MANULIFE SERIES FUND INC
24F-2NT, 1997-02-26
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U.S. SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 24F-2
Annual Notice of Securities Sold
Pursuant to Rule 24f-2

Read instructions at end of Form before preparing Form.
Please print or type.

  1.  Name and address of issuer:
      Manulife Series Fund, Inc.
      200 Bloor Street East, Toronto, Ontario M4W 1E5

  2.  Name of each series or class of funds for which
      this notice is filed:
      Shares of Common Stock

  3.  Investment Company Act File Number: 811-3815  

      Securities Act File Number: 2-85454

  4.  Last day of fiscal year for which this notice is
      filed:
               December 31, 1996

  5.  Check box if this notice is being filed more than
      180 days after the close of the issuer's fiscal   
      year for purposes of reporting securities sold    
      after the close of the fiscal year but before     
      termination of the issuer's 24f-2    
      declaration:
                                                        
               N/A     

  6.  Date of termination of issuer's declaration under
      rule 24f-2(a)(1), if applicable (see instruction  
      A.6):
                                                        
               N/A

  7.  Number and amount of securities of the same class
      or series which had been registered under the     
      Securities Act of 1933 other than pursuant to rule 
      24f-2 in a prior fiscal year, but which remained  
      unsold at the beginning of the fiscal year:
                                                        
               174,727 Shares

  8.  Number and amount of securities registered during
      the fiscal year other than pursuant to rule 24f-2:
                                                        
               None

  9.  Number and aggregate sale price of securities
      sold during the fiscal year:
                                                        
               None*

      *Excluded from this item, in reliance on
       instruction B.5., are 14,031,475 Shares with an  
       aggregate sale price of $202,015,197, sold to    
       unmanaged separate accounts that offered interests

       on which a registration fee has been paid.

 10.  Number and aggregate sale price of securities
      sold during the fiscal year in reliance upon      
      registration pursuant to rule 24f-2:
                                                        
               None*

      *Excluded from this item, in reliance on
       instruction B.5., are 14,031,475 Shares with an  
       aggregate sale price of $202,015,197, sold to    
       unmanaged separate accounts that offered interests

       on which a registration fee has been paid.       
     

 11.  Number and aggregate sale price of securities
      issued during the fiscal year in connection with  
      dividend reinvestment plans, if applicable (see   
      instructions B.7):
                                     
               N/A

 12.  Calculation of registration fee:

   (i)   Aggregate sale price of securities sold during
         the fiscal year in reliance on rule 24f-2
         (from Item 10):                                

               0

  (ii)   Aggregate price of shares issued in connection
         with dividend reinvestment plans (from
         Item 11, if applicable):

               + 

 (iii)   Aggregate price of shares redeemed or
         repurchased during the fiscal year 
         (if applicable)

               - 
 
<PAGE>
  (iv)   Aggregate price of shares redeemed or repur-
         chased and previously applied as a reduction
         to filing fees pursuant to rule 24e-2 
         (if applicable):                               
       

   (v)   Net aggregate price of securities sold and
         issued during the fiscal year in reliance
         on rule 24f-2 [line (i), plus line (ii),
         less line (iii), plus line (iv)](if 
         applicable)                                    

               0

  (vi)   Multiplier prescribed by Section 6(b) of the
         the Securities Act of 1933 or other applicable
         law or regulation (see Instruction C.6):      

               X  1/3300

 (vii)   Fee due [line (i) or line (v) multiplied
         By line (vi)]
                               
               None   
                                                    
Instruction: Issuers should complete lines (ii), (iii),
(iv), and (v) only if the form is being filed within 60
days after the close of the issuers' fiscal year.  See
Instruction C.3.




  13.  Check box if fees are being remitted to the
       Commission's lockbox depository as described in  
       section 3a of the Commission's Rules Of Informal 
       and other Procedures (17 CFR 202.3a).
                                                        
               [ ]

       Date of mailing or wire transfer of filing fees
       to the Commission's lockbox depository:

                                  
<PAGE>
SIGNATURES

This report has been signed below by the following
persons on behalf of the issuer and in the capacities
and on the dates indicated.

By (Signature and Title)*

/s/   Douglas Myers  
Douglas Myers, Vice President


Date:   February 25, 1997


* Please print the name and title of the signing
officer below the signature.

<PAGE>






February 25, 1997

Board of Directors
The Manufacturers Life Insurance Company
  of America
200 Bloor Street, East
Toronto, Ontario M4W 1E5


Gentlemen:

You have requested my opinion for use in conjunction
with a Rule 24f-2 Notice for Manulife Series Fund, Inc.
("Fund") to be filed in respect of shares of the Fund
(the "Shares") sold for the fiscal year ended
December 31, 1996, pursuant to the registration
statement filed with the Securities and Exchange
Commission ("SEC") under the Securities Act of 1933
(File No. 2-85454)("Registration Statement").

In its Registration Statement, as amended, the Fund
elected to register an indefinite number of Shares
pursuant to the provisions of SEC Rule 24f-2.

I have reviewed the amended Registration Statement of
the Fund and such other documents, records and
certification of facts by a company officer as I have
deemed necessary.  On the basis of the foregoing, it is
my opinion that the Shares sold for the fiscal year
ended December 31, 1996, registration of which the Rule
24f-2 Notice makes definite in number, were legally
issued, fully paid and non-assessable.

I consent to your filing this opinion as an Exhibit to
the Rule 24f-2 Notice referred to above, to the
Registration Statement of the Fund and to any
applicable statement filed under the Securities Laws of
the United States.

Very truly yours,

/s/ James D. Gallagher

James D. Gallagher




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