CYTOGEN CORP
10-Q, EX-3.1, 2000-08-11
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                                     EXHIBIT 3.1

                            CERTIFICATE OF AMENDMENT
                                       TO
                    THE RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                               CYTOGEN CORPORATION


     CYTOGEN  CORPORATION,  a corporation  organized  and existing  under and by
virtue  of  the  General   Corporation   Law  of  the  State  of  Delaware  (the
"Corporation"), DOES HEREBY CERTIFY as follows:

     FIRST: That Article FIFTH of the Restated Certificate of Incorporation,  as
amended,  of the  Corporation  is hereby  amended to read, in its  entirety,  as
follows:

     "FIFTH:  A. Total Capital Stock.  The total number of shares of all classes
of capital  stock which the  Corporation  shall have  authority  to issue is TWO
HUNDRED FIFTY FIVE MILLION FOUR HUNDRED THOUSAND  (255,400,000) shares, of which
TWO HUNDRED FIFTY MILLION  (250,000,000)  shall be shares of Common Stock, $0.01
par value per share  ("Common  Stock"),  and FIVE MILLION FOUR HUNDRED  THOUSAND
(5,400,000)  shares  shall  be  Preferred  Stock,  $0.01  par  value  per  share
("Preferred Stock").

     B. Common Stock.  Each holder of Common Stock shall be entitled to one vote
for each share of Common  Stock held on all  matters on which  holders of Common
Stock shall be entitled to vote.

     C. Preferred Stock. The Board of Directors of the Corporation is authorized
to cause  the  Preferred  Stock to be issued  in one or more  series,  with such
voting powers, full or limited, or no voting powers, and with such designations,
preferences  and relative,  participating,  optional or other special rights and
qualifications,  limitations  or  restrictions  thereof,  as shall be stated and
expressed in the resolution or resolutions providing for the issue of such stock
adopted by the Board of Directors.  The Board of Directors of the Corporation is
expressly  authorized to adopt such  resolution or resolutions and to issue such
stock as may be desirable.

     D. Residual  Rights.  All rights accruing to the outstanding  shares of the
Corporation not expressly provided for to the contrary herein shall be vested in
the outstanding shares of Common Stock and Preferred Stock pari passu."

     SECOND:  That the  aforesaid  amendments  were duly adopted by the Board of
Directors and by the  stockholders  of the  Corporation  in accordance  with the
provisions  of  Section  242 of the  General  Corporation  Law of the  State  of
Delaware.



                                     *******



<PAGE>


     IN WITNESS  WHEREOF,  the  Corporation  has caused this  Certificate  to be
signed by its duly elected President on this 14th day of May, 2000.
                                             ----



                                           CYTOGEN CORPORATION


                                           By:  /s/ H. Joseph Reiser
                                           H. Joseph Reiser, Ph.D.
                                           President and Chief Executive Officer










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