CYTOGEN CORP
8-K, EX-10.1, 2000-10-05
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                                    Exhibit 10.1


                                       September 29, 2000


Acqua Wellington North American Equities Fund, Ltd.
c/o Fortis Fund Services (Bahamas) Limited
Montague Sterling Centre
East Bay Street, P.O. Box SS-6238
Nassau, Bahamas

Dear Sirs:

      This  letter  sets forth the  agreement  between  Acqua  Wellington  North
American  Equities Fund, Ltd. (the  "Purchaser")  and Cytogen  Corporation  (the
"Company")  regarding  the  purchase  by the  Purchaser  from the Company of the
Company's  common  stock (the "Common  Stock") on the date  hereof.  The parties
agree as follows:

      This Agreement  relates to the purchase by the Purchaser of 902,601 shares
(the "Shares") of the Company's Common Stock for an aggregate  purchase price of
$6,000,000, which purchase is being settled by the parties on the date hereof.

      The Company is a corporation  duly  incorporated,  validly existing and in
good  standing  under  the  laws of  Delaware.  The  Company  has the  requisite
corporate  power and  authority to enter into and perform this  Agreement and to
issue and sell the Shares in accordance  with the terms hereof.  The  execution,
delivery and  performance of this Agreement by the Company and the  consummation
by it of the  transactions  contemplated  hereby  have  been  duly  and  validly
authorized  by all  necessary  corporate  action.  A copy of the  duly  executed
resolutions  of the Board of  Directors  of the  Company is  attached  hereto as
Exhibit "B".  This  Agreement  has been duly executed and delivered on behalf of
the Company by a duly authorized  officer. A copy of a duly executed  incumbency
certificate  of the Company's  duly  authorized  officers is attached  hereto as
Exhibit "C". This Agreement  constitutes,  or shall constitute when executed and
delivered, a valid and binding obligation of the Company enforceable against the
Company in accordance with its terms.

      The Shares have been duly  authorized  by all necessary  corporate  action
and,  when paid for or issued in accordance  with the terms  hereof,  the Shares
shall be validly issued and outstanding,  fully paid and nonassessable,  and the
Purchaser shall be entitled to all rights accorded to a holder of Common Stock.

      The  Company  represents  and  warrants  that  (a) the  Shares  have  been
registered under the Securities Act of 1933, as amended (the "Securities  Act"),
pursuant  to a  registration  statement  on Form  S-3,  Commission  File  Number
333-33436  (the  "Registration  Statement");  and (b) the  Company  has  filed a
prospectus   supplement  to  the   Registration   Statement   (the   "Prospectus
Supplement") in connection  with this  transaction.  Copies of the  Registration
Statement and the Prospectus  Supplement,  each as filed and, in the case of the
Registration  Statement,  declared  effective  by the  Securities  and  Exchange
Commission, are annexed hereto as Exhibits "D" and "E", respectively.

      The Company has taken all action  necessary on its part to list the Shares
for  trading  on the  Nasdaq  system  or  any  relevant  market  or  system,  if
applicable. A copy of the Company's listing application with Nasdaq or any other
relevant market or system is attached hereto as Exhibit "F."

      The Company  will  continue to take all action  necessary  to continue the
listing  or trading of its  Common  Stock on the Nasdaq  National  Market or any
relevant market or system,  if applicable,  and will comply in all respects with
the Company's reporting, listing (including,  without limitation, the listing of
the Shares) or other  obligations  under the rules of the Nasdaq National Market
or any relevant market or system.

      The Company has  delivered  or made  available to the  Purchaser  true and
complete  copies of the filings on Forms 10-K, 10-Q and 8-K filed by the Company
with the Securities and Exchange  Commission since March 28, 2000 (collectively,
the  "Commission  Filings").  The Company has not provided to the  Purchaser any
information which, according to applicable law, rule or regulation,  should have
been  disclosed  publicly by the  Company  but

                                     - 1 -

<PAGE>


which has not been so  disclosed,  other than with  respect to the  transactions
contemplated  by this  Agreement.  As of  their  respective  dates,  each of the
Commission  Filings  complied in all material  respects with the requirements of
the  Securities  Exchange  Act of 1934  (the  "Exchange  Act") and the rules and
regulations of the Commission  promulgated  thereunder and other federal,  state
and local laws, rules and regulations  applicable to such documents,  and, as of
their  respective  dates,  none of the  Commission  Filings  referred  to  above
contained any untrue statement of a material fact or omitted to state a material
fact required to be stated  therein or necessary in order to make the statements
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading.  The financial  statements of the Company included in the Commission
Filings comply as to form in all material  respects with  applicable  accounting
requirements  and the published rules and regulations of the Commission or other
applicable rules and regulations with respect thereto.  No event or circumstance
has occurred or exists with respect to the Company or its  subsidiaries or their
respective businesses, properties, prospects, operations or financial condition,
which,  under applicable law, rule or regulation,  requires public disclosure or
announcement  by the  Company but which has not been so  publicly  announced  or
disclosed.

