IMMUNOMEDICS INC
S-3, 2000-01-11
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                           Registration No. 333-_____

    As filed with the Securities and Exchange Commission on January 11, 2000

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                    FORM S-3

             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
                               IMMUNOMEDICS, INC.
             (Exact name of registrant as specified in its charter)

                         Delaware                     61-1009366
             (State or other jurisdiction of       (I.R.S. Employer
              incorporation or organization)        Identification No.)

                                300 American Road
                         Morris Plains, New Jersey 07950
                                 (973) 605-8200
                   (Address, including zip code, and telephone
                         number, including area code, of
                        registrant's principal executive
                                    offices)
                             Dr. David M. Goldenberg
                      Chairman and Chief Executive Officer
                               Immunomedics, Inc.
                                300 American Road
                         Morris Plains, New Jersey 07950
                                 (973) 605-8200
 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)
                          Copies of all communications,
                          including all communications
                              sent to the agent for
                           service, should be sent to:
                            Peter H. Ehrenberg, Esq.
                              Lowenstein Sandler PC
                              65 Livingston Avenue
                           Roseland, New Jersey 10024
                                 (973) 597-2500

Approximate  date of commencement  of proposed sale to the public:  From time to
time after the effective date of this Registration Statement.

If the only securities  being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box: [ ]

If any of the  securities  being  registered on this Form are to be offered on a
delayed or continuous  basis  pursuant to Rule 415 under the  Securities  Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box: [x]

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the  Securities  Act  registration  statement  number of the  earlier  effective
registration statement for the same offering. [ ]

If this Form is a  post-effective  amendment filed pursuant to Rule 462(c) under
the  Securities  Act,  check  the  following  box and  list the  Securities  Act
registration  statement number of the earlier effective  registration  statement
for the same offering. [ ]

If delivery  of the  prospectus  is  expected  to be made  pursuant to Rule 434,
please check the following box: [ ]

<TABLE>
<CAPTION>

                         CALCULATION OF REGISTRATION FEE
                         -------------------------------

Title of Each Class of          Amount of Shares to be     Proposed Maximum         Proposed Maximum              Amount of
Securities to be Registered          Registered (1)(2)    Offering Price Per            Aggregate            Registration Fee
                                                              Share(3)              Offering Price(3)
- ---------------------------     ----------------------    ------------------        -----------------        ----------------
<C>                             <S>                       <S>                       <S>                      <S>
Common Stock, $.01 par
value per share                      2,575,000              $   12.25                $ 31,543,750                $ 8,328

</TABLE>

(1) Consists of (a)  2,500,000  shares of common stock  available  for resale by
purchasers  under a Common Stock  Purchase  Agreement,  dated as of December 14,
1999, by and among the Registrant and such purchasers (the "Purchase Agreement")
and (b) 75,000  shares of common stock  issuable  upon the exercise of a warrant
granted by the registrant (the "Warrant").

(2)  Plus an  indeterminate  number  of  shares  of  common  stock  issuable  in
connection with the anti-dilutions  provisions of the Purchase Agreement and the
Warrant.

(3) Pursuant to Rule 457(c),  the proposed  maximum offering price per share and
proposed maximum  aggregate  offering price have been calculated on the basis of
the average of the high and low sale prices of the registrant's  common stock as
reported on The Nasdaq National Market on January 7, 2000.

<PAGE>

The Registrant hereby amends this  Registration  Statement on such date or dates
as may be necessary to delay its effective date until the Registrant  shall file
a further amendment which specifically  states that this Registration  Statement
shall  thereafter  become  effective  in  accordance  with  Section  8(a) of the
Securities  Act of  1933  or  until  the  Registration  Statement  shall  become
effective on such date as the  Commission,  acting pursuant to Section 8(a), may
determine.

                                      -2-

<PAGE>


The  information in this Prospectus is subject to completion and may be changed.
The selling  stockholders  may not sell these  securities until the registration
statement  filed with the  Securities  and  Exchange  Commission  (of which this
Prospectus  is a part) is  effective.  This  Prospectus  is not an offer to sell
these securities, and is not soliciting an offer to buy these securities, in any
state where such offer or sale is not permitted

PROSPECTUS

                               IMMUNOMEDICS, INC.

                        2,575,000 Shares of Common Stock

The Issuer

Immunomedics. Inc.
300 American Road
Morris Plains, New Jersey 07950
(973) 605-8200

The Selling Stockholders

         One selling  stockholder  is  offering to sell 75,000  shares of common
stock that it may  acquire  upon  exercise  of a warrant  that we issued to that
stockholder  in its  capacity  as  our  financial  advisor.  The  other  selling
stockholders  are  offering  to sell  2,500,000  shares of common  stock that we
issued  to them on  December  14,  1999  pursuant  to a  Common  Stock  Purchase
Agreement.  Additional  information  concerning our agreements  with the selling
stockholders  is set  forth  under the  captions  "Immunomedics  Agreement  with
Financial Advisor" and "Immunomedics - December 1999 Financing."

Trading Symbol

         Nasdaq National Market -  "IMMU"

         The  closing  sale  price of a share of our  common  stock on Nasdaq on
_________, 2000 was $_____.

The Offering

         The selling  stockholders may sell shares of our common stock from time
to time on the  Nasdaq  National  Market at the  prevailing  market  price or in
private,  negotiated transactions.  The shares will be sold at prices determined
by the selling  stockholders.  We will not receive any part of the proceeds from
the sale. We are paying the expenses in connection with the  registration of the
shares with the SEC. The selling stockholders may be deemed to be "underwriters"
within the meaning of the Securities  Act in connection  with the sale of shares
of our common stock.

         A  purchase  of  shares  involves  a high  degree of risk.  You  should
purchase shares only if you can afford a complete loss of your  investment.  See
"Risk Factors" beginning on page 3.

Neither  the  Securities  and  Exchange  Commission  nor  any  state  securities
commission  has approved or disapproved  these  securities or determined if this
prospectus  is truthful or  complete.  Any  representation  to the contrary is a
criminal offense.

                                                            _________, 2000


<PAGE>


                                TABLE OF CONTENTS

Risk Factors:
           We Have a History of Operating Losses and May Never Become
              Profitable....................................................   4
           We May Not Be Able to Successfully Develop a Market for Our Approved
              Products......................................................   4
           We May Not Receive Approval to Sell LeukoScan in the United States
              in a Timely Manner............................................   4
           We May Not Be Able to Bring to Market the Products We Are Currently
              Developing or Sustain Their Sales After Approval..............   4
           If We Do Not Obtain Additional Capital, We May Be Required to Curtail
              Our Operations................................................   5
           Our Limited Marketing and Sales Experience and Capability Could
              Impact Our Ability to Successfully Sell Our Current Products..   5
           We May Have to Rely on Partners to Help Us Market and Sell Our
              Products Under Development....................................   5
           We Could Be Temporarily Unable to Sell Our Products If Our Agreements
              with our Distributors Were Terminated.........................   5
           We Could Be Temporarily Unable to Sell Our Products If Our Agreement
              with our End Stage Manufacturer Was Terminated................   6
           Our Internal Manufacturing Capability May Limit What We Can Sell.   6
           We May Be Unable to Continue to Use Mouse Fluids for Future Products
              Which Could Require Us to Make Expensive and Time Consuming
              Changes to Our Products in Development........................   6
           Our Product Development Is Dependent Upon Our Continued Relationship
              with The Center for Molecular Medicine and Immunology.........   6
           Certain Potential Conflicts of Interest Exist with The Center for
              Molecular Medicine and Immunology Which Could Affect Our
              Operations....................................................   6
           We May Not Be Able to Obtain Government Regulatory Approval in a
              Timely Manner to Market and Sell Our Products or Approval May Be
              Withdrawn.....................................................   7
           Our Business Involves the Use of Hazardous Materials.............   7
           We Must Maintain Our Manufacturing Facilities in Accordance With
              Government Regulatory Requirements............................   7
           We Have Agreed to Certain Covenants in our 1999 Financing Which Place
              Restrictions on the Operation of our Business.................   7
           Changes to Health Care Reimbursement Could Adversely Affect Our
              Operations....................................................   8
           The Loss of Key Employees Could Adversely Affect our Operations..   8
           We Face Substantial Competition in the Biotechnology Field and
              May Not Be Able to Successfully Compete.......................   8
           Our Products May Be Rendered Obsolete By Rapid Technological
              Change........................................................   8
           If We Are Unable to Protect Our Intellectual Property Rights, We
              Could Lose Our Competitive Advantage..........................   9
           Our Products May Infringe Third Party Intellectual Property
              Rights........................................................   9
           Our Operations Could Suffer If We Are Unsuccessful in Our Pending
              Infringement Claims Concerning Our CEA Antibodies.............   9
           Product Liability Claims in Excess of the Amount of Our Insurance
              Would Adversely Affect Our Financial Condition................   9
           Our Principal Stockholder Can Influence Most Matters Requiring
              Approval By Our Stockholders..................................  10
           Resales of Shares Held By Our Directors and Executive Officers May
              Lower the Market Price of Our Common Stock....................  10
           Our Stock Price Has Been Volatile................................  10
           Potential Loss of Our Nasdaq Listing Could Make it More Difficult to
              Sell our Shares and Affect Our Liquidity......................  10

                                      -2-

<PAGE>
           Stockholders Could Be Adversely Affected By Our Anti-Takeover
              Provisions....................................................  10
           Our Operations Could Be Affected By Year 2000 Issues.............  11
           Stockholders Should Not Expect that We Will Pay Dividends........  11
           Special Note Regarding Forward-Looking Statements................  11

Where You Can Find More Information.........................................  12

Immunomedics:
           Description of Our Business......................................  13
           December 1999 Financing..........................................  15
           Agreement with Financial Advisor.................................  16

Use of Proceeds.............................................................  16

Selling Stockholders........................................................  17

Plan of Distribution:
           Manner of Sales; Broker-Dealer Compensation......................  18
           Filing of a Post-Effective Amendment In Certain Instances........  19
           Certain Persons May Be Deemed to Be Underwriters.................  19
           Regulation M.....................................................  20
           Indemnification and Other Matters................................  20

Legal Matters...............................................................  20

Experts.....................................................................  20

         You  should  rely  on the  information  incorporated  by  reference  or
provided in this prospectus or any supplement.  We have not authorized anyone to
provide  you  with  different  information.  You  should  not  assume  that  the
information  in this  prospectus  or any  supplement  is accurate as of any date
other than the date on the front of such document.  The selling stockholders are
not making an offer of our shares in any state where the offer is not permitted.

                                      -3-

<PAGE>

                                  RISK FACTORS

         Investing  in our common  stock  involves a high  degree of risk.  As a
result,  you should be able to sustain a complete  loss of your  investment.  In
addition  to the other  information  in this  prospectus,  you should  carefully
consider the following factors before purchasing any of our common stock.

We Have a History of Operating Losses and May Never Become Profitable

         We have had  significant  operating  losses since our formation in 1982
and have not earned a profit since our  inception.  These  operating  losses and
failure to be profitable have been due mainly to the significant amount of money
that we have had to spend on research and development. As of September 30, 1999,
we had an  accumulated  deficit  of  approximately  $101,600,000.  We  expect to
continue to experience  operating losses until such time, if at all, that we are
able to generate  sufficient  revenues from sales of  CEA-Scan(r),  LeukoScan(r)
and/or our other potential products.

We May Not Be Able to Successfully Develop a Market for Our Approved Products

         CEA-Scan and LeukoScan  are the only products  which we are licensed to
market and sell. To date,  we have received only limited  revenues from the sale
of these  products.  We cannot  assure  you that  these  products  or any of our
proposed products will achieve market acceptance or generate significant sales.

We May Not Receive Approval to Sell LeukoScan in the United States in a Timely
Manner

         We have  not yet  received  approval  from the FDA to  market  and sell
LeukoScan in the United States and cannot  assure you as to when, if ever,  that
we will obtain  approval.  In addition,  the FDA could impose  conditions on its
approval,  which could  significantly  affect the  commercial  viability  of the
product  or could  require us to  undertake  significant  additional  studies or
otherwise expend additional  significant funds. If we do not receive approval to
market and sell  LeukoScan in the United States in the near future or if the FDA
imposes  significant  conditions or  restrictions,  our business and  operations
could be significantly and adversely affected.

We May Not Be Able to Bring to Market the Products We Are Currently Developing
or Sustain Their Sales After Approval

         Before any of our  products  that we are  currently  developing  can be
marketed and sold, we must undertake  substantial research and development.  All
new products face a high degree of uncertainty, including the following:

*    We may not receive regulatory approval to perform human clinical trials for
     the products we currently have planned or we may be unable to  successfully
     complete our ongoing clinical trials.

*    The  results  from  preclinical  studies  and  clinical  trials  may not be
     indicative of results that will be obtained in later-stage testing.

*    We may be unable to timely recruit a sufficient  number of patients for our
     clinical  trials.  Delays  in  planned  patient  enrollment  may  result in
     increased costs and delays.

*    We may be unable to obtain  approval  from the FDA and  comparable  foreign
     authorities  because we are unable to demonstrate  that the product is safe
     and effective for the intended  use, or obtaining  regulatory  approval may
     take  significantly  more time and cost  significantly  more  money than we
     currently anticipate.

                                      -4-

<PAGE>

*    We may discover that the product has undesirable or unintended side effects
     or other characteristics that make it impossible or impracticable for us to
     continue development or which may limit the product's commercial use.

*    We do not expect that any new product  which is  currently  in research and
     development will be commercially available for at least several years.

*    We may be unable  to  produce  the  product  in  commercial  quantities  at
     reasonable cost.

*    We may  be  unable  to  successfully  market  the  product  or to  find  an
     appropriate corporate partner, if necessary,  to assist us in the marketing
     of the product.

*    The product may not gain satisfactory market acceptance.

*    The product may be superceded  by another  product  commercialized  for the
     same  indication  or may  infringe  patents  issued to others,  which would
     prevent us from marketing and selling the product.

*    After  approval,  the product may be recalled or withdrawn at any time as a
     result  of  regulatory  issues,   including  those  concerning  safety  and
     efficacy.

If we are  unable to  continue  to  develop  products  that we can  successfully
market,  our business,  financial  condition  and results of operations  will be
significantly and adversely affected.

If We Do Not Obtain Additional Capital, We May Be Required to Curtail Our
Operations

         Without a significant increase in product revenues or other infusion of
capital  during our  current  fiscal year which ends June 30,  2000,  we will be
required to significantly reduce our operating expenses, including the amount of
resources  devoted to  marketing  and sales,  product  development  and clinical
trials,  which  could have a  significant  and  adverse  effect on us. We cannot
assure you that any  additional  financing  will be available to us at all or on
terms we find  acceptable  or that the  terms of any  financing  will not  cause
substantial dilution to our existing stockholders.

Our Limited Marketing and Sales Experience and Capability Could Impact Our
Ability to Successfully Sell Our Current Products

         We are  relying,  in  substantial  part,  on our own limited  sales and
marketing  organization to market CEA- Scan and LeukoScan.  We cannot assure you
that we can  successfully  maintain and continue to build our sales force. If we
are unable to continue to build and  maintain  our sales  force,  our  financial
condition and operating results may be significantly and adversely affected.

We May Have to Rely on Partners to Help Us Market and Sell Our Products Under
Development

         The marketing and sale of our proposed  products may be dependent  upon
our entering into  arrangements  with corporate  partners.  We cannot assure you
that we  will  be  successful  in  forming  these  relationships  or that  these
relationships, even if formed, will be successful.

We Could Be Temporarily Unable to Sell Our Products If Our Agreements with our
Distributors Were Terminated

         We  currently  do not have the  resources  to  internally  develop  and
maintain the operating  procedures  required by the FDA and  comparable  foreign
regulatory  authorities to oversee distribution of our products. As a result, we
have entered into  arrangements  with third parties to perform this function for
the foreseeable future. If these agreements are terminated,  we will be required
to enter into arrangements with other government approved third parties in order
to be  able to  distribute  our  products.

                                      -5-
<PAGE>

We will be unable to continue to  distribute  our products  until an  acceptable
alternative is identified. If we were even only temporarily unable to distribute
our products, our business could be significantly and adversely effected.

We Could Be Temporarily Unable to Sell Our Products If Our Agreement with our
End Stage Manufacturer Was Terminated

         We rely on a single third party to perform certain  end-stage  portions
of the  manufacturing  process for CEA-Scan and LeukoScan which we are unable or
do not have the  resources  to  perform.  If this  third  party  were to  become
unavailable,  we would be unable to complete the manufacturing  process until we
entered into an agreement with another  qualified  entity.  We cannot assure you
that we will be able to negotiate an agreement  with another  entity on terms we
consider  acceptable,  if at all. Even if we were able to do so, any substantial
delay in our  ability  to  manufacture  our  products  could  significantly  and
adversely affect our operations.

Our Internal Manufacturing Capability May Limit What We Can Sell

         If demand for our approved product increases  significantly,  we cannot
assure you that we will continue to have the capacity to manufacture  commercial
quantities successfully.  In addition, if any of our other products are approved
for  marketing  and sale, we cannot assure you that we will continue to have the
capacity and expertise to manufacture commercial quantities of multiple products
successfully or with acceptable profit margins. If we were even only temporarily
unable to manufacture  sufficient quantities of our products to meet demand, our
business could be significantly and adversely effected.

We May Be Unable to Continue to Use Mouse Fluids for Future Products Which Could
Require Us to Make Expensive and Time Consuming Changes to Our Products in
Development

         CEA-Scan  and  certain of our other  imaging  agents are  derived  from
ascites fluid produced in mice. Regulatory authorities,  particularly in Europe,
have  expressed  concerns  about  the use of mice  fluid for the  production  of
monoclonal  antibodies.  We cannot assure you that regulatory  authorities  will
agree that our quality control  procedures will be adequate for future products.
While we are  continuing  our  development  efforts  to  produce  certain of our
monoclonal  antibodies  using cell culture methods,  this process  constitutes a
substantial  production  change,  which will  require  additional  manufacturing
equipment and new  regulatory  approval.  We cannot assure you that we will have
the resources to acquire the additional manufacturing equipment and resources or
that we will receive the required  regulatory  approval on a timely basis, if at
all.  We also  have  contracted  with a third  party  for  the  development  and
production of certain humanized antibodies,  but we cannot assure you that these
efforts will be successful.

Our Product Development Is Dependent Upon Our Continued Relationship with The
Center for Molecular Medicine and Immunology

         The Center for  Molecular  Medicine and  Immunology,  a  not-for-profit
cancer research center,  performs pilot and pre-clinical trials in product areas
of importance to us. CMMI also conducts basic  research and patient  evaluations
in a number  of areas of  potential  interest  to us.  If CMMI were no longer to
provide these  services,  we would have to make  alternative  arrangements  with
third parties which could  significantly  delay and increase expenses associated
with pre-clinical testing and initial clinical trials.

Certain Potential Conflicts of Interest Exist with The Center for Molecular
Medicine and Immunology Which Could Affect Our Operations

         Dr. David M. Goldenberg,  our Chairman and Chief Executive Officer,  is
the  founder,  President  and a member of the  Board of  Trustees  of CMMI.  Dr.
Goldenberg  devotes  more of his time working for CMMI than for us.

                                      -6-
<PAGE>

In addition,  other key personnel currently have  responsibilities  both to CMMI
and us. As a result,  the potential for conflict of interest exists and disputes
could  arise  over  the  allocation  of  research   projects  and  ownership  of
intellectual property rights.

We May Not Be Able to Obtain Government Regulatory Approval in a Timely Manner
to Market and Sell Our Products or Approval May Be Withdrawn

         Regulation by governmental authorities in the United States and foreign
countries  is a  significant  factor in the  manufacture  and  marketing  of our
presently marketed and proposed products as well as our research and development
activities.  All of our proposed  products will require  regulatory  approval by
governmental  agencies prior to commercialization  and our products must undergo
rigorous   preclinical  and  clinical  testing  and  other  premarket   approval
procedures by the FDA and comparable  foreign  authorities.  In addition,  since
certain of our potential  products involve the application of new  technologies,
regulatory  approvals  may take longer  than for  products  produced  using more
conventional  methods.  Once we begin  clinical  trials for a new  diagnostic or
therapeutic  product,  it may  take  five to ten  years or more to  receive  the
required  regulatory  approval to commercialize that product and begin to market
it to the  public.  Various  federal  and,  in some cases,  state  statutes  and
regulations  also  govern or  influence  the  manufacturing,  safety,  labeling,
storage,  record keeping and marketing of these products. The lengthy process of
seeking these approvals,  and the subsequent compliance with applicable statutes
and regulations,  will require us to expend substantial resources. If we fail to
obtain or are otherwise substantially delayed in obtaining regulatory approvals,
our business and operations could be significantly and adversely affected.

         In  responding  to  a  new  drug  application,  or a  biologic  license
application,  government  regulators  may  grant  marketing  approvals,  request
additional  information  or  further  research,  or deny the  application  if it
determines  that  the  application  does not  satisfy  its  regulatory  approval
criteria.  Approvals  may not be granted  on a timely  basis,  if at all,  or if
granted  may not cover all the  clinical  indications  for which we are  seeking
approval  or may  contain  significant  limitations  in the  form  of  warnings,
precautions or  contraindications  with respect to conditions of use. Even after
approval,  we may be  required  to recall or  withdraw  a product as a result of
subsequently discovered safety or efficacy concerns.

Our Business Involves the Use of Hazardous Materials

         In  addition to laws and  regulations  enforced by the FDA, we are also
subject to regulation under various other foreign,  federal, state or local laws
and  regulations.  Our research and  development  involves the controlled use of
hazardous materials,  chemicals,  viruses and various radioactive compounds. The
risk of  accidental  contamination  or injury  from  these  materials  cannot be
completely  eliminated.  If an accident occurs,  we could be held liable for any
damages that result and any liability could exceed our resources.

We Must Maintain Our Manufacturing Facilities in Accordance With Government
Regulatory Requirements

         Our  facilities  are subject to  inspection  by the FDA and  comparable
foreign  authorities.  A separate  license is sometimes  required for commercial
manufacture  of any product.  Failure to maintain  these licenses or to meet the
regulatory  inspection  criteria would result in disruption to our manufacturing
processes  and could have a significant  and adverse  effect on our business and
operations.

We Have Agreed to Certain Covenants in our 1999 Financing Which Place
Restrictions on the Operation of our Business

         In  connection  with our  December  1999  financing,  we have agreed to
certain  covenants,  including  covenants that will apply until such time as the
investors in that offering and their affiliates beneficially own less than 5% of
our common  stock.  Among other  things,  we have agreed that  without the prior
consent of the  investors,  we may not sell our  business  to anyone  that is an
affiliate of the company, unless the sale is for consideration at least equal to
(a) the fair  market  value in the event of a sale of

                                      -7-
<PAGE>

assets (as  determined  in good faith by our board of directors) or (b) the then
current  market price in the event of a sale of stock.  As of December 30, 1999,
such  investors  in the  aggregate  beneficially  owned 6.2% of our  outstanding
common stock. For additional  information regarding our December 1999 financing,
see "Immunomedics - December 1999 Financing."

Changes to Health Care Reimbursement Could Adversely Affect Our Operations

         Our ability to successfully  commercialize  our products will depend in
part on the  extent  to which  reimbursement  for the cost of our  products  and
related  treatment  will be  available  from  government  health  administration
authorities, private health insurers and other organizations.  These third-party
payers are increasingly  challenging the price of medical products and services.
Several proposals have been made that may lead to a government-directed national
health  care  system.  Adoption  of this  type of  system  could  further  limit
reimbursement  for  medical  products,  and we cannot  assure you that  adequate
third-party  coverage  will be available  to enable us to maintain  price levels
sufficient  to  realize  an  appropriate  return on our  investment  in  product
development.  In addition, we also cannot assure you that the U.S. government or
foreign  governments  will not implement a system of price controls.  Any system
might  significantly  and  adversely  affect our ability to market our  products
profitably.

The Loss of Key Employees Could Adversely Affect our Operations

         As a small  biotechnology  company,  we are heavily  dependent upon the
talents  of  Dr.  Goldenberg  and  certain  key  scientific  personnel.  If  Dr.
Goldenberg or any of our other key personnel  leave our employ,  our  operations
could be significantly and adversely affected. In addition, from time to time we
have a need to expand our management and scientific  personnel.  Competition for
qualified  personnel  in the  biotechnology  and  pharmaceutical  industries  is
intense and we cannot assure you that we will be  successful in our  recruitment
efforts.  If we are  unable  to  retain  or,  when  needed,  attract  additional
qualified  personnel,  our operations also could be significantly  and adversely
affected.

We Face Substantial Competition in the Biotechnology Field and May Not Be Able
to Successfully Compete

         The biotechnology  industry is highly competitive,  particularly in the
area of cancer diagnostic and therapeutic  products.  We are likely to encounter
significant  competition  with respect to our  existing  products as well as our
products  currently  under  development.  A number of companies,  including IDEC
Pharmaceuticals,  Genentech,  SmithKline Beecham,  Nycomed Amersham, and Coulter
Pharmaceutical,  are engaged in the  biotechnology  field, and in particular the
development  of  cancer  diagnostic  and  therapeutic  products.  Many of  these
companies  have  significantly   greater  financial,   technical  and  marketing
resources  than  us.  In  addition,  many  of  these  companies  may  have  more
established positions in the pharmaceutical  industry and may be better equipped
than us to develop, refine and market their products.

         We also expect to face increasing  competition  from  universities  and
other  non-profit  research  organizations.   These  institutions  carry  out  a
significant  amount of research and  development in the field of  antibody-based
technology.  These  institutions  are  becoming  increasingly  more aware of the
commercial  value of their  findings and more active in seeking patent and other
proprietary rights, as well as licensing revenues.

Our Products May Be Rendered Obsolete By Rapid Technological Change

         We are  pursuing an area of product  development  in which there is the
potential for extensive technological innovations in relatively short periods of
time. We cannot assure you that our  competitors  will not succeed in developing
products that are safer or more effective than our products. Rapid technological
change or developments  by others may result in our current  products as well as
those in development becoming noncompetitive or obsolete.


                                      -8-
<PAGE>

If We Are Unable to Protect Our Intellectual Property Rights, We Could Lose Our
Competitive Advantage

         Our  commercial  success is highly  dependent  upon  patents  and other
proprietary  rights  that we own or license.  We cannot  assure you that our key
patents  will  not be  invalidated  or  will  provide  us  protection  that  has
commercial  significance.  Litigation  may be  necessary  to protect  our patent
positions,  which could be costly and time consuming.  If any of our key patents
that we own or license are invalidated,  our business may be  significantly  and
adversely  affected.  In addition,  other  companies may  independently  develop
similar  trade  secrets  or  know-how  or obtain  access  to our trade  secrets,
know-how or  proprietary  technology,  which could  significantly  and adversely
affect our business.

Our Products May Infringe Third Party Intellectual Property Rights

         Other companies may have filed  applications  for, or have been issued,
patents  and  obtained  other  proprietary  rights  to  technology  which may be
potentially useful to us. Since we do not have the resources to maintain a staff
whose primary  function is to  investigate  the level of protection  afforded to
third  parties on devices and  components  which we use in our  products,  it is
possible that a third party could  successfully claim that our products infringe
on their intellectual  property rights. If this were to occur, we may be subject
to substantial damages, and we may not be able to obtain appropriate licenses at
a cost we could  afford and we may not have the ability to timely  redesign  our
products.  If we are  required  to pay  damages  or are  unable to obtain  these
rights, our business could be significantly and adversely  affected.  Even if we
are successful in defeating any alleged  infringement  claims,  litigation could
result in a substantial diversion of managerial time and resources,  which could
be better and more fruitfully utilized on other activities.

