify) and (ii) instructions for effecting the surrender of
         the Certificates in exchange for certificates representing Car-
         dinal Common Shares.  Upon surrender of a Certificate for can-
         cellation to the Exchange Agent, together with a duly executed
         letter of transmittal, the holder of such Certificate shall be
         entitled to receive in exchange therefor (x) a certificate rep-
         resenting that number of Cardinal Common Shares which such
         holder has the right to receive pursuant to Section 2.1 and (y)
         a check representing the amount of cash in lieu of fractional
         shares, if any, and unpaid dividends and distributions, if any,
         which such holder has the right to receive pursuant to the pro-
         visions of this Article II, after giving effect to any required
         withholding tax, and the shares represented by the Certificate 



                                       -5-<PAGE>







         so surrendered shall forthwith be cancelled.  No interest will
         be paid or accrued on the cash in lieu of fractional shares and
         unpaid dividends and distributions, if any, payable to holders
         of shares of MSI Common Stock.  In the event of a transfer of
         ownership of shares of MSI Common Stock which is not registered
         on the transfer records of MSI, a certificate representing the
         proper number of Cardinal Common Shares, together with a check
         for the cash to be paid in lieu of fractional shares, if any,
         and unpaid dividends and distributions, if any, may be issued
         to such transferee if the Certificate representing such shares
         of MSI Common Stock held by such transferee is presented to the
         Exchange Agent, accompanied by all documents required to evi-
         dence and effect such transfer and to evidence that any appli-
         cable stock transfer taxes have been paid.  Until surrendered
         as contemplated by this Section 2.2, each Certificate shall be
         deemed at any time after the Effective Time to represent only
         the right to receive upon surrender a certificate representing
         Cardinal Common Shares and cash in lieu of fractional shares,
         if any, and unpaid dividends and distributions, if any, as pro-
         vided in this Article II.

                   (c)  Distributions with Respect to Unexchanged
         Shares.  Notwithstanding any other provisions of this Agree-
         ment, no dividends or other distributions declared or made af-
         ter the Effective Time with respect to Cardinal Common Shares
         having a record date after the Effective Time shall be paid to
         the holder of any unsurrendered Certificate, and no cash pay-
         ment in lieu of fractional shares shall be paid to any such
         holder, until the holder shall surrender such Certificate as
         provided in this Section 2.2.  Subject to the effect of Appli-
         cable Laws (as defined in Section 3.9), following surrender of
         any such Certificate, there shall be paid to the holder of the
         certificates representing whole Cardinal Common Shares issued
         in exchange therefor, without interest, (i) at the time of such
         surrender, the amount of dividends or other distributions with
         a record date after the Effective Time theretofore payable with
         respect to such whole Cardinal Common Shares and not paid, less
         the amount of any withholding taxes which may be required
         thereon, and (ii) at the appropriate payment date subsequent to
         surrender, the amount of dividends or other distributions with
         a record date after the Effective Time but prior to surrender
         and a payment date subsequent to surrender payable with respect
         to such whole Cardinal Common Shares, less the amount of any
         withholding taxes which may be required thereon.

                   (d)  No Further Ownership Rights in MSI Common Stock.
         All Cardinal Common Shares issued upon surrender of Certifi-
         cates in accordance with the terms hereof (including any cash
         paid pursuant to this Article II) shall be deemed to have been
         issued in full satisfaction of all rights pertaining to such 



                                       -6-<PAGE>







         shares of MSI Common Stock represented thereby, and there shall
         be no further registration of transfers on the stock transfer
         books of MSI of shares of MSI Common Stock outstanding immedi-
         ately prior to the Effective Time.  If, after the Effective
         Time, Certificates are presented to the Surviving Corporation
         for any reason, they shall be cancelled and exchanged as pro-
         vided in this Section 2.2.  Certificates surrendered for ex-
         change by any person constituting an "affiliate" of MSI for
         purposes of Rule 145(c) under the Securities Act of 1933, as
         amended (the "Securities Act"), shall not be exchanged until
         Cardinal has received written undertakings from such person in
         the form attached hereto as Exhibit A.

                   (e)  Termination of Exchange Fund.  Any portion of
         the Exchange Fund which remains undistributed to MSI Sharehold-
         ers for six months after the Effective Time shall be delivered
         to Cardinal, upon demand thereby, and holders of shares of MSI
         Common Stock who have not theretofore complied with this Sec-
         tion 2.2 shall thereafter look only to Cardinal for payment of
         any claim to Cardinal Common Shares, cash in lieu of fractional
         shares thereof, or dividends or distributions, if any, in re-
         spect thereof.

                   (f)  No Liability.  None of Cardinal, the Surviving
         Corporation or the Exchange Agent shall be liable to any person
         in respect of any shares of MSI Common Stock (or dividends or
         distributions with respect thereto) or cash from the Exchange
         Fund delivered to a public official pursuant to any applicable
         abandoned property, escheat or similar law.  If any Certifi-
         cates shall not have been surrendered prior to seven years af-
         ter the Effective Time of the Merger (or immediately prior to
         such earlier date on which any cash, any cash in lieu of frac-
         tional shares or any dividends or distributions with respect to
         whole shares of Cardinal Common Shares in respect of such Cer-
         tificate would otherwise escheat to or become the property of
         any Governmental Authority (as defined in Section 3.4)), any
         such cash, dividends or distributions in respect of such Cer-
         tificate shall, to the extent permitted by Applicable Law (as
         defined in Section 3.9), become the property of Cardinal, free
         and clear of all claims or interest of any person previously
         entitled thereto.

                   (g)  Investment of Exchange Fund.  The Exchange Agent
         shall invest any cash included in the Exchange Fund, as di-
         rected by Cardinal, on a daily basis.  Any interest and other
         income resulting from such investments shall be paid to Cardi-
         nal upon termination of the Exchange Fund pursuant to Section
         2.2(e).  





                                       -7-<PAGE>







                   2.3  Treatment of Stock Options and Restricted Stock.

                   (a)  Prior to the Effective Time, Cardinal and MSI
         shall take all such actions as may be necessary to cause (i)
         each unexpired and unexercised option under stock option plans
         of MSI in effect on the date hereof which has been granted to
         directors or current or former officers or employees of MSI by
         MSI (each, an "MSI Option") to be automatically converted at
         the Effective Time into an option (a "Cardinal Exchange
         Option") to purchase that number of Cardinal Common Shares
         equal to the number of shares of MSI Common Stock issuable
         immediately prior to the Effective Time upon exercise of the
         MSI Option (without regard to actual restrictions on
         exercisability) multiplied by the Exchange Ratio, with an
         exercise price equal to the exercise price which existed under
         the corresponding MSI Option divided by the Exchange Ratio, and
         with other terms and conditions, including the grant date for
         vesting purposes, that are the same as the terms and conditions
         of such MSI Option immediately before the Effective Time,
         provided that with respect to any MSI Option that is an
         "incentive stock option" within the meaning of the Code, the
         foregoing conversion shall be carried out in a manner
         satisfying the requirements of Section 424(a) of the Code; and
         (ii) each outstanding award of unvested shares of restricted
         stock which has been granted to current or former officers or
         employees of MSI by MSI (each such share, a share of "MSI
         Restricted Stock") to be automatically converted at the
         Effective Time into a number of shares of restricted stock of
         Cardinal ("Cardinal Exchange Restricted Stock") equal to the
         number of such shares of MSI Restricted Stock comprising the
         award, multiplied by the Exchange Ratio, with the same terms
         and conditions as were applicable to such MSI Restricted Stock
         award immediately before the Effective Time.  In connection
         with the issuance of Cardinal Exchange Options, Cardinal shall
         (i) reserve for issuance the number of Cardinal Common Shares
         that will become subject to Cardinal Exchange Options pursuant
         to this Section 2.3 and (ii) from and after the Effective Time,
         upon exercise of Cardinal Exchange Options, make available for
         issuance all Cardinal Common Shares covered thereby, subject to
         the terms and conditions applicable thereto.

                   (b)  MSI agrees to issue treasury shares of MSI, to
         the extent available, upon the exercise of MSI Options prior to
         the Effective Time.

                   (c)  Cardinal agrees to file with the Securities and
         Exchange Commission (the "Commission") within one month after
         the Closing Date a registration statement on Form S-8 or other
         appropriate form under the Securities Act to register Cardinal
         Common Shares issuable upon exercise of the Cardinal Exchange 



                                       -8-<PAGE>







         Options and use its reasonable efforts to cause such registra-
         tion statement to remain effective until the exercise or expi-
         ration of such options.


                                   ARTICLE III

              REPRESENTATIONS AND WARRANTIES OF CARDINAL AND SUBCORP

                   In order to induce MSI to enter into this Agreement,
         and in order to induce each of the MSI Shareholders entering
         into a Support Agreement (as defined in Section 4.32) to enter
         into such Support Agreement, Cardinal and Subcorp hereby repre-
         sent and warrant to MSI that the statements contained in this
         Article III are true, correct and complete.  

                   3.1  Organization and Standing.  Each of Cardinal and
         Subcorp is a corporation duly organized, validly existing and
         in good standing under the laws of its state of incorporation
         with full power and authority (corporate and other) to own,
         lease, use and operate its properties and to conduct its busi-
         ness as and where now owned, leased, used, operated and con-
         ducted.  Each of Cardinal and Subcorp is duly qualified to do
         business and in good standing in each jurisdiction in which the
         nature of the business conducted by it or the property it owns,
         leases or operates, makes such qualification necessary, except
         where the failure to be so qualified or in good standing in
         such jurisdiction would not have a material adverse effect on
         Cardinal.  Neither Cardinal nor Subcorp is in default in the
         performance, observance or fulfillment of any provision of its
         Articles of Incorporation, as amended and restated (the "Cardi-
         nal Articles"), or Code of Regulations or Certificate of Incor-
         poration or Bylaws, respectively.

                   3.2  Corporate Power and Authority.  Each of Cardinal
         and Subcorp has all requisite corporate power and authority to
         enter into this Agreement and to consummate the transactions
         contemplated by this Agreement.  The execution and delivery of
         this Agreement and the consummation of the transactions contem-
         plated hereby have been duly authorized by all necessary corpo-
         rate action on the part of each of Cardinal and Subcorp.  This
         Agreement has been duly executed and delivered by each of Car-
         dinal and Subcorp, and constitutes the legal, valid and binding
         obligation of each of Subcorp and Cardinal enforceable against
         each of them in accordance with its terms.

                   3.3  Capitalization of Cardinal.  As of July 31,
         1995, Cardinal's authorized capital stock consisted solely of
         (a) 60,000,000 common shares, without par value ("Cardinal Com-
         mon Shares"), of which (i) 41,962,973 shares were issued and 



                                       -9-<PAGE>







         outstanding, (ii) 193,292 shares were issued and held in trea-
         sury (which does not include the shares reserved for issuance
         as set forth in clause (a)(iii) below), and (iii) 1,930,979.38
         shares were reserved for issuance upon the exercise or conver-
         sion of options, warrants or convertible securities granted or
         issuable by Cardinal, (b) 5,000,000 Class B common shares,
         without par value ("Cardinal Class B Common Shares"), of which
         (i) none was issued and outstanding, (ii) none were issued and
         held in treasury (which does not include the shares reserved
         for issuance set forth in clause (b)(iii) below) and (iii) none
         was reserved for issuance upon exercise or conversion of op-
         tions, warrants or convertible securities granted or issuable
         by Cardinal, and (c) 500,000 Non-Voting Preferred Shares, with-
         out par value, none of which was issued and outstanding or re-
         served for issuance.  Each outstanding share of Cardinal capi-
         tal stock is, and all Cardinal Common Shares to be issued in
         connection with the Merger will be, duly authorized and validly
         issued, fully paid and nonassessable, and each outstanding
         share of Cardinal capital stock has not been, and all Cardinal
         Common Shares to be issued in connection with the Merger will
         not be, issued in violation of any preemptive or similar
         rights.  Other than as set forth in the first sentence hereof
         or in Section 3.3 to the disclosure schedule (the "Cardinal
         Disclosure Schedule") delivered by Cardinal to MSI and dated
         the date hereof, there are no outstanding subscriptions, op-
         tions, warrants, puts, calls, agreements, understandings,
         claims or other commitments or rights of any type relating to
         the issuance, sale or transfer by Cardinal of any securities of
         Cardinal, nor are there outstanding any securities which are
         convertible into or exchangeable for any shares of capital
         stock of Cardinal.

                   3.4  Conflicts, Consents and Approval.  Neither the
         execution and delivery of this Agreement by Cardinal or Subcorp
         nor the consummation of the transactions contemplated hereby
         will:

                   (a)  conflict with, or result in a breach of any pro-
              vision of the Cardinal Articles or Code of Regulations of
              Cardinal or the Certificate of Incorporation or Bylaws of
              Subcorp;

                   (b)  violate, or conflict with, or result in a breach
              of any provision of, or constitute a default (or an event
              which, with the giving of notice, the passage of time or
              otherwise, would constitute a default) under, or entitle
              any party (with the giving of notice, the passage of time
              or otherwise) to terminate, accelerate or call a default
              under, or result in the creation of any lien, security
              interest, charge or encumbrance upon any of the properties 



                                       -10-<PAGE>







              or assets of Cardinal or any of its subsidiaries under,
              any of the terms, conditions or provisions of any note,
              bond, mortgage, indenture, deed of trust, license, con-
              tract, undertaking, agreement, lease or other instrument
              or obligation to which Cardinal or any of its subsidiaries
              is a party;

                   (c)  violate any order, writ, injunction, decree,
              statute, rule or regulation, applicable to Cardinal or any
              of its subsidiaries or their respective properties or as-
              sets; or

                   (d)  require any action or consent or approval of, or
              review by, or registration or filing by Cardinal or any of
              its affiliates with any third party or any court, arbitral
              tribunal, administrative agency or commission or other
              governmental or regulatory body, agency, instrumentality
              or authority (a "Governmental Authority"), other than (i)
              actions required by the Hart-Scott-Rodino Antitrust Im-
              provements Act of 1976, as amended, and the rules and
              regulations promulgated thereunder (the "HSR Act"), and
              (ii) registrations or other actions required under federal
              and state securities laws as are contemplated by this
              Agreement; 

         except in the case of (b), (c) and (d) for any of the foregoing
         that would not have a material adverse effect on Cardinal.

                   3.5  Brokerage and Finder's Fees.  Except for
         Cardinal's obligation to Smith Barney Inc. ("Smith Barney"),
         neither Cardinal nor any shareholder, director, officer or em-
         ployee thereof, has incurred or will incur on behalf of Cardi-
         nal, any brokerage, finder's or similar fee in connection with
         the transactions contemplated by this Agreement.

                   3.6  Accounting Matters.  To the best knowledge of
         Cardinal, neither Cardinal nor any of its affiliates has taken
         or agreed to take any action that (without giving effect to any
         actions taken or agreed to be taken by MSI or any of its af-
         filiates) would prevent Cardinal from accounting for the busi-
         ness combination to be effected by the Merger as a pooling-of-
         interests for financial reporting purposes.

                   3.7  Cardinal SEC Documents.  Cardinal has timely
         filed with the Commission and has heretofore made available to
         MSI true, correct and complete copies of all forms, reports,
         schedules, statements and other documents required to be filed
         by it since June 30, 1992 under the Securities Exchange Act of
         1934, as amended (together with the rules and regulations
         thereunder, the "Exchange Act") or the Securities Act (such 



                                       -11-<PAGE>







         documents, as amended since the time of filing, collectively,
         the "Cardinal SEC Documents").  The Cardinal SEC Documents,
         including, without limitation, any financial statements or
         schedules included therein, at the time filed (and, in the case
         of registration statements and proxy statements, on the dates
         of effectiveness and the dates of mailing, respectively) (a)
         did not contain any untrue statement of a material fact or omit
         to state a material fact required to be stated therein or nec-
         essary in order to make the statements therein, in light of the
         circumstances under which they were made, not misleading, and
         (b) complied in all material respects with the applicable re-
         quirements of the Exchange Act and the Securities Act, as the
         case may be.  The financial statements of Cardinal included in
         the Cardinal SEC Documents at the time filed (and, in the case
         of registration statements and proxy statements, on the date of
         effectiveness and the date of mailing, respectively) complied
         as to form in all material respects with applicable accounting
         requirements and with the published rules and regulations of
         the Commission with respect thereto, were prepared in ac-
         cordance with generally accepted accounting principles applied
         on a consistent basis during the periods involved (except as
         may be indicated in the notes thereto or, in the case of unau-
         dited statements, as permitted by Form 10-Q of the Commission),
         and fairly present (subject in the case of unaudited statements
         to normal, recurring audit adjustments) the consolidated finan-
         cial position of Cardinal and its consolidated subsidiaries as
         at the dates thereof and the consolidated results of their op-
         erations and cash flows for the periods then ended.

