MEDCO RESEARCH INC
8-A12B, 1998-11-24
PHARMACEUTICAL PREPARATIONS
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                                    FORM 8-A

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                     PURSUANT TO SECTION 12(b) OR (g) OF THE
                         SECURITIES EXCHANGE ACT OF 1934



                              MEDCO RESEARCH, INC.
                              --------------------
             (Exact name of registrant as specified in its charter)


                   Delaware                                   95-3318451     
- --------------------------------------------------------------------------------
   (State of incorporation or organization)               (I.R.S. Employer
                                                          Identification No.)


   7001 Weston Parkway, Cary, North Carolina             27513  
- ---------------------------------------------------------------------
   (Address of principal executive offices)           (Zip Code)



Securities to be registered pursuant to Section 12(b) of the Act:

                                                Name of each exchange
          Title of each class                   on which each class is
          to be so registered                   to be registered       
          -------------------                   ----------------       

Common Stock Purchase Rights with               New York Stock Exchange
respect to Common Stock, par value
$.001


Securities to be registered pursuant to Section 12(g) of the Act:


                                      None
                                ----------------
                                (Title of Class)

<PAGE>

Item 1.  Description of Registrant's Securities to be Registered

         Common Stock Purchase Rights with respect to Common Stock, $.001 Par 
         Value                                  

                  On April 2, 1998,  the Board of Directors  of Medco  Research,
Inc. (the "Company" or the "Registrant") declared a dividend distribution of one
Common Stock  Purchase  Right (a "Right") for each  outstanding  share of Common
Stock,  par value $.001, of the Company (the "Common  Stock").  The distribution
was made as of April  15,  1998 to  stockholders  of  record  as of the close of
business  on April  14,  1998 (the  "Record  Date").  Each  Right  entitled  the
registered  holder to purchase from the Company  one-half of one share of Common
Stock at a price of $92.00 per whole share, subject to adjustment (the "Purchase
Price").  The  description  and  terms of the  Rights  are set forth in a Rights
Agreement  dated as of April  14,  1998 (the  "Rights  Agreement")  between  the
Company  and  American  Stock  Transfer & Trust  Company,  as Rights  Agent (the
"Rights Agent").

                  Until the close of business on the  Distribution  Date,  which
will occur on the earlier of (i) the tenth  Business  Day (or such later date as
the Company's  Board of Directors  shall  determine)  after a person or group of
affiliated  or  associated  persons (an  "Acquiring  Person") has  acquired,  or
obtained  the  right  to  acquire,  beneficial  ownership  of 20% or more of the
Company's  outstanding Common Stock (the "Stock Acquisition  Date"), or (ii) the
tenth  Business  Day  (or  such  later  date as the  Board  of  Directors  shall
determine)  after the  commencement  of a tender  offer or exchange  offer which
would result in the offeror's ownership of 20% or more of the outstanding Common
Stock,  the Rights will be represented by and  transferred  with, and only with,
the Common Stock.  Until the  Distribution  Date,  new  certificates  issued for
Common  Stock  after the Record  Date will  contain a legend  incorporating  the
Rights  Agreement by  reference,  and the  surrender  for transfer of any of the
Common  Stock  certificates  will also  constitute  the  transfer  of the Rights
associated with the Common Stock  represented by such  certificates.  As soon as
practicable  following the Distribution Date,  separate Rights Certificates will
be mailed to holders of record of the Common  Stock as of the close of  business
on the Distribution Date, and thereafter  separate Right Certificates alone will
evidence the Rights.

                                       2
<PAGE>

                  The Rights are not  exercisable  until an event  occurs  which
gives  rise to a  Distribution  Date.  The  Rights  will  expire at the close of
business on April 15, 2008, unless earlier redeemed or terminated by the Company
as  described  below.  All  Common  Stock  certificates   issued  prior  to  the
Distribution Date will be issued with Rights.

                  The Purchase Price payable, and the number of Common Shares or
other securities or property  issuable,  upon exercise of the Rights are subject
to adjustment from time to time to prevent  dilution (i) in the event of a stock
dividend on, or a  subdivision,  combination or  reclassification  of the Common
Stock,  (ii) upon the grant to holders of the Common Stock of certain  rights or
warrants to subscribe  for Common Stock or  convertible  securities at less than
the current  market price of the Common Stock at the time of grant or (iii) upon
the  distribution  to holders of the Common Stock of evidences of  indebtedness,
cash (excluding  periodic regular cash dividends payable at a rate not in excess
of 125% of the rate of the last cash dividend  theretofore paid),  assets, stock
(other than  dividends  payable in Common  Stock) or of  subscription  rights or
warrants (other than those referred to above).