Our Operations Could Suffer If We Are Unsuccessful in Our Pending Infringement
Claims Concerning Our CEA Antibodies

         We are involved in certain litigation with F.  Hoffmann-LaRoche and its
affiliates concerning the validity our European patents covering the antibody we
use in our CEA-Scan cancer imaging product and our  CEA-Cide(tm)  cancer therapy
product,  as well as the use of highly specific anti-CEA antibodies for a number
of other uses. We have claimed that they have infringed our patent and they have
counter-claimed  seeking to nullify the patents that were issued.  If we receive
an  unfavorable  outcome  in  any  of  these  matters,  our  business  could  be
significantly and adversely affected.

Product Liability Claims in Excess of the Amount of Our Insurance Would
Adversely Affect Our Financial Condition

         The  clinical  testing,  marketing  and  manufacturing  of our products
necessarily  involve  the risk of product  liability.  While we  currently  have
product  liability  insurance,  we cannot  assure that we will be able to obtain
insurance in the future at an acceptable  cost, if at all. If we cannot maintain
our existing or comparable liability  insurance,  our ability to test clinically
and market our products may be significantly impaired.  Moreover, the amount and
scope  of our  insurance  coverage  or  indemnification  arrangements  with  any
distributor or other third party upon which we rely may be inadequate to protect
us in the event of a successful  product liability claim. Any claim in excess of
the amount of any insurance we then had could significantly and adversely affect
our financial condition and operating results.

Our Principal Stockholder Can Influence Most Matters Requiring Approval By Our
Stockholders

         As of  December  31,  1999,  Dr.  Goldenberg,  our  Chairman  and Chief
Executive Officer,  controlled the right to vote over approximately 26.7% of our
common stock (excluding options to purchase 337,500 shares). As a result of this
voting power,  Dr.  Goldenberg may have the ability to determine the election of
all  of  our  directors,   direct  our  policies  and  control  the  outcome  of
substantially all matters which may be put to a vote of our stockholders.

                                      -9-
<PAGE>

Resales of Shares Held By Our Directors and Executive Officers May Lower the
Market Price of Our Common Stock

         As of December 31, 1999, we had a total of 46,260,121  shares of common
stock outstanding,  12,386,456 of which were held by our directors and executive
officers  (excluding options to purchase 940,625 shares).  These shares may only
be resold in limited quantities and only within the limitations  imposed by Rule
144 under the  Securities  Act.  The mere  prospect  that  these  shares  may be
publicly resold could lower the market price for our common stock.

Our Stock Price Has Been Volatile

         We believe  that a variety of factors  have caused the market  price of
our  common  stock to  fluctuate  substantially,  and that it will  continue  to
fluctuate in the future. These factors include:

*    actual or anticipated fluctuations in our operating results;

*    the status of our products in development;

*    new products or technical innovations by us or by our existing or potential
     competitors;

*    the formation or  termination of our corporate  alliances and  distribution
     arrangements;

*    prolonged  periods of  regulatory  review of new  products  or new uses for
     existing products;

*    determinations regarding our patent applications and those of others;

*    trading strategies occurring in the market place with respect to our common
     stock; and

*    general market  conditions and other factors unrelated to us or outside our
     control.

Potential Loss of Our Nasdaq Listing Could Make it More Difficult to Sell our
Shares and Affect Our Liquidity

         If the bid  price of our  common  stock  were to fall  below  $1.00 per
share,  if we were to have less than  $4,000,000  in net tangible  assets (total
assets less total liabilities and goodwill), or if the value of our common stock
held by our stockholders  (other than our directors and executive officers) were
to be less than  $5,000,000,  our common stock could be delisted from The Nasdaq
Stock Market.  If our common stock were delisted from Nasdaq,  trading,  if any,
would thereafter be conducted in the over-the-counter market. This would make it
more difficult for an investor to dispose of, or to obtain  accurate  quotations
for, our common  stock.  Additionally,  it may become more  difficult  for us to
raise funds through the sale of our securities.

Stockholders Could Be Adversely Affected By Our Anti-Takeover Provisions

         Our board of directors has the  authority,  without any further vote by
our stockholders,  to issue up to 10,000,000 shares of preferred stock in one or
more series and to determine the designations, powers, preferences and relative,
participating,  optional or other rights  thereof,  including the dividend rate,
whether dividends are cumulative,  conversion rights,  voting rights, rights and
terms of redemption,  redemption price and liquidation  preference.  Issuance of
preferred  stock could have the effect of delaying,  deterring  or  preventing a
change in control of our company,  or could impose various  procedural and other
requirements  that could make it more  difficult for holders of our common stock
to effect certain corporate actions,  including the ability to replace incumbent
directors  and to  accomplish  transactions  opposed by the  incumbent  board of
directors.

                                      -10-
<PAGE>

  The rights of the  holders of our common  stock would be subject to,
and may be  adversely  affected  by, the rights of the holders of any  preferred
stock that may be issued in the future.

Our Operations Could Be Affected By Year 2000 Issues

         Prior to December  31,  1999,  we  completed  a review of our  business
systems,  including our computer systems and manufacturing  equipment,  and sent
written  inquiries  to our  customers,  distributors  and  vendors  as to  their
progress in identifying  and addressing  problems that their systems may face in
correctly  interpreting  and processing date  information  relating to Year 2000
issues. While we have not yet experienced  significant  difficulties relating to
Year 2000 issues, we still could encounter problems with supplier and/or revenue
sources which could affect us. We cannot  accurately  predict the  occurrence or
outcome of any these  problems,  nor can we estimate the dollar  amount of these
problems.  In addition,  we cannot assure you that a failure by a third party to
ensure year 2000 compliance will not significantly and adversely effect us.

Stockholders Should Not Expect That We Will Pay Dividends

         We  have  never  paid  any  dividends  on our  common  stock.  For  the
foreseeable  future,  we expect to  retain  earnings,  if any,  to  finance  the
expansion and development of our business.  Any future payment of dividends will
be within  the  discretion  of our Board of  Directors  and will  depend  upon a
variety of factors, including our earnings, capital requirements,  and operating
and financial condition.

Special Note Regarding Forward-Looking Statements

         We have made  statements  in this  prospectus,  and in the documents we
incorporate  by  reference,  that are  "forward-looking  statements"  within the
meaning of the Securities Act and the Securities  Exchange Act.  Sometimes these
statements contain words like "may," "believe," "expect,"  "continue," "intend,"
"anticipate" or other similar words.  These  statements  could involve known and
unknown risks,  uncertainties and other factors that might  significantly  alter
the actual results suggested by the statements.  In other words, our performance
might be quite different from what the  forward-looking  statements  imply.  The
following  factors,  as well as those  discussed  above in this  "Risk  Factors"
section and in the documents which we incorporate by reference,  could cause our
performance to differ from the implied results:

*    inherent   uncertainties   accompanying   the  marketing  of  CEA-Scan  and
     LeukoScan.

*    inherent uncertainties involving new product development and marketing.

*    inability  to  obtain  capital  for  continued   product   development  and
     commercialization.

*    actions of regulatory authorities concerning product approval.

*    actions of government and private organizations concerning reimbursement of
     medical expenses.

*    impact of competitive products and pricing.

*    results of clinical trials.

*    loss of key employees.

*    changes in general economic and business conditions.

*    changes in industry trends.

                                      -11-
<PAGE>

We have no obligation to release  publicly the result of any revisions to any of
our  "forward-looking  statements" to reflect events or circumstances that occur
after  the  date of this  prospectus  or to  reflect  the  occurrence  of  other
unanticipated events.


                       WHERE YOU CAN FIND MORE INFORMATION

       We publicly file annual,  quarterly and current reports, proxy statements
and other  documents with the SEC. You may read and copy any of these  documents
at the SEC's public reference rooms, which are located at:

                          450 Fifth Street, N.W.
                          Washington, D.C.  20549

                          7 World Trade Center, Suite 1300
                          New York, New York  10048

                          500 West Madison Street, Suite 1400
                          Chicago, Illinois  60661-2511

         Please call the SEC at  1-800-SEC-0330  for further  information on the
public   reference   rooms.   The  SEC   maintains   an   Internet   website  at
http://www.sec.gov where our publicly filed documents may be obtained.

         This prospectus is part of a registration statement filed with the SEC.
Our  registration  statement  contains  more  information  than this  prospectus
regarding  us and our  common  stock  and  includes  supplemental  exhibits  and
schedules.  You can obtain a copy of the registration  statement from the SEC at
the address listed above or from its Internet website.

         The SEC allows us to  "incorporate  by reference"  into this prospectus
the  information we file with it. This means that we are deemed to be disclosing
such information to you by referring you to those documents. This information is
important and should be reviewed.  The information  incorporated by reference is
considered to be part of this  prospectus,  and later  information  that we file
with the SEC will  automatically  update and supercede the  information  in this
prospectus.

         We incorporate by reference into this  prospectus the documents  listed
below and any future filings we make with the SEC under Sections  13(a),  13(c),
14 or 15(d) of the Securities Exchange Act:

*    Annual Report on Form 10-K for the fiscal year ended June 30, 1999;

*    Proxy  Statement,  dated October 18, 1999,  with respect to our 1999 annual
     meeting of stockholders;

*    Quarterly  Report on Form 10-Q for the fiscal  quarter ended  September 30,
     1999;

*    Current Report on Form 8-K, dated November 24, 1999; and

*    Description  of our common stock  contained  in Item 1 of our  Registration
     Statement on Form 8-A, dated May 7, 1984.

         You may  request a copy of these  filings,  at no cost,  by  calling or
writing us at the following address:



                      Immunomedics, Inc.
                      300 American Road
                      Morris Plains, New Jersey 07950
                      (973) 605-8200
                      Attention:  Investor Relations

                                      -12-
<PAGE>

                                  IMMUNOMEDICS

Description of Our Business

         We are a biopharmaceutical  company,  which develops,  manufactures and
markets  products for the detection and treatment of cancers and other diseases.
These  products,  which are based on our  monoclonal  antibody  technology,  are
designed to deliver  radioisotopes,  chemotherapeutic  agents,  toxins,  dyes or
other substances to a specific disease site or organ system.

         We have received  approval from the respective  regulatory  agencies in
the United States,  the 15 member  countries of the European  Union,  Canada and
certain other countries to market and sell CEA-Scan  (arcitumomab),  our imaging
product for the detection of recurrent and/or metastatic colorectal cancer.

         We  also  have   received   approval  to  market  and  sell   LeukoScan
(sulesomab),  our imaging  product for detection and diagnosis of  osteomyelitis
(bone  infection) in long bones and in diabetic foot ulcer  patients,  in the 15
member  countries of the European Union.  We have filed an application  with the
FDA in the U.S. and the comparable  regulatory  agency in Canada for approval to
market  LeukoScan for the imaging of infection in  osteomyelitis  as well as for
the imaging of infection in acute, atypical  appendicitis.  We have been advised
by the FDA that there are still  deficiencies  with our application  relating to
the  adequacy  of our  data  necessary  to  support  final  approval  for  these
indications.  Despite our confidence  that we were making  progress with FDA and
had adhered to all agreements and guidelines, it is now clear to us that we need
to take whatever steps are available to us to gain a more receptive  audience in
order to gain marketing approval for this product. We can not assure you that we
will receive FDA approval for this product in a timely manner, or at all.

         Marketing, Sales and Distribution

         CEA-Scan  is  marketed  and sold in the U.S.  directly  by our  limited
internal sales force, who are focused on new customers in major medical centers.
Our skilled nuclear medicine  technicians work with this sales force and provide
technical support directly to our customers. We have entered into a distribution
arrangement in the U.S. with Integrated  Commercialization Solutions, a division
of Bergen Brunswig  Corporation,  to provide product support services  including
customer service, order management,  distribution,  invoicing and collection. We
also  have an  agreement  with  Syncor  International,  a  leading  provider  of
radiopharmacy  services,  under which  Syncor  makes  CEA-Scan  available to its
hospital and clinic  accounts  throughout  the U.S.,  supported by our sales and
technical support specialists.

         Our European  operations,  headquartered in Hillegom,  The Netherlands,
include  European  management,   sales  and  marketing,   customer  service  and
invoicing,   collection  and  other  administrative   functions.  We  also  have
established  sales  representation  in most major European  markets.  We service
other markets  through the appointment of local  distributors  who provide sales
and  marketing  support  as  well  as  local  product  distribution.  We have an
agreement with Eli Lilly Deutschland GmbH to package and distribute our products
throughout the 15 member countries of the European Union and other countries.

         Imaging Products

         Our imaging  products  involve  injecting a patient with a radioisotope
attached to an  antibody  fragment.  An antibody is a protein  that can find and
attach  itself to a specific  substance  called an antigen.  These  antigens are
present  on tumor  cells,  white  blood  cells that  accumulate  at the sites of
infections,   and  other  disease  entities.   A  radioisotope   attached  to  a
disease-targeting  antibody  is  delivered  to a  disease  site for  imaging.  A
standard  nuclear  medicine  imaging  camera is then used to detect and  display
radioisotope concentrations at various sites of disease.

                                      -13-
<PAGE>

         The antibody fragment in CEA-Scan is directed against  carcinoembryonic
antigen  (CEA),  which is abundant at the site of  virtually  all cancers of the
colon  or  rectum.  CEA also is  associated  with  many  other  cancers.  We are
conducting phase IV clinical trials to evaluate the product  following  repeated
administration. We also have been performing clinical trials using CEA- Scan for
imaging  lung cancer and breast  cancer.  We are  discussing  the results of our
breast cancer trials with European  regulatory  authorities to determine whether
the data will support the submission of applications for marketing approval.  In
addition,   we  are  continuing  our  efforts  in  developing  cancer  detection
applications with CEA-Scan utilizing  hand-held  radiation-detecting  probes for
use in colorectal cancer surgery.

         LeukoScan is a monoclonal antibody fragment, which seeks out, and binds
to white blood cells (granulocytes)  associated with a potentially wide range of
infectious and inflammatory diseases.

         We are studying the following two other  imaging  products  pursuant to
Investigational  New Drug  applications  that we have filed or plan to file with
the FDA and for which we have ongoing clinical trials:

*    LymphoScan(r), for non-Hodgkin's B-cell lymphomas.


*    AFP-Scan(r),  for liver  cancer and  germ-cell  tumors of the  ovaries  and
     testes.

       Therapeutic Products

         We are applying our expertise in antibody  selection,  modification and
  chemistry to cancer  therapeutics,  using monoclonal  antibodies  labeled with
  therapeutic  radioisotopes  or  conjugated  with  drugs.  We  are  engaged  in
  developing   anti-cancer   products,   principally  with  a  technique  called
  radioimmunotherapy. This technique may deliver radiolabeled therapeutic agents
  to tumor sites more selectively than current radiation  therapy  technologies,
  while minimizing  debilitating side effects. In addition, we are evaluating in
  clinical  trials  the  effects of our  non-radioactive  lymphoma  antibody  in
  non-Hodgkin's lymphoma patients.

       Research Programs

         In addition to concentrating  on our products in clinical  development,
we conduct ongoing research in many related areas. We conduct research  in-house
and in collaboration with The Center for Molecular Medicine and Immunology, also
known as the  Garden  State  Cancer  Center,  and other  academic  and  research
centers.  In March 1999, we entered into a joint venture with Beckman Coulter to
develop  the next  generation  of  cancer  radiotherapeutics  using  bi-specific
antibodies.  We believe our  ongoing  research  efforts  will  identify  new and
improved products and techniques for diagnosing and treating various cancers and
infectious  diseases.  However,  we cannot  assure you that such efforts will be
successful, given the complex issues involved in such diagnosis and treatment.

         Our research  efforts are focused in various  areas related to our core
technology,  including  antibody  engineering  and the  identification  of other
antibody-directed  approaches  to  cancer  therapy.  We  have  made  significant
progress in  humanizing  certain  mouse  antibodies  and have  reengineered  the
humanized antibodies with improved  characteristics.  We are continuing our work
on  selective  coupling  of  therapeutic  site  specific  agents  onto  antibody
fragments  which  will  offer the  advantage  of  loading  multiple  therapeutic
compounds  onto  antibodies  at a particular  disease  site. We also continue to
investigate  pre-targeting,  whereby an antibody is administered first, followed
by a radionuclide or drug administration.

                                      -14-
<PAGE>

         We also  are  continuing  our  research  into  the  use of  alternative
radioisotopes, such as Yttrium-90 in place of Iodine-131. Our research indicates
that  Yttrium-90 is retained by lymphoma cells for longer periods after antibody
metabolism,  and shows greater  efficacy  against  larger  tumors.  We also have
developed a technology using a compound called "DOTA" to tightly bind Yttrium-90
to antibodies.

         In addition,  we are continuing our efforts to scale-up our proprietary
method for technetium-99m radiolabeling of peptides, using single-vial kits.

December 1999 Financing

         On December 14, 1999, we entered into a Common Stock Purchase Agreement
with a small group of private  investors,  each of whom is described  below as a
selling  stockholder.  Under the Common Stock  Purchase  Agreement,  we sold the
investors a total of  2,500,000  shares of our common  stock at a price of $3.00
per share, for gross proceeds of $7,500,000.  We used  substantially  all of the
net  proceeds  from this sale to  redeem a total of 595  shares of our  Series F
Preferred Stock, representing all of the shares of Series F Preferred Stock that
had not been  converted  into common stock.  As a result,  we no longer have any
shares of Series F Preferred Stock outstanding.

         Under the Common Stock  Purchase  Agreement,  we were  required to make
certain promises to the investors. These covenants included the following:

*    We  agreed  to  register  with  the  SEC  the  shares  that  we sold to the
     investors. We promised to file a preliminary prospectus by January 13, 2000
     and thereafter to use our best efforts to have our  registration  statement
     declared  effective  by the  SEC as  expeditiously  as  possible.  We  were
     successful in filing our preliminary  prospectus  prior to the January 13th
     deadline.

*    We agreed to use the net proceeds to purchase the outstanding shares of our
     Series F Preferred Stock, as we have described above.

*    We agreed to refrain from entering into certain  transactions  with persons
     closely  related to our  company,  including  our  executive  officers  and
     directors,  without the prior  approval  of the  investors.  The  investors
     agreed not to withhold their approval unreasonably.

*    We agreed that without the prior consent of the investors,  we may not sell
     our business to anyone that is an affiliate of the company, unless the sale
     is for  consideration  at least equal to (a) the fair  market  value in the
     event of a sale of  assets  (as  determined  in good  faith by our board of
     directors)  or (b) the then current  market price in the event of a sale of
     stock.

*    We  agreed  that we would not amend our  certificate  of  incorporation  or
     by-laws in a manner that would adversely affect the investors,  without the
     prior approval of the investors. The investors agreed not to withhold their
     approval unreasonably.

*    We agreed that if, during a six month period  specified in our Common Stock
     Purchase Agreement,  we issue shares of our common stock at a price of less
     than  $3.00,  we will  issue  additional  shares  of  common  stock  to the
     investors to protect them against dilution without requiring any additional
     payment from the investors. This covenant is subject to certain exceptions;
     among  other  things,  no such  adjustment  will be  required if shares are
     issued below that price upon exercise or conversion of options, warrants or
     convertible  securities  outstanding  on December 14, 1999 or in connection
     with corporate partnering transactions, including mergers. Furthermore, the
     calculation  of the  adjustment is to be made on a weighted  average basis.
     Thus, if the number of shares that we issue in a non-exempt  transaction is
     not significant , or if the per share price in a non-exempt  transaction is
     only slightly below the trigger price,  we would not be required to issue a
     substantial number of additional shares to the investors.

*    We agreed that if, during the twelve  months  ending  December 31, 2000, we
     desire to conduct a private placement of our securities through a placement
     agent,  broker-dealer or finder, we will give an entity associated with the
     investors a right of first refusal to serve as the placement  agent in that
     transaction.

                                      -15-
<PAGE>

These  covenants  will  cease to apply at such time as the  investors  and their
affiliates beneficially own less than 5% of our common stock. As of December 30,
1999, such investors in the aggregate beneficially owned 6.2% of our outstanding
common stock.  Prior to the time, if any, when the  investors'  equity  interest
falls below 5%, the  investors  may waive any one or more of the  covenants  set
forth in our Common Stock Purchase Agreement.

         In  connection   with  the  execution  of  our  Common  Stock  Purchase
Agreement,  our executive  officers and directors have agreed that, subject to a
limited carve-out, they will not sell any shares of their common stock until the
later of June  14,  2000 or the date on which  the SEC  declares  effective  the
registration  statement of which this  prospectus  is a part.  We also agreed to
refrain  from  publicly  offering  or selling our shares for a period of 60 days
after the SEC declares such registration statement effective.
The investors may waive these restrictions at any time.

Agreement with Financial Advisor

         We  have  entered  into an  agreement  with  Sutro  & Co.  Incorporated
pursuant  to which  Sutro may serve as our  financial  advisor  with  respect to
various corporate finance and corporate partnering transactions.  As part of the
consideration  payable  to Sutro  for its  services,  we have  issued to Sutro a
Warrant  entitling  Sutro to purchase up to 75,000  shares of our common  stock.
This  Warrant has an  exercise  price of $6.50 per share and expires in December
2004. The Warrant grants Sutro certain registration rights,  including the right
to include in this  prospectus  the 75,000 shares of common stock  issuable upon
exercise of the Warrant.


                                 USE OF PROCEEDS

         We will not receive any  proceeds  from the sale of our common stock by
the selling  stockholders.  However, we did receive gross proceeds of $7,500,000
from the  issuance of our common stock to the  investors  in the  December  1999
financing.  We used  substantially  all of those  proceeds  to redeem all of the
remaining  outstanding  shares of Series F Preferred Stock and to cover expenses
relating to this financing.


                                      -16-
<PAGE>



                              SELLING STOCKHOLDERS

         The table below presents the following  information:  (1) the number of
shares of common  stock  beneficially  owned by each selling  stockholder  as of
December  31,  1999;  (2) the number of shares that the selling  stockholder  is
offering  under this  prospectus,  and (3) the number of shares that the selling
stockholder  will  beneficially  own  after  the  completion  of this  offering,
assuming that the selling  stockholder  does not acquire any other shares of our
common stock  subsequent  to December  31,  1999.  The number of shares shown as
being beneficially owned by each selling  stockholder after the offering assumes
that the selling  stockholder  has sold all the shares of our common stock which
may be sold pursuant to this prospectus.

         The number and percentage of shares  beneficially owned by each selling
stockholder is determined as of the date of this  prospectus in accordance  with
Rule  13d-3  of  the  Securities  Exchange  Act,  and  the  information  is  not
necessarily indicative of beneficial ownership for any other purpose. Under this
rule,  beneficial  ownership  includes  any  shares  as  to  which  the  selling
stockholder  has sole or shared  voting power or  investment  power and also any
shares which the selling  stockholder has the right to acquire within 60 days of
the date of this prospectus through the exercise of any stock option, warrant or
other right. Unless otherwise  indicated in the footnotes,  each person has sole
voting and  investment  power with respect to the shares  shown as  beneficially
owned.

         None of the selling  stockholders has had a material  relationship with
us  within  the  past  three  years,   other  than  as  described   above  under
"Immunomedics  - December 1999  Financing"  and  "Immunomedics  - Agreement with
Financial Advisor."

<TABLE>
<CAPTION>
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
Selling Stockholder                           Shares of Common         Shares of Common           Shares of Common
                                              Stock Beneficially       Stock Being Offered        Stock Beneficially
                                              Owned as of                                         Owned After the
                                              December 31, 1999                                   Offering
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
<S>                                           <C>                      <C>                        <C>
Sutro & Company, Inc.                                   75,000                   75,000                         --
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
Investors Under the Common Stock Purchase
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
   The Aries Master Fund                             1,814,053                1,557,645                    256,408
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
   The Aries Domestic Fund, L.P.                       727,965                  626,820                    101,145
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
   The Aries Domestic Fund II, L.P.                     56,814                   48,867                      7,947
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
   Lindsay A. Rosenwald, M.D.                       2,765,4991                  166,667                   365,5003
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
   Mark C. Rogers, M.D.                             2,632,1662                   33,334                   365,5003
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
   Wayne Rothbaum                                       66,667                   66,667                         --
- --------------------------------------------- ------------------------ -------------------------- ---------------------------
- -------------------
</TABLE>
1    Includes  1,814,053  shares of common stock owned by The Aries Master Fund,
     727,965 shares of common stock owned by The Aries  Domestic Fund,  L.P. and
     56,814 shares of common stock owned by The Aries Domestic Fund II, L.P. Dr.
     Rosenwald is the Chairman and sole  stockholder of Paramount  Capital Asset
     Management,  Inc. ("PCAM"),  which serves as the general partner to each of
     The Aries Domestic Fund, L.P., and The Aries Domestic Fund II, L.P., and as
     the investment manager to The Aries Master Fund. As such, Dr. Rosenwald and
     PCAM may be deemed to  beneficially  own the securities held by each of The
     Aries Domestic  Fund,  L.P., The Aries Domestic Fund II, L.P. and The Aries
     Master Fund. Dr. Rosenwald and PCAM disclaim  beneficial  ownership of such
     shares except to the extent of their pecuniary interest therein, if any.

                                      -17-
<PAGE>

2    Includes  1,814,053  shares of common stock owned by The Aries Master Fund,
     727,965 shares of common stock owned by the Aries  Domestic Fund,  L.P. and
     56,814 shares of common stock owned by the Aries Domestic Fund II, L.P. Dr.
     Rogers is the President of PCAM. As such, Dr. Rogers and PCAM may be deemed
     to  beneficially  own the  securities  held by each of Aries Domestic Fund,
     L.P.,  Aries  Domestic Fund II, L.P. and The Aries Master Fund.  Dr. Rogers
     and PCAM disclaim beneficial  ownership of such shares except to the extent
     of their pecuniary interest therein, if any.
3    Represents  256,408  shares of common stock owned by The Aries Master Fund,
     101,145 shares of common stock owned by The Aries  Domestic Fund,  L.P. and
     7,947 shares of common stock owned by The Aries Domestic Fund II, L.P.


                              PLAN OF DISTRIBUTION

Manner of Sales; Broker-Dealer Compensation

         The selling stockholders,  or any successors in interest to the selling
stockholders,  may sell any  shares  of our  common  stock  that  they  acquired
pursuant to our Common stock  Purchase  Agreement or that Sutro may acquire upon
exercise of its Warrant.  The sale of our common stock may be effected in one or
more of the following methods:

*    ordinary brokers' transactions;

*    transactions  involving  cross or block  trades or  otherwise on the Nasdaq
     National Market;

*    purchases by brokers,  dealers or  underwriters  as principal and resale by
     these purchasers for their own accounts pursuant to this prospectus;

*    "at the market" to or through market makers or into an existing  market for
     our common stock;

*    in other ways not involving  market makers or established  trading markets,
     including direct sales to purchasers or sales effected through agents;

*    through  transactions  in  options,  swaps  or other  derivatives  (whether
     exchange-listed or otherwise);

*    in privately negotiated transactions;

*    to cover  short  sales,  except  to the  extent  that  they are  restricted
     contractually from doing so; or

*    any combination of the foregoing.

The selling  stockholders  also may sell their shares in reliance  upon Rule 144
under the Securities Act at such times as they are eligible to do so.

         We have been  advised by the  selling  stockholders  that they have not
made any  arrangements  for the  distribution  of the  shares of  common  stock.
Brokers,  dealers or underwriters who effect sales for the selling  stockholders
may arrange for other brokers, dealers or underwriters to participate.  Brokers,
dealers  or  underwriters  engaged  by the  selling  stockholders  will  receive
commissions  or  discounts  from them in amounts to be  negotiated  prior to the
sale. These brokers, dealers or underwriters may act as agent or as principals.

