BURZYNSKI RESEARCH INSTITUTE INC
10SB12G/A, 1998-04-28
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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       As Filed with the Securities and Exchange Commission on April 28, 1998
                                                            File No. 000-23425


               UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                AMENDMENT NO. 3
                                      TO
                                  FORM 10-SB

             GENERAL FORM FOR REGISTRATION OF SECURITIES OF SMALL
                               BUSINESS ISSUERS

          UNDER SECTION 12(b) OR 12(g) OF THE SECURITIES ACT OF 1934



     BURZYNSKI  RESEARCH  INSTITUTE,  INC.
     -------------------------------------
     (Name  of  small  business  issuer  in  its  Charter)


                            Delaware                                76-0136810
- ------------------------------------                          ----------------
(State  or  Other  Jurisdiction  of  Incorporation  or  Organization)
(I.R.S.  Employer
                                           Identification  No.)


    12000  Richmond  Avenue,  Houston,  Texas
- ---------------------------------------------
77082-2431
- ----------
        (Address  of  Principal  Executive  Offices)
(Zip  Code)



                                     (281) 597-0111
                             ----------------------
                           (Issuer's Telephone No.)


Securities  to  be  registered  under  Section  12(b)  of  the  Act:


 Title  of  each class                          Name of Each Exchange on which
     to  be  so  Registered                                Each Class is to be
     ----------------------                           ------------------------
Registered
    ------

                       None                                                N/A
- ---------------------------                      -----------------------------




Securities  to  be  Registered  under  Section  12(g)  of  the  Act:


                         Common  Stock,  $.001  par  value
     -----------------------------------------------------
                   (Title  of  Class)


                                        (Title  of  Class)

                                       1

                                      F-2





     --ooOoo--

     C  0  N  T  E  N  T  S
     ----------------------


     Page
     ----

Report  of  Independent  Auditors          2

Combined  Balance  Sheet          3

Combined  Statements  of  Operations          4

Combined  Statements  of  Stockholders'  Deficit          5

Combined  Statements  of  Cash  Flows          6

Notes  to  Combined  Financial  Statements          7-14


<PAGE>
                        REPORT OF INDEPENDENT AUDITORS




To  the  Board  of  Directors  and  Stockholders
of  Burzynski  Research  Institute,  Inc.



We have audited the accompanying combined balance sheets of Burzynski Research
Institute, Inc. and S.R. Burzynski, M.D., Ph.D., Clinical Trials (the Company)
as  of  February  28,  1997  and  February  29, 1996, and the related combined
statements  of operations, stockholders' deficit, and cash flows for the years
then  ended.    These  financial  statements  are  the  responsibility  of the
Company's  management.    Our responsibility is to express an opinion on these
financial  statements  based  on  our  audits.

We  conducted  our  audits  in  accordance  with  generally  accepted auditing
standards.    Those  standards  require that we plan and perform the audits to
obtain reasonable assurance about whether the financial statements are free of
material misstatement.  An audit includes examining, on a test basis, evidence
supporting  the amounts and disclosures in the financial statements.  An audit
includes  assessing  the  accounting principles used and significant estimates
made  by  management,  as  well  as evaluating the overall financial statement
presentation.    We believe that our audits provide a reasonable basis for our
opinion.

In  our opinion, the financial statements referred to above present fairly, in
all  material  respects, the combined financial position of Burzynski Research
Institute,  Inc.  and  S.R.  Burzynski,  M.D.,  Ph.D.,  Clinical  Trials as of
February  28,  1997  and  February  29, 1996 and the results of their combined
operations  and  their  combined  cash  flows  for  the  years  then ended, in
conformity  with  generally  accepted  accounting  principles.

The  accompanying  financial  statements  have been prepared assuming that the
Company  will  continue  as  a  going  concern.  As discussed in Note 2 to the
financial  statements,  the Company has incurred losses from operations, has a
working  capital  deficit  and  has  a  net  capital  deficiency  that  raises
substantial  doubt  about  its  ability  to  continue  as  a  going  concern.
Management's  plans regarding those matters are also described in Note 2.  The
financial statements do not include any adjustments that might result from the
outcome  of  this  uncertainty.    



