CYTOGEN CORP
DEF 14A, 1999-05-13
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                               CYTOGEN CORPORATION
                        600 COLLEGE ROAD EAST - CN 5308
                        PRINCETON, NEW JERSEY 08540-5308

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 16, 1999

To the Stockholders of
Cytogen Corporation:



         NOTICE IS HEREBY  GIVEN that the  Annual  Meeting  of  Stockholders  of
CYTOGEN CORPORATION (the "Company") will be held on Wednesday,  June 16, 1999 at
9:00 a.m. at The Holiday Inn Princeton,  Route One at Ridge Road, Princeton, New
Jersey 08540 for the following purposes:


         1.  The election of six (6) directors to serve until the next annual 
meeting of stockholders;

         2. To consider  and vote on approval of the 1999  Cytogen  Non-Employee
Director Stock Option Plan; and

         3. To transact  such other  business as may properly be brought  before
the meeting or any adjournments thereof.

         The Board of  Directors  has fixed the close of  business  on April 23,
1999,  as the record  date for  determination  of the  stockholders  entitled to
notice of and to vote at the Annual  Meeting,  and only holders of record of the
Company's Common Stock on said date will be entitled to receive notice of and to
vote at the meeting.

         Stockholders  are cordially  invited to attend the meeting.  Whether or
not you plan to attend  the  meeting,  please  mark,  sign,  date and return the
enclosed  Proxy.  The giving of your Proxy will not affect your right to vote in
person in the event you find it convenient to attend the meeting. You may revoke
the Proxy at any time before the closing of the polls at the meeting.

         ATTENDANCE AT THE ANNUAL  MEETING WILL BE LIMITED TO  STOCKHOLDERS  AND
INVITED GUESTS OF THE COMPANY.


                                              By Order of the Board of Directors

                                                            Donald F. Crane, Jr.
Princeton, New Jersey                                        Corporate Secretary
May 13, 1999



 PLEASE SIGN, DATE AND RETURN YOUR PROXY CARD PROMPTLY IN THE ENCLOSED ENVELOPE.

<PAGE>




                                                                  

                               CYTOGEN CORPORATION
                               -------------------

                                 PROXY STATEMENT
                                 ---------------
GENERAL

         This Proxy Statement is being mailed to stockholders  beginning May 13,
1999 in connection  with the  solicitation  by the Board of Directors of Cytogen
Corporation,  a Delaware  Corporation (the "Company" or "Cytogen") of proxies to
be voted at the 1999 Annual  Meeting of  Stockholders  to be held at The Holiday
Inn  Princeton,  Princeton,  New Jersey,  on June 16,  1999 at 9:00 A.M.  (local
time),  and at any  adjournment  thereof,  for the  purposes  set  forth  in the
attached Notice of Annual Meeting of Stockholders.

         When proxies in the enclosed form are returned properly  executed,  the
shares represented  thereby will be voted at the meeting and, where instructions
have been given by the stockholder,  will be voted in accordance  therewith.  If
the stockholder does not otherwise  specify,  the  stockholder's  shares will be
voted  for the  election  of the  listed  nominees  and in  accordance  with the
directors' recommendations on the other subject listed on the proxy card. If any
other matter is properly presented for action at the meeting,  the persons named
in the enclosed form of proxy will vote on such matter in their discretion.  Any
proxy may be revoked by the  stockholder,  either by  attending  the meeting and
voting in  person or by  submitting  a  revocation  in  writing  to the  Company
(including  a subsequent  signed  proxy) at any time prior to the closing of the
polls at the meeting.

STOCKHOLDER VOTE REQUIRED

         To be elected a director,  a nominee must receive the affirmative  vote
of a  plurality  of shares  present  in person  or  represented  by proxy at the
meeting and  entitled to vote in the  election of  directors.  A plurality  vote
means that the six individuals who receive the largest number of votes cast will
be  elected as  directors.  Withheld  votes  will not affect the  outcome of the
election of directors.  Other than the election of directors,  each matter to be
submitted to the stockholders requires the affirmative vote of a majority of the
votes cast at the meeting.  For purposes of determining the number of votes cast
with respect to a  particular  matter,  only those cast "For" or  "Against"  are
included.  Properly  returned  proxies  which  withhold  authority  to vote  for
directors  or  abstain  (broker  non-votes)  will be  counted  for  purposes  of
determining if a quorum is present for the annual meeting.

         The Company's  auditors are Arthur  Andersen LLP. A  representative  of
Arthur Andersen LLP will be present at the meeting,  will have an opportunity to
make a statement if the  representative  desires to do so, and will be available
to respond to appropriate questions.

         A COPY OF THE COMPANY'S  ANNUAL REPORT TO THE  SECURITIES  AND EXCHANGE
COMMISSION  ON FORM 10-K FOR THE YEAR ENDED  DECEMBER  31, 1998 WILL BE PROVIDED
WITHOUT  CHARGE TO ANY  STOCKHOLDER  UPON WRITTEN  REQUEST.  REQUESTS  SHOULD BE
DIRECTED TO  CORPORATE  COMMUNICATIONS,  CYTOGEN  CORPORATION,  600 COLLEGE ROAD
EAST-CN 5308, PRINCETON, NJ 08540-5308.

OUTSTANDING SHARES, VOTING RIGHTS AND PRINCIPAL STOCKHOLDERS

         Holders of record of outstanding  shares of the Company's  Common Stock
$.01 par value ("Common  Stock") at the close of business on April 23, 1999 will
be  entitled  to  notice  of and to one vote per  share so held of record on all
business at the Annual Meeting. On the record date, there were 65,105,097 shares
of Common  Stock  outstanding.  Votes  cast in person or by proxy at the  Annual
Meeting will be  tabulated by the  Inspector(s)  of Election  appointed  for the
annual  meeting  who will  determine  whether or not a quorum is present and the
results of the votes with respect to each matter.


<PAGE>


         The following table sets forth certain information as of March 31, 1999
(unless noted), with respect to the beneficial ownership of the Company's Common
Stock by each  person  known by the Company to be the  beneficial  owner of more
than 5% of its  outstanding  Common  Stock,  by each  director  and  nominee for
election  as a  director,  by  each  executive  officer  named  in  the  Summary
Compensation  Table,  and by all  executive  officers and  directors as a group.
Except as indicated  in the  footnotes  to the table,  the persons  named in the
table have sole voting and investment power with respect to all shares of Common
Stock beneficially owned by them.

<TABLE>
<CAPTION>
                                                         NUMBER OF SHARES
                                                         OF COMMON STOCK         PERCENT
NAME AND ADDRESS OF BENEFICIAL OWNER(1)                 BENEFICIALLY OWNED       OF CLASS 
- ---------------------------------------                 ------------------       -------- 

<S>                                                           <C>                  <C>   
Henry L. Hillman,
Elsie Hilliard Hillman and
C.G. Grefenstette, Trustees
2000 Grant Building
Pittsburgh, PA  15219 (2).................................... 8,218,191            12.62%

State of Wisconsin Investment Board
121 E. Wilson Street
Madison, WI  53702........................................... 5,462,834             8.40%

Ronald J. Brenner
One Tower Bridge
Suite 1350
100 Front Street
West Conshohocken, PA  19428 (4)(5).......................... 3,812,909             5.85%

Hillman Medical Ventures Partnerships
824 Market Street, Suite 900
Wilmington, DE  19801 (3).................................... 3,713,909             5.70%

Hal S. Broderson
One Tower Bridge
Suite 1350
100 Front Street
West Conshohocken, PA  19428 (4)............................. 3,715,009             5.70%

Charles G. Hadley
One Tower Bridge
Suite 1350
100 Front Street
West Conshohocken, PA  19428 (4)............................. 3,714,159             5.67%

Directors and Executive Officers

Thomas J. McKearn (5)........................................   710,463             1.08%
John D. Rodwell (5)(6).......................................   325,300                *
H. Joseph Reiser (7).........................................   352,000                *
Graham S. May (5)............................................   121,743                *
Donald F. Crane, Jr. (5) ....................................   115,753                *
Robert J. Broeze (5).........................................   104,309                *
James A. Grigsby.............................................    61,200                *
John E. Bagalay, Jr. (5).....................................    60,134                *
Robert F. Hendrickson (5) ...................................    28,800                *
Stephen K. Carter (7)........................................     3,000                *

                                       2

<PAGE>
All executive officers
  and directors as a group (14 persons) (5).................. 5,853,534             8.99%
- -----------------
 *Indicates amount is less than 1%.
</TABLE>

 (1) All  information  with respect to  beneficial  ownership of shares is based
upon filings made by the  respective  beneficial  owners with the Securities and
Exchange  Commission or information  provided by such  beneficial  owners to the
Company.  Percent  of class  for each  person  and all  executive  officers  and
directors as a group is based on shares of Common Stock outstanding on March 31,
1999 and includes shares subject to options held by the individual or the group,
as applicable,  which are  exercisable or as become  exercisable  within 60 days
following such date.

 (2) Includes  116,325 shares of Common Stock held by the Henry L. Hillman Trust
U/A dated  November 18, 1985 (the "HLH  Trust"),  20,625  shares of Common Stock
held by Hillman  1984  Limited  Partnership  ("Hillman  1984"),  4,125 shares of
Common Stock held by HCC Investments,  Inc. ("HCC"),  4,363,207 shares of Common
Stock held by Juliet  Challenger,  Inc. ("JCI"),  367,445 shares of Common Stock
held by Hillman  Medical  Ventures  1989 L.P.  ("HMV 1989"),  176,470  shares of
Common Stock held by Hillman  Medical  Ventures 1990 L.P. ("HMV 1990"),  486,622
shares of Common Stock held by Hillman Medical  Ventures 1991 L.P. ("HMV 1991"),
110,522 shares of Common Stock held by Hillman Medical  Ventures 1992 L.P. ("HMV
1992"),  1,094,700  shares of Common Stock held by Hillman Medical Ventures 1994
L.P. ("HMV 1994"),  and 1,478,150 shares of Common Stock held by Hillman Medical
Ventures 1995 L.P.  ("HMV  1995").  JCI, HCC, and  Wilmington  Securities,  Inc.
(which (i) owns Hillman  Properties  West,  Inc.,  the sole  general  partner of
Hillman 1984, and (ii) is the sole general partner of Hillman/Dover L.P., one of
the general partners of HMV 1989, HMV 1990, HMV 1991, HMV 1992, HMV 1994 and HMV
1995   (collectively,   "Hillman  Medical  Ventures"))  are  private  investment
companies owned by Wilmington Investments, Inc., which, in turn, is owned by The
Hillman  Company.  The Hillman  Company is a private firm engaged in diversified
investments and operations,  which is controlled by the HLH Trust.  The trustees
of the HLH  Trust  are  Henry  L.  Hillman,  Elsie  Hilliard  Hillman  and  C.G.
Grefenstette (the "HLH Trustees").  Consequently,  the HLH Trustees share voting
and investment power with respect to the shares held of record by the HLH Trust,
JCI, HCC, Hillman 1984, and Hillman Medical Ventures and may be deemed to be the
beneficial  owners of such  shares.  Does not  include an  aggregate  of 155,100
shares of Common  Stock  held by four  irrevocable  trusts  for the  benefit  of
members of the Hillman family  (collectively,  the "Family Trusts"), as to which
shares  the HLH  Trustees  (other  than Mr.  Grefenstette)  disclaim  beneficial
interest.  C.G.  Grefenstette  and Thomas G.  Bigley are  trustees of the Family
Trusts and, as such,  share voting and investment  power over the shares held by
the Family Trusts.