                                      -18-
<PAGE>

         From time to time, one or more of the selling  stockholders may pledge,
hypothecate or grant a security  interest in some or all of the shares of common
stock  acquired by them,  and the pledgees,  secured  parties or persons to whom
these  securities  have been pledged  shall,  upon  foreclosure  in the event of
default, be considered a selling stockholders hereunder. In addition, subject to
contractual  limitations,  a selling  stockholder  may, from time to time,  sell
short our common stock. In these instances,  this prospectus may be delivered in
connection with these short sales.

         From time to time one or more of the selling stockholders may transfer,
pledge,  donate or assign shares of our common stock that it acquired to lenders
or others and each of these persons will be considered a selling stockholder for
purposes  of  this  prospectus.  The  number  of  shares  of  our  common  stock
beneficially owned by those selling stockholders who so transfer, pledge, donate
or assign  shares of our common stock will  decrease as and when they take these
actions.  The  plan  of  distribution  for  our  common  stock  by  the  selling
stockholders set forth herein will otherwise remain  unchanged,  except that the
transferees,  pledgees,  donees or other  successors will be considered  selling
stockholders hereunder.

         Subject to contractual  limitations,  a selling  stockholder  may enter
into hedging  transactions with broker-dealers and the broker-dealers may engage
in short sales of our common stock in the course of hedging the  positions  they
assume with this selling stockholder, including in connection with distributions
of our common  stock by these  broker-dealers.  A selling  stockholder  may also
enter into option or other  transactions  with  broker-dealers  that involve the
delivery  of our  common  stock to the  broker-dealers,  who may then  resell or
otherwise  transfer these shares. A selling  stockholder also may loan or pledge
our common stock to a broker-dealer  and the  broker-dealer  may sell our common
stock so loaned or upon a default  may sell or  otherwise  transfer  the pledged
common stock.

Filing of a Post-Effective Amendment In Certain Instances

         If any  selling  stockholder  notifies  us that it has  entered  into a
material arrangement (other than a customary brokerage account agreement) with a
broker or dealer for the sale of shares of common  stock  under this  prospectus
through a block trade, purchase by a broker or dealer or similar transaction, we
will file a post- effective  amendment to the  registration  statement under the
Securities Act. The post-effective amendment will disclose:

*    The name of each broker-dealer involved in the transaction.

*    The number of shares of common stock involved.

*    The price at which those shares of common stock were sold.

*    The   commissions   paid  or  discounts  or  concessions   allowed  to  the
     broker-dealer(s).

*    If   applicable,   that  these   broker-dealer(s)   did  not   conduct  any
     investigation  to verify  the  information  contained  or  incorporated  by
     reference in this prospectus, as supplemented.

*    Any other facts material to the transaction.

Certain Persons May Be Deemed to Be Underwriters

         The selling  stockholders and any  broker-dealers who execute sales for
them may be deemed to be "underwriters" within the meaning of the Securities Act
because  of the  number of shares of common  stock to be sold or resold by these
persons or entities or the manner of sale of these shares, or both. If a selling
stockholder  or  any  broker-dealer  or  other  holders  were  determined  to be
underwriters,  any discounts,  concessions or commissions received by them or by
brokers or dealers  acting on their  behalf and any profits  received by them on
the resale of their  shares of common  stock might be deemed to be  underwriting
discounts and commissions under the Securities Act.

                                      -19-
<PAGE>

Regulation M

         We have informed the selling stockholders that Regulation M promulgated
under the Securities  Exchange Act may be applicable to them with respect to any
purchase or sale our common  stock.  In  general,  Rule 102 under  Regulation  M
prohibits  any person  connected  with a  distribution  of our common stock from
directly or indirectly  bidding for, or  purchasing  for any account in which it
has a beneficial interest,  any of our common stock or any right to purchase our
common  stock,  for a period of one business day before and after  completion of
its participation in the distribution.

         During any  distribution  period,  Regulation  M prohibits  the selling
stockholders and any other persons engaged in the distribution  from engaging in
any  stabilizing  bid or  purchasing  our common stock except for the purpose of
preventing  or retarding a decline in the open market price of our common stock.
None of these persons may effect any  stabilizing  transaction to facilitate any
offering  at the market.  As the selling  stockholders  will be  reoffering  and
reselling  our common stock at the market,  Regulation M will prohibit them from
effecting any  stabilizing  transaction  in  contravention  of Regulation M with
respect to our common stock.

Indemnification and Other Matters

         We paid all of the expenses incident to the registration,  offering and
sale of our common  stock by the selling  stockholders  to the public other than
commissions or discounts of underwriters, broker-dealers or agents. We also have
agreed to indemnify the selling stockholders and certain related persons against
certain liabilities,  including liabilities under the Securities Act. Insofar as
indemnification  for  liabilities  arising  under  the  Securities  Act  may  be
permitted to our  directors,  officers  and  controlling  persons,  we have been
advised that in the opinion of the SEC this indemnification agreement is against
public  policy  as  expressed  in  the   Securities   Act  and  is,   therefore,
unenforceable.

         This  offering will  terminate on the date on which all shares  offered
hereby have been sold by the selling stockholders.

                                  LEGAL MATTERS

 Lowenstein Sandler PC will give its opinion on the validity of the common stock

                                     EXPERTS

         Our consolidated financial statements as of June 30, 1999 and 1998, and
for each of the years in the  three-year  period  ended June 30,  1999 have been
incorporated by reference herein and in the  registration  statement in reliance
upon  the  report  of  KPMG  LLP,  independent   certified  public  accountants,
incorporated by reference herein, and upon the authority of said firm as experts
in accounting and auditing.



                                      -20-
<PAGE>

                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.  Other Expenses of Issuance and Distribution.

The following is an itemized  statement of the estimated amounts of all expenses
payable by us in connection with the registration of the Shares:

SEC registration fee......................................             $   8,328
Legal fees and expenses...................................                10,000
Accounting fees and expenses..............................                 4,500
Miscellaneous expenses....................................                 2,172
                                                                       ---------
           Total..........................................             $  25,000
           =====                                                       =========

Item 15.  Indemnification of Directors and Officers.

         The Delaware  General  Corporation  Law provides,  in  substance,  that
Delaware  corporations shall have the power, under specified  circumstances,  to
indemnify  their  directors,  officers,  employees and agents in connection with
actions  or suits by or in the right of the  corporation,  by reason of the fact
that they were or are such directors,  officers,  employees and agents,  against
expenses  (including  attorneys'  fees) and,  in the case of  actions,  suits or
proceedings brought by third parties, against judgments,  fines and amounts paid
in  settlement  actually and  reasonably  incurred in any such  action,  suit or
proceeding.

         The Company's  Certificate  of  Incorporation  provides that a director
shall not be personally  liable to the Company or its  stockholders for monetary
damages for breach of fiduciary duty as a director  except for liability (i) for
breach of the  director's  duty of loyalty to the  Company or its  stockholders,
(ii) for acts or  omissions  not in good  faith  or  which  involve  intentional
misconduct  or a  knowing  violation  of law,  (iii)  under  Section  174 of the
Delaware  General  Corporation  Law, or (iv) for any transaction  from which the
director derived an improper personal benefit. The Company's Bylaws also provide
that the Company may indemnify its directors, officers and legal representatives
to the fullest extent  permitted by Delaware law against all awards and expenses
(including attorneys' fees).

Item 16.   Exhibits.

Exhibit No.             Description

4.1      -       Common Stock Purchase Agreement, dated as of December 14, 1999,
                 by  and  among  the Company and the investors named therein, as
                 amended by a side letter dated January 7, 2000.

4.2      -       Warrant, dated as of December 16, 1999, issued by the Company.

5.1      -       Opinion of Lowenstein Sandler PC

23.1     -       Consent of KPMG LLP.

23.2     -       Consent of Lowenstein Sandler PC
                 (included in their opinion filed as Exhibit 5.1).

24.1     -       Power of Attorney (included on the signature page).

                                      II-1
<PAGE>

Item 17.  Undertakings.

         The Company hereby  undertakes  that,  for purposes of determining  any
liability under the Securities Act of 1933, each filing of the Company's  annual
report pursuant to section 13(a) or section 15(d) of the Securities Exchange Act
of 1934 (and, where applicable, each filing of an employee benefit plan's annual
report pursuant to section 15(d) of the Securities Exchange Act of 1934) that is
incorporated by reference in the registration  statement shall be deemed to be a
new registration  statement relating to the securities offered therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

         The Company undertakes that it will:

                      (1) File,  during  any  period in which it offers or sells
                      securities,    a   post-effective    amendment   to   this
                      registration statement to:

                           (i)  Include any prospectus required by section 10(a)
                      (3) of the Securities Act;

                           (ii)  Reflect in the  prospectus  any facts or events
                      which,  individually or together,  represent a fundamental
                      change in the information in the registration statement.

                      Notwithstanding the foregoing, any increase or decrease in
                      volume of securities offered (if the total dollar value of
                      securities   offered  would  not  exceed  that  which  was
                      registered)  and any deviation from the low or high end of
                      the estimated  maximum  offering range may be reflected in
                      the form of prospectus filed with the Commission  pursuant
                      to Rule 424(b) if, in the aggregate, the changes in volume
                      and  price  represent  no more  than a 20%  change  in the
                      maximum   aggregate   offering  price  set  forth  in  the
                      "Calculation of  Registration  Fee" table in the effective
                      registration statement.

                           (iii) Include any material  information  with respect
                      to the plan of  distribution  not previously  disclosed in
                      the registration statement or any material changes to such
                      information in the registration statement.

                      provided,  however, that the Company does not need to give
                      the  statements  in  paragraph  (1)(i) and  (1)(ii) if the
                      information  required  in a  post-effective  amendment  is
                      incorporated  by reference from periodic  reports filed by
                      the Company under the Exchange Act.

                      (2) For  determining  liability  under the Securities Act,
                      treat each post-effective  amendment as a new registration
                      statement of the securities  offered,  and the offering of
                      the  securities  at that time to be the initial  bona fide
                      offering.

                      (3)  File  a  post-effective   amendment  to  remove  from
                      registration  any of the securities  that remain unsold at
                      the end of the offering.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 (the "Act") may be permitted to directors,  officers and controlling
persons of the Company pursuant to the foregoing provisions,  or otherwise,  the
Company has been  advised  that in the opinion of the  Securities  and  Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore,  unenforceable. In the event that a claim for indemnification
against  such  liabilities  (other  than the  payment by the Company of expenses
incurred or paid by a director,  officer or controlling person of the Company in
the  successful  defense of any action,  suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered,  the Company  will,  unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.

                                      II-2
<PAGE>

                                   SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
Registrant  certifies that it has reasonable  grounds to believe it meets all of
the  requirements  for filing on Form S-3 and has duly caused this  Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the City of Morris  Plains,  State of New Jersey,  on January 7,
2000.

                                               IMMUNOMEDICS, INC.


                                               By: /s/ David M. Goldenberg
                                                   David M. Goldenberg
                                                   Chairman of the Board and
                                                   Chief Executive Officer
                                                   (Principal Executive Officer)

         Each person whose  signature  appears  below  constitutes  and appoints
David M.  Goldenberg,  Cynthia  Sullivan and Shailesh R. Asher and each of them,
his or her true and lawful attorney-in-fact, with full power of substitution and
resubstitution,  for him or her and in his or her name,  place and stead, in any
and all  capacities  to sign any and all  amendments,  including  post-effective
amendments,  to this  Registration  Statement,  and to file the  same,  with all
exhibits  thereto,  and  other  documents  in  connection  therewith,  with  the
Securities and Exchange  Commission  under the  Securities  Act of 1933,  hereby
ratifying and confirming  all that said  attorneys-in-fact  or  substitutes  may
lawfully do or cause to be done by virtue thereof.

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has been signed below by the  following  persons in the
capacities and on the dates indicated.

Dated:

January 7, 2000                                    /s/ David M. Goldenberg
                                                   -----------------------------
                                                   David M. Goldenberg, Chairman
                                                   of the Board, Chief Executive
                                                   Officer and a Director
                                                   (Principal Executive Officer)

January 7, 2000                                    /s/ Marvin E. Jaffe
                                                   -----------------------------
                                                   Marvin E. Jaffe, Director

January 7, 2000                                    /s/ Richard R. Pivirotto
                                                   -----------------------------
                                                   Richard R. Pivirotto,
                                                   Director

January 7, 2000                                    /s/ Richard C. Williams
                                                   -----------------------------
                                                   Richard C. Williams, Director

January 7, 2000                                    /s/ Shailesh R. Asher
                                                   -----------------------------
                                                   Shailesh R. Asher, Controller
                                                   and Acting Chief Financial
                                                   Officer (Principal Financial
                                                   and Accounting Officer)

                                      II-3
<PAGE>

                                  EXHIBIT INDEX


      4.1        Common Stock Purchase Agreement, dated as of December 14, 1999,
                 by and among the Company and the investors named therein, as
                 amended by a side letter dated January 7, 2000.

      4.2        Warrant, dated as of December 16, 1999, issued by the Company

      5.1        Opinion of Lowenstein Sandler LP

     23.1        Consent of KPMG LLP.

                                      II-4
<PAGE>


                               Immunomedics, Inc.
                               300 American Road
                             Morris Plains, NJ 07950
                                  973-605-8200



                                 January 7, 2000


The Aries Master Fund
The Aries Domestic Fund, L.P.
The Aries Domestic Fund II, L.P.
Lindsay A. Rosenwald, M.D.
Mark C. Rogers, M.D.
Wayne Rothbaum
c/o Paramount Capital Asset Management, Inc.
787 7th Avenue, 48th Floor
New York, NY  10019

Attention:  David M. Tanen

Gentlemen:

This  letter is written to confirm  our  understanding  with  respect to certain
matters addressed in the Common Stock Purchase  Agreement,  dated as of December
14, 1999 (the  "Agreement"),  among us. Terms that are not otherwise  defined in
this letter have the same meanings as in the Agreement.

We have agreed to delete the first  sentence of Section 7.7 of the Agreement and
to insert in its place the following language:

"Without  the prior  consent of the  Purchasers,  the  Company  may not sell its
business  (either by way of a sale or  transfer  of assets,  sale or transfer of
stock, merger or otherwise) to any person or entity that is, prior to such sale,
an  "Affiliate"  of the Company,  unless such transfer is for  consideration  at
least equal to (a) the Fair  Market  Value in the event of a sale or transfer of
assets or (b) the then  Current  Market Price in the event of a sale or transfer
of stock.  The "Fair  Market  Value" of any asset of the Company  means the fair
market  value  thereof as  determined  in good faith by the  Company's  Board of
Directors.  The then "Current  Market Price" per share shall be deemed to be the
last sale price of the Common  Stock on the  trading  date prior to such sale or
transfer or, in case no such  reported sale takes place on such day, the average
of the last  reported  bid and asked  prices of the Common Stock on such day, in
either case on the principal  national  securities  exchange on which the Common
Stock is admitted to trading or listed,  or if not listed or admitted to trading
on any such exchange,  the representative  closing bid price of the Common Stock
as reported by the National Association of Securities Dealers, Inc. Automated

<PAGE>

Quotation  System  ("Nasdaq"),  or other  similar  organization  if Nasdaq is no
longer  reporting such  information,  or, if the Common Stock is not reported on
Nasdaq,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined in good faith by the Company's Board of Directors. For purposes of
this Agreement,  the term "Affiliate"  means any person or entity that controls,
is controlled by or is under common control with the Company."

We further agree that the change  described above  represents the only change to
the  Agreement  and the remaining  provisions  contained in the Agreement  shall
remain unchanged and in effect.


Kindly  acknowledge  your  agreement  with the terms of this  letter by  signing
below.

Very truly yours,

IMMUNOMEDICS, INC.


By: /s/David M. Goldenberg, M.D.
_________________________________
      David M. Goldenberg, M.D.
      Chairman and Chief Executive Officer

DMG:wjh
Enclosures

Acknowledged and agreed to:

THE ARIES MASTER FUND


By: /s/ Lindsay A. Rosenwald, M.D.
_________________________________

                                      -2-
<PAGE>

THE ARIES DOMESTIC FUND, L.P.


By: /s/ Lindsay A. Rosenwald, M.D.
_________________________________

THE ARIES DOMESTIC FUND II, L.P.


By: /s/ Lindsay A. Rosenwald, M.D.
_________________________________

/s/ Lindsay A. Rosenwald, M.D.
- -------------------------------------
Lindsay A. Rosenwald, M.D.

/s/ Marc C. Rogers, M.D.
- -------------------------------------
Mark C. Rogers, M.D.


- -------------------------------------
Wayne Rothbaum


                                      -3-
<PAGE>


                                    COMMON  STOCK   PURCHASE   AGREEMENT   (this
                           "Agreement")  dated as of December 14,  1999,  by and
                           among IMMUNOMEDICS, INC., a Delaware corporation (the
                           "Company"),  and the  PURCHASERS  listed on Exhibit A
                           ("Purchasers").

                  The  Company  desires  to issue  and sell to  Purchasers,  and
Purchasers desire to purchase from the Company,  shares (the "Common Shares") of
the Company's common stock,  par value $.01 per share (the "Common  Stock"),  at
$3.00 per share  (the  "Per  Share  Price")  upon and  subject  to the terms and
conditions of this Agreement.

                  Accordingly,  in  consideration of the premises and the mutual
agreements  contained  herein,  and for other good and  valuable  consideration,
Purchasers and the Company agree as follows:

                  1.       Purchase of Company Securities.

                  1.1.  Purchase and Sale of the Common  Shares.  (a) Subject to
the terms and conditions of this Agreement, (i) the Company shall issue and sell
to Purchasers,  and Purchasers,  severally and not jointly,  shall purchase from
the  Company,  2,500,000  shares  of  Common  Stock as set  forth on  Exhibit  A
(allocated  among the  Purchasers  as set forth on Exhibit  A).  Such  shares of
Common Stock are  hereinafter  sometimes  referred to as the  "Securities."  The
aggregate  purchase  price  for the  Common  Shares  shall  be  $7,500,000  (the
"Aggregate  Purchase  Price")  (allocated  among the  Purchasers as set forth on
Exhibit A).

                  2.       Closing.

                  2.1.  Closing.  The  closing of the  purchase  and sale of the
Common  Shares shall take place at a single  closing at the offices of Paramount
Capital Asset Management, Inc. ("Paramount"), at 787 Seventh Avenue, 48th Floor,
New York,  New  York,  10019.  Such  closing  (the  "Closing")  will take  place
contemporaneously with the execution and delivery of this Agreement. The date of
the Closing is referred to as the "Closing  Date." At the  Closing,  the Company
will deliver to Purchasers  the Common Shares  against  payment of the Aggregate
Purchase Price by Purchasers by wire transfer payable to the Company pursuant to
the  instructions  attached  hereto as  Exhibit B. The  Common  Shares  shall be
registered  in  Purchasers'  names  in such  denominations  as are set  forth on
Exhibit A annexed hereto.

                  3. Conditions to the Obligations of Purchasers at the Closing.
The  obligation  of  Purchasers  to purchase and pay for the Common Shares to be
purchased  by  Purchasers  at the Closing is subject to the  satisfaction  on or
prior to the Closing Date of the following conditions,  which may only be waived
by written consent of Purchasers:

                  3.1. Opinion of Counsel to the Company.  Purchasers shall have
received from Lowenstein Sandler PC, counsel for the Company,  its opinion dated
the Closing Date in the form of Exhibit C.

<PAGE>

                  3.2. Representations  and  Warranties.  All  of the
representations  and warranties of the Company contained in this Agreement shall
be true and correct at and as of the Closing Date.

                  3.3.  Performance  of  Covenants.  All  of the  covenants  and
agreements of the Company  contained in this Agreement  required to be performed
on or  prior  to  the  Closing  Date  shall  have  been  performed  in a  manner
satisfactory in all respects to Purchasers.

                  3.4. Legal Action. No injunction, order, investigation, claim,
action or proceeding  before any court or governmental  body shall be pending or
threatened  wherein an  unfavorable  judgment,  decree or order would  restrain,
impair or prevent the carrying out of this Agreement or any of the  transactions
contemplated  thereby,  declare unlawful the  transactions  contemplated by this
Agreement or cause any such transaction to be rescinded.

                  3.5.  Consents.  The Company shall have obtained in writing or
made  all  consents,   waivers,   approvals,   orders,  permits,   licenses  and
authorizations of, and registrations,  declarations,  notices to and filings and
applications  with, any governmental  authority or any other Person  (including,
without limitation, securityholders and creditors of the Company) required to be
obtained  or made in order to enable the  Company to observe and comply with all
of its  obligations  under this  Agreement  and to  consummate  and  perform the
transactions  contemplated  hereby.  The Board of Directors of the Company shall
have taken all action required to permit the  transactions  contemplated by this
Agreement.

                  3.6.   Closing Documents.  The Company shall have delivered to
Purchasers the following:

                  (a) a  certificate  executed  on behalf of the  Company by the
Chairman  and Chief  Executive  Officer of the Company  dated the  Closing  Date
stating  that the  conditions  set forth in  Sections  3.2 through 3.5 have been
satisfied;

                  (b) a certificate  of the Secretary of the Company,  dated the
Closing Date, as to the continued and valid existence of the Company, certifying
the  attached  copy of the  By-laws of the  Company,  the  authorization  of the
execution,  delivery and  performance  of this  Agreement,  and the  resolutions
adopted by the Board of Directors of the Company  authorizing  the actions to be
taken by the Company under this Agreement;

                  (c) a  certificate  of the  Secretary of State of the State of
Delaware,  dated a  recent  date,  to the  effect  that the  Company  is in good
standing in the State of Delaware and that all annual reports, if any, have been
filed as required and, if readily  available  that all franchise  taxes and fees
have been paid in connection therewith;

                  (d) a certified copy of the  Certificate of  Incorporation  of
the  Company  as filed  with the  Secretary  of State of the State of  Delaware,
including any amendments thereto; and

                                       2
<PAGE>

                  (e) such  certificates,  other  documents and  instruments  as
Purchasers and their counsel may reasonably  request in connection  with, and to
effect, the transactions contemplated by this Agreement.

                  3.7. Proceedings. All corporate and other proceedings taken or
to be taken in connection with the  transactions  contemplated by this Agreement
to be  consummated at such Closing and all documents  incident  thereto shall be
satisfactory in form and substance to Purchasers.

                  3.8. Closing Financial Statements; Absence of Changes. (a) The
Company shall have provided to Purchasers  (i) the unaudited  balance  sheets of
the Company as of September 30, 1999,  and the related  unaudited  statements of
operations, and cash flows for the three-month period then ended (the "Financial
Statements"),  all of which will be correct and complete and will present fairly
the financial position of the Company and the results of its operations and cash
flows as of the time and for the periods  then  ended,  provided  adjusting  and
closing  entries  ordinarily  made at the close of any such period in connection
with audit,  and footnote  information,  are omitted,  and (ii) the  unqualified
certification,  in form and substance  satisfactory to Purchasers,  of the Chief
Financial Officer of the Company, acting on behalf of the Company, to the effect
that the Financial  Statements  have been prepared in accordance  with the books
and records of the Company and generally accepted accounting  principles applied
on a basis  consistent  with prior years (except as otherwise  specified in such
certification), and present fairly the financial position of the Company and the
results of its  operations  cash flows as of the time and for the  periods  then
ended,  provided  adjusting and closing entries  ordinarily made at the close of
any such period in connection with audit, and footnote information, are omitted.

                  (b) Except as set forth on the schedules to this  Agreement or
as previously publicly disclosed,  and except for net losses consistent in scope
with net losses  incurred by the Company during the nine months ended  September
30,  1999,  there shall have been no material  adverse  change in the  business,
financial  condition,  operating  results,  employee  or customer  relations  or
prospects of the Company, from September 30, 1999 to the Closing Date.

                  3.9. Schedules.  The Company shall have provided to Purchasers
all schedules  required  pursuant to this  Agreement,  which  schedules shall be
satisfactory to Purchasers in their sole discretion.

                  3.10. Material Agreements.  The Company shall have provided to
the  Purchasers  a copy of  agreements  entered by and among the Company and all
holders of its  Series F  Convertible  Preferred  Stock  pursuant  to which such
holders have agreed that the Company may redeem all outstanding shares of Series
F Preferred  Stock at any time on or before  December 31, 1999, at a price equal
to 109% of the stated value of such Series F Convertible  Preferred Stock (which
is $10,000).

                  4.  Conditions  to  the  Obligations  of  the  Company  at the
Closings.  The  obligation of the Company to issue and sell the Common Shares to
the Purchasers at the Closing is subject to the  satisfaction on or prior to the
Closing  Date of the  following  conditions,  any of which  may be waived by the
Company:

                                       3
<PAGE>

                  4.1.  Representations and Warranties.  The representations and
warranties of Purchasers  contained in this Agreement  shall be true and correct
at and as of the Closing Date.

                  4.2. Legal Action. No injunction, order, investigation, claim,
action or proceeding  before any court or governmental  body shall be pending or
threatened  wherein an  unfavorable  judgment,  decree or order would  restrain,
impair or prevent the carrying out of this Agreement or any of the  transactions
contemplated  hereby,  declare unlawful the transactions  contemplated hereby or
cause any such transaction to be rescinded.

                  4.3  Performance  of  Covenants.  All  of  the  covenants  and
agreements  of  the  Purchasers  contained  in  this  Agreement  required  to be
performed on or prior to the Closing Date shall have been  performed in a manner
satisfactory in all respects to the Company.

                  5.   Representations  and  Warranties  of  the  Company.   The
representations  and warranties of the Company  contained  herein are subject to
and qualified by the disclosures made in the Company's most recent Annual Report
on Form 10-K and  Quarterly  Report on Form  10-Q,  as filed  with the SEC.  The
Company hereby  represents and warrants to each Purchaser as of the Closing Date
as follows:

                  5.1.   Organization.   The  Company  is  a  corporation   duly
organized,  validly existing and in good standing under the laws of the State of
Delaware.  The Company is eligible  to be treated as a C  corporation  under the
Internal  Revenue  Code of 1986,  as amended (the  "Code").  The Company has all
requisite  corporate  power and authority,  and holds all licenses,  permits and
other  required  authorizations  from  governmental  authorities,  necessary  to
conduct its business as now being  conducted and to own or lease the  properties
and  assets  now owned or held  under  license  or lease.  The  Company  is duly
qualified  or licensed  and in good  standing as a foreign  corporation  in each
jurisdiction  wherein  the  character  of its  properties  or the  nature of the
activities  conducted by it makes such  qualification  or  licensing  necessary,
except where the failure to so qualify would not have a material  adverse effect
on the Company.

                  5.2. Charter Documents.  The Company has heretofore  delivered
to  Purchasers  true,   correct  and  complete  copies  of  the  Certificate  of
Incorporation  and  By-Laws  (or  comparable  organizational  documents)  of the
Company as in full force and effect on the date hereof.

                  5.3.  Capitalization.  As of December 10, 1999,  the Company's
authorized  capitalization  consists of 70,000,000  shares of Common  Stock,  of
which  43,655,709  shares are issued and outstanding,  and 10,000,000  shares of
preferred  stock, par value $.01 per share, of which 595.5 shares are designated
as  Series  F  Convertible  Preferred  Stock  and are  issued  and  outstanding.
15,022,288  shares of Common Stock are reserved for issuance upon the conversion
or exercise of  convertible  securities,  options,  warrants or other  rights to
purchase  Common  Stock  outstanding  as of the Closing  Date.  All  outstanding
securities  of the  Company are validly  issued,  fully paid and  nonassessable.
Except  for  the  rights  of  the  Series  F  Convertible  Preferred  Stock,  no
stockholder of the Company is entitled to any preemptive  rights with respect to
the purchase or sale of any securities by the Company.  There are no outstanding
options, warrants or other rights, commitments or arrangements, written or oral,
to purchase or otherwise  acquire any authorized but unissued  shares of capital
stock of the Company or any security directly or indirectly  convertible into or
exchangeable  for any  capital  stock of the  Company  or under  which  any such
option,  warrant or  convertible  security  may be issued in the  future  except
otherwise  as set  forth  on  Schedule  5.3.  There  are  no  voting  trusts  or
agreements,  stockholders'  agreements,  pledge agreements,  buy-sell, rights of

                                       4
<PAGE>

first offer,  negotiation or refusal or proxies or similar arrangements relating
to any  securities  of the Company to which the  Company is a party,  and to the
best  knowledge of the Company after due inquiry there are no other such trusts,
agreement,  rights,  proxies  or  similar  arrangements,  except as set forth on
Schedule 5.3.  Except as otherwise set forth on Schedule 5.3 or as  contemplated
by this  Agreement,  none of the  shares  of  capital  stock of the  Company  is
reserved for any purpose,  and the Company is neither  subject to any obligation
(contingent or otherwise), nor has any option to repurchase or otherwise acquire
or retire any shares of its capital stock.

