CEL SCI CORP
S-8, 1998-06-25
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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   As filed with the  Securities  and Exchange  Commission  on June 24, 1998
Registration No.
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                    FORM S-8
                             REGISTRATION STATEMENT
                         UnderThe Securities Act of l933

                               CEL-SCI CORPORATION

                        (Exact name of issuer as specified in its charter)

       Colorado                                    84-0916344
 ----------------------------                    -------------------
 (State or other jurisdiction                    (I.R.S. Employer
  of incorporation or organization               Identification No.)

  8229 Boone Blvd., Suite 802
      Vienna, Virginia                                 22182
  ----------------------------                        --------
 (Address of Principal Executive Offices)            (Zip Code)

                          Incentive Stock Option Plans
                        Non-Qualified Stock Option Plans
                               Stock Bonus Plans
                        --------------------------------     
                               (Full Title of Plan)

                                Geert R. Kersten
                               CEL-SCI Corporation
                           8229 Boone Blvd., Suite 802
                              Vienna, Virginia 22182
                     -------------------------------------                    
                    (Name and address of agent for service)

                                (703) 506-9460
                 ------------------------------------------                  
        (Telephone number, including area code, of agent for service)

         Copies of all  communications,  including  all  communications  sent to
agent for service to:

                              William T. Hart, Esq.
                                 Hart & Trinen
                             l624 Washington Street
                             Denver, Colorado 80203
                                 (303) 839-0061

<PAGE>




                          CALCULATION OF REGISTRATION FEE
                                       Proposed        Proposed
Title of                                maximum        maximum
securities               Amount        offering       aggregate     Amount of
 to be                    to be          price        offering    registration
registered            registered (1)  per share (2)     price
- -----------------------------------------------------------------------------
      fee

Common Stock             300,000          $4.94      $1,482,000     $438
Issuable Pursuant
to Incentive Stock
Option Plan

Common Stock           1,400,000          $4.94      $6,916,000    $2,040
Issuable Pursuant
to Non-Qualified
Stock Option Plans

Common Stock Issuable    100,000          $4.94        $494,000     $146
Pursuant to Stock Bonus
Plans

                       ---------                     ----------    ------
                       1,800,000                     $8,892,000    $2,624
                       =========                     ==========    ======

- ------------------------------------------------------------------------------

(1) This  Registration  Statement also covers such additional  number of shares,
presently undeterminable, as may become issuable under the Plans in the event of
stock dividends, stock splits,  recapitalizations or other changes in the Common
Stock.  The shares  subject to this  Registration  Statement  reflect the shares
available for issuance pursuant to (i) options granted under the Incentive Stock
Option and Non-Qualified Stock Option Plans, and (ii) shares granted pursuant to
the Company's Stock Bonus Plans all of which may be reoffered in accordance with
the provisions of Form S-8.

(2) Varied, but not less than the fair market value on the date that the options
were or are granted.  Pursuant to Rule 457(g),  the  proposed  maximum  offering
price per share and proposed maximum aggregate offering price are based upon the
average bid and asked prices of the Registrant's Common Stock on June 23, 1998.



<PAGE>


                               CEL-SCI CORPORATION
              Cross Reference Sheet Required Pursuant to Rule 404
                                     PART 1
                       IINFORMATION REQUIRED IN PROSPECTUS
(NOTE: Pursuant to instructions to Form S-8, the Prospectus described below is 
                  not filed with this Registration Statement.)

Item
 No.     Form S-8 Caption                              Caption in Prospectus
- ----     -----------------                          --------------------------
  1.     Plan Information

         (a)  General Plan Information             Stock Option and Bonus Plans

         (b)  Securities to be Offered             Stock Option and Bonus Plans

         (c)  Employees who may Participate
              in the Plan                          Stock Option and Bonus Plans

         (d)  Purchase of Securities Pursuant
              to the Plan and Payment for
              Securities Offered                   Stock Option and Bonus Plans

         (e)  Resale Restrictions                 Resale of Shares by Affiliates

         (f)  Tax Effects of Plan
              Participation                        Stock Option and Bonus Plans

         (g)  Investment of Funds                  Not Applicable.

         (h)  Withdrawal from the Plan;
              Assignment of Interest               Other Information Regarding 
                                                   the Plans

         (i)  Forfeitures and Penalties            Other Information Regarding 
                                                   the Plans

         (j)  Charges and Deductions and
              Liens Therefore                      Other Information Regarding
                                                   the Plans

    2.   Registrant Information and Employee
         Plan Annual Information                   Available Information,
                                                   Documents Incorporated by
                                                   Reference


<PAGE>


                                     PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 3 - Incorporation of Documents by Reference
- ------------------------------------------------
The following  documents  filed by the Company with the  Securities and Exchange
Commission are incorporated by reference in this Registration Statement:  Annual
Report on Form l0-K for the year ending September 30, 1997,  report on Form 10-Q
for the quarter ending December 31, 1997, report on Form 10-Q for quarter ending
March 31, 1998 and Proxy Statement relating to the Company's May 29, 1998 Annual
Meeting of  Shareholders.  All reports and documents  subsequently  filed by the
Company pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange
Act  of  1934,  prior  to the  filing  of a  post-effective  amendment  to  this
Registration  Statement of which this  Prospectus is a part which indicates that
all securities offered hereby have been sold or which deregisters all securities
then remaining  unsold,  shall be deemed to be incorporated by reference in this
Prospectus  and to be a part  thereof from the date of filing of such reports or
documents.

Item 4 - Description of Securities
- -----------------------------------
         Not required.

Item 5 - Interests of Named Experts and Counsel
- ------------------------------------------------
         Not Applicable.

Item 6 - Indemnification of Directors and Officers
- ---------------------------------------------------
The Bylaws of the Company  provide in substance that the Company shall indemnify
any  person  who was or is a party  or is  threatened  to be made a party to any
threatened or completed  action,  suit or proceeding,  whether civil,  criminal,
administrative,  or  investigative  by reason of the fact that such person is or
was a director,  officer, employee,  fiduciary or agent of the Company, or is or
was  serving at the request of the  Company as a  director,  officer,  employee,
fiduciary or agent of another corporation,  partnership, joint venture, trust or
other enterprise, against expenses (including attorney's fees), judgments, fines
and amounts paid in settlement  actually and reasonably  incurred by such person
to the full  extent  permitted  by the laws of the state of  Colorado;  and that
expenses  incurred  in  defending  any such civil or  criminal  action,  suit or
proceeding  may be paid by the  Company in advance of the final  disposition  of
such action,  suit or  proceeding as authorized by the Board of Directors in the
specific case upon receipt of an  undertaking  by or on behalf of such director,
officer  or  employee  to repay  such  amount  to the  Company  unless  it shall
ultimately be determined  that such person is entitled to be  indemnified by the
Company as authorized in the Bylaws.

Item 7 - Exemption from Registration Claimed
- ---------------------------------------------
         None.
<PAGE>

Item  8  -   Exhibits  
- ---------------------
 4  -   Instruments  Defining  Rights
 of Security Holders

   (a) - Common Stock                       Incorporated   by   reference   to
                                          Exhibit   4(a)   of  the   Company's
                                          Registration   Statements   on  Form
                                          S-l,   File   Nos.   2-85547-D   and
                                          33-7531.

   (b) - 1996 Non-Qualified Stock Option Plan, ---------------------------------
        as amended

   (c) - 1998 Incentive Stock Option Plan     ----------------------------------

   (d) - 1998 Non-Qualified Stock Option Plan ----------------------------------

   (e) - 1998 Stock Bonus Plan                ----------------------------------

  5 - Opinion Regarding Legality              ----------------------------------

 l5 - Letter Regarding Unaudited Interim
       Financial Information                        None

 23 - Consent of Independent Public
        Accountants and Attorneys            ----------------------------------

 24 - Power of Attorney                     Included in the signature page
                                            of this Registration Statement

  99 - Additional Exhibits
    (Re-Offer Prospectus)                    ----------------------------------

Item 9 - Undertakings

         (a)  The undersigned registrant hereby undertakes:

              (1) To file,  during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:

                   (i)  to  include   any   prospectus   required  by  Section
                        l0(a)(3) of the Securities Act of l933;

                   (ii) to reflect in the prospectus any facts or events arising
                        after the effective date of the  registration  statement
                        (or the most recent  post-effective  amendment  thereof)
                        which,  individually  or in the  aggregate,  represent a
                        fundamental  change in the  information set forth in the
                        registration statement; and

                   (iii)to include any material  information with respect to the
                        plan of  distribution  not  previously  disclosed in the
                        registration  statement or any  material  change in such
                        information in the registration statement;

                        Provided,   however,   that  paragraphs   (a)(l)(i)  and
                        (a)(l)(ii) will not apply if the information required to
                        be  included  in a  post-effective  amendment  by  those
                        paragraphs is contained in periodic reports filed by the
                        registrant  pursuant  to Section l3 or Section  l5(d) of
                        the Securities Act of l934

              (2) That, for the purpose of determining  any liability  under the
Securities Act of l933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

              (3) To  remove  from  registration  by means  of a  post-effective
amendment  any of the  securities  being  registered  which remain unsold at the
termination of the offering.

         (b) The undersigned  registrant hereby undertakes that, for purposes of
determining  any liability  under the Securities Act of l933, each filing of the
registrant's  Annual  Report  pursuant to Section  l3(a) or Section l5(d) of the
Securities  Exchange  Act of l934 (and,  where  applicable,  each  filing of any
employee  benefit  plan's  annual  report  pursuant  to  Section  l5(d)  of  the
Securities  Exchange  Act of l934)  that is  incorporated  by  reference  in the
registration  statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         (c)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities Act of 1933 may be permitted to directors,  officers and  controlling
persons of the registrant  pursuant to the foregoing  provisions,  or otherwise,
the  registrant  has been  advised  that in the  opinion of the  Securities  and
Exchange  Commission such  indemnification is against public policy as expressed
in the Act and is,  therefore,  unenforceable.  In the  event  that a claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.