/s/  Seitz  &  DeMarco,  P.C.
- ------------------------------
Seitz  &  DeMarco,  P.C.
Certified  Public  Accountants



Houston,  Texas
April  14,  1998



<PAGE>

BURZYNSKI  RESEARCH  INSTITUTE,  INC.
COMBINED  BALANCE  SHEETS
FEBRUARY  28,  1997  AND  FEBRUARY  29,  1996



                                   1997               1996
                                   ----               ----
ASSETS

Current  assets

  Cash  and  cash  equivalents  (Note  1)               $             15,716
                                                        -     --------------
                                                       $               5,945
                                                       -     ---------------

                           Total current assets                       15,716
                                                                       5,945

Property  and  equipment,  net  of  accumulated  depreciation
              and amortization (Notes 1,3 and 7)                     653,799
                                                                     699,818

     Other assets                         9,032                       29,564
                                ---------------               --------------

                        Total assets          $           678,547          $
                                              =     =============          =
                                                                     735,327
                                                                          ==


LIABILITIES  AND  STOCKHOLDERS'  EQUITY

Current  liabilities

              Notes payable (Note 4)          $           164,000          $
                                                                     164,000
               Current maturities of long-term debt (Note 5 and 10)
                                         2,796                         3,282
               Current portion of capital lease obligations (Note 7)
                                         65,066                       92,238
                      Accounts payable (Note 11)                     793,428
                                                                     443,831
                             Accrued liabilities                     468,716
                                                               -------------
                                                                     422,291
                                                                           -

                       Total current liabilities                   1,494,006
                                                                   1,125,642

               Long-term debt, less current maturities (Notes 5 and 10)
                                         10,280                       13,076
               Capital lease obligation, less current portion (Note 7)
                                         137,495                     184,044
Commitments  and  contingencies  (Notes 12 and 14)                         -
                                                               -------------
                      -
          -------------

                               Total liabilities                   1,641,781
                                                                   1,322,762

Stockholders'  deficit

    Common  stock,  $.001  par  value;  200,000,000  shares
        authorized, 131,289,444 shares issued and outstanding
                                         131,289                    131,289
    Additional paid-in capital                                    24,851,023
                                                                  17,273,782
      Retained deficit                (25,945,546)              (17,992,506)
                                     -------------             -------------

                        Total stockholders' deficit                (963,234)
                                                                    (587,435)


                      Total liabilities and stockholders' deficit          $
                                                                            =
                                         678,547          $           735,327
                                            ====          =     =============


The  accompanying  notes  are  an  integral  part  of these combined financial
statements


<PAGE>

BURZYNSKI  RESEARCH  INSTITUTE,  INC.
COMBINED  STATEMENTS  OF  OPERATIONS
FOR  THE  YEARS  ENDED  FEBRUARY  28,  1997  AND  FEBRUARY  29,  1996



                                   1997               1996
                                   ----               ----


Revenue
                     Other income          $                  170          $
                                            -     ----------------          -
                                                            15,223
                                                                            -

                    Total revenue                            170
                                                            15,223

Operating  expenses
          Research and development (Notes 1and 11)                   6,735,605
                                                                     5,713,241
                        General and administrative                     983,154
                                                                     1,206,326
                             Depreciation (Note 3)                     234,451
                                                                 -------------
                                                                       262,179
                                                                           ---

                          Total operating expenses                   7,953,210
                                                                 -------------
                                                                     7,181,746
                                                                     ---------

                Net loss before provision for tax                  (7,953,040)
                                                                   (7,166,523)

                Provision for tax (Notes 1 and 8)                            -
                                                                --------------
                                                                        19,650
                                                                        ------

          Net loss          $        (7,953,040)          $        (7,186,173)
                            =     ==============          =     ==============





Earnings  per  share  information:

                  Net loss per share          $            (0.0606)          $
                                              =     ===============          =
                                                                      (0.0547)
                                                                            ==

















The  accompanying  notes  are  an  integral  part  of these combined financial
statements

<PAGE>

BURZYNSKI  RESEARCH  INSTITUTE,  INC.
COMBINED  STATEMENTS  OF  STOCKHOLDERS'  DEFICIT
FOR  THE  YEARS  ENDED  FEBRUARY  28,  1997  AND  FEBRUARY  29,  1996




                                                 Additional
                             Common          Paid-in               Retained
                              Stock          Capital               Deficit
                                -----          -------               -------


