CYTOGEN CORP
8-K, 1998-06-08
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                         Conformed
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                   SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C. 20549
                                
                                
                                 FORM 8-K
                                
                              CURRENT REPORT
                                
                     Pursuant to Section 13 or 15(d)
                 of the Securities Exchange Act of 1934
                                
                                
    Date of Report (Date of earliest event reported): June 8, 1998
                                                      ------------
                            
                             CYTOGEN CORPORATION               
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          (Exact name of registrant as specified in its charter)
                                
                                
   Delaware                   333-02015                   22-2322400 
- ---------------              -----------                -------------
(State or other              (Commission                (IRS Employer
jurisdiction of                File No.)              Identification No.)
Incorporation or
Organization)


 600 College Road East, CN 5308, Princeton, New Jersey         08540-5308   
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        (Address of principal executive offices)               (Zip Code)    
                                
                                
    Registrant's telephone number, including area code: (609) 987-8200
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Item 5.  Other Events.
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     On June 8, 1998, CYTOGEN Corporation issued the attached press release.

Item 7.  Exhibits.
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99.1 Press release issued by CYTOGEN Corporation on June 8, 1998





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                                SIGNATURES
                                
     Pursuant to the requirements of the Securities Exchange Act
of 1934, the Registrant has duly caused this report to be signed
on its behalf by the undersigned, thereunto duly authorized.

                                   CYTOGEN CORPORATION



                              By   /s/ Donald F. Crane, Jr.       
                                   --------------------------------            
                                   Name:  Donald F. Crane, Jr.
                                   Title: Vice President General Counsel and
                                          Corporate Secretary
     
Date: June 8, 1998 





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                               EXHIBIT INDEX
                                
                                
Number                           Description                          Page

 99.1           Press Release issued by CYTOGEN Corporation on 
                June 8, 1998                                            5





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      Contacts: Corporate Communications     Angela Bitting
                    CYTOGEN Corporation      Russell-Welsh, Inc.
                    (609) 987-8221           (650) 312-0700 Ext. 15

FOR  IMMEDIATE  RELEASE
- -----------------------
 
CYTOGEN  ANNOUNCES  PLANS  FOR  NEXT  PHASE  OF  MARKETING  FOR 
                           QUADRAMET 
                                
     --Receipt of $3.8 Million Payment from DuPont Merck--

PRINCETON, N.J., -- June 8, 1998 -- CYTOGEN Corporation (NASDAQ: CYTO)
today announced plans for the next phase of marketing for Quadramet 
for the treatment of bone pain from cancer which has spread to the
bone.  In addition, the Company also announced the receipt of a
payment for Quadramet, totaling $3.8 million, from DuPont Merck.

The license agreement between CYTOGEN and DuPont Merck signed in
December 1994 has now been terminated and DuPont Merck has begun
efforts to identify and select a new partner to work with CYTOGEN so
that the potential of Quadramet can be fully realized.  CYTOGEN and
DuPont Merck anticipate that DuPont Merck will manufacture Quadramet
over the next two years and CYTOGEN is expanding its own sales efforts
to include Quadramet.  Through their own technical specialists,
CYTOGEN will immediately inform the physicians at more than 200
clinical sites that are certified to use ProstaScint , CYTOGEN's
prostate cancer imaging agent, about the benefits of Quadramet. 
CYTOGEN will also begin marketing directly to all national cancer
centers.  CYTOGEN stated that near-term royalty revenues are expected
to be affected adversely since the minimum royalty arrangement is
discontinued and booked revenues will be based on actual sales rather
than minimum royalties.  As previously reported, actual sales have to
date been substantially less than minimum royalties.

CYTOGEN indicated that achieving market penetration with Quadramet as
early as possible and bringing this important product to cancer
patients is essential to the success of this product.  John E.
Bagalay, Jr., president and chief executive officer of CYTOGEN stated,
"Quadramet is a product with tremendous potential." 

DuPont Merck is a worldwide, research-based pharmaceutical and
radiopharmaceutical company established in 1991 as a partnership
between DuPont and Merck and Co.  The Company is headquartered in
Wilmington, Delaware; the Radiopharmaceuticals Division is
headquartered in North Billerica, Massachusetts.  The Company markets
its products under the DuPont Pharma name.

CYTOGEN is a biopharmaceutical company engaged in the development,
manufacture, and commercialization of products for the targeted
delivery of diagnostics and therapeutic substances directly to disease
sites.  CYTOGEN has demonstrated its ability to develop new technology
from early discovery through clinical development, regulatory approval
and commercial scale biologic manufacturing.

Information in this press release, which is not historical, is forward
looking and involves risks and uncertainties.  Actual results may
differ materially, for reasons discussed in CYTOGEN's filings with the
Securities and Exchange Commission, including risks related to the
ability to find a suitable partner for marketing Quadramet, and
commercial acceptance of  CYTOGEN's products.

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