CYTOGEN CORP
424B2, 1996-01-30
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<TABLE> 
<S>                                               <C>   
PROSPECTUS SUPPLEMENT                             File No. 33-77396
(TO PROSPECTUS DATED APRIL 22, 1994)              Filed Pursuant to Rule 424(b)(2)
                                                  under the Securities Act of 1933
</TABLE> 


                                250,000 SHARES
                              CYTOGEN CORPORATION
                                 COMMON STOCK

                              __________________


               Pursuant to an Amended and Restated Investment Agreement (the
"Investment Agreement") between Cytogen Corporation (the "Company") and Fletcher
Capital Markets Inc. (the "Investor") dated as of May 6, 1994, the Company
agreed to sell to the Investor, subject to the terms and conditions of the
Investment Agreement, 1,400,000 shares of the Company's Common Stock, par value
$.01 per share (the "Common Stock"), 500,000 shares of which were purchased by
the Investor in May 1994 and 900,000 shares of which were purchased by assignees
of the Investor in August 1994. In connection with the Investment Agreement, the
Company granted to the Investor an option (the "Option") to purchase additional
shares of Common Stock (the "Option Shares") at a Per Share Exercise Price
defined therein as the product of (i) the average per share daily closing price
of the Common Stock as reported on the Nasdaq National Market for the period
beginning sixty (60) trading days prior to the date of the Election Notice and
ending on the Nasdaq trading day next preceding the date of the Election Notice
and (ii) 0.95. In August 1995, the Investor purchased 1,800,000 shares at a Per
Share Exercise Price of $4.058 per share pursuant to the exercise of the Option.
At that time, the Company and the Investor amended the Option to extend its term
until November 15, 1995 and thereunder, the Investor had the right to purchase
up to an additional 1,000,000 shares of Common Stock. In November 1995, the
Investor purchased 500,000 shares at a Per Share Exercise Price of $4.696 per
share pursuant to the exercise of the Option. At that time, the Company and the
Investor amended the Option to extend its term until February 15, 1996 and
thereunder, the Investor had the right to purchase up to an additional 1,000,000
shares of Common Stock. The Investor elected to exercise the Option on January
5, 1996 for the purchase of 750,000 shares at a Per Share Exercise Price of
$4.668 per share and on January 19, 1996 for the purchase of the remaining
250,000 shares at a Per Share Exercise Price of $4.879. The Company and the
Investor have agreed that the purchase and sale of the Option Shares will occur
on or about January 31, 1996.

               Persons who participate in the distribution of the Option Shares
may be deemed to be underwriters as the term is defined in the Securities Act of
1933, as amended (the "Securities Act"), and may be subject to the prospectus
delivery requirements thereunder. Any discounts or commissions received by them
from the Company and any profits on the resale of the Option Shares by them may
be deemed to be underwriting discounts and commissions under the Securities Act.
The Investor is entitled under the Investment Agreement to indemnification
against or contribution toward certain civil liabilities, including liabilities
under the Securities Act. The Investor has advised the Company that it believes
that it is not a statutory underwriter under the Securities Act.

               On January 29, 1996, the last reported sale price of the Common
Stock, as reported on Nasdaq was $7.875 per share.

                              __________________

         THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE
           SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES
                 COMMISSION NOR HAS THE SECURITIES AND EXCHANGE
                 COMMISSION OR ANY STATE SECURITIES COMMISSION
                    PASSED UPON THE ACCURACY OR ADEQUACY OF
                    THIS PROSPECTUS.  ANY REPRESENTATION TO
                      THE CONTRARY IS A CRIMINAL OFFENSE.