Balance February 28, 1995          $           131,289          $
                            10,518,018          $      (10,806,333)

    FDA  clinical  trial  expenses  paid  directly  by
        S.R. Burzynski M.D., Ph. D.                               6,755,764

           Net loss                                             (7,186,173)
                                                             --------------

                      Balance February 29, 1996                     131,289
                                     17,273,782                (17,992,506)

    FDA  clinical  trial  expenses  paid  directly  by
        S.R. Burzynski M.D., Ph. D.                               7,577,241

             Net loss                                           (7,953,040)
                                                               ------------

            Balance February 28, 1997      $           131,289          $
                                            =     =============          =
                                     24,851,023          $      (25,945,546)
                                             ====          =     =============



















The  accompanying  notes  are  an  integral  part  of these combined financial
statements

<PAGE>

BURZYNSKI  RESEARCH  INSTITUTE,  INC.
COMBINED  STATEMENTS  OF  CASH  FLOWS
FOR  THE  YEARS  ENDED  FEBRUARY  28,  1997  AND  FEBRUARY  29,  1996

CASH  FLOWS  FROM  OPERATING  ACTIVITIES
          Net loss          $        (7,953,040)          $        (7,186,173)
    Adjustments  to  reconcile  net  income  to
    net  cash  provided  by  operating  activities:
          Depreciation                     234,451                     262,179
    (Increase)  decrease  in
                           Other current assets                              -
                                                                       181,935
                                     Other assets                       20,532
                                                                      (4,514)
    Increase  (decrease)  in
                                   Accounts payable                     349,597
                                                                       322,450
                               Accrued liabilities                       46,425
                                                                --------------
                                                                   (133,376)
                                                                       -------

           NET CASH USED  BY OPERATING ACTIVITIES                  (7,302,035)
                                                                   (6,557,499)

CASH  FLOWS  FROM    INVESTING  ACTIVITIES
              Purchases of property and equipment                    (166,755)
                                                                --------------
                                                                     (127,496)
                                                                --------------

            NET CASH USED BY INVESTING ACTIVITIES                    (166,755)
                                                                     (127,496)

CASH  FLOWS  FROM  FINANCING  ACTIVITIES
                      Proceeds from long-term debt                           -
                                                                        17,500
                     Payments on long-term debt                        (3,282)
                                                                       (1,142)
                       Payments on short-term debt                           -
                                                                      (10,000)
           Payments on capital lease obligations                      (95,398)
                                                                      (79,842)
                        Additional paid-in capital                   7,577,241
                                                                 -------------
                                                                     6,755,764
                                                                      --------

             NET CASH USED BY FINANCING ACTIVITIES                   7,478,561
                                                                 -------------
                                                                     6,682,280
                                                                 -------------

                 NET INCREASE (DECREASE) IN CASH                         9,771
                                                                       (2,715)

                       CASH AT BEGINNING OF YEAR                         5,945
                                                               ---------------
                                                                         8,660
                                                                         -----

                  CASH AT END OF YEAR          $             15,716          $
                                               =     ==============          =
                                                                         5,945
                                                                          ====


SUPPLEMENTAL  CASH  FLOW  DISCLOSURES:
    Cash  Paid  During  the  Year  For:
      Income  taxes                    $                   32,000          $

         Interest          $             36,097          $             41,926

SCHEDULE  OF  NON-CASH  FINANCING  ACTIVITIES:
                  Equipment acquired under capital lease obligation          $
                                           21,677          $           194,674


The  accompanying  notes  are  an  integral  part  of these combined financial
statements

<PAGE>
BURZYNSKI  RESEARCH  INSTITUTE,  INC.
NOTES  TO  COMBINED  FINANCIAL  STATEMENTS
FEBRUARY  28,  1997  AND  FEBRUARY  29,  1996


1.          Summary  of  Significant  Accounting  Policies:

Basis  of  Combination

The  combined  financial statements of Burzynski Research Institute, Inc. (the
Company)  include  the  accounts  of  Burzynski  Research  Institute,  Inc., a
Delaware corporation; and those of S.R. Burzynski, M.D., Ph.D. (Dr. Burzynski)
related  to  the  conduct  of  FDA approved clinical trials for antineoplaston
drugs used in the treatment of cancer and other diseases.  Accounts related to
Dr.  Burzynski's  medical  practice  have not been included in these financial
statements.    Dr. Burzynski is the President, Chairman of the Board and owner
of  over  80%  of the outstanding stock of Burzynski Research Institute, Inc.,
and  also  is the inventor and original patent holder of certain drug products
known  as  "antineoplastons".  All  significant  intercompany transactions and
balances  have  been  eliminated.