                  5.4 Due Authorization,  Valid Issuance, Etc. The Common Shares
to be purchased on the Closing Date have been duly  authorized  and, when issued
in accordance with this Agreement upon the Closing Date, will be validly issued,
fully paid and non-assessable and will be free and clear of all liens imposed by
or through the  Company,  subject  only to  restrictions  set forth  herein,  as
applicable,  or applicable federal and state securities laws. The issuance, sale
and clear  delivery of such Common Shares will not be subject to any  preemptive
right of  stockholders  of the Company or to any right of first refusal or other
right in favor of any  person or entity  except for  provisions  which have been
waived in writing (and as to which the  Purchasers  have  received a copy of) or
satisfied and as set forth on Schedule 5.4. The Company's executive officers and
directors have studied and fully  understand the nature of the securities  being
sold hereunder, and recognize that they have a potential dilutive effect. Except
as set forth on Schedule 5.4, no  anti-dilution  adjustments with respect to the
outstanding  securities  of the Company will be triggered by the issuance of the
securities contemplated hereby.

                  5.5.  Subsidiaries.  Except  as  otherwise  disclosed  in  the
Company's  Annual  Report on Form 10-K for the year  ended  June 30,  1999,  the
Company has no wholly or  partially  owned  Subsidiaries  (as defined in Section
9.9) and does not  control,  directly  or  indirectly,  any  other  corporation,
business  trust,  firm,  partnership,  association,  joint  venture,  entity  or
organization.  Except as otherwise  disclosed in the Company's  Annual Report on
Form 10-K for the year ended June 30, 1999,  the Company does not own any shares
of stock,  partnership  interest,  joint venture interest or any other security,
equity or interest in any other corporation or other Person.

                  5.6.  Authorization;  No  Breach.  The  Company  has the  full
corporate power and authority to execute,  deliver and enter into this Agreement
and to perform  its  obligations  hereunder,  and the  execution,  delivery  and
performance of this  Agreement and all other  transactions  contemplated  hereby
have been duly  authorized by the Company.  This Agreement  constitutes a legal,
valid and binding obligation of the Company,  enforceable in accordance with its
terms  except  as  such   enforceability  may  be  limited  by  (a)  bankruptcy,
insolvency,  moratorium and similar laws affecting  creditors'  rights generally
and (b) the availability of remedies under general equitable principles.  Except

                                       5
<PAGE>

as set forth on Schedule  5.6, the execution and delivery by the Company of this
Agreement,  the  offering,  sale and  issuance  of the  Common  Shares,  and the
performance and fulfillment by the Company of its obligations hereunder,  do not
and will not (i) conflict with or result in a breach of the terms, conditions or
provisions of, (ii) constitute a default under,  or event which,  with notice or
lapse of time or both,  would  constitute  a breach of or default  under,  (iii)
result in the creation of any lien, security interest,  adverse claim, charge or
encumbrance  upon the capital  stock or assets of the Company  pursuant to, (iv)
give any third party the right to accelerate any obligation  under or terminate,
(v)  result  in a  violation  of,  (vi)  result  in the  loss  of  any  license,
certificate,  legal privilege or legal right enjoyed or possessed by the Company
under,  or (vii) with the  exception of an  application  to NASDAQ,  require any
authorization,  consent, approval, exemption or other action by or notice to any
court or  administrative or governmental body pursuant to or require the consent
of any other Person under,  the Certificate of  Incorporation  or By-Laws of the
Company or any law, statute,  rule or regulation to which the Company is subject
or by which any of its  properties  are  bound,  or any  agreement,  instrument,
order,  judgment  or decree  to which the  Company  is  subject  or by which its
properties  are  bound,  except,  in all  instances,  for  matters  which do not
materially adversely affect the Company's business,  financial condition, result
of operations or prospects ("Material Adverse Effect").

                  5.7. No Material  Adverse  Changes.  Since September 30, 1999,
except as  disclosed on Schedule 5.7 there has not at any time been any material
adverse change in the business, financial condition, operating results, business
prospects,  employee relations or customer  relations of the Company.  Except as
set forth on Schedule 5.7, no event or circumstance  has occurred or exists with
respect to the Company or its  business,  properties,  prospects,  operations or
financial condition,  which, under applicable law, rule or regulation,  requires
public  disclosure  or  announcement  by the  Company  but which has not been so
publicly announced or disclosed.

                  5.8. Absence of Certain  Developments.  Except as contemplated
by this Agreement,  and except as set forth on Schedule 5.8, since September 30,
1999 the Company has not,  nor will have prior to the Closing  Date:  (a) issued
any  securities  (other than as permitted or  contemplated  by this Agreement or
securities issued subsequent to December 10, 1999 upon conversion of outstanding
securities or options); (b) borrowed any amount or incurred or became subject to
any liabilities  (absolute or contingent)  which involve $50,000 or more,  other
than  liabilities  incurred in the ordinary  course of business and  liabilities
under contracts entered into in the ordinary course of business;  (c) discharged
or satisfied any lien,  adverse claim or  encumbrance  or paid any obligation or
liability  (absolute or contingent),  other than current liabilities paid in the
ordinary course of business; (d) declared or made any payment or distribution of
cash or other  property to the  stockholders  of the Company with respect to the
Common Stock or purchased or redeemed any shares of Common Stock; (e) mortgaged,
pledged  or  subjected  to  any  lien,  adverse  claim,   charge  or  any  other
encumbrance, any of its properties or assets, except for liens for taxes not yet
due and payable and  transactions in the ordinary course of business;  (f) sold,
assigned or transferred any of its assets, tangible or intangible, except in the
ordinary  course of business or in an amount less than $50,000,  or disclosed to
any person, firm or entity not subject to a confidentiality  obligation with the
Company any proprietary confidential information; (g) suffered any extraordinary
losses or waived any rights of material value; (h) made any capital expenditures
or commitments therefor greater than $50,000 in the aggregate;  (i) entered into
any other  transaction  other than in the ordinary course of business;  (j) made
any charitable  contributions or pledges;  (k) suffered damages,  destruction or
casualty  loss,  whether  or not  covered  by  insurance,  affecting  any of the

                                       6
<PAGE>
properties  or assets of the  Company or any other  properties  or assets of the
Company which could have a material  adverse  effect on the business,  financial
condition, operating results, employee or customer relations or prospects of the
Company;  (l) made any  material  change  in the  nature  or  operations  of the
business of the Company;  or (m)  resolved to or entered  into any  agreement or
understanding with respect to any of the foregoing.

                  5.9. Properties.  The Company has good and marketable title to
all of the real  property  and good title to all of the  personal  property  and
assets it purports to own as set forth in the Financial Statements, whether such
property  is real or  personal,  free and clear of all  liens,  adverse  claims,
charges,  encumbrances or restrictions of any nature whatsoever, except (a) such
as are reflected on Schedule 5.9 or in the notes to the Financial  Statements in
the Company's  Annual Report on Form 10-K for the year ended June 30, 1999,  (b)
for  receivables and charges  collected in the ordinary course of business,  (c)
liens  with  respect  to taxes not yet due and (d)  immaterial  exceptions  of a
routine and customary  nature.  Except as disclosed in Schedule 5.9, the Company
owns or leases all such  properties  as are  necessary to its  operations as now
conducted and as presently proposed to be conducted and all such properties are,
in all material respects, in good operating condition and repair.

                  5.10. Taxes. Except as set forth on Schedule 5.10, the Company
has timely filed all federal,  state,  local and foreign tax returns and reports
required to be filed, and all taxes, fees,  assessments and governmental charges
of any nature  shown by such returns and reports to be due and payable have been
timely paid except for those amounts being contested in good faith and for which
appropriate  amounts have been reserved in accordance  with  generally  accepted
accounting principles. There is no tax deficiency that has been, or, to the best
knowledge of the Company after due inquiry may reasonably be,  asserted  against
the Company that would  materially  adversely affect the business or operations,
or proposed  business or  operations,  of the Company.  All such tax returns and
reports were prepared in accordance  with the relevant rules and  regulations of
each  taxing  authority  having  jurisdiction  over the Company and are true and
correct  in all  material  respects.  The  Company  has  neither  given nor been
requested  to give any waiver of any  statute  of  limitations  relating  to the
payment of federal,  state,  local or foreign  taxes.  The Company has not been,
nor, to its knowledge,  is it now being, audited by any federal, state, local or
foreign tax  authorities.  The Company has made all required  deposits for taxes
applicable  to the current tax year.  The Company is not,  and has never been, a
member of any "affiliated group" within the meaning of Section 1504 of the Code,
as in effect from time to time.

                  5.11. Litigation.  Except as set forth on Schedule 5.11, there
are no actions, suits, proceedings, orders, investigations or claims pending or,
to the best  knowledge of the Company after due inquiry,  threatened  against or
affecting the Company,  at law or in equity or before or by any federal,  state,
municipal or other governmental department, commission, board, bureau, agency or
instrumentality;  there are no arbitration  proceedings pending under collective
bargaining agreements or otherwise.

                  5.12.  Compliance  with Law.  The Company has  complied in all
material  respects with all  applicable  statutes and  regulations of the United
States and of all states,  municipalities  and  applicable  agencies and foreign
jurisdictions  or  bodies  in  respect  of  the  conduct  of  its  business  and
operations.

                                       7
<PAGE>

                  5.13.  Trademarks and Patents.  Schedule 5.13 contains a true,
complete and correct list of all registered,  certificated or issued trademarks,
trade names, patents and copyrights (and applications  therefor),  if any, owned
or (to the extent evidenced by contract or license  agreement)  licensed or used
or  required  to be used by the  Company as of or prior to the  Closing  Date in
connection  with its business and,  except as set forth on Schedule  5.13,  each
such  trademark,  trade name,  patent and copyright (and  application  therefor)
listed in  Schedule  5.13 as being  owned by the  Company is not  subject to any
license,  royalty  arrangement,  option or dispute  and is free and clear of all
material liens. To the best knowledge of the Company after due inquiry,  none of
the  trademarks,  trade  names,  patents or  copyrights  used by the  Company in
connection  with its business  infringes any  trademark,  trade name,  patent or
copyright  of others in the United  States or in any other  country,  in any way
which materially  adversely  affects or which in the future is reasonable likely
to materially adversely affect the business or operations of the Company. Except
as set forth on Schedule 5.13 or in the Company's Annual Report on Form 10-K for
the year ended June 30, 1999, no stockholder, officer or director of the Company
or any other  person  owns or has any  interest  in any  trademark,  trade name,
service  mark,  patent,  copyright or  application  therefor,  or trade  secret,
licenses,  invention,  information or proprietary right or process, if any, used
by the Company in  connection  with its  business.  The Company has no notice or
knowledge of any objection or claim being asserted by any person with respect to
the ownership,  validity,  enforceability  or use of any such trademarks,  trade
names,  patents and copyrights (and  applications  therefor)  listed on Schedule
5.13 or challenging or questioning the validity or  effectiveness of any license
relating thereto.  There are no unresolved conflicts with, or pending claims of,
any other person, whether in litigation or otherwise,  involving the trademarks,
trade names, patents and copyrights (and applications  therefor),  and there are
no liens,  encumbrances,  adverse  claims,  or rights of any other  person which
would prevent the Company from fulfilling its  obligations  under this Agreement
except in all cases which would not have a Material Adverse Effect.  To the best
knowledge  of the Company  after due inquiry,  the  business of the Company,  as
presently  conducted does not cause the Company to violate any trademark,  trade
name, patent,  copyright,  trade secret,  license or proprietary interest of any
other  person or  entity,  in any way which  materially  adversely  affects  the
business or operations of the Company. Except as disclosed in Schedule 5.13, the
Company  possesses all proprietary  technology  necessary for the conduct of its
business.

                  5.14.  Insurance.  Each of the Company's insurance policies is
in full force and  effect;  and the  Company  is not in default in any  material
respect with respect to its  obligations  under any of such insurance  policies.
Such insurance coverage is in amounts not less than is customarily maintained by
corporations  engaged in the same or similar  business and  similarly  situated,
including,  without  limitation,  insurance against loss,  damage,  fire, theft,
public  liability and other risks.  The activities and operations of the Company
have been conducted in a manner so as to conform to all applicable provisions of
these  insurance  policies  and the  Company has not taken or failed to take any
action which would cause any such insurance policy to lapse.

                  5.15.  Agreements.  Except as set forth on Schedule 5.15 or as
disclosed  in the  Company's  proxy  statement  for its 1999  annual  meeting of
stockholders  or as filed on the  Company's  most recent  Annual  Report on Form
10-K,  the  Company is not party to nor bound by any  agreement  or  commitment,
written or oral, which obligates the Company to make payments to any person,  or
which obligates any person to make payments to the Company,  in the case of each
such agreement in an amount exceeding $60,000, or which is otherwise material to
the  conduct  and  operation  of  the  business  of  the  Company  or any of its

                                       8
<PAGE>

properties  or  assets,   including,   without   limitation,   all  shareholder,
employment, non-competition and consulting agreements and employee benefit plans
and arrangements and collective  bargaining agreements to which the Company is a
party  or by  which  it  is  bound.  The  Company  has  performed  all  material
obligations required to be performed by it, and is not in default, or in receipt
of any claim,  under any such  agreement or  commitment,  and the Company has no
present   expectation  or  intention  of  not  fully   performing  all  of  such
obligations,  nor  does  the  Company  have  any  knowledge  of  any  breach  or
anticipated  breach by the other  parties to any such  agreement or  commitment.
Each  Purchaser has been  furnished  with, or the Company has made available for
such  Purchaser's  review,  a true and correct  copy of each  written  agreement
referred to in Schedule  5.15,  together with all  amendments,  waivers or other
changes thereto.

                  5.16. Undisclosed Liabilities. Except to the extent reflected,
disclosed or reserved  against in the Financial  Statements or the notes thereto
and except for  liabilities  incurred  since  September 30, 1999 in the ordinary
course  and  consistent  with  past  practice,  the  Company  does  not have any
obligation  or liability  whether  absolute,  accrued,  contingent or otherwise,
which is material to the business,  operations, assets or financial condition of
the Company.

                  5.17. Employees;  Conflicting Agreements.  (a) The Company has
caused all present members of management and all  professional  employees of and
consultants and advisors to the Company, including all employees and consultants
and  advisors  involved in  research  and  development,  and will cause all such
persons  in  the  future,  to be  subject  to  agreements  with  respect  to (i)
nondisclosure   of  confidential   information,   (ii)  assignment  of  patents,
trademarks,   copyrights  and  proprietary  rights  to  the  Company  and  (iii)
disclosure to the Company of inventions.

                  (b) To the best knowledge of the Company after due inquiry, no
stockholder,  director,  officer or key employee of the Company is a party to or
bound by any agreement,  contract or commitment,  or subject to any restrictions
in connection with any previous or current  employment of any such person (other
than as set forth on  Schedule  5.17(b)  with  respect  to the  Company),  which
materially  adversely affects,  or which in the future may materially  adversely
affect,  the business or the  proposed  business of the Company or the rights of
any of the Purchasers under this Agreement.

                  5.18.  Disclosure.  Neither  this  Agreement  nor  any  of the
schedules,  exhibits, written statements,  documents or certificates prepared or
supplied by the Company with respect to the  transactions  contemplated  by this
Agreement  contain any untrue  statement  of a material  fact or omit a material
fact necessary to make the statements  contained therein not misleading in light
of the  circumstances  under which made.  Except for  general  factors  that are
common in the market and industry of the Company and such other information made
available to the Purchasers and their  representatives,  there exists no fact or
circumstance  which,  to the best  knowledge  of the Company  after due inquiry,
materially adversely affects, or which could reasonably be anticipated to have a
material  adverse  effect on, the  existing  or  expected  financial  condition,
operating results,  assets,  customer relations,  employee relations or business
prospects of the Company.

                                       9
<PAGE>

                  5.19.  Compliance  with  Securities  Laws.  (a)  Assuming  the
accuracy and truth of each of Purchasers'  representations  set forth in Section
6, all  securities  of the  Company  heretofore  sold and  issued  were sold and
issued,  and the Common  Shares were  offered  and will be sold and  issued,  in
compliance  with all  applicable  federal,  state and foreign  securities  laws.
Neither the Company, nor any of its Affiliates, nor, to its best knowledge after
due inquiry, any person or entity acting on its or their behalf has, directly or
indirectly,  made any offers or sales of any security or solicited any offers to
buy any security,  under  circumstances  that would require  registration of the
Common  Shares under the  Securities  Act of 1933,  as amended (the  "Securities
Act") or for the offering of the same to be integrated  with any other  offering
of securities.

                  (b) The Company has not  directly or  indirectly  purchased or
redeemed  any shares of Common Stock  during the 30 days  preceding  the Closing
Date.

                  5.20.  Brokers.  Except  as set  forth on  Schedule  5.20,  no
finder,  broker,  agent,  financial  person or other  intermediary  has acted on
behalf of the Company in connection with the offering of the Common Shares,  the
execution  of the  Agreement  or  the  consummation  of any of the  transactions
contemplated hereby.

                  5.21.  Transactions  with  Affiliates.  Except as set forth on
Schedule 5.21 or in the Company's proxy statement for its 1999 annual meeting of
stockholders,  no  director,  officer,  employee,  consultant  or  agent  of the
Company,  or  member  of the  family  of any  such  person  or any  corporation,
partnership,  trust or other entity in which any such  person,  or any member of
the family of any such person,  has a substantial  interest in or is an officer,
director,  trustee, partner or holder of more than 5% of the outstanding capital
stock thereof,  is a party to any  transaction  with the Company,  including any
contract,  agreement  or other  arrangement  providing  for the  employment  of,
furnishing of services by or requiring payments to any such person or firm.

                  5.22.   Environmental   Matters.  (a)  The  Company,  and  all
properties owned, operated or leased by the Company, have obtained and currently
maintain  all material  environmental  permits  required for their  business and
operations and are in compliance with all such environmental  permits. There are
no legal proceedings pending nor, to the best knowledge of the Company after due
inquiry,  threatened  to modify or revoke any such  environmental  permits.  The
Company  has not  received  any notice from any source that there is lacking any
environmental  permit  required for the current use or operation of the business
of the Company, or any property owned, operated or leased by the Company.

                  (b) Except as set forth on Schedule  5.22,  all real  property
owned,  operated or leased by the  Company,  and, to the best  knowledge  of the
Company after due inquiry,  all property  adjacent to such properties,  are free
from  contamination by any hazardous  material other than any such contamination
as would not have a Material  Adverse Effect;  and the Company is not subject to
environmental costs and liabilities with respect to hazardous materials,  and no
facts or circumstances  exist which could give rise to  environmental  costs and
liabilities with respect to hazardous materials.

                                       10
<PAGE>

                  (c) Except as set forth on  Schedule  5.22,  there is not now,
nor, to the best  knowledge of the Company after due inquiry,  has there been in
the past, on, in, or under any real property owned,  leased,  or operated by the
Company, or by any of their respective  predecessors (i) any asbestos-containing
materials, (ii) any underground storage tanks, (iii) above-ground storage tanks,
(iv)   impoundments,   (v)   poly-chlorinated   biphenyls  or  (vi)  radioactive
substances.

                  (d) The Company, and all properties owned,  operated or leased
by the Company, comply with all environmental laws.

                  (e) Since June 30, 1998, neither the Company, nor any property
owned,  leased or  operated  by the  Company,  has  received  or been issued any
written request for  information,  or has been notified that it is a potentially
responsible  party under the  environmental  laws with respect to any on-site or
off-site for which environmental costs and liabilities are asserted.

                  6.  Representations,  Warranties  and Covenants of Purchasers.
Purchasers  severally  represent,  warrant and covenant to the Company as of the
Closing Date as follows:

                   6.1.  Investment  Intent.  Each  Purchaser is an  "accredited
investor"  within the meaning of  Regulation D under the  Securities  Act.  Each
Purchaser  has   experience  in  making   investments   in   development   stage
biotechnology  companies  and is acquiring the Common Shares for its own account
and not with a present view to, or for sale in connection with, any distribution
thereof in violation of the  registration  requirements  of the Securities  Act.
Each  Purchaser  consents  to  the  placing  of a  legend  on  the  certificates
representing its respective Common Shares to the effect that, and each Purchaser
acknowledges  that,  such  Common  Shares  have not been  registered  under  the
Securities Act and may not be transferred  unless  registered in accordance with
applicable securities laws or, in the opinion of counsel to the Purchasers (such
opinion to be in form and  substance  reasonably  satisfactory  to the Company),
exempt therefrom.

                  6.2. Authorization. Each Purchaser has the power and authority
to execute and deliver this Agreement and to perform its obligations  hereunder,
having obtained all required consents, if any, and this Agreement, when executed
and  delivered,  will  constitute a legal valid and binding  obligation  of such
Purchaser  except  as such  enforceability  may be  limited  by (a)  bankruptcy,
insolvency,  moratorium and similar laws affecting  creditors'  rights generally
and (b) the availability of remedies under general equitable principles.

                  6.3. Brokers. No finder,  broker,  agent,  financial person or
other  intermediary has acted on behalf of the Purchasers in connection with the
offering of the Common Shares or the  consummation  of this  Agreement or any of
the transactions contemplated hereby.

                  6.4.  No Short.  For a period of six months  from the  Closing
Date, the Purchasers will not "short" or "short against the box" (as those terms
are generally understood) any equity security of the Company; provided, however,
that if the Shelf Registration  Statement (as defined below) is not effective by
the date that is 60 days following the Closing Date,  then the Purchasers  shall
have no  obligation  under  this  section  6.4  until  such  time  as the  Shelf
Registration Statement is declared effective by the SEC.

                                       11
<PAGE>

                  7. Covenants of the Company. Until such time as (a) Purchasers
and their Affiliates  beneficially own less than five percent (5%) of the Common
Stock then  outstanding,  the Company  covenants  and agrees with  Purchasers as
follows:

                  7.1.  Books and Accounts.  The Company will: (a) make and keep
books, records and accounts,  which, in reasonable detail, accurately and fairly
reflect its  transactions,  including  without  limitation,  dispositions of its
assets;  and (b) devise and  maintain a system of internal  accounting  controls
sufficient to provide  reasonable  assurances that (i) transactions are executed
in  accordance  with  management's  general  or  specific  authorization,   (ii)
transactions  are  recorded as  necessary  to permit  preparation  of  financial
statements in conformity with generally  accepted  accounting  principles and in
accordance with the Company's past practices or any other criteria applicable to
such  statements,  and to maintain  accountability  for assets,  (iii) access to
assets is permitted  only in accordance  with  management's  general or specific
authorization,  and (iv) the recorded accountability for assets is compared with
the existing assets at reasonable intervals and appropriate action is taken with
respect to any differences.

                  7.2.  Periodic  Reports.  The  Company  will  furnish  to  the
Purchasers, other than documents available via EDGAR: (i) as soon as practicable
(but in the case of the annual report of the Company to its stockholders, within
ninety (90) days after the end of each fiscal year of the  Company) one copy of:
(A) its annual  report to its  stockholders  (which  annual report shall contain
financial  statements audited in accordance with generally  accepted  accounting
principles  in the  United  States  of  America  by a firm of  certified  public
accountants  of  recognized  standing),  (B) if not included in substance in its
annual report to  stockholders,  its annual report on Form 10-K, (C) each of its
quarterly reports to its  stockholders,  and if not included in substance in its
quarterly  reports to stockholders,  its quarterly report on Form 10-Q, (D) each
of its  current  reports  on  Form  8-K,  and  (E) a  copy  of  the  full  Shelf
Registration  Statement  (as  defined  below),  (the  foregoing,  in each  case,
excluding exhibits);  and (ii) upon reasonable request, all exhibits excluded by
the parenthetical to the immediately preceding clause 7.2(a)(i)(E) and any other
information published by the Company that is generally available to the public.

                  7.3. Other Reports and Inspection. The Company will furnish to
the  Purchasers,  other  than  documents  available  via  EDGAR:  (a) as soon as
practicable  after  issuance,  copies of any  financial  statements  or  reports
prepared by the Company for, or otherwise  furnished to, its stockholders or the
SEC  (other  than  information  furnished  to  the  SEC  on  a  confidential  or
supplemental  basis)  and  (b)  promptly,  such  other  documents,  reports  and
financial  data  as  Purchasers  may  reasonably  request,   provided  that  the
Purchasers  agree to preserve  the  confidential  nature of, and to refrain from
trading on the basis of, material  requested by the Purchasers which the Company
has marked as confidential.  In addition the Company will, upon reasonable prior
notice, make available to Purchasers or its representatives or designees (x) all
assets,  properties  and  non-confidential  business  records of the Company for
inspection  and (y) the  directors  and  officers of the Company for  interviews
concerning the business, affairs and finances of the Company.

                                       12
<PAGE>

                  7.4.  Insurance.  The Company will at all times maintain valid
policies  of  worker's  compensation  insurance  and such other  insurance  with
respect to its properties and business of the kinds and in amounts not less than
is  customarily  maintained  by  corporations  engaged  in the  same or  similar
business  and  similarly  situated,  including,  without  limitation,  insurance
against  fire,  loss,  damage,  theft,  public  liability  and other risks.  The
activities  and  operations  of the Company  shall be  conducted  in a manner to
conform in all material respects to all applicable provisions of such policies.

                  7.5. Use of Proceeds.  The Company  shall use the net proceeds
from the sale of the Common Shares for the redemption of all outstanding  shares
of its  Series F  Convertible  Preferred  Stock at a price  equal to 109% of the
stated value of such Series F  Convertible  Preferred  Stock (which is $10,000).
Any  net  proceeds  exceeding  the  amount  required  to  redeem  the  Series  F
Convertible Preferred Stock shall be used for general corporate purposes.

                  7.6.  Transactions with Affiliates.  Except for employment and
consulting agreements entered into in the ordinary course of business (including
such  agreements  in  effect  as of  the  Closing  Date)  and  the  transactions
contemplated  by  this  Agreement,  the  Company  shall  not (a)  engage  in any
transaction  with,  (b) make any loans  to,  nor (c)  enter  into any  contract,
agreement or other  arrangement (i) providing for (x) the employment of, (y) the
furnishing of services by (other than  employment and consulting  services),  or
(z) the rental of real or personal  property from, or (ii)  otherwise  requiring
payments  to,  any  officer,  director  or key  employee  of the  Company or any
relative of such persons or any other "associate" of such persons (as such terms
are defined in the rules and regulations  promulgated under the Securities Act),
without the prior written  approval of the Purchasers,  which approval shall not
be unreasonably withheld.

                  7.7. Corporate Existence, Licenses and Permits; Maintenance of
Properties;  New Businesses.  The Company will at all times conduct its business
in the  ordinary  course  and will use its best  efforts to cause to be done all
things necessary to maintain,  preserve and renew its existence and will use its
best efforts to preserve and keep in force and effect, all licenses, permits and
authorizations  necessary to the conduct of its business.  The Company will also
maintain and keep its  properties in good repair,  working order and  condition,
and from time to time,  to make all needful  and proper  repairs,  renewals  and
replacements,  so that the business  carried on in  connection  therewith may be
properly conducted at all times.