                   3.8  Registration Statement.  None of the information
         relating to Cardinal to be included in the registration state-
         ment on Form S-4 to be filed with the Commission by Cardinal
         under the Securities Act, including the prospectus (as amended,
         supplemented or modified, the "Prospectus") relating to Cardi-
         nal Common Shares to be issued in the Merger and the proxy
         statement and form of proxy relating to the vote of MSI Share-
         holders with respect to the Merger (collectively and as
         amended, supplemented or modified, the "Proxy Statement") con-
         tained therein (such registration statement as amended, supple-
         mented or modified, the "Registration Statement"), at the time
         the Registration Statement becomes effective or, in the case of
         the Proxy Statement, at the date of mailing, will contain any
         untrue statement of a material fact or omit to state any mate-
         rial fact required to be stated therein or necessary in order
         to make the statements therein, in light of the circumstances
         under which they are made, not misleading.  The Registration
         Statement, except for such portions thereof that relate only to
         MSI, will comply in all material respects with the provisions
         of the Securities Act.




                                       -12-<PAGE>







                   3.9  Compliance with Law.  Cardinal is in compliance
         with all applicable laws, statutes, orders, rules, regulations,
         policies or guidelines promulgated, or judgments, decisions or
         orders entered by any Governmental Authority (collectively,
         "Applicable Laws") relating to Cardinal or its business or
         properties, except where the failure to be in compliance there-
         with could not reasonably be expected to have a material ad-
         verse effect on Cardinal.

                   3.10  Litigation.  Except as set forth in Section
         3.10 to the Cardinal Disclosure Schedule or as disclosed in the
         Cardinal SEC Documents, there is no suit, claim, action, pro-
         ceeding or investigation (an "Action") pending or, to the
         knowledge of Cardinal, threatened against Cardinal which, indi-
         vidually or in the aggregate, in so far as could be reasonably
         foreseen, could reasonably be expected to have a material ad-
         verse effect on Cardinal or a material adverse effect on the
         ability of Cardinal to consummate the transactions contemplated
         hereby.  Cardinal is not subject to any outstanding order,
         writ, injunction or decree which, individually or in the ag-
         gregate insofar as can be reasonably foreseen, could have a
         material adverse effect on Cardinal or a material adverse ef-
         fect on the ability of Cardinal to consummate the transactions
         contemplated hereby.

                   3.11  State Takeover Laws.  Without regard to this
         Agreement or to the Stock Option Agreement (as defined in Sec-
         tion 4.32) or the Support Agreements (as defined in Section
         4.32) or any other written agreement or understanding between
         Cardinal (or a subsidiary of Cardinal) and MSI, Cardinal was
         not at any time during the three years preceding the date of
         this Agreement an "interested stockholder" (as such term is
         defined in Section 203(c) of the DGCL) of MSI.

                   3.12  No Material Adverse Change.  From March 31,
         1995 through the date of this Agreement, there has been no ma-
         terial adverse change in the assets, liabilities, results of
         operations, prospects, business or financial condition of Car-
         dinal and its subsidiaries, taken as a whole, or any event,
         occurrence or development which may reasonably be expected to
         result in such a change or to have a material adverse effect on
         the ability of Cardinal or Subcorp to consummate the transac-
         tions contemplated hereby.










                                       -13-<PAGE>







                                    ARTICLE IV

                      REPRESENTATIONS AND WARRANTIES OF MSI

                   In order to induce Subcorp and Cardinal to enter into
         this Agreement, MSI hereby represents and warrants to Cardinal
         and Subcorp that the statements contained in this Article IV
         are true, correct and complete.  

                   4.1  Organization and Standing.  MSI is a corporation
         duly organized, validly existing and in good standing under the
         laws of the State of Delaware with full power and authority
         (corporate and other) to own, lease, use and operate its prop-
         erties and to conduct its business as and where now owned,
         leased, used, operated and conducted.  MSI is duly qualified to
         do business and in good standing in each jurisdiction listed in
         Section 4.1 to the disclosure schedule (the "MSI Disclosure
         Schedule") delivered by MSI to Cardinal and dated the date
         hereof, is not qualified to do business in any other jurisdic-
         tion and neither the nature of the business conducted by it nor
         the property it owns, leases or operates requires it to qualify
         to do business as a foreign corporation in any other jurisdic-
         tion, except where the failure to be so qualified or in good
         standing in such jurisdiction would not have a material adverse
         effect on MSI.  MSI is not in default in the performance, ob-
         servance or fulfillment of any provision of its Certificate of
         Incorporation, as amended, or Bylaws.

                   4.2  Subsidiaries.  MSI does not own, directly or
         indirectly, any equity or other ownership interest in any cor-
         poration, partnership, joint venture or other entity or en-
         terprise, except for the subsidiaries set forth in Section 4.2
         to the MSI Disclosure Schedule.  Except as set forth in Section
         4.2 to the MSI Disclosure Schedule, MSI is not subject to any
         obligation or requirement to provide funds to or make any in-
         vestment (in the form of a loan, capital contribution or other-
         wise) in any such entity.  MSI owns directly or indirectly each
         of the outstanding shares of capital stock (or other ownership
         interests having by their terms ordinary voting power to elect
         a majority of directors or others performing similar functions
         with respect to such subsidiary) of each of MSI's subsidiaries.
         Each of the outstanding shares of capital stock of each of
         MSI's subsidiaries is duly authorized, validly issued, fully
         paid and nonassessable, and is owned, directly or indirectly,
         by MSI free and clear of all liens, pledges, security inter-
         ests, claims or other encumbrances.  The following information
         for each subsidiary of MSI is set forth in Section 4.2 to the
         MSI Disclosure Schedule, as applicable:  (i) its name and ju-
         risdiction of incorporation or organization; (ii) its autho-
         rized capital stock or share capital; and (iii) the number of 



                                       -14-<PAGE>







         issued and outstanding shares of capital stock or share capital
         and the record owner(s) thereof.  Other than as set forth in
         Section 4.2 to the MSI Disclosure Schedule, there are no out-
         standing subscriptions, options, warrants, puts, calls, agree-
         ments, understandings, claims or other commitments or rights of
         any type relating to the issuance, sale or transfer of any se-
         curities of any subsidiary of MSI, nor are there outstanding
         any securities which are convertible into or exchangeable for
         any shares of capital stock of any subsidiary of MSI; and no
         subsidiary of MSI has any obligation of any kind to issue any
         additional securities or to pay for securities of any subsid-
         iary of MSI or any predecessor thereof.

                   4.3  Corporate Power and Authority.  MSI has all req-
         uisite corporate power and authority to enter into this Agree-
         ment and, subject to authorization of the Merger and the trans-
         actions contemplated hereby by MSI Shareholders, to consummate
         the transactions contemplated by this Agreement.  The execution
         and delivery of this Agreement and the consummation of the
         transactions contemplated hereby have been duly authorized by
         all necessary corporate action on the part of MSI, subject to
         authorization of the Merger and the transactions contemplated
         hereby by MSI Shareholders.  This Agreement has been duly ex-
         ecuted and delivered by MSI and constitutes the legal, valid
         and binding obligation of MSI enforceable against it in ac-
         cordance with its terms.

                   4.4  Capitalization of MSI.  As of the close of busi-
         ness on August 24, 1995, MSI's authorized capital stock con-
         sisted solely of 10,000,000 shares of common stock, $0.01 par
         value per share ("MSI Common Stock"), of which (i) 7,721,737
         shares were issued and outstanding, (ii) none were issued and
         held in treasury (which does not include the shares reserved
         for issuance set forth in clause (iii) below) and (iii) 315,995
         shares were reserved for issuance upon the exercise or
         conversion of options, warrants or convertible securities
         granted or issued by MSI.  Each outstanding share of MSI capi-
         tal stock is duly authorized and validly issued, fully paid and
         nonassessable, and has not been issued in violation of any pre-
         emptive or similar rights.  Other than as set forth in the
         first sentence hereof or in Section 4.4 to the MSI Disclosure
         Schedule, there are no outstanding subscriptions, options, war-
         rants, puts, calls, agreements, understandings, claims or other
         commitments or rights of any type relating to the issuance,
         sale or transfer of any securities of MSI, nor are there out-
         standing any securities which are convertible into or exchange-
         able for any shares of capital stock of MSI; and MSI has no
         obligation of any kind to issue any additional securities or to
         pay for securities of MSI or any predecessor.  The issuance and
         sale by MSI of all of the shares of capital stock described in 



                                       -15-<PAGE>







         this Section 4.4 have been in compliance with federal and state
         securities laws.  The MSI Disclosure Schedule accurately sets
         forth the name of each holder of options or warrants to pur-
         chase MSI capital stock and the number of shares of MSI's capi-
         tal stock subject to such options or warrants held by each.
         Except as set forth in Section 4.4 to the MSI Disclosure Sched-
         ule, MSI has not agreed to register any securities under the
         Securities Act or under any state securities law or granted
         registration rights to any person or entity.

                   4.5  Conflicts; Consents and Approvals.  Neither the
         execution and delivery of this Agreement by MSI, nor the con-
         summation of the transactions contemplated hereby will:

                   (a)  conflict with, or result in a breach of any pro-
              vision of the Certificate of Incorporation, as amended, or
              Bylaws of MSI;

                   (b)  violate, or conflict with, or result in a breach
              of any provision of, or constitute a default (or an event
              which, with the giving of notice, the passage of time or
              otherwise, would constitute a default) under, or entitle
              any party (with the giving of notice, the passage of time
              or otherwise) to terminate, accelerate or call a default
              under, or result in the creation of any lien, security
              interest, charge or encumbrance upon any of the properties
              or assets of MSI or any of its subsidiaries under, any of
              the terms, conditions or provisions of any note, bond,
              mortgage, indenture, deed of trust, license, contract,
              undertaking, agreement, lease or other instrument or obli-
              gation to which MSI or any of its subsidiaries is a party;

                   (c)  violate any order, writ, injunction, decree,
              statute, rule or regulation applicable to MSI or any of
              its subsidiaries or any of their respective properties or
              assets; or

                   (d)  require any action or consent or approval of, or
              review by, or registration or filing by MSI or any of its
              affiliates with any third party or any Governmental Au-
              thority, other than (i) authorization of the Merger and
              the transactions contemplated hereby by MSI Shareholders,
              (ii) actions required by the HSR Act, (iii) registrations
              or other actions required under federal and state securi-
              ties laws as are contemplated by this Agreement, (iv) con-
              sents or approvals of any Governmental Authority set forth
              in Section 4.5 to the MSI Disclosure Schedule and (v)
              modifications of franchise offering materials as set forth
              in Section 4.5 to the MSI Disclosure Schedule;




                                       -16-<PAGE>







         except in the case of (b), (c) and (d) for any of the foregoing
         that would not have a material adverse effect on MSI.

                   4.6  No Material Adverse Change.  Since June 30,
         1995, MSI has conducted its business in the ordinary course,
         consistent with past practice, and there has been no material
         adverse change in the assets, liabilities, results of opera-
         tions, prospects, business or financial condition of MSI or any
         event, occurrence or development which may reasonably be ex-
         pected to result in such a change or to have a material adverse
         effect on the ability of MSI to consummate the transactions
         contemplated hereby.

                   4.7  MSI SEC Documents.  MSI has timely filed with
         the Commission and has heretofore made available to Cardinal
         true, correct and complete copies of all forms, reports, sched-
         ules, statements and other documents required to be filed by it
         since June 30, 1992 under the Exchange Act or the Securities
         Act (such documents, as amended since the time of filing, col-
         lectively, the "MSI SEC Documents").  The MSI SEC Documents,
         including, without limitation, any financial statements or
         schedules included therein, at the time filed (and, in the case
         of registration statements and proxy statements, on the dates
         of effectiveness and the dates of mailing, respectively) (a)
         did not contain any untrue statement of a material fact or omit
         to state a material fact required to be stated therein or nec-
         essary in order to make the statements therein, in light of the
         circumstances under which they were made, not misleading, and
         (b) complied in all material respects with the applicable re-
         quirements of the Exchange Act and the Securities Act, as the
         case may be.  The financial statements of MSI included in the
         MSI SEC Documents at the time filed (and, in the case of regis-
         tration statements and proxy statements, on the date of ef-
         fectiveness and the date of mailing, respectively) complied as
         to form in all material respects with applicable accounting
         requirements and with the published rules and regulations of
         the Commission with respect thereto, were prepared in accor-
         dance with generally accepted accounting principles applied on
         a consistent basis during the periods involved (except as may
         be indicated in the notes thereto or, in the case of unaudited
         statements, as permitted by Form 10-Q of the Commission), and
         fairly present (subject in the case of unaudited statements to
         normal, recurring audit adjustments) the financial position of
         MSI as at the dates thereof and the results of its operations
         and cash flows for the periods then ended.

                   4.8  Taxes.  MSI has duly filed all federal, and ma-
         terial state, local and foreign income, franchise, excise, real
         and personal property and other tax returns and reports (in-
         cluding, but not limited to, those filed on a consolidated, 



                                       -17-<PAGE>







         combined or unitary basis) required to have been filed by MSI
         prior to the date hereof.  All of the foregoing returns and
         reports are true and correct in all material respects, and MSI
         has paid or, prior to the Effective Time, will pay all taxes,
         interest and penalties required to be paid in respect of the
         periods covered by such returns or reports to any federal,
         state, foreign, local or other taxing authority.  MSI has paid
         or made adequate provision in the financial statements of MSI
         included in the MSI SEC Documents for all taxes payable in re-
         spect of all periods ending on or prior to June 30, 1995.  Nei-
         ther MSI nor any of its subsidiaries will have any material
         liability for any taxes in excess of the amounts so paid or
         reserves so established and neither MSI nor any of its subsid-
         iaries is delinquent in the payment of any material tax, as-
         sessment or governmental charge and, except as set forth in
         Section 4.8 to the MSI Disclosure Schedule, none of them has
         requested any extension of time within which to file any re-
         turns in respect of any fiscal year which have not since been
         filed.  No deficiencies for any tax, assessment or governmental
         charge have been proposed in writing, asserted or assessed
         (tentatively or definitely), in each case, by taxing authority,
         against MSI or any of its subsidiaries for which there are not
         adequate reserves.  As of the date of this Agreement, there are
         no pending requests for waivers of the time to assess any such
         tax, other than those made in the ordinary course and for which
         payment has been made or there are adequate reserves.  The fed-
         eral income tax returns of MSI and its subsidiaries have been
         audited by the Internal Revenue Service through the fiscal year
         ending September 30, 1991.  For the purposes of this Agreement,
         the term "tax" shall include all federal, state, local and for-
         eign taxes including interest and penalties thereon.  MSI has
         not filed an election under Section 341(f) of the Code to be
         treated as a consenting corporation.

                   4.9  Compliance with Law.  MSI is in compliance with,
         and at all times since June 30, 1992 has been in compliance
         with, all Applicable Laws relating to MSI or its business or
         properties, including, without limitation, laws regarding the
         provision of insurance, third party administration and primary
         health care services, the Prescription Drug Marketing Act, the
         Federal Controlled Substances Act of 1970, the Food, Drug and
         Cosmetic Act, any state Pharmacy Practice Acts, Controlled Sub-
         stance Acts, Dangerous Drugs Acts and Food, Drug and Cosmetic
         Acts and any federal, state or foreign franchise disclosure and
         relationship laws, except for any such noncompliances which,
         individually or in the aggregate, could not reasonably be ex-
         pected to have a material adverse effect on MSI.