Business  Activity

The  Company holds the exclusive right in the United States, Canada and Mexico
to  use,  manufacture,  develop,  sell,  distribute,  sublicense and otherwise
exploit  all  the  rights, titles and interest in antineoplaston drugs used in
the  treatment  of  cancer,  once  the drug is approved for sale by the United
States  Federal  Drug  Administration.  The  Company is primarily engaged as a
research  and development facility of drugs currently being tested for the use
in  the  treatment  of  cancer,  and  provides  consulting  services.

Property  and  Equipment

Property  and  equipment  are  recorded  at  cost  and  depreciated  using the
straight-line method over the estimated useful lives of the assets which range
from  5  to  31.5 years.  Expenditures for major renewals and betterments that
extend the useful lives of property and equipment are capitalized; maintenance
and  repairs  are  charged  against  earnings  as  incurred.  Upon disposal of
assets,  the  related  cost  and accumulated depreciation are removed from the
accounts  and  any  resulting  gain  or  loss  is  recognized  currently.

Research  and  Development

Research  and development cost are charged to operations in the year incurred.
Equipment  used in research and development activities, which have alternative
uses,  are  capitalized.

Cash  and  Cash  Equivalents

The Company considers all highly liquid investments purchased with an original
maturity  of  three  months  or  less  to  be  cash  equivalents.

Income  Taxes

The  Company  uses  the liability method of accounting for income taxes, under
which  deferred  income  taxes  are  recognized  for  the  tax consequences of
temporary differences by applying the enacted statutory tax rate applicable to
future  years  to differences between financial statement carrying amounts and
the  tax  basis  of existing assets and liabilities.  Valuation allowances are
established  when  necessary  to  reduce  deferred  tax  assets  to the amount
expected  to be realized.  Income tax expense is the tax payable or refundable
for  the  period  plus  or  minus the change during the period in deferred tax
assets  and liabilities.  The accounts of S.R. Burzynski, M.D., Ph.D., related
to  the  conduct  of  FDA  approved  clinical trials are taxed directly to Dr.
Burzynski  and  are  not  included  in  the  Company's  tax  provision.

Management  Estimates

The  preparation of financial statements in conformity with generally accepted
accounting    principles requires management to make estimates and assumptions
that  affect  reported  amounts  of assets and liabilities at the dates of the
financial  statements and the reported amounts of revenues and expenses during
the  reported  periods.    Actual  results  could differ from those estimates.

2.          Basis  of  Presentation:

The  Company  has  prepared its financial statements on the basis that it will
continue  as  a  going  concern.    As of February 28, 1997, the Company had a
working capital deficit of approximately $1,480,000, an accumulated deficit of
approximately  $25,945,000. For the years ended February 28, 1997 and February
29,  1996,  the  Company  incurred  losses  of  approximately  $7,953,000  and
$7,186,000, respectively.  Effective March 1, 1997 the Company entered into an
agreement  with  Stanislaw  R.  Burzynski  M.D.,  Ph.D. in which Dr. Burzynski
agreed  to  fund  the  basic  research  costs,  FDA  related costs and provide
research  and  lab  space  for  one  year.    Also, it is the intention of the
directors  and  management  to  seek  additional  capital  through the sale of
securities.    The proceeds from such sales will be used to fund the Company's
operating  deficit  until it achieves positive operating cash flow.  There can
be  no  assurance  that  the  Company  will  be  able to raise such additional
capital,  or  that  Dr.  Burzynski  will be able to continue to fund the basic
research  and  FDA  related  cost.