                  7.8. Other Material Obligations. The Company will use its best
efforts to comply in all material  respects with,  (a) all material  obligations
which it is subject  to, or becomes  subject  to,  pursuant  to any  contract or
agreement,  whether  oral or written,  as such  obligations  are  required to be
observed  or  performed,  unless  and to the  extent  that the  same  are  being
contested in good faith and by appropriate  proceedings  and the Company has set
aside  on its  books  adequate  reserves  with  respect  thereto,  and  (b)  all
applicable laws,  rules, and regulations of all  governmental  authorities,  the
violation  of which  could have a material  adverse  effect  upon the  business,
financial  condition,  operating  results,  employee  or customer  relations  or
prospects of the Company.

                                       13
<PAGE>

                  7.9.  Amendment to the  Certificate of  Incorporation  and the
By-Laws.  The Company will perform and be in compliance  with and observe all of
the provisions set forth in its Certificate of Incorporation  and By-Laws to the
extent that the performance of such obligations is legally permissible; provided
that the fact that performance is not legally  permissible will not prevent such
nonperformance  from  constituting  an event of default  under  this  Agreement.
Except  with  the  consent  of  the  Purchasers,  which  consent  shall  not  be
unreasonably   withheld,   the  Company  will  not  amend  its   Certificate  of
Incorporation  or By-Laws or any Certificate of  Designations  for any series of
Preferred  Stock  of  the  Company  so as to  affect  adversely  the  rights  of
Purchasers  under  this  Agreement,  the  Certificate  of  Incorporation  or the
By-Laws.

                  7.10.  Consents  and  Waivers.  The Company has  obtained  all
consents and waivers needed to enable it to perform all of its obligations under
this Agreement and the transactions contemplated hereby.

                  7.11.  Taxes  and  Liens.  The  Company  shall  duly  pay  and
discharge when payable, all taxes,  assessments and governmental charges imposed
upon or against the Company or its  properties,  or any part thereof or upon the
income or profits therefrom,  in each case before the same become delinquent and
before penalties accrue thereon,  as well as all claims for labor,  materials or
supplies  which if unpaid  might by law become a lien upon any of its  property,
unless and to the extent that the same are being  contested in good faith and by
appropriate  proceedings  and the  Company  has set aside on its books  adequate
reserves with respect thereto.

                  7.12. Restrictive Agreement.  The Company covenants and agrees
that  subsequent  to the  Closing,  it shall not be a party to any  agreement or
instrument  which by its terms would  restrict the Company's  performance of its
obligations  pursuant to this  Agreement,  the Certificate of  Incorporation  or
By-laws of the Company or the Common Shares.

                  7.13. Publicity. The Company shall not issue any press release
or make any other  public  announcement  with  respect to this  Agreement or the
transactions  contemplated  hereby or utilizing the names of Purchasers or their
officers, directors, employees, agents or Affiliates without obtaining the prior
approval of Purchasers,  except as may be required by law or the  regulations of
any securities exchange.

                  7.14.  Restriction  on  Securities.  (a) During  the  12-month
period  following the Closing Date,  the Company will not extend the  expiration
date or lower the exercise price of any options or warrants, or take any similar
action with respect to any convertible securities of the Company.

                  (b) Prior to the Closing  Date,  the Company  shall obtain the
written agreement of all executive  officers and directors of the Company to (i)
"lock-up"  all of the shares of Common  Stock  owned by each of them at any time
until  (1)  the  date on  which  all  Common  Shares  may be  sold  in a  single
transaction  on a  registered  securities  exchange or national  market under an
applicable  exemption from the  registration  requirements of the Securities Act
and all other  applicable  securities  laws and (2) the date that is six  months

                                       14
<PAGE>

following the Closing Date;  provided that the executive  officers and directors
of the Company may sell an aggregate of one million (1,000,000) shares of Common
Stock in such 6-month period so long as any such  executive  officer or director
provide to the Purchasers a written notice of their intent to sell at least five
(5) days prior to the earlier of (A) the filing of a Form 144 by such person and
(B) the date of such proposed sale, (ii) not directly or indirectly sell "short"
or "short against the box" (as those terms are generally understood),  until the
date that is 6 months following the Closing Date.

                  7.15.  Restriction  on Liens.  The Company shall not create or
permit  the  imposition  of any  liens on any of its  assets  from and after the
Closing Date without the prior written authorization of the Board of Directors.

                  7.16. Restrictions on Indebtedness. Without the prior approval
of the Board of Directors, the Company shall not incur, create, assume or permit
to exist any indebtedness except (i) pursuant to equipment lease financings with
commercial  banks or Persons  whose  business  consists in  substantial  part of
engaging in such financings,  (ii) pursuant to customary accounts receivable and
inventory financing in the ordinary course of business,  (iii) in an amount less
than $100,000 incurred in the ordinary course of business, and (iv) indebtedness
for borrowed  money  existing on the date hereof and disclosed in writing to the
Purchasers,   but  not  any   extensions,   renewals  or  replacements  of  such
indebtedness.

                  7.17.  Board of Directors.  (a) The Company shall at all times
maintain   provisions  in  its  By-laws  and/or   Certificate  of  Incorporation
indemnifying  all directors  against  liability and absolving all directors from
liability to the Company and its  stockholders  to the maximum extent  permitted
under the laws of the State of Delaware.

                  (b) The By-laws of the Company shall always contain provisions
consistent  with the  provisions  of this Section 7.17 except to the extent this
Section 7.17 deals with the possible observer.

                  7.18.   Certain   Subsidiaries.   Except  for   wholly   owned
subsidiaries of the Company.,  the Company will not create any entity that would
be a Subsidiary (as defined in Section 9.9) without the prior written consent of
the  Purchasers.  Notwithstanding  the  foregoing,  the  Company may acquire any
interest in any business from any person,  firm or entity (whether by a purchase
of assets,  purchase of stock,  merger or otherwise) using cash or stock without
the prior written consent of the Purchasers.

                  7.19.  Listing.  The  Company  will take all action  necessary
promptly to file an  Application  for Listing of  Additional  Shares with Nasdaq
National  Market  and/or  take any other  necessary  action to enable the Common
Stock to trade on a national market.

                  7.20.  Material Changes.  The Company will promptly notify the
Purchasers  of  any  material  adverse  change  in  its  business  or  financial
condition.

                  7.21.  Adjustment  to Per Share Price.  If,  commencing on the
date that is six months from the Closing Date and ending on the date that is one
year from the  Closing  Date,  the Company  issues  shares of Common  Stock,  or
securities  convertible  into or  exercisable  for shares of Common Stock,  at a

                                       15
<PAGE>

price  per  share  less  than  the Per  Share  Price,  then  the  Company  shall
simultaneously issue to the Purchasers for no additional consideration, a number
of shares of Common  Stock  sufficient  to reduce  the Per Share  Price  then in
effect to equal the "Adjusted  Price" (as defined  below).  For purposes of this
section  7.21(b),  the term Adjusted  Price (which shall not be greater than the
Per Share Price then in effect)  shall equal a fraction,  the numerator of which
shall equal (1) the sum of (A) the number of shares of Common Stock  outstanding
on the record date of such  issuance or sale  multiplied  by the Per Share Price
then in effect  plus (B) the Total  Consideration  (as defined  below),  and the
denominator  of which shall be the number of shares of Common Stock  outstanding
on the  record  date of such  issuance  or  sale  plus  the  maximum  number  of
additional  shares of Common Stock  issued,  sold or issuable  upon  exercise or
conversion  of such  securities.  "Total  Consideration"  shall  mean the  total
amount,  if any,  received or receivable by the Company in  consideration of the
issuance  or sale of such  securities  plus  the  total  consideration,  if any,
payable to the Company upon  exercise  thereof.  The  provisions of this section
7.21(b)  shall  not  apply  (i) to  issuances  of  securities  in any  corporate
partnering  arrangements (including mergers) consummated by the Company, (ii) to
the exercise or conversion of options,  warrants or other convertible securities
outstanding  as of the  Closing  Date,  or  (iii)  to  issuances  which,  in the
aggregate, yield gross proceeds to the Company of less than $250,000.

                  7.22. Right of First Refusal. In the event that, within the 12
month  period  following  the Closing  Date,  the  Company  intends to conduct a
private placement of its securities through a placement agent,  broker-dealer or
finder, pursuant to which it will pay such agent a commission,  then the Company
shall (a) notify Paramount Capital, Inc. ("Paramount") of such intent in writing
detailing the terms of such proposed  offering and (b) grant Paramount the right
of first  refusal to act as  placement  agent for the  Company  in such  private
placement.  Paramount shall notify the Company within 15 days of its intent.  In
the event that Paramount  declines to act as placement  agent for the Company on
the terms  proposed  to  Paramount  in the notice and the  Company  subsequently
offers to a third-party  the opportunity to act as placement agent on terms more
favorable  than those  offered to  Paramount,  then the Company must first offer
such opportunity to Paramount on such more favorable terms.

         8.       Registration of Common Stock.

         8.1.  Registration.  (i) Not later than 30 days after the Closing Date,
the Company will file with the SEC a shelf  registration  statement  (the "Shelf
Registration  Statement")  with  respect  to the  resale  of the  Common  Shares
beneficially  owned  by  Purchasers  following  the  Closing  (the  "Registrable
Securities"). The Company will use its best efforts to effect the registrations,
qualifications or compliances (including,  without limitation,  the execution of
any  required  undertaking  to  file  post-effective   amendments,   appropriate
qualifications  under  applicable  blue sky or other state  securities  laws and
appropriate   compliance  with  applicable  securities  laws,   requirements  or
regulations)  as may be  reasonably  requested and as would permit or facilitate
that sale and distribution of all Registrable  Securities until the distribution
thereof  is  complete;  provided  that the  Company  shall not be  obligated  to
maintain the effectiveness of the Shelf Registration  Statement (and any related
qualifications and compliance)  following such time as the Company shall deliver
an opinion of counsel  reasonably  satisfactory  to the  holders of  Registrable
Securities (the "Holders') and in form and substance satisfactory to each Holder

                                       16
<PAGE>

that  (i)  such  Holders  may  sell  in a  single  transaction  all  Registrable
Securities  then held or  issuable  to such  Holder on a  registered  securities
exchange or Nasdaq market under an applicable  exemption  from the  registration
requirements of the Securities Act and all other applicable  securities laws and
(ii) all  transfer  restrictions  and  restrictive  legends with respect to such
Registrable Securities will be removed upon the consummation of such sale.

                  8.2.   Registration   Procedures.   In  connection   with  the
registration of any Registrable  Securities under the Securities Act as provided
in this Section 8, the Company will use its best efforts,  as  expeditiously  as
possible to:

                  (a)  Prepare  and  file  with the SEC the  Shelf  Registration
Statement with respect to such  Registrable  Securities and use its best efforts
to cause such Shelf Registration  Statement to become effective as expeditiously
as possible;

                  (b)  Prepare  and  file  with  the  SEC  such  amendments  and
supplements  to such Shelf  Registration  Statement and the  prospectus  used in
connection  therewith  as may be  necessary  to  keep  such  Shelf  Registration
Statement  effective  until the disposition of all securities in accordance with
the intended  methods of disposition by the seller or sellers  thereof set forth
in such Shelf Registration Statement shall be completed,  and to comply with the
provisions of the Securities Act (to the extent  applicable to the Company) with
respect to such dispositions;

                  (c) Furnish to each seller of such Registrable Securities such
number of copies of such Shelf Registration Statement and of each such amendment
and supplement  thereto (in each case  including all  exhibits),  such number of
copies  of  the  prospectus  included  in  such  Shelf  Registration   Statement
(including each preliminary prospectus),  in conformity with the requirements of
the  Securities  Act, and such other  documents,  as such seller may  reasonably
request,  in order to facilitate the disposition of the  Registrable  Securities
owned by such seller;

                  (d)  Use  its  best   efforts  to  register  or  qualify  such
Registrable  Securities covered by such Shelf Registration  Statement under such
other securities or blue sky laws of such jurisdictions as any seller reasonably
requests,  and do any and all other  acts and  things  which  may be  reasonably
necessary or advisable to enable such seller to consummate  the  disposition  in
such  jurisdictions of the Registrable  Securities owned by such seller,  except
that the Company will not for any such purpose be required to qualify  generally
to do business as a foreign  corporation  in any  jurisdiction  wherein it would
not,  but for the  requirements  of  this  Section  8.2(d)  be  obligated  to be
qualified, to subject itself to taxation in any such jurisdiction, or to consent
to general service of process in any such jurisdiction;

                  (e)  Provide  a  transfer  agent  and  registrar  for all such
Registrable  Securities covered by such Shelf  Registration  Statement not later
than the effective date of such Shelf Registration Statement;

                  (f) Notify each seller of such  Registrable  Securities at any
time when a prospectus  relating  thereto is required to be delivered  under the
Securities  Act,  of the  happening  of any  event  as a  result  of  which  the
prospectus  included  in such Shelf  Registration  Statement  contains an untrue

                                       17
<PAGE>
statement of a material fact or omits any fact  necessary to make the statements
therein not misleading, and, at the request of any such seller, the Company will
prepare a supplement  or amendment to such  prospectus  so that,  as  thereafter
delivered to the purchasers of such Registrable Securities, such prospectus will
not  contain an untrue  statement  of a material  fact or omit to state any fact
necessary to make the statements therein not misleading. The Purchasers agree to
suspend, upon request of the Company, any disposition of Registrable  Securities
pursuant to the Registration  Statement  contemplated  hereby during any period,
not to exceed one 30-day period per circumstance or development.

                  (g) Cause all such Registrable Securities to be listed on each
securities  exchange  or  automated  over-the-counter  trading  system  on which
similar securities issued by the Company are then listed;

                  (h) Enter into such customary  agreements  (including,  in the
event  Purchasers  elect to engage an underwriter  in connection  with the Shelf
Registration Statement, an underwriting agreement containing customary terms and
conditions)  and take all such other actions as reasonably  required in order to
expedite or facilitate the disposition of such Registrable Securities; and

                  (i) Make available for inspection by any seller of Registrable
Securities, all financial and other records, pertinent corporation documents and
properties  of the Company,  and cause the  Company's  officers,  directors  and
employees to supply all information  reasonably  requested by any such seller in
connection with the Shelf Registration Statement pursuant to Section 8.1.

                  8.3  Registration  and  Selling  Expenses.  (a)  All  expenses
incurred by the  Company in  connection  with the  Company's  performance  of or
compliance  with  this  Section  8,  including,   without   limitation  (i)  all
registration and filing fees (including all expenses incident to filing with the
National  Association  of  Securities  Dealers,  Inc.),  (ii)  blue sky fees and
expenses,  (iii) all necessary printing and duplicating expenses,  (iv) all fees
and disbursements of counsel and accountants  retained by the Company (including
the  expenses of any audit of  financial  statements)  and (v) a single  counsel
retained by the  Purchasers;  provided that the Company shall not be required to
pay for the costs of any in-house counsel and the amount of any fees for outside
counsel  shall be offset  against the $10,000 cap described in Section 11.2 (all
such expenses being called "Registration Expenses"), will be paid by the Company
except as otherwise expressly provided in this Section 8.3.

                  (b) The Company  will, in any event,  in  connection  with any
registration   statement,   pay  its  internal  expenses   (including,   without
limitation,  all salaries and expenses of its officers and employees  performing
legal, accounting or other duties in connection therewith and expenses of audits
of year-end financial  statements),  the expense of liability  insurance and the
expenses and fees for listing the  securities  to be  registered  on one or more
securities  exchanges or  automated  over-the-counter  trading  systems on which
similar securities issued by the Company are then listed.

                                       18
<PAGE>

                  (c) Nothing in this  Agreement  shall be  construed to prevent
any Holder or Holders of Registrable  Securities  from retaining such counsel as
they shall choose at their own expense.

                  8.4. Other Public Sales and Registrations.  The Company agrees
that it will not, on its own behalf, file or cause to become effective any other
registration  of any of its  securities  under the  Securities  Act or otherwise
effect a public  sale or  distribution  of its  securities  (except  pursuant to
registration  on Form S-8 and  Form  S-4 or any  successor  form  relating  to a
special  offering to the employees or security  holders of the Company) until at
least 60 days have elapsed  after the effective  date of the Shelf  Registration
Statement without the prior written consent of the Purchasers.

                  8.5. Indemnification.  (a) The Company shall indemnify, to the
extent permitted by law, each holder of Registrable Securities, its officers and
directors,  if any, and each person, if any, who controls such holder within the
meaning of the Securities Act, against all losses, claims, damages,  liabilities
and expenses (under the Securities Act or common law or otherwise) caused by any
untrue statement or alleged untrue statement of a material fact contained in any
registration  statement or  prospectus  (and as amended or  supplemented  if the
Company has furnished any amendments or supplements  thereto) or any preliminary
prospectus,  which registration statement,  prospectus or preliminary prospectus
shall be prepared  in  connection  with the  registration  contemplated  by this
Section 8, or caused by any  omission  or alleged  omission  to state  therein a
material fact required to be stated  therein or necessary to make the statements
therein  not  misleading,  except  insofar  as  such  losses,  claims,  damages,
liabilities  or expenses are caused by any untrue  statement  or alleged  untrue
statement  contained in or by any omission or alleged  omission from information
furnished  in  writing by such  holder to the  Company  in  connection  with the
registration  contemplated  by this Section 8,  provided the Company will not be
liable pursuant to this Section 8.5 if such losses, claims, damages, liabilities
or expenses have been caused by any selling security holder's failure to deliver
a copy  of the  registration  statement  or  prospectus,  or any  amendments  or
supplements thereto, after the Company has furnished such holder with the number
of copies required by Section 8.2(c).

                  (b) In connection with any  registration  statement in which a
holder of  Registrable  Securities  is  participating,  each such  holder  shall
furnish to the Company in writing such information as is reasonably requested by
the Company for use in any such  registration  statement or prospectus and shall
severally,  but not  jointly,  indemnify,  to the extent  permitted  by law, the
Company,  its directors  and officers and each person,  if any, who controls the
Company within the meaning of the Securities  Act,  against any losses,  claims,
damages, liabilities and expenses resulting from any untrue statement or alleged
untrue  statement of a material  fact or any  omission or alleged  omission of a
material fact required to be stated in the registration  statement or prospectus
or any  amendment  thereof  or  supplement  thereto  or  necessary  to make  the
statements therein not misleading,  but only to the extent such losses,  claims,
damages,  liabilities  or expenses are caused by an untrue  statement or alleged

                                       19
<PAGE>
untrue  statement  contained  in or by an  omission  or  alleged  omission  from
information  so  furnished  in writing  by such  holder in  connection  with the
registration  contemplated  by this Section 8. If the  offering  pursuant to any
such registration is made through underwriters, each such holder agrees to enter
into an underwriting  agreement in customary form with such  underwriters and to
indemnify such  underwriters,  their  officers and  directors,  if any, and each
person who controls such  underwriters  within the meaning of the Securities Act
to the same extent as hereinabove  provided with respect to  indemnification  by
such holder of the Company. Notwithstanding the foregoing or any other provision
of this  Agreement,  in no event  shall a holder of  Registrable  Securities  be
liable for any such losses, claims,  damages,  liabilities or expenses in excess
of the lesser of (a) the net proceeds received by such holder in the offering or
(b) $500,000.

                  (c)  Promptly  after  receipt by an  indemnified  party  under
Section  8.5  (a)  or (b)  of  notice  of the  commencement  of  any  action  or
proceeding,  such indemnified  party will, if a claim in respect thereof is made
against the indemnifying party under such Section, notify the indemnifying party
in  writing  of the  commencement  thereof;  but the  omission  so to notify the
indemnifying  party will not relieve it from any liability  which it may have to
any indemnified party otherwise than under such Section. In case any such action
or  proceeding is brought  against any  indemnified  party,  and it notifies the
indemnifying party of the commencement  thereof,  the indemnifying party will be
entitled to participate therein, and, to the extent that it wishes, jointly with
any other indemnifying party similarly notified,  to assume the defense thereof,
with  counsel  approved  by such  indemnified  party  (such  approval  not to be
unreasonably  withheld),  and after notice from the  indemnifying  party to such
indemnified  party  of its  election  so to  assume  the  defense  thereof,  the
indemnifying  party  will not be liable to such  indemnified  party  under  such
Section  for any  legal or any  other  expenses  subsequently  incurred  by such
indemnified  party in connection with the defense thereof (other than reasonable
costs  of  investigation)   unless  incurred  at  the  written  request  of  the
indemnifying  party.  Notwithstanding the above, the indemnified party will have
the right to employ  counsel of its own choice in any such action or  proceeding
if the  indemnified  party has  reasonably  concluded that there may be defenses
available  to it  which  are  different  from  or  additional  to  those  of the
indemnifying  party, or counsel to the indemnified  party is of the opinion that
it  would  not  be  desirable  for  the  same  counsel  to  represent  both  the
indemnifying party and the indemnified party because such  representation  might
result in a conflict  of  interest  (in either of which  cases the  indemnifying
party  will not have the  right to  assume  the  defense  of any such  action or
proceeding  on behalf of the  indemnified  party or  parties  and such legal and
other expenses will be borne by the indemnifying  party). An indemnifying  party
will not be  liable to any  indemnified  party  for any  settlement  of any such
action or proceeding effected without the consent of such indemnifying party.

                  (d) If the  indemnification  provided for in Section 8.5(a) or
(b) is unavailable  under  applicable law to an indemnified  party in respect of
any losses,  claims,  damages or  liabilities  referred  to  therein,  then each
applicable  indemnifying  party, in lieu of indemnifying such indemnified party,
shall  contribute to the amount paid or payable by such  indemnified  party as a
result of such losses,  claims,  damages or liabilities in such proportion as is
appropriate  to reflect the relative fault of the Company on the one hand and of
the Holders on the other in connection  with the  statements or omissions  which
resulted in such losses, claims,  damages, or liabilities,  as well as any other
relevant equitable considerations.  The relative fault of the Company on the one
hand and of the Holders on the other shall be  determined by reference to, among
other things,  whether the untrue or alleged untrue statement of a material fact
or the omission to state a material fact relates to information  supplied by the
Company or by the Holders and the parties' relative intent, knowledge, access to
information  and  opportunity  to correct or prevent such statement or omission.
The amount paid or payable by a party as a result of the losses, claims, damages
and  liabilities  referred to above  shall be deemed to include,  subject to the

                                       20
<PAGE>

limitations  set forth in Section  8.5(c),  any legal or other fees or  expenses
reasonably  incurred by such party in connection with investigating or defending
any action or claim.  No person guilty of fraudulent  misrepresentation  (within
the  meaning  of  Section  11(f) of the  Securities  Act)  will be  entitled  to
contribution   from  any   person   who  is  not   guilty  of  such   fraudulent
misrepresentation.

                  (e)  Promptly  after  receipt by the  Company or any holder of
Securities of notice of the commencement of any action or proceeding, such party
will,  if a claim for  contribution  in respect  thereof  is to be made  against
another party (the "contributing  party"),  notify the contributing party of the
commencement  thereof; but the omission so to notify the contributing party will
not  relieve it from any  liability  which it may have to any other  party other
than for contribution  under this Agreement.  In case any such action,  suit, or
proceeding is brought against any party,  and such party notifies a contributing
party of the commencement  thereof,  the contributing  party will be entitled to
participate  therein with the notifying party and any other  contributing  party
similarly notified.

                  8.6.   Additional   Common  Stock   Issuable   Upon  Delay  of
Registration and Other Events.  (a) Except to the extent any delay is due to the
failure of a Holder to  reasonably  cooperate  in  providing to the Company such
information  as shall be reasonably  requested by the Company in writing for use
in the Shelf Registration  Statement, if the Shelf Registration Statement is not
filed with the SEC  within 30 days  following  the  Closing  Date (the  "Outside
Target  Date"),  the Company  shall  immediately  declare,  issue and pay for no
additional  consideration to each Holder  additional  Common Shares equal to one
percent  (1%) of the Common  Shares  then held by such  Holder,  for each 15-day
period (or fraction thereof) after the Outside Target Date that the Registration
Statement remains unfiled.

                  (b) All  shares  of Common  Stock  issuable  pursuant  to this
Section 8.6 shall be duly  authorized,  fully paid and  nonassessable  shares of
Common  Stock  and  shall  be  included  in  the  Shelf  Registration  Statement
contemplated  by Section 8.1.  Such shares shall be  registered  in  Purchasers'
names or the name of the  nominee(s)  of  Purchasers  in such  denominations  as
Purchasers shall request pursuant to instructions delivered to the Company.

                  9. Certain  Definitions.  For the purposes of this  Agreement,
the following terms have the respective meanings set forth below:

                  9.1. "Affiliate" means any person, corporation, firm or entity
that  directly or  indirectly  controls,  is  controlled  by, or is under common
control with the indicated person, corporation, firm or entity.

                  9.2.     "Common Stock" means the Company's Common Stock.

                  9.3.    "Generally   Accepted  Accounting   Principles"  means
generally accepted accounting principles consistently applied.

                                       21
<PAGE>

                  9.4.   "Person"   shall  mean  any  natural   person  and  any
corporation,  partnership,  joint venture,  limited  liability  company or other
legal person, but shall not include any governmental entity.

                  9.5.     "Securities" means the Common Shares.

                  9.6.     "Securities  Act"  means,  as of any given time,  the
Securities Act of 1933, as amended, or any similar federal law then in force.

                  9.7.   "Exchange  Act"  means,  as  of  any  given  time,  the
Securities  Exchange Act of 1934, as amended, or any similar federal law then in
force.

                  9.8.  "SEC"  shall  mean  the  United  States  Securities  and
Exchange  Commission and includes any governmental  body or agency succeeding to
the functions thereof.

                  9.9.  "Subsidiary"  means  any  person,  corporation,  firm or
entity at least the majority of the equity  securities (or equivalent  interest)
of which are, at the time as of which any  determination is being made, owned of
record or  beneficially  by the  Company,  directly or  indirectly,  through any
Subsidiary or otherwise.

                  10.1  Indemnification.  (a) The Company  agrees to  indemnify,
defend and hold Purchasers and their officers,  directors,  partners,  employees
and consultants (the  "Purchasers'  Indemnitees")  harmless from and against any
direct damages or third-party  claims incurred or suffered by any of Purchasers'
Indemnitees as a result of or arising out of or in connection with the Company's
breach of any  representation,  warranty,  covenant or  agreement of the Company
contained in this Agreement. The Purchasers Indemnities will promptly notify the
Company  of any  potential  indemnification  claim upon  discovery  of the facts
supporting  the  potential  claim  and,  if such  indemnification  is based on a
third-party claim, allow the Company to defend, manage and resolve the matter at
the Company's cost and with the indemnities' reasonable cooperation.

                           (b) The  Purchasers  agree to  indemnify,  defend and
hold the  Company  and its  officers,  directors,  shareholders,  employees  and
consultants  (the  "Company  Indemnitees")  harmless from and against any direct
damages or third-party claims incurred or suffered by any of Company Indemnitees
as a result of or arising out of or in connection with the Purchasers' breach of
any representation,  warranty, covenant or agreement of the Purchasers contained
in this Agreement.  The Company  Indemnities will promptly notify the Purchasers
of any potential  indemnification  claim upon discovery of the facts  supporting
the  potential  claim and,  if such  indemnification  is based on a  third-party
claim,  allow the  Purchasers  to defend,  manage and  resolve the matter at the
Purchaser's cost and with the indemnities' reasonable cooperation.

                                       22
<PAGE>

                  11.      Miscellaneous.

                  11.1. Termination; Survival of Representations, Warranties and
Covenants.   Except  as   otherwise   provided   for  in  this   Agreement   all
representations,   warranties,   covenants  and  agreements  contained  in  this
Agreement,  or in any document,  exhibit,  schedule or  certificate by any party
delivered in  connection  herewith  shall  survive the execution and delivery of
this Agreement and the Closing Dates and the  consummation  of the  transactions
contemplated  hereby,  regardless of any investigation  made by Purchasers or on
their behalf.