                   4.10  Proprietary Rights.  None of the Proprietary
         Rights (as defined below) of MSI infringe upon or violate the 



                                       -18-<PAGE>







         rights of any person, firm, corporation, or other legal entity,
         except for any such immaterial infringement or violation.  For
         purposes of this Agreement, the term "Proprietary Rights" shall
         mean with respect to any person or entity:  (a) all material
         names, patents, inventions, trade secrets, proprietary rights,
         computer software, trademarks, trade names, service marks,
         logos, copyrights and franchises and all applications therefor,
         registrations thereof and licenses, sublicenses or agreements
         in respect thereof which such person or entity owns or has the
         right to use or to which such person or entity is a party; and
         (b) all filings, registrations or issuances of any of the fore-
         going with or by any Governmental Authority.  Other than the
         Proprietary Rights set forth in Section 4.10 to the MSI Disclo-
         sure Schedule, no material name, patent, invention, trade se-
         cret, proprietary right, computer software, trademark, trade
         name, service mark, logo, copyright, franchise, license, subli-
         cense, or other such right is necessary for the operation of
         the business of MSI in substantially the same manner as such
         business is presently conducted.  MSI owns all Proprietary
         Rights necessary for the operation of the business of MSI as
         currently conducted.  The business of MSI has not been and is
         not conducted in contravention of any Proprietary Right of any
         third party except such contravention which could not reason-
         ably be expected to have a material adverse effect on MSI.  Ex-
         cept as set forth in Section 4.10 to the MSI Disclosure Sched-
         ule, (i) no person or entity has a right to receive from MSI a
         royalty or similar payment in respect of any Proprietary Right,
         whether or not pursuant to any contractual arrangement entered
         into by MSI and (ii) MSI has not licensed any of its Propri-
         etary Rights other than licenses of Proprietary Rights to fran-
         chisees of MSI (or Master Franchisees) or designated vendors of
         MSI listed in Section 4.17 to the MSI Disclosure Schedule,
         which Proprietary Rights are in each case reasonably necessary
         for the franchisees to operate in the ordinary course of busi-
         ness, consistent with past practice.

                   4.11  Title to and Condition of Properties.  MSI owns
         or holds under valid leases all real property, plants, machin-
         ery and equipment necessary for the conduct of the business of
         MSI as presently conducted, except where the failure to own or
         hold such property, plants, machinery and equipment would not
         have a material adverse effect on MSI.  Section 4.11 to the MSI
         Disclosure Schedule lists, and MSI has furnished or made avail-
         able to Cardinal, copies of all third party environmental or
         other reports prepared by or for MSI with respect to the real
         property owned, leased or used by MSI.

                   4.12  Registration Statement.  None of the informa-
         tion relating to MSI to be included in the Registration State-
         ment at the time it becomes effective or, in the case of the 



                                       -19-<PAGE>







         Proxy Statement, at the date of mailing, will contain any un-
         true statement of a material fact or omit to state a material
         fact required to be stated therein or necessary in order to
         make the statements therein, in light of the circumstances un-
         der which they were made, not misleading.  The Proxy Statement,
         except for such portions thereof that relate only to Cardinal
         and its subsidiaries, will comply in all material respects with
         the provisions of the Securities Act and the Exchange Act.

                   4.13  Litigation.  There is no Action pending or, to
         the knowledge of MSI, threatened against MSI which, individu-
         ally or in the aggregate, in so far as could be reasonably
         foreseen, could reasonably be expected to have a material ad-
         verse effect on MSI or a material adverse effect on the ability
         of MSI to consummate the transactions contemplated hereby.  MSI
         is not subject to any outstanding order, writ, injunction or
         decree which, individually or in the aggregate, insofar as can
         be reasonably foreseen, could have a material adverse effect on
         MSI or a material adverse effect on the ability of MSI to con-
         summate the transactions contemplated hereby.  Except as set
         forth in Section 4.13 to the MSI Disclosure Schedule, (i) no
         Action is currently pending, nor to the knowledge of MSI, is
         any material Action threatened, and since September 30, 1992,
         no other material Action has been asserted, against MSI relat-
         ing to MSI's method of doing business or its relationship with
         past, existing or future franchisees, users, purchasers or lic-
         ensees of any Proprietary Rights, goods or services of MSI, and
         (ii) since September 30, 1992, MSI has not been subject to any
         outstanding order, writ, injunction or decree relating to MSI's
         method of doing business or its relationship with past,
         existing or future franchisees, users, purchasers or licensees
         of any Proprietary Rights, goods or services of MSI.

                   4.14  Fees.  Except for MSI's obligations to Kemper
         Securities Incorporated (a copy of the written agreement relat-
         ing to such obligations having previously been provided to Car-
         dinal), neither MSI nor any shareholder, director, officer or
         employee thereof, has incurred or will incur on behalf of MSI,
         any brokerage, finder's or similar fee in connection with the
         transactions contemplated by this Agreement.  Section 4.14 to
         the MSI Disclosure Statement discloses a bona fide estimate as
         of the date of this Agreement of the aggregate amount of all
         fees and expenses expected to be paid by MSI to all attorneys,
         accountants and investment bankers in connection with the
         Merger ("Merger Fees").  

                   4.15  Accounting Matters.  To the best knowledge of
         MSI, neither MSI nor any of its affiliates has taken or agreed
         to take any action that (without giving effect to any actions 




                                       -20-<PAGE>







         taken or agreed to be taken by Cardinal or any of its affili-
         ates) would prevent Cardinal from accounting for the business
         combination to be effected by the Merger as a pooling-of-inter-
         ests for financial reporting purposes.

                   4.16  Employee Benefit Plans.

                   (a)  For purposes of this Section 4.16, the following
         terms have the definitions given below:

                        "Controlled Group Liability" means any and all
                   liabilities under (i) Title IV of ERISA, (ii) section
                   302 of ERISA, (iii) sections 412 and 4971 of the
                   Code, (iv) the continuation coverage requirements of
                   section 601 et seq. of ERISA and section 4980B of the
                   Code, and (v) corresponding or similar provisions of
                   foreign laws or regulations.

                        "ERISA" means the Employee Retirement Income
                   Security Act of 1974, as amended, and the regulations
                   thereunder.

                        "ERISA Affiliate" means, with respect to any
                   entity, trade or business, any other entity, trade or
                   business that is a member of a group described in
                   Section 414(b), (c), (m) or (o) of the Code or Sec-
                   tion 4001(b)(1) of ERISA that includes the first en-
                   tity, trade or business, or that is a member of the
                   same "controlled group" as the first entity, trade or
                   business pursuant to Section 4001(a)(14) of ERISA.

                        "Plans" means all employee benefit plans, pro-
                   grams, policies, practices, and other arrangements
                   providing benefits to any employee or former employee
                   or beneficiary or dependent thereof, whether or not
                   written, and whether covering one person or more than
                   one person, sponsored or maintained by MSI or any of
                   its subsidiaries or to which MSI or any of its sub-
                   sidiaries contributes or is obligated to contribute.
                   Without limiting the generality of the foregoing, the
                   term "Plans" includes all employee welfare benefit
                   plans within the meaning of Section 3(1) of ERISA and
                   all employee pension benefit plans within the meaning
                   of Section 3(2) of ERISA.

                   (b)  Section 4.16 to the MSI Disclosure Schedule
         lists all Plans.  With respect to each Plan, MSI has made
         available to Cardinal a true, correct and complete copy of:
         (i) each writing constituting a part of such Plan, including
         without limitation all plan documents, benefit schedules, trust 



                                       -21-<PAGE>







         agreements, and insurance contracts and other funding vehicles;
         (ii) the most recent Annual Report (Form 5500 Series) and ac-
         companying schedule, if any; (iii) the current summary plan
         description, if any; (iv) the most recent annual financial re-
         port, if any; and (v) the most recent determination letter from
         the IRS, if any.

                   (c)  The Internal Revenue Service has issued a favor-
         able determination letter with respect to each Plan that is
         intended to be a "qualified plan" within the meaning of Section
         401(a) of the Code (a "Qualified Plan") and MSI has no knowl-
         edge of any existing circumstances or any events that have oc-
         curred that could adversely affect the qualified status of any
         Qualified Plan or the related trust.

                   (d)  All contributions required to be made to any
         Plan by Applicable Laws or by any plan document or other con-
         tractual undertaking, and all premiums due or payable with re-
         spect to insurance policies funding any Plan, for any period
         through the date hereof have been timely made or paid in full
         and through the Closing Date will be timely made or paid in
         full or, to the extent not required to be made or paid on or
         before the date hereof or the Closing Date, as applicable, have
         been or will be fully reflected if and as required in the fi-
         nancial statements and notes thereto included in the MSI SEC
         Documents filed or to be filed with the Commission.

                   (e)  MSI and its subsidiaries have complied, and are
         now in compliance, in all material respects, with all provi-
         sions of ERISA, the Code and all laws and regulations ap-
         plicable to the Plans.  To the knowledge of MSI, there is not
         now, and there are no existing circumstances that could give
         rise to, any requirement for the posting of security with re-
         spect to a Plan or the imposition of any lien on the assets of
         MSI or any of its subsidiaries under ERISA or the Code.

                   (f)  No Plan is subject to Title IV or Section 302 of
         ERISA or Section 412 or 4971 of the Code.  No Plan is a "multi-
         employer plan" within the meaning of Section 4001(a)(3) of
         ERISA (a "Multiemployer Plan") or a plan that has two or more
         contributing sponsors at least two of whom are not under common
         control, within the meaning of Section 4063 of ERISA (a "Mul-
         tiple Employer Plan"), nor has MSI or any of its subsidiaries
         or any of their respective ERISA Affiliates, at any time within
         five years before the date hereof, contributed to or been obli-
         gated to contribute to any Multiemployer Plan or Multiple Em-
         ployer Plan.

                   (g)  There does not now exist, and there are no ex-
         isting circumstances that could result in, any Controlled Group 



                                       -22-<PAGE>







         Liability that would be a liability of MSI or any of its sub-
         sidiaries following the Closing.  Without limiting the general-
         ity of the foregoing, neither MSI nor any of its subsidiaries
         nor any of their respective ERISA Affiliates has engaged in any
         transaction described in Section 4069 or Section 4204 of ERISA.

                   (h)  Except for health continuation coverage as re-
         quired by Section 4980B of the Code or Part 6 of Title I of
         ERISA, neither MSI nor any of its subsidiaries has any liabil-
         ity for life, health, medical or other welfare benefits to
         former employees or beneficiaries or dependents thereof.

                   (i)  Neither the execution and delivery of this
         Agreement nor the consummation of the transactions contemplated
         hereby will constitute a "Change in Control" for purposes of
         the Company's Executive Choice Plan, 1990 Stock Option Plan,
         Employee Stock Option Plan, or any other Plan, or otherwise
         result in, cause the accelerated vesting or delivery of, or
         increase the amount or value of, any payment or benefit to any
         employee of MSI or any of its subsidiaries.  Without limiting
         the generality of the foregoing, no amount paid or payable by
         MSI or any of its subsidiaries in connection with the transac-
         tions contemplated hereby (either solely as a result thereof or
         as a result of such transactions in conjunction with any other
         events) will be an "excess parachute payment" within the mean-
         ing of Section 280G of the Code.

                   (j)  There are no pending or threatened claims (other
         than claims for benefits in the ordinary course), lawsuits or
         arbitrations which have been asserted or instituted against the
         Employee Plans, any fiduciaries thereof with respect to their
         duties to the Employee Plans or the assets of any of the trusts
         under any of the Employee Plans which could reasonably be ex-
         pected to result in any material liability of MSI or any of its
         subsidiaries to the Pension Benefit Guaranty Corporation, the
         Department of Treasury, the Department of Labor or any multiem-
         ployer plan.

                   (k)  The terms and conditions of all awards made to
         date under the Company's Executive Choice Plan ("Awards") are
         completely and accurately described in the prospectus filed
         with the SEC in connection with that plan dated June 1, 1994,
         and such terms include the following:  restricted stock Awards
         and deferred income benefit Awards vest at the rate of 20 per-
         cent per year, beginning on June 1, 1995; stock option Awards
         become exercisable at the rate of 20 percent per year, begin-
         ning on June 1, 1995; and there are no performance goals as-
         sociated with any Awards.  Except as set forth in Section 4.16
         to the MSI Disclosure Schedule, no Awards have been made since
         the initial Awards (the "Initial Awards") were granted on June 



                                       -23-<PAGE>







         1, 1994 (subject to shareholder approval), and it was MSI's
         intention at the time the Executive Choice Plan was adopted and
         the Initial Awards granted, and has remained MSI's intention at
         all times since then, that no further Awards would be granted
         to the grantees before June 1, 1999, and MSI has taken no ac-
         tion and made no communication to any employee inconsistent
         with such intention.

                   4.17  Contracts.  Section 4.17 to the MSI Disclosure
         Schedule lists all contracts, agreements, guarantees, leases
         and executory commitments (each a "Contract") to which MSI is a
         party and which fall within any of the following categories:
         (a) material Contracts with suppliers of goods and services
         which goods and services are provided by or on behalf of MSI to
         franchisees and customers of MSI (including, without limita-
         tion, any group purchasing agreements), (b) Contracts not en-
         tered into in the ordinary course of MSI's business, (c) joint
         venture, partnership and like agreements, (d) Contracts which
         are service contracts (excluding contracts for delivery ser-
         vices entered into in the ordinary course of business) or
         equipment leases involving payments by MSI of more than
         $200,000 per year, (e) Contracts containing covenants purport-
         ing to limit the freedom of MSI to compete in any line of busi-
         ness in any geographic area or to hire any individual or group
         of individuals, (f) Contracts which after the Effective Time
         would have the effect of limiting the freedom of Cardinal or
         its subsidiaries (other than MSI and its subsidiaries) to com-
         pete in Cardinal's wholesale pharmaceutical distribution busi-
         ness (including Cardinal's PRxN program, the specialty distri-
         bution of therapeutic plasma and oncology products, its market-
         ing of pharmacy computer systems and repackaging of pharmaceu-
         tical products) in any geographic area or to hire any indi-
         vidual or group of individuals, (g) Contracts which contain
         minimum purchase conditions or requirements or other terms that
         restrict or limit the purchasing relationships of MSI or any
         franchisee thereof, (h) Contracts relating to any outstanding
         commitment for capital expenditures in excess of $200,000, (i)
         Contracts relating to the lease or sublease of or sale or pur-
         chase of real or personal property involving any annual expense
         or price in excess of $200,000 and not cancellable by MSI
         (without premium or penalty) within one month, (j) Contracts
         with any labor organization, (k) indentures, mortgages, promis-
         sory notes, loan agreements, guarantees, letters of credit or
         other agreements or instruments of MSI or commitments for bor-
         rowing, lending or guaranteeing by MSI from or to any franchi-
         see, Master Franchisee, person or entity, amounts in excess of
         $200,000 in the aggregate (and, in the case of a supplement to
         Section 4.17(k) to the MSI Disclosure Schedule to be delivered
         by MSI to Cardinal within 21 days after the date hereof, in
         excess of $150,000) or providing for the creation of any 



                                       -24-<PAGE>







         charge, security interest, encumbrance or lien upon any of the
         assets of MSI, (l) Contracts involving annual revenues or ex-
         penditures to the business of MSI in excess of .75% of MSI's
         annual revenues (other than franchise agreements), and (m) Con-
         tracts with or for the benefit of any affiliate of MSI (other
         than subsidiaries of MSI) which, when aggregated with all other
         Contracts (exclusive of normal fees paid to members of the MSI
         Board of Directors for their duties as directors) with such
         affiliate involve amounts in excess of $25,000.  All such Con-
         tracts are valid and binding obligations of MSI and, to the
         knowledge of MSI, the valid and binding obligation of each
         other party thereto except such Contracts which if not so valid
         and binding would not, individually or in the aggregate, have a
         material adverse effect on MSI.  Neither MSI nor, to the knowl-
         edge of MSI, any other party thereto is in violation of or in
         default in respect of, nor has there occurred an event or con-
         dition which with the passage of time or giving of notice (or
         both) would constitute a default under, any such Contract ex-
         cept such violations or defaults under such Contracts which,
         individually or in the aggregate, would not have a material
         adverse effect on MSI.  Within 21 days after the date of this
         Agreement, MSI may supplement or amend Sections 4.17(e),
         4.17(f) and/or 4.17(g) to the MSI Disclosure Schedule.  Cardi-
         nal shall, within five business days after the date it receives
         any such supplement or amendment, notify MSI if Cardinal has
         reasonably concluded that the inclusion in such supplement or
         amendment of any additional Contracts could reasonably be
         deemed to adversely impact in any material respect the benefits
         to be realized by Cardinal after consummation of the Merger.
         MSI may at its option (subject to Section 5.1(a)) terminate or
         amend, or take such other action with respect to, the objec-
         tionable Contracts in such supplement to the extent reasonably
         requested by Cardinal.  To the extent such objectionable
         Contracts have not been terminated, amended or otherwise dealt
         with to Cardinal's reasonable satisfaction, the representation
         in this Section 4.17 shall be deemed to be not true and correct
         in all material respects.