      The Company will  promptly  notify the  Purchaser of (a) any stop order or
other suspension of the effectiveness of the Registration  Statement and (b) the
happening  of any  event as a result  of which the  prospectus  included  in the
Registration  Statement includes an untrue statement of a material fact or omits
to state a material fact required to be stated therein, or necessary to make the
statements  therein,  in light of the circumstances  under which they were made,
not misleading.

      The Company may issue a press release or otherwise make a public statement
or announcement  with respect to the completion of the transaction  contemplated
hereby; without the prior consent of the Purchaser.

      The Company and the  Purchaser  will  indemnify  each other as provided in
Exhibit "A" attached hereto against  liability with respect to the  Registration
Statement (including, without limitation, the Prospectus Supplement) relating to
the Shares which was sold by the Company to the Purchaser.  For purposes of said
Exhibit A, capitalized terms used therein without definition shall have the same
meanings therein as are ascribed to said terms in this agreement.

      This  Agreement and the legal  relations  between the parties  hereto with
respect to any  purchase of Common  Stock by the  Purchaser  hereunder  shall be
governed and construed in accordance with the  substantive  laws of the State of
New York without giving effect to the conflicts of law principles thereunder.

      Delivery of an  executed  copy of a signature  page to this  Agreement  by
facsimile  transmission  shall be effective  as delivery of a manually  executed
copy of this Agreement and shall be effective and enforceable as the original.

      Please  execute  a  copy  of  this  letter  which,  when  executed  by the
Purchaser, will constitute an agreement between the Company and the Purchaser.

                                       Very truly yours,

                                       CYTOGEN CORPORATION

                                       By:  /s/ H. Joseph Reiser
                                            -------------------------
                                            Name:  H. Joseph Reiser
                                            Title: President and Chief
                                                   Executive Officer

AGREED TO:

PURCHASER:

ACQUA WELLINGTON NORTH
AMERICAN EQUITIES FUND, LTD.

By:  /s/ Anthony L. M. Inder Rieden
     ----------------------------------
      Name:  Anthony L. M. Inder Rieden
      Title: Director

                                      - 2 -

<PAGE>

EXHIBIT 'A'

                            TERMS OF INDEMNIFICATION

(1)   INDEMNIFICATION  BY THE  COMPANY.  The  Company  will  indemnify  and hold
      harmless the Purchaser and each person, if any, who controls the Purchaser
      within the meaning of Section 15 of the Securities Act of 1933, as amended
      (the "Securities  Act"); or Section 20(a) of the Securities  Exchange Act,
      as amended  (the  "Exchange  Act");  from and against any losses,  claims,
      damages, liabilities,  costs and expenses (including,  without limitation,
      reasonable costs of defense and  investigation and all attorneys' fees and
      expenses) to which the Purchaser and each person, if any, who controls the
      Purchaser  may become  subject,  under the  Securities  Act or  otherwise,
      insofar as such  losses,  claims,  damages,  liabilities  and expenses (or
      actions in respect thereof) arise out of; or are based upon (i) any untrue
      statement or alleged  untrue  statement of a material fact  contained,  or
      incorporated  by  reference,  in the  Registration  Statement  relating to
      Shares being sold to the Purchaser  (including the  prospectus  dated June
      14, 2000,  and the  prospectus  supplement  dated  September 29, 2000 (the
      "Prospectus  Supplement") which are a part of the Registration Statement),
      or any amendment or supplement to the Registration  Statement, or (ii) the
      omission or alleged  omission to state in that  Registration  Statement or
      any document  incorporated by reference in the Registration  Statement,  a
      material  fact  required  to be stated  therein or  necessary  to make the
      statements therein not misleading (an "Indemnifiable Matter").