3.          Property  and  Equipment:

Property  and  equipment  consisted  of  the  following:

                           Estimated
                              Useful  Lives                               1997
                                                                          ----
1996
   -

Production equipment                  5  -  10   years     $   3,259,622     $
3,259,622
Leasehold  improvements                     5  - 31.5 years          1,568,442
1,528,780
Furniture  and  equipment                 5  -  10   years             603,367
321,691
Equipment  under  capital  lease         4  -   5    years             288,943
                                                               ---------------
       422,019
- --------------

     Total  property  and  equipment                                 5,720,374
5,532,112

Accumulated  depreciation  and  amortization                       (5,066,575)
                                                               --------------
(4,832,294)
- ----------

                                        $            653,799     $     699,818
                                        ====================     =============

Depreciation  and  amortization  expense for the years ended February 28, 1997
and  February  29,  1996  was  $234,451  and  $262,179,  respectively.

4.          Notes  Payable:

Notes  payable  consisted  of  the  following:
             1997                        1996
             ----                        ----
Note  payable  to  an  individual  dated  April  27,
1992,  unsecured,  bearing  interest  of  6.75%  due
annually.    The  note  is  due  on demand.               $      100,000     $
100,000

Note  payable  to  an  individual  dated  August  11,
1992,  unsecured,  bearing  no  interest  due  on
demand,  with  monthly  principal  payments  of
$2,000  if  funds  are  available.                                      64,000
                                                              ----------------
64,000
- ------

                                        $            164,000     $     164,000
                                        ====================     =============

5.          Long-Term  Debt:

Long-term  debt  consisted  of  the  following:

                                                  1997                    1996
                                                  ----                    ----
Note  payable  to  a  bank  dated  November  25,
1994,  unsecured,  and  bearing  interest  at  the
banks  base  rate  plus  3.45%  (approximately
12%)  due  in  36  monthly  installments  beginning
November  25,  1995  of  3%  of  the  unpaid  balance
plus  interest  with  any  unpaid  balance  due
November  25,  1998.    The  note  is  guaranteed  by
the  Company's  majority  shareholder.                    $       13,076     $
16,358

Less  :    Current  maturities                                           2,796
                                                              ----------------
3,282
- -----


$              10,280          $              13,076
=====================          =====================

6.          Employee  Benefits:

The  Company  has  a  self  funded employee benefit plan providing health care
benefits  for  all  its  employees.  It  also  provides  for them group dental
insurance,  short-term and long-term disability insurance, and life insurance.
The  Company  pays 100% of the cost for its employees and 50% of any dependent
coverage.    The plan has a $200 deductible and a maximum life time benefit of
$1,000,000  per  covered  participant.    Due to stop-loss insurance, benefits
payable  by  the  Company  are limited to $12,500 per person during the policy
year.    The Company charged to operations a provision of $97,257 for 1997 and
$97,073  for  1996,  which  represents  the  sum  of actual claims paid and an
estimate  of  liabilities  relating  to  claims, both asserted and unasserted,
resulting  from  incidents  that  occurred  during  the  year.

7.          Leases  Commitments:

The  Company leases certain equipment under agreements which are classified as
capital  leases.    Cost  and  accumulated amortization of such assets totaled
$288,943  and  $422,019;   $144,571 and $185,613, respectively, as of February
28,  1997  and  February  29,  1996.    Future  minimum  lease  payments under
noncancelable  lease  agreements  are  as  follows:

               Fiscal  year  ending
               February  28  or  29:

                    1998                                           $    84,260
                    1999                                                76,775
                    2000                                                60,932
                    2001                                                16,348
                    2002                                                   386
                                                                --------------

Total  future  minimum  lease  payments                                238,701
Less  amount  representing  interest                                    36,140
                                                                  ------------
Present  value  of  future  minimum  lease  payments                   202,561
Less  current  portion of capital lease obligations                     65,066
                                                                  ------------

Long-term  capital  lease  obligations                              $  137,495
                                                                    ==========

The  Company  leases  laboratory  facilities, office space and equipment under
agreements  which  are  classified as operating leases.  Rent expense incurred
under these leases was approximately $297,680 and $316,324 for the years ended
February  28,  1997 and February 29, 1996, respectively.  All lease agreements
are  on  a  month  to  month  basis.