                   4.18  Accounts Receivable and Inventories.

                   (a)  All accounts and notes receivable (including
         finance notes receivable) and accrued interest receivable of
         MSI have arisen in the ordinary course of business and the ac-
         counts receivable reserves reflected on the balance sheet as of
         June 30, 1995 included in the MSI SEC Documents are as of such
         date established in accordance with generally accepted account-
         ing principles consistently applied and will be collectible in
         an amount, in the aggregate, not materially less than the
         amounts thereof carried on the balance sheet as of such date 




                                       -25-<PAGE>







         included in the MSI SEC Documents, net of any reserves included
         thereon, as applicable.  

                   (b)  The MSI assets which are inventories have a net
         realizable value on June 30, 1995 that is, if not equal to or
         greater than, then in all events not materially less than the
         FIFO values at which such inventories are carried on the bal-
         ance sheet of MSI as of June 30, 1995 included in the MSI SEC
         Documents.  The reserves for damaged or obsolete inventory re-
         flected on the balance sheet of MSI as of June 30, 1995 in-
         cluded in the MSI SEC Documents are, and the reserves for dam-
         aged or obsolete inventory set forth on MSI's books and records
         will be, adequate and have been or will be established in ac-
         cordance with MSI's customary practice and generally accepted
         accounting principles.  Except to the extent of any reserves
         for damaged or obsolete inventory reflected on the balance
         sheet of MSI as of June 30, 1995 included in the MSI SEC Docu-
         ments and except as set forth in Section 4.18 to the MSI Dis-
         closure Schedule:  (i) all of the inventories of MSI consist of
         a quality and quantity usable and merchantable in the ordinary
         and usual course of business, except for obsolete or damaged
         items or items of below-standard quality, substantially all of
         which have been written off or written down to fair market
         value prior to June 30, 1995, or, to the extent there are obso-
         lete or damaged items or items of below-standard quality which
         have not been so written off or written down, there is a valid
         and fully collectible claim by MSI against the manufacturer or
         supplier thereof for an amount adequate to fully compensate MSI
         therefor; (ii) all inventories not written off have been priced
         at the lower of cost or market on a FIFO basis; and (iii) sub-
         stantially all products in inventory have been purchased by MSI
         directly from the manufacturer thereof or from any authorized
         distributor of such products in accordance with Applicable Law.  

                   4.19  Officers and Employees.  Section 4.19 to the
         MSI Disclosure Schedule sets forth the names of all directors
         and officers of MSI, the total salary, bonus, fringe benefits
         and perquisites each received in the fiscal year ended Septem-
         ber 30, 1994, and any changes to the foregoing which have oc-
         curred subsequent to September 30, 1994; Section 4.19 to the
         MSI Disclosure Schedule also lists and describes the current
         compensation of all other employees of MSI.  Except as dis-
         closed in Section 4.19 to the MSI Disclosure Schedule, there
         are no other material forms of compensation paid to any such
         director, officer or employee of MSI.  Except as set forth in
         Section 4.19 to the MSI Disclosure Schedule and except for nor-
         mal fees paid to members of the MSI Board of Directors for
         their duties as directors, no officer, director, or employee of
         MSI or any other affiliate of MSI provided or caused to be pro-
         vided to MSI in its most recently completed fiscal year or is 



                                       -26-<PAGE>







         providing or causing to be provided to MSI in its current fis-
         cal year any material assets, services or facilities and MSI
         did not provide or cause to be provided in its most recently
         completed fiscal year and is not providing or causing to be
         provided in its current fiscal year to any such officer, direc-
         tor, employee or affiliate any material assets, services or
         facilities which in either case in the aggregate with respect
         to each individual involved amounts in excess of $25,000 annu-
         ally.  

                   4.20  Labor Relations.  There is no unfair labor
         practice complaint against MSI pending before the NLRB and
         there is no labor strike, dispute, slowdown or stoppage, or any
         union organizing campaign, actually pending or, to the knowl-
         edge of MSI, threatened against or involving MSI.

                   4.21  Undisclosed Liabilities.  Except (i) as and to
         the extent disclosed or reserved against on the balance sheet
         of MSI as of June 30, 1995 included in the MSI SEC Documents,
         (ii) as incurred after the date thereof in the ordinary course
         of business consistent with past practice and not prohibited by
         this Agreement or (iii) as and to the extent set forth in Sec-
         tions 4.8 and 4.13 to the MSI Disclosure Schedule, MSI does not
         have any liabilities or obligations of any nature, whether
         known or unknown, absolute, accrued, contingent or otherwise
         and whether due or to become due, that, individually or in the
         aggregate, have or could have a material adverse effect on MSI.
         The matters set forth or described in Sections 4.8 and 4.13 to
         the MSI Disclosure Schedule have not, individually or in the
         aggregate, as of the date of this Agreement, caused a material
         adverse change in the assets, liabilities, results of opera-
         tions, prospects, business or financial condition of MSI.
         Nothing in this Agreement shall be construed to require the
         conclusion that any one or more developments occurring subse-
         quent to the date of this Agreement relating directly or indi-
         rectly to any of the matters set forth or described in Sections
         4.8 and 4.13 to the MSI Disclosure Schedule does not constitute
         a change, event, occurrence or development of the type referred
         to in Section 4.6 of this Agreement.

                   4.22  Customer and Supplier Relationships.  The rela-
         tionships of MSI with its customers and suppliers are generally
         satisfactory.  

                   4.23  No Recalls.  Except as set forth in Section
         4.23 to the MSI Disclosure Schedule, no product produced for
         MSI by a third party and bearing an MSI trademark or other Pro-
         prietary Right of MSI, has been recalled voluntarily or invol-
         untarily since September 30, 1992, no such recall is being con-
         sidered by MSI, and, to the knowledge of MSI, no such recall is 



                                       -27-<PAGE>







         being considered by or has been requested or ordered by any
         Governmental Authority or consumer group.  

                   4.24  Operation of MSI's Business.  Except as set
         forth in Section 4.24 to the MSI Disclosure Schedule, since
         June 30, 1995 through the date of this Agreement, MSI has not
         engaged in any transaction which, if done after execution of
         this Agreement, would violate Section 5.3(c) hereof except as
         described or reflected in the MSI SEC Documents.  Since Septem-
         ber 30, 1994, no terminations, nonrenewals or amendments have
         occurred with respect to any Contract with any franchisee or
         licensee of Proprietary Rights of MSI that, individually or in
         the aggregate, could reasonably be expected to have a material
         adverse effect on MSI.  

                   4.25  Permits; Compliance.  MSI is in possession of
         all material franchises, grants, authorizations, licenses, per-
         mits, easements, variances, exemptions, consents, certificates,
         approvals and orders necessary to own, lease and operate its
         properties and to carry on its business as it is now being con-
         ducted (collectively, the "MSI Permits"), and, except as set
         forth in Section 4.25 to the MSI Disclosure Schedule, there is
         no Action pending or, to the knowledge of MSI, threatened re-
         garding suspension or cancellation of any of the MSI Permits,
         except for any such Action which, if determined adversely,
         could not reasonably be expected, individually or in the ag-
         gregate, to have a material adverse effect on MSI.  Except as
         set forth in Section 4.25 to the MSI Disclosure Schedule, MSI
         is not in conflict with, or in default or violation of, (a) any
         franchise disclosure or relationships law, (b) any other Ap-
         plicable Law (including, without limitation, the Prescription
         Drug Marketing Act, the Federal Controlled Substances Act of
         1970, tit. II, 84 Stat. 1242, the Food, Drug and Cosmetic Act,
         21 U.S.C. Sec. 301 et seq., and any state Pharmacy Practice
         Acts, Controlled Substances Acts, Dangerous Drug Acts and Food,
         Drug and Cosmetic Acts and all rules of professional conduct
         applicable thereto and applicable to MSI or by which any of its
         properties is bound or subject or (c) any of the MSI Permits,
         except in the case of clauses (b) and (c) for any such con-
         flicts, defaults or violations which, individually or in the
         aggregate, could not reasonably be expected to have a material
         adverse effect on MSI.  During the period commencing on Septem-
         ber 30, 1992 and ending on the date hereof, MSI has not re-
         ceived any notification with respect to possible conflicts,
         defaults or violations of (a) franchise disclosure or relation-
         ships laws or (b) other Applicable Laws, except in the case of
         clause (b) for notices relating to possible conflicts, defaults
         or violations, which conflicts, defaults or violations could
         not reasonably be expected to have a material adverse effect on
         MSI.



                                       -28-<PAGE>







                   4.26  Product Warranties and Liabilities.  Except as
         set forth in Section 4.26 to the MSI Disclosure Schedule, MSI
         has no forms of warranties or guarantees of its products and
         services that are in effect or proposed to be used by it.  Sec-
         tion 4.26 to the MSI Disclosure Schedule sets forth a descrip-
         tion of each pending or, to the knowledge of MSI, threatened
         material Action under any warranty or guaranty against MSI.
         MSI has not incurred, nor does MSI know or have any reason to
         believe there is any basis for alleging, any material li-
         ability, damage, loss, cost or expense as a result of any de-
         fect or other deficiency (whether of design, materials, work-
         manship, labeling instructions or otherwise) ("Product Li-
         ability") with respect to any product sold or services rendered
         by or on behalf of MSI prior to the Effective Time, whether
         such Product Liability is incurred by reason of any express
         warranty (including, without limitation, any warranty of mer-
         chantability or fitness), any doctrine of common law (tort,
         contract or other), any statutory provision or otherwise and
         irrespective of whether such Product Liability is covered by
         insurance.

                   4.27  Environmental Matters.

                   (a)  As used herein, the term "Environmental Laws"
         means all federal, state, local or foreign laws relating to
         pollution or protection of human health or the environment (in-
         cluding, without limitation, ambient air, surface water,
         groundwater, land surface or subsurface strata), including,
         without limitation, laws relating to emissions, discharges,
         releases or threatened releases of chemicals, pollutants, con-
         taminants, or industrial, toxic or hazardous substances or
         wastes (collectively, "Hazardous Materials") into the environ-
         ment, or otherwise relating to the manufacture, processing,
         distribution, use, treatment, storage, disposal, transport or
         handling of Hazardous Materials, as well as all authorizations,
         codes, decrees, demands or demand letters, injunctions, judg-
         ments, licenses, notices or notice letters, orders, permits,
         plans or regulations issued, entered, promulgated or approved
         thereunder.

                   (b)  To the knowledge of MSI, there are, with respect
         to MSI, or its subsidiaries, no past or present material viola-
         tions of Environmental Laws, releases of any Hazardous Material
         into the environment, actions, activities, circumstances, con-
         ditions, events, incidents, or contractual obligations which
         may give rise to any common law environmental liability or any
         liability under the Comprehensive Environmental Response, Com-
         pensation and Liability Act of 1980 or similar federal, state,
         local or foreign laws and none of MSI and its subsidiaries has
         received any notice with respect to any of the foregoing, nor 



                                       -29-<PAGE>







         is any Action pending or threatened in connection with any of
         the foregoing.

                   (c)  To the knowledge of MSI, no Hazardous Materials
         were or are contained on or about any real property owned or
         leased by MSI or any of its subsidiaries, except as in the nor-
         mal course of MSI's business.

                   (d)  To the knowledge of MSI, there are no under-
         ground storage tanks on or under any real property owned or
         leased by MSI or any of its subsidiaries.  

                   4.28  OSHA Matters.  MSI is in compliance with the
         requirements of the Occupational Safety and Health Act and the
         regulations promulgated thereunder and any similar laws or reg-
         ulations of any foreign, state or local jurisdiction ("OSHA"),
         except for any non-compliance which could not reasonably be
         expected to have, individually or in the aggregate, a material
         adverse effect on MSI.  MSI has not received any citation from
         the Occupational Safety and Health Administration or any other
         Governmental Authority or any inspector setting forth any re-
         spect in which the facilities or operations of MSI are not in
         compliance with OSHA, or the regulations under such act, which
         noncompliance has not been corrected or remedied to the satis-
         faction of such Governmental Authority or inspector, except in
         all such cases for any noncompliance that could not reasonably
         be expected to have, individually or in the aggregate, a mate-
         rial adverse effect on MSI.  MSI has heretofore provided Cardi-
         nal with copies of all citations heretofore issued to MSI under
         OSHA and copies of all material correspondence from and to the
         Occupational Safety and Health Administration, any other Gov-
         ernmental Authority and any inspectors during the past three
         (3) years.

                   4.29  Insurance.  Section 4.29 to the MSI Disclosure
         Schedule lists all material insurance policies and binders and
         programs of self-insurance owned, held or maintained by MSI on
         the date hereof and which afford coverage to MSI, its assets or
         business.  As of the date hereof, all such policies, binders
         and programs are in full force and effect, and, as of the Ef-
         fective Time, all such policies, binders and programs (or re-
         newals or replacements thereof, as applicable) will be in full
         force and effect.  All premiums with respect thereto covering
         all periods up to and including the date hereof have been paid
         to the extent due, and, as of the Effective Time, all premiums
         with respect thereto (or with respect to renewals or replace-
         ments thereof, as applicable) will be paid to the extent due.
         As of the date hereof, no notice of cancellation or termination
         has been received with respect to any such policy or binder (or
         the renewals or replacements thereof, as applicable) and, as of 



                                       -30-<PAGE>







         the Effective Time, no notice of cancellation or termination
         will have been received with respect to any such policy or
         binder (or the renewals or replacements thereof, as applica-
         ble).

                   4.30  Opinion of Financial Advisor.  MSI has received
         the oral opinion (and prior to the close of business on Septem-
         ber 5, 1995 will have received, and delivered to Cardinal a
         copy of a written opinion) of Kemper Securities Incorporated,
         its financial advisor, to the effect that, as of August 26,
         1995, the Exchange Ratio is fair to the MSI Shareholders from a
         financial point of view. 

                   4.31  Board Recommendation.  Prior to the execution
         of this Agreement, the Stock Option Agreement and any Support
         Agreement, the Board of Directors of MSI, at a meeting duly
         called and held, has by the required vote (i) determined that
         this Agreement and the transactions contemplated hereby, in-
         cluding the Merger, and the Stock Option Agreement and the
         transactions contemplated thereby, taken together, are fair to
         and in the best interests of the stockholders of MSI, and (ii)
         resolved to recommend that the holders of the shares of MSI
         Common Stock approve this Agreement and the transactions con-
         templated herein, including the Merger.

                   4.32  DGCL Section 203 and Missouri Takeover Laws.
         Assuming the accuracy of the representation contained in Sec-
         tion 3.11, (x) the restrictions contained in Section 203 of the
         DGCL will not and do not apply to, and (y) no provision of any
         statute of the State of Missouri that purports to limit or re-
         strict business combinations or the ability to acquire or vote
         shares will apply to:  (i) the execution of this Agreement, the
         Stock Option Agreement dated as of August 26, 1995 between Car-
         dinal and MSI (the "Stock Option Agreement"), the Support/
         Voting Agreements dated as of August 26, 1995 between Cardinal
         and certain MSI Shareholders (collectively, the "Support Agree-
         ments"), (ii) the Merger and (iii) the transactions contem-
         plated hereby and by the Stock Option Agreement and the Support
         Agreements.