<PAGE>


                                 POWER OF ATTORNEY
                     KNOW  ALL  MEN  BY  THESE  PRESENTS,  that  each  of  the
undersigned  constitutes and appoints  Maximilian de Clara and Geert R. Kersten,
and each of them, his true and lawful  attorneys-in-fact  and agents,  with full
power of substitution  and  resubstitution,  for him and in his name,  place and
stead,  in any and all  capacities,  to sign any and all  amendments  (including
post-effective amendments) to this Registration Statement, and to file the same,
with all exhibits thereto, and all other documents in connection therewith, with
the Securities and Exchange Commission granting unto said  attorneys-in-fact and
agents full power and  authority  to do and perform each and every act and thing
requisite  and  necessary to be done, as fully to all intents and purposes as he
might or could do in  person,  hereby  ratifying  and  confirming  all that said
attorneys-in-fact  and agents or their substitutes or substitute may lawfully do
or cause to be done by virtue hereof.

                                  SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  l933,  the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Alexandria, State of Virginia, on June 23, 1998.

                               CEL-SCI CORPORATION

                                       By:     /s/ Maximilian de Clara
                                          --------------------------------
                                          MAXIMILIAN DE CLARA, PRESIDENT

         Pursuant  to the  requirements  of the  Securities  Act of  l933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

Signature                            Title                      Date

/s/ Maximilian de Clara        Director and President        June 23, 1998
- ------------------------
 MAXIMILIAN DE CLARA                     



/s/ Geert R. Kersten           Director,Principal            June 23, 1998
- --------------------           Financial Officer and
GEERT R. KERSTEN               Chief Executive Officer
                              

- --------------------           Director                      June 23, l998
MARK V. SORESI

/s/ Donald Hudson              Director                      June 23, 1998
- --------------------
F. DONALD HUDSON



<PAGE>

                                    FORM S-8
                              CEL-SCI Corporation
                                8229 Boone Blvd.
                                    Suite 802
                             Vienna, Virginia 22182


                                   EXHIBITS

<PAGE>

Exhibits 
- --------

  4   -   Instruments Defining Rights of
          Security Holders

  (a) -   Common Stock                          Incorporated by  reference   to
                                                Exhibit 4(a) of the Company's
                                                Registration Statements on Form
                                                S-l, File Nos. 2-85547-D and
                                                33-7531.

   (b) - 1996 Non-Qualified Stock Option Plan,  --------------------------------
         as amended

   (c) - 1998 Incentive Stock Option Plan       --------------------------------

   (d) - 1998 Non-Qualified Stock Option Plan   --------------------------------

   (e) - 1998 Stock Bonus Plan                  --------------------------------

  5 - Opinion Regarding Legality                --------------------------------

 l5 - Letter Regarding Unaudited Interim
      Financial Information                      None

 23 - Consent of Independent Public
        Accountants and Attorneys               --------------------------------

 24 - Power of Attorney                          Included in the signature page
                                                 of this Registration Statement

99 - Additional Exhibits
      (Re-Offer Prospectus)                     --------------------------------



<PAGE>


                                 EXHIBIT 4(b)

<PAGE>


                             CEL-SCI CORPORATION
                     1996 NON-QUALIFIED STOCK OPTION PLAN
                                 (As amended)


         1. Purpose.  This 1996 Non-Qualified  Stock Option Plan (the "Plan") is
intended to advance the interests of CEL-SCI Corporation (the "Company") and its
shareholders,   by  encouraging  and  enabling  selected  officers,   directors,
consultants  and key employees  upon whose  judgment,  initiative and effort the
Company is largely  dependent for the  successful  conduct of its  business,  to
acquire and retain a  proprietary  interest in the Company by  ownership  of its
stock.  Options  granted  under the Plan are intended to be Options which do not
meet the  requirements  of Section 422 of the Internal  Revenue Code of l954, as
amended (the "Code").

         2.   Definitions.

         (a)  "Board" means the Board of Directors of the Company.

         (b)  "Committee"  means the directors  duly appointed to administer the
Plan.

         (c)  "Common Stock" means the Company's Common Stock.

         (d) "Date of Grant" means the date on which an Option is granted under 
the Plan.

         (e) "Option" means an Option granted under the Plan.

         (f) "Optionee" means a person to whom an Option, which has not expired,
has been granted under the Plan.

         (g)  "Successor"  means the  legal  representative  of the  estate of a
deceased  optionee or the person or persons who acquire the right to exercise an
Option by bequest or inheritance or by reason of the death of any Optionee.

         3.  Administration  of Plan.  The Plan  shall  be  administered  by the
Company's  Board of  Directors or in the  alternative,  by a committee of two or
more directors  appointed by the Board (the "Committee").  If a Committee should
be appointed,  the  Committee  shall report all action taken by it to the Board.
The Committee shall have full and final authority in its discretion,  subject to
the provisions of the Plan, to determine the individuals to whom and the time or
times at which  Options  shall be granted and the number of shares and  purchase
price of Common Stock  covered by each Option;  to construe  and  interpret  the
Plan; to determine the terms and provisions of the respective Option agreements,
which need not be identical,  including, but without limitation,  terms covering
the payment of the Option Price; and to make all other  determinations  and take
all other actions deemed necessary or advisable for the proper administration of
the Plan. All such actions and determinations  shall be conclusively binding for
all purposes and upon all persons.

         4. Common Stock Subject to Options.  The aggregate  number of shares of
the  Company's  Common  Stock which may be issued  upon the  exercise of Options
granted under the Plan shall not exceed  1,500,000,  subject to adjustment under
the  provisions of paragraph 7. The shares of Common Stock to be issued upon the
exercise of Options may be  authorized  but unissued  shares,  shares issued and
reacquired by the Company or shares bought on the market for the purposes of the
Plan. In the event any Option shall,  for any reason,  terminate or expire or be
surrendered  without  having been  exercised in full, the shares subject to such
Option but not purchased  thereunder  shall again be available for Options to be
granted under the Plan.

         5.  Participants.  Options may be granted  under the Plan the Company's
employees,  directors and officers,  and consultants or advisors to the Company,
provided  however that bona fide services shall be rendered by such  consultants
or advisors and such services  must not be in connection  with the offer or sale
of securities in a capital-raising transaction.

         6. Terms and  Conditions of Options.  Any Option granted under the Plan
shall be evidenced by an agreement executed by the Company and the recipient and
shall  contain such terms and be in such form as the  Committee may from time to
time approve, subject to the following limitations and conditions:

              (a) Option Price.  The Option Price per share with respect to each
Option shall be  determined  by the  Committee  but shall in no instance be less
than the market value of the Common Stock.

              (b) Period of Option.  The period  during which each option may be
exercised,  and the  expiration  date of  each  Option  shall  be  fixed  by the
Committee,  but, notwithstanding any provision of the Plan to the contrary, such
expiration date shall not be more than ten years from the date of Grant.

              (c) Vesting of  Shareholder  Rights.  Neither an Optionee  nor his
successor  shall  have any  rights as a  shareholder  of the  Company  until the
certificates  evidencing  the shares  purchased  are properly  delivered to such
Optionee or his successor.

              (d) Exercise of Option. Each Option shall be exercisable from time
to time during a period (or periods) determined by the Committee and ending upon
the expiration or termination of the Option;  provided,  however,  the Committee
may,  by the  provisions  of any  Option  Agreement,  limit the number of shares
purchasable  thereunder in any period or periods of time during which the Option
is exercisable.

              (e)  Nontransferability of Option. No Option shall be transferable
or assignable by an Optionee,  otherwise than by will or the laws of descent and
distribution  and  each  Option  shall be  exercisable,  during  the  Optionee's
lifetime, only by him. No Option shall be pledged or hypothecated in any way and
no Option shall be subject to execution,  attachment,  or similar process except
with the express consent of the Committee.

              (f) Death of Optionee. If an Optionee dies while holding an Option
granted  hereunder,  his Option  privileges shall be limited to the shares which
were  immediately  purchasable  by him at the  date of  death  and  such  Option
privileges  shall expire unless  exercised by his  successor  within four months
after the date of death.

         7.  Reclassification,  Consolidation,  or Merger.  If and to the extent
that the number of issued  shares of Common  Stock of the  Corporation  shall be
increased  or  reduced  by change  in par  value,  split  up,  reclassification,
distribution  of a dividend  payable in stock, or the like, the number of shares
subject  to Option  and the  Option  price per  share  shall be  proportionately
adjusted by the  Committee,  whose  determination  shall be  conclusive.  If the
Corporation is reorganized or consolidated  or merged with another  corporation,
an Optionee  granted an Option  hereunder  shall be entitled to receive  Options
covering shares of such reorganized, consolidated, or merged company in the same
proportion, at an equivalent price, and subject to the same conditions.  The new
Option  or  assumption  of the old  Option  shall not give  Optionee  additional
benefits which he did not have under the old Option,  or deprive him of benefits
which he had under the old Option.

         8. Restrictions on Issuing Shares. The exercise of each Option shall be
subject to the condition that if at any time the Company shall  determine in its
discretion  that  the  satisfaction  of  withholding  tax or  other  withholding
liabilities, or that the listing,  registration,  or qualification of any shares
otherwise  deliverable upon such exercise upon any securities  exchange or under
any state or federal  law, or that the  consent or  approval  of any  regulatory
body, is necessary or desirable as a condition of, or in connection  with,  such
exercise or the delivery or purchase of shares  purchased  thereto,  then in any
such event,  such  exercise  shall not be  effective  unless  such  withholding,
listing,  registration,  qualification,  consent,  or  approval  shall have been
effected or obtained free of any conditions not acceptable to the Company.