                  11.2. Expenses.  The Company shall pay all its own expenses in
connection with this Agreement and the  transactions  contemplated  herein.  The
Company  agrees to pay  promptly  all  out-of-pocket  expenses  incurred  by the
Purchasers in connection with the preparation and  consummation of the Agreement
and the  transactions  contemplated  herein,  including but not limited to legal
fees  and  disbursements  of the  Purchasers'  counsel  in  connection  with the
preparation and consummation of this Agreement and the transactions contemplated
herein,   including   the  legal  fees  (other  than  legal  fees  for  in-house
counsel)_and  costs of negotiating and drafting any transaction  documents,  due
diligence and any necessary regulatory filings,  provided the total expenses for
which the Company is responsible shall be limited to $10,000.

                  11.3.  Amendments and Waivers. This Agreement and the exhibits
and schedules hereto set forth the entire agreement and understanding  among the
parties as to the  subject  matter  hereof and merges and  supersedes  all prior
discussions,  agreements and  understandings of any and every nature among them.
This  Agreement may be amended only by mutual  written  agreement of the Company
and the  Purchasers,  and the Company may take any action  herein  prohibited or
omit to take any action herein required to be performed by it, and any breach of
any covenant,  agreement,  warranty or representation may be waived, only if the
Company has obtained the written  consent or waiver of a majority in interest of
the  Purchasers.  No course of dealing  between or among any persons  having any
interest  in this  Agreement  will be  deemed  effective  to  modify,  amend  or
discharge any part of this  Agreement or any rights or obligations of any person
under or by reason of this Agreement.

                  11.4.  Successors  and  Assigns.  This  Agreement  may  not be
assigned by the Company except with the prior written consent of the Purchasers.
This Agreement shall be binding upon and inure to the benefit of the Company and
its permitted  successors and assigns and  Purchasers  and their  successors and
assigns.  The provisions hereof which are for Purchasers'  benefit as purchasers
or holders of the Common Shares are also for the benefit of, and enforceable by,
any subsequent holder of such Common Shares.

                  11.5. Notices.  All notices,  demands and other communications
to be given or delivered  under or by reason of the provisions of this Agreement
shall be in writing  and shall be deemed to have been given  personally  or when
mailed by certified or registered  mail,  return  receipt  requested and postage
prepaid,  and  addressed to the  addresses of the  respective  parties set forth
below or to such  changed  addresses  as such  parties may have fixed by notice;
provided,  however, that any notice of change of address shall be effective only
upon receipt:

                                       23
<PAGE>

                           If to the Company:
                           Immunomedics, Inc.
                           300 American Road
                           Morris Plains, New Jersey 07950
                           Attn: Dr. David M. Goldenberg

                           With a Copy (which shall not constitute notice) to:

                           Lowenstein Sandler PC
                           65 Livingston Avenue
                           Roseland, New Jersey 07065
                           Attn:  Peter H. Ehrenberg

                           If to the Purchasers:

                           The Aries Master Fund
                           The Aries Domestic Fund, L.P.
                           The Aries Domestic Fund II, L.P.
                           c/o Paramount Capital Asset Management, Inc.
                           787 Seventh Avenue, 48th Floor
                           New York, NY 10019
                           Attn: David M.  Tanen

                  11.6.  Governing Law; Consent to  Jurisdiction.  The validity,
performance,  construction  and effect of this  Agreement  shall be  governed by
those laws of the State of Delaware.  The parties hereto irrevocably  consent to
the jurisdiction of the courts of the State of New York and of any federal court
located in such State in connection with any action or proceeding arising out of
or relating to this Agreement, any document or instrument delivered pursuant to,
in connection with or  simultaneously  with this Agreement,  or a breach of this
Agreement or any such document or instrument.

                  11.7.  Counterparts.  This  Agreement  may be  executed in any
number of  counterparts  and,  notwithstanding  that any of the  parties did not
execute the same counterpart, each of such counterparts shall, for all purposes,
be deemed an original,  and all such  counterparts  shall constitute one and the
same instrument binding on all of the parties thereto.

                  11.8. Headings. The headings of the Sections are inserted as a
matter of  convenience  and for  reference  only and in no way define,  limit or
describe the scope of this Agreement or the meaning of any provision hereof.

                  11.9.  Severability.  In the event that any  provision of this
Agreement or the application of any provision  hereof is declared to be illegal,
invalid or otherwise  unenforceable  by a court of competent  jurisdiction,  the
remainder of this Agreement shall not be affected except to the extent necessary
to delete such illegal,  invalid or unenforceable provision unless the provision
held invalid shall substantially  impair the benefit of the remaining portion of
this Agreement.

                                       24
<PAGE>

                  11.10.  Freedom of Action. The Purchasers and their Affiliates
shall have no obligation to the Company to refrain from (i) engaging in the same
or similar  activities  or lines of business as the Company or develop or market
any products,  services or technologies  that does or may in the future compete,
directly or indirectly,  with those of the Company, (ii) investing or owning any
interest publicly or privately in, or develop a business  relationship with, any
corporation,  partnership  or other  person  or  entity  engaged  in the same or
similar  activities or lines or business as, or otherwise in  competition  with,
the Company or (iii) doing  business  with any client,  collaborator,  licensor,
consultant,  vendor or customer of the Company. It is agreed and understood that
the  preceding  sentence  shall not limit the  obligations  to the Company under
applicable  law of any person acting as a director of the Company,  nor shall it
limit the obligations of the Purchasers or their Affiliates under this Agreement
or any other agreement with the Company.

                  11.11.   Exculpation   Among   Purchasers.    Each   Purchaser
acknowledges and agrees that it is not relying upon any other Purchaser,  or any
officer, director, employee partner or affiliate of any such other Purchaser, in
making its investment or decision to invest in the Company or in monitoring such
investment.  Each Purchaser agrees that no Purchaser nor any controlling person,
officer,  director,  stockholder,  partner,  agent or employee of any  Purchaser
shall be liable for any action  heretofore  or hereafter  taken or omitted to be
taken  by any of them  relating  to or in  connection  with the  Company  or the
securities, or both.

                  11.12.  Actions by  Purchasers.  Any actions  permitted  to be
taken by holders or Purchasers of Common Shares and any consents  required to be
obtained from the same under this  Agreement,  may be taken or given only by, in
the case of  consents  or actions  requiring  approval  of a  Purchaser,  by the
applicable Purchaser,  and in all other cases, except to the extent inconsistent
with any explicit provision of this Agreement,  only by holders of a majority in
interest of the Common Shares.

                                       25
<PAGE>



         IN WITNESS WHEREOF,  the parties have executed this Agreement as of the
day and year first above written.

IMMUNOMEDICS, INC.                        THE ARIES MASTER FUND


By: /s/ David M. Goldenberg               By: /s/ Lindsay Rosenwald, M.D.
Name:  David M. Goldenberg                Name:  Lindsay Rosenwald, M.D.
Title: Chairman and Chief                 Title: Chairman of Paramount Capital
       Executive Officer                         Asset Management, Inc.
                                                 Investment Manager

ARIES DOMESTIC FUND, L.P.                 ARIES DOMESTIC FUND II, L.P.



By: /s/ Lindsay Rosenwald, M.D.           By: /s/ Lindsay Rosenwald, M.D.
Name:  Lindsay Rosenwald, M.D.            Name:  Lindsay Rosenwald, M.D.
Title: Chairman of Paramount Capital      Title: Chairman of Paramount Capital
       Asset Management, Inc.                    Asset Management, Inc.
       General Partner                           General Partner


LINDSAY A. ROSENWALD, M.D.                MARK C. ROGERS, M.D.



By: /s/ Lindsay Rosenwald, M.D.           By: /s/ Marc C. Rogers, M.D.
Name:  Lindsay Rosenwald, M.D.            Name:  Mark C. Rogers, M.D.


WAYNE ROTHBAUM


By: /s/ Wayne Rothbaum
Name:  Wayne Rothbaum

                                       26
<PAGE>



                                    EXHIBIT A



Name                                                     Initial
                                     $ Amount         Common Shares
- --------------------------------  --------------    ----------------

The Aries Master Fund, a
Cayman Island exempted
Company:                            $4,672,935         1,557,645

The Aries Domestic Fund, L.P.       $1,880,460           626,820

The Aries Domestic Fund II, L.P.    $  146,601            48,867

Lindsay A. Rosenwald, M.D.          $  500,001           166,667

Mark C. Rogers, M.D.                $  100,002            33,334
Wayne Rothbaum                      $  200,001            66,667

                                       27
<PAGE>



December 16, 1999

                                WARRANT AGREEMENT

THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE  THEREOF HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR
ANY STATE  SECURITIES  LAWS,  AND MAY NOT BE SOLD,  OFFERED  FOR SALE,  PLEDGED,
HYPOTHECATED  OR  OTHERWISE   TRANSFERRED  UNLESS  THERE  IS  (i)  AN  EFFECTIVE
REGISTRATION  STATEMENT  UNDER  SUCH ACT  RELATED  THERETO,  (ii) AN  OPINION OF
COUNSEL  FOR THE  HOLDER,  REASONABLY  SATISFACTORY  TO THE  COMPANY,  THAT SUCH
REGISTRATION  IS NOT REQUIRED,  (iii) RECEIPT OF A NO-ACTION  LETTER(S) FROM THE
APPROPRIATE GOVERNMENTAL AUTHORITY(IES).

                               IMMUNOMEDICS, INC.

                WARRANT TO PURCHASE 75,000 SHARES OF COMMON STOCK

         IMMUNOMEDICS,  INC., a Delaware  corporation  (the  "Company"),  hereby
certifies  that,  for value  received,  Sutro & Co.  Incorporated  ("Sutro"),  a
_________  corporation,  or its  registered  transferees,  successors or assigns
(each,  a "holder"),  is the registered  holder of warrants (the  "Warrants") to
subscribe for and purchase  SEVENTY-FIVE  THOUSAND  (75,000) shares of the fully
paid and  nonassessable  Common Stock (as adjusted pursuant to Section 4 hereof,
the "Warrant Shares") of the Company, at a purchase price per share equal to SIX
DOLLARS AND FIFTY CENTS ($6.50) (such price,  as adjusted  pursuant to Section 4
hereof,  the "Warrant Price"),  subject to the provisions and upon the terms and
conditions  hereinafter set forth.  As used herein,  (a) the term "Common Stock"
shall mean the Company's  presently  authorized Common Stock, par value $.01 per
share,  and any stock  into or for which  such  Common  Stock may  hereafter  be
converted or exchanged, and (b) the term "Date of Grant" shall mean December 16,
1999.  The term  "Warrant" as used herein shall be deemed to include any warrant
issued upon  transfer or partial  exercise of this  Warrant,  unless the context
clearly  requires  otherwise.  This  Warrant is being  issued  pursuant  to that
certain  Letter  Engagement  Agreement (the  "Agreement")  of even date herewith
between the Company and Sutro.

         1.       Term.

         The purchase right represented by this Warrant is exercisable, in whole
or in part, at any time and from time to time from the Date of Grant through and
including  the close of business on December 16, 2004 (the  "Expiration  Date");
provided,  however,  that in the  event  that any  portion  of this  Warrant  is
unexercised  as of the  Expiration  Date,  the terms of Section 2(b) below shall
apply.

<PAGE>

         2.       Exercise.

                  a.       Method of Exercise; Payment; Issuance of New Warrant.

                  Subject to Section 1 hereof, the purchase right represented by
this Warrant may be exercised by the holder hereof, in whole or in part and from
time to time, by the surrender of this Warrant (with the notice of exercise form
attached  hereto as  Exhibit A duly  executed)  at the  principal  office of the
Company,  and,  except as otherwise  provided for herein,  by the payment to the
Company of an amount equal to the then  applicable  Warrant Price  multiplied by
the number of Warrant  Shares  then  being  purchased.  The person or persons in
whose name(s) any  certificate(s)  representing  shares of Common Stock shall be
issuable  upon  exercise  of this  Warrant  shall be deemed to have  become  the
holder(s)  of record  of, and shall be treated  for all  purposes  as the record
holder(s) of, the shares represented thereby (and such shares shall be deemed to
have been  issued)  immediately  prior to the close of  business  on the date or
dates upon which this Warrant is  exercised  if exercised  prior to the close of
business on such date; otherwise,  the date of record shall be the next business
day. In the event of any  exercise of the rights  represented  by this  Warrant,
certificates  for the shares of Common Stock so purchased  shall be delivered to
the holder  hereof as soon as  possible  after such  exercise  and,  unless this
Warrant  has  been  fully  exercised  (including  without  limitation,  exercise
pursuant to Section 2(b) below),  a new Warrant  representing the portion of the
Warrant  Shares,  if any, with respect to which this Warrant shall not then have
been exercised shall also be issued to the holder hereof as soon as possible.

                  b. Automatic  Exercise.  In the event that any portion of this
Warrant remains  unexercised as of the Expiration Date and the fair market value
(determined in accordance  with Section 4(i) below) of one share of Common Stock
as of the Expiration Date is greater than the applicable Warrant Price as of the
Expiration  Date,  then this  Warrant  shall be  deemed  to have been  exercised
automatically  immediately prior to the close of business on the Expiration Date
(or,  in the  event  that  the  Expiration  Date  is  not a  business  day,  the
immediately   preceding  business  day)  (the  "Automatic   Exercise  Date")  in
accordance  with  Section  2(c)  below,  and the person  entitled to receive the
shares of Common  Stock  issuable  upon such  exercise  shall be treated for all
purposes  as the  holder  of record  of such  Warrant  Shares as of the close of
business on such  Automatic  Exercise  Date.  This Warrant shall be deemed to be
surrendered  to the  Company on the  Automatic  Exercise  Date by virtue of this
Section  2(b) and without any action by the holder of this  Warrant or any other
person,  upon the payment to the Company of the then  applicable  Warrant  Price
multiplied by the number of Warrant Shares then being  purchased shall be deemed
to be made pursuant to the terms of Section 2(c) below  (without  payment by the
holder of any exercise price or any cash or other consideration). As promptly as
practicable on or after the Automatic Exercise Date but in no event prior to the
date on which this Warrant is surrendered to the Company at the principal office
of the Company, the Company at its expense shall issue and deliver to the person
or persons  entitled to receive the same a certificate or  certificates  for the
number of Warrant Shares issuable upon such exercise, in accordance with Section
2(c).

                                      -2-
<PAGE>

                  c. Cashless  Right to Convert  Warrant into Common Stock;  Net
Issuance.

                           (1)      Right to Convert.

                  In addition to and without  limiting  the rights of the holder
hereof  under the terms of this  Warrant,  the  holder  shall  have the right to
convert this Warrant or any portion thereof (the "Conversion Right") into shares
of Common  Stock as  provided in this  Section  2(c) at any time or from time to
time during the term of this Warrant. Upon exercise of the Conversion Right with
respect to all or a specified  portion of shares  subject to this  Warrant  (the
"Converted  Warrant  Shares"),  the Company shall deliver to the holder (without
payment by the holder of any exercise price or any cash or other  consideration)
that number of shares of fully paid and nonassessable  Common Stock equal to the
quotient  obtained by dividing (i) the value of this  Warrant (or the  specified
portion hereof) on the Conversion  Date (as defined in Section 2(c)(2)  hereof),
which  value  shall be  equal  to (A) the  aggregate  fair  market  value of the
Converted  Warrant  Shares  issuable  upon  exercise  of  this  Warrant  (or the
specified  portion hereof) on the Conversion Date less (B) the aggregate Warrant
Price of the Converted  Warrant Shares  immediately prior to the exercise of the
Conversion  Right by (ii) the fair market value of one (1) share of Common Stock
on the  Conversion  Date.  Expressed  as a  formula,  such  conversion  shall be
computed as follows:

X  =  A - B
      -----
        Y
Where:            X = the number of shares of Common Stock that may be issued to
the holder

Y = the fair  market  value  ("FMV")  of one (1) share of  Common  Stock
A = the aggregate FMV (i.e., FMV x Converted  Warrant Shares)
B = the aggregate Warrant Price (i.e., Converted Warrant Shares x Warrant Price)

No fractional  shares shall be issuable upon exercise of the  Conversion  Right,
and,  if the number of shares to be issued  determined  in  accordance  with the
foregoing  formula is other than a whole  number,  the Company  shall pay to the
holder  an  amount  in cash  equal to the  fair  market  value of the  resulting
fractional  share on the  Conversion  Date.  For  purposes  of Section 9 of this
Warrant,  shares issued pursuant to the Conversion  Right shall be treated as if
they were issued upon the exercise of this Warrant.

                           (2)      Method of Exercise.

     The  Conversion  Right may be exercised  by the holder by the  surrender of
this  Warrant at the  principal  office of the Company  together  with a written
statement  specifying that the holder thereby intends to exercise the Conversion
Right and  indicating  the number of shares  subject to this  Warrant  which are
being  surrendered  (referred  to in  Section  2(c)(1)  hereof as the  Converted
Warrant Shares) in exercise of the Conversion  Right.  Such conversion  shall be
effective  upon  receipt  by the  Company  of this  Warrant  together  with  the
aforesaid written statement,  or on such later date as is specified therein (the
"Conversion  Date").  Certificates  for the shares issuable upon exercise of the
Conversion Right and, if applicable, a new warrant evidencing the balance of the
shares remaining  subject to this Warrant,  shall be issued as of the Conversion

                                      -3-
<PAGE>

Date and shall be  delivered  to the holder as soon as  possible  following  the
Conversion Date.

                           (3)      Determination of Fair Market Value.

                  d.       For purposes of Section 2(c), "fair market  value" of
a share of Common Stock shall have the meaning set forth in Section 4(i) below.

         3.       Stock Fully Paid; Reservation of Shares.

         All Warrant  Shares that may be issued upon the  exercise of the rights
represented  by this  Warrant  will,  upon  issuance  pursuant  to the terms and
conditions  herein,  be fully paid and  nonassessable,  and free from all taxes,
liens,  charges,  and  statutory  pre-emptive  rights with  respect to the issue
thereof.  The Company shall pay all transfer taxes, if any,  attributable to the
issuance of the Warrant Shares upon the exercise of this Warrant,  provided that
such Warrant Shares are issued in the name of the holder of this Warrant. During
the period within which the rights represented by this Warrant may be exercised,
the Company will at all times have  authorized,  and reserved for the purpose of
the issue upon  exercise of the purchase  rights  evidenced by this  Warrant,  a
sufficient  number of shares of its Common  Stock to provide for the exercise of
the rights represented by this Warrant.

         4.       Adjustment of Warrant Price and Number of Shares.

         The number and kind of securities purchasable upon the exercise of this
Warrant and the Warrant Price shall be subject to  adjustment  from time to time
upon the occurrence of certain events, as follows:

                  a.       Intentionally omitted.

                  b.       Merger, Sale, Reclassification.

                  In case of any (i) consolidation or merger (including a merger
in which the Company is the surviving entity), (ii) sale or other disposition of
all or substantially  all of the Company's assets or distribution of property to
stockholders  (other  than  distributions  payable  out of  earnings or retained
earnings), or (iii) reclassification,  change or conversion of securities of the
class  issuable upon exercise of this Warrant (other than a change in par value,
or from par value to no par value,  or from no par value to par  value,  or as a
result  of a  subdivision  or  combination),  then the  Company  shall  take all
necessary actions  (including but not limited to executing and delivering to the
holder of this Warrant an additional  Warrant or other  instrument,  in form and
substance  acceptable  to the holder of this Warrant such  acceptance  not to be
unreasonably  withheld)  to  ensure  that  the  holder  of  this  Warrant  shall
thereafter  have the right to receive,  at a total  purchase price not to exceed
that payable upon the exercise of the unexercised  portion of this Warrant,  and
in lieu of the shares of Common Stock theretofore issuable upon exercise of this
Warrant,  the kind and amount of shares of stock,  other  securities,  money and
property receivable upon such consolidation,  merger, sale or other disposition,

                                      -4-
<PAGE>

reclassification,  change or  conversion  by a holder of the number of shares of
Common Stock then purchasable under this Warrant. Such new Warrant shall provide
for adjustments that shall be as nearly  equivalent as may be practicable to the
adjustments  provided for in this Section 4. The provisions of this Section 4(b)
shall similarly apply to successive reclassifications, changes and conversions.

                  c.       Subdivision or Combination of Shares.

                  If  the  Company  at  any  time  while  this  Warrant  remains
outstanding and unexpired  shall subdivide or combine its outstanding  shares of
Common Stock, the Warrant Price shall be  proportionately  decreased in the case
of a  subdivision  or increased in the case of a  combination,  effective at the
close of business on the date the subdivision or combination becomes effective.

                  d.       Stock Dividends and Other Distributions.

                  If the Company at any time while this  Warrant is  outstanding
and  unexpired  shall (i) pay a dividend with respect to Common Stock payable in
Common Stock, or (ii) make any other  distribution  with respect to Common Stock
(except any  distribution  specifically  provided for in Section 4(b) or Section
4(c) hereof) of Common Stock, then the Warrant Price shall be adjusted, from and
after  the date of  determination  of  stockholders  entitled  to  receive  such
dividend or  distribution,  to that price  determined by multiplying the Warrant
Price in effect  immediately  prior to such date of  determination by a fraction
(i) the  numerator  of which shall be the total number of Fully  Diluted  Shares
outstanding  immediately  prior to such dividend or  distribution,  and (ii) the
denominator  of  which  shall  be the  total  number  of  Fully  Diluted  Shares
outstanding immediately after such dividend or distribution.

                  e.       Rights Offerings.

                  In case  the  Company  shall,  at any time  after  the Date of
Grant,  issue  rights,  options or warrants  generally  to the holders of equity
securities of the Company, entitling them to subscribe for or purchase shares of
Common Stock (or securities  convertible or exchangeable into Common Stock) at a
price per share of Common  Stock (or having a conversion  or exchange  price per
share of Common  Stock if a security  convertible  or  exchangeable  into Common
Stock) less than the fair market  value per share of Common  Stock on the record
date for such  issuance (or the date of issuance,  if there is no record  date),
the Warrant  Price to be in effect on and after such  record  date (or  issuance
date,  as the case may be) shall be  adjusted  so that it shall  equal the price
determined by multiplying the Warrant Price in effect  immediately prior to such
record  date  (or  issuance  date,  as the case  may be) by a  fraction  (i) the
numerator of which shall be the number of shares of Common Stock  outstanding on
such  record  date (or  issuance  date,  as the case may be) plus the  number of
shares of Common Stock which the aggregate offering price of the total number of
shares of such Common Stock so to be offered (or the aggregate  initial exchange
or  conversion  price of the  exchangeable  or  convertible  securities so to be
offered)  would  purchase  at such fair  market  value on such  record  date (or
issuance  date, as the case may be) and (ii) the  denominator  of which shall be
the  number of  shares  of Common  Stock  outstanding  on such  record  date (or
issuance  date,  as the case may be) plus the  number  of  additional  shares of
Common  Stock to be offered  for  subscription  or  purchase  (or into which the
convertible securities to be offered are initially exchangeable or convertible).
In case such subscription  price may be paid in part or in whole in a form other

                                      -5-
<PAGE>

than cash,  the fair market value of such  consideration  shall be determined by
the  Board of  Directors  of the  Company  in good  faith as set forth in a duly
adopted  board  resolution  certified  by the  Company's  Secretary or Assistant
Secretary,  provided, that in the event the Board of Directors is unable to make
such a determination,  then the fair market value of such consideration shall be
determined  in the same manner as a Valuation  under  Section  4(i) below.  Such
adjustment shall be made successively  whenever such an issuance occurs;  and in
the event that such rights,  options,  warrants,  or convertible or exchangeable
securities  are  not  so  issued  or  expire  or  cease  to  be  convertible  or
exchangeable before they are exercised, converted, or exchanged (as the case may
be), then the Warrant Price shall again be adjusted to be the Warrant Price that
would then be in effect if such issuance had not occurred,  but such  subsequent
adjustment  shall not  affect  the  number of  Warrant  Shares  issued  upon any
exercise of this Warrant prior to the date such subsequent adjustment is made.

                  f.       Other Special Distributions.

                  In case the Company  shall fix a record date for the making of
a distribution (other than dividends,  distributions or issuances referred to in
Section 4(c), Section 4(d) or Section 4(e) above, and other than cash dividends)
to all holders of shares of Common Stock (including any such  distribution  made
in  connection  with a  consolidation  or  merger in which  the  Company  is the
surviving  corporation)  of evidences of  indebtedness,  assets or  subscription
rights, options,  warrants, or exchangeable or convertible securities containing
the right to subscribe for or purchase shares of any class of equity  securities
of the Company,  the Warrant Price to be in effect on and after such record date
shall be adjusted by multiplying the Warrant Price in effect  immediately  prior
to such record date by a fraction  (i) the  numerator of which shall be the fair
market  value per share of  Common  Stock on such  record  date  (determined  in
accordance  with Section 4(i) below),  less the fair market value (as determined
by the Board of  Directors  of the  Company in good faith as set forth in a duly
adopted  board  resolution  certified  by the  Company's  Secretary or Assistant
Secretary)  of the portion of the assets or evidences of  indebtedness  so to be
distributed or of such subscription rights,  options,  warrants, or exchangeable
or  convertible  securities  applicable  to one (1)  share of the  Common  Stock
outstanding  as of such record  date,  provided,  that in the event the Board of
Directors is unable to make such a determination,  then the fair market value of
such  consideration  shall be determined in the same manner as a Valuation under
Section 4(i) below,  and (ii) the  denominator of which shall be the fair market
value per share of Common  Stock as  determined  in the manner  set forth  under
Section 4(i) below. Such adjustment shall be made  successively  whenever such a
record date is fixed;  and in the event that such  distribution  is not so made,
the Warrant  Price  shall again be adjusted to be the Warrant  Price which would
then be in effect if such record date had not been  fixed,  but such  subsequent
adjustment  shall not  affect  the  number of  Warrant  Shares  issued  upon any
exercise of this Warrant prior to the date such subsequent adjustment was made.

                                       -6-
<PAGE>

                  g.        Other Issuances of Securities.

                  Shares  outstanding  immediately after such sale and issuance.
Such adjustment shall be made successively whenever such an issuance is made.

                  h.       Adjustment of Number of Shares.

                  Upon each  adjustment  in the  Warrant  Price,  the  number of
Warrant Shares  purchasable  hereunder  shall be adjusted,  to the nearest whole
share,  to the product  obtained  by  multiplying  the number of Warrant  Shares
purchasable  immediately  prior to such  adjustment  in the  Warrant  Price by a
fraction, the numerator of which shall be the Warrant Price immediately prior to
such  adjustment  and the  denominator  of  which  shall  be the  Warrant  Price
immediately thereafter.

                  i.       Determination of Fair Market Value.