                   4.33  Franchise Agreements.

                   (a)  Except as set forth in Section 4.33 to the MSI
         Disclosure Schedule, there are no master franchisees ("Master
         Franchisees") who have been granted the right to use, purchase
         or license Proprietary Rights, goods or services from MSI and 







                                       -31-<PAGE>







         to provide, resell or relicense same to other authorized fran-
         chisees or third parties.  The identity of each Master Franchi-
         see is set forth in Section 4.33 to the MSI Disclosure Sched-
         ule.  A supplement to Section 4.33 to the MSI Disclosure Sched-
         ule to be delivered by MSI to Cardinal within 21 days from the
         date hereof will set forth a description of all franchisees and
         third parties to whom Master Franchisees are entitled to pro-
         vide, resell or relicense Proprietary Rights, goods and ser-
         vices of MSI.  There are no agreements between MSI and any Mas-
         ter Franchisee other than those in writing that are set forth
         in Section 4.33 to the MSI Disclosure Schedule.

                   (b)  Except as set forth in Section 4.33 to the MSI
         Disclosure Schedule, as of the date of this Agreement, neither
         MSI nor, to the best knowledge of MSI, any franchisee or Master
         Franchisee is in default under or is in material breach of any
         terms, conditions, covenants or obligations of the relationship
         between any of them which default or material breach is reason-
         ably likely to lead to termination of any franchise agreement
         between any of them.

                   (c)  The relationships of MSI with its franchisees
         are generally satisfactory.  As of the Effective Time, the
         Threshold Franchises (as defined in Section 4.33(c) to the MSI
         Disclosure Schedule) shall not have ceased to be franchisees of
         MSI, nor have threatened, nor have been threatened by MSI, in
         writing to terminate such status since June 30, 1995.

                   (d)  MSI has timely filed with the appropriate Gov-
         ernmental Authorities and has heretofore made available to Car-
         dinal true, correct and complete copies of all forms, reports,
         schedules, statements and other documents required to be filed
         by it since June 30, 1992 under any franchise disclosure or
         relationships law, including, without limitation, the filing of
         any Uniform Franchise Offering Circular as required by federal
         regulations and state disclosure laws (such documents, as
         amended since the time of filing, collectively, the "MSI Fran-
         chise Documents").  The MSI Franchise Documents, including,
         without limitation, any schedules included therein, at the time
         filed, as of the date hereof and at the Effective Time (a) did
         not, do not and will not contain any untrue statement of a ma-
         terial fact or omit to state a material fact required to be
         stated therein or necessary in order to make the statements
         therein, in light of the circumstances under which they were
         made, not misleading, and (b) complied, comply and will comply
         in all material respects with the applicable requirements of
         any franchise disclosure or relationships law.

                   4.34  Employment Agreement.  The Employment Agree-
         ment, dated the date hereof, between Cardinal and David A. 



                                       -32-<PAGE>







         Abrahamson, (i) has been duly executed and delivered by Mr.
         Abrahamson and (ii) as of the Effective Time, shall not have
         been terminated since the date hereof.

                   4.35  Investment Company.  MSI is not an "investment
         company" within the meaning of the Investment Company Act of
         1940, as amended.


                                    ARTICLE V

                             COVENANTS OF THE PARTIES

                   The parties hereto agree as follows with respect to
         the period from and after the execution of this Agreement.

                   5.1  Mutual Covenants.

                   (a)  General.  Each of the parties shall use its rea-
         sonable efforts to take all action and to do all things neces-
         sary, proper or advisable to consummate the Merger and the
         transactions contemplated by this Agreement (including, without
         limitation, using its reasonable efforts to cause the condi-
         tions set forth in Article VI for which they are responsible to
         be satisfied as soon as reasonably practicable and to prepare,
         execute and deliver such further instruments and take or cause
         to be taken such other and further action as any other party
         hereto shall reasonably request).

                   (b)  HSR Act.  As soon as practicable, and in any
         event no later than fifteen (15) business days after the date
         hereof, each of the parties hereto will file any Notification
         and Report Forms and related material required to be filed by
         it with the Federal Trade Commission and the Antitrust Division
         of the United States Department of Justice under the HSR Act
         with respect to the Merger, will use its reasonable efforts to
         obtain an early termination of the applicable waiting period,
         and shall promptly make any further filings pursuant thereto
         that may be necessary, proper or advisable; provided, however,
         that neither Cardinal nor any of its subsidiaries shall be re-
         quired hereunder to divest or hold separate any portion of
         their business or assets.  

                   (c)  Other Governmental Matters.  Each of the parties
         shall use its reasonable efforts to take any additional action
         that may be necessary, proper or advisable in connection with
         any other notices to, filings with, and authorizations, con-
         sents and approvals of any Governmental Authority that it may
         be required to give, make or obtain.




                                       -33-<PAGE>







                   (d)  Pooling-of-Interests and Tax-Free Treatment.
         Each of the parties shall use its reasonable efforts to cause
         the Merger to (i) qualify for pooling-of-interest accounting
         treatment for financial reporting purposes and (ii) constitute
         a tax-free "reorganization" under Section 368(a)(2)(E) of the
         Code and to permit Gallop, Johnson & Neuman, LC to issue its
         opinion provided for in Section 6.1(e).  

                   (e)  Public Announcements.  Unless otherwise required
         by Applicable Laws or requirements of the National Association
         of Securities Dealers or the NYSE (and in that event only if
         time does not permit), at all times prior to the earlier of the
         Effective Time or termination of this Agreement pursuant to
         Section 7.1, Cardinal and MSI shall consult with each other
         before issuing any press release with respect to the Merger and
         shall not issue any such press release prior to such consulta-
         tion.

                   (f)  Access.  From and after the date of this agree-
         ment until the Effective Time (or the termination of this
         Agreement), Cardinal and MSI shall permit representatives of
         the other to have appropriate access at all reasonable times to
         the other's premises, properties, books, records, contracts,
         tax records, documents, customers and suppliers.  Information
         obtained by Cardinal and MSI pursuant to this Section 5.1(f)
         shall be subject to the provisions of the confidentiality
         agreement between them dated August 2, 1995 (the "Confidential-
         ity Agreement"), which agreement remains in full force and ef-
         fect.

                   5.2  Covenants of Cardinal.

                   (a)  Preparation of Cardinal Registration Statement.
         Cardinal shall prepare and file the Registration Statement with
         the Commission as soon as is reasonably practicable following
         clearance of the Proxy Statement by the Commission and shall
         use all reasonable efforts to have the Registration Statement
         relate to all Cardinal Common Shares to be issued to MSI Share-
         holders as a result of the Merger (other than Cardinal Exchange
         Restricted Stock and Cardinal Common Shares issuable upon exer-
         cise of Cardinal Exchange Options) and to be declared effective
         by the Commission as promptly as practicable and to maintain
         the effectiveness of the Registration Statement through the
         Effective Time.  Cardinal also shall take such other action
         (other than qualifying to do business in any jurisdiction in
         which it is not so qualified) required to be taken under any
         applicable state securities laws in connection with the issu-
         ance of Cardinal Common Shares in the Merger.





                                       -34-<PAGE>







                   (b)  Conduct of Cardinal's Operations.  During the
         period from the date of this Agreement to the Effective Time,
         Cardinal shall use its reasonable efforts to maintain and pre-
         serve its business organization and to retain the services of
         its officers and key employees and maintain relationships with
         customers, suppliers and other third parties to the end that
         their goodwill and ongoing business shall not be impaired in
         any material respect.  

                   (c)  Directors' and Officers' Insurance.  Cardinal
         agrees to use its reasonable efforts to cause the Surviving
         Corporation to maintain in effect for not less than three years
         after the Effective Time the current policies of directors' and
         officers' liability insurance maintained by MSI with respect to
         matters occurring prior to the Effective Time; provided, how-
         ever, that (i) the Surviving Corporation may substitute there-
         for policies of at least the same coverage containing terms and
         conditions which are no less advantageous to the covered offic-
         ers and directors and (ii) the Surviving Corporation shall not
         be required to pay an annual premium for such insurance in ex-
         cess of two times the last annual premium paid prior to the
         date hereof, but in such case shall purchase as much coverage
         as possible for such amount.

                   (d)  Indemnification.  From and after the Effective
         Time, Cardinal shall cause the Surviving Corporation (includ-
         ing, providing adequate funding) to indemnify and hold harm-
         less, pursuant to the procedures set forth in Exhibit D to this
         Agreement, the present and former officers and directors of MSI
         in respect of acts or omissions occurring prior to the Effec-
         tive Time to the fullest extent provided under the MSI Cer-
         tificate of Incorporation, as amended, and MSI Bylaws in effect
         on the date hereof.

                   (e)  Employee Benefits.  Cardinal covenants and
         agrees that, for a period of two years from and after the Ef-
         fective Time, it will cause the Surviving Corporation to pro-
         vide for the benefit of employees of the Surviving Corporation
         benefits that are no less favorable, in the aggregate, as those
         provided to employees of MSI immediately prior to the date of
         this Agreement.

                   (f)  Headquarters and Name.  Cardinal intends to
         cause the Surviving Corporation to (i) retain its corporate and
         business headquarters in St. Louis County, Missouri and
         (ii) continue to use the name "Medicine Shoppe International"
         as its corporate and business name.






                                       -35-<PAGE>







                   5.3  Covenants of MSI.

                   (a)  MSI Shareholders Meeting.  Subject to the provi-
         sions of Section 5.3(d), MSI shall take all action in ac-
         cordance with the federal securities laws, the DGCL and its
         Certificate of Incorporation, as amended, and Bylaws necessary
         to obtain the consent and approval of MSI Shareholders with
         respect to the Merger, this Agreement and the transactions con-
         templated hereby.

                   (b)  Information for the Registration Statement and
         Preparation of MSI Proxy Statement.  MSI shall furnish Cardinal
         with all information concerning it as may be required for in-
         clusion in the Registration Statement.  MSI shall cooperate
         with Cardinal in the preparation of the Registration Statement
         in a timely fashion and shall use all reasonable efforts to
         have the Registration Statement declared effective by the Com-
         mission as promptly as practicable.  If at any time prior to
         the Effective Time, any information pertaining to MSI contained
         in or omitted from the Registration Statement makes such state-
         ments contained in the Registration Statement false or mislead-
         ing, MSI shall promptly so inform Cardinal and provide Cardinal
         with the information necessary to make statements contained
         therein not false and misleading.  MSI shall, as soon as is
         reasonably practicable, prepare and file the Proxy Statement
         with the Commission on a confidential basis.  MSI shall use all
         reasonable efforts to mail at the earliest practicable date to
         MSI Shareholders the Proxy Statement, which shall include all
         information required under applicable law to be furnished to
         MSI Shareholders in connection with the Merger and the transac-
         tions contemplated thereby and shall include the recommendation
         of MSI's Board of Directors in favor of the Merger unless the
         Board of Directors of MSI determines in good faith upon advice
         of its outside legal counsel, that it is obligated by prin-
         ciples of fiduciary duty not to make such recommendation.

                   (c)  Conduct of MSI's Operations.  During the period
         from the date of this Agreement to the Effective Time, MSI
         shall conduct its operations in the ordinary course except as
         expressly contemplated by this Agreement and the transactions
         contemplated hereby and shall use its reasonable efforts to
         maintain and preserve its business organization and its mate-
         rial rights and franchises and to retain the services of its
         officers and key employees and maintain relationships with cus-
         tomers, suppliers, franchisees, Master Franchisees, licensees
         and other third parties to the end that their goodwill and on-
         going business shall not be impaired in any material respect.
         Without limiting the generality of the foregoing, during the
         period from the date of this Agreement to the Effective Time,
         MSI shall not, except as otherwise expressly contemplated by 



                                       -36-<PAGE>







         this Agreement, the Stock Option Agreement and the transactions
         contemplated hereby and thereby or as set forth in Section
         5.3(c) to the MSI Disclosure Schedule, without the prior writ-
         ten consent of Cardinal:

                   (i)  do or effect any of the following actions with
              respect to its securities:  (A) adjust, split, combine or
              reclassify its capital stock, (B) make, declare or pay any
              dividend or distribution on, or directly or indirectly
              redeem, purchase or otherwise acquire, any shares of its
              capital stock or any securities or obligations convertible
              into or exchangeable for any shares of its capital stock,
              except dividends on the MSI Common Stock, at a rate of not
              more than $.14 per share per quarter, with a record and
              payment date in accordance with recent practice, (C) grant
              any person any right to acquire any shares of its capital
              stock, (D) issue, deliver or sell or agree to issue, de-
              liver or sell any additional shares of its capital stock
              or any securities or obligations convertible into or ex-
              changeable or exercisable for any shares of its capital
              stock or such securities (except pursuant to the exercise
              of outstanding options to purchase MSI Common Stock), or
              (E) enter into any agreement, understanding or arrangement
              with respect to the sale or voting of its capital stock;

                  (ii)  sell, transfer, pledge, mortgage, encumber or
              otherwise dispose of any of its property or assets other
              than (A) sales of inventory, licensing of Proprietary
              Rights or other actions made in the ordinary course of
              business or (B) any such other dispositions as are not,
              individually or in the aggregate, material to the busi-
              ness, assets or properties of MSI and are, in each case,
              consistent with past practice;

                 (iii)  make or propose any changes in its Certificate
              of Incorporation, as amended, or Bylaws;

                  (iv)  merge or consolidate with any other person or
              acquire a material amount of assets or capital stock of
              any other person or enter into any confidentiality agree-
              ment, other than in the ordinary course of business and
              consistent with past practice, with any person (other than
              as permitted by Section 5.3(d));










                                       -37-<PAGE>







                   (v)  incur, create, assume or otherwise become liable
              for any indebtedness for borrowed money or assume, guaran-
              tee, endorse or otherwise as an accommodation become re-
              sponsible or liable for the obligations of any other indi-
              vidual, corporation or other entity other than the financ-
              ing of franchisees in the ordinary course of business con-
              sistent with past practice;

                  (vi)  create any subsidiaries;

                 (vii)  enter into or modify any employment, severance,
              termination or similar agreements or arrangements with, or
              grant or provide any bonuses, salary increases, other com-
              pensation, benefits, severance or termination pay to, any
              officer, director, consultant or employee, other than sal-
              ary increases and bonuses granted in the ordinary course
              of business consistent with past practice, but in any
              event, for any person not greater than 110% of the ag-
              gregate of such person's previous year's salary and annual
              bonus, or exercise any discretionary power to cause any
              options to become exercisable or any restricted stock or
              other compensation to become vested, except in each case
              as may be required by Applicable Law or a binding written
              contract in effect on the date of this Agreement;

                (viii)  change its method of doing business or change
              any method or principle of accounting in a manner that is
              inconsistent with past practice;

                  (ix)  settle any Actions, whether now pending or here-
              after made or brought involving an amount in excess of
              $50,000;

                   (x)  modify, amend or terminate, or waive, release or
              assign any material rights or claims with respect to, any
              Contract set forth in Section 4.17 to the MSI Disclosure
              Schedule, any other material Contract to which MSI is a
              party or any confidentiality agreement to which MSI is a
              party;

                  (xi)  incur or commit to any capital expenditures,
              obligations or liabilities in respect thereof which in the
              aggregate exceed or would exceed $200,000;

                 (xii)  make any material changes or modifications to
              any pricing policy (including franchise royalties and
              fees) or investment policy or enter into any new franchise
              or Master Franchise relationship on terms different from
              those in effect in the ordinary and usual course of busi-
              ness, consistent with past practice;



                                       -38-<PAGE>







                (xiii)  except with respect to any Merger Fees directly
              incurred in connection with a proposal relating to a Com-
              peting Transaction, pay any Merger Fees materially in ex-
              cess of the amount set forth in Section 4.14 to the MSI
              Disclosure Schedule unless (A) MSI shall have given prior
              notice of any such payment to the General Counsel of Car-
              dinal and (B) the amount so paid shall be reasonable in
              relation to the value of the services rendered, based on
              general standards in the relevant industry;

                 (xiv)  take any action to exempt or make inapplicable
              under (x) Section 203 of the DGCL or (y) any other state
              takeover law or state law that purports to limit or re-
              strict business combinations or the ability to acquire or
              vote shares, any person or entity (other than Cardinal or
              its subsidiaries) or any action taken thereby, which per-
              son, entity or action would have otherwise been subject to
              the restrictive provisions thereof and not exempt there-
              from;

                  (xv)  enter into or carry out any other material
              transaction other than in the ordinary and usual course of
              business; 

                 (xvi)  permit or cause any subsidiary to do any of the
              foregoing or agree or commit to do any of the foregoing;
              or

                (xvii)  agree in writing or otherwise to take any of the
              foregoing actions.