 (3) Includes 367,445 shares of Common Stock held by HMV 1989, 176,470 shares of
Common Stock held by HMV 1990,  486,622 shares of Common Stock held by HMV 1991,
110,522  shares of Common  Stock  held by HMV 1992,  1,094,700  shares of Common
Stock held by HMV 1994 and 1,478,150 shares of Common Stock held by HMV 1995.

 (4) Includes  3,713,909 shares held by Hillman Medical  Ventures.  Each of Drs.
Broderson and Brenner and Mr. Hadley is a general  partner of Cashon  Biomedical
Associates,  L.P.,  which is a general partner of the Hillman  Medical  Ventures
Partnerships  and,  therefore,  may be deemed to be the beneficial owner of such
shares.  Drs.  Broderson and Brenner and Mr. Hadley share voting and  investment
power with respect to the shares held by Hillman  Medical  Ventures and disclaim
beneficial  ownership  of the  1,992,715  shares  beneficially  owned by the HLH
Trustees,  Hillman 1984,  HCC, JCI and the Family  Trusts  referred to in note 2
above.

 (5) Includes  shares of Common Stock which the named  persons have the right to
acquire upon the exercise of stock options, within sixty days of March 31, 1999,
as follows: Dr. Reiser: 350,000; Dr. McKearn: 363,000; Dr. Rodwell: 260,300; Dr.
May 121,743; Dr. Brenner:  10,800; Dr. Bagalay:  49,134; Mr. Grigsby: 7,200; Mr.
Hendrickson:  14,800;  Mr. Crane:  109,429;  and Dr. Broeze:  99,000.  The group
number  includes  the shares of Common  Stock which the named  persons and other
executive  officer have the right to acquire upon the exercise of stock options,
within sixty days of March 31, 1999.  Dr.  McKearn and Dr.  Broeze are no longer
employed by the Company.

 (6) Includes  5,000  shares held by Dr.  Rodwell's  wife as  custodian  for two
children  under  the  Pennsylvania  Uniform  Gift to  Minors  Act.  Dr.  Rodwell
disclaims beneficial ownership of the 5,000 shares held by his wife.

(7) Dr.  Reiser was  elected  President  and Chief  Executive  Officer  and as a
director on August 24, 1998;  Dr.  Carter was elected as a director on September
14, 1998. Dr. Carter purchased shares in May, 1999.

                                       3
<PAGE>

PROPOSAL ONE.     ELECTION OF DIRECTORS

NOMINEES FOR DIRECTORS

         The persons named in the accompanying  form of proxy intend,  except as
otherwise  directed,  to vote for the  election as directors of the six nominees
listed below,  each for a term expiring at the next Annual  Meeting or until his
or her successor is duly elected and qualified.  All nominees are now serving as
directors of the Company, and all have informed management that they are willing
to serve as directors of the Company.  If any of the nominees  should decline or
be unable to act as a  director,  the  persons  named as  proxies in the form of
proxy  will  vote  in  accordance  with  their  best  judgment  and  shall  have
discretionary authority to vote for a substitute nominee. The Board of Directors
has fixed its present size at, and for the  purposes of this meeting  authorized
the election of, six directors.

         The  following  sets forth certain  information  as to the nominees for
directors of the Company.

         James A. Grigsby,  56,  Chairman of the Board of Directors,  has been a
director  of the  Company  since May 1996 and  Chairman  since June 1998.  Since
April,  1999,  Mr.  Grigsby  has been  affiliated  with the  consulting  firm of
Nachman, Hays & Associates. Previously, since 1994, Mr. Grigsby was president of
Cancer Care  Management  LLC, a consulting  firm providing  consulting  services
regarding cancer disease management  issues.  From 1989 to 1994, Mr. Grigsby was
President  of  CIGNA  Corporation's  International  Life and  Employee  Benefits
Division,  which operated in over 20 countries worldwide, and during that period
also served as the head of CIGNA's  national  health care sales force.  Prior to
that  time,  since  1978,  he held a number of  executive  positions  with CIGNA
Corporation.  Mr.  Grigsby  received a B.A.  degree in  Mathematics  from Baylor
University and is a Fellow of the Society of Actuaries.

     John E. Bagalay,  Jr., 65, has been a director of the Company since October
1995.  Dr.  Bagalay  was a director of Cellcor,  Inc.  ("Cellcor")  prior to the
Company's acquisition of Cellcor in October 1995. He was interim President,  CEO
and Chief Financial  Officer of the Company from January - August,  1998. He has
been Senior Advisor to the Chancellor, Boston University since January, 1998. He
has been a director,  Chief  Operating  Officer and Chief  Financial  Officer of
Eurus Technologies, Inc. since January, 1999. He served as the Managing Director
of  Community   Technology  Fund,  the  venture  capital   affiliate  of  Boston
University,  from September 1989 until January 1998.

     Dr.  Bagalay  has  also  served  as  General  Counsel  for  Texas  Commerce
Bancshares and for Lower Colorado River Authority, a regulated electric utility.
Dr.  Bagalay  currently  also serves on the boards of  directors of Wave Systems
Corporation  and AES, Inc. Dr. Bagalay holds a B.A. in Politics,  Philosophy and
Economics and a Ph.D. in Political  Philosophy from Yale University,  and a J.D.
from the University of Texas.

         Ronald J. Brenner, 65, has been a director of the Company since October
1995. Dr. Brenner was President and Chief Executive Officer of Cellcor from July
1995 until the Company's acquisition of Cellcor in October 1995. Dr. Brenner has
been a Vice President of Hillman Medical Ventures, Inc., a venture capital firm,
and a general  partner of the managing  general  partner of the Hillman  Medical
Ventures  partnerships  since 1989. From 1984 to 1988, Dr. Brenner was President
and Chief  Executive  Officer of Cytogen.  Prior to 1984, he was Vice President,
Corporate  External  Research,  at  Johnson &  Johnson,  a major  pharmaceutical
company,   and  also  served  as  Chairman  of  McNeil   Pharmaceutical,   Ortho
Pharmaceutical  Corp. and the Cilag  Companies,  all  subsidiaries  of Johnson &
Johnson.  Dr.  Brenner  received  a B.S.  in  Pharmacy  from the  University  of
Cincinnati,  and an M.S. and Ph.D., both in Pharmaceutical  Chemistry,  from the
University of Florida.

     Stephen K. Carter,  61, has been a director of the Company since September,
1998.  Dr.  Carter was Senior Vice  President  of Research  and  Development  at
Boehringer Ingelheim  Pharmaceuticals,  Inc. from 1995 to 1997. Prior to joining
Boehringer,  Dr. Carter was Senior Vice President of Worldwide Clinical Research
and Development at Bristol-Myers  Squibb Company.  From 1976 to 1982, Dr. Carter
served as Director of the Northern  California Cancer Institute.  Dr. Carter was
also  appointed  to President  Clinton's  panel for AIDS drug  development.  Dr.
Carter also is a director of Allos  Therapeutics and Alfacell  Corporation.  Dr.
Carter  received an AB in History from Columbia  College and an MD from New York
Medical College.  He completed a medical  internship and residency at Lenox Hill
Hospital.

                                       4
<PAGE>

     Robert F. Hendrickson,  66, became a director of the Company in March 1995.
Since 1990,  Mr.  Hendrickson  has been a consultant to the  pharmaceutical  and
biotechnology industries on strategic management and manufacturing issues with a
number  of  leading  biotechnology  companies  among his  clients.  Prior to his
retirement in 1990, Mr. Hendrickson was Senior Vice President, Manufacturing and
Technology  for Merck & Co.,  Inc. He is the Chairman of the Board of Envirogen,
Inc., a director of The Liposome Company, Inc. and Unigene,  Inc., and a trustee
of the Carrier  Foundation,  Inc. Mr.  Hendrickson  received an A.B. degree from
Harvard  College  and an M.B.A.  from the  Harvard  Graduate  School of Business
Administration.

     H. Joseph Reiser,  52, joined CYTOGEN in August 1998 as President and Chief
Executive Officer and as a member of the Board of Directors.  Most recently, Dr.
Reiser was Corporate Vice President and General  Manager,  Pharmaceuticals,  for
Berlex Laboratories Inc., the U.S. subsidiary of Schering AG. During his 17 year
tenure at Berlex,  Dr.  Reiser  held  positions  of  increasing  responsibility,
serving as the first President of Schering  Berlin's Venture  Corporation,  Vice
President,   Technology  and  Industry  Relations,  and  Vice  President,   Drug
Development  and  Technology.  Dr. Reiser  received his Ph.D. in Physiology from
Indiana  University  School of  Medicine,  where he also  earned  his Master and
Bachelor of Science degrees.

MEETINGS AND COMMITTEES

         During 1998, the Board of Directors met twenty-four (24) times. Each of
the incumbent  directors  attended at least 75% of the aggregate of all meetings
of the Board of Directors  and  committees  of which he was a member held during
the period he served on the Board of Directors or such committee.

         The  standing  committees  of the  Board  of  Directors  are the  Audit
Committee, the Compensation Committee, the Finance Committee, and the Nominating
Committee.

         The Audit  Committee  recommends the selection of a firm of independent
auditors  to the Board of  Directors  for  purposes of  auditing  the  Company's
financial  statements;  reviews the audit with the auditors and management;  and
consults with the auditors and  management  regarding  risk  management  and the
adequacy  of  financial  and  accounting  procedures  and  controls.  The  Audit
Committee  met five (5) times  during  1998.  Its current  members are Robert F.
Hendrickson (Chairman), John E. Bagalay, Jr., and Stephen K. Carter.

         The Compensation  Committee  evaluates the performance of the Company's
Chief Executive  Officer and recommends his  compensation to the Board annually;
oversees the  administration of the Company's stock option plans;  recommends to
the  Board of  Directors  compensation  for  executive  officers  and  other key
employees  of  the  Company;  and  reviews  the  Company's  compensation  policy
generally.  The  Compensation  Committee  met three (3) times during  1998.  Its
current members are Ronald J. Brenner (Chairman), and Robert F. Hendrickson.

     The Finance  Committee  (chartered  as a standing  committee  during  1998)
reviews and  monitors the  financial  planning  and  financial  structure of the
Company to accommodate the operating requirements and strategic objectives.  The
Finance  Committee met one (1) time during 1998. Its current members are John E.
Bagalay, Jr. (Chairman), James A. Grigsby, and H. Joseph Reiser.

         The Nominating  Committee is responsible for investigating,  recruiting
and interviewing potential candidates for election to the Board of Directors and
for formally  nominating for  consideration by the full Board of Directors those
individuals  deemed worthy by the Nominating  Committee of election to the Board
of Directors.  The Nominating  Committee met in connection  with approval of the
slate of nominees  for  election  as  directors  at the 1998  Annual  Meeting of
Stockholders  and in connection  with the elections of Dr. Reiser and Dr. Carter
to the Board of Directors.  Its current members are James A. Grigsby  (Chairman)
and H. Joseph Reiser.  The Nominating  Committee will consider  nominees for the
Board of  Directors  suggested  by  stockholders  whose names are  submitted  in
writing  to the  Nominating  Committee  in care of the  Office of the  Corporate
Secretary of the Company.

          THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR EACH
                          OF THE NOMINEES LISTED ABOVE


                                       5

<PAGE>


DIRECTORS' COMPENSATION

         Each  director  who is not also an  officer  of the  Company is paid an
annual retainer of $8,000,  plus $1,000 for each Board meeting attended ($500 if
participation  was by telephone).  Any non-employee  director who also chaired a
Board  committee  received  an  additional  annual fee of  $1,000.  Non-employee
directors  receive  $250 for each  committee  meeting  attended,  but receive no
additional  retainer  for  committee  membership.   Members  of  the  Nominating
Committee do not receive any  compensation  for serving on that  committee.  The
Chairman  of the  Board  (who  is  not an  employee  of the  Company)  currently
receives,  based upon significant time spent on Company business,  an additional
annual retainer of $50,000 and an annual option grant for the purchase of 15,000
shares of the Company's common stock.. The additional retainer contemplates four
days per month  substantially  given to Company  business  by the  Chairman;  an
amount of $1,500 per day is paid to the  Chairman for  additional  days in which
the significant part of the day is devoted to Company matters.

         Pursuant to the 1988 Stock Option Plan for Non-Employee  Directors (the
"Directors  Plan"),  upon initial  appointment to the Board,  each  non-employee
director of the Company was granted an option to purchase 8,000 shares of Common
Stock.  Following  each  annual  stockholders'  meeting  of  the  Company,  each
non-employee director who was re-elected at that stockholders' meeting was under
that Plan granted an option to purchase  6,000 shares of Common  Stock.  Options
granted under the Directors Plan are exercisable at a price equal to the average
of the high and low sale  prices of the Common  Stock as  reported on the Nasdaq
National Market on the date of grant, and vest (i.e., first become  exercisable)
over five  years at a rate of 20% for each year of service  completed  after the
option grant. Each director's outstanding options become immediately exercisable
in full (i) upon the occurrence of a change of control of the Company, (ii) upon
death or  disability  or (iii)  upon  resignation  or  retirement  after age 65.
Options granted under the Directors Plan are granted  automatically  and without
the need for  further  action  by the  Company,  the Board of  Directors  or the
Company's stockholders.  This Plan expires at this Annual Meeting and no further
grants will be made;  however,  options  previously granted under this Plan will
remain outstanding.  The Shareholders are being asked at this meeting to vote on
a replacement  plan, the Cytogen  Corporation 1999  Non-employee  Director Stock
Option Plan (see Proposal Two below).

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The  members  of the  Compensation  Committee  during  1998 were  Ronald J.
Brenner (Chairman),  and Robert F. Hendrickson.  Neither of these gentlemen were
officers  or  employees  of  the  Company  while  serving  on  the  Compensation
Committee.  Dr.  Brenner served as the Company's  President and Chief  Executive
Officer from 1984 to 1988.

PROPOSAL TWO.  APPROVAL OF THE CYTOGEN CORPORATION 1999 NON-EMPLOYEE DIRECTOR 
STOCK OPTION PLAN.

         The Board of  Directors  adopted the Cytogen  Corporation  Non-Employee
Director Stock Option Plan (the "Director  Option Plan") at its regular  meeting
on April 1, 1999, subject to the approval of the shareholders of the Company. At
the Annual  Meeting  shareholders  will be asked to approve the Director  Option
Plan, and the Board  recommends  that it be approved.  The Director  Option Plan
will, if approved,  replace the 1988  Non-employee  Director  Stock Option Plan,
which by its terms expires at the 1999 Annual Meeting of Shareholders.

         The Board of Directors and management  believe that the Director Option
Plan will help  attract and retain  superior  directors  and  promote  long-term
growth and profitability by further aligning director and shareholder interests.
The  affirmative  vote of a majority  of the  Shares  cast on this  Proposal  is
required for its adoption.

         A summary of the  essential  features  of the  Director  Option Plan is
provided  below,  but is qualified in its entirety by reference to the full text
of the Director  Option  Plan,  which was filed  electronically  with this Proxy
Statement  with the  Securities  and Exchange  Commission.  The full text of the
Director  Option  Plan is not  included  in the  printed  version  of this Proxy
Statement.  All  defined  terms  used below  have the  meaning  set forth in the
Director Option Plan, unless otherwise indicated.


                                       6
<PAGE>


PURPOSE

         The Director Option Plan is intended to promote the interest of Cytogen
by affording  Non-Employee  Directors an  opportunity  to acquire a  proprietary
interest in the Company, in order to attract and retain Non-Employee  Directors,
to provide them with long term financial incentives to increase the value of the
Company,  and to provide  them with a stake in the future of the  Company  which
corresponds to the stake of each of the Company's shareholders.

SHARES SUBJECT TO PLAN

         The aggregate  number of shares of Cytogen common stock ("Shares") with
respect to which the grant  ("Grants")  of Stock Options may be made is 500,000.
Any Shares  subject to a Grant shall again  become  available  for use after the
exchange, cancellation, forfeiture or expiration of such Grant as if such Shares
had never been subject to a Grant.

EFFECTIVE DATE AND DURATION

         The effective date of the Director  Option Plan shall be June 16, 1999.
The Plan shall  terminate on June 16, 2009,  unless  earlier  terminated  by the
Board of  Directors.  No Stock  Options shall be granted after the date on which
this Plan  terminates.  The  terms of this  Plan,  and any terms and  conditions
applicable  to the Stock Options  granted prior to such date,  shall survive the
termination of the Plan and continue to apply to such Stock Options.

ADMINISTRATION

         The  Plan is to be  administered  by the  Compensation  Committee  (the
"Committee") of the Board of Directors.  The Committee shall consist of two more
non-employee  directors of the Company, who shall be appointed by the Board. The
members shall also be qualified as outside  directors as contemplated by Section
162(m) of the Internal Revenue Code, as amended.

         The Committee  shall,  subject to the provisions of the Director Option
Plan,  (a)  effect  all  Grants,  (b)  determine  or  provide  for the terms and
conditions of Grant  agreements and other forms, (c) interpret the Plan, and (d)
make all other  material  decisions  relating to the operation of the Plan.  The
Committee  may  adopt  such  rules  or  guidelines  as it deems  appropriate  to
implement the Plan.

STOCK OPTIONS

         As of April 1, 1999,  the closing price for Cytogen Common Stock on the
Nasdaq National Market was $1.00

         On the date of the 1999 annual meeting of shareholders, each individual
who is at that time serving as a Non-Employee  Director shall  automatically  be
granted a Stock Option to purchase  21,000 Shares of Cytogen common stock,  at a
price  equal to two times the market  price (the  "Initial  Grant").  On the day
following each Cytogen Corporation annual meeting of shareholders  following the
1999 Annual Meeting,  beginning with and including the meeting in the year 2000,
each  individual who is elected or re-elected as a  Non-Employee  Director shall
automatically  be granted a Stock  Option to purchase  10,000  Shares of Cytogen
common  stock.  Each  Non-Employee  Director  appointed  other than at an annual
meeting, following approval of the Director Option Plan, will receive an initial
grant, on the date of appointment,  equal to a pro rata portion of 10,000 shares
of Cytogen common stock, based upon the number of months remaining from the date
of election until the one year anniversary of the preceding  annual meeting.  In
addition,  the Chairman of the Board, unless the Committee determines otherwise,
will receive an additional grant of 15,000 shares of Cytogen Common Stock on the
date of each annual meeting.

         Other  than the  Initial  Grant,  which is  priced  at a  premium,  the
exercise  price of Options  under the Plan will equal the Fair Market Value of a
Share for the date of Grant,  which is defined in the  Directors  Option Plan as
the  average  of the high and low daily  sales  prices of a Share on the  Nasdaq
National Market for that day or, if there are no sales on such day, for the most
recent prior day on which a Share was sold on the Nasdaq National Market.

                                       7

<PAGE>


         Each grant of a Stock Option  shall be evidenced by an agreement  which
shall reflect the terms and conditions of the Stock Options and such  additional
terms and  conditions as are  determined by the  Committee.  Upon exercise of an
Option, the option holder must make payment of the exercise price to the Company
in cash.

TERMS  AND CONDITIONS  OF STOCK  OPTIONS

         The Initial Grant will vest and become  exercisable in equal  one-third
increments  at the first,  second,  and third  anniversaries  of the Grant Date.
Otherwise,  Stock Options  become  exercisable  on the first  anniversary of the
Grant  Date.  However,  in the  event  that  prior to the  vesting  date (A) the
Non-Employee  Director  terminates  his service on the Board by reason of death,
disability or retirement, or (B) the Company is merged, or other parties seek to
acquire or acquire  ownership  of greater  than fifty  percent of the  Company's
stock,  then a Stock  Option  shall  become  immediately  exercisable  upon  the
occurrence  of such events.  Subject to the  foregoing,  a Stock Option shall be
exercisable  at any time in whole or in part on any  business day of the Company
before the date such Stock  Option  expires as outlined  below.  A Stock  Option
shall  expire on the first date on or after the Grant Date and prior to a Change
in Control on which the Non-Employee  Director resigns from or is not re-elected
to the Board prior to being eligible for  retirement.  A Stock Option shall also
expire on the date the Stock Option has been exercised in full. Furthermore, the
Stock  Option shall expire one day after the  expiration  of the 10-year  period
which  begins on the Grant Date or, in the case of a  Non-Employee  Director who
dies or becomes  disabled,  the last day of the one year period  which begins on
the date of the Non-Employee Director's death or disability.

TRANSFERABILITY DURING LIFETIME

         During the lifetime of a Non-Employee  Director,  only the Non-Employee
Director,  or his or her legal  representative,  may exercise a Stock Option. No
Stock  Option  may be  sold,  assigned,  transferred,  exchanged,  or  otherwise
encumbered  or  made  subject  to any  creditor's  process,  whether  voluntary,
involuntary or by operation of law.

ADJUSTMENTS

         In the event that there is any change in the  Cytogen  common  stock by
reason of any  dividend  or other  distribution,  recapitalization,  forward  or
reverse split, reorganization,  merger,  consolidation,  spin-off,  combination,
share exchange, or other similar corporate transaction or events, the number and
kind of Shares  which may be  delivered,  the Exercise  Price or purchase  price
relating to any Stock Option may be  appropriately  adjusted by the Committee at
the time of such event on a proportionate basis.

AMENDMENTS

         The Board of Directors shall have the right to amend,  modify,  suspend
or terminate  the  Directors  Option Plan at any time for any purpose;  provided
that   following  the  approval  of  the   Directors   Option  Plan  by  Cytogen
shareholders, the Director Stock Plan may not be amended in a manner which would
disqualify the Directors  Option Plan from the exemption  provided by Rule 16b-3
under the Exchange Act or from  qualification for deduction by the Company under
Section 162(m).

FEDERAL INCOME TAX CONSEQUENCES

         The rules  governing the tax treatment of Stock Options are  technical.
Therefore,  the  description  of the Federal income tax  consequences  set forth
below is  necessarily  general  in nature and does not  purport to be  complete.
Moreover,   statutory   provisions   are   subject  to  change,   as  are  their
interpretations,  and their  applications may vary in individual  circumstances.
Finally,  the tax consequences  under applicable state and local income tax laws
may not be the same as under the Federal income tax laws.

STOCK OPTIONS

         The  Stock  Options  granted  under  the  Director  Stock  Plan will be
non-qualified stock options ("NQSOs").  The Non-Employee  Director recognizes no
taxable income at the time of grant.  Upon exercise of an NQSO, the Non-Employee
Director  recognizes  ordinary income and the Company receives a deduction equal
to the  difference  between the exercise  price and the fair market value of the
Shares  on the date of  exercise.  The  Non-Employee  Director  recognizes  as a
capital  gain or loss any  subsequent  profit  or loss  realized  on the sale or
exchange of any shares disposed of or sold.

                                       8
<PAGE>

         The  Non-Employee  Directors listed on the following table are expected
to receive in 1999 under the Directors Option Plan grants of the number of Stock
Options shown on the table.

                     NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN

                                                       STOCK
                  DIRECTOR                            OPTIONS*
                  --------                            --------

                  James A. Grigsby                     36,000

                  John E. Bagalay, Jr.                 21,000

                  Ronald J. Brenner                    21,000

                  Stephen K. Carter                    21,000

                  Robert F. Hendrickson                21,000

*No dollar value is assigned to the Stock Options  because their  exercise price
will be dependent  upon the market value of the underlying  Cytogen  Corporation
common stock on the date of grant.

      THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL TWO


                                       9

<PAGE>


                             EXECUTIVE COMPENSATION

    The following table sets forth the annual and long-term compensation awarded
to, earned by or paid to (i) the Company's Chief Executive Officer(s),  and (ii)
the other four most highly compensated  executive  officers of the Company,  for
services  rendered  to the  Company  during the  Company's  fiscal  years  ended
December 31, 1998, 1997 and 1996.
<TABLE>
<CAPTION>

                                                       SUMMARY COMPENSATION TABLE

                                          ANNUAL                                            LONG-TERM
                                      COMPENSATION (1)                                     COMPENSATION
                                      ----------------                                     ------------
                                                                        OTHER        RESTRICTED   SECURITIES
                                                                        ANNUAL         STOCK      UNDERLYING        ALL OTHER
                                    FISCAL     SALARY       BONUS       COMPEN-        AWARD       OPTIONS       COMPENSATION(2)
NAME AND PRINCIPAL POSITION          YEAR       ($)          ($)        SATION ($)      ($)           (#)              ($)         
- ---------------------------        -------    --------    ---------    -----------   ----------  ------------    ---------------


<S>                                  <C>       <C>        <C>               <C>           <C>      <C>                  <C>
H. Joseph Reiser (3)                 1998      89,903     150,000           0             0        2,250,000            399
     President and Chief
     Executive Officer

John E. Bagalay, Jr. (5)             1998     183,321           0           0             0          110,000            838
     President and Chief
     Executive Officer

Thomas J. McKearn (6)                1998     298,012           0           0             0          200,000          5,016
     Chairman, President and Chief   1997     298,012           0           0             0                0(8)      10,613
     Executive Officer               1996     284,181      49,150           0             0(7)       155,000(8)      10,650

Graham May (10)                      1998     226,270      10,000           0             0          203,743          7,674
     Vice President, Medical         1997     206,446      31,100           0             0           45,000          6,515
     Affairs and Corporate
     Development
  
Robert J. Broeze (11)                1998     169,384      50,000           0             0          150,000          6,387
     Vice President,                 1997     159,794      27,300           0             0           15,000          6,241
     Operations

John D. Rodwell                      1998     203,000           0           0             0          150,000          8,881
     Senior Vice President           1997     202,999      22,800           0             0                0          8,631
     and Chief Scientific            1996     187,198      35,150           0             0           82,000          8,499
     Officer

Donald F. Crane, Jr. (12)            1998     188,308      12,500           0             0          181,763          3,484
     Vice President,                 1997      93,462      30,375           0             0           55,000            374
     General Counsel
     and Corporate Secretary
</TABLE>
- ---------------------


(1) Perquisites or personal benefits did not exceed the lesser of either $50,000
    or 10% of total  annual  salary  and  bonus  reported  for the  named  
    executive officers.

(2) The amounts disclosed in this column include amounts contributed or accrued
    by the Company in the respective  fiscal years under the Company's  Savings
    Plan, a defined  contribution plan which consists of a 401(k) portion and a
    discretionary contribution portion. In fiscal year 1998, these amounts were
    as follows:  on behalf of Dr. Reiser,  $0; Dr.  Bagalay,  $0; Dr.  McKearn,
    $3,977; Dr. May, $6,706; Dr. Broeze,  $5,969; Dr. Rodwell,  $8,000; and Mr.
    Crane,  $3,000.  The amounts disclosed also include insurance premiums paid
    by the Company with respect to group term life  insurance  and with respect
    to fiscal  year 1998,  these  amounts  were as  follows:  on behalf of; Dr.
    Reiser $399; Dr.  Bagalay,  838; Dr.  McKearn,  $1,039;  Dr. May, $968; Dr.
    Broeze, $418; Dr. Rodwell, $881; and Mr. Crane, $484.

                                       10
<PAGE>

(3)  Dr.  Reiser  joined the Company as  President  and Chief  Executive Officer
     effective August 24, 1998.

(4)   Pursuant to Dr. Reiser's Employment Agreement,  the Company granted to Dr.
      Reiser an option to purchase up to 2,250,000  shares of Common Stock at an
      exercise price of $1.0937,  vesting 33.3% annually.  The vesting  schedule
      begins as follows:  (a)  900,000  shares  begin  vesting  upon  commencing
      employment;  (b) 450,000  shares begin vesting upon  completion of certain
      performance objectives, to the satisfaction of the Board of Directors; (c)
      450,000 shares begin vesting upon the completion of additional performance
      objectives  to the  satisfaction  of the Board of  Directors;  (d) 450,000
      shares begin vesting upon the achievement of the Company's profitability.

(5)   Dr. Bagalay served as interim  President and Chief Executive  Officer from
      January 1998, following Dr. McKearn's resignation,  until August 1998 when
      Dr. Reiser assumed these positions.

(6)  Dr. McKearn resigned from the Company during September, 1998.

(7)  On December 8, 1994,  Dr.  McKearn  and the  Company  entered  into a Stock
     Compensation   and   Performance   Option   Agreement  (the   "Compensation
     Agreement"),  which  provided  for the  issuance  to Dr.  McKearn of 30,000
     shares of Common Stock in three  installments  of 10,000  shares in each of
     1994,  1995 and 1996. On December 8, 1994, Dr.  McKearn  received the first
     installment  of 10,000  shares upon payment made equal to the aggregate par
     value of the shares.  On January 3, 1995, Dr.  McKearn  received the second
     installment  of 10,000  shares upon payment made equal to the aggregate par
     value of the shares.  On January 3, 1996,  Dr.  McKearn  received the third
     installment  of 10,000  shares upon payment made equal to the aggregate par
     value of the shares.

(8)  Pursuant to the Compensation Agreement, the Company granted to Dr. McKearn,
     effective as of January 3, 1994, an option to purchase up to 100,000 shares
     of Common  Stock at an  exercise  price of  approximately  $6.188 per share
     (subject to adjustment under certain circumstances). Vesting of this option
     is at the  discretion  of  the  Compensation  Committee  of  the  Board  of
     Directors.  Any shares not vested were irrevocably  canceled and ineligible
     for future  vesting under the grant.  In December  1995,  the  Compensation
     Committee considered the vesting of the second installment of 20,000 shares
     and  determined  that  15,000  shares  should  vest.  In  March  1997,  the
     Compensation  Committee  considered the vesting of the third installment of
     20,000  shares  and   determined   that  17,000  shares  should  vest.  See
     "Employment  and  Severance   Arrangements".   Pursuant  to  Dr.  McKearn's
     resignation,  there  will  be no  further  vesting  of  shares  under  this
     Agreement.