Unless the shares of stock  covered  by the Plan have been  registered  with the
Securities and Exchange  Commission  pursuant to Section 5 of the Securities Act
of l933, each optionee shall, by accepting an option,  represent and agree,  for
himself and his  transferees  by will or the laws of descent  and  distribution,
that all shares of stock  purchased  upon the  exercise  of the  option  will be
acquired for investment and not for resale or  distribution.  Upon such exercise
of any portion of an option,  the person  entitled  to exercise  the same shall,
upon  request of the  Company,  furnish  evidence  satisfactory  to the  Company
(including a written and signed representation) to the effect that the shares of
stock are being  acquired  in good  faith for  investment  and not for resale or
distribution.  Furthermore,  the Company may, if it deems  appropriate,  affix a
legend to certificates  representing  shares of stock purchased upon exercise of
options indicating that such shares have not been registered with the Securities
and Exchange  Commission and may so notify the Company's  transfer  agent.  Such
shares may be  disposed  of by an optionee in the  following  manner  only:  (l)
pursuant to an effective registration statement covering such resale or reoffer,
(2) pursuant to an  applicable  exemption  from  registration  as indicated in a
written  opinion of counsel  acceptable to the Company,  or (3) in a transaction
that  meets all the  requirements  of Rule l44 of the  Securities  and  Exchange
Commission. If shares of stock covered by the Plan have been registered with the
Securities and Exchange Commission,  no such restrictions on resale shall apply,
except  in the case of  optionees  who are  directors,  officers,  or  principal
shareholders  of the Company.  Such persons may dispose of shares only by one of
the three aforesaid methods.

         9. Use of Proceeds.  The proceeds received by the Company from the sale
of Common Stock pursuant to the exercise of Options granted under the Plan shall
be added to the Company's general funds and used for general corporate purposes.

         l0.  Amendment,  Suspension,  and  Termination  of Plan.  The  Board of
Directors may alter,  suspend, or discontinue the Plan, but may not, without the
approval of a majority of those holders of the Company's  Common Stock voting in
person  or by proxy  at any  meeting  of the  Company's  shareholders,  make any
alteration  or amendment  thereof which  operates to (a) abolish the  Committee,
change the qualification of its members,  or withdraw the  administration of the
Plan from its supervision, (b) make any material change in the class of eligible
employees  as defined in  paragraph  5, (c)  increase the total number of shares
reserved  for  purposes  of this Plan except as  provided  in  paragraph  7, (d)
increase  the  total  number of shares  for  which an option or  options  may be
granted to any one  employee,  (e)  extend  the term of the Plan or the  maximum
option  periods  provided in paragraph 6, (f) decrease the minimum  option price
provided in paragraph  6, except as provided in  paragraph 7, or (g)  materially
increase the benefits accruing to employees participating under this Plan.

         Unless the Plan shall  theretofore  have been  terminated by the Board,
the Plan shall  terminate  ten years after the  effective  date of the Plan.  No
Option may be granted  during any  suspension  or after the  termination  of the
Plan. No amendment,  suspension,  or termination  of the Plan shall,  without an
Optionee's  consent,  alter or impair any of the rights or obligations under any
Option theretofore granted to such Optionee under the Plan.

         11.  Limitations.  Every right of action by or on behalf of the Company
or by any shareholder  against any past,  present or future member of the Board,
or any officer or employee of the Company  arising out of or in connection  with
this Plan shall,  irrespective of the place where such action may be brought and
irrespective of the place of residence of any such director, officer or employee
cease and be barred by the expiration of one year from whichever is the later of
(a) the date of the act or  omission  in  respect  of which such right of action
arises; or (b) the first date upon which there has been made generally available
to  shareholders  an annual report of the Company or any proxy statement for the
annual  meeting of  shareholders  following the issuance of such annual  report,
which annual  report and proxy  statement  alone or together set forth,  for the
related  period,  the number of shares issuable upon the exercise of the options
granted  pursuant to this Plan;  and any and all right of action by any employee
(past,  present or future)  against the Company  arising out of or in connection
with  this Plan  shall,  irrespective  of the place  where  such  action  may be
brought,  cease and be barred by the expiration of one year from the date of the
act or omission in respect of which such right of action arises.

         l2.  Governing  Law.  The Plan shall be  governed  by the laws of the
State of Colorado.

         l3.  Expenses of  Administration.  All costs and expenses incurred in
the operation and administration of this Plan shall be borne by the Company.

                                  CEL-SCI CORPORATION



                                  By------------------------


<PAGE>


                                 EXHIBIT 4(c)

<PAGE>


                             CEL-SCI CORPORATION
                       1998 INCENTIVE STOCK OPTION PLAN



         l. Purpose.  The purpose of the 1998  Incentive  Stock Option Plan (the
"Plan") is to advance the interests of CEL-SCI  Corporation  and any  subsidiary
corporation   (hereinafter  referred  to  as  the  "Company")  and  all  of  its
shareholders,  by strengthening  the Company's  ability to attract and retain in
its employ  individuals  of training,  experience,  and ability,  and to furnish
additional  incentive  to officers  and valued  employees  upon whose  judgment,
initiative,  and efforts the successful  conduct and development of its business
largely depends,  by encouraging such officers and employees to become owners of
capital stock of the Company.

              This will be  effected  through the  granting of stock  options as
herein  provided,  which  options are  intended to qualify as  "Incentive  Stock
Options"  within the meaning of Section 422 of the  Internal  Revenue  Code,  as
amended (the "Code").

         2.   Definitions.

         (a)  "Board" means the Board of Directors of the Company.

         (b)  "Committee"  means the directors  duly appointed to administer the
Plan.

         (c)  "Common Stock" means the Company's Common Stock.

         (d) "Date of Grant" means the date on which an Option is granted  under
the Plan.

         (e) "Option" means an Option granted under the Plan.

         (f) "Optionee" means a person to whom an Option, which has not expired,
has been granted under the Plan.

         (g)  "Successor"  means the  legal  representative  of the  estate of a
deceased  optionee or the person or persons who acquire the right to exercise an
Option by bequest or inheritance or by reason of the death of any Optionee.

         3.  Administration  of Plan.  The Plan  shall  be  administered  by the
Company's  Board of  Directors or in the  alternative,  by a committee of two or
more directors  appointed by the Board (the "Committee").  If a Committee should
be appointed,  the  Committee  shall report all action taken by it to the Board.
The Committee shall have full and final authority in its discretion,  subject to
the provisions of the Plan, to determine the individuals to whom and the time or
times at which  Options  shall be granted and the number of shares and  purchase
price of Common Stock  covered by each Option;  to construe  and  interpret  the
Plan; to determine the terms and provisions of the respective Option agreements,
which need not be identical,  including, but without limitation,  terms covering
the payment of the Option Price; and to make all other  determinations  and take
all other actions deemed necessary or advisable for the proper administration of
the Plan. All such actions and determinations  shall be conclusively binding for
all purposes and upon all persons.

         4. Common Stock Subject to Options.  The aggregate  number of shares of
the  Company's  Common  Stock which may be issued  upon the  exercise of Options
granted under the Plan shall not exceed 300,000, subject to adjustment under the
provisions  of  paragraph  9. The shares of Common  Stock to be issued  upon the
exercise of Options may be  authorized  but unissued  shares,  shares issued and
reacquired by the Company or shares bought on the market for the purposes of the
Plan. In the event any Option shall,  for any reason,  terminate or expire or be
surrendered  without  having been  exercised in full, the shares subject to such
Option but not purchased  thereunder  shall again be available for Options to be
granted under the Plan.

              The  aggregate  fair market value  (determined  as of the time any
option is granted) of the stock for which any  employee  may be granted  options
which are first exercisable in any single calendar year under this Plan (and any
other plan of the Company  meeting the  requirements  for Incentive Stock Option
Plans) shall not exceed $100,000.

         5.  Participants.  Options  will be  granted  only to  persons  who are
employees  of the  Company  and  only  in  connection  with  any  such  person's
employment.  The  term  "employees"  shall  include  officers  as well as  other
employees,  and the  officers  and  other  employees  who are  directors  of the
Company.  The Committee will  determine the employees to be granted  options and
the number of shares subject to each option.

         6. Terms and  Conditions of Options.  Any Option granted under the Plan
shall be evidenced by an agreement executed by the Company and the recipient and
shall  contain such terms and be in such form as the  Committee may from time to
time approve, subject to the following limitations and conditions:

              (a) Option Price.  The purchase  price of each option shall not be
less than l00% of the fair market  value of the  Company's  common  stock at the
time of the granting of the option provided,  however,  if the optionee,  at the
time the option is  granted,  owns stock  possessing  more than l0% of the total
combined voting power of all classes of stock of the Company, the purchase price
of the option  shall not be less than ll0% of the fair market value of the stock
at the time of the granting of the option.

              (b) Period of Option.  The maximum period for exercising an option
shall be l0 years  from the date upon  which the  option is  granted,  provided,
however,  if the  optionee,  at the time  the  option  is  granted,  owns  stock
possessing  more than l0% of the total  combined  voting power of all classes of
stock of the Company,  the maximum period for exercising an option shall be five
years  from the date upon  which the option is  granted  and  provided  further,
however, that these periods may be shortened in accordance with the pro- visions
of Paragraphs 6 or 7 below.