                   (d)  No Solicitation.  MSI agrees that, during the
         term of this Agreement, it shall not, and shall not authorize
         or permit any of its subsidiaries or any of its or its subsid-
         iaries' directors, officers, employees, agents or representa-
         tives, directly or indirectly, to solicit, initiate, encourage
         or facilitate, or furnish or disclose non-public information in
         furtherance of, any inquiries or the making of any proposal
         with respect to any recapitalization, merger, consolidation or
         other business combination involving MSI, or acquisition of any
         capital stock or any material portion of the assets (except for
         acquisition of assets in the ordinary course of business con-
         sistent with past practice) of MSI, or any combination of the
         foregoing (a "Competing Transaction"), or negotiate, explore or
         otherwise engage in discussions with any person (other than
         Cardinal, Subcorp or their respective directors, officers, em-
         ployees, agents and representatives) with respect to any Com-
         peting Transaction or enter into any agreement, arrangement or
         understanding requiring it to abandon, terminate or fail to
         consummate the Merger or any other transactions contemplated by 



                                       -39-<PAGE>







         this Agreement; provided that in the event MSI receives any
         written proposal from any third party relating to a Competing
         Transaction that the Board of Directors of MSI determines in
         good faith, upon advice of its outside legal counsel, it is
         obligated by principles of fiduciary duty to consider, MSI,
         without violating any provisions of this Agreement, may furnish
         or disclose non-public information to, and may enter into dis-
         cussions and negotiations with, such third party.  If the Board
         of Directors of MSI shall thereupon or thereafter determine in
         good faith, after consultation with its financial and legal
         advisors, that any such written proposal from a third party for
         a Competing Transaction, as the same may have been refined and
         revised in writing as a result of any such discussions and ne-
         gotiations, is more favorable to the MSI Shareholders from a
         financial point of view than the transactions contemplated by
         this Agreement (including any adjustment to the terms and con-
         ditions of such transaction proposed by Cardinal in response to
         such Competing Transaction) and is in the best interest of the
         MSI Shareholders, MSI may terminate this Agreement and enter
         into an agreement with respect to such Competing Transaction
         provided that, prior to any such termination, (i) MSI has pro-
         vided Cardinal written notice that it intends to terminate this
         Agreement pursuant to this Section 5.3(d), identifying the Com-
         peting Transaction then determined to be more favorable, and
         (ii) at least two full business days after MSI has provided the
         notice referred to in clause (i) above, MSI delivers to Cardi-
         nal (A) a written notice of termination of this Agreement pur-
         suant to this Section 5.3(d), (B) a check in the amount of
         Cardinal's Costs (as defined in Section 7.2) as provided in
         Section 7.2 as the same may have been estimated by Cardinal in
         good faith prior to the date of such delivery (subject to an
         adjustment payment between the parties upon Cardinal's defini-
         tive determination of such Costs), (C) a written acknowledgment
         from MSI that (x) the termination of this Agreement and the
         entry into the agreement for the Competing Transaction will be
         a "Purchase Event" as defined in the Stock Option Agreement and
         (y) the Stock Option Agreement shall be honored in accordance
         with its terms and (D) a written acknowledgment from each other
         party to such Competing Transaction that it is aware of the
         substance of MSI's acknowledgment under clause (C) above and
         waives any right it may have to contest the matters thus ac-
         knowledged by MSI.  During the term of this Agreement, MSI
         shall immediately advise Cardinal in writing of the receipt,
         directly or indirectly, of any inquiries or proposals relating
         to a Competing Transaction and promptly furnish to Cardinal a
         copy of any such inquiry or proposal (and any revisions or re-
         finements thereof) in addition to (x) any non-confidential
         written information received from or on behalf of any other
         party to such Competing Transaction necessary to a full and 




                                       -40-<PAGE>







         fair understanding of the proposal for the Competing Transac-
         tion and (y) any information provided by MSI to any such other
         party relating to such proposal.

                   (e)  Affiliates of MSI.  MSI shall use its best ef-
         forts to cause each such person who may be at the Effective
         Time or was on the date hereof an "affiliate" of MSI for pur-
         poses of Rule 145 under the Securities Act, to execute and de-
         liver to Cardinal as soon as practicable and in no event no
         less than 35 days prior to the date of the meeting of MSI
         Shareholders to approve the Merger, the written undertakings in
         the form attached hereto as Exhibit A.

                   (f)  Notification of Certain Matters.  MSI shall give
         prompt notice to Cardinal of (i) the occurrence or nonoccur-
         rence of any event the occurrence or nonoccurrence of which
         would cause any representation or warranty contained in this
         Agreement to be untrue or inaccurate at or prior to the Effec-
         tive Time and (ii) any material failure of MSI to comply with
         or satisfy any covenant, condition or agreement to be complied
         with or satisfied by it hereunder; provided, however, that the
         delivery of any notice pursuant to this Section 5.3(f) shall
         not limit or otherwise affect the remedies available hereunder
         to Cardinal.


                                    ARTICLE VI

                                    CONDITIONS

                   6.1  Mutual Conditions.  The obligations of the par-
         ties hereto to consummate the Merger shall be subject to ful-
         fillment of the following conditions:

                   (a)  No temporary restraining order, preliminary or
              permanent injunction or other order or decree which pre-
              vents the consummation of the Merger shall have been is-
              sued and remain in effect, and no statute, rule or regu-
              lation shall have been enacted by any Governmental Author-
              ity which prevents the consummation of the Merger.

                   (b)  All waiting periods applicable to the consumma-
              tion of the Merger under the HSR Act shall have expired or
              been terminated.

                   (c)  The Merger and the transactions contemplated
              hereby shall have been approved by the MSI Shareholders in
              the manner required by any Applicable Law.





                                       -41-<PAGE>







                   (d)  The Commission shall have declared the Cardinal
              Registration Statement effective.  On the Closing Date and
              at the Effective Time, no stop order or similar restrain-
              ing order shall have been threatened by the Commission or
              entered by the Commission or any state securities admin-
              istrator prohibiting the Merger.

                   (e)  MSI shall have received an opinion of Gallop,
              Johnson & Neuman, L.C. substantially to the effect that,
              under applicable law, for Federal income tax purposes, the
              Merger will constitute a reorganization under Section 368
              of the Code.

                   (f)  Cardinal shall have received a letter, in form
              and substance reasonably satisfactory to Cardinal, from
              Deloitte & Touche LLP dated the date of the Proxy State-
              ment and confirmed in writing at the Effective Time stat-
              ing that the Merger will qualify as a pooling of interests
              transaction under Opinion 16 of the Accounting Principles
              Board.

                   (g)  No Action shall be instituted (x) by any Govern-
              mental Authority which seeks to prevent consummation of
              the Merger or (y) which is reasonably likely to result in
              material damages in connection with the transactions
              contemplated hereby which, in each case, continues to be
              outstanding.

                   6.2  Conditions to Obligations of MSI.  The obliga-
         tions of MSI to consummate the Merger and the transactions con-
         templated hereby shall be subject to the fulfillment of the
         following conditions unless waived by MSI:

                   (a)  Each of the representations and warranties of
              each of Cardinal and Subcorp set forth in Article III
              shall be true and correct in all material respects on the
              date hereof and on and as of the Closing Date as though
              made on and as of the Closing Date (except for represen-
              tations and warranties made as of a specified date, which
              need be true and correct only as of the specified date).  

                   (b)  Each of Cardinal and Subcorp shall have per-
              formed in all material respects each obligation and agree-
              ment and shall have complied in all material respects with
              each covenant to be performed and complied with by it
              hereunder at or prior to the Effective Time.

                   (c)  Each of Cardinal and Subcorp shall have fur-
              nished MSI with a certificate dated the Closing Date
              signed on behalf of it by the Chairman, President or any 



                                       -42-<PAGE>







              Vice President to the effect that the conditions set forth
              in Sections 6.2(a) and (b) have been satisfied.

                   (d)  MSI shall have received the legal opinion, dated
              the Closing Date, of Wachtell, Lipton, Rosen & Katz, spe-
              cial counsel to Cardinal, in substantially the form at-
              tached hereto as Exhibit B.

                   (e)  The Cardinal Common Shares to be issued in the
              Merger shall have been authorized for inclusion on the
              NYSE, subject to official notice of issuance.

                   6.3  Conditions to Obligations of Cardinal and Sub-
         corp.  The obligations of Cardinal to consummate the Merger and
         the other transactions contemplated hereby shall be subject to
         the fulfillment of the following conditions unless waived by
         each of Cardinal and Subcorp:

                   (a)  Each of the representations and warranties of
              MSI set forth in Article IV shall be true and correct in
              all material respects on the date hereof and on and as of
              the Closing Date as though made on and as of the Closing
              Date (except for representations and warranties made as of
              a specified date, which need be true and correct only as
              of the specified date).  

                   (b)  MSI shall have performed in all material re-
              spects each obligation and agreement and shall have com-
              plied in all material respects with each covenant to be
              performed and complied with by it hereunder at or prior to
              the Effective Time.

                   (c)  MSI shall have furnished Cardinal with a cer-
              tificate dated the Closing Date signed on its behalf by
              its Chairman, President or any Vice President to the ef-
              fect that the conditions set forth in Sections 6.3(a) and
              (b) have been satisfied.

                   (d)  Cardinal shall have received the legal opinion,
              dated the Closing Date, of Gallop, Johnson & Neuman, L.C.,
              substantially in the form attached hereto as Exhibit C.

                   (e)  The Employment Agreement, dated the date hereof,
              between Cardinal and David A. Abrahamson shall be in full
              force and effect and shall not have been terminated.

                   (f)  Each person who may be at the Effective Time or
              was on the date of this Agreement an "affiliate" of MSI
              for purposes of Rule 145 under the Securities Act, shall
              have executed and delivered to Cardinal at least 35 days 



                                       -43-<PAGE>







              prior to the date of the meeting of MSI Shareholders to
              approve the Merger the written undertakings in the form
              attached hereto as Exhibit A. 

                   (g)  There shall not have been a breach of any obli-
              gation by any stockholder which has entered into a Support
              Agreement or by MSI of the Stock Option Agreement.

                   (h)  All actions shall have been taken necessary to
              exempt or make inapplicable under (x) Section 203 of the
              DGCL and (y) any other state takeover law or state law
              that purports to limit or restrict business combinations
              or the ability to acquire or vote shares:  (i) the execu-
              tion of this Agreement, the Stock Option Agreement and the
              Support Agreements, (ii) the Merger and (iii) the transac-
              tions contemplated hereby and by the Stock Option Agree-
              ment and the Support Agreements.


                                   ARTICLE VII

                            TERMINATION AND AMENDMENT

                   7.1  Termination.  This Agreement may be terminated
         at any time prior to the Effective Time, whether before or af-
         ter approval and adoption of this Agreement by MSI Sharehold-
         ers:

                   (a)  by mutual consent of Cardinal and MSI;

                   (b)  by either Cardinal or MSI if any permanent in-
              junction or other order of a court or other competent Gov-
              ernmental Authority preventing the consummation of the
              Merger shall have become final and nonappealable;

                   (c)  by either Cardinal or MSI if the Merger shall
              not have been consummated before February 15, 1996, unless
              extended by the Boards of Directors of both Cardinal and
              MSI; provided, however, that a party shall not have a
              right to terminate this Agreement under this Section
              7.1(c) if such party's failure or such party's affiliate's
              failure to perform any material covenant or obligation
              under this Agreement has been the cause of or resulted in
              the failure of the Merger to occur on or before such date
              which failure constitutes a breach;

                   (d)  by MSI, within two days following the meeting of
              MSI Shareholders at which the vote to approve the Merger
              occurs, if the Average Share Price (calculated pursuant to
              Section 2.1(b) but assuming solely for purposes of such 



                                       -44-<PAGE>







              calculation that the Closing Date is the date of such
              meeting of MSI Shareholders) is less than $49.29, provided
              that Cardinal shall not have given written notice to MSI
              (an "Adjustment Election") no later than two days prior to
              such meeting of MSI Shareholders that the Base Share Price
              shall be adjusted pursuant to Section 2.1(b)(ii), if ap-
              plicable;

                   (e)  by either Cardinal or MSI, within two days fol-
              lowing the meeting of MSI Shareholders at which the vote
              to approve the Merger occurs, if the Average Share Price
              (calculated pursuant to Section 2.1(b) but assuming solely
              for purposes of such calculation that the Closing Date is
              the date of such meeting of MSI Shareholders) is less than
              $46.27;

                   (f)  by Cardinal if the Board of Directors of MSI
              shall withdraw, modify or change its recommendation of
              this Agreement or the Merger in a manner adverse to Cardi-
              nal, or if the Board of Directors of MSI shall have re-
              fused to affirm such recommendation within two days of any
              written request from Cardinal;

                   (g)  by either Cardinal or MSI if at the meeting of
              MSI Shareholders (including any adjournment or postpone-
              ment thereof) the requisite vote of the MSI Shareholders
              to approve the Merger and the transactions contemplated
              hereby shall not have been obtained;

                   (h)  by Cardinal if MSI shall have breached any of
              its obligations under the Stock Option Agreement;

                   (i)  by Cardinal if any MSI Shareholder who is party
              to a Support Agreement shall have breached such Support
              Agreement, provided that MSI Shareholders shall not have
              approved the Merger and the transactions contemplated
              hereby; 

                   (j)  by MSI pursuant to Section 5.3(d); or

                   (k)  by either Cardinal or MSI in the event of a ma-
              terial breach by the other party of any representation,
              warranty, covenant or other agreement contained in this
              Agreement which (A) would give rise to the failure of a
              condition set forth in Sections 6.2(a) or 6.2(b) or Sec-
              tions 6.3(a) or 6.3(b) and (B) has not been cured within
              30 days after the giving of written notice to the breach-
              ing party of such material breach; provided, however, that
              a party shall not have a right to terminate this Agreement 




                                       -45-<PAGE>







              under this Section 7.1(k) if such party is then in mate-
              rial breach of any representation, warranty, covenant or
              other agreement contained in this Agreement.