8.          Income  Taxes:

The  actual  income  tax  benefit attributable to the Company's losses for the
years  ended  February 28, 1997 and February 29, 1996, differ from the amounts
computed  by  applying  the  U.S. federal income tax rate of 34% to the pretax
loss  as  a  result  of  the  following:

1997                          1996
- ----                          ----

Expected  benefit                            $  (2,704,034)     $  (2,436,618)
Nondeductible  expenses                                                  1,509
319
Taxed  directly  to  Dr.  Burzynski                                  2,519,814
2,426,129
Change  in  valuation  allowance                                       182,711
10,170
State  franchise  tax                                                        -
                                                               ---------------
19,650
- ------

Income  tax  expense  (benefit)          $              -      $        19,650
                                         ================      ===============

The  components of the Company's deferred income tax assets as of February 28,
1997  and  February  29,  1996  were  as  follows:
                                              1997                        1996
                                              ----                        ----
Deferred  tax  assets:
     Net  operating  loss  carryforwards                  $      317,738     $
140,702
     Excess  book  depreciation                                         26,416
21,501
     Accrued  expenses                                                  90,615
89,855
     Alternative  minimum  tax  credit  carryforwards                   42,603
                                                              ----------------
42,603
- ------

          Total  deferred  tax  assets                                 477,372
294,661
          Less  valuation  allowance                                 (477,372)
                                                              ---------------
(294,661)
 -------

                    Net deferred tax assets     $          -     $           -
                                                ============     =============
_

The  Company's  ability  to  utilize  net  operating  loss  carryforwards  and
alternative  minimum  tax  credit  carryforwards will depend on its ability to
generate  adequate  future  taxable  income.    The  Company has no historical
earnings  on  which  to  base  an  expectation  of  future  taxable  income.
Accordingly,  a valuation allowance for the total deferred tax assets has been
provided.

The  Company  has  net operating loss carryforwards available to offset future
income  in the amounts of $925,699 as of February 28, 1997.  The net operating
loss  carryforwards  expire  as  follows:

          Year  ending
      February  28,  or  29,

          2007                                        $                 18,371
          2008                                                         383,639
          2011                                                          11,818
          2012                                                         511,871

The  Company  has  alternative minimum tax credit carryforwards of $42,603 and
investment  tax  credit  carryforwards  of $22,757.  The investment tax credit
carryforwards    expire  between  February  28,  1999  and  February 28, 2001.

9.          Economic  Dependency:

The  Company  received  the  majority of its funding from Stanislaw Burzynski,
M.D.,  Ph.DDr. Burzynski contributed capital to fund costs over and above the
income  received  by  the  Company.  The following is a summary of the capital
contributed  by  Stanislaw  Burzynski,  M.D.,  Ph.D.:
                                              1997                        1996
                                              ----                        ----

     Capital  contributed                                   $  7,577,241     $
                                                            ============     =
6,755,764
        =

10.          Fair  Value  of  Financial  Instruments:

Information  regarding  those financial instruments with fair values not equal
to  their  carrying value, none of which are held for trading purposes, are as
follows:

                           1997                                           1996
                          Carrying          Fair            Carrying      Fair
                          Amount          Value               Amount     Value
                          ------          -----               ------     -----

Noninterest  bearing  note payable     $   64,000    $   58,420     $   64,000
                                       ==========    ==========     ==========
$      58,420
=============

11.          Related  Party  Transactions:

Stanislaw  Burzynski,  M.D.,  Ph.D.,  is  President, Chairman of the Board and
owner  of  over 80% of the Company's outstanding stock.  Dr. Burzynski also is
the  inventor  and  original  patent  holder of certain drug products known as
"antineoplastons".   The Company has entered into a license agreement with Dr.
Burzynski  which  gives  the Company the exclusive right in the United States,
Canada  and  Mexico to use, manufacture, develop, sell, distribute, sublicense
and  otherwise  exploit  all  of  his  rights,  titles  and  interests  in
antineoplaston  drugs  used  in  the  treatment  of  cancer, including but not
limited  to  any  patent  rights which may be granted in these countries.  The
license  is  terminable  at  the  option of Dr. Burzynski, if he is removed as
Chairman  of  the  Board or President of the Company, or if any shareholder or
group  of  shareholders  acting in concert becomes the beneficial owner of the
Company's  securities  having voting power equal to or greater than the voting
power  of  the  securities held by him.  This license agreement was amended on
March  1,  1990 by granting to Dr. Burzynski the limited right to manufacture,
use,  and  exploit antineoplastons in the Company's exclusive territory solely
for  the  purpose  of  enabling Dr. Burzynski to treat patients in his medical
practice until the date on which the United States Federal Drug Administration
approves the sale of antineoplastons for the treatment of cancer in the United
States.

Effective January 23, 1992, the Company restructured its relationship with Dr.
Burzynski.    As  a  result  of  the  restructuring,  all  manufacturing  was
transferred  to  Dr.  Burzynski's  medical  practice  and  the  Company  began
operating solely as a research and development facility of antineoplastons for
the  use  in  the  treatment  of cancer and also provides consulting services.

12.          Litigation  Matters:

The  Company  is  involved  in  lawsuits  arising  in  the  ordinary course of
business.    In the opinion of the Company's legal counsel and management, any
liability  resulting from such litigation would not be material in relation to
the  Company's  financial  position.

13.          Subsequent  Events:

Effective  March  1,  1997 the Company ("BRI") entered into a research funding
agreement  with  Stanislaw  R.  Burzynski, M.D.Ph.D.("SRB") and terminated the
royalty  agreement  entered  into  on January 23, 1992 more fully described in
note  11.   The research funding agreement states that SRB is the inventor and
original patent holder of certain drug products known as "antineoplastons" and
BRI  owns  the rights to exploit "antineoplastons" for the treatment of cancer
in the United States, Canada and Mexico.  It also states that none of the drug
formulations  are currently approved for interstate marketing by the U.S. Food
and  Drug  Administration,  ("FDA")  but  SRB  is  currently  the  principal
investigator  of approximately 74 FDA approved clinical trials, the purpose of
the  clinical  trials  is  to  obtain  said  FDA  approval; and it is mutually
advantageous  that  basic  science  research  continue  to develop, refine and
improve  antineoplastons.   BRI is willing to undertake such research but does
not  currently  have  sufficient  funds  to  conduct  the research, and SRB is
willing  to  fund  such  research  until  a  permanent  source of financing is
obtained.

The  parties  agreed  to  the  following:

1.      BRI agrees to undertake all scientific research in connection with the
development  of  new  or improved antineoplastons for the treatment of cancer.
BRI  will  hire such personnel as is required to fulfill its obligations under
the  agreement.

     2.        SRB agrees to fund in its entirety all basic research which BRI
undertakes  in  connection  with  the  development of other antineoplastons or
refinements  to  existing  antineoplastons  for  the  treatment  of  cancer.

     3.      As FDA approval of antineoplastons will benefit both parties, SRB
agrees  to  pay  the  expenses  to  conduct  the  clinical  trials  for  BRI.

4.         SRB agrees to provide BRI such laboratory and research space as BRI
needs  at the Trinity Drive facility in Stafford, Texas, and such office space
as  is  necessary  at  Trinity  Drive  and  at 12000 Richmond Avenue facility.

5.         In the event the research described in the agreement results in the
approval  of any additional patents, SRB shall own all such patents, but shall
license to BRI the patents based on the same terms, conditions and limitations
as  is  in  the  current  license  between  the  parties.

6.         SRB shall have unlimited and free access to all equipment which BRI
owns, so long as such use is not in conflict with BRI's use of such equipment,
including  without  limitation  to  all  equipment  used  in  manufacturing of
antineoplastons  used  in  the  clinical  trials.

7.      The amounts which SRB is obligated to pay under the agreement shall be
reduced  dollar  for  dollar  by  the  following:

a.      Any income which BRI receives for services provided to other companies
for  research  and/or  development  of  other products, less such identifiable
marginal  or  additional  expenses  necessary  to produce such income (such as
purchase  of  chemicals,  products  or equipment solely necessary to engage in
such  other  research  and  development  activity).

          b.       The net proceeds of any stock offering or private placement
which  BRI  receives  during  the  term  of  the  agreement up to a maximum of
$1,000,000  in  a  given  BRI  fiscal  year.

8.       The initial term of the agreement is one year.  The agreement will be
automatically  renewable for three additional one year terms, unless one party
notifies  the  other party at least ninety days prior to the expiration of the
term  of  the  agreement  of  its  intention  not  to  renew  the  agreement.

9.      The agreement shall automatically terminate in the event that SRB owns
less  than  fifty  percent  of the outstanding shares of BRI, or is removed as
President  and  or  Chairman  of  the Board of BRI, unless SRB notifies BRI in
writing his intention to continue the agreement notwithstanding this automatic
termination  provision.