              Subject to the foregoing,  the period during which each option may
be  exercised,  and the  expiration  date of each  Option  shall be fixed by the
Committee.

              (c) Vesting of  Shareholder  Rights.  Neither an Optionee  nor his
successor  shall  have any  rights as a  shareholder  of the  Company  until the
certificates  evidencing  the shares  purchased  are properly  delivered to such
Optionee or his successor.

              (d) Exercise of Option. Each Option shall be exercisable from time
to time during a period (or periods) determined by the Committee and ending upon
the expiration or termination of the Option;  provided,  however,  the Committee
may,  by the  provisions  of any  Option  Agreement,  limit the number of shares
purchasable  thereunder in any period or periods of time during which the Option
is exercisable.  An Option shall not be exercisable in whole or in part prior to
the date of shareholder approval of the Plan.

              Options  may be  exercised  in part from time to time  during  the
option period.  The exercise of any option will be contingent upon compliance by
the Optionee (or purchaser  acting pursuant to Section 6(b)) with the provisions
of  Section  10 below and upon  receipt  by the  Company  of either  (i) cash or
certified bank check payable to its order in the amount of the purchase price of
such shares (ii) shares of Company stock having a fair market value equal to the
purchase  price of such shares,  or (iii) a combination  of (i) and (ii). If any
law or  regulation  requires  the Company to take any action with respect to the
shares to be issued upon  exercise of any option,  then the date for delivery of
such stock shall be extended for the period necessary to take such action.

              (e)  Nontransferability of Option. No Option shall be transferable
or  assignable by an Optionee,  otherwise  than by will or the laws of de- scent
and  distribution  and each Option shall be  exercisable,  during the Optionee's
lifetime, only by him. No Option shall be pledged or hypothecated in any way and
no Option shall be subject to execution,  attachment,  or similar process except
with the express consent of the Committee.

              (f) Death of  Optionee.  In the event of the death of an  optionee
while in the employ of the Company,  the option theretofore granted to him shall
be exercisable only within the three months  succeeding such death and then only
(i) by the  person or  persons to whom the  optionee's  rights  under the option
shall pass by the  optionee's  will or by the laws of descent and  distribution,
and (ii) if and to the extent that he was entitled to exercise the option at the
date of his death.

         7. Assumed Options. In connection with any transaction to which Section
424(a) of the Code is  applicable,  options  may be granted  pursuant  hereto in
substitution  of  existing  options  or  existing  options  may  be  assumed  as
prescribed   by  that   Section   and   any   regulations   issued   thereunder.
Notwithstanding anything to the contrary contained in this Plan, options granted
pursuant  to this  Paragraph  shall be at prices and shall  contain  such terms,
provisions,  and  conditions  as may be  determined  by the  Committee and shall
include  such  provisions  and  conditions  as  may be  necessary  to  meet  the
requirements of Section 424(a) of the Code.

         8. Certain Dispositions of Shares. Any options granted pursuant to this
Plan shall be  conditioned  such that if, within the earlier of (i) the two-year
period  beginning on the date of grant of an option or (ii) the one-year  period
beginning  on the date  after  which  any  share of stock is  transferred  to an
individual  pursuant to his exercise of an option,  such an  individual  makes a
disposition of such share of stock by way of sale,  exchange,  gift, transfer of
legal  title,  or  otherwise,   such  individual   shall  promptly  report  such
disposition  to the  Company in writing and shall  furnish to the  Company  such
details concerning such disposition as the Company may reasonably request.

         9.  Reclassification,  Consolidation,  or Merger.  If and to the extent
that the number of issued  shares of Common  Stock of the  Corporation  shall be
increased  or  reduced  by change  in par  value,  split  up,  reclassification,
distribution  of a dividend  payable in stock, or the like, the number of shares
subject  to Option  and the  Option  price per  share  shall be  proportionately
adjusted by the  Committee,  whose  determination  shall be  conclusive.  If the
Corporation is reorganized or consolidated  or merged with another  corporation,
an Optionee  granted an Option  hereunder  shall be entitled to receive  Options
covering shares of such reorganized, consolidated, or merged company in the same
proportion, at an equivalent price, and subject to the same conditions.  The new
Option  or  assumption  of the old  Option  shall not give  Optionee  additional
benefits which he did not have under the old Option,  or deprive him of benefits
which he had under the old Option.

         10.  Restrictions on Issuing Shares.  The exercise of each Option shall
be subject to the condition  that if at any time the Company shall  determine in
its discretion that the  satisfaction  of withholding  tax or other  withholding
liabilities, or that the listing,  registration,  or qualification of any shares
otherwise  deliverable upon such exercise upon any securities  exchange or under
any state or federal  law, or that the  consent or  approval  of any  regulatory
body, is necessary or desirable as a condition of, or in connection  with,  such
exercise or the delivery or purchase of shares  purchased  thereto,  then in any
such event,  such  exercise  shall not be  effective  unless  such  withholding,
listing,  registration,  qualification,  consent,  or  approval  shall have been
effected or obtained free of any conditions not acceptable to the Company.

         Unless  the shares of stock  covered  by the Plan have been  registered
with the  Securities  and  Exchange  Commission  pursuant  to  Section  5 of the
Securities Act of l933, each optionee  shall, by accepting an option,  represent
and agree,  for himself and his  transferees  by will or the laws of descent and
distribution, that all shares of stock purchased upon the exercise of the option
will be acquired for  investment and not for resale or  distribution.  Upon such
exercise of any portion of an option,  the person  entitled to exercise the same
shall, upon request of the Company, furnish evidence satisfactory to the Company
(including a written and signed representation) to the effect that the shares of
stock are being  acquired  in good  faith for  investment  and not for resale or
distribution.  Furthermore,  the Company may, if it deems  appropriate,  affix a
legend to certificates  representing  shares of stock purchased upon exercise of
options indicating that such shares have not been registered with the Securities
and Exchange Commission and may so notify its transfer agent. Such shares may be
disposed of by an optionee in the  following  manner  only:  (l)  pursuant to an
effective  registration  statement covering such resale or reoffer, (2) pursuant
to an applicable  exemption from  registration as indicated in a written opinion
of counsel acceptable to the Company, or (3) in a transaction that meets all the
requirements of Rule l44 of the Securities and Exchange Commission. If shares of
stock covered by the Plan have been  registered with the Securities and Exchange
Commission,  no such  restrictions on resale shall apply,  except in the case of
optionees who are directors, officers, or principal shareholders of the Company.
Such persons may dispose of shares only by one of the three aforesaid methods.

         11. Use of Proceeds. The proceeds received by the Company from the sale
of Common Stock pursuant to the exercise of Options granted under the Plan shall
be added to the Company's general funds and used for general corporate purposes.

         l2.  Amendment,  Suspension,  and  Termination  of Plan.  The  Board of
Directors may alter,  suspend, or discontinue the Plan, but may not, without the
approval of a majority of those holders of the Company's  Common Stock voting in
person  or by proxy  at any  meeting  of the  Company's  shareholders,  make any
alteration  or amendment  thereof which  operates to (a) abolish the  Committee,
change the qualification of its members,  or withdraw the  administration of the
Plan from its supervision, (b) make any material change in the class of eligible
employees  as  defined in Section  5, (c)  increase  the total  number of shares
reserved for purposes of this Plan except as provided in Section 9, (d) increase
the total  number of shares for which an option or options may be granted to any
one  employee,  (e) extend the term of the Plan or the  maximum  option  periods
provided in  paragraph 6, (f)  decrease  the minimum  option  price  provided in
paragraph 6, except as provided in paragraph 9, or (g)  materially  increase the
benefits accruing to employees participating under this Plan.

         Unless the Plan shall  theretofore  have been  terminated by the Board,
the Plan shall  terminate  ten years after the  effective  date of the Plan.  No
Option may be granted  during any  suspension  or after the  termination  of the
Plan. No amendment,  suspension,  or termination  of the Plan shall,  without an
Optionee's  consent,  alter or impair any of the rights or obligations under any
Option theretofore granted to such Optionee under the Plan.

         13.  Limitations.  Every right of action by or on behalf of the Company
or by any shareholder  against any past,  present or future member of the Board,
or any officer or employee of the Company  arising out of or in connection  with
this Plan shall,  irrespective of the place where such action may be brought and
irrespective of the place of residence of any such director, officer or employee
cease and be barred by the expiration of one year from whichever is the later of
(a) the date of the act or  omission  in  respect  of which such right of action
arises; or (b) the first date upon which there has been made generally available
to  shareholders  an annual report of the Company or any proxy statement for the
annual  meeting of  shareholders  following the issuance of such annual  report,
which annual  report and proxy  statement  alone or together set forth,  for the
related  period,  the number of shares issuable upon the exercise of the options
granted  pursuant to this Plan;  and any and all right of action by any employee
(past,  present or future)  against the Company  arising out of or in connection
with  this Plan  shall,  irrespective  of the place  where  such  action  may be
brought,  cease and be barred by the expiration of one year from the date of the
act or omission in respect of which such right of action arises.

         l4.  Effective Date of the Plan.

         This Plan shall become effective upon the adoption thereof by the Board
of Directors of the Company.

         l5.  Governing  Law.  The Plan shall be  governed  by the laws of the
State of Colorado.

         l6.  Expenses of  Administration.  All costs and expenses incurred in
the operation and administration of this Plan shall be borne by the Company.