                   7.2  Effect of Termination.  In the event of the ter-
         mination of this Agreement pursuant to Section 7.1, this Agree-
         ment, except for the provisions of the last sentence of Section
         5.1(f) and Sections 7.2 and 8.10, shall become void and have no
         effect, without any liability on the part of any party or its
         directors, officers or stockholders.  Notwithstanding the fore-
         going, nothing in this Section 7.2 shall relieve any party to
         this Agreement of liability for a material breach of any provi-
         sion of this Agreement and provided, further, however, that if
         it shall be judicially determined that termination of this
         Agreement was caused by an intentional breach of this Agree-
         ment, then, in addition to other remedies at law or equity for
         breach of this Agreement, the party so found to have intention-
         ally breached this Agreement shall indemnify and hold harmless
         the other parties for their respective costs, fees and expenses
         of their counsel, accountants, financial advisors and other
         experts and advisors as well as fees and expense incident to
         negotiation, preparation and execution of this Agreement and
         related documentation and shareholders' meetings and consents
         ("Costs") without reference to the limitation in the next sen-
         tence.  If this Agreement (A) is terminated for any reason pur-
         suant to Section 7.1 (other than (x) a termination pursuant to
         Section 7.1(a), Section 7.1(b), Section 7.1(c), Section 7.1(d),
         Section 7.1(e) or Section 7.1(g) or (y) a termination by MSI
         pursuant to Section 7.1(k)), (B) is terminated after the
         occurrence of a Prior Event (as defined in the Stock Option
         Agreement) pursuant to Section 7.1(g) or Section 7.1(c) (other
         than a termination by MSI pursuant to Section 7.1(c) if
         Cardinal's or Cardinal's affiliate's failure to perform any ma-
         terial covenant or obligation under this Agreement has been the
         cause of or resulted in the failure of the merger to occur on
         or before February 15, 1996, which failure constitutes a
         breach) and a Purchase Event (as defined in the Stock Option
         Agreement) shall have occurred within 12 months after such
         termination or (C) is terminated subsequent to a Purchase
         Event, MSI will promptly pay to Cardinal in reimbursement for
         Cardinal's expenses an amount in cash equal to the aggregate
         amount of Cardinal's Costs (which payment shall in no event
         exceed $1 million) incurred in connection with pursuing the
         transactions contemplated by this Agreement, including, without
         limitation, legal, accounting and investment banking fees.  

                   7.3  Amendment.  This Agreement may be amended by the
         parties hereto, by action taken or authorized by their respec-
         tive Boards of Directors, at any time before or after adoption 




                                       -46-<PAGE>







         of this Agreement by MSI Shareholders, but after any such ap-
         proval, no amendment shall be made which by law requires fur-
         ther approval by the MSI Shareholders without such further ap-
         proval.  Notwithstanding the foregoing, this Agreement may not
         be amended except by an instrument in writing signed on behalf
         of each of the parties hereto.

                   7.4  Extension; Waiver.  At any time prior to the
         Effective Time, Cardinal (with respect to MSI) and MSI (with
         respect to Cardinal and Subcorp) by action taken or authorized
         by their respective Boards of Directors or authorized officers,
         may, to the extent legally allowed, (a) extend the time for the
         performance of any of the obligations or other acts of such
         party, (b) waive any inaccuracies in the representations and
         warranties contained herein or in any document delivered pursu-
         ant hereto and (c) waive compliance with any of the agreements
         or conditions contained herein.  Any agreement on the part of a
         party hereto to any such extension or waiver shall be valid
         only if set forth in a written instrument signed on behalf of
         such party.


                                   ARTICLE VIII

                                  MISCELLANEOUS

                   8.1  Survival of Representations and Warranties.  The
         representations and warranties made herein by the parties here-
         to shall not survive the Effective Time.  This Section 8.1
         shall not limit any covenant or agreement of the parties here-
         to, which by its terms contemplates performance after the Ef-
         fective Time or the termination of this Agreement.

                   8.2  Notices.  All notices and other communications
         hereunder shall be in writing and shall be deemed given if de-
         livered personally, telecopied (which is confirmed) or dis-
         patched by a nationally recognized overnight courier service to
         the parties at the following addresses (or at such other ad-
         dress for a party as shall be specified by like notice):

                   (a)  if to Cardinal or Subcorp:

                        Cardinal Health, Inc.
                        655 Metro Place South
                        Suite 925
                        Dublin, Ohio  43017
                        Attention:  Robert D. Walter, Chairman
                        Telecopy No.:  (614) 761-8919





                                       -47-<PAGE>







                        with a copy to

                        David A. Katz
                        Wachtell, Lipton, Rosen & Katz
                        51 West 52nd Street
                        New York, New York  10019
                        Telecopy No.:  (212) 403-2000

                   (b)  if to MSI:

                        Medicine Shoppe International, Inc.
                        1100 N. Lindbergh
                        St. Louis, Missouri  63132
                        Attention:  David A. Abrahamson
                        Telecopy No.:  (314) 569-9780

                        with a copy to

                        Robert H. Wexler
                        Gallop, Johnson & Neuman, L.C.
                        Interco Corporate Tower
                        101 South Hanley
                        St. Louis, Missouri  63105
                        Telecopy No.:  (314) 862-1219

                   8.3  Interpretation.  When a reference is made in
         this Agreement to an Article or Section, such reference shall
         be to an Article or Section of this Agreement unless otherwise
         indicated.  The headings contained in this Agreement are for
         reference purposes only and shall not affect in any way the
         meaning or interpretation of this Agreement.  When a reference
         is made in this Agreement to MSI, such reference shall be
         deemed to include any and all subsidiaries of MSI, individually
         and in the aggregate, except for Sections 4.1, 4.2, 4.3, 4.4,
         4.5, 4.8, 4.16 and 4.27.  For the purposes of any provision of
         this agreement, a "material adverse effect" with respect to any
         party shall be deemed to occur if the aggregate consequences of
         all breaches and inaccuracies of covenants and representations
         of such party under this Agreement, when read without any ex-
         ception or qualification for a material adverse effect, are
         reasonably likely to have a material adverse effect on the as-
         sets, liabilities, results of operations or financial condition
         of such party and its subsidiaries taken as a whole.  

                   8.4  Counterparts.  This Agreement may be executed in
         counterparts, which together shall constitute one and the same
         Agreement.  The parties may execute more than one copy of the
         Agreement, each of which shall constitute an original.





                                       -48-<PAGE>







                   8.5  Entire Agreement.  This Agreement (including the
         documents and the instruments referred to herein), the Support
         Agreements, the Stock Option Agreement and the Confidentiality
         Agreement constitute the entire agreement among the parties and
         supersede all prior agreements and understandings, agreements
         or representations by or among the parties, written and oral,
         with respect to the subject matter hereof and thereof.

                   8.6  Third Party Beneficiaries.  Nothing in this
         Agreement, express or implied, is intended or shall be con-
         strued to create any third party beneficiaries other than Sec-
         tions 2.3 and 5.2(c) and (d).

                   8.7  Governing Law.  This Agreement shall be governed
         and construed in accordance with the laws of the State of Dela-
         ware without regard to principles of conflicts of law.

                   8.8  Specific Performance.  The transactions contem-
         plated by this Agreement are unique.  Accordingly, each of the
         parties acknowledges and agrees that, in addition to all other
         remedies to which it may be entitled, each of the parties here-
         to is entitled to a decree of specific performance, provided
         such party is not in material default hereunder.

                   8.9  Assignment.  Neither this Agreement nor any of
         the rights, interests or obligations hereunder shall be as-
         signed by any of the parties hereto (whether by operation of
         law or otherwise) without the prior written consent of the
         other parties.  Subject to the preceding sentence, this Agree-
         ment shall be binding upon, inure to the benefit of and be en-
         forceable by the parties and their respective successors and
         assigns.

                   8.10  Expenses.  Subject to the provisions of Section
         7.2 and of the Stock Option Agreement, Cardinal and MSI shall
         pay their own costs and expenses associated with the transac-
         tions contemplated by this Agreement.
















                                       -49-<PAGE>







                   IN WITNESS WHEREOF, Cardinal, Subcorp and MSI have
         signed this Agreement as of the date first written above.

                                    CARDINAL HEALTH, INC.


                                    By:  /s/ Robert D. Walter        



                                    ARCH MERGER CORP.


                                    By:  /s/ Robert D. Walter        



                                    MEDICINE SHOPPE INTERNATIONAL, INC.


                                    By:  /s/ David A. Abrahamson     

































                                       -50-









                             STOCK OPTION AGREEMENT


                   STOCK OPTION AGREEMENT ("Option Agreement") dated

         August 26, 1995, between CARDINAL HEALTH, INC. ("Cardinal"),

         an Ohio corporation and MEDICINE SHOPPE INTERNATIONAL, INC.

         ("MSI"), a Delaware corporation.


                              W I T N E S S E T H:


                   WHEREAS, the Board of Directors of Cardinal and the

         Board of Directors of MSI have approved an Agreement and Plan

         of Merger dated as of even date herewith (the "Merger Agree-

         ment") providing for the merger of a wholly owned subsidiary

         of Cardinal with and into MSI;


                   WHEREAS, as a condition and inducement to Cardi-

         nal's entering into the Merger Agreement, Cardinal has re-

         quired that MSI agree, and MSI has agreed, to grant to Car-

         dinal the option set forth herein to purchase authorized but

         unissued shares of MSI Common Stock;


                   NOW, THEREFORE, in consideration of the premises

         herein contained, the parties agree as follows:


                   1.  Definitions.


                   Capitalized terms used but not defined herein shall

         have the same meanings as in the Merger Agreement.  <PAGE>







                   2.  Grant of Option.


                   Subject to the terms and conditions set forth

         herein, MSI hereby grants to Cardinal an option (the "Op-

         tion") to purchase up to 1,300,000 authorized and unissued

         shares of MSI Common Stock at a price of $39.00 per share

         (the "Purchase Price") payable in cash as provided in Section

         4 hereof.


                   3.  Exercise of Option.


                   (a)  Cardinal may exercise the Option, in whole or

         in part, at any time or from time to time if a Purchase Event

         (as defined below) shall have occurred; provided, however,

         that, to the extent the Option shall not have been previously

         exercised, it shall terminate and be of no further force and

         effect upon the earliest to occur of (i) the Effective Time

         of the Merger and (ii) the termination of the Merger Agree-

         ment (A) in accordance with Sections 7.01(a), 7.01(b),

         7.01(d) or 7.01(e) of the Merger Agreement, (B) by MSI pursu-

         ant to Section 7.1(c) of the Merger Agreement if Cardinal's

         or Cardinal's affiliate's failure to perform any material

         covenant or obligation under the Merger Agreement has been

         the cause of or resulted in the failure of the Merger to oc-

         cur on or before February 15, 1996 which failure constitutes

         a breach, (C) by MSI pursuant to Section 7.1(k) of the Merger

         Agreement, or (D) pursuant to Section 7.1(c) or Section



                                      -2-<PAGE>







         7.1(g), in each case if no Prior Event (as defined below)

         shall have occurred prior thereto; provided, however, if (x)

         the Merger Agreement is terminated other than as provided in

         clause (ii) above, or (y) the termination of the Merger

         Agreement occurs after a Purchase Event, the Option shall not

         terminate until the date that is 12 months following such

         termination.  Notwithstanding the foregoing, if the Option

         cannot be exercised before its date of termination as a re-

         sult of any injunction, order or similar restraint issued by

         a court of competent jurisdiction, the Option shall expire on

         the 20th business day after such injunction, order or re-

         straint shall have been dissolved or when such injunction,

         order or restraint shall have become permanent and no longer

         subject to appeal, as the case may be.


                   (b)  As used herein, a "Purchase Event" shall mean

         any of the following events:


                   (i)  MSI or any of its subsidiaries shall or shall

              have entered into, authorized, recommended or publicly

              announced its intention to enter into an agreement, ar-

              rangement or understanding with any person (other than

              Cardinal or any of its affiliates) to, (A) effect any

              Competing Transaction, (B) sell, lease or otherwise dis-

              pose of 15% or more of the assets of MSI or any of its

              subsidiaries or (C) issue, sell or otherwise dispose of



                                      -3-<PAGE>







              (including by way of merger, consolidation, tender or

              exchange offer or similar transaction) Beneficial Owner-

              ship (as defined below) of securities representing 15%

              or more of the voting power of MSI or any of its subsid-

              iaries;


                  (ii)  any person (other than Cardinal or any affili-

              ate of Cardinal and other than as a result of execution

              of the Support Agreements) shall have acquired Benefi-

              cial Ownership or the right to acquire Beneficial Owner-

              ship of 15% or more of the voting power of MSI;  


                 (iii)  the Board of Directors of MSI shall have with-

              drawn or modified or changed its recommendation of the

              Merger Agreement or the Merger in a manner adverse to

              Cardinal, or shall have refused to affirm such recom-

              mendation within two days of any written request from

              Cardinal; or  


                  (iv)  the Merger Agreement shall have been termi-

              nated by MSI pursuant to Section 7.1(j).


                   (c)  As used herein, the terms "Beneficial Owner-

         ship", "Beneficial Owner" and "Beneficially Own" shall have

         the meanings ascribed to them in Rule 13d-3 under the Ex-

         change Act.  As used herein, a "Prior Event" shall be deemed

         to have occurred if: (x) any person (other than Cardinal or



                                      -4-<PAGE>







         any of its affiliates) shall have "commenced" (as such term

         is defined in Rule 14d-2 under the Exchange Act), or shall

         have filed a registration statement under the Securities Act

         with respect to, a tender offer or exchange offer to purchase

         shares of MSI Common Stock such that, upon consummation of

         such offer, such person would have Beneficial Ownership or

         the right to acquire Beneficial Ownership of 15% or more of

         the voting power of MSI or (y) any person (other than

         Cardinal or any of its affiliates) shall have publicly

         announced its willingness, or shall have publicly announced a

         proposal, or publicly disclosed an intention to make a pro-

         posal, (A) to make an offer described in clause (x) above or

         (B) to engage in any transaction described in clause (i) in

         the definition of Purchase Event.


                   (d)  In the event Cardinal wishes to exercise the

         Option, it shall deliver to MSI a written notice (the date of

         which being herein referred to as the "Notice Date") specify-

         ing (i) the total number of shares it intends to purchase

         pursuant to such exercise and (ii) a place and date not ear-

         lier than five business days nor later than 60 calendar days

         from the Notice Date for the closing of such purchase (the

         "Closing Date").



                                      -5-<PAGE>







                   (e)  Notwithstanding anything to the contrary in

         this Option Agreement, Cardinal shall have no right to exer-

         cise the Option while in material breach of the Merger Agree-

         ment.


                   4.  Payment and Delivery of Certificates.


                   (a)  At the closing, referred to in Section 3

         hereof, on the Closing Date, Cardinal shall (i) pay to MSI

         the aggregate Purchase Price for those shares of MSI Common

         Stock to be purchased as specified in the notice of exercise

         in immediately available funds by wire transfer to a bank ac-

         count designated not later than two business days prior to

         the Closing Date by MSI, and (ii) surrender this Option

         Agreement to MSI for cancellation.


                   (b)  At such closing, simultaneously with the de-

         livery of cash as provided in Section 4(a), MSI shall deliver

         to Cardinal (i) a certificate or certificates representing

         the number of shares of MSI Common Stock purchased by Cardi-

         nal, registered in the name of Cardinal or a nominee desig-

         nated in writing by Cardinal, and (ii) if the Option is exer-

         cised in part only, a newly executed agreement with the same

         terms as this Option Agreement evidencing the right to the

         balance of the MSI Common Stock purchasable hereunder.



                                      -6-<PAGE>







                   (c)  If at the time of issuance of any MSI Common

         Stock pursuant to any exercise of the Option, MSI shall have

         issued any share purchase rights or similar securities to

         holders of MSI Common Stock and such rights are then out-

         standing, then each such share of MSI Common Stock issued

         pursuant to such exercise shall also represent rights with

         terms substantially the same as and at least as favorable to

         Cardinal as those issued to other holders of MSI Common

         Stock.


                   (d)  Certificates for MSI Common Stock delivered at

         any closing hereunder shall be endorsed with a restrictive

         legend which shall read substantially as follows:


                   The shares represented by this certificate are sub-
                   ject to certain provisions of an agreement between
                   the registered holder hereof and Medicine Shoppe
                   International, Inc., a copy of which is on file at
                   the principal office of Medicine Shoppe Interna-
                   tional, Inc., and to resale restrictions arising
                   under the Securities Act of 1933 and any applicable
                   state securities laws.  A copy of such agreement
                   will be provided to the holder hereof without
                   charge upon receipt by Medicine Shoppe Interna-
                   tional, Inc. of a written request therefor.


         It is understood and agreed that the above legend shall be

         removed by delivery of substitute certificate(s) without such

         legend if Cardinal shall have delivered to MSI an opinion of

         outside counsel reasonably satisfactory to MSI in form and

         substance reasonably satisfactory to MSI to the effect that



                                      -7-<PAGE>







         such legend is not required for purposes of the Securities

         Act and any applicable state securities laws.


