MANULIFE SERIES FUND INC
497, 1995-12-28
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                                                   497(e)
                                                   File No. 2-85454


MANULIFE SERIES FUND, INC.


Supplement to Statement of Additional Information
for Prospectus for Manulife Series Fund, Inc.
Dated May 1, 1995




This supplement updates certain information in the Prospectus. 
Please read it and keep it with your Prospectus for future
reference.

     On December 27, 1995, the Manager, Manufacturers Adviser
     Corporation, became a wholly-owned subsidiary of The
     Manufacturers Life Insurance Company of America.  Both the
     Manager and The Manufacturers Life Insurance Company of
     America are indirect wholly-owned subsidiaries of The
     Manufacturers Life Insurance Company.


The date of this Supplement is December 27, 1995.







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