                  For purposes of those  provisions of this Warrant  requiring a
determination  in accordance with this Section 4(i), "fair market value" as of a
particular  date (the  "Determination  Date") shall mean (i) for any security if
such security is traded on a national securities  exchange (an "Exchange"),  the
weighted  average (based on daily trading  volume) of the mid-point  between the
daily high and low trading  prices of the  security on each of the last five (5)
trading days prior to the Determination Date reported on such Exchange, (ii) for
any security that is not traded on an Exchange but which is quoted on the Nasdaq
Stock Market ("NASDAQ"), the weighted average (based on daily trading volume) of
the mid-point  between the daily high and low trading prices  reported on NASDAQ
on each of the last five (5) trading days (or if the relevant price or quotation
did not exist on any of such days,  the relevant  price or quotation on the next
preceding business day on which there was such a price or quotation, for a total
of five trading days) prior to the Determination Date, or (iii) for any security
or any  other  asset,  if no price can be  determined  on the basis of the above
methods of valuation, then the judgment of valuation shall be determined in good
faith by the Board of  Directors of the Company,  which  determination  shall be
described  in a  duly  adopted  board  resolution  certified  by  the  Company's
Secretary  or Assistant  Secretary.  If the Board of Directors of the Company is
unable to determine any Valuation (as defined  below),  the Company shall select
an investment  banking firm of national  reputation which has not had a material
relationship with the Company or any officer of the Company within the preceding
two (2) years,  which shall  determine such Valuation.  Such investment  banking
firm's determination of such Valuation shall be final, binding and conclusive on
the Company and the holders of all of the  Warrants  issued  hereunder  and then
outstanding,  to the  extent  of the  issuance  or  distribution  to which  such
Valuation  applies.  If the Board of  Directors  of the  Company  was  unable to
determine such  Valuation,  all costs and fees of such  investment  banking firm
shall be borne by the  Company.  For  purposes of this  Section  4(i),  the term
"Valuation" shall mean the  determination,  to be made initially by the Board of
Directors  of the  Company,  of the fair market  value of any asset  pursuant to
clause (iii) above in this paragraph.

                                      -7-
<PAGE>

         5.       Notice of Adjustments.

         Whenever the Warrant Price or the number of Warrant Shares  purchasable
hereunder shall be adjusted pursuant to Section 4 hereof, the Company shall make
a certificate signed by its chief financial officer setting forth, in reasonable
detail,  the event requiring the adjustment,  the amount of the adjustment,  the
method by which such  adjustment was  calculated,  and the Warrant Price and the
number of Warrant  Shares  purchasable  hereunder  after  giving  effect to such
adjustment, which shall be mailed (without regard to Section 11 hereof, by first
class mail, postage prepaid) to the holder of this Warrant.

         6.       Fractional Shares.

         No fractional  shares of Common Stock will be issued in connection with
any exercise hereunder,  but in lieu of such fractional shares the Company shall
make a cash payment  therefor  based on the fair market value (as  determined in
accordance  with  Section  4(i) above) of a share of Common Stock on the date of
exercise.

         7. Compliance  with  Securities Act;  Disposition of Warrant or Warrant
Shares.

                  a.       Compliance with Securities Act.

                  The holder of this Warrant, by acceptance hereof,  agrees that
this Warrant and the shares of Common Stock to be issued upon  exercise  hereof,
are being acquired for  investment and that such holder will not offer,  sell or
otherwise  dispose of this  Warrant,  or any shares of Common Stock to be issued
upon  exercise  hereof  except  under  circumstances  which will not result in a
violation of the Securities  Act of 1933, as amended (the "Act").  Upon exercise
of this Warrant,  the holder  hereof shall confirm in writing,  by executing the
form attached as Schedule 1 to Exhibit A hereto, that the shares of Common Stock
so  purchased  are being  acquired  for  investment  and not with a view  toward
distribution or resale.  All shares of Common Stock issued upon exercise of this
Warrant (unless  registered  under the Act) shall be stamped or imprinted with a
legend in  substantially  the following form: "THE SECURITIES  EVIDENCED  HEREBY
HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS AMENDED,  OR ANY
STATE  SECURITIES  LAWS. NO SALE OR DISPOSITION  MAY BE EFFECTED  WITHOUT (i) AN
EFFECTIVE REGISTRATION STATEMENT RELATED THERETO, (ii) AN OPINION OF COUNSEL FOR
THE HOLDER,  REASONABLY  SATISFACTORY TO THE COMPANY,  THAT SUCH REGISTRATION IS
NOT REQUIRED,  or (iii) RECEIPT OF A NO-ACTION  LETTER(S)  FROM THE  APPROPRIATE
GOVERNMENTAL AUTHORITY(IES)"

                  In addition,  in connection with the issuance of this Warrant,
the holder specifically  represents to the Company by acceptance of this Warrant
as follows:

     (1) The holder is aware of the  Company's  business  affairs and  financial
condition, and has acquired information about the Company sufficient to reach an
informed  and  knowledgeable  decision to acquire  this  Warrant.  The holder is
acquiring this Warrant for its own account for investment  purposes only and not
with a view to, or for resale in connection with any "distribution"  thereof for
purposes of the Act.

                                      -8-
<PAGE>

     (2) The holder  understands  that this Warrant and the Warrant  Shares have
not  been  registered  under  the  Act in  reliance  upon a  specific  exemption
therefrom,  which  exemption  depends upon,  among other  things,  the bona fide
nature  of  the  holder's   investment  intent  as  expressed  herein.  In  this
connection,  the holder  understands  that,  in the view of the  Securities  and
Exchange  Commission  (the "SEC"),  the statutory basis for such exemption maybe
unavailable if the holder's  representation was predicated solely upon a present
intention  to hold the Warrant and the  Warrant  Shares for the minimum  capital
gains period  specified  under  applicable tax laws, for a deferred sale, for or
until an increase or decrease in the market price of the Warrant and the Warrant
Shares, or for a period of one (1) year or any other fixed period in the future.

     (3) The holder further understands that this Warrant and the Warrant Shares
must be held indefinitely unless  subsequently  registered under the Act and any
applicable  state securities  laws, or unless  exemptions from  registration are
otherwise available.

     (4) The holder is aware of the provisions of Rule 144 and 144A, promulgated
under the Act, which, in substance,  permit limited public resale of "restricted
securities" acquired,  directly or indirectly,  from the issuer thereof (or from
an  affiliate  of  such  issuer),  in  a  non-public  offering  subject  to  the
satisfaction  of certain  conditions,  if  applicable,  including,  among  other
things:  the availability of certain public  information about the Company,  the
resale  occurring  not less than one (1) year after the party has  purchased and
paid for the  securities to be sold;  the sale being made through a broker in an
unsolicited  "broker's  transaction" or in  transactions  directly with a market
maker (as said term is defined  under the  Securities  Exchange Act of 1934,  as
amended) and the amount of securities  being sold during any three-month  period
not exceeding the specified limitations stated therein.

     (5) The holder further  understands that at the time it wishes to sell this
Warrant and the Warrant  Shares there may be no public market upon which to make
such a sale, and that, even if such a public market then exists, the Company may
not be satisfying the current public  information  requirements  of Rule 144 and
144A,  and that,  in such event,  the holder may be precluded  from selling this
Warrant and the Warrant  Shares under Rule 144 and 144A even if the one (1)-year
minimum holding period had been satisfied.

     (6)  The  holder  further   understands  that  in  the  event  all  of  the
requirements of Rule 144 and 144A are not satisfied, registration under the Act,
compliance  with  Regulation  A, or some other  registration  exemption  will be
required;  and  that,  notwithstanding  the fact  that  Rule 144 and 144A is not
exclusive, the Staff of the SEC has expressed its opinion that persons proposing
to sell private  placement  securities  other than in a registered  offering and
otherwise  than pursuant to Rule 144 and 144A will have a substantial  burden of
proof in establishing  that an exemption from registration is available for such
offers or  sales,  and that  such  persons  and  their  respective  brokers  who
participate in such transactions do so at their own risk.

                                      -9-
<PAGE>

                  b. Disposition of Warrant or Warrant Shares.  This Warrant and
the  Warrant  Shares  may be  detached  and  transferred,  in  whole or in part,
separately from the Agreement.

                  With respect to any offer,  sale or other  disposition of this
Warrant, or any Warrant Shares acquired pursuant to the exercise of this Warrant
prior to registration  of such Warrant or Warrant Shares,  the holder hereof and
each  subsequent  holder of this Warrant  agrees to give  written  notice to the
Company prior thereto,  describing  briefly the manner thereof,  together with a
written  opinion  of such  holder's  counsel,  if  reasonably  requested  by the
Company,  to the  effect  that  such  offer,  sale or other  disposition  may be
effected without  registration or qualification (under the Act as then in effect
or any  federal  or state law then in effect)  of this  Warrant or such  Warrant
Shares and indicating whether or not under the Act certificates for this Warrant
or  such  Warrant  Shares  to be sold  or  otherwise  disposed  of  require  any
restrictive legend as to applicable  restrictions on transferability in order to
ensure  compliance  with  applicable  law.  Promptly upon receiving such written
notice and reasonably  satisfactory  opinion,  if so requested,  the Company, as
promptly as  practicable,  shall notify such holder that such holder may sell or
otherwise dispose of this Warrant or such Warrant Shares, all in accordance with
the terms of the notice  delivered to the Company.  If a determination  has been
made pursuant to this Section 7(b) that the opinion of counsel for the holder is
not  reasonably  satisfactory  to the Company,  the Company  shall so notify the
holder  promptly  after  such   determination   has  been  made.  The  foregoing
notwithstanding,  this  Warrant or such  Warrant  Shares may, as to such federal
laws, be offered,  sold or otherwise disposed of in accordance with Rule 144 and
144A under the Act,  provided  that the Company shall have been  furnished  with
such  information as the Company may reasonably  request to provide a reasonable
assurance  that the  provisions of Rule 144 and 144A have been  satisfied.  Each
certificate  representing  this Warrant or the Warrant  Shares thus  transferred
(except  a  transfer  pursuant  to  Rule  144)  shall  bear a  legend  as to the
applicable  restrictions on  transferability  in order to ensure compliance with
such laws,  unless in the  aforesaid  opinion of counsel  for the  holder,  such
legend is not required in order to ensure compliance with such laws. The Company
may issue stop transfer  instructions to its transfer agent or, if acting as its
own transfer  agent,  the Company may stop transfer on its corporate  books,  in
connection with such restrictions.

         8.       Rights as Stockholders; Information.

         No  holder  of this  Warrant,  as such,  shall be  entitled  to vote or
receive  dividends  or be  deemed  the  holder  of  Common  Stock  or any  other
securities  of the Company  which may at any time be  issuable  on the  exercise
hereof for any  purpose,  nor shall  anything  contained  herein be construed to
confer  upon the  holder  of this  Warrant,  as  such,  any of the  rights  of a
stockholder  of the  Company  or any  right  to  vote  for the  election  of the
directors or upon any matter  submitted to stockholders at any meeting  thereof,
or to receive notice of meetings, or to receive dividends or subscription rights
or  otherwise,  until this  Warrant  shall have been  exercised  and the Warrant
Shares  purchasable upon the exercise hereof shall have become  deliverable,  as
provided herein. The foregoing notwithstanding, the Company will transmit to the
holder of this Warrant such information,  documents and reports as are generally
distributed  to the  holders  of any class or series  of the  securities  of the
Company concurrently with the distribution thereof to the stockholders.

                                      -10-
<PAGE>

         9.       Registration Rights

         9.1      Demand Registration Rights

                  a. The  Company  covenants  and agrees  that at any time after
receipt of a written request (a "Demand Registration Request") from holder(s) of
Warrants and/or Warrant Shares (collectively,  the "Securityholders") holding at
least twenty-five  percent (25%) of the Registrable  Securities not already sold
pursuant  to this  Section  9 or Rule 144  under  the  Act,  stating  that  such
Securityholders  desire and intend to have the Company register all or a portion
of the Warrant  Shares then  outstanding  or  issuable  pursuant to  unexercised
Warrants (the  "Registrable  Securities")  for sale, then the Company shall: (i)
promptly  deliver  written  notice  (the  "Registration  Notice")  to all  other
Securityholders of the Company's receipt of such registration request; (ii) file
with the SEC,  within  forty-five  (45)  days of  delivery  of the  Registration
Notice,  a  registration  statement  on  Form  S-3,  or any  successor  form  of
registration to such form, or, if the Company is ineligible therefore, Form S-1,
or any successor form of  registration  to such form, for an offering to be made
covering all of the Registrable Securities;  (iii) use its best efforts to cause
such registration  statement to be declared effective within ninety (90) days of
delivery of the Registration Notice; and (iv) use its best efforts to cause such
registration  statement to become  effective under the Act and remain  effective
for six (6)  months  or such  shorter  period  as may be  required  if all  such
Registrable  Securities covered by such registration statement are sold prior to
the expiration of such six (6)-month period; provided, however, that the Company
shall be obligated to effect only one such registration pursuant to this Section
9.1. For purposes of this Section 9.1(a), a registration  shall not be deemed to
have  been  effected  unless  a  registration   statement   including  at  least
eighty-five  percent (85%) of the  Registrable  Shares  requested to be included
therein has been  declared  effective  and,  subject to Section  9.3(b)  hereof,
remained  effective for a period of six (6) months (or such shorter period as is
permitted in clause (iv) of the first sentence of this Section 9.1(a)).

                  b. The foregoing Section 9.1(a) notwithstanding,  in the event
of an  underwritten  offering  pursuant to this  Section  9.1,  if the  managing
underwriter of such offering shall advise the  Securityholders  in writing that,
in its  opinion,  the  distribution  of a  specified  portion of the  securities
requested to be included in the registration  would materially  adversely affect
the  distribution of such  securities by increasing the aggregate  amount of the
offering  in excess of the  maximum  amount of  securities  which such  managing
underwriter  believes can reasonably be sold in the  contemplated  distribution,
then the securities to be included in the  registration  shall be reduced in the
following  order: (i) first,  securities  proposed to be included by the Company
and  securities  that  are not  Registrable  Securities  shall  be  excluded  as
determined  by the  Company  and (ii)  second,  Registrable  Securities  will be
excluded  pro rata  among  all of the  Registrable  Securities  requested  to be
included therein. For purposes of this Section 9.1, the Securityholders who have
requested  registration  of Common  Stock to be  acquired  upon the  exercise of
Warrants not theretofore exercised shall furnish the Company with an undertaking
that they or the  underwriters  or other  persons to whom such  Warrants will be
transferred  have undertaken to exercise such Warrants and to sell,  transfer or
otherwise  dispose of the Shares received upon exercise of such Warrants in such
registration.

                                      -11-
<PAGE>

         9.2      Incidental Registration

                  a. Subject to Section 9.2(b) below, the Company  covenants and
agrees that in the event the Company  proposes after the Date of Grant to file a
registration  statement  under  the  Act  with  respect  to any  of  its  equity
securities  (other than pursuant to registration  statements on Form S-4 or Form
S-8 or any successor or similar forms and other than  registrations  pursuant to
Section 9.1 hereof),  whether or not for its own account, then the Company shall
give written notice of such proposed filing to all Securityholders promptly (and
in any event at least twenty (20) days before the anticipated filing date). Such
notice  shall  offer to such  Securityholders,  together  with  others  who have
similar rights,  the opportunity to include in such registration  statement such
number of  Registrable  Securities as they may request  (other than  Registrable
Securities already registered pursuant to a Shelf Registration  Statement).  The
Company shall direct and use its  reasonable  best efforts to cause the managing
underwriter  of a proposed  underwritten  offering  (unless  the  offering is an
underwritten  offering of a class of the Company's equity  securities other than
Common  Stock and the  managing  underwriter  has advised the Company in writing
that,  in its  opinion,  the  inclusion  in such  offering of Common Stock would
materially  adversely  affect the  distribution  of such offering) to permit the
holders of Registrable  Securities  requested to be included in the registration
to include such Registrable  Securities in the proposed offering and the Company
shall use its reasonable best efforts to include such Registrable  Securities in
such  proposed  offering  on the  same  terms  and  conditions  as  any  similar
securities of the Company included therein. If the offering of which the Company
gives  notice is a public  offering  involving  an  underwriter,  the right of a
Securityholder to registration pursuant to this Section 9.2 shall be conditioned
upon  (i)  such  Securityholder's  participation  in such  underwriting  and the
inclusion of the Registrable Securities to be sold by such Securityholder in the
underwriting and (ii) such  Securityholder  executing an underwriting  agreement
entered  into by the  Company  which  includes  customary  terms and  conditions
relating to sales by shareholders. The foregoing notwithstanding, in the case of
a  firm  commitment  offering  on  underwriting  terms  appropriate  for  such a
transaction,  other than a registration requested by Securityholders pursuant to
Section 9.1, if any such  managing  underwriter  of  recognized  standing  shall
advise the Company and the Securityholders in writing that, in its opinion,  the
distribution  of all  or a  specified  portion  of  the  Registrable  Securities
requested to be included in the  registration  concurrently  with the securities
being  registered  by  the  Company  would   materially   adversely  affect  the
distribution  of such  securities  by  increasing  the  aggregate  amount of the
offering  in excess of the  maximum  amount of  securities  which such  managing
underwriter  believes can reasonably be sold in the  contemplated  distribution,
then  the  securities  to be  included  in a  registration  which  is a  primary
underwritten offering on behalf of the Company shall be reduced in the following
order: (i) first,  Registrable Securities and such other securities requested to
be included by holders of such other  securities  shall be excluded pro rata and
(ii) second the  securities  the Company  proposes to include  therein  shall be
excluded.

                  b. In the event  that a holder  or  holders  of the  Company's
securities (other than a Securityholder or Securityholders)  requests,  pursuant
to  rights  granted  to  such  holder  or  holders,  that  the  Company  file  a
registration statement for the public offering of securities and the Company and
the other holders of the Company's  securities  (including the  Securityholders)
who have rights to be included in such  registration,  request to be included in

                                      -12-
<PAGE>>
such registration and the managing underwriter of such offering shall advise the
Company  and the holders  requesting  inclusion  in the  offering  that,  in its
opinion,  the distribution of a specified portion of the securities requested to
be  included  in  the  registration   would  materially   adversely  affect  the
distribution  of such  securities  by  increasing  the  aggregate  amount of the
offering  in excess of the  maximum  amount of  securities  which such  managing
underwriter  believes can  reasonably be sold in the  contemplated  distribution
then, the securities to be included in the registration  shall be reduced in the
following order:  (i) first, any securities  requested to be included therein by
the  holders  of such other  securities  in such a manner as  determined  by the
Company,  (ii) second  Registrable  Securities shall be excluded pro rata, (iii)
securities  proposed to be included by the Company  shall be excluded  and, (iv)
fourth,  securities  requested  to be included  therein by the holder or holders
making the initial  request for the  registration.  For purposes of this Section
9.2(b),  the Company  agrees to request for inclusion in the  registration  only
that number of securities that the Company  intends,  in good faith, to sell, if
all such securities so requested by the Company were permitted to be included by
the managing underwriter in such registration and sold pursuant thereto.

         9.3      Company's Obligations

                  a.  In  connection   with  the   registration  of  Registrable
Securities on behalf of the holders thereof (such Securityholders being referred
to herein as "Sellers") in accordance with Section 9.1 or Section 9.2 above, and
in addition to its other  obligations  under this Section 9, the Company  agrees
to:

                           (i)      with  respect to any  registration  pursuant
to  Section  9.1(a)  or  Section  9.1(b),  prepare  and  file  with  the  SEC  a
registration  statement on the form  specified in such section,  with respect to
the Registrable Securities to be registered pursuant to such section, and to use
its best  efforts  to cause  such  registration  statement  to become and remain
effective as provided in such section;

                           (ii)  enter  into  a  cross-indemnity  agreement,  in
customary form, with each underwriter, if any, and each
Seller;

                           (iii)    subject  to the  provisions  of Section  9.1
and Section 9.2 regarding reductions in Registrable Securities to be included in
a registration,  include in the  registration  statement filed with the SEC, the
Registrable  Securities for which requests for registration  have been made (or,
in the  case of a  registration  under  Section  9.1(a),  all  such  Registrable
Securities),   promptly  after  filing  of  such  a  registration  statement  or
prospectus or any  amendments  or  supplements  thereto,  furnish to each Seller
copies  of  all  such  documents  filed  including,   if  requested,   documents
incorporated by reference in the registration statement,  and notify each Seller
of any stop order  issued or  threatened  by the SEC and use its best efforts to
prevent the entry of such stop order or to remove it if entered;

                           (iv) subject to Section 9.3(b), prepare and file with
the SEC such  amendments of and supplements to such  registration  statement and
the  prospectus  used in  connection  therewith as may be necessary to keep such
registration  statement effective with respect to a registration statement under

                                      -13-
<PAGE>

Section  9.1 or  Section  9.2,  for a period of six (6)  months or such  shorter
period as may be required  if all such  Registrable  Securities  covered by such
registration  statement  are sold prior to the  expiration of such period and to
otherwise  comply with the provisions of the Act with respect to the disposition
of all securities  covered by such registration  statement during such period in
accordance with the intended  methods of disposition by the Sellers set forth in
such registration statement;

                           (v) furnish to each Seller and each  underwriter,  if
any, without charge, such number of copies of the registration  statement,  each
amendment and supplement  thereto (in each case including all exhibits thereto),
the  prospectus  included  in  such  registration   statement   (including  each
preliminary  prospectus)  and such other documents as such Seller may reasonably
request in order to facilitate  the  disposition of the  Registrable  Securities
proposed to be sold by such Seller;

                           (vi) use its  reasonable  best efforts to register or
qualify such Registrable Securities under such other securities or Blue Sky laws
of such jurisdictions as any Seller or any such underwriter  reasonably requests
in writing and keep such  registrations or  qualifications in effect for so long
as such  registration  statement  remains  in effect and do any and all acts and
things which may be  reasonably  necessary or advisable to enable such Seller to
consummate the disposition in such  jurisdictions of the Registrable  Securities
owned by such Seller; provided,  however, that the Company shall not be required
to (A) qualify  generally to do business in any jurisdiction  where it would not
otherwise  be  required to qualify but for this  Subsection  9.3(a)(vi),  or (B)
consent to general service of process in any such jurisdiction;

                           (vii)  notify  each  Seller,   at  any  time  when  a
prospectus  relating to such Seller's  Registrable  Securities is required to be
delivered under the Act, of the occurrence of any event as a result of which the
prospectus included in such registration  statement contains an untrue statement
of a material  fact or omits to state any  material  fact  necessary to make the
statements  therein  not  misleading,  and as  soon  as  practicable  prepare  a
supplement or amendment to such  prospectus so that, as thereafter  delivered to
the purchasers of such Registrable Securities,  such prospectus will not contain
an  untrue  statement  of a  material  fact or omit to state any  material  fact
necessary to make the statements therein not misleading;

                           (viii) cause all such  Registrable  Securities  to be
listed  on any  Exchange  or NASDAQ on which  similar  securities  issued by the
Company are then listed;

                           (ix) provide a transfer  agent,  registrar  and CUSIP
number for all such Registrable  Securities not later than the effective date of
such registration statement;

                           (x) enter into such customary  agreements  (including
an  underwriting  agreement in customary  form) and take all such other  actions
that the Sellers or the  underwriters,  if any,  reasonably  request in order to
expedite or facilitate the disposition of such Registrable Securities;

                                      -14-
<PAGE>

                           (xi) make available for inspection by the Sellers and
their counsel, any underwriter participating in any disposition pursuant to such
registration  statement,  and any counsel retained by any such underwriter,  all
pertinent  financial  and  other  information  and  corporate  documents  of the
Company, and cause the Company's officers, directors and employees to supply all
information  reasonably requested by any such Seller,  underwriter or counsel in
connection with such registration statement;

                           (xii) with respect to any underwritten  offering, use
its reasonable best efforts to obtain a "cold comfort" letter from the Company's
independent  public  accountants  in customary form and covering such matters of
the type  customarily  covered by "cold  comfort"  letters as the Sellers or any
underwriter may reasonably request;

                           (xiii)  with  respect  to an  underwritten  offering,
obtain an opinion of counsel to the  Company,  addressed  to the Sellers and any
underwriter,  in customary  form and including  such matters as are  customarily
covered  by  such  opinions  in  underwritten  registered  offerings  of  equity
securities  as the  Sellers or any  underwriter  may  reasonably  request,  such
opinion to be reasonably satisfactory in form and substance to each Seller; and

                           (xiv)  otherwise  use its best efforts to comply with
all  applicable  rules and  regulations  of the SEC,  and make  available to its
Securityholders,  as soon  as  reasonably  practicable,  an  earnings  statement
covering the period of at least twelve (12) months  subsequent  to the effective
date of the registration  statement,  which earnings statement shall satisfy the
provisions of Section 11(a) of the Act and Rule 158 thereunder.

                  b. Any other  provisions  of this  Section 9  notwithstanding,
upon  receipt by the  Securityholders  of a written  notice  signed by the chief
executive  officer or chief  financial  officer of the Company to the effect set
forth below,  the Company shall not be obligated  during a reasonable  period of
time (not to exceed ninety (90) days) thereafter (i) to effect any registrations
pursuant  to  this  Section  9 or  (ii)  with  respect  to  an  effective  Shelf
Registration  Statement,  may suspend  the  effectiveness  of such  registration
statement, at any time at which, in the Company's reasonable judgment, (i) there
is a  development  involving  the  Company  or any of its  affiliates  which  is
material but which has not yet been publicly disclosed or (ii) sales pursuant to
the registration statement would materially and adversely affect an underwritten
public  offering for the account of the Company or any other material  financing
project or a proposed or pending  material merger or other material  acquisition
or material  business  combination  or  material  disposition  of the  Company's
assets,  to which the Company or any of its affiliates is, or is expected to be,
a party.  In the event a  registration  is  postponed  in  accordance  with this
Section  9.3(b),  (x) the Company must  (unless  otherwise  instructed  by those
holders who requested such registration) file the requested  registration within
nine (9) months  from the date the  Company  first  received  the request of the
holders, (y) the Company may not defer the filing of a requested registration or
suspend the  effectiveness of a Shelf  Registration  Statement  pursuant to this
Section 9.3(b) more than once in any eighteen  (18)-month  period, and (z) there
shall be added to any period  during  which the Company is  obligated  to keep a
registration  effective  the  number  of days for  which  the  registration  was
postponed pursuant to this Section 9.3(b).

                                      -15-
<PAGE>

                  c. The Company may require that each Seller, as a condition to
registering his, her or its Registrable  Securities pursuant hereto, furnish the
Company with such  information  regarding the  distribution  of the  Registrable
Securities  proposed  to be sold by such  Seller as the Company may from time to
time reasonably request in writing.

                  d. Each Seller  agrees  that,  upon receipt of any notice from
the  Company of the  occurrence  of any event of the kind  described  in Section
9.3(a)(vii)  above,  such Seller  shall  forthwith  discontinue  disposition  of
Registrable  Securities  pursuant to the  registration  statement  covering such
Registrable Securities until such Seller's receipt of copies of the supplemented
or amended  prospectus  contemplated  by Section  9.3(a)(vii)  above and,  if so
directed  by the  Company,  such  Seller  will  deliver to the  Company  (at the
Company's expense) all copies, other than permanent file copies in such Seller's
possession,  of the prospectus  covering such Registrable  Securities current at
the time of receipt of such notice. In the event the Company shall give any such
notice,  the period  mentioned in Section  9.3(a)(iv) above shall be extended by
the number of days  during the period from and  including  the date of giving of
such notice to and  including  the date when each Seller shall have received the
copies  of the  supplemented  or  amended  prospectus  contemplated  by  Section
9.3(a)(vii) above.

                  e. The  Company  shall  not file or permit  the  filing of any
registration  or  comparable  statement  which  refers to any  Seller by name or
otherwise as the Seller of any  securities of the Company  unless such reference
to such Seller is agreed to by the Seller or is specifically required by the Act
or any similar federal statute then in force.

         9.4  Fees  and  Expenses.   All  expenses  incident  to  the  Company's
performance  of or  compliance  with this Warrant shall be borne by the Company,
including without limitation all registration and filing fees, fees and expenses
relating  to filings  with any  Exchange  and/or  NASDAQ,  fees and  expenses of
compliance  with  securities  or  Blue  Sky  laws  in  jurisdictions  reasonably
requested by any Seller or underwriter pursuant to Section 9.3(a)(vi) (including
reasonable  fees and  disbursements  of  counsel  in  connection  with  Blue Sky
qualifications of the Registrable Securities), all word processing,  duplicating
and printing expenses,  messenger and delivery expenses,  fees and disbursements
of counsel for the Company  and one (1)  counsel  for the Sellers  (selected  by
those  Sellers  owning  a  majority  of the  Registrable  Securities),  fees and
expenses  of  independent  public  accountants  (including  the  expenses of any
special  audit  or  "cold  comfort"  letters  required  by or  incident  to such
performance),   fees  and  expenses  of   underwriters   (excluding   discounts,
commissions or fees of underwriters, selling brokers, dealer managers or similar
securities industry professionals  attributable directly to the securities being
registered,  which  discounts,  commissions or fees with respect to any Seller's
respective  shares shall be paid by such  Seller),  all the  Company's  internal
expenses  (including,  without  limitation,  all  salaries  and  expenses of its
officers and employees  performing legal or accounting  duties),  the expense of
any  annual  audit,  the  expense of any  liability  insurance  (if the  Company
determines  to  obtain  such  insurance),  the fees  and  expenses  incurred  in
connection  with the listing of the  securities to be registered on any Exchange
and/or  NASDAQ on which such  securities  issued by the Company are then listed,
the reasonable  fees and expenses of any special experts  (including  attorneys)
retained by the Company (if it so desires) in connection with such registration,
and fees and  expenses  of other  persons  retained  by the  Company  (all  such
expenses being herein called "Registration Expenses").

                                      -16-
<PAGE>

         9.5  Participation.  In connection  with the  preparation and filing of
each  registration  statement  under the Act  pursuant  to this  Section  9, the
Company  shall  give  the  Sellers  under  such  registration  statement,  their
underwriters,  if  any,  and  their  respective  counsel  and  accountants,  the
opportunity to participate in the  preparation of such  registration  statement,
each  prospectus  included  therein  or filed with the SEC,  and each  amendment
thereof or  supplement  thereto,  and will give each of them such  access to its
books and records and such  opportunities to discuss the business of the Company
with its officers and the independent  public accountants who have certified its
financial statements as shall be necessary,  in the opinion of such Sellers' and
such underwriters'  respective  counsel,  to conduct a reasonable  investigation
within the meaning of the Act.

         9.6      Indemnification

                  a. In the event of any  registration  of any securities of the
Company under the Act, the Company  shall,  and hereby does,  indemnify and hold
harmless in the case of any registration statement filed pursuant to Section 9.1
or Section 9.2 above, the Seller of any Registrable  Securities  covered by such
registration  statement,  its directors,  officers,  employees and agents,  each
other person who  participates as an underwriter in the offering or sale of such
Registrable  Securities and each other person,  if any, who controls such Seller
or any such  underwriter  within the  meaning  of the Act  against  any  losses,
claims,  damages, or liabilities (or actions or proceedings whether commenced or
threatened in respect  thereof),  joint or several,  to which such Seller or any
such  director  or officer or employee or agent or  underwriter  or  controlling
person may become  subject under the Act or  otherwise,  insofar as such losses,
claims, damages, or liabilities (or actions or proceedings, whether commenced or
threatened,  in  respect  thereof)  arise  out of or are based  upon any  untrue
statement or alleged  untrue  statement of any  material  fact  contained in any
registration  statement under which such Registrable  Securities were registered
under  the  Act,  any  preliminary  prospectus,   final  prospectus  or  summary
prospectus  contained therein,  or any amendment or supplement  thereto,  or any
omission or alleged  omission to state  therein a material  fact  required to be
stated therein or necessary to make the statements  therein not misleading,  and
the  Company  shall  reimburse  such  Seller  and each such  director,  officer,
employee,  agent,  underwriter and controlling person for any legal or any other
expenses  reasonably  incurred  by  them in  connection  with  investigating  or
defending any such loss,  claim,  liability,  action,  or proceeding;  provided,
however,  that the  Company  shall not be liable in any such case to the  extent
that any such loss, claim, damage,  liability (or action or proceeding,  whether
commenced or  threatened  in respect  thereof),  or expense  arises out of or is
based upon an untrue  statement  or alleged  untrue  statement  or  omission  or
alleged  omission  made in such  registration  statement,  any such  preliminary
prospectus,  final prospectus,  summary prospectus,  amendment, or supplement in
reliance  upon and in  conformity  with  written  information  furnished  to the
Company by such Seller for the express purpose of use in the preparation thereof
and, provided, further, that the Company shall not be liable in any such case to
the  extent  that  any  such  loss,  claim,  damage,  liability  (or  action  or
proceeding,  whether commenced or threatened,  in respect  thereof),  or expense
arises  out of such  person's  failure  to  send  or  give a copy  of the  final
prospectus,  as the same may be then  supplemented  or amended,  within the time
required  by the Act to the  person  asserting  an untrue  statement  or alleged
untrue  statement or omission or alleged  omission if such statement or omission
was  corrected in such final  prospectus.  Such  indemnity  shall remain in full
force and effect  regardless of any  investigation  made by or on behalf of such
Seller  or  any  such  director,   officer,   employee,  agent,  underwriter  or
controlling person and shall survive the transfer of such Registrable Securities
by such Seller.

                                      -17-
<PAGE>

                  b. In the event  that the  Company  includes  any  Registrable
Securities of a prospective Seller in any registration  statement filed pursuant
to Section 9.1 or Section 9.2 above,  such prospective  Seller shall, and hereby
does,  indemnify  and  hold  harmless  the  Company,  its  directors,  officers,
employees and agents,  each other person who  participates  as an underwriter in
the offering or sale of such  Registrable  Securities and each other person,  if
any, who controls the Company or any such underwriter  within the meaning of the
Act  against  any  losses,  claims,  damages,  or  liabilities  (or  actions  or
proceedings  whether  commenced  or  threatened  in respect  thereof),  joint or
several,  to which the  Company or any such  director  or officer or employee or
underwriter or controlling person may become subject under the Act or otherwise,
insofar  as  such  losses,  claims,  damages,  or  liabilities  (or  actions  or
proceedings,  whether commenced or threatened,  in respect thereof) arise out of
or are based  upon any  untrue  statement  or alleged  untrue  statement  of any
material  fact  contained  in  any  registration   statement  under  which  such
Registrable   Securities  were   registered   under  the  Act,  any  preliminary
prospectus,  final prospectus or summary prospectus  contained  therein,  or any
amendment or supplement  thereto,  or any omission or alleged  omission to state
therein a material fact  required to be stated  therein or necessary to make the
statements  therein not misleading,  and such prospective Seller shall reimburse
the Company and any such  director,  officer,  employee,  agent,  underwriter or
controlling  person for any legal or any other expenses  reasonably  incurred by
them in  connection  with  investigating  or  defending  any such  loss,  claim,
liability,  action,  or  proceeding  if, and only if, such  statement or alleged
statement  or omission  or alleged  omission  was made in  reliance  upon and in
conformity  with  written  information  furnished  to  the  Company  through  an
instrument duly executed by such Seller specifically  stating that it is for use
in the preparation of such registration statement, preliminary prospectus, final
prospectus, summary prospectus,  amendment, or supplement. In no event shall the
liability of any Seller hereunder be greater in amount than the dollar amount of
the proceeds received by such Seller upon the sale of the Registrable Securities
giving rise to such indemnification  obligation.  Such indemnity shall remain in
full force and effect  regardless of any  investigation  made by or on behalf of
the Company or any such  director,  officer,  employee,  agent,  underwriter  or
controlling person and shall survive the transfer of such Registrable Securities
by such Seller.

                  c. The Company shall be entitled to receive  indemnities  from
underwriters,  selling brokers, dealer managers, and similar securities industry
professionals  participating  in the distribution to the same extent as provided
above with  respect  to  information  so  furnished  in writing by such  persons
specifically for inclusion in any prospectus or registration statement.

                  d. Promptly after receipt by an indemnified party of notice of
the  commencement  of any action or proceeding  involving a claim referred to in
this Section 9.6, such indemnified party shall, if a claim in respect thereof is
to be made against an indemnifying  party,  give written notice to the latter of
the  commencement  of such action;  provided,  however,  that the failure of any

                                      -18-
<PAGE>

indemnified  party to give  notice as  provided  herein  shall not  relieve  the
indemnifying  party of its obligations under the preceding  subdivisions of this
Section  9.6,  except to the  extent  that the  indemnifying  party is  actually
prejudiced  by such failure to give  notice.  In case any such action is brought
against an indemnified  party,  unless in such  indemnified  party's  reasonable
judgment a conflict  of  interest  between  such  indemnified  and  indemnifying
parties  may exist in respect of such  claim,  the  indemnifying  party shall be
entitled to participate in and to assume the defense  thereof,  jointly with any
other indemnifying party similarly notified, to the extent that the indemnifying
party may wish, with counsel reasonably  satisfactory to such indemnified party,
and after notice from the indemnifying  party to such  indemnified  party of its
election so to assume the defense thereof,  the indemnifying  party shall not be
liable to such  indemnified  party for any legal or other expenses  subsequently
incurred  by the  latter in  connection  with the  defense  thereof  other  than
reasonable costs of  investigation.  If, in the indemnified  party's  reasonable
judgment a conflict  of  interest  between  such  indemnified  and  indemnifying
parties may exist in respect of such claim, the indemnified party may assume the
defense of such claim,  jointly with any other indemnified party that reasonably
determines such conflict of interest to exist, and the indemnifying  party shall
be liable to such indemnified parties for the reasonable legal fees and expenses
of one  counsel  for  all  such  indemnified  parties  and  for  other  expenses
reasonably  incurred  in  connection  with the defense  thereof  incurred by the
indemnified  party.  No  indemnifying  party  shall,  without the consent of the
indemnified party, consent to entry of any judgment or enter into any settlement
of any such action which does not include as an  unconditional  term thereof the
giving by the claimant or plaintiff to such indemnified  party of a release from
all liability, or a covenant not to sue, in respect of such claim or litigation.
No  indemnified  party shall  consent to entry of any judgment or enter into any
settlement  of any such  action  the  defense  of which has been  assumed  by an
indemnifying party without the consent of such indemnifying party.

                  e.  Indemnification and contribution similar to that specified
in this  Section  9.6  (with  appropriate  modifications)  shall be given by the
Company and each  Seller  with  respect to any  required  registration  or other
qualification  of  Registrable  Securities  under  any  Federal  or state law or
regulation of any governmental authority, other than the Act.

                  f. The  indemnification  required by this Section 9.6 shall be
made by  periodic  payments  of the  amount  thereof  during  the  course of the
investigation  or defense,  as and when bills are  received  or  expense,  loss,
damage or liability is incurred.

                  g. If the  indemnification  provided  for in this  Section 9.6
from the indemnifying  party is unavailable to an indemnified party hereunder in
respect of any losses,  claims,  damages,  liabilities,  or expenses referred to
herein,  then the indemnifying  party, in lieu of indemnifying  such indemnified
party,  shall contribute to the amount paid or payable by such indemnified party
as a result  of  losses,  claims,  damages,  liabilities,  or  expenses  in such
proportion as is appropriate  to reflect the relative fault of the  indemnifying
party and  indemnified  party in connection  with the actions which  resulted in
such losses,  claims,  damages,  liabilities,  or expenses, as well as any other
relevant equitable considerations. The relative fault of such indemnifying party
and  indemnified  party shall be determined by reference to, among other things,
whether any action in question, including any untrue or alleged untrue statement
of a material fact or omission or alleged omission to state a material fact, has

                                      -19-
<PAGE>

been made by, or relates to information  supplied by, such indemnifying party or
indemnified  party,  and the  parties'  relative  intent,  knowledge,  access to
information,  and opportunity to correct or prevent such action. The amount paid
or payable by a party as a result of the losses, claims,  damages,  liabilities,
and  expenses  referred  to above  shall be deemed to include any legal or other
fees or  expenses  reasonably  incurred  by such  party in  connection  with any
investigation  or  proceeding.  In no event  shall the  liability  of any Seller
hereunder be greater in amount than the dollar  amount of the proceeds  received
by such Seller upon the sale of the Registrable  Securities  giving rise to such
contribution obligation.  The parties hereto agree that it would not be just and
equitable if contribution pursuant to this Section 9.6(g) were determined by pro
rata  allocation or by any other method of  allocation  which does not take into
account the  equitable  considerations  referred to in this Section  9.6(g).  No
person  guilty of  fraudulent  misrepresentation  (within the meaning of Section
11(f) of the Act) shall be  entitled to  contribution  from any person or entity
who was not guilty of such fraudulent misrepresentation.

         9.7      Assignment of Rights; Termination.

         The  rights  granted  under  this  Section  9 may  be  assigned  to the
transferee of any of the  Registrable  Securities and will terminate on the five
(5) year anniversary of the Expiration Date.
10.  Representations and Warranties.

                  The  Company  represents  and  warrants  to the holder of this
Warrant as follows:

                  a. This Warrant has been duly  authorized  and executed by the
Company and is a valid and binding  obligation  of the  Company  enforceable  in
accordance with its terms,  subject to laws of general  application  relating to
bankruptcy,  insolvency  and the  relief  of  debtors  and the  rules  of law or
principles at equity governing specific performance, injunctive relief and other
equitable remedies;

                  b. The Warrant  Shares have been duly  authorized and reserved
for  issuance  by the Company  and,  when  issued in  accordance  with the terms
hereof, will be validly issued, fully paid and nonassessable;

                  c.  The  rights,  preferences,   privileges  and  restrictions
granted to or imposed upon the Common  Stock and the holders  thereof are as set
forth in the certificate of incorporation of the Company, as amended to the Date
of Grant (as so amended,  the "Charter"),  a true and complete copy of which has
been delivered to the original holder of this Warrant;

                  d. The execution and delivery of this Warrant are not, and the
issuance of the Warrant Shares upon exercise of this Warrant in accordance  with
the terms  hereof will not be,  inconsistent  with the Charter or by-laws of the
Company,  do  not  and  will  not  contravene,  in  any  material  respect,  any
governmental  rule or regulation,  judgment or order  applicable to the Company,
and do not and will  not  conflict  with or  contravene  any  provision  of,  or
constitute  a  default  under,  any  indenture,   mortgage,  contract  or  other
instrument  of which the  Company  is a party or by which it is bound or require
the consent or approval of, the giving of notice to, the  registration or filing

                                      -20-
<PAGE>

with or the taking of any action in  respect  of or by,  any  Federal,  state or
local government  authority or agency or other person,  except for the filing of
notices  pursuant to federal and state  securities  laws,  which filings will be
effected by the time required thereby;

                  e. There are no  actions,  suits,  audits,  investigations  or
proceedings pending or, to the knowledge of the Company,  threatened against the
Company in any court or before any governmental  commission,  board or authority
which,  if  adversely  determined,  will have a material  adverse  effect on the
ability of the Company to perform its obligations under this Warrant;

                  f. Intentionally omitted.

                  g. Intentionally omitted.

                  h. The Company is not subject to any obligation (contingent or
otherwise)  to  repurchase  or  otherwise  acquire  or retire  any shares of its
capital stock or any security  convertible  into or exchangeable  for any of its
capital stock.

         10.      Modification and Waiver.

         This  Warrant  and  any  provision  hereof  may  be  changed,   waived,
discharged  or terminated  only by an instrument in writing  signed by the party
against which enforcement of the same is sought.

         11.      Notices.

         Unless otherwise specifically provided herein, all communications under
this Warrant shall be in writing and shall be deemed to have been duly given (i)
on the date of service if served personally on the party to whom notice is to be
given,  (ii) on the day of transmission  if sent by facsimile  transmission to a
number  provided  to a party  specifically  for such  purposes,  and  telephonic
confirmation of receipt is obtained  promptly after  completion of transmission,
(iii) on the day after delivery to Federal Express or similar overnight courier,
or (iv) on the fifth day after mailing, if mailed to the party to whom notice is
to be given, by first class mail, registered or certified,  postage prepaid, and
properly addressed, return receipt requested, to each such holder at its address
as shown on the books of the Company or to the Company at the address  indicated
therefor on the signature page of this Warrant.  Any party hereto may change its
address for purposes of this Section 11 by giving the other party written notice
of the new address in the manner set forth herein.

                                      -21-
<PAGE>

         12.      Binding Effect on Successors.

         This  Warrant  shall be binding  upon any  corporation  succeeding  the
Company by merger,  consolidation or acquisition of all or substantially  all of
the Company's assets,  and all of the obligations of the Company relating to the
Common Stock  issuable  upon the exercise or  conversion  of this Warrant  shall
survive the exercise,  conversion and termination of this Warrant and all of the
covenants  and  agreements  of the  Company  shall  inure to the  benefit of the
successors  and assigns of the holder  hereof.  The Company will, at the time of
the exercise or conversion of this Warrant, in whole or in part, upon request of
the holder  hereof but at the  Company's  expense,  acknowledge  in writing  its
continuing obligation to the holder hereof in respect of any rights to which the
holder hereof shall continue to be entitled after such exercise or conversion in
accordance with this Warrant; provided, that the failure of the holder hereof to
make any such request shall not affect the continuing  obligation of the Company
to the holder hereof in respect of such rights.

         13.      Lost Warrants or Stock Certificates.

         The  Company  covenants  to the holder  hereof  that,  upon  receipt of
evidence reasonably satisfactory to the Company of the loss, theft,  destruction
or mutilation of this Warrant or any stock  certificate  and, in the case of any
loss, theft or destruction,  upon receipt of an executed lost securities bond or
indemnity  reasonably  satisfactory  to the Company,  or in the case of any such
mutilation upon surrender and cancellation of such Warrant or stock certificate,
the Company  will make and deliver a new Warrant or stock  certificate,  of like
tenor,  in lieu of the lost,  stolen,  destroyed or  mutilated  Warrant or stock
certificate.

         14.      Descriptive Headings.

         The descriptive  headings of the several paragraphs of this Warrant are
inserted for convenience only and do not constitute a part of this Warrant.

         15. Governing Law. The validity, interpretation and performance of this
Warrant shall be governed by, and construed in accordance  with, the laws of the
State of California  applicable to contracts  made and to be performed  entirely
within such State,  regardless of the law that might be applied under principles
of conflicts of law.

         16. Survival of Representations, Warranties and Agreements. Each of the
respective  representations  and warranties of the Company and the holder hereof
contained  herein shall survive the Date of Grant, the exercise or conversion of
this  Warrant (or any part  hereof) and the  termination  or  expiration  of any
rights hereunder.  Each of the respective  agreements of each of the Company and
the holder hereof  contained herein shall survive  indefinitely  until, by their
respective terms, they are no longer operative.  Without limiting the generality
of the foregoing sentence,  the registration rights contained in Section 9 above
shall  survive the exercise or  conversion  of this Warrant (or any part hereof)
and the termination or expiration of any other rights hereunder.

                                      -22-
<PAGE>
         17.      Remedies.

         In case any one (1) or more of the covenants and  agreements  contained
in this Warrant shall have been  breached,  the holders hereof (in the case of a
breach by the  Company),  or the  Company (in the case of a breach by a holder),
may proceed to protect and enforce  their or its rights either by suit in equity
and/or by action at law, including, but not limited to, an action for damages as
a result of any such breach  and/or an action for  specific  performance  of any
such covenant or agreement contained in this Warrant.

         18.      Acceptance.

         Receipt  of  this  Warrant  by  the  holder  hereof  shall   constitute
acceptance of and agreement to the foregoing terms and conditions.

         19.      No Impairment of Rights.

         The Company  will not, by amendment of its Charter or through any other
means,  avoid or seek to avoid the observance or performance of any of the terms
of this Warrant,  but will at all times in good faith assist in the carrying out
of all such terms and in the taking of all such  action as may be  necessary  or
appropriate in order to protect the rights of the holder of this Warrant against
material impairment.

         20. Amendment.  This Warrant may be amended by written agreement of the
Company  and  holders  of  65%  of  the  Warrant  Shares,   collectively  on  an
as-exercised  basis,  and such amendment shall be binding on all holders of this
Warrant or Warrant Shares.

[Signature page follows.]



                                      -23-
<PAGE>



IN WITNESS  WHEREOF,  the Company has caused this  Warrant to be executed on its
behalf by one of its officers thereunto duly authorized.

IMMUNOMEDICS, INC.

         By:   /s/ David M. Goldenberg
               Name:  David M. Goldenberg
               Title: Chairman and Chief Executive Officer
               Address:

Dated:  as of December 16, 1999




                                      -24-
<PAGE>



                                    EXHIBIT A
                               NOTICE OF EXERCISE

To:      IMMUNOMEDICS, INC.

1. The  undersigned  hereby  elects to purchase  _____ shares of Common Stock of
______________________  pursuant  to the  terms  of the  attached  Warrant,  and
tenders herewith payment of the purchase price of such shares in full.

2. Please issue a certificate or  certificates  representing  said shares in the
name of the undersigned or in such other name or names as are specified below:

- ------------------------------


- ------------------------------
               (Name)

- ------------------------------
               (Address)

3. The undersigned  represents that the aforesaid  shares are being acquired for
the account of the  undersigned  for  investment  and not with a view to, or for
resale in connection with, the distribution thereof and that the undersigned has
no present  intention  of  distributing  or reselling  such  shares.  In support
thereof,  the  undersigned has executed an Investment  Representation  Statement
attached hereto as Schedule 1.

_________________________ (Signature)
__________________(Date)

4.  Please  issue a new  Warrant  for the  unexercised  portion of the  attached
Warrant in the name of the  undersigned  or in such  other name as is  specified
below:

- ------------------------------------------


Date: _________________________
                                                  By:

(Warrantholder) _________________________


Name: (Print) ______________________________

                                                  Its:

- --------------------------------------

                                      -25-
<PAGE>



                                   Schedule 1
                       INVESTMENT REPRESENTATION STATEMENT


Purchaser:  _______________________________
Company:    IMMUNOMEDICS, INC.
Security:   Common Stock
Amount:     _____________________________
Date:       _____________________________

In connection with the purchase of the above-listed securities (the "Registrable
Securities"),  the undersigned  (the  "Purchaser")  represents to the Company as
follows:

(a) The  Purchaser  is aware of the  Company's  business  affairs and  financial
condition, and has acquired sufficient information about the Company to reach an
informed and knowledgeable decision to acquire the Registrable  Securities.  The
Purchaser  is  purchasing  the  Registrable  Securities  for its own account for
investment purposes only and not with a view to, or for the resale in connection
with, any "distribution"  thereof for purposes of the Registrable Securities Act
of 1933, as amended (the "Act").


(b) The Purchaser  understands  that the  Registrable  Securities  have not been
registered under the Act in reliance upon a specific exemption therefrom,  which
exemption  depends  upon,  among  other  things,  the bona  fide  nature  of the
Purchaser's  investment  intent as expressed  herein.  In this  connection,  the
Purchaser  understands  that,  in the  view of the  Registrable  Securities  and
Exchange  Commission  ("SEC"),  the  statutory  basis for such  exemption may be
unavailable  if the  Purchaser's  representation  was  predicated  solely upon a
present intention to hold these  Registrable  Securities for the minimum capital
gains period  specified  under  applicable tax laws, for a deferred sale, for or
until an increase or decrease in the market price of the Registrable Securities,
or for a period of one year or any other fixed period in the future.


(c) The Purchaser  further  understands that the Registrable  Securities must be
held  indefinitely  unless  subsequently  registered  under the Act or unless an
exemption from registration is otherwise available.  In addition,  the Purchaser
understands that the certificate  evidencing the Registrable  Securities will be
imprinted with the legend referred to in the Warrant under which the Registrable
Securities are being purchased.


(d) The Purchaser is aware of the  provisions of Rule 144 and 144A,  promulgated
under the Act, which, in substance,  permit limited public resale of "restricted
securities" acquired,  directly or indirectly,  from the issuer thereof (or from
an  affiliate  of  such  issuer),  in  a  non-public  offering  subject  to  the
satisfaction  of certain  conditions,  if  applicable,  including,  among  other
things:  The availability of certain public  information about the Company,  the
resale  occurring  not less than one (1) year after the party has  purchased and
paid for the  securities to be sold;  the sale being made through a broker in an
unsolicited  "broker's  transaction" or in  transactions  directly with a market
maker (as said term is defined under the Registrable  Securities Exchange Act of
1934, as amended) and the amount of securities being sold during any three-month
period not exceeding the specified limitations stated therein.

                                      -26-
<PAGE>


(e) The  Purchaser  further  understands  that at the time it wishes to sell the
Registrable  Securities  there may be no public market upon which to make such a
sale, and that, even if such a public market then exists, the Company may not be
satisfying the current public information requirements of Rule 144 and 144A, and
that, in such event, the Purchaser may be precluded from selling the Registrable
Securities  under Rule 144 and 144A even if the one-year  minimum holding period
had been satisfied.


(f) The Purchaser further  understands that in the event all of the requirements
of Rule 144 and 144A are not satisfied,  registration under the Act,  compliance
with Regulation A, or some other  registration  exemption will be required;  and
that,  notwithstanding the fact that Rule 144 is not exclusive, the Staff of the
SEC has expressed its opinion that persons  proposing to sell private  placement
securities  other than in a registered  offering and otherwise  than pursuant to
Rule 144 will  have a  substantial  burden  or  proof  in  establishing  that an
exemption from registration is available for such offers or sales, and that such
persons and their respective  brokers who participate in such transactions do so
at their own risk.

Purchaser:___________________





                                      -27-
<PAGE>


                                   EXHIBIT 5.1

January 10, 2000

Immunomedics, Inc.
300 American Road
Morris Plains, New Jersey 07950

Gentlemen and Ladies:

         You have requested our opinion,  as counsel for  Immunomedics,  Inc., a
Delaware  corporation  (the  "Company"),   in  connection  with  a  Registration
Statement on Form S-3 (the "Registration Statement") under the Securities Act of
1933  (the  "Act"),  filed by the  Company  with  the  Securities  and  Exchange
Commission (the "Commission").

         The  Registration  Statement  relates to (a) the  offering by a selling
stockholder of up to 75,000 shares (the "Shares") of the Company's common stock,
$.01 par value per share (the "Common Stock"),  issuable from time to time, upon
exercise  of a  warrant  granted  by the  Company  to  Sutro & Co.  Incorporated
("Sutro")  and (b) the  offering  by a group of  selling  stockholders  of up to
2,500,000  Shares purchased from the Company pursuant to a Common Stock Purchase
Agreement

         In the  preparation  of our opinion,  we have examined (1) the Restated
Certificate of Incorporation of the Company, as amended to date, (2) the By-Laws
of the  Company,  in effect on the date  hereof,  (3) minutes of meetings of the
Company's Board of Directors,  as made available to us by executive  officers of
the Company, (4) a certificate from an executive officer of the Company, (5) the
Registration  Statement,  (6) the Common Stock Purchase  Agreement,  dated as of
December 14,  1999,  as amended  (the  "Agreement")  and (7) the form of Sutro's
warrant (the "Warrant"). In our examinations, we have assumed the genuineness of
all signatures,  the authenticity of all documents submitted to us as originals,
the  conformity to the originals of all documents  submitted to us as certified,
photostatic or conformed  copies,  and the  authenticity of the originals of all
such latter documents.

         Based upon such examination,  we are of the opinion that (a) the Shares
issuable to Sutro, when issued and delivered in accordance with the terms of the
Warrant,  will be  validly  issued,  fully paid and  non-assessable  and (b) the
Shares issued to the purchasers  under the Agreement were validly issued,  fully
paid and non-assessable .

         We hereby  consent  to the  filing of our  opinion as an exhibit to the
Registration Statement and to the reference to our firm under the caption "Legal
Matters" in the prospectus included in the Registration Statement.


                                                      Sincerely yours,


                                                      /s/ Lowenstein Sandler PC




<PAGE>


                                  EXHIBIT 23.1

                       CONSENT OF INDEPENDENT ACCOUNTANTS

The Board of Directors
Immunomedics, Inc.

We consent to the use of our report  incorporated herein by reference and to the
reference to our firm under the heading "Experts" in the Prospectus.


                                                                    /s/ KPMG LLP

Short Hills, New Jersey
January 7, 2000


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