                   5.  Authorization, etc.


                   (a)  MSI hereby represents and warrants to Cardinal

         that: 


                   (i)  MSI has requisite corporate power and author-

              ity to execute and deliver this Option Agreement and to

              consummate the transactions contemplated hereby;


                  (ii)  such execution, delivery and consummation have

              been authorized by the Board of Directors of MSI, and no

              other corporate proceedings are necessary therefor; 


                  (ii)  this Option Agreement has been duly and val-

              idly executed and delivered and represents a valid and

              legally binding obligation of MSI, enforceable against

              MSI in accordance with its terms; and


                 (iii)  MSI has taken all necessary corporate action

              to authorize and reserve and permit it to issue and, at

              all times from the date hereof through the date of the

              exercise in full or the expiration or termination of the

              Option, shall have reserved for issuance upon exercise

              of the Option, 1,300,000 shares of MSI Common Stock, all

              of which, upon issuance pursuant hereto, shall be duly



                                      -8-<PAGE>







              authorized, validly issued, fully paid and nonassess-

              able, and shall be delivered free and clear of all

              claims, liens, encumbrances, restrictions and security

              interests and not subject to any preemptive rights.  


                   (b)  Cardinal hereby represents and warrants to MSI

         that:  


                   (i)  Cardinal has full corporate authority to ex-

              ecute and deliver this Option Agreement and to consum-

              mate the transactions contemplated hereby; 


                  (ii)  such execution, delivery and consummation have

              been authorized by all requisite corporate action by

              Cardinal, and no other corporate proceedings are neces-

              sary therefor; 


                 (iii)  this Option Agreement has been duly and val-

              idly executed and delivered and represents a valid and

              legally binding obligation of Cardinal, enforceable

              against Cardinal in accordance with its terms; and


                  (iv)  any MSI Common Stock or other securities ac-

              quired by Cardinal upon exercise of the Option will not

              be taken with a view to the public distribution thereof

              and will not be transferred or otherwise disposed of ex-

              cept in compliance with the Securities Act.



                                      -9-<PAGE>







                   6.  Adjustment upon Changes in Capitalization.


                   In the event of any change in MSI Common Stock by

         reason of stock dividends, split-ups, recapitalizations or

         the like, the type and number of shares subject to the Op-

         tion, and the purchase price per share, as the case may be,

         shall be adjusted appropriately.  In the event that any addi-

         tional shares of MSI Common Stock are issued after the date

         of this Option Agreement (other than pursuant to an event de-

         scribed in the preceding sentence or pursuant to this Option

         Agreement), the number of shares of MSI Common Stock subject

         to the Option shall be adjusted so that, after such issuance,

         it equals 14.38% of the number of shares of MSI Common Stock

         then issued and outstanding (including any shares subject to

         or issued pursuant to the Option).


                   7.  Repurchase at Option of MSI.


                   (a)  MSI may at any time by written notice repur-

         chase from Cardinal, and Cardinal shall sell to MSI, the Op-

         tion and all (but not less than all) of the MSI Common Stock

         acquired by Cardinal pursuant to the Option with respect to

         which Cardinal has Beneficial Ownership at the time of such

         repurchase at an aggregate purchase price equal to the sum of

         (i) the difference between $47.8458 and the exercise price as

         determined pursuant to Section 2 hereof (subject to adjust-

         ment as provided in Section 6), multiplied by the number of



                                      -10-<PAGE>







         shares of MSI Common Stock with respect to which the Option

         has not been exercised, and (ii) $47.8458 multiplied by the

         number of shares of MSI Common Stock purchased pursuant to

         the exercise of the Option with respect to which Cardinal

         then has Beneficial Ownership.


                   (b)  In the event that MSI wishes to exercise its

         rights under this Section 7, MSI shall deliver to Cardinal a

         written notice (the date of which being herein referred to as

         the "Call Date") specifying a place and date not earlier than

         three business days nor more than 60 calendar days from the

         Call Date for the closing of such repurchase.  At the clos-

         ing, MSI shall pay the purchase price to Cardinal by wire

         transfer of immediately available funds to an account desig-

         nated by Cardinal not later than two business days prior to

         the date of closing and Cardinal shall surrender to MSI the

         Option and the certificates evidencing any and all shares of

         MSI Common Stock purchased thereunder with respect to which

         Cardinal then has Beneficial Ownership together with any and

         all other instruments which MSI's transfer agent may require

         to properly transfer ownership thereof to MSI.


                   8.  Registration Rights.


                   At any time after a Purchase Event, MSI shall, if

         requested by holders or Beneficial Owners of not less than

         250,000 shares of MSI Common Stock issued upon exercise of



                                      -11-<PAGE>







         the Option (each a "Holder"), as expeditiously as possible

         file a registration statement on an appropriate form under

         the Securities Act if necessary in order to permit the sale

         or other disposition of the shares of MSI Common Stock that

         have been acquired upon exercise of the Option in accordance

         with the intended method of sale or other disposition re-

         quested by any such Holder.  Each Holder shall provide all

         information reasonably requested by MSI for inclusion in any

         registration statement to be filed hereunder and shall pro-

         vide MSI, any person controlling MSI, any underwriter and

         each other Holder with customary representations, warranties,

         covenants, indemnification and contribution in connection

         with such registration.  MSI shall use its best efforts to

         cause such registration statement first to become effective

         and then to remain effective for such period not in excess of

         180 days from the day such registration statement first be-

         comes effective as may be reasonably necessary to effect such

         sales or other dispositions.  The registration effected under

         this Section 8 shall be at MSI's expense except for under-

         writing commissions and the fees and disbursements of such

         Holders' counsel attributable to the registration of such MSI

         Common Stock.  In no event shall MSI be required to effect

         more than two registrations hereunder.  The filing of any

         registration statement required hereunder may be delayed for

         such period of time (not to exceed 60 days) as may reasonably



                                      -12-<PAGE>







         be required to facilitate any public distribution by MSI of

         MSI Common Stock or if a special audit of MSI would otherwise

         be required in connection therewith.  If requested by any

         such Holder in connection with such registration, MSI shall

         become a party to any underwriting agreement relating to the

         sale of such shares on terms and including obligations and

         indemnities which are customary for parties similarly situ-

         ated.  Upon receiving any request for registration under this

         Section 8 from any Holder, MSI agrees to send a copy thereof

         to any other person known to MSI to be entitled to registra-

         tion rights under this Section 8, in each case by promptly

         mailing the same, postage prepaid, to the address of record

         of the persons entitled to receive such copies.


                   9.  Severability.


                   Any term, provision, covenant or restriction con-

         tained in this Option Agreement held by a court or other Gov-

         ernmental Authority of competent jurisdiction to be invalid,

         void or unenforceable, shall be ineffective to the extent of

         such invalidity, voidness or unenforceability, but neither

         the remaining terms, provisions, covenants or restrictions

         contained in this Option Agreement nor the validity or en-

         forceability thereof in any other jurisdiction shall be af-

         fected or impaired thereby.  Any term, provision, covenant or

         restriction contained in this Option Agreement that is so



                                      -13-<PAGE>







         found to be so broad as to be unenforceable shall be inter-

         preted to be as broad as is enforceable.  


                   10.  Miscellaneous.


                   (a)  Expenses.  Each of the parties hereto shall

         pay all costs and expenses incurred by it or on its behalf in

         connection with the transactions contemplated hereunder, in-

         cluding fees and expenses of its own financial consultants,

         investment bankers, accountants and counsel, except as other-

         wise provided herein.


                   (b)  Entire Agreement.  This Agreement, the Support

         Agreements, the Merger Agreement (including the documents and

         the instruments referred to therein) and the Confidentiality

         Agreement constitute the entire agreement among the parties

         and supersede all prior agreements and understandings, agree-

         ments or representations by or among the parties, written and

         oral, with respect to the subject matter hereof and thereof.


                   (c)  Successors; No Third Party Beneficiaries.  The

         terms and conditions of this Option Agreement shall inure to

         the benefit of and be binding upon the parties hereto and

         their respective successors and permitted assigns.  Nothing

         in this Option Agreement, expressed or implied, is intended

         to confer upon any party, other than the parties hereto, and



                                      -14-<PAGE>







         their respective successors and assigns, any rights, reme-

         dies, obligations, or liabilities under or by reason of this

         Option Agreement, except as expressly provided herein.


                   (d)  Notices.  All notices or other communications

         which are required or permitted hereunder shall be in writing

         and sufficient if delivered in accordance with Section 8.2 of

         the Merger Agreement (which is incorporated herein by ref-

         erence).


                   (e)  Counterparts.  This Option Agreement may be

         executed in counterparts, and each such counterpart shall be

         deemed to be an original instrument, but both such counter-

         parts together shall constitute but one agreement.


                   (f)  Specific Performance.  The parties hereto

         agree that if for any reason Cardinal or MSI shall have

         failed to perform its obligations under this Option Agree-

         ment, then either party hereto seeking to enforce this Option

         Agreement against such non-performing party shall be entitled

         to specific performance and injunctive and other equitable

         relief, and the parties hereto further agree to waive any re-

         quirement for the securing or posting of any bond in connec-

         tion with the obtaining of any such injunctive or other equi-

         table relief.  This provision is without prejudice to any

         other rights that either party hereto may have against the



                                      -15-<PAGE>







         other party hereto for any failure to perform its obligations

         under this Option Agreement.


                   (g)  Governing Law.  This Option Agreement shall be

         governed by and construed in accordance with the laws of the

         State of Delaware applicable to agreements made and entirely

         to be performed within such state.  Nothing in this Option

         Agreement shall be construed to require any party (or any

         subsidiary or affiliate of any party) to take any action or

         fail to take any action in violation of applicable law, rule

         or regulation.


                   (h)  Regulatory Approvals; Section 16(b).  If, in

         connection with the exercise of the Option under Section 3,

         prior notification to or approval of any Governmental Author-

         ity is required, then the required notice or application for

         approval shall be promptly filed and/or expeditiously pro-

         cessed by MSI and periods of time that otherwise would run

         pursuant hereto (if any) shall run instead from the date on

         which any such required notification period has expired or

         been terminated or such approval has been obtained, and in

         either event, any requisite waiting period shall have passed.

         Periods of time that otherwise would run pursuant to Sections

         3, 7 or 8 shall also be extended to the extent necessary to

         avoid liability under Section 16(b) of the Exchange Act.



                                      -16-<PAGE>







                   (i)  Waiver and Amendment.  Any provision of this

         Agreement may be waived at any time by the party that is en-

         titled to the benefits of such provision.  This Option Agree-

         ment may not be modified, amended, altered or supplemented

         except upon the execution and delivery of a written agreement

         executed by the parties hereto.





































                                      -17-<PAGE>









                   IN WITNESS WHEREOF, each of the parties hereto has

         executed this Option Agreement as of the date first written

         above.


                                       CARDINAL HEALTH, INC.



                                       By: /s/  Robert D. Walter     
                                          Name: Robert D. Walter                
                                          Title: Chairman and Chief            
                                                   Executive Officer


                                       MEDICINE SHOPPE INTERNATIONAL, INC.



                                       By: /s/  David A. Abrahamson  
                                          Name: David A. Abrahamson
                                          Title: Chief Executive Officer      























                                          -18-





                       [Form of Support/Voting Agreement] 




                                       August 26, 1995


         Cardinal Health, Inc.
         655 Metro Place South
         Suite 925
         Dublin, Ohio  43017

                   Re:  Support/Voting Agreement

         Dear Sirs:  

                   The undersigned understands that Cardinal Health,
         Inc. ("Cardinal"), Arch Merger Corp., a wholly owned subsid-
         iary of Cardinal ("Subcorp"), and Medicine Shoppe Interna-
         tional, Inc. ("MSI") are entering into an Agreement and Plan
         of Merger dated the date hereof (the "Agreement") providing
         for, among other things, a merger between Subcorp and MSI
         (the "Merger"), in which all of the outstanding shares of
         capital stock of MSI will be exchanged for shares of common
         stock, without par value, of Cardinal.

                   The undersigned is a stockholder of MSI (the
         "Stockholder") and is entering into this letter agreement to
         induce you to enter into the Agreement and to consummate the
         transactions contemplated thereby.

                   The Stockholder confirms its agreement with you as
         follows:

                   1.  The Stockholder represents, warrants and agrees
         that Schedule I annexed hereto sets forth the shares of the
         capital stock of MSI of which the Stockholder is the record
         or beneficial owner (the "Shares") and that the Stockholder
         is on the date hereof the lawful owner of the number of
         Shares set forth in Schedule I, free and clear of all liens,
         charges, encumbrances, voting agreements and commitments of
         every kind, except as disclosed in Schedule I.  Except as set
         forth in Schedule I, the Stockholder does not own or hold any
         rights to acquire any additional shares of the capital stock
         of MSI (by exercise of stock options or otherwise) or any in-
         terest therein or any voting rights with respect to any ad-
         ditional shares.  

                   2.  The Stockholder agrees that it will not, and
         will not permit any company, trust or other entity controlled
         by the Stockholder to, contract to sell, sell or otherwise
         transfer or dispose of any of the Shares or any interest<PAGE>








         therein or securities convertible thereinto or any voting
         rights with respect thereto, other than (i) pursuant to the
         Merger or (ii) with your prior written consent.

                   3.  The Stockholder agrees to, and will cause any
         company, trust or other entity controlled by the Stockholder
         to, cooperate fully with you in connection with the Agreement
         and the transactions contemplated thereby.  The Stockholder
         agrees that it will not, and will not permit any such com-
         pany, trust or other entity to, directly or indirectly (in-
         cluding through its officers, directors, employees or other
         representatives) solicit, initiate, encourage or facilitate,
         or furnish or disclose non-public information in furtherance
         of, any inquiries or the making of any proposal with respect
         to any recapitalization, merger, consolidation or other busi-
         ness combination involving MSI, or acquisition of any capital
         stock or any material portion of the assets (except for ac-
         quisitions of assets in the ordinary course of business con-
         sistent with past practice) of MSI, or any combination of the
         foregoing (a "Competing Transaction"), or negotiate, explore
         or otherwise engage in discussions with any person (other
         than Cardinal, Subcorp or their respective directors, offic-
         ers, employees, agents and representatives) with respect to
         any Competing Transaction or enter into any agreement, ar-
         rangement or understanding with respect to any Competing
         Transaction or agree to or otherwise assist in the effectua-
         tion of any Competing Transaction; provided, however, that
         nothing herein shall prevent the Stockholder from taking any
         action or omitting to take any action as a member of the
         Board of Directors of MSI to the extent permitted by Section
         5.3(d) of the Agreement.

                   4.  The Stockholder agrees that all of the Shares
         beneficially owned by the Stockholder, or over which the
         Stockholder has voting power or control, directly or indi-
         rectly (including any common shares of MSI acquired after the
         date hereof), at the record date for any meeting of stock-
         holders of MSI called to consider and vote to approve the
         Merger and the Agreement and/or the transactions contemplated
         thereby will be voted by the Stockholder in favor thereof and
         that Stockholder will not vote such Shares in favor of any
         Competing Transaction.

                   5.   The Stockholder has all necessary power and
         authority to enter into this letter agreement.  This agree-
         ment is the legal, valid and binding agreement of the Stock-
         holder, and is enforceable against the Stockholder in ac-
         cordance with its terms.


                                      -2-<PAGE>








                   6.   The Stockholder agrees that damages are an in-
         adequate remedy for the breach by Stockholder of any term or
         condition of this letter agreement and that you shall be en-
         titled to a temporary restraining order and preliminary and
         permanent injunctive relief in order to enforce our agree-
         ments herein.  

                   This letter agreement may be terminated at the op-
         tion of any party at any time after the earlier of (i) ter-
         mination of the Agreement and (ii) the Effective Time (as de-
         fined in the Agreement).  Please confirm that the foregoing
         correctly states the understanding between us by signing and
         returning to me a counterpart hereof.

                                       Very truly yours,



                                       By:  _______________________
                                            Stockholder
         Confirmed on the date
         first above written.

         Cardinal Health, Inc.



         By:  ___________________________




















                                      -3-<PAGE>





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