CYTOGEN CORP
8-K, 2000-09-07
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                            -------------------------

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the

                         Securities Exchange Act of 1934

        Date of report (Date of earliest event reported): August 25, 2000
                                                          ---------------


                               CYTOGEN CORPORATION
                  -------------------------------------------
               (Exact Name of Registrant as Specified in Charter)

       Delaware                     000-14879                     22-2322400
       --------                     ---------                     ----------
(State or Other Jurisdiction       (Commission                (I.R.S. Employer
     of Incorporation)             File Number)              Identification No.)

600 College Road East, CN5308
       Princeton, NJ                                               08540-5308
  -------------------------                                        ----------
   (Address of Principal                                           (Zip Code)
    Executive Offices)



       Registrant's telephone number, including area code: (609) 750-8200
                                                          ----------------


--------------------------------------------------------------------------------
         (Former name or former address, if changed since last report.)


<PAGE>



ITEM 5. OTHER EVENTS.

     On  August  25,  2000,   Cytogen   Corporation   ("Cytogen"),   a  Delaware
corporation,  Cytogen  Acquisition  Corp., a Delaware  corporation  and a wholly
owned  subsidiary  of  Cytogen,   and  Advanced   Magnetics,   Inc.   ("Advanced
Magnetics"),  a Delaware  corporation,  terminated  their  Agreement and Plan of
Merger (the "Merger  Agreement")  dated as of July 7, 2000. In addition,  voting
agreements  by  and  between  certain   stockholders  of  Cytogen  and  Advanced
Magnetics,  pursuant to which such  stockholders  agreed to vote their shares in
favor of,  among other  things,  the  adoption of the Merger  Agreement  and the
approval of the merger,  terminated simultaneously therewith. Also on August 25,
2000,  Cytogen and Advanced  Magnetics entered into product marketing and supply
agreements that cover products in Advanced  Magnetics'  pipeline.  In connection
with such agreements,  Advanced  Magnetics  received  1,500,000 shares of common
stock of Cytogen  (300,000 of which are freely  tradeable  and the  remainder of
which will become freely  tradeable in increments of 300,000 on the 25th of each
of the four months  beginning  September  25,  2000) and an  additional  500,000
shares of common stock of Cytogen have been placed in escrow to be released upon
satisfaction of certain milestones. The press release announcing the termination
of the Merger  Agreement is attached  hereto as Exhibit 99.1 and is incorporated
herein by reference.

     Statements  contained  in this  Report on Form 8-K that are not  historical
facts may  constitute  "forward-looking  statements"  within the  meaning of the
Private Securities  Litigation Reform Act of 1995. These statements are based on
management's  current expectations and are subject to uncertainty and changes in
circumstances. Actual results may vary materially from the expectation contained
in the forward-looking  statements.  The following factors,  among others, could
cause  actual  results  to  differ   materially  from  those  described  in  the
forward-looking statements:  uncertainties as to FDA approval of Combidex(R) and
Code 7228 for marketing,  and other risks identified in Cytogen's Securities and
Exchange Commission filings.


<PAGE>


ITEM 7. EXHIBITS.

        (c)     Exhibits.
                --------

        Exhibit No.                            Description
        -----------                            -----------
           99.1               Press Release of Cytogen Corporation, dated August
                              28, 2000.





<PAGE>


                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly caused this current  report on Form 8-K to be signed on its
behalf by the undersigned hereunto duly authorized.

                                        CYTOGEN CORPORATION


                                        By: /s/ H. Joseph Reiser
                                           -------------------------------------
                                           H. Joseph Reiser, Ph.D.
                                           President and Chief Executive Officer

Dated:   September 1, 2000


<PAGE>


                                  EXHIBIT INDEX

Exhibit No.                                 Description
-----------                                 -----------

   99.1             Press Release of Cytogen Corporation, dated August 28, 2000.





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