CYTOGEN CORP
SC 13D/A, 1999-01-19
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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SECURITIES AND EXCHANGE COMMISSION
Washington D.C.  20549

SCHEDULE 13D
Amendment No. 1


Under the Securities Exchange Act of 1934


CYTOGEN CORPORATION
(Name of Issuer)


Common Stock, $.01 par value
(Title of Class of Securities)


232824102
(CUSIP Number)


H. Vaughan Blaxter, III
1900 Grant Building
Pittsburgh, Pennsylvania 15219

(412) 281-2620
(Name, address and telephone number of person
authorized to receive notices and communications)

January 6, 1999
Date of Event which Requires Filing of this Statement


If the filing person has previously filed a statement on Schedule 13G to 
report the acquisition which is the subject of this statement, and is filing 
this statement because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the 
following:                                   [   ]






Page 1
<PAGE>
CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HILLMAN MEDICAL VENTURES 1990 L.P.
     I.D. #51-0324537

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     176,470

8      Shared Voting Power


9.     Sole Dispositive Power
     176,470

10      Shared Dispositve Power


11      Aggregate Amount Beneficially Owned by Each Reporting Person
     176,470

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .3%

14      Type of Reporting Person
     PN

Page 2
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HILLMAN MEDICAL VENTURES 1991 L.P.
     I.D. #51-0337941

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5     Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     486,622

8      Shared Voting Power


9      Sole Dispositive Power
     486,622

10      Shared  Dispositve Power


11      Aggregate Amount Beneficially Owned by Each Reporting Person
     486,622

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .8%

14      Type of Reporting Person
     PN
Page 3
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HILLMAN MEDICAL VENTURES 1992 L.P.
     I.D. #51-0338291

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4     Source of Funds
     OO

5     Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     110,522

8      Shared Voting Power


9      Sole Dispositive Power
     110,522

10      Shared Dispositve Power


11      Aggregate Amount Beneficially Owned by Each Reporting Person
     110,522

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .2%

14      Type of Reporting Person
     PN

Page 4
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HILLMAN MEDICAL VENTURES 1994 L.P.
     I.D. #51-0353407

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     1,094,700

8      Shared Voting Power


9      Sole Dispositive Power
     1,094,700

10      Shared  Dispositve Power


11      Aggregate Amount Beneficially Owned by Each Reporting Person
     1,094,700

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     1.7%
14      Type of Reporting Person
     PN

Page 5
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HILLMAN MEDICAL VENTURES 1995 L.P.
     I.D. #51-0364601

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     1,478,150

8      Shared Voting Power


9      Sole Dispositive Power
     1,478,150

10      Shared Dispositve Power


11      Aggregate Amount Beneficially Owned by Each Reporting Person
     1,478,150

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     2.3%

14      Type of Reporting Person
     PN

Page 6
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HILLMAN/DOVER LIMITED PARTNERSHIP
     I.D. #51-0286294

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
      OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     367,445

8      Shared Voting Power
     3,346,464

9      Sole Dispositive Power
     367,445

10      Shared Dispositve Power
     3,346,464

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     3,713,909

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
13      Percent of Class Represented by Amount in Row (11)
     5.7%

14      Type of Reporting Person
     PN

Page 7
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     CASHON BIOMEDICAL ASSOCIATES L.P.     
     I.D. #23-2555178

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power


8      Shared Voting Power
     3,346,464

9      Sole Dispositive Power


10      Shared Dispositve Power
     3,346,464

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     3,346,464

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     5.2%

14      Type of Reporting Person
     PN

Page 8
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HILLMAN PROPERTIES WEST, INC.     
     I.D. #51-0124111

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     20,625

8      Shared Voting Power
     

9      Sole Dispositive Power
     20,625

10      Shared Dispositve Power
     

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     20,625

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .03%

14      Type of Reporting Person
     CO

Page 9
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HCC INVESTMENTS, INC.     
     I.D. #51-0259668

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     4,125

8      Shared Voting Power
     

9      Sole Dispositive Power
     4,125

10      Shared Dispositve Power
     
11      Aggregate Amount Beneficially Owned by Each Reporting Person
     4,125

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .006%

14      Type of Reporting Person
     CO

Page 10
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     JULIET CHALLENGER, INC.     
     I.D. #51-0256786

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     4,363,207

8      Shared Voting Power
     

9      Sole Dispositive Power
     4,363,207

10      Shared Dispositve Power
     

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     4,363,207

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     6.8%

14      Type of Reporting Person
     CO

Page 11
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     WILMINGTON SECURITIES, INC.
     I.D. #51-0114700

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power


8      Shared Voting Power
     3,734,534

9      Sole Dispositive Power

10      Shared Dispositve Power
     3,734,534

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     3,734,534

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     5.8%

14      Type of Reporting Person
     CO

Page 12
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     WILMINGTON INVESTMENTS, INC.
     I.D. #51-0344688

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Delaware

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power


8      Shared Voting Power
     8,101,866

9      Sole Dispositive Power

10      Shared Dispositve Power
     8,101,866

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     8,101,866

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     12.5%

14      Type of Reporting Person
     CO

Page 13
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     THE HILLMAN COMPANY
     I.D. #25-1011286

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Pennsylvania

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power


8      Shared Voting Power
     8,101,866

9      Sole Dispositive Power


10      Shared Dispositve Power
     8,101,866

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     8,101,866

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     12.5%

14      Type of Reporting Person
     CO

Page 14
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person
     HENRY L. HILLMAN, ELSIE HILLIARD HILLMAN & C. G. GREFENSTETTE,
     TRUSTEES OF THE HENRY L. HILLMAN TRUST U/A DATED NOVEMBER
     18, 1985I.D. #18-2145466

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     Pennsylvania

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     116,325

8      Shared Voting Power
     8,101,866

9      Sole Dispositive Power
     116,325

10      Shared Dispositve Power
     8,101,866

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     8,218,191

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     12.7%

14      Type of Reporting Person
     OO

Page 15
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

C. G. GREFENSTETTE and THOMAS G. BIGLEY, TRUSTEES U/A/T DATED 11/16/64 FOR 
AUDREY HILLIARD HILLMAN          I.D. #25-6064937

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     38,775     
8      Shared Voting Power
     

9      Sole Dispositive Power
     38,775

10      Shared Dispositve Power
     

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     38,775

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .06%

14      Type of Reporting Person
     OO

Page 16
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

C. G. GREFENSTETTE and THOMAS G. BIGLEY, TRUSTEES U/A/T DATED 11/16/64 FOR 
JULIET LEA HILLMAN               I.D. #25-6064939

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     38,775     

8      Shared Voting Power
     

9      Sole Dispositive Power
     38,775

10      Shared Dispositve Power
     

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     38,775

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .06%

14      Type of Reporting Person
     OO

Page 17
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

C. G. GREFENSTETTE and THOMAS G. BIGLEY, TRUSTEES U/A/T DATED 11/16/64 FOR 
HENRY L. HILLMAN, JR.               I.D. #25-6064938

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With
7      Sole Voting Power
     38,775     

8      Shared Voting Power
     

9      Sole Dispositive Power
     38,775

10      Shared Dispositve Power
     

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     38,775

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .06%

14      Type of Reporting Person
     OO

Page 18
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

C. G. GREFENSTETTE and THOMAS G. BIGLEY, TRUSTEES U/A/T DATED 11/16/64 FOR 
WILLIAM TALBOTT HILLMAN          I.D. #25-6064940

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     38,775     

8      Shared Voting Power
     

9      Sole Dispositive Power
     38,775

10      Shared Dispositve Power
     

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     38,775

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .06%

14      Type of Reporting Person
     OO

Page 19
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     C. G. GREFENSTETTE
     I.D. ####-##-####

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     

8      Shared Voting Power
     8,373,291

9      Sole Dispositive Power
     

10      Shared Dispositve Power
     8,373,291

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     8,373,291

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     13.0%

14      Type of Reporting Person
     IN

Page 20
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HENRY L. HILLMAN
     I.D. ####-##-####

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power


8      Shared Voting Power
     8,218,191

9      Sole Dispositive Power


10      Shared Dispositive Power
     8,218,191

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     8,218,191

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     12.7%

14      Type of Reporting Person
     IN

Page 21
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     ELSIE HILLIARD HILLMAN
     I.D. ####-##-####

2 Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO
5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power


8      Shared Voting Power
     8,218,191

9      Sole Dispositive Power


10      Shared Dispositive Power
     8,218,191

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     8,218,191

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     12.7%

14      Type of Reporting Person
     IN

Page 22
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     THOMAS G. BIGLEY
     I.D. #

2 Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power


8      Shared Voting Power
     155,100

9      Sole Dispositive Power


10      Shared Dispositive Power
     155,100

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     155,100

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     .2%

14      Type of Reporting Person
     IN

Page 23
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     CHARLES G. HADLEY
     I.D. ####-##-####

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only
4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     250

8      Shared Voting Power
     3,346,464

9      Sole Dispositive Power
     250

10      Shared Dispositve Power
     3,346,464

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     3,346,714

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     5.2%

14      Type of Reporting Person
     IN

Page 24
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     HAL S. BRODERSON
     I.D. ####-##-####

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
     OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     1,100

8      Shared Voting Power
     3,346,464

9      Sole Dispositive Power
     1,100

10      Shared Dispositve Power
     3,346,464

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     3,347,564

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     5.2%

14      Type of Reporting Person
     IN

Page 25
<PAGE>

CUSIP NO. 232824102

1      Name of Reporting Person S.S. or I.R.S. Identification No. of above 
Person

     RONALD J. BRENNER
     I.D. ####-##-####

2      Check the Appropriate Box if Member of a Group        (a)  [   X   
]          (b)  [       ]

3      SEC Use Only

4      Source of Funds
      OO

5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 
2(d) or 2(e)                                                        [       ]
6       Citizenship or Place of Organization
     U.S.

Number of Shares Beneficially Owned by Each Reporting Person With

7      Sole Voting Power
     88,200

8      Shared Voting Power
     3,346,464

9      Sole Dispositive Power
     88,200

10      Shared Dispositve Power
     3,346,464

11      Aggregate Amount Beneficially Owned by Each Reporting Person
     3,434,664

12      Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares

13      Percent of Class Represented by Amount in Row (11)
     5.3%

14      Type of Reporting Person
     IN

Page 26
<PAGE>

SCHEDULE 13D


     This statement ("Statement") constitutes Amendment No. 1 to Schedule 13D 
filed with the Securities and Exchange Commission (the "Commission") on 
January 18, 1999 (the "Filing").

Item 1.     Security and Issuer

     This Statement relates to the Common Stock, $.01 par value, of Cytogen 
Corporation, a Delaware corporation (the "Issuer").  The address of the 
Issuer's principal executive office is 600 College Road East, Princeton, New 
Jersey 08540-5308, and the Issuer's ticker symbol is CYTO.

Item 2.     Identity and Background

     (a)     Names of persons filing (individually, the "Registrant" and 
collectively, the "Registrants"):

          Hillman Medical Ventures 1990 L.P., a Delaware limited
          partnership, whose general partners are Hillman/Dover
          Limited Partnership and Cashon Biomedical Associates L.P.

          Hillman Medical Ventures 1991 L.P., a Delaware limited
          partnership, whose general partners are Hillman/Dover
          Limited Partnership and Cashon Biomedical Associates L.P.

          Hillman Medical Ventures 1992 L.P., a Delaware limited
          partnership, whose general partners are Hillman/Dover
          Limited Partnership and Cashon Biomedical Associates L.P.

          Hillman Medical Ventures 1994 L.P., a Delaware limited
          partnership, whose general partners are Hillman/Dover
          Limited Partnership and Cashon Biomedical Associates L.P.

          Hillman Medical Ventures 1995 L.P., a Delaware limited
          partnership, whose general partners are Hillman/Dover
          Limited Partnership and Cashon Biomedical Associates L.P.