On  February  10,  1998  Burzynski  Research  Institute, Inc. and Stanislaw R.
Burzynski  settled their lawsuit with the Department of Health of the State of
Texas  (DOH)  which  had  been  file  in  January  1992.   The Company and Dr.
Burzynski  agreed  to pay reasonable attorneys fees and investigative expenses
in  the  amount  of  $50,000.

14.          Commitments:

On  March 25, 1997 the Company entered into a royalty agreement with Stanislaw
R.  Burzynski, M.D.,Ph.D., whereby Dr. Burzynski will undertake to continue to
be  the principal clinical investigator of FDA approved clinical trials, which
trials  are  necessary for obtaining FDA approval for interstate marketing and
distribution  of  antineoplastons.  Upon receiving FDA approval for interstate
marketing  and  distribution,  the  Company  agrees  to pay to Dr. Burzynski a
royalty  interest  equivalent  to  10%  (ten  percent)  of the Company's gross
income,  which  royalty  interest shall include gross receipts from all future
sales,  distributions  and  manufacture of antineoplastons. Dr. Burzynski will
have  the  right  to  either  produce  antineoplaston  products for use in his
medical  practice to treat up to 1,000 patients without paying any fees to the
Company,  or  purchase from the Company antineoplaston products for use in his
medical  practice  to  treat  up to 1,000 patients at a price of the Company's
cost  to  produce  the  antineoplaston  products  plus 10% (ten percent).  Dr.
Burzynski  will  also  have  the  right  to  either  lease or purchase all the
manufacturing  equipment  located at 12707 Trinity Drive, Stafford, Texas at a
fair  market  price.    The  Company  will  have  the  right  to  produce  all
antineoplaston  products  to  be  sold  or distributed in the U.S., Canada and
Mexico  for  the treatment of cancer.  The Company will also have the right to
lease  from  Dr.  Burzynski the entire premise located at 12707 Trinity Drive,
Stafford, Texas at arms-length terms at rates competitive with those available
in  the  market  at  that  time, provided that Dr. Burzynski does not need the
facility  for  his  use.


                                  SIGNATURES

     In accordance with Section 12 of the Securities Exchange Act of 1934, the
registrant  caused  this  registration statement to be signed on its behalf by
the  undersigned,  hereunto  duly  authorized.

Burzynski  Research  Institute,  Inc.


by:          /s/Stanislaw  R.  Burzynski
             ---------------------------
     Stanislaw  R.  Burzynski,  President,
Chairman  of  the  Board  and  Director

Date:          April  23,  1998

     Each  person  whose  signature appears below constitutes and appoints Dr.
Burzynski  his/her true and lawful attorney-in-fact and agent, with full power
of  substitution  and  resubstitution, severally, for him/her in his/her name,
place  and  stead,  in  any and all capacities, to sign any and all amendments
(including  post-effective  amendments) to this Registration Statement, and to
file  the  same,  with  all exhibits thereto and other documents in connection
therewith,  with  the  Securities  and Exchange Commission, granting unto said
attorney-in-fact and agent full power and authority to do and perform each and
every  act  and  thing  requisite  and  necessary  to be done in and about the
premises,  as fully to all intents and purposes as he/she might or could do in
person,  hereby  ratifying  and  confirming all that said attorney-in-fact and
agent  may  lawfully  do  or  cause  to  be  done  by  virtue  hereof.

     Pursuant  to  the  requirements  of  the  Securities  Act  of  1934, this
Registration  Statement  has been signed below by the following persons in the
capacities  and  on  the  dates  indicated.

/s/Stanislaw  R.  Burzynski                               Date: April 23, 1998
- ---------------------------
Stanislaw  R.  Burzynski
President,  Chairman  of  the  Board  and  Director

/s/Tadeusz  Bruzynski                                     Date: April 23, 1998
- ---------------------
Tadeusz  Burzynski
Senior  Vice  President  and  Director

/s/Dean  Mouscher                                         Date: April 23, 1998
- -----------------
Dean  Mouscher
Secretary

/s/Barbara  Burzynski                                     Date: April 23, 1998
- ---------------------
Barbara  Burzynski
Director

/s/Michael  H.  Driscoll                                  Date: April 23, 1998
- ------------------------
Michael  H.  Driscoll
Director

/s/Carlton  Hazelwood                                     Date: April 23, 1998
- ---------------------
Carlton  Hazelwood
Director





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