      The Company will reimburse the Purchaser and each such controlling  person
      promptly  upon demand for any legal or other costs or expenses  reasonably
      incurred by the  Purchaser  or the  controlling  person in  investigating,
      defending against, or preparing to defend against any claim relating to an
      Indemnifiable  Matter,  except that the Company  will not be liable to the
      extent such claim,  suit or  proceeding  which  results in a loss,  claim,
      damage,  liability or expense  arises out of, or is based upon,  an untrue
      statement,  alleged  untrue  statement,   omission  or  alleged  omission,
      included in any  Prospectus  Supplement  or any amendment or supplement to
      the  Prospectus  Supplement  in reliance  upon,  and in  conformity  with,
      written  information  furnished  by  the  Purchaser  to  the  Company  for
      inclusion in the Prospectus Supplement.

(2)   INDEMNIFICATION  PROCEDURES.  Promptly after a person receives notice of a
      claim or the  commencement of an action,  suit or proceeding for which the
      person  intends to seek  indemnification  under  Paragraph (a) or (b), the
      person  will  notify  the  indemnifying  party in  writing of the claim or
      commencement of the action, suit or proceeding,  but failure to notify the
      indemnifying  party will not relieve the indemnifying party from liability
      under  Paragraph (a) or (b), except to the extent the  indemnifying  party
      has  been  materially  prejudiced  by the  failure  to  give  notice.  The
      indemnifying  party will be entitled to  participate in the defense of any
      claim,  action,  suit or proceeding as to which  indemnification  is being
      sought,  and  if  the  indemnifying  party  acknowledges  in  writing  the
      obligation to indemnify the party against whom the claim,  action, suit or
      proceeding  is  brought,  the  indemnifying  party  may  (but  will not be
      required  to) assume  the  defense  against  the  claim,  action,  suit or
      proceeding with legal counsel chosen by the indemnifying  party.  After an
      indemnifying  party  notifies an indemnified  party that the  indemnifying
      party wishes to assume the defense of a claim,  action, suit or proceeding
      the indemnifying  party will not be liable for any legal or other expenses
      incurred by the  indemnified  party in connection with the defense against
      the claim,  action, suit or proceeding,  except that if, in the opinion of
      legal counsel to the  indemnifying  party,  one or more of the indemnified
      parties  should be  separately  represented  in  connection  with a claim,
      action,  suit or proceeding the  indemnifying  party will pay the fees and
      expenses  of one  separate  counsel  for  the  indemnified  parties.  Each
      indemnified party, as a condition  precedent to receiving  indemnification
      as provided in Paragraph (a) or (b),  will, at the cost and expense of the
      indemnifying  party,   cooperate  in  all  reasonable  respects  with  the
      indemnifying party in the defense of the claim, action, suit or proceeding
      as to which  indemnification  is  sought.  No  indemnifying  party will be
      liable  for any  settlement  of any  claim,  action,  suit  or  proceeding
      effected  without its prior written consent.  No indemnifying  party will,
      without the prior written  consent of the  indemnified  party,  effect any
      settlement of a pending or  threatened  claim,  action or proceeding  with
      respect which an indemnified party is, or is informed that it may be, made
      a party and for which it would be entitled to indemnification,  unless the
      settlement includes an unconditional release of the indemnified party from
      all  liability  and claims which are the subject  matter of the pending or
      threatened action.

                                     - 3 -

<PAGE>


(3)   CONTRIBUTION.  If for any reason the indemnification  provided for in this
      agreement is not available to, or is not sufficient to hold  harmless,  an
      indemnified party in respect of any loss, claim, damage,  liability,  cost
      or expense  referred to in Paragraph (a) or (b), each  indemnifying  party
      will, in lieu of  indemnifying  the indemnified  party,  contribute to the
      amount paid or payable by the  indemnified  party as a result of the loss,
      claim, damage,  liability,  cost or expense (i) in the proportion which is
      appropriate to reflect the relative  benefits received by the indemnifying
      party, on the one hand, and by the  indemnified  party, on the other hand,
      from the sale of stock which is the subject of the claim,  action, suit or
      proceeding which resulted in the loss, claim,  liability,  cost or expense
      or (ii) if that  allocation is not  permitted by  applicable  law, in such
      proportion as is appropriate to reflect not only the relative  benefits of
      the sale of stock, but also the relative fault of the  indemnifying  party
      and the  indemnified  party with  respect to the  statements  or omissions
      which are the  subject  of the  claim,  action,  suit or  proceeding  that
      resulted in the loss, claim, damage, liability, cost or expense as well as
      any other relevant equitable considerations.


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