          Hillman/Dover Limited Partnership, a Delaware limited
          partnership whose general partner is Wilmington Securities,
          Inc.

          Cashon Biomedical Associates L.P., a Delaware limited
          partnership whose general partners are Charles G. Hadley,
          Hal S. Broderson and Ronald J. Brenner.

          Hillman Properties West, Inc., a Delaware corporation, a
          wholly-owned subsidiary of Wilmington Securities, Inc.

HCC Investments, Inc., a Delaware corporation, a wholly-owned subsidiary of 
Wilmington Investments, Inc.

Juliet Challenger, Inc., a Delaware corporation, a wholly-owned subsidiary of 
Wilmington Investments, Inc.

          Wilmington Securities, Inc., a Delaware corporation, a
          wholly-owned subsidiary of Wilmington Investments, Inc.

          Wilmington Investments, Inc., a Delaware corporation, a
          wholly-owned subsidiary of The Hillman Company.

          The Hillman Company, a Pennsylvania corporation controlled by
          Henry L. Hillman, Elsie Hilliard Hillman and C. G. Grefenstette,
          as Trustees of the Henry L. Hillman Trust U/A dated
          November 18, 1985.

          Henry L. Hillman, Elsie Hilliard Hillman and C. G.
          Grefenstette, Trustees of the Henry L. Hillman Trust U/A
          dated November 18, 1985 (the "1985 Trust").

C. G. Grefenstette and Thomas G. Bigley, Trustees U/A/T dated November 16, 
1964 for Audrey Hilliard Hillman (the "AHH Trust")

C. G. Grefenstette and Thomas G. Bigley, Trustees U/A/T dated November 16, 
1964 for Juliet Lea Hillman (the "JLH Trust")

C. G. Grefenstette and Thomas G. Bigley, Trustees U/A/T dated November 16, 
1964 for Henry L. Hillman, Jr. (the "HLHJr. Trust")

C. G. Grefenstette and Thomas G. Bigley, Trustees U/A/T dated November 16, 
1964 for William Talbott Hillman (the "WTH Trust")

          C. G. Grefenstette

          Henry L. Hillman

          Elsie Hilliard Hillman

Thomas G. Bigley

          Charles G. Hadley

          Hal S. Broderson
          Ronald J. Brenner

The name, position, business address and citizenship of each director and 
executive officer of the entities listed above, each controlling person of 
such entities and each director and executive officer of any person or 
corporation in control of said entities, is attached hereto as Exhibit 1.

     (b)     Business Address

          The addresses of the Registrants are as follows:

     The Hillman Company, the 1985 Trust, the AAH Trust, the JLH
Trust, the HLHJr. Trust and the WTH Trust are each located at:
          1900 Grant Building
          Pittsburgh, Pennsylvania 15219

     Hillman Properties West, Inc., HCC Investments, Inc., Juliet
Challenger, Inc., Wilmington Securities, Inc., Wilmington
          Investments, Inc., Hillman/Dover Limited Partnership,
          Hillman Medical Ventures 1990 L.P., Hillman Medical
          Ventures 1991 L.P., Hillman Medical Ventures 1992 L.P.,
          Hillman Medical Ventures 1994 L.P. and Hillman Medical
          Ventures 1995 L.P. are located at:
          824 Market Street, Suite 900
          Wilmington, Delaware 19801

          Cashon Biomedical Associates L.P., Charles G. Hadley,
          Hal S. Broderson and Ronald J. Brenner are located at:
          One Tower Bridge, Suite 1350
          100 Front Street
          Conshohocken, Pennsylvania 19428

          C. G. Grefenstette
          2000 Grant Building
          Pittsburgh, Pennsylvania 15219

          Thomas G. Bigley
          One Oxford Centre, 28th Floor
          Pittsburgh, Pennsylvania 15219

          Henry L. Hillman
          2000 Grant Building
          Pittsburgh, Pennsylvania 15219

          Elsie Hilliard Hillman
          2000 Grant Building
          Pittsburgh, Pennsylvania 15219

     (c)     Principal occupation or employment

     The principal occupations of the limited partnerships listed in response 
to Item 2(a) are:  investments in medical area.

     The principal occupations of the corporations, listed in response to Item 
2(a) are:  diversified investments and operations.

     The principal occupations of the 1985 Trust, the AAH Trust, the JLH
Trust, the HLHJr. Trust and the WTH Trust are:  diversified investments and 
operations.

          Charles G. Hadley
          General Partner, Cashon Biomedical Associates L.P.

          Hal S. Broderson
          General Partner, Cashon Biomedical Associates L.P.

          Ronald J. Brenner
          General Partner, Cashon Biomedical Associates L.P.

          C. G. Grefenstette
          See Exhibit 1

          Thomas G. Bigley
          Managing Partner, Ernst & Young

          Henry L. Hillman
          See Exhibit 1

          Elsie Hilliard Hillman
          See Exhibit 1

     (d)     Criminal convictions

     None of the persons named in Item 2(a)(including Exhibit 1) have been 
convicted in a criminal proceeding in the last five years.

     (e)     Civil proceedings

     None of the persons listed in response to Item 2(a) (including Exhibit 1) 
have in the last five years been subject to a judgment, decree or final order 
as described           in Item 2, subsection (e) of Schedule 13D.

     (f)     Citizenship

          The 1985 Trust, the AAH Trust, the JLH
Trust, the HLHJr. Trust and the WTH Trust are Pennsylvania trusts.

     Hillman Properties West, Inc., HCC Investments, Inc., Juliet
Challenger, Inc., Wilmington Securities, Inc. and Wilmington
          Investments, Inc. are Delaware corporations.

          The Hillman Company is a Pennsylvania corporation.

     Hillman/Dover Limited Partnership, Cashon Biomedical Associates L.P., 
Hillman Medical Ventures 1990 L.P., Hillman Medical Ventures 1991 L.P., 
Hillman Medical Ventures 1992 L.P., Hillman Medical Ventures 1994 L.P.     and 
Hillman Medical Ventures 1995 L.P. are Delaware limited partnerships.

     C. G. Grefenstette, Thomas G. Bigley, Henry L. Hillman, Elsie 
Hilliard     Hillman, Charles G. Hadley, Hal S. Broderson and Ronald J. 
Brenner are U.S. citizens.

Item 3.     Source and Amount of Funds or Other Consideration

          None.

Item 4.     Purpose of Transaction

          Pursuant to a Securities Purchase Agreement, dated as of December 
31,
          1998, Juliet Challenger, Inc. purchased 2,666,667 shares of the 
Issuer's
          Common Stock for a purchase price of $2,000,000, or $.75 per share.

Except as set forth above, the Registrants have no present plans or proposals 
which relate to or would result in (a) the acquisition by any person of 
additional securities of the Issuer or the disposition of securities of the 
Issuer, (b) an extraordinary corporate transaction, such as a merger, 
reorganization, or liquidation involving the Issuer or any of its 
subsidiaries, (c) a sale or transfer of a material amount of the assets of the 
Issuer or any of its subsidiaries, (d) any change in the present Board of 
Directors or Management of the Issuer including any plans or proposals to 
change the number or term of Directors or to fill any existing vacancies on 
the Board, (e) any material change in the present capitalization or dividend 
policy of the Issuer, (f) any other material change in the Issuer's business 
or corporate structure, (g) changes in the Issuer's charter, by-laws or 
instruments corresponding thereto or other actions which may impede the 
acquisition of control of the Issuer by any person, (h) causing a class of 
securities of the Issuer to be delisted from a national securities exchange or 
to cease to be authorized to be quoted in an inter-dealer quotation system of 
a registered national securities association, (i) a class of equity securities 
of the Issuer becoming eligible for termination of registration pursuant to 
Section 12(g)(4) of the Act of 1933, or (j) any action similar to those 
enumerated above.

Item 5.     Interest in Securities of the Issuer

     (a)     Beneficial Ownership

     The following is a list of the Issuer's Common Stock of which each 
Registrant is a direct, beneficial owner.  It includes the number of shares 
held and the percentage
          of the class of such shares that are held by such Registrant.

<TABLE>
<CAPTION><S><C><C>

          Name                     Number of Shares      % of Class of Shares

          Hillman Medical
          Ventures 1990 L.P.          176,470          .3%

          Hillman Medical
          Ventures 1991 L.P.          486,622     .8%

          Hillman Medical
          Ventures 1992 L.P.          110,522          .2%

          Hillman Medical
          Ventures 1994 L.P.          1,094,700          1.7%

          Hillman Medical
          Ventures 1995 L.P.          1,478,150     2.3%

          Hillman/Dover367,445.6%
          Limited Partnership

          Hillman Properties20,625.03%
          West, Inc.

          HCC Investments, Inc.4,125.006%

          Juliet Challenger, Inc.4,363,2076.6%

          The 1985 Trust116,325.2%

          The AAH Trust38,775.06%

          The JLH Trust38,775.06%

          The HLHJr. Trust38,775.06%
          
          The WTH Trust38,775.06%

          Charles G. Hadley250> .001%

          Hal S. Broderson1,100> .001%

          Ronald J. Brenner88,200.1%

</TABLE>

     (b)     Power to Vote or Dispose of Shares

Each person listed above in response to Item 5(a) has the sole power to vote 
and to direct the vote and the sole power to dispose of and direct the 
disposition of those shares except as follows:

          (i)Wilmington Securities, Inc., Wilmington Investments, Inc., The 
Hillman Company, Henry L. Hillman, as settlor and Trustee of the 1985 Trust, 
and Elsie Hilliard Hillman and C. G. Grefenstette, as Trustees of the 1985 
Trust, may be deemed to share voting and disposition power regarding 8,101,866 
shares of Common Stock held beneficially by Hillman Properties West, Inc., HCC 
Investments, Inc., and Juliet Challenger, Inc., and Hillman Medical Ventures 
1990 L.P., Hillman Medical Ventures 1991 L.P., Hillman Medical Ventures 1992 
L.P., Hillman Medical Ventures 1994 L.P. and Hillman Medical Ventures 1995 
L.P., whose general partners are Hillman/Dover Limited Partnership and Cashon 
Biomedical Associates L.P.  Wilmington Securities, Inc. is the general partner 
of Hillman/Dover Limited Partnership.
          (ii)As trustees of the 1985 Trust, Henry L. Hillman, Elsie Hilliard 
Hillman and C. G. Grefenstette may be deemed to own beneficially and share 
voting and disposition power over 8,218,191 shares of Common Stock.

          (iii)C. G. Grefenstette and Thomas G. Bigley, as Trustees, may be 
deemed to share voting and disposition power regarding the aggregate of 
155,100 shares held in trust for the AHH Trust, the JLH Trust, the HLHJr. 
Trust, and the WTH Trust.

          (iv)Cashon Biomedical Associates L.P., Charles G. Hadley, Hal S. 
Broderson and Ronald J. Brenner may be deemed to own beneficially and share 
voting and disposition power over 3,346,464 shares of Common Stock.

     (c), (d) and (e).  Not applicable.

Item 6.Contracts, Arrangements, Understandings of Relationships With Respect 
to Securities of the Issuer

     None.

Item 7.     Material to be Filed as Exhibits

     Exhibit 1.Information concerning officers and directors of reporting 
persons and certain affiliates thereof.

     Exhibit 2.Securities Purchase Agreement, dated as of December 31, 1998.




<PAGE>SIGNATURES

     After reasonable inquiry and to the best of my knowledge and belief, I 
certify that the information set forth in this statement is true, complete and 
correct.

                         HILLMAN MEDICAL VENTURES 1990 L.P.,
                         HILLMAN MEDICAL VENTURES 1991 L.P.,
                         HILLMAN MEDICAL VENTURES 1992 L.P.,
                         HILLMAN MEDICAL VENTURES 1994 L.P.,
                         and HILLMAN MEDICAL VENTURES 1995 L.P.

                         By Hillman/Dover Limited Partnership,
                         a General Partner

                         By Wilmington Securities, Inc., the sole
                         General Partner

                              /s/ Andrew H. McQuarrie
                         By _________________________________________
                              Andrew H. McQuarrie, Vice President

                         By Cashon Biomedical Associates L.P.,
                         a General Partner

                              /s/ Charles G. Hadley
                         By _________________________________________
                              Charles G. Hadley, General Partner

                              /s/ Hal S. Broderson
                    By _________________________________________
                         Hal S. Broderson, General Partner

                              /s/ Ronald J. Brenner
                    By _________________________________________
                         Ronald J. Brenner, General Partner 

     
                    HILLMAN/DOVER LIMITED PARTNERSHIP

                    By Wilmington Securities, Inc.,
                    the sole General Partner

                              /s/ Andrew H. McQuarrie
                    By _________________________________________
                         Andrew H. McQuarrie, Vice President
                    CASHON BIOMEDICAL ASSOCIATES L.P.

                              /s/ Charles G. Hadley
                    By _________________________________________
                         Charles G. Hadley, General Partner

                              /s/ Hal S. Broderson
                    By _________________________________________
                         Hal S. Broderson, General Partner

                              /s/ Ronald J. Brenner
                    By _________________________________________
                         Ronald J. Brenner, General Partner 


                    HILLMAN PROPERTIES WEST, INC.

                              /s/ Andrew H. McQuarrie
                    By _________________________________________
                         Andrew H. McQuarrie, Vice President


                    HCC INVESTMENTS, INC.

                              /s/ Andrew H. McQuarrie
                    By _________________________________________
                         Andrew H. McQuarrie, Vice President


                    JULIET CHALLENGER, INC.

                              /s/ Andrew H. McQuarrie
                    By _________________________________________
                         Andrew H. McQuarrie, Vice President


                    WILMINGTON SECURITIES, INC.

                              /s/ Andrew H. McQuarrie
                    By _________________________________________
                         Andrew H. McQuarrie, Vice President


                    WILMINGTON INVESTMENTS, INC.

                              /s/ Andrew H. McQuarrie
                    By _________________________________________
                         Andrew H. McQuarrie, Vice President


                    THE HILLMAN COMPANY

                              /s/ Lawrence M. Wagner
                    By _________________________________________
                         Lawrence M. Wagner, President


                    HENRY L. HILLMAN, ELSIE HILLIARD HILLMAN
& C. G. GREFENSTETTE, TRUSTEES OF THE HENRY L. HILLMAN TRUST U/A DATED 
NOVEMBER 18, 1985

                              /s/ C. G. Grefenstette
                    By _________________________________________
                         C. G. Grefenstette, Trustee


                    C. G. GREFENSTETTE AND THOMAS G. BIGLEY, TRUSTEES U/A/T 
DATED 11/16/64 FOR EACH OF AUDREY HILLIARD HILLMAN, JULIET LEA HILLMAN, HENRY 
L. HILLMAN, JR. and WILLIAM TALBOTT HILLMAN

                              /s/ C. G. Grefenstette
                         By _________________________________________
                              C. G. Grefenstette, Trustee

                              /s/ Thomas G. Bigley
                         By _________________________________________
                              Thomas G. Bigley


                         /s/ C. G. Grefenstette
                    ____________________________________________
                    C. G. Grefenstette

                         /s/ Thomas G. Bigley
                    ____________________________________________
                    Thomas G. Bigley

                         /s/ Henry L. Hillman                    
                    ____________________________________________
                    Henry L. Hillman

                         /s/ Elsie Hilliard Hillman
                         ____________________________________________
                    Elsie Hilliard Hillman 

                         /s/ Charles G. Hadley
                    ____________________________________________
                    Charles G. Hadley

                         /s/ Hal S. Broderson
                    ____________________________________________
                    Hal S. Broderson

                         /s/ Ronald J. Brenner
                    ____________________________________________
                    Ronald J. Brenner


EXHIBIT 1

<TABLE>
<CAPTION>

PRINCIPAL OFFICERS AND DIRECTORS OF
THE HILLMAN COMPANY, ALL OF WHOM ARE U.S. CITIZENS

Name and Address                    Title

<S><C>

Henry L. Hillman                    Chairman of the Executive Committee
2000 Grant Building               and Director
Pittsburgh, Pennsylvania 15219

C. G. Grefenstette               Chairman of the Board and
2000 Grant Building               Director
Pittsburgh, Pennsylvania 15219

Lawrence M. Wagner               President, Chief Executive Officer
2000 Grant Building               and Director
Pittsburgh, Pennsylvania 15219

H. Vaughan Blaxter, III               Vice President, Secretary, General
1900 Grant Building               Counsel and Director
Pittsburgh, Pennsylvania 15219

Mark J. Laskow                    Vice President and Director
1900 Grant Building
Pittsburgh, Pennsylvania 15219

Anthony J. Burlando               Vice President - Risk Management
1900 Grant Building
Pittsburgh, Pennsylvania 15219

James R. Philp                    Vice President - Personnel and
2000 Grant Building               Administration
Pittsburgh, Pennsylvania 15219

Richard M. Johnston               Vice President - Investments and
2000 Grant Building               Director
Pittsburgh, Pennsylvania 15219

<PAGE>John W. Hall                    Vice President - Accounting and
1800 Grant Building               Information Services
Pittsburgh, Pennsylvania 15219

Timothy O. Fisher                    Vice President
1900 Grant Building
Pittsburgh, Pennsylvania 15219

Bruce I. Crocker                    Vice President
1800 Grant Building
Pittsburgh, Pennsylvania 15219

Denis P. McCarthy                    Vice President
1900 Grant Building
Pittsburgh, Pennsylvania 15219

Timothy P. HallVice President
2000 Grant Building
Pittsburgh, PA 15219

Joseph C. ManzingerVice President
2000 Grant Building
Pittsburgh, PA 15219

Maurice J. WhiteVice President, Shareholder Services
1800 Grant Building
Pittsburgh, PA 15219

Charles H. Bracken, Jr.               Vice President
2000 Grant Building
Pittsburgh, Pennsylvania 15219

Eric C. Johnson               Treasurer
2000 Grant Building
Pittsburgh, Pennsylvania 15219

D. Richard Roesch                    Assistant Treasurer
1800 Grant Building
Pittsburgh, Pennsylvania 15219 

Michael S. Adamcyk               Assistant Secretary and
2000 Grant Building               Assistant Treasurer
Pittsburgh, Pennsylvania 15219

<PAGE>Mary Black Strong                    Assistant Treasurer
2000 Grant Building
Pittsburgh, Pennsylvania 15219

Carol J. Cusick Riley               Vice President, Associate General
1900 Grant Building               Counsel and Assistant Secretary
Pittsburgh, Pennsylvania 15219 

Cornel Conley                    Controller - Corporate
1800 Grant Building
Pittsburgh, Pennsylvania 15219

Mark M. Poljak                    Controller - Taxes
1800 Grant Building
Pittsburgh, Pennsylvania 15219

Elsie H. Hillman                    Director
2000 Grant Building
Pittsburgh, Pennsylvania 15219 

Audrey Hillman FisherDirector
2000 Grant Building
Pittsburgh, PA 15219


PRINCIPAL OFFICERS AND DIRECTORS OF
WILMINGTON INVESTMENTS, INC., ALL OF WHOM ARE U.S. CITIZENS

H. Vaughan Blaxter, III          President and Secretary
1900 Grant Building
Pittsburgh, Pennsylvania 15219

Andrew H. McQuarrie               Vice President, Chief Financial Officer,
824 Market Street, Suite 900          Treasurer and Director
Wilmington, Delaware 19801

Lario M. Marini                    Senior Vice President and Director
Wilmington Trust Center
Wilmington, Delaware 19801 

Richard H. Brown                    Assistant Vice President and
824 Market Street, Suite 900          Assistant Secretary
Wilmington, Delaware 19801

<PAGE>Eric C. Johnson               Assistant Secretary and
2000 Grant Building               Assistant Treasurer
Pittsburgh, Pennsylvania 15219

Jody B. Cosner                    Assistant Secretary
824 Market Street, Suite 900
Wilmington, Delaware 19801

Joan E. Bachner                    Assistant Treasurer
824 Market Street, Suite 900
Wilmington, Delaware 19801

Darlene ClarkeDirector
824 Market Street, Suite 900
Wilmington, Delaware 19801


PRINCIPAL OFFICERS AND DIRECTORS OF
WILMINGTON SECURITIES, INC., ALL OF WHOM ARE U.S. CITIZENS

H. Vaughan Blaxter, III          President
1900 Grant Building
Pittsburgh, Pennsylvania 15219

Andrew H. McQuarrie               Vice President, Chief Financial
824 Market Street, Suite 900          Officer, Treasurer and Director
Wilmington, Delaware 19801

Lario M. Marini                    Senior Vice President and Director
Wilmington Trust Center
Wilmington, Delaware 19801

Richard H. Brown                    Assistant Vice President and
824 Market Street, Suite 900          Assistant Secretary
Wilmington, Delaware 19801 

Marian F. Dietrich               Secretary
1900 Grant Building
Pittsburgh, Pennsylvania 15219 

Eric C. Johnson               Assistant Secretary and
2000 Grant Building               Assistant Treasurer
Pittsburgh, Pennsylvania 15219

<PAGE>Jody B. Cosner                    Assistant Secretary
824 Market Street, Suite 900
Wilmington, Delaware 19801

Joan E. Bachner                    Assistant Treasurer
824 Market Street, Suite 900
Wilmington, Delaware 19801

Darlene ClarkeDirector
824 Market Street, Suite 900
Wilmington, Delaware 19801


PRINCIPAL OFFICERS AND DIRECTORS OF
HCC INVESTMENTS, INC. AND JULIET CHALLENGER, INC.,
ALL OF WHOM ARE U.S. CITIZENS

H. Vaughan Blaxter, III          President and Secretary
1900 Grant Building
Pittsburgh, Pennsylvania 15219

Andrew H. McQuarrie               Vice President, Chief Financial
824 Market Street, Suite 900          Officer, Treasurer and Director
Wilmington, Delaware 19801

Lario M. Marini                    Senior Vice President and Director
Wilmington Trust Center
Wilmington, Delaware 19801

Richard H. Brown                    Assistant Vice President and
824 Market Street, Suite 900          Assistant Secretary
Wilmington, Delaware 19801 

Eric C. Johnson               Assistant Secretary and
2000 Grant Building               Assistant Treasurer
Pittsburgh, Pennsylvania 15219

Jody B. Cosner                    Assistant Secretary
824 Market Street, Suite 900
Wilmington, Delaware 19801

Joan E. Bachner                    Assistant Treasurer
824 Market Street, Suite 900
Wilmington, Delaware 19801

Darlene ClarkeDirector
824 Market Street, Suite 900
Wilmington, Delaware 19801


PRINCIPAL OFFICERS AND DIRECTORS OF
HILLMAN PROPERTIES WEST, INC., ALL OF WHOM
ARE U.S. CITIZENS

H. Vaughan Blaxter, III          President, Secretary and Director
1900 Grant Building
Pittsburgh, Pennsylvania 15219

Andrew H. McQuarrie               Vice President, Treasurer
824 Market Street, Suite 900          and Director
Wilmington, Delaware 19801

Lario M. Marini                    Senior Vice President and Director
Wilmington Trust Center
Wilmington, Delaware 19801

Dale L. ClemensVice President and General Manager,
2011 Palomar RoadCarlsbad
Carlsbad, California 92009

Stephen P. SmithVice President
2030 Main Street, Suite 640
Irvine, California 92614

Christopher D. HarrisVice President
1800 Grant Building
Pittsburgh, Pennsylvania 15219

Richard H. Brown                    Assistant Vice President and
824 Market Street, Suite 900          Assistant Secretary
Wilmington, Delaware 19801 

Eric C. Johnson               Assistant Secretary and
2000 Grant Building               Assistant Treasurer
Pittsburgh, Pennsylvania 15219

Michael S. Adamcyk               Assistant Treasurer
2000 Grant Building
Pittsburgh, Pennsylvania 15219

Jody B. Cosner                    Assistant Secretary
824 Market Street, Suite 900
Wilmington, Delaware 19801

Joan E. Bachner                    Assistant Treasurer
824 Market Street, Suite 900
Wilmington, Delaware 19801

Russell W. Ayres, IIIDirector
1900 Grant Building
Pittsburgh, Pennsylvania 15219

Carol Cusick RileyDirector
1900 Grant Building
Pittsburgh, Pennsylvania 15219


GENERAL PARTNERS OF:  HILLMAN MEDICAL VENTURES 1990 L.P.,
HILLMAN MEDICAL VENTURES 1991 L.P., HILLMAN MEDICAL VENTURES
1992 L.P., HILLMAN MEDICAL VENTURES 1994 L.P., and HILLMAN
MEDICAL VENTURES 1995 L.P., BOTH OF WHICH WERE ORGANIZED
IN THE U.S.

Hillman/Dover Limited Partnership
824 Market Street, Suite 900
Wilmington, Delaware 19801

Cashon Biomedical Associates L.P.
One Tower Bridge, Suite 1350
100 Front Street
Conshohocken, Pennsylvania 19428


GENERAL PARTNER OF HILLMAN/DOVER LIMITED PARTNERSHIP, WHICH
WAS ORGANIZED IN THE U.S.

Wilmington Securities, Inc.
824 Market Street, Suite 900
Wilmington, Delaware 19801


<PAGE>GENERAL PARTNERS OF CASHON BIOMEDICAL ASSOCIATES L.P.,
ALL OF WHOM ARE U.S. CITIZENS

Charles G. Hadley
One Tower Bridge, Suite 1350
100 Front Street
West Conshohocken, Pennsylvania 19428

Hal S. Broderson
One Tower Bridge, Suite 1350
100 Front Street
West Conshohocken, Pennsylvania 19428

Ronald J. Brenner
One Tower Bridge, Suite 1350
100 Front Street
West Conshohocken, Pennsylvania 19428


TRUSTEES OF THE HENRY L. HILLMAN TRUST U/A
DATED NOVEMBER 18, 1985, ALL OF WHOM ARE U.S. CITIZENS

Henry L. Hillman
2000 Grant Building
Pittsburgh, Pennsylvania 15219

Elsie Hilliard Hillman
2000 Grant Building
Pittsburgh, Pennsylvania 15219

C. G. Grefenstette
2000 Grant Building
Pittsburgh, Pennsylvania 15219


TRUSTEES OF THE FOUR HILLMAN TRUSTS DATED 11/16/64, BOTH
WHOM ARE U.S. CITIZENS

C. G. Grefenstette
2000 Grant Building
Pittsburgh, Pennsylvania 15219

Thomas G. Bigley
One Oxford Centre, 28th floor
Pittsburgh, Pennsylvania 15219
</TABLE>


EXHIBIT 2

SECURITIES PURCHASE AGREEMENT

This Securities Purchase Agreement (this "Agreement"), dated as of December 
31, 1998 is entered into by and between Juliet Challenger, Inc., a Delaware 
corporation with an office at 824 Market Street, Suite 900, Wilmington, 
Delaware 19801 (the "Purchaser") and Cytogen Corporation, a Delaware 
corporation with its principal offices located at 600 College Road East, 
Princeton, New Jersey 08540 (the "Company").

     The Company has offered for sale, and the Purchaser has agreed to 
purchase 2,666,667 shares of Common Stock, par value $.01 per share (the 
"Shares") of the Company on the terms and conditions herein provided.  In 
connection herewith, the Company and the Purchaser hereby agree as follows:

1.     Purchase and Sale of Shares.  Upon the basis of the representations 
subject to the terms and conditions set forth herein, the Company agrees to 
issue and sell the Shares to the Purchaser on the Closing Date (defined 
herein) at $.75 per Share, or an aggregate purchase price of $2,000,000.00 
(the "Purchase Price") and, upon the basis of the representations and 
warranties and subject to the terms and conditions set forth herein, the 
Purchaser agrees to purchase the Shares from the Company on the Closing Date 
at the Purchase Price.

2.     Closing.  The closing of the purchase and sale of the Shares shall take 
place at such place and at such time as the Company and the Purchaser may 
agree (the time and date of the closing being referred to herein as the 
"Closing Date").  Upon payment of the Purchase Price in full in immediately 
available funds by or on behalf of the Purchaser to the Company by wire 
transfer to an account specified by the Company to the Purchaser prior to the 
Closing Date, the Company will promptly cause its transfer agent to deliver to 
the Purchaser within three business days of the Closing Date certificates 
representing the shares of Common Stock in such denominations and registered 
in such names as the Purchaser shall request.

3.     Registration.

(a)On December 30, 1998, the Company's Registration Statement on Form S-1, No. 
338-68759, was declared effective by the Securities and Exchange Commission 
("Commission") (including all exhibits thereto and all documents incorporated 
by reference therein, the "Registration Statement") and includes the 
registration of the original issuance of the Share of Common Stock purchased 
by the Purchaser pursuant to this Agreement.

(b)Promptly after the Closing Date, the Company shall take all requisite 
action to list Shares for trading on the NASDAQ National Market.

4.     Representations and Warranties of the Company.  The Company represents 
and warrants, as of the date hereof and as of the Closing Date, as follows:

     (a)no consent, approval, authorization or order of any court, 
governmental agency or body or arbitrator having jurisdiction over the Company 
or any of the Company's affiliates is required for the execution of this 
Agreement or the sale of the Shares to the Purchaser;
     (b)neither the sale of the Shares nor the performance of the Company's 
other obligations under this Agreement will violate, conflict with, result in 
a breach of, or constitute a default (or an event that, with the giving of 
notice or the lapse of time or both, would constitute a default) under (i) the 
Certificates of Incorporation or By-laws of the Company; (ii) any decree, 
judgment, order or determination of any court, governmental agency or body, or 
arbitrator having jurisdiction over the Company or any of the Company's 
properties or assets; (iii) any law, treaty, rule or regulation applicable to 
the Company (other than the federal securities laws, representations and 
warranties with respect to which are made by the Company, or the requirements 
of the NASDAQ Stock Market); or (iv) the terms of any bond, debenture, note or 
other evidence of indebtedness, or any agreement, stock option or similar plan 
by which the Company is bound or to which any property of the Company is 
subject, in any event above, which violation, conflict or breach would have a 
material adverse effect on the Company;
     (c)the Company has taken all corporate action required to authorize the 
execution and delivery of this Agreement and the performance of its 
obligations hereunder;
     (d)the Company has duly authorized the issuance of the Shares and, when 
issued and delivered to and paid for by the Purchaser in accordance with the 
terms hereof, the Common Stock will be duly and validly issued, fully paid and 
non-assessable;
     (e)the Company's Prospectus dated December 30, 1998, included in the 
Company's Registration Statement on Form S-1 (Registration No. 333-68759 
attached hereto as Exhibit "a"); the Company's Annual Report on Form 10-KA for 
the year ended Decimeter 31, 1997; together with the Company's filings with 
the Securities and Exchange Commission under the Securities Exchange Act of 
1934, as amended (the "Exchange Act"), subsequent to the filing of such Form 
10-KA (the "Disclosure Documents") have been delivered to the Purchaser and, 
as of the date of each such document, such Disclosure Documents do not contain 
any untrue statement of a material fact or omit to state a material fact 
required to be stated therein or necessary to make the statement therein not 
misleading in light of the circumstances in which they were made with respect 
to the Company;
     (f)the Company's financial statements for the year ended Decimeter 31, 
1997, as amended, included in the Disclosure Documents comply in all material 
respects with the applicable requirements of the Exchange Act and have been 
prepared, and fairly present in all material respects the consolidated 
financial condition, results of operations and cash flow of the Company and 
its subsidiaries at the respective dates for the respective periods indicated, 
in accordance with generally accepted accounting principles consistently applied
 throughout such periods (except as may be noted therein) and will not be 
restated any time within the 30-day period following the Closing Date, if 
ever;
     (g)except as set forth in the Disclosure Documents or pursuant to this 
Agreement, (i) the Company has not incurred any material liabilities, direct 
or contingent except in the ordinary course of business and (ii) there has 
been no material adverse change in the properties, business, results of 
operations of financial condition of the Company; and
     (h)as of September 30, 1998 (and without giving effect to the sale of 
Shares of Common Stock hereunder), the Company had a total of 58,602,852 
shares of Common Stock issued and outstanding; approximately 6,694,623 shares 
of Common Stock were reserved for issuance pursuant to existing stock options 
under the Company's current stock option plans or outside of the plans and 
approximately an additional 1,562,080 shares were issuable upon exercise of 
options available for future grant; and 260,000 shares were reserved for 
issuance pursuant to exercise of outstanding warrants.  Subsequent to 
September 30, 1998, the Company has issued additional warrants to purchase 
1,300,000 shares of Common Stock.  In addition, the Company has entered into a 
Private Equity Line Agreement with Kingsbridge Capital Limited which provided 
that the Company may issue, upon satisfaction of certain conditions, up to 
$12,000,000 of its Common Stock.

5.     Conditions of Closing.  The obligations of each party hereunder shall 
be subject to (a) the accuracy in all material respects of the representations 
and warranties of the other party hereto as of the date hereof and as of the 
Closing Date and (b) the performance in all material respects by the other 
party of its obligations hereunder which must be performed prior to the 
Closing Date.

6.     Indemnification.

     (a)The Company agrees to indemnify and hold harmless the Purchaser, each 
person, if any, who controls the Purchaser within the meaning of Section 15 of 
the Act and each officer, director, employee and agent of the Purchaser and of 
any such controlling person against any and all liabilities, claims, damages 
or expenses whatsoever, as incurred arising out of any representation, 
warranty, covenant or undertaking by the Company contained in this Agreement, 
and the Company will reimburse the Purchaser for its reasonable legal and 
other expenses (including the reasonable cost of any investigation and 
preparation, and including the reasonable fees and expenses of counsel) 
incurred in connection therewith.
     (b)The Purchaser agrees to indemnify and hold harmless the Company, each 
person, if any, who controls the Company within the meaning of Section 15 of 
the Act and each officer, director, employee and agent of the Company and of 
any such controlling person against any and all liabilities, claims, damages 
or expenses whatsoever, as incurred arising out of or resulting from any 
breach or alleged breach or other violation or alleged violation of any 
representation, warrant, covenant or undertaking by the Purchaser contained in 
this Agreement, and the Purchaser will reimburse the Company for its 
reasonable legal and other expenses (including the reasonable cost of any 
investigation and preparation, and including the reasonable fees and expenses 
of counsel) incurred in connection therewith.

7.     Miscellaneous.

     (a)This Agreement may be executed in one or more counterparts and such 
counterparts shall constitute but one and the same agreement and authorized 
signatures may be evidenced to the other party by facsimile copies thereof; 
provided that the originally signed signature page of any party is provided to 
the other party within two business days after original execution.
     (b)This Agreement shall inure to the benefit of and be binding upon the 
parties hereto.  This Agreement shall not be assignable by any party hereto 
without the prior written consent of the other party hereto and no other 
person shall have any right or obligation hereunder.
     (c)This Agreement contains the entire agreement between the parties with 
respect to the subject matter hereof and supersedes any prior agreements or 
understandings, whether written or oral, between the parties respecting such 
subject matter.

8.     Governing Law.  This Agreement shall be governed by the internal laws 
of the State of Delaware.

     IN WITNESS WHEREOF, the parties have entered into this Agreement as of 
the date first set forth above.

CYTOGEN Corporation

By:  /s/ H. Joseph Reiser

H. Joseph Reiser, Ph.D., President
and Chief Executive Officer

JULIET CHALLENGER, INC.


By:  /s/ Andrew H. McQuarrie

Andrew McQuarrie
Vice President



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