                  In the  event  that,  after the Stock  Acquisition  Date,  the
Company were to be acquired in a merger or other  business  combination  or more
than 50% of the  assets or earning  power of the  Company  and its  subsidiaries
taken  as a  whole  were  to be sold or  transferred  in one or more  series  of
transactions,  then each holder of record of a Right (other than Rights that are
or were beneficially owned by the Acquiring Person after the date upon which the
Acquiring  Person became such,  which Rights will thereafter be void) will, from
and after such date,  have the right to receive,  upon  payment of the  Purchase
Price, that number of shares of the common stock of the surviving,  resulting or
acquiring company having a market value at the time of such transaction equal to
two times the Purchase Price.

                  In the  event  that  any  person  or group  of  affiliated  or
associated  persons  becomes  the  beneficial  owner  of 20% or more of the then
outstanding  Common Stock, or after the Stock Acquisition Date any person merges
with or into the  Company  and any  shares  of the  Company's  Common  Stock are
changed into or exchanged for other securities or assets,  then each holder of a

                                       3
<PAGE>

Right (other than Rights  beneficially  owned by the Acquiring  Person after the
date upon which the Acquiring  Person became such,  which Rights will thereafter
be void) will thereafter have the right to receive, upon payment of the Purchase
Price,  that number of shares of Common Stock having a market value equal to two
times the Purchase Price.

                  At any time after the later of the  Distribution  Date and the
first occurrence of a triggering event, the Company may, at its option, exchange
all or part of the then  outstanding and  exercisable  Rights (other than Rights
owned by an Acquiring Person) for Common Stock at an exchange ratio of one share
of Common Stock per Right.

                                       4
<PAGE>

                  To the extent  that  insufficient  shares of Common  Stock are
available  for the  exercise  in full of the  Rights,  holders  of  Rights  will
receive, upon exercise,  shares of Common Stock to the extent available and then
cash, property or other securities of the Company (which may be accompanied by a
reduction in the Purchase  Price),  in proportions  determined by the Company so
that the aggregate value received is equal to twice the Purchase Price.

                  No  fractional  shares of Common Stock  (other than  fractions
which may, at the election of the Company, be evidenced by depositary  receipts)
will be issued upon the  exercise of Rights.  In lieu of  fractional  shares the
Company  may pay to the  holders  of Rights a payment  in cash equal to the same
fraction of the closing price of the Common Stock on the trading day immediately
prior to the date of exercise.

                  The Company  may redeem the Rights in whole,  but not in part,
at a price of $.01 per Right (the  "Redemption  Price") at any time prior to the
later of (i) the Distribution Date and (ii) the Stock Acquisition Date, provided
that the right of redemption  shall cease upon the  occurrence of any triggering
event.  Immediately  upon  the  action  of the  Board of  Directors  authorizing
redemption of the Rights,  the right to exercise the Rights will terminate,  and
the holders of Rights will only be  entitled  to receive  the  Redemption  Price
without any interest thereon.

                  Except for an  amendment  which  would  change the  Redemption
Price,  the  Purchase  Price or the number of shares of Common Stock for which a
Right is exercisable,  (a) prior to the Distribution  Date the Company may amend
the Rights Agreement in any manner and (b) from and after the Distribution  Date
the Company may amend the Right  Agreement in any manner that does not adversely
affect the  interest of the holders of Rights  other than an  Acquiring  Person;
provided,  however, that between April 15, 2001 and September 30, 2001 the Board
of  Directors  shall  review  the  other  provisions  of the  Rights  Agreement,
including  without  limitation  the Final  Expiration  Date,  to determine  what
amendments,  if any,  are  necessary or  appropriate  to better  effectuate  its
purposes.

                  Until a Right is exercised,  the holder thereof, as such, will
have no rights as a stockholder of the Company,  including,  without limitation,
the right to vote or to receive dividends.

                                       5
<PAGE>

                  The foregoing description of the Rights does not purport to be
complete and is qualified in its entirety by reference to the Rights  Agreement,
which is an exhibit to this  Registration  Statement and is incorporated in this
summary description by reference.


Item 2.  Exhibits.

                                    Description
                                    -----------

                        1.          Rights  Agreement,  dated  as of  April  14,
                                    1998,  between  Medco  Research,   Inc.  and
                                    American Stock Transfer & Trust Company,  as
                                    Rights Agent,  as filed as an Exhibit to the
                                    Form 8-A  filed by  Registrant  on April 15,
                                    1998,  as amended in the Form  8-A/Amendment
                                    No.   1  filed  on  April   27,   1998,   is
                                    incorporated herein by reference.

                        2.          All exhibits  required by  Instruction II to
                                    Item 2 will  be  supplied  to the  New  York
                                    Stock Exchange.



                                   SIGNATURES

Pursuant to the requirements  of Section 12 of the  Securities  Exchange  Act of
1934, the Registrant has duly caused this registration statement to be signed on
its behalf by the undersigned, thereto duly authorized.

                                            MEDCO RESEARCH, INC.



Date:  November 23, 1998                    /s/ Glenn Andrews             
                                            ------------------------------
                                            Name:  Glenn Andrews
                                            Title: Chief Financial Officer
                                                   Vice President-Finance
                                                   & Administration

                                       6


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