(9)  In 1995, the Company and Dr. McKearn entered into a Split Dollar Collateral
     Assignment Agreement. Under this agreement, the Company was responsible for
     the payment of all premiums due for two life insurance policies on the life
     of Dr.  McKearn,  having a total  face  value of $2.3  million.  The amount
     disclosed in the Summary Compensation Table reflects the $2,000 in value of
     the premiums paid by the Company under these  insurance  policies in fiscal
     year 1998,  prior to Dr.  McKearn's  resignation,  that was attributable to
     term  life  insurance   coverage.   However,   pursuant  to  Dr.  McKearn's
     resignation,  both policies were surrendered by the Company in exchange for
     the amount of premiums paid by the Company over the lives of each policy.

(10)  Dr. May joined the Company as Vice President,  Medical Affairs,  effective
      January 2, 1997.  He assumed  additional  responsibilities  for  Corporate
      Development in January 1998.

(11)  Dr. Broeze was elected Vice President of Operations in February,  1997. He
      resigned from the Company in January,  1999, to accept a position with the
      purchaser of the Company's manufacturing facilities.

(12)  Mr. Crane  joined  the  Company as Vice  President,  General  Counsel  and
      Corporate Secretary effective June 16, 1997. 

                                       11

<PAGE>


     The following table sets forth information  regarding  individual grants of
stock options to the named executive officers during fiscal year 1998:
<TABLE>
<CAPTION>

                                                 OPTION GRANTS IN FISCAL YEAR 1998
                                                                                      POTENTIAL REALIZABLE VALUE AT ASSUMED ANNUAL
                                                                                      RATES OF STOCK PRICE APPRECIATION FOR OPTION
                                                INDIVIDUAL GRANTS                                          TERM (3)
                           ---------------------------------------------------------   -------------------------------------------
                                                 
                                             PERCENT OF
                             NUMBER OF         TOTAL
                            SECURITIES        OPTIONS     
                            UNDERLYING       GRANTED TO     EXERCISE OR
                              OPTIONS       EMPLOYEES IN     BASE PRICE    EXPIRATION
     NAME                     GRANTED        FISCAL YEAR   (PER SHARE)(2)     DATE             5%($)             10%($)
     ----                   ----------      ------------   --------------  ----------        ---------        ----------
<S>                        <C>                  <C>            <C>          <C>              <C>              <C>      
H. Joseph Reiser           2,250,000 (1)        50.03          1.097         8/18/08         1,552,269        3,933,755


John E. Bagalay, Jr.         100,000 (1)         2.22          1.953         1/20/08           122,823          311,258
                              10,000 (4)          .22           .812        10/15/08             5,110           12,949
                                

Thomas J. McKearn            200,000 (5)         4.45          1.953         9/18/01           245,646          622,516
                             

Graham S. May                150,000 (5)         3.34          1.953         1/20/08           184,235          466,887
                              41,666 (4)          .93          1.050         8/26/08            27,514           69,725
                              12,077 (4)          .27           .828        12/28/08             6,289           15,937
            
Robert J. Broeze             150,000 (5)         3.34          1.953         1/20/08           184,235          466,887

John D. Rodwell              150,000 (5)         3.34          1.953         1/20/08           184,235          466,887

Donald F. Crane, Jr.         125,000 (5)         2.78          1.953         1/20/08           153,529          389,072
                              41,666 (4)          .93          1.050         8/26/08            27,514           69,725
                              15,097 (4)          .34           .828        12/28/08             7,861           19,222

</TABLE>
- -----------------------

(1) Pursuant to Dr. Reiser's  Employment  Agreement,  the Company granted to Dr.
Reiser  an option  to  purchase  up to  2,250,000  shares of Common  Stock at an
exercise price of $1.0937,  vesting 33.3% annually.  The vesting schedule begins
as follows:  (a) 900,000 shares begin vesting upon  commencing  employment;  (b)
450,000 shares begin vesting upon completion of certain performance  objectives,
to the satisfaction of the Board of Directors;  (c) 450,000 shares begin vesting
upon the completion of additional  performance objectives to the satisfaction of
the Board of Directors; (d) 450,000 shares begin vesting upon the achievement of
the Company's profitability.

(2) The exercise price of all stock options  granted during the last fiscal year
is equal to the average of the high and low sale  prices of the Common  Stock as
reported on the Nasdaq National Market on the respective  dates the options were
granted.

(3) These amounts represent  certain assumed rates of appreciation  only. Actual
gains, if any, on stock option exercises and Common Stock holdings are dependent
on  the  future  performance  of the  Common  Stock  and  overall  stock  market
conditions. There is no assurance that the amounts reflected will be realized.

(4) These options were fully vested at the date of grant.

(5) Options vest over three years at the rate of 33.3% per year beginning on the
first  anniversary of the date of grant,  subject to acceleration  under certain
conditions. The maximum term of each option granted is 10 years from the date of
grant.

                                       12
<PAGE>

     The following table sets forth information  regarding  aggregated exercises
of stock  options by the named  executive  officers  during fiscal year 1998 and
fiscal year-end values of unexercised options:
<TABLE>
<CAPTION>


                                                AGGREGATED OPTION EXERCISES IN LAST
                                           FISCAL YEAR AND FISCAL YEAR-END OPTION VALUES

                                                                             NUMBER OF SECURITIES       VALUE OF UNEXERCISED
                                                                            UNDERLYING UNEXERCISED    IN-THE-MONEY OPTIONS AT
                                                                               OPTIONS AT FY-END            FY-END(1)(2)
                                                                            ----------------------    -----------------------
                                                                                      (#)                        ($)
         NAME                     SHARES ACQUIRED       VALUE REALIZED           EXERCISABLE/                EXERCISABLE/
         ----                      ON EXERCISE(#)           ($)(1)               UNEXERCISABLE              UNEXERCISABLE
                                  --------------        -------------            -------------              -------------
<S>                                      <C>                  <C>              <C>                               <C>
H. Joseph Reiser                         0                    0                350,000/1,900,000                 0/0
John E. Bagalay, Jr.                     0                    0                 18,400/111,600                   0/0
Thomas J. McKearn                        0                    0                    363,000/0                     0/0
Graham S. May                            0                    0                 62,743/186,000                   0/0
Robert J. Broeze                         0                    0                 46,000/175,200                   0/0
John D. Rodwell                          0                    0                 204,300/247,200                  0/0
Donald F. Crane, Jr.                     0                    0                 67,763/169,000                   0/0
</TABLE>

- ------------------------


(1)  The  dollar  values in this  column  were  calculated  by  determining  the
     difference between the fair market value of the Common Stock underlying the
     options at fiscal year-end or the date of exercise, as the case may be, and
     the exercise price of the options.

(2)  The fair market  value of a share of Common  Stock  (calculated  as the 
     average of the high and low sale prices as reported on the Nasdaq National 
     Market) on December 31, 1998 was $.828.



                                       13

<PAGE>



         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

This report and the  Performance  Graph  contained in this Proxy Statement shall
not be deemed  incorporated by reference into any of the Company's filings under
the Securities Act of 1933, as amended,  or the Securities Exchange Act of 1934,
as amended.

POLICY

    The  Compensation  Committee of the Board of Directors (the  "Committee") is
responsible for oversight of the Company's executive  compensation  program. The
Committee  is composed  entirely of  independent,  non-employee  directors.  The
Committee makes  recommendations  to the full Board of Directors on compensation
policy and as to specific compensation actions,  except where independent action
by the Committee is appropriate.

    The Company's  compensation program, both for its executive officers as well
as for all  employees,  is based on the  philosophy  that the  interests  of the
employees  should be closely  aligned with those of the Company's  stockholders.
The 1998 executive compensation program was based on the following principles:

    - compensation  opportunities should attract the best talent to the Company;
motivate  individuals  to perform at their highest  levels;  reward  outstanding
achievement;  and  retain  the  leadership  and skills  necessary  for  building
long-term stockholder value;

    - a portion of total compensation should be at risk of performance; and

    - individual  executives should be encouraged to manage from the perspective
of owners of the Company.

    The Company's 1998 compensation program reflected the Committee's assessment
as to appropriate  treatment on an individual basis for the named executives and
the former  Chief  Executive  Officer  compared to the prior year  levels.  1997
compensation was generally benchmarked by a 1996 compensation study conducted by
an  independent  compensation  consultant,   including  a  survey  of  companies
representative of the firms with which the Company competes for employee talent.
The  comparative  companies  included,  but were not identical to, the companies
included in the peer group with respect to the stock  performance  graph set out
below. The Company targets its overall  compensation program at the median level
of the  biotechnology  industry.  In addition,  compensation  for the named (and
other) executives,  including the Chief Executive Officer(s),  took into account
individual responsibility and performance as assessed by the Committee.

    The  compensation  program includes a combination of competitive base salary
and benefits, annual cash bonus opportunities, and stock option awards. The 1998
executive  compensation program and a specific discussion as to the compensation
of the Chief Executive Officer are set out below.

ANNUAL COMPENSATION FOR 1998

    Generally,  annual  compensation  of executive  officers under the executive
compensation program for 1998 consisted of salary and bonus components.

BASE SALARY

    In December 1997, the Compensation  Committee  determined for recommendation
to the full Board base salaries and annual incentive  opportunities for 1998 for
its executives,  including the named executives and Dr. Thomas McKearn,  who was
then serving as the Company's Chief Executive Officer. The base salaries for Dr.
Reiser and Dr. Bagalay were set at the time of their election to office.

BONUS

    A portion of 1998 executive  officer  annual  compensation  opportunity  was
based on corporate  and  individual  performance.  The  Committee  believes that
incentive   compensation  should  be  linked  to  corporate  financial  results,
particularly  as the Company  commercializes  its products.  The Committee  also
believes  that,  while  performance  goals should  include  corporate  financial

                                       14

<PAGE>
results,  executives  should also be held accountable for their individual areas
of  responsibility.  Bonus  opportunity  levels for 1998 performance were set in
advance of the year at a percentage of base salary, with the total amount of the
bonus  opportunity  dependent on the extent to which  individual  and  corporate
objectives  were achieved and the amount of cash  available as determined by the
Committee.  At  year-end,  the  Committee  reviewed  the  extent  to  which  the
objectives  have been  achieved.  The Committee  believed  that,  despite severe
difficulties  faced by the  Company  during  1998,  bonuses  of some  level were
important,  in  recognition  of  perseverance  by  the  named  executives  under
difficult  circumstances and for achievement of significant corporate objectives
related to a turnaround of the Company during the year. The amounts  approved on
the Committee's  recommendations were less than target amounts; in addition, the
Company  paid a portion of the awards by an  additional  year-end  stock  option
grant to certain of the named executives.

LONG TERM COMPENSATION - STOCK OPTIONS

    The  Compensation  Committee  believes that stock options are an appropriate
means to link its employees' interest with those of the Company's  stockholders.
Stock option  awards are designed  primarily to provide  strong  incentives  for
superior longer-term performance and continued retention by the Company. Because
it is  believed  that  corporate  performance  is one of the  principal  factors
influencing  the market value of the  Company's  Common  Stock,  the granting of
stock  options  to  executive  officers  encourages  them  to  work  to  achieve
consistent improvements in corporate performance. Options only have value to the
executive  when the price of the  Company's  common  stock  exceeds the exercise
price,  which is not less than the fair market  value of the common stock at the
date of grant.

    Stock option  grants were made to the named  executive  officers in 1998, as
follows:  Dr. McKearn,  200,000;.  Dr. May, 150,000;  Dr. Rodwell,  150,000, Dr.
Broeze,  150,000,  and Mr. Crane,  125,000.  These option grants were set taking
into  account the  comparison  of  practices at peer groups (in the survey noted
above),  an individual's  level of  responsibility  and furtherance of corporate
objectives,  and the amount and terms of past stock option awards. The Committee
believes that retention of key  executives is critical to the Company's  success
during its period of  transition.  The  Committee  also took into account in its
review  of  option  grants  the fact  that the  Company  has no other  long term
incentive program,  and believes that options are important to retain executives
and promote steps to build long term value. Additionally,  further option grants
were made to Dr. May and Mr.  Crane in August,  1999,  in  recognition  of their
serving on a committee of management  related to planning and  implementation of
the Company's  turnaround  plan.  Finally,  option grants were made in December,
1998, to the named executive officers, as disclosed,  as payment of bonus awards
deemed  appropriate for these  individuals  for  performance  during the year in
furthering the restructuring of the Company.

COMPENSATION OF THE CHIEF EXECUTIVE OFFICER

    Dr.  Reiser's  salary for 1998 was set by agreement  between the Company and
Dr.  Reiser  in  advance  of his  employment  by the  Company.  The  amount  was
determined on the  recommendation of the Committee to be an appropriate level of
base compensation in view of compensation  levels paid by the industry,  in view
of Dr. Reiser's  experience,  and considering the significant  challenges facing
the Company.  The bonuses paid Dr.  Reiser for 1998  performance  reflected  the
extraordinary  accomplishments of the Company under his leadership following his
joining the Company in the latter half of the year. The total amount  includes a
bonus in the  amount of  $50,000  paid as a sign-on  bonus  concurrent  with his
acceptance of employment,  and a year end bonus in the amount of $100,000.  This
latter  amount  was  based on the  Committee's  judgment  as to the value of his
leadership to the Company during a critical period.

    Dr.  Bagalay's  salary was set on the  Committee's  recommendation  upon his
agreeing to assume the interim responsibility as Chief Executive Officer pending
the  recruitment of a new Chief Executive  Officer.  The amount was not based on
comparability  studies,  but on the  Committee's  judgment as to the appropriate
level  of  compensation,   given  Dr.  Bagalay's  experience  and  his  personal
commitment to the Company in a difficult  period.  Dr. Bagalay  received no cash
bonus for his efforts,  however,  part of his  compensation  included a grant of
options as disclosed above.


                                       15

<PAGE>


    Dr. McKearn received no increase in base  compensation  during 1998 over his
prior year salary,  and received no bonus for 1998  performance.  The  Committee
recommended,  and the full Board  determined,  that it would be  appropriate  to
maintain his salary at 1997 levels for the period in which he remained  employed
by the Company.

TAX CONSIDERATIONS

        Federal tax laws impose a limit on deductions for each of the executives
named in the summary  compensation  table to $1 million.  Certain  compensation,
including  compensation  based on  performance,  is not subject to this limit if
certain  conditions  are  met,  primarily,  that  the  compensation  is based on
objective  performance  criteria approved by the stockholders.  The Compensation
payments  must also be made  pursuant to a plan  administered  by a committee of
outside  directors.  The Committee must certify that the performance  goals were
achieved before payments can be awarded.

    The Committee believes that its executive compensation program is consistent
with the intent of this  legislation.  The  Company's  stock  option plans under
which  options may be granted to  executive  officers  has been  approved by the
stockholders  and qualifies for the exclusion  from the deduction  limits.  Base
salary,  annual bonuses, and certain other compensation amounts disclosed in the
summary  compensation table do not qualify for the exclusion from the $1 million
limit but such amounts of compensation  are not expected to exceed the deduction
limits. The Committee will consider  appropriate steps in the future,  including
stockholder  approval,  to maintain  deductions  for its incentive  compensation
plans to the greatest  extent  practical while  maintaining  flexibility to take
actions which it deems in the best interests of the Company and its stockholders
but which may result in certain compensation not qualifying for tax deductions.

  The Committee believes that performance should be rewarded, that the financial
interests of the executive officers should be aligned with the stockholders, and
that compensation should be competitive.  We have structured compensation at the
Company to meet these criteria.


                                   * * * * *

The  foregoing  report on  compensation  is  provided by the  following  outside
directors, who constituted the Compensation Committee during 1998:


                                                     Ronald J. Brenner, Chairman
                                                     Robert F. Hendrickson



                                       16

<PAGE>


                                PERFORMANCE GRAPH

     The following  Performance  Graph compares the Company's  cumulative  total
stockholder return on the Common Stock for a five-year period (December 31, 1993
to December 31, 1998) with the cumulative total return of the Nasdaq U.S. Stocks
Index and the Nasdaq  Pharmaceutical  Index, a broad index of  biopharmaceutical
and  pharmaceutical  companies similar in capitalization  and stage of corporate
development to the Company.*



                           [LINE GRAPH APPEARS HERE]

<TABLE>
<CAPTION>

- ------------------------------------------------------------------------------------------------
                                1993       1994        1995        1996        1997        1998
- ------------------------------------------------------------------------------------------------
<S>                           <C>         <C>         <C>         <C>         <C>         <C>   
Cytogen Corporation           $100.00     $67.71      $87.50      $91.67      $27.08      $14.06
- ------------------------------------------------------------------------------------------------
NASDAQ U.S. Stocks Index      $100.00     $97.75     $138.26     $171.01     $208.58     $293.21
- ------------------------------------------------------------------------------------------------
NASDAQ Pharmaceutical Index   $100.00     $75.26     $138.04     $138.47     $142.98     $183.02
- ------------------------------------------------------------------------------------------------
</TABLE>



                                       17
<PAGE>


EMPLOYMENT AND SEVERANCE ARRANGEMENTS

     The Company  entered an employment  agreement  with the President and Chief
Executive  Officer,  H. Joseph  Reiser,  Ph.D.,  which  provides for bonuses and
vesting of options for the purchase of shares of common stock based on continued
employment and on the achievement of performance objectives defined by the Board
of Directors.  Dr. Reiser is also entitled to one year's  severance  pay,  along
with medical and insurance  benefits for the same period, if he is dismissed for
reasons other than cause.

     Under the terms of an  employment  agreement,  Dr.  Thomas J.  McKearn  was
entitled to one year's  severance pay if he was dismissed for reasons other than
for cause.  Pursuant  to that  agreement,  Dr.  McKearn's  base  salary is being
continued  for a  period  of one  year  from  the  date  of his  termination  of
employment in September, 1998.

     Under the terms of severance  agreements,  Drs. Rodwell, May and. Mr. Crane
will also be entitled  to receive  twelve  months of salary if their  employment
with the Company is terminated without cause.

GENERAL INFORMATION

            SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

 On the basis of reports and  representations  submitted  by or on behalf of the
directors,  executive officers and ten percent  stockholders of the Corporation,
all  Forms 3, 4 and 5  showing  ownership  of and  change  of  ownership  in the
Corporation's   equity  securities  during  1998  were  timely  filed  with  the
Securities and Exchange  Commission as required by Section 16(a) of the Exchange
Act  of  1934,  except  that  an  initial  Form  3  Report  by  Dr.  Carter  was
inadvertently filed several days late due to travel exigencies.

OTHER BUSINESS

          The Board of Directors  does not intend to present any business  other
than the matters described in this Proxy Statement at the Annual Meeting. If any
other matter is presented at the Annual  Meeting  which under  applicable  proxy
regulations  need not be included in this Proxy  Statement or which the Board of
Directors  did not know a  reasonable  time  before this  solicitation  would be
presented,  the  persons  named in the  accompanying  proxy  have  discretionary
authority to vote proxies with respect to such matter in  accordance  with their
best judgment.

                                       18

<PAGE>


EXPENSES OF SOLICITATION

          The expense of this proxy  solicitation  will be paid by the  Company.
Some of the  officers and regular  employees of the Company may solicit  proxies
personally  and by  telephone.  Management  may also  request  banks,  brokerage
houses,  custodians,  nominees and fiduciaries to obtain  authorization  for the
execution of proxies and may  reimburse  them for  expenses  incurred by them in
connection   therewith.   The   Company   plans   to  use   Corporate   Investor
Communications,  Inc., which will receive $4,000 plus certain expenses,  for any
proxy solicitation that may be necessary.

OTHER MATTERS

         The  persons  named  in the  enclosed  form of  proxy  have no  present
intention of bringing before the meeting for action any matters other than those
specifically referred to above, nor has management or the Board of Directors any
such intention,  and none of such persons,  management or the Board of Directors
is aware of any matters  which may be presented by others.  If any such business
should properly come before the meeting,  the persons named in the form of proxy
intend to vote thereon in accordance with their best judgment.

                          FUTURE STOCKHOLDER PROPOSALS

          The Company must receive at the Office of the Corporate  Secretary any
proposal  which a  stockholder  wishes to submit to the 2000  Annual  Meeting of
Stockholders before January 13, 2000, if the proposal is to be considered by the
Board of Directors for inclusion in the proxy material for that meeting.

                                             By Order of the Board of Directors
May 13, 1999


                                             Donald F. Crane, Jr.
                                             Corporate Secretary


                                       19

<PAGE>
                                    APPENDIX
                                    --------


CYTOGEN CORPORATION
1999 STOCK OPTION PLAN
FOR NON-EMPLOYEE DIRECTORS


1.       Purpose; Effective Date.

(a)  The  purposes  of  this  Plan  are to  further  the  interests  of  Cytogen
Corporation  (the "Company") by retaining the services of persons now serving as
non-employee Directors of the Company,  attracting and retaining the services of
persons  capable of serving on the Board of  Directors  of the  Company,  and by
providing  such persons with an incentive  that aligns their  interests with the
interests of the Company's shareholders.

(b) This Plan will become  effective on approval of the Plan by the  affirmative
vote of the majority of shares  present in person or  represented  by proxy at a
meeting of the shareholders of the Company and cast on the proposal for approval
of the Plan.

2.       Definitions.

Whenever used in this Plan, the following terms will have the meanings set forth
in this Section:

 "Board of Directors" means the Board of Directors of the Company.

 "Code" means the United States Internal Revenue Code of 1986, as amended.

"Common Stock" means the common stock, par value $.0l per share, of the Company.

"Date of Grant" means with respect to any Option the date the Option will become
effective under the provisions of this Plan.

"Disability" means inability of a Director to engage in any substantial  gainful
activity by reason of a  medically  determinable  physical or mental  impairment
which  reasonably  can be expected to last for a  continuous  period of not less
than six months.

"Eligible  Director"  means,  as of any time,  a person who is a director of the
Company but is not then an Employee.

"Employee"  means  any  person  employed  by  the  Company  (including,  without
limitation,  a person employed by the Company who is also an officer or director
of the Company).

"Exchange Act" means the Securities Exchange Act of 1934, as amended,  and rules
and regulations promulgated thereunder.

"Exercise Price" means with respect to any Option the price per share which must
be paid upon exercise of the Option.

<PAGE>

"Fair Market Value" means (i) if the Common Stock is traded in a market in which
actual  transactions  are  reported,  the  average of the high and low prices at
which the Common  Stock is reported to have traded on the  relevant  date in all
markets  on which  trading in the Common  Stock is  reported,  or if there is no
reported sale of the Common Stock on the relevant  date, the mean of the highest
reported bid price and lowest  reported  asked price for the Common Stock on the
relevant date,  (ii) if the Common Stock is Publicly  Traded but only in markets
in which there is no reporting of actual  transactions,  the mean of the highest
reported bid price and the lowest  reported  asked price for the Common Stock on
the relevant  date,  or (iii) if the Common Stock is not  Publicly  Traded,  the
value of a share  of  Common  Stock as  determined  by the  most  recent  annual
valuation  prepared  by an  independent  expert at the  request  of the Board of
Directors.

"Major  Event"  means when (i) the Company  enters  into one or more  definitive
agreements to merge or consolidate the Company with or into another corporation,
or to sell or otherwise  dispose of all or  substantially  all of the  Company's
assets,  or to effect any other  transaction,  consolidation  or  reorganization
having similar results or effect; (ii) any person other than the Company makes a
tender or  exchange  offer for more than 50% of Common  Stock  pursuant to which
purchases  of any amount of Common Stock are made;  or (iii) stock  representing
more than 50% of the voting power of the Company is acquired by any person other
than the  Company  in any one or more  transactions  occurring  in any  24-month
period.

"Option" means any option granted under this Plan.

"Option Agreement" means an agreement,  in such form as may be determined by the
Board of Directors or the  Committee,  executed and  delivered by the Company to
the holder of any Option with respect to that option.

"Option Shares" means, with respect to any Option,  the maximum number of shares
of Common Stock which may be acquired under the option prior to its expiration.

"Plan" means the Cytogen Corporation 1999 Directors Stock Option Plan.

 "Publicly  Traded" means, with respect to any class of stock, that the class of
stock is required to be registered  under Section 12 of the Securities  Exchange
Act of 1934,  as  amended,  or that stock of that class has been sold within the
preceding 12 months in an underwritten public offering.

"Termination  of  Service"  means the time when a Director  ceases to serve as a
Director for any reason,  including without limitation by reason of resignation,
retirement, removal, death or Disability.

3. Administration of the Plan.

(a) The Compensation Committee of the Board of Directors will be responsible for
the  administration  of this Plan.  The  Committee  shall consist of two or more
non-employee  directors  of the  Company  who meet the  definition  of  "outside
director"  under the provisions of Section 162(m) of the Code and the definition

                                       2

<PAGE>

of  "non-employee  director" under the provisions of the Exchange Act. No member
of the  Committee  shall have been within one year prior to  appointment  to, or
while  serving on, the  Committee  granted or awarded  equity  securities of the
Company  pursuant to this or any other plan of the Company  except to the extent
that  participation in any such plan or receipt of any such grant or award would
not adversely affect the Committee member's status as a "non-employee  director"
or as an "outside director".

(b) The Committee shall (i) determine or provide for the terms and conditions of
grant Agreements,  and all election and other forms,  which terms and conditions
shall not be inconsistent with this Plan, (ii) interpret the Plan and (iii) make
all other  decisions  relating to the  operation of the Plan.  The Committee may
adopt such rules or  guidelines as it deems  appropriate  to implement the Plan.
The Committee's  determinations under the Plan shall be final and binding on all
persons.

(c) No member  of the Board of  Directors  or of any  committee  of the Board of
Directors shall be liable for any act or omission of the Board or any committee,
or of any other member of the Board or any committee, or for any act or omission
on his own part, in connection  with the  administration  of this Plan unless it
resulted from the member's own willful misconduct.

4.       Persons Eligible to Receive options.

Options shall be granted only to Eligible Directors.

5.       Stock Subject to the Plan.

The maximum  number of shares of Common Stock as to which Options may be granted
under this Plan is 500,000 shares,  subject to adjustment as provided in Section
8. If any option expires or is cancelled, surrendered or forfeited without being
exercised in full,  the number of shares as to which the option is not exercised
will once again become shares as to which new Options may be granted. The Common
Stock  which is issued on exercise of Options  may be  authorized  but  unissued
shares or shares which have been issued and reacquired by the Company.

6.       Grants of Options.

(a)  The  grants  of  options   under   this  Plan   shall  be   automatic   and
non-discretionary.  Each Option shall be exercisable on the terms and subject to
the  conditions  specified in Section 7. No Option granted under this Plan shall
be an "incentive stock option" within the meaning of Section 422A of the Code.

(b) Effective on approval of the Plan by the shareholders, each person who is on
that date an Eligible Director shall be granted an Option to purchase twenty one
thousand (21,000) shares of Common Stock (the "Initial Option").

(c) Each person who is  appointed  a director  of the Company  after the date of
approval of the Plan by the Shareholders and is an Eligible  Director as of such
date shall be granted an Option to purchase a pro rata  portion of ten  thousand

                                       3

<PAGE>

(10,000) shares of Common Stock,  based upon the number of full months remaining
from the date of election until the one year anniversary  month of the preceding
annual meeting, as of the effective date of their appointment.

(d) On the day following each annual meeting of the stockholders of the Company,
commencing  with the 2000  annual  meeting,  each  person who is on that date an
Eligible  Director and was re-elected at that meeting shall be granted an Option
to purchase 10,000 shares of Common Stock. In addition,  a Chairman of the Board
of  Directors,  unless  the  Compensation  Committee  of  the  Board  determines
otherwise, shall receive an additional grant of fifteen thousand (15,000) shares
of Common Stock.

(e) Each Option  provided for in this  Section 6 shall be granted  automatically
and  without  further  action  by the  Company,  the Board of  Directors  or the
Company's stockholders. Promptly after the Date of Grant of each Option provided
for in this  Section  6, the  Company  shall  cause an  Option  Agreement  to be
executed  and  delivered  to the holder of the Option.  No other  Options may be
granted at any time under this Plan.

7.       Option Provisions.

(a) Exercise Price. The Exercise Price of the Initial Option will be 200% of the
Fair Market  Value of the Common  Stock on the Date of Grant of the Option.  The
Exercise  Price of each Option other than the Initial Option will be 100% of the
Fair Market Value of the Common Stock on the Date of Grant of the Option.

(b)      Term; Vesting.

(i) No Option  granted under this Plan may be exercised more than 10 years after
the Date of Grant of the option.

(ii) Except as provided in Sections 7(b)(iii),  7(f), 7(g) and 7(h), the Initial
Option shall become exercisable in one-third  increments  annually on the first,
second, and third anniversaries of the Date of Grant, and Options other than the
Initial Option shall become  exercisable in full on the first anniversary of the
Date of Grant.

(iii) Upon the occurrence of a Major Event,  all of the Option Shares covered by
an Option shall become  immediately  available for purchase upon exercise of the
option, without regard to the vesting provisions of Section 7(b)(ii).

(c)  Exercise of Options.  An Option may be exercised in whole or in part at any
time, or from time to time,  during its term. To exercise an Option,  the person
exercising the Option must deliver to the Company, at its principal office:

(i) a notice of  exercise of the  Option,  which  states the extent to which the
option is being exercised; and

                                       4

<PAGE>

(ii) payment in full in cash,  which may be  satisfied by a check,  in an amount
equal to the Exercise Price of the option times the number of shares as to which
it is being exercised.

(d) Delivery of Stock  Certificates.  As promptly as practicable after an option
is  exercised,  the Company will deliver to the person who exercises the Option,
certificates  registered in that person's name representing the number of shares
of Common  Stock  which were  purchased  by the  exercise  of the  option.  Each
certificate may bear a legend to indicate, if applicable,  that the Common Stock
represented  by the  certificate  was  issued  in a  transaction  which  was not
registered under the Securities Act of 1933, as amended, and may only be sold or
transferred  in a transaction  which is  registered  under that Act or is exempt
from the registration requirements of that Act.

(e)  Nontransferability  of Options.  During the lifetime of a person to whom an
option is issued,  the Option may be exercised only by that person or his or her
guardian  or legal  representative.  An Option may not be  assigned,  pledged or
hypothecated  in any way,  will not be  subject  to  execution,  and will not be
transferable otherwise than by will or the laws of descent and distribution. The
Company will not recognize any attempt to assign, transfer,  pledge, hypothecate
or otherwise  dispose of an option  contrary to the  provisions of this Plan, or
any levy of any attachment or similar  process upon any Option,  and,  except as
expressly  stated in this Plan,  the Company  will not be required  to, and will
not,  issue  Common  Stock on exercise of an option to anyone who claims to have
acquired that option from the person to whom it was granted.

(f)  Termination of Service of Director  Holding an Option Other Than Because of
Death or  Disability.  Subject to the  provisions  of Sections 7(b) and 7(h), if
there is a  Termination  of  Service  of a  director  to whom an Option has been
granted,  other  than by  reason  of the  director's  death  or  disability,  or
retirement,  each Option held by the director may be exercised until the earlier
of (x) the end of the  three-month  period  immediately  following  the  date of
Termination of service, or (y) the expiration of the term of the option.

(g) Death or  Disability  of  Director  Holding an Option.  Notwithstanding  the
provisions of Section  7(b), if there is a Termination  of Service of a director
to whom an  option  has  been  granted  by  reason  of the  director's  death or
disability,  or a former director dies within three months following the date of
his or her Termination of Service,  each option held by the Director on the date
of the  Director's  Termination  of Service may be exercised  in full (i.e.,  in
respect of up to 100% of the Option shares, regardless of the time elapsed since
the Date of  Grant)  until the  earlier  of (x) the end of the  one-year  period
immediately  following the date of  Termination of service or (y) the expiration
of the term of the option. In the event of an Eligible  Director's death, all of
such person's  outstanding Options will transfer to the maximum extent permitted
by law to such person's designated Beneficiary. Each Eligible Director may name,
from  time to  time,  any  beneficiary  or  beneficiaries  (which  may be  named
contingently  or  successively)  as his or her  Beneficiary for purposes of this
Plan. Each  designation  shall be on a form  prescribed by the Company,  will be
effective  only when delivered to the Company and when effective will revoke all
prior designations by the Eligible  Director.  If an Eligible Director dies with

                                       5
<PAGE>

no such  beneficiary  designation  in  effect,  such  person's  Options  will be
transferable  by will  or  pursuant  to the  laws of  descent  and  distribution
applicable to such person.

(h)  Retirement  or  Resignation.  If there is a  Termination  of  Service  of a
Director by reason of the Director's retirement or resignation at any time after
the  Director  has  reached age 55 with a minimum of three  years'  service as a
non-employee  director,  each  Option  held by the  Director  on the date of the
Director's  Termination of Service may be exercised in full (i.e., in respect of
up to 100% of the Option  Shares,  regardless of the time elapsed since the Date
of Grant)  until the earlier of (x) the end of the five year period  immediately
following the date of  Termination  of Service or (y) the expiration of the term
of the option.

8. Recapitalization, reorganizations, stock splits and the like.

(a) The existence of  outstanding  Options shall not affect in any way the right
or power of the  Company or its  stockholders  to make or  authorize  any or all
adjustments,   recapitalizations,   reorganizations  or  other  changes  in  the
Company's capital  structure or its business,  or any merger or consolidation of
the Company,  or any issue of bonds,  debentures,  preferred or prior preference
stock  ahead of or  affecting  the Common  Stock or the rights  thereof,  or the
dissolution or liquidation of the Company, or any sale or transfer of all or any
part of its assets or business or any other corporate act or proceeding, whether
of a similar character or otherwise.  Except as hereinafter  expressly provided,
the  issue  by the  Company  of  shares  of stock of any  class,  or  securities
convertible  into  shares of stock of any class,  for cash or  property,  or for
labor or services  either  upon  direct  sale or upon the  exercise of rights or
warrants to subscribe therefor, or on conversion of shares or obligations of the
Company convertible into such shares or other securities,  shall not affect, and
no adjustment by reason thereof shall be made with respect to, the number, class
or price of shares of Common Stock then subject to outstanding options.

(b) If as a result of any (i)  reorganization  or  liquidation of the Company or
(ii) reclassification of the Company's capital stock, stock splits, stock splits
in the form of dividends,  reverse stock splits, or similar recapitalizations of
the  Company,  or (iii)  consolidation  or  merger of the  Company  with or into
another  corporation,  or sale of all or  substantially  all the  assets  of the
Company (a reorganization or liquidation of the Company or  reclassification  of
the Company's  capital  stock,  or a merger,  consolidation  or sale of the type
described in this subsection being a "Corporate Transaction") while an Option is
outstanding,  the holders of the Common  Stock  become  entitled to receive with
respect to their Common  Stock,  securities or assets other than, or in addition
to, their  Common  Stock,  upon  exercise of that Option the holder will receive
what the  holder  would  have  owned if the  holder  had  exercised  the  Option
immediately  before the first  Corporate  Transaction  which  occurred while the
option was  outstanding  and had not  disposed of anything the holder would have
received as a result of that and all subsequent Corporate Transactions.


                                       6

<PAGE>

9.       Rights of Option Holder.

The holder of an Option will not have any rights as a  stockholder  by reason of
holding that Option.  Upon  exercise of an Option,  the holder will be deemed to
acquire the rights of a stockholder when, but not before, the issuance of Common
Stock as a result  of the  exercise  is  recorded  in the stock  records  of the
Company.

10.      Laws and Regulations.

The  obligation  of the  Company to sell and deliver  shares of Common  Stock on
exercise of options will be subject to the condition  that legal counsel for the
Company be satisfied  that the sale and delivery will not violate the Securities
Act of 1933, as amended, or any other applicable laws, rules or regulations.

11.      Reservation of Shares.

The Company will at all times keep  reserved for issuance on exercise of options
a number of authorized  but unissued or reacquired  shares of Common Stock equal
to the maximum number of shares the Company may be required to issue on exercise
of outstanding options (assuming no subsequent adjustments under Section 8).

12. Amendment of the Plan.

The Board of  Directors  may at any time and from  time to time  modify or amend
this  Plan  in any  respect  effective  at  any  date  the  Board  of  Directors
determines;  provided,  that  without the  approval of the  stockholders  of the
Company  the Board of  Directors  may not,  (i) except as provided in Section 8,
increase  the  maximum  number of shares of Common  Stock which may be issued on
exercise  of Options  granted  under this Plan;  (ii) change the  provisions  of
Section 6 or Section  7; (iii)  change the  categories  of persons  eligible  to
receive options under this Plan; or (iv) otherwise  materially  increase (within
the meaning of Rule 16b-3 of the Exchange Act) the benefits  accruing under this
Plan. No modification or amendment of this Plan will, without the consent of the
holder of an outstanding Option, adversely affect the holder's rights under that
Option.  Notwithstanding approval by shareholders, the Board may amend this Plan
without further  shareholder  approval to add provisions  required or enabled by
changes to Rule 16b-3.

13. Termination of the Plan.

This Plan will terminate on June 16, 2008, unless sooner  terminated.  The Board
of  Directors  may  suspend or  terminate  this Plan at any time or from time to
time, but no such action may adversely  affect the rights of a person holding an
outstanding  Option.  The  applicable  terms  of the  Plan,  and any  terms  and
conditions as applicable  to Options  granted prior to such date,  shall survive
the termination of the Plan and continue to apply to such Options.

                                       7

<PAGE>

                                   PROXY CARD
                                   ----------

                               CYTOGEN CORPORATION

                                      PROXY
                       SOLICITED BY THE BOARD OF DIRECTORS

     H. Joseph  Reiser,  and Donald F. Crane,  Jr., and each of them,  with full
power of  substitution,  are hereby  appointed the Proxies of, and authorized to
represent,  the  undersigned  and to vote all of the  shares of Common  Stock of
CYTOGEN CORPORATION entitled to be voted by the undersigned as of April 23, 1999
as directed on the reverse side and, in their  discretion,  on all other matters
which may properly come before the Annual Meeting of  Stockholders to be held on
June 16, 1999, and at any adjournment  therof as if the undersigned were present
and voting at the meeting.

     Wherther or not you expect to attend the meeting,  you are urged to execute
and return this proxy, which you may revoke at any time prior to its use.

     The  shares  represented  by this proxy  will be voted as  directed  by the
stockholders.  Where no  direction  is given  when  the duly  executed  proxy is
returned, such shares will be voted FOR all items. 

                 TO BE VOTED, YOU MUST SIGN ON THE REVERSE SIDE
                         (CONTINUED ON THE REVERSE SIDE)


<PAGE>
                                                            Please mark
                                                            your votes as 
                                                            indicated in  [ X ]
                                                            this example

The Board of Directors recommends a Vote FOR all items.

1.  Election of directors duly nominated:    Nominees: John E. Bagalay, Jr., 
                                                       Ronald J. Brenner, 
                                                       Stephen K. Carter,    
                                                       James A. Grigsby, 
                                                       Robert F. Hendrickson and
                                                       H. Joseph Reiser
         FOR        WITHHELD 
         [  ]         [  ]             To withold authority to vote for any 
                                       individual nominees write such nominee's 
                                       name in the space provided below.)

                                       -----------------------------------------

2.  To approve the 1999 CYTOGEN             3.  To transact such other business
    Non-Employee Director Stock                 as may properly come before the 
    Option Plan before the meeting.             meeting. 

    FOR      WITHHELD    ABSTAIN
    [  ]       [  ]        [  ]





                                         DATED:                             1999
                                                 --------------------------,

                                         ---------------------------------------
                                               (SIGNATURE(S) OF STOCKHOLDER(S)

                                         ---------------------------------------
                                               (SIGNATURE(S) OF STOCKHOLDER(S)

                                         NOTE:  The signature(s) should appear 
                                         the same as it appears on the address 
                                         label on this proxy.  When signing as 
                                         executor, administrator, trustee, 
                                         guardian, or attorney, please give full
                                         title as such.  For joint accounts or 
                                         co-fiduciaries, all joint owners or co-
                                         fiduciaries, should sign.
                                         THIS PROXY IS SOLICITED ON BEHALF OF 
                                         THE BOARD OF DIRECTORS

<PAGE>

FROM NORTHERN N.J.
Take the NJ Turnpike South to Exit 9. Follow Rt. 18 North approximately 1/2 mile
to Route 1 South.  Stay on Route 1 South  approximately  20 minutes to Princeton
Holiday Inn.

FROM PHILADELPHIA AREA
Take I-95 North until becomes I-295. Take Exit 67 (Rt. 1 North).  Follow Route 1
North  approximately  7 miles.  Take the Ridge Road jug handle across Route 1 to
Princeton Holiday Inn.

HIGHTSTOWN AREA
Take 571 West (Princeton-Hightstown Road) to Route 1 North. Follow Route 1 North
approximately  3  miles.  Take  the  Ridge  Road jug  handle  across  Route 1 to
Princeton Holiday Inn.

FROM ATLANTIC CITY AREA
Take the Garden State Parkway, North to Exit 98 (Route I-195 West). Follow I-195
West until it becomes I-295. Follow I-295 to Exit 67A (Route 1 North, New York).
Follow  Route 1 North  approximately  7 miles.  Take the Ridge  Road jug  handle
across Route 1 to Princeton Holiday Inn.

                             Princeton Holiday Inn
                            4355 Rt. 1 & Ridge Road
                              Princeton, NJ 08540
                                 (609)452-2400
                               (609)452-2494 Fax


                       [MAP TO HOLIDAY INN APPEARS HERE]





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