                              __________________
 
<TABLE> 
<CAPTION> 
==============================================================================
                                      Sales Price    Proceeds To Company (1)
                                      -----------    -------------------
- ------------------------------------------------------------------------------
<S>                                   <C>            <C>
Per share.................              $ 4.879               $ 4.879
- ------------------------------------------------------------------------------
Total.....................             $1,219,750            $1,219,750
==============================================================================
</TABLE>

(1)  Before deducting estimated expenses of approximately $5,000 payable by the
     Company.
          The date of this Prospectus Supplement is January 30, 1996.
<PAGE>
 
                                   DILUTION

               The net tangible book value per share of the Common Stock at
September 30, 1995 was $0.368. Without taking into account any change in the
Company's net tangible book value after September 30, 1995, other than giving
effect to the issuance and sale of the Option Shares at $4.879 per share as
shown on the cover page (after deducting estimated expenses), the pro forma net
tangible book value per share of the Common Stock would have been $0.400. This
represents an immediate increase in net tangible pro forma book value per share
of $0.032 to present stockholders and an immediate dilution of $4.479 per share
to the Investor. The following table illustrates the per share effect of this
dilution on the Investor's purchase of Common Stock:


<TABLE>
<CAPTION>
<S>                                                                   <C>
  Sales price of Common Stock.......................................  $4.879
     Net tangible book value before sale...................  $0.368
     Increase attributable to payments by the Investor.....  $0.032
 
  Pro forma net tangible book value after sale /(1) (2)/............  $0.400
 
  Dilution of the Investor..........................................  $4.479
</TABLE>

                              RECENT DEVELOPMENTS

          On November 20, 1995, the Company issued and sold 1,256,565 shares of
Common Stock in a private placement transaction pursuant to Regulation S of the
Securities Act for an aggregate purchase price of approximately $5,000,000 (the
"Private Placement") and, in connection therewith, the Company was granted the
right to put to that investor, until March 19, 1996 (unless extended), that
number of shares equal to $5 million divided by a formula purchase price.

          On November 27, 1995, the Company announced that the U.S. Food and
Drug Administration ("FDA") has approved the Company's Product License
Application supplement expanding the approved indications for the Company's
OncoScint CR/OV product to include repeat administration of the product.
OncoScint CR/OV, a monoclonal antibody-based cancer imaging agent for colorectal
and ovarian cancer, was approved by FDA in December 1992. The initial approval
limited the product to a single administration indication. The approved
supplement extends the prior indication to include readministration to human
anti-murine antibody (HAMA)-negative patients who are at risk for recurrence of
their cancer.

          In December 1995, the Company and Elan Corporation ("Elan") entered
into a Research and Development Agreement pursuant to which the Company's
Genetic Diversity Library technology ("GDL") will be combined with Elan's drug
delivery system technology to collaboratively develop orally administered
products which transport drugs through certain biological barriers within the
body. Elan has been granted an option for the worldwide licensing rights to any
products so developed and the Company will receive royalties based on sales, if
any, of such products. Elan will provide the funding necessary for both
companies to fulfill their respective obligations under the agreement. The total
cost for the first year is not expected to exceed $3.0 million, of which up to
$1.5 million shall be paid to the Company.


_____________________________

1.   Excludes 4,285,000 shares of Common Stock issuable upon exercise of
     outstanding warrants, 2,011,748 shares of Common Stock issuable pursuant to
     outstanding contingent value rights to purchase Common Stock, 4,191,709
     shares of Common Stock issuable upon the exercise of options outstanding
     under stock option plans and issuable to Fletcher Fund, L.P. in connection
     with the Company's exercise of certain put rights, and additional shares
     issuable upon exercise of the put rights described above.

2.   Also excludes (a) 4,713,565 shares of Common Stock issued in connection
     with the merger of Cellcor, Inc., a Delaware corporation, with and into a
     wholly-owned subsidiary of the Company ("Cellcor Merger") and 5,144,388
     shares issued in the related Subscription Offering, (b) 1,250,000 shares of
     Common Stock issued pursuant to the exercise of the Option by the Investor
     in November 1995 and on January 17, 1996, as described above (the "Option
     Exercise") and (c) 1,256,565 shares of Common Stock issued in the Private
     Placement.  The above calculation does not give effect to the immediate
     charge of $26.4 million for acquired research and development relating to
     the Cellcor Merger.  The net effect of the Cellcor Merger, the Option
     Exercise and the Private Placement on the Investor is to decrease the pro
     forma net tangible book value by $0.016 per share to $0.384 per
     share.


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