                                  CEL-SCI CORPORATION


                                  By-------------------------




<PAGE>


                                 EXHIBIT 4(d)

<PAGE>


                             CEL-SCI CORPORATION
                     1998 NON-QUALIFIED STOCK OPTION PLAN



         1. Purpose.  This 1998 Non-Qualified  Stock Option Plan (the "Plan") is
intended to advance the interests of CEL-SCI Corporation (the "Company") and its
shareholders,   by  encouraging  and  enabling  selected  officers,   directors,
consultants  and key employees  upon whose  judgment,  initiative and effort the
Company is largely  dependent for the  successful  conduct of its  business,  to
acquire and retain a  proprietary  interest in the Company by  ownership  of its
stock.  Options  granted  under the Plan are intended to be Options which do not
meet the  requirements  of Section 422 of the Internal  Revenue Code of l954, as
amended (the "Code").

         2.   Definitions.

         (a)  "Board" means the Board of Directors of the Company.

         (b)  "Committee"  means the directors  duly appointed to administer the
Plan.

         (c)  "Common Stock" means the Company's Common Stock.

         (d) "Date of Grant" means the date on which an Option is granted  under
the Plan.

         (e) "Option" means an Option granted under the Plan.

         (f) "Optionee" means a person to whom an Option, which has not expired,
has been granted under the Plan.

         (g)  "Successor"  means the  legal  representative  of the  estate of a
deceased  optionee or the person or persons who acquire the right to exercise an
Option by bequest or inheritance or by reason of the death of any Optionee.

         3.  Administration  of Plan.  The Plan  shall  be  administered  by the
Company's  Board of  Directors or in the  alternative,  by a committee of two or
more directors  appointed by the Board (the "Committee").  If a Committee should
be appointed,  the  Committee  shall report all action taken by it to the Board.
The Committee shall have full and final authority in its discretion,  subject to
the provisions of the Plan, to determine the individuals to whom and the time or
times at which  Options  shall be granted and the number of shares and  purchase
price of Common Stock  covered by each Option;  to construe  and  interpret  the
Plan; to determine the terms and provisions of the respective Option agreements,
which need not be identical,  including, but without limitation,  terms covering
the payment of the Option Price; and to make all other  determinations  and take
all other actions deemed necessary or advisable for the proper administration of
the Plan. All such actions and determinations  shall be conclusively binding for
all purposes and upon all persons.

         4. Common Stock Subject to Options.  The aggregate  number of shares of
the  Company's  Common  Stock which may be issued  upon the  exercise of Options
granted under the Plan shall not exceed 300,000, subject to adjustment under the
provisions  of  paragraph  7. The shares of Common  Stock to be issued  upon the
exercise of Options may be  authorized  but unissued  shares,  shares issued and
reacquired by the Company or shares bought on the market for the purposes of the
Plan. In the event any Option shall,  for any reason,  terminate or expire or be
surrendered  without  having been  exercised in full, the shares subject to such
Option but not purchased  thereunder  shall again be available for Options to be
granted under the Plan.

         5.  Participants.  Options may be granted  under the Plan the Company's
employees,  directors and officers,  and consultants or advisors to the Company,
provided  however that bona fide services shall be rendered by such  consultants
or advisors and such services  must not be in connection  with the offer or sale
of securities in a capital-raising transaction.

         6. Terms and  Conditions of Options.  Any Option granted under the Plan
shall be evidenced by an agreement executed by the Company and the recipient and
shall  contain such terms and be in such form as the  Committee may from time to
time approve, subject to the following limitations and conditions:

              (a) Option Price.  The Option Price per share with respect to each
Option shall be  determined  by the  Committee  but shall in no instance be less
than the par value of the Common Stock.

              (b) Period of Option.  The period  during which each option may be
exercised,  and the  expiration  date of  each  Option  shall  be  fixed  by the
Committee,  but, notwithstanding any provision of the Plan to the contrary, such
expiration date shall not be more than ten years from the date of Grant.

              (c) Vesting of  Shareholder  Rights.  Neither an Optionee  nor his
successor  shall  have any  rights as a  shareholder  of the  Company  until the
certificates  evidencing  the shares  purchased  are properly  delivered to such
Optionee or his successor.

              (d) Exercise of Option. Each Option shall be exercisable from time
to time during a period (or periods) determined by the Committee and ending upon
the expiration or termination of the Option;  provided,  however,  the Committee
may,  by the  provisions  of any  Option  Agreement,  limit the number of shares
purchasable  thereunder in any period or periods of time during which the Option
is exercisable.

              (e)  Nontransferability  of Option.  No Option  shall be transfer-
able or assignable by an Optionee, otherwise than by will or the laws of descent
and  distribution  and each Option shall be  exercisable,  during the Optionee's
lifetime, only by him. No Option shall be pledged or hypothecated in any way and
no Option shall be subject to execution,  attachment,  or similar process except
with the express consent of the Committee.

              (f) Death of Optionee. If an Optionee dies while holding an Option
granted  hereunder,  his Option  privileges shall be limited to the shares which
were  immediately  purchasable  by him at the  date of  death  and  such  Option
privileges  shall expire unless  exercised by his  successor  within four months
after the date of death.

         7.  Reclassification,  Consolidation,  or Merger.  If and to the extent
that the number of issued  shares of Common  Stock of the  Corporation  shall be
increased  or  reduced  by change  in par  value,  split  up,  reclassification,
distribution  of a dividend  payable in stock, or the like, the number of shares
subject  to Option  and the  Option  price per  share  shall be  proportionately
adjusted by the  Committee,  whose  determination  shall be  conclusive.  If the
Corporation is reorganized or consolidated  or merged with another  corporation,
an Optionee  granted an Option  hereunder  shall be entitled to receive  Options
covering shares of such reorganized, consolidated, or merged company in the same
proportion, at an equivalent price, and subject to the same conditions.  The new
Option  or  assumption  of the old  Option  shall not give  Optionee  additional
benefits which he did not have under the old Option,  or deprive him of benefits
which he had under the old Option.

         8. Restrictions on Issuing Shares. The exercise of each Option shall be
subject to the condition that if at any time the Company shall  determine in its
discretion  that  the  satisfaction  of  withholding  tax or  other  withholding
liabilities, or that the listing,  registration,  or qualification of any shares
otherwise  deliverable upon such exercise upon any securities  exchange or under
any state or federal  law, or that the  consent or  approval  of any  regulatory
body, is necessary or desirable as a condition of, or in connection  with,  such
exercise or the delivery or purchase of shares  purchased  thereto,  then in any
such event,  such  exercise  shall not be  effective  unless  such  withholding,
listing,  registration,  qualification,  consent,  or  approval  shall have been
effected or obtained free of any conditions not acceptable to the Company.

              Unless  the  shares  of  stock  covered  by  the  Plan  have  been
registered with the Securities and Exchange  Commission pursuant to Section 5 of
the  Securities  Act of l933,  each  optionee  shall,  by  accepting  an option,
represent  and agree,  for  himself and his  transferees  by will or the laws of
descent and  distribution,  that all shares of stock purchased upon the exercise
of  the  option  will  be  acquired  for   investment  and  not  for  resale  or
distribution.  Upon such  exercise  of any  portion  of an  option,  the  person
entitled  to exercise  the same  shall,  upon  request of the  Company,  furnish
evidence   satisfactory   to  the  Company   (including  a  written  and  signed
representation)  to the effect  that the shares of stock are being  acquired  in
good faith for investment and not for resale or distribution.  Furthermore,  the
Company  may,  if  it  deems   appropriate,   affix  a  legend  to  certificates
representing  shares of stock purchased upon exercise of options indicating that
such shares have not been registered with the Securities and Exchange Commission
and may so notify the Company's  transfer agent.  Such shares may be disposed of
by an  optionee in the  following  manner  only:  (l)  pursuant to an  effective
registration  statement  covering  such  resale or reoffer,  (2)  pursuant to an
applicable  exemption  from  registration  as indicated in a written  opinion of
counsel  acceptable to the Company,  or (3) in a transaction  that meets all the
requirements of Rule l44 of the Securities and Exchange Commission. If shares of
stock covered by the Plan have been  registered with the Securities and Exchange
Commission,  no such  restrictions on resale shall apply,  except in the case of
optionees who are directors, officers, or principal shareholders of the Company.
Such persons may dispose of shares only by one of the three aforesaid methods.

         9. Use of Proceeds.  The proceeds received by the Company from the sale
of Common Stock pursuant to the exercise of Options granted under the Plan shall
be added to the Company's general funds and used for general corporate purposes.

         l0.  Amendment,  Suspension,  and  Termination  of Plan.  The  Board of
Directors may alter,  suspend, or discontinue the Plan, but may not, without the
approval of a majority of those holders of the Company's  Common Stock voting in
person  or by proxy  at any  meeting  of the  Company's  shareholders,  make any
alteration  or amendment  thereof which  operates to (a) abolish the  Committee,
change the qualification of its members,  or withdraw the  administration of the
Plan from its supervision, (b) make any material change in the class of eligible
employees  as defined in  paragraph  5, (c)  increase the total number of shares
reserved  for  purposes  of this Plan except as  provided  in  paragraph  7, (d)
increase  the  total  number of shares  for  which an option or  options  may be
granted to any one  employee,  (e)  extend  the term of the Plan or the  maximum
option  periods  provided in paragraph 6, (f) decrease the minimum  option price
provided in paragraph  6, except as provided in  paragraph 7, or (g)  materially
increase the benefits accruing to employees participating under this Plan.

         Unless the Plan shall  theretofore  have been  terminated by the Board,
the Plan shall  terminate  ten years after the  effective  date of the Plan.  No
Option may be granted  during any  suspension  or after the  termination  of the
Plan. No amendment,  suspension,  or termination  of the Plan shall,  without an
Optionee's  consent,  alter or impair any of the rights or obligations under any
Option theretofore granted to such Optionee under the Plan.

         11.  Limitations.  Every right of action by or on behalf of the Company
or by any shareholder  against any past,  present or future member of the Board,
or any officer or employee of the Company  arising out of or in connection  with
this Plan shall,  irrespective of the place where such action may be brought and
irrespective of the place of residence of any such director, officer or employee
cease and be barred by the expiration of one year from whichever is the later of
(a) the date of the act or  omission  in  respect  of which such right of action
arises; or (b) the first date upon which there has been made generally available
to  shareholders  an annual report of the Company or any proxy statement for the
annual  meeting of  shareholders  following the issuance of such annual  report,
which annual  report and proxy  statement  alone or together set forth,  for the
related  period,  the number of shares issuable upon the exercise of the options
granted  pursuant to this Plan;  and any and all right of action by any employee
(past,  present or future)  against the Company  arising out of or in connection
with  this Plan  shall,  irrespective  of the place  where  such  action  may be
brought,  cease and be barred by the expiration of one year from the date of the
act or omission in respect of which such right of action arises.

         l2.  Governing  Law.  The Plan shall be  governed  by the laws of the
State of Colorado.

         l3.  Expenses of  Administration.  All costs and expenses incurred in
the operation and administration of this Plan shall be borne by the Company.

                                  CEL-SCI CORPORATION



                                  By -------------------------






<PAGE>


                                 EXHIBIT 4(e)



<PAGE>


                             CEL-SCI CORPORATION
                               STOCK BONUS PLAN


         l.  Purpose.  The purpose of this Plan is to advance the  interests  of
Cel-Sci  Corporation  (the "Company") and its  shareholders,  by encouraging and
enabling selected officers, directors,  consultants and key employees upon whose
judgment,  initiative  and effort  the  Company  is  largely  dependent  for the
successful conduct of its business, to acquire and retain a proprietary interest
in the Company by ownership of its stock,  to keep  personnel of experience  and
ability  in the  employ  of  the  Company  and  to  compensate  them  for  their
contributions  to the growth and profits of the Company and thereby  induce them
to continue to make such contributions in the future.

         2.   Definitions.

              A.   "Board" shall mean the board of directors of the Company.

              B.   "Committee"   means  the   directors   duly   appointed  to
administer the Plan.

              C.   "Plan" shall mean this Stock Bonus Plan.

              D.  "Bonus  Share"  shall mean the  shares of common  stock of the
Company  reserved  pursuant to Section 4 hereof and any such shares  issued to a
Recipient pursuant to this Plan.

              E.   "Recipient"  shall mean any individual  rendering  services
for the Company to whom shares are granted pursuant to this Plan.

         3.  Administration  of  Plan.  The  Plan  shall  be  administered  by a
committee of two or more directors appointed by the Board (the "Committee"). The
Committee shall report all action taken by it to the Board.  The Committee shall
have full and final  authority in its  discretion,  subject to the provisions of
the Plan,  to determine the  individuals  to whom and the time or times at which
Bonus  Shares shall be granted and the number of Bonus  Shares;  to construe and
interpret  the  Plan;  and to make all other  determinations  and take all other
actions deemed necessary or advisable for the proper administration of the Plan.
All such  actions  and  determinations  shall be  conclusively  binding  for all
purposes and upon all persons.

         4. Bonus  Share  Reserve.  There  shall be  established  a Bonus  Share
Reserve to which shall be credited 100,000 shares of the Company's common stock.
In the event that the shares of common stock of the Company should,  as a result
of a stock split or stock dividend or combination of shares or any other change,
or exchange for other securities by  reclassification,  reorganization,  merger,
consolidation,  recapitalization  or  otherwise,  be  increased  or decreased or
changed into or exchanged for, a different  number or kind of shares of stock or
other securities of the Company or of another corporation,  the number of shares

<PAGE>

then  remaining in the Bonus Share  Reserve shall be  appropriately  adjusted to
reflect such action.  Upon the grant of shares hereunder,  this reserve shall be
reduced by the number of shares so granted.  Distributions  of Bonus Shares may,
as the Committee shall in its sole discretion determine, be made from authorized
but unissued shares or from treasury shares.  All authorized and unissued shares
issued  as Bonus  Shares in  accordance  with the Plan  shall be fully  paid and
nonassessable and free from preemptive rights.

         5. Eligibility,  and Granting and Vesting of Bonus Shares. Bonus Shares
may be  granted  under  the  Plan  to the  Company's  employees,  directors  and
officers, and consultants or advisors to the Company, provided however that bona
fide  services  shall be  rendered  by such  consultants  or  advisors  and such
services  must not be in  connection  with the offer or sale of  securities in a
capital-raising transaction.

              The Committee, in its sole discretion, is empowered to grant to an
eligible Participant a number of Bonus Shares as it shall determine from time to
time.  Each grant of these Bonus  Shares  shall  become  vested  according  to a
schedule to be established by the Committee  directors at the time of the grant.
For  purposes  of this plan,  vesting  shall mean the  period  during  which the
recipient must remain an employee or provide  services for the Company.  At such
time as the  employment  of the  Recipient  ceases,  any shares not fully vested
shall be  forfeited  by the  Recipient  and shall be returned to the Bonus Share
Reserve. The Committee, in its sole discretion,  may also impose restrictions on
the future  transferability of the bonus shares, which restrictions shall be set
forth on the notification to the Recipient of the grant.

              The aggregate number of Bonus Shares which may be granted pursuant
to this Plan shall not exceed the amount available  therefore in the Bonus Share
Reserve.

         6. Form of Grants.  Each grant shall specify the number of Bonus Shares
subject thereto, subject to the provisions of Section 5 hereof.

              At the time of making any grant,  the  Committee  shall advise the
Recipient  by  delivery  of  written  notice,  in the form of  Exhibit  A hereto
annexed.

         7.   Recipients' Representations.

              A. The  Committee may require that, in acquiring any Bonus Shares,
the  Recipient  agree with,  and represent to, the Company that the Recipient is
acquiring  such Bonus Shares for the purpose of  investment  and with no present
intention  to  transfer,  sell  or  otherwise  dispose  of  shares  except  such
distribution by a legal  representative as shall be required by will or the laws
of any jurisdiction in winding-up the estate of any Recipient. Such shares shall
be transferable  thereafter  only if the proposed  transfer shall be permissible
pursuant  to  the  Plan  and  if,  in the  opinion  of  counsel  (who  shall  be
satisfactory  to  the  Committee),  such  transfer  shall  at  such  time  be in
compliance with applicable securities laws.

<PAGE>             

          B. To effectuate Paragraph A above, the Recipient shall deliver to
 the Committee,  in duplicate, an agreement in writing, signed by the Recipient
, in form and  substance  as set forth in Exhibit B hereto  annexed,  and the
Committee shall forthwith  acknowledge its receipt thereof. 8. Restrictions
Upon Issuance.

              A.  Bonus  Shares  shall   forthwith   after  the  making  of  any
representations  required  by  Section 6 hereof,  or if no  representations  are
required then within  thirty (30) days of the date of grant,  be duly issued and
transferred and a certificate or certificates for such shares shall be issued in
the  Recipient's  name.  The Recipient  shall  thereupon be a  shareholder  with
respect to all the shares represented by such certificate or certificates, shall
have all the rights of a shareholder with respect to all such shares,  including
the  right  to  vote  such  shares  and  to  receive  all  dividends  and  other
distributions  (subject to the  provisions  of Section  7(B)  hereof)  paid with
respect to such shares. Certificates of stock representing Bonus Shares shall be
imprinted  with a legend to the effect that the shares  represented  thereby are
subject to the  provisions  of this  Agreement,  and to the vesting and transfer
limitations established by the Committee, and each transfer agent for the common
stock shall be instructed to like effect with respect of such shares.

B. In the event  that,  as the  result  of a stock  split or stock  dividend  or
combination of shares or any other change, or exchange for other securities,  by
reclassification,  reorganization,  merger,  consolidation,  recapitalization or
otherwise,  the  Recipient  shall,  as  owner of the  Bonus  Shares  subject  to
restrictions  hereunder, be entitled to new or additional or different shares of
stock or securities, the certificate or certificates for, or other evidences of,
such new or additional or different shares or securities,  together with a stock
power or other  instrument  of transfer  appropriately  endorsed,  shall also be
imprinted  with a legend as provided in Section 7(A),  and all provisions of the
Plan relating to restrictions  herein set forth shall thereupon be applicable to
such  new or  additional  or  different  shares  or  securities  to  the  extent
applicable to the shares with respect to which they were distributed.

              C. The grant of any Bonus Shares shall be subject to the condition
that if at any time the  Company  shall  determine  in its  discretion  that the
satisfaction of withholding tax or other  withholding  liabilities,  or that the
listing,  registration,  or qualification of any Bonus Shares upon such exercise
upon any  securities  exchange  or under any state or federal  law,  or that the
consent or approval of any  regulatory  body,  is  necessary  or  desirable as a
condition of, or in connection  with, the issuance of any Bonus Shares,  then in
any such event,  such exercise shall not be effective  unless such  withholding,
listing,  registration,  qualification,  consent,  or  approval  shall have been
effected or obtained free of any conditions not acceptable to the Company.
              
<PAGE>

D.  Unless  the  Bonus  Shares  covered  by  the  Plan  have  been
registered with the Securities and Exchange  Commission pursuant to Section 5 of
the Securities Act of l933,  each Recipient  shall,  by accepting a Bonus Share,
represent  and agree,  for  himself and his  transferees  by will or the laws of
descent and distribution, that all Bonus Shares were acquired for investment and
not for resale or distribution.  Upon such exercise of any portion of an option,
the person  entitled to exercise the same shall,  upon request of the Committee,
furnish evidence  satisfactory to the Committee  (including a written and signed
representation)  to the effect  that the shares of stock are being  acquired  in
good faith for investment and not for resale or distribution.  Furthermore,  the
Committee  may,  if  it  deems  appropriate,  affix  a  legend  to  certificates
representing  Bonus  Shares  indicating  that such  Bonus  Shares  have not been
registered  with the  Securities  and Exchange  Commission and may so notify the
Company's  transfer agent.  Such shares may be disposed of by a Recipient in the
following  manner  only:  (l) pursuant to an  effective  registration  statement
covering such resale or reoffer,  (2) pursuant to an applicable  exemption  from
registration  as indicated  in a written  opinion of counsel  acceptable  to the
Company,  or (3) in a transaction that meets all the requirements of Rule l44 of
the Securities and Exchange Commission. If Bonus Shares covered by the Plan have
been   registered  with  the  Securities  and  Exchange   Commission,   no  such
restrictions  on resale shall apply,  except in the case of  Recipients  who are
directors,  officers, or principal shareholders of the Company. Such persons may
dispose of shares only by one of the three aforesaid methods.

         9.  Limitations.  Neither the action of the Company in establishing the
Plan,  nor any action taken by it nor by the Committee  under the Plan,  nor any
provision  of the Plan,  shall be construed as giving to any person the right to
be retained in the employ of the Company.

              Every  right of action by or on  behalf of the  Company  or by any
shareholder  against  any past,  present or future  member of the Board,  or any
officer or  employee of the Company  arising out of or in  connection  with this
Plan  shall,  irrespective  of  the  place  where  action  may  be  brought  and
irrespective of the place of residence of any such director, officer or employee
cease and be barred by the expiration of one year from whichever is the later of
(a) the date of the act or  omission  in  respect  of which such right of action
arises; or (b) the first date upon which there has been made generally available
to  shareholders  an annual report of the Company or any proxy statement for the
annual  meeting of  shareholders  following the issuance of such annual  report,
which annual  report and proxy  statement  alone or together set forth,  for the
related  period,  the number of shares issued pursuant to this Plan; and any and
all right of action by any  employee  (past,  present  or  future)  against  the
Company  arising out of or in connection  with this Plan shall,  irrespective of
the place where action may be brought,  cease and be barred by the expiration of
one year from the date of the act or  omission in respect of which such right of
action arises.

<PAGE>        


        l0.  Amendment,  Suspension or  Termination  of the Plan.  The Board of
Directors may alter,  suspend, or discontinue the Plan, but may not, without the
approval of a majority of those holders of the Company's  Common Stock voting in
person  or by proxy  at any  meeting  of the  Company's  shareholders,  make any
alteration  or amendment  thereof which  operates to (a) abolish the  Committee,
change the qualification of its members,  or withdraw the  administration of the
Plan from its supervision, (b) make any material change in the class of eligible
employees  as defined in  paragraph  5, (c)  increase the total number of shares
reserved for purposes of this Plan except as provided in paragraph 4, (d) extend
the term of the Plan or,  (e)  materially  increase  the  benefits  accruing  to
persons participating under this Plan.

         Unless the Plan shall  theretofore  have been  terminated by the Board,
the Plan shall  terminate  ten years after the  effective  date of the Plan.  No
Bonus Share may be granted during any suspension or after the termination of the
Plan. No amendment,  suspension,  or  termination  of the Plan shall,  without a
recipient's consent,  alter or impair any of the rights or obligations under any
Bonus Share theretofore granted to such recipient under the Plan.

         ll.  Governing  Law.  The Plan shall be  governed  by the laws of the
State of Colorado.

         l2.  Expenses of  Administration.  All costs and expenses incurred in
the operation and administration of this Plan shall be borne by the Company.


                                  CEL-SCI CORPORATION



                                  By--------------------------



<PAGE>


                                  - EXHIBIT A -
                              CEL-SCI CORPORATION
                                STOCK BONUS PLAN

         TO:  Recipient:  
          PLEASE BE ADVISED  that  CEL-SCI  Corporation  has on the date  hereof
     granted to the  Recipient the number of Bonus Shares as set forth under and
     pursuant to the Stock Bonus Plan. Before these shares are to be issued, the
     Recipient  must deliver to the Committee that  administers  the Stock Bonus
     Plan an agreement in duplicate,  in the form as Exhibit B hereto. The Bonus
     Shares  are  issued   subject  to  the   following   vesting  and  transfer
     limitations.

         Vesting:
         -------

         Number of Shares                   Date of Vesting
         ---------------                    ---------------


         Transfer Limitations:
         --------------------


                               CEL-SCI CORPORATION


                               By-------------------------

   ------------
     Date


<PAGE>


                                 - EXHIBIT B -


CEL-SCI Corporation
8229 Boone Blvd., Suite 802
Vienna,  Virginia  22182


Gentlemen: 

          I represent and agree that said Bonus Shares are being  acquired by me
     for  investment and that I have no present  intention to transfer,  sell or
     otherwise dispose of such shares,  except as permitted pursuant to the Plan
     and in compliance with applicable  securities  laws, and agree further that
     said shares are being acquired by me in accordance  with and subject to the
     terms,  provisions  and  conditions  of said Plan, to all of which I hereby
     expressly  assent.  These agreements shall bind and inure to the benefit of
     my heirs, legal representatives, successors and assigns.

         My address of record is:


         and my social security number:                              .

                                  Very truly yours,




Receipt of the above is hereby acknowledged.

                             CEL-SCI CORPORATION



                            By--------------------
      ----------
        Date               its----------------------





<PAGE>


                                  EXHIBIT 5



<PAGE>


                                June 23, 1998


CEL-SCI Corporation
8229 Boone Blvd., Suite 802
Vienna,  Virginia 22182 

 Gentlemen:  

               This letter will  constitute  an opinion upon the legality of the
          sale  by  CEL-SCI  Corporation,  a  Colorado  corporation,  of  up  to
          1,600,000   shares  of  Common  Stock,  all  as  referred  to  in  the
          Registration  Statement  on Form  S-8  filed by the  Company  with the
          Securities and Exchange  Commission.  We have examined the Articles of
          Incorporation, the Bylaws and the minutes of the Board of Directors of
          the Company and the  applicable  laws of the State of Colorado,  and a
          copy of the Registration  Statement.  In our opinion,  the Company has
          duly  authorized the issuance of the shares of stock  mentioned  above
          and such shares when issued will be legally  issued,  fully paid,  and
          nonassessable.

                                  Very truly yours,

                                  HART & TRINEN


                                  By  /s/ William T. Hart
                                    ---------------------            
                                      William T. Hart


<PAGE>


                                  EXHIBIT 23

<PAGE>




INDEPENDENT AUDITORS' CONSENT



We consent to the incorporation by reference in this  Registration  Statement of
CEL-SCI Corporation on Form S-8 of our report dated December 8, l997,  appearing
in the  Annual  Report on Form l0-K of  CEL-SCI  Corporation  for the year ended
September 30, l997.







DELOITTE & TOUCHE LLP
Washington, D.C.
June 17, l998


<PAGE>


                             CONSENT OF ATTORNEYS

              Reference  is  made  to  the  Registration  Statement  of  CEL-SCI
Corporation on Form S-8 whereby the Company proposes to sell 1,600,000 shares of
the Company's Common Stock.  Reference is also made to Exhibit 5 included in the
Registration Statement relating to the validity of the securities proposed to be
issued and sold.

         We hereby consent to the use of our opinion  concerning the validity of
the securities proposed to be issued and sold.

                                  Very truly yours,

                                  HART & TRINEN



                                  By  /s/ William T. Hart
                                     ---------------------
                                       William T. Hart

Denver, Colorado
June 23, 1998



<PAGE>




                                  EXHIBIT 99


<PAGE>




                                 - EXHIBIT B -


CEL-SCI Corporation
8229 Boone Blvd., Suite 802
Vienna,  Virginia  22182

Gentlemen: 

               I represent  and agree that said Bonus Shares are being  acquired
          by me for investment and that I have no present intention to transfer,
          sell or otherwise dispose of such shares, except as permitted pursuant
          to the Plan and in compliance  with  applicable  securities  laws, and
          agree further that said shares are being  acquired by me in accordance
          with and subject to the terms, provisions and conditions of said Plan,
          to all of which I hereby expressly assent. These agreements shall bind
          and  inure  to  the  benefit  of  my  heirs,  legal   representatives,
          successors and assigns.

         My address of record is:


         and my social security number:                              .

                                  Very truly yours,




Receipt of the above is hereby acknowledged.

                             CEL-SCI CORPORATION



      -------                By-----------------------
        Date                 its---------------------




<PAGE>


                               CEL-SCI CORPORATION

                                  Common Stock

      THESE SECURITIES INVOLVE A HIGH DEGREE OF RISK. SEE "RISK FACTORS".


         THESE   SECURITIES  HAVE  NOT  BEEN  APPROVED  OR  DISAPPROVED  BY  THE
SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES  COMMISSION,  NOR HAS
THE COMMISSION OR ANY STATE  SECURITIES  COMMISSION  PASSED UPON THE ACCURACY OR
ADEQUACY OF THIS PROSPECTUS.  ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL
 OFFENSE.

         This  Prospectus  relates to shares (the "Shares") of common stock (the
"Common  Stock")  of CEL-SCI  Corporation  (the  "Company")  which may be issued
pursuant  to  certain  employee  incentive  plans  adopted by the  Company.  The
employee  incentive  plans provide for the grant,  to selected  employees of the
Company and other persons, of either stock bonuses or options to purchase shares
of the Company's Common Stock. Persons who received Shares pursuant to the Plans
and who are offering such Shares to the public by means of this  Prospectus  are
referred to as the "Selling Shareholders".

         The Company has  Incentive  Stock  Option  Plans,  Non-Qualified  Stock
Option Plans and Stock Bonus Plans.  In some cases the plans described above are
collectively  referred to as the "Plans".  The terms and conditions of any stock
bonus and the terms and  conditions  of any options,  including the price of the
shares of Common Stock issuable on the exercise of options,  are governed by the
provisions  of the  respective  Plans  and  the  stock  bonus  or  stock  option
agreements between the Company and the Plan participants.

         The  Selling  Shareholders  may offer the  shares  from time to time in
negotiated  transactions in the  over-the-counter  market, at fixed prices which
may be changed from time to time,  at market  prices  prevailing  at the time of
sale,  at prices  related  to such  prevailing  market  prices or at  negotiated
prices.  The Selling  Shareholders  may effect such  transactions by selling the
Shares to or through  securities  broker/dealers,  and such  broker/dealers  may
receive compensation in the form of discounts,  concessions, or commissions from
the  Selling  Shareholders  and/or  the  purchasers  of the Shares for whom such
broker/dealers  may act as  agent or to whom  they  sell as  principal,  or both
(which  compensation  as to a  particular  broker/dealer  might be in  excess of
customary commissions). See "Selling Shareholders" and "Plan of Distribution".

         None of the  proceeds  from  the  sale  of the  Shares  by the  Selling
Shareholders will be received by the Company. The Company has agreed to bear all
expenses (other than underwriting  discounts,  selling  commissions and fees and
expenses of counsel and other advisers to the Selling Shareholders). The Company
has agreed to indemnify the Selling  Shareholders  against certain  liabilities,
including  liabilities  under  the  Securities  Act of  1933,  as  amended  (the
"Securities Act").

                         The date of this Prospectus is --- , 1998.


<PAGE>




                                         
                            AVAILABLE INFORMATION

         The  Company  is  subject  to  the  information   requirements  of  the
Securities  Exchange  Act  of  1934  (the  "Exchange  Act")  and  in  accordance
therewith,  files reports and other information with the Securities and Exchange
Commission (the "Commission").  Proxy statements,  reports and other information
concerning  the  Company  can be  inspected  and  copied  at  Room  1024  of the
Commission's office at 450 Fifth Street, N.W.,  Washington,  D.C. 20549, and the
Commission's Regional Offices in New York (7 World Trade Center, Suite l300, New
York, New York 10048), and Chicago (Northwestern Atrium Center, 500 West Madison
Street, Suite 1400, Chicago,  Illinois 60661-2511),  and copies of such material
can be obtained from the Public Reference Section of the Commission at 450 Fifth
Street, N.W.,  Washington,  D.C. 20549, at prescribed rates. Certain information
concerning the Company is also available at the Internet Web Site  maintained by
the Securities and Exchange Commission at www.sec.gov.  This Prospectus does not
contain all  information set forth in the  Registration  Statement of which this
Prospectus  forms a part and exhibits  thereto  which the Company has filed with
the Commission under the Securities Act and to which reference is hereby made.

                     DOCUMENTS INCORPORATED BY REFERENCE

         The Company will provide, without charge, to each person to whom a copy
of this  Prospectus  is  delivered,  including any  beneficial  owner,  upon the
written or oral  request of such person,  a copy of any or all of the  documents
incorporated by reference herein (other than exhibits to such documents,  unless
such exhibits are specifically  incorporated by reference into this Prospectus).
Requests should be directed to:

                             CEL-SCI Corporation
                               8229 Boone Blvd.
                                  Suite 802
                            Vienna, Virginia 223l4
                                (703) 506-9460
                             Attention: Secretary

         The  following  documents  filed  with the  Commission  by the  Company
(Commission  File No.  0-11503) are hereby  incorporated  by reference into this
Prospectus:

         (1) The Company's  Annual Report on Form 10-K for the fiscal year ended
September 30, 1997; and

         (2) The Company's  report on Form 10-Q for the quarter  ended  December
31, 1997.

         (3) The  Company's  report on Form 10-Q for the quarter ended March 31,
1998.

         (4) Proxy  Statement  relating to the May 29,  1998  Annual  Meeting of
Shareholders.

<PAGE>      

  All  documents  filed with the  Commission  by the Company  pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the date of
this Prospectus and prior to the termination of the offering  registered  hereby
shall be deemed to be incorporated by reference into this Prospectus and to be a
part  hereof  from the  date of the  filing  of such  documents.  Any  statement
contained in a document  incorporated  or deemed to be incorporated by reference
herein  shall be deemed to be modified or  superseded  for the  purposes of this
Prospectus  to  the  extent  that  a  statement   contained  herein  or  in  any
subsequently  filed  document which also is or is deemed to be  incorporated  by
reference  herein  modifies or  supersedes  such  statement.  Such  statement so
modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this Prospectus.



<PAGE>


                              TABLE OF CONTENTS
                                                                        PAGE




THE COMPANY ......................................................        5

RISK FACTORS .....................................................        7

DILUTION  AND  COMPARATIVE  SHARE  DATA  .........................       10

USE OF PROCEEDS...................................................       14

SELLING SHAREHOLDERS..............................................       14

PLAN OF  DISTRIBUTION.............................................       17

DESCRIPTION  OF COMMON STOCK......................................       18

GENERAL ..........................................................       18




<PAGE>


                                 THE COMPANY

         CEL-SCI   Corporation   (the   "Company")  was  formed  as  a  Colorado
corporation in 1983. The Company is involved in the research and  development of
certain  drugs  and  vaccines.   The  Company's   first  product,   MULTIKINETM,
manufactured  using the Company's  proprietary cell culture  technologies,  is a
combination,  or "cocktail", of natural human interleukin-2 ("IL-2") and certain
lymphokines  and  cytokines.  MULTIKINE  is being  tested to  determine if it is
effective in improving  the immune  response of cancer  patients.  The Company's
second  product,  HGP-30,  is being  tested to  determine  if it is an effective
treatment/vaccine  against the AIDS virus.  In 1996, the Company  acquired a new
patented T-cell Modulation Process which uses  "heteroconjugates"  to direct the
body to choose a specific immune  response.  The Company intends to use this new
technology to improve the cellular  immune  response of persons  vaccinated with
HGP-30 and to develop  potential  treatments  and/or  vaccines  against  various
diseases.   Present  target  diseases  are  AIDS,   herpes   simplex,   malaria,
tuberculosis, prostate cancer and breast cancer.

         Before  human  testing can begin with  respect to a drug or  biological
product, preclinical studies are conducted in laboratory animals to evaluate the
potential efficacy and the safety of a product. Human clinical studies generally
involve  a  three-phase  process.  The  initial  clinical  evaluation,  Phase I,
consists of administering  the product and testing for safe and tolerable dosage
levels.  Phase II trials continue the evaluation of immunogenicity and determine
the appropriate dosage for the product, identify possible side effects and risks
in a larger group of subjects, and provide preliminary  indications of efficacy.
Phase III trials  consist of testing  for actual  clinical  efficacy  for safety
within an expanded group of patients at geographically dispersed test sites.

         In March  1995,  the  Canadian  Health  Protection  Branch,  Health and
Welfare  Ministry  gave  clearance  to the  Company to start a phase I/II cancer
study using MULTIKINE.  The study, which will enroll twenty head and neck cancer
patients who have failed conventional  treatments,  will be conducted at several
sites in the United States and Canada and is designed to evaluate safety,  tumor
responses  and immune  responses in patients  treated with  multiple  courses of
MULTIKINE.   The  length  of  time  that  each   patient   will  remain  on  the
investigational treatment will depend on the patient's response to treatment.

         In February  1996 the FDA  authorized  the start of two human  clinical
studies using  MULTIKINE and focusing on prostate and head and neck cancer.  The
prostate study was conducted at Jefferson Hospital in Philadelphia, Pennsylvania
and involved prostate cancer patients who had failed on hormonal  therapy.  Five
patients  completed the treatment and the data from this study  demonstrated the
safety and feasibility of using  MULTIKINE in the treatment of prostate  cancer.
Biopsies  from the  patients  in the  study  also  suggest  the  recruitment  of
inflammatory cells to the tumor site. Based on these findings, investigators are
currently  preparing  a new  protocol  for  evaluation  by the FDA to study  the
ability of  MULTIKINE  to treat  patients  with  prostate  cancer.  The study is
expected to test MULTIKINE as a therapy to be used prior to surgical  removal of
the  prostate  gland.  The head and neck  cancer  study  will  involve up twenty
patients who have failed using conventional therapies.  The head and neck cancer
study in the U.S. is being conducted in conjunction with the Company's  Canadian
head and neck cancer study.

<PAGE>        


         In January l997 the FDA authorized a clinical trial using  MULTIKINE to
determine its safety in the potential treatment of HIV infected  individuals and
to determine its effect on various immune system responses.

         In  April  1997,   pursuant  to   authorization   from  Israeli  health
authorities,  a clinical trial was begun using  MULTIKINE to treat head and neck
cancer patients.  In September l997 the Company started a similar clinical trial
in Canada.  The Canadian  study will involve up to 21 patients who are scheduled
for surgery or radiation.

         Viral  Technologies,  Inc.  ("VTI"),  a wholly-owned  subsidiary of the
Company, is engaged in the development of a possible treatment/vaccine for AIDS.
VTI's  technology  may also have  application in the treatment of AIDS- infected
individuals and the diagnosis of AIDS. VTI's AIDS treatment/vaccine, HGP-30, has
completed  certain Phase I human  clinical  trials.  In the Phase I trials,  the
vaccine was  administered to volunteers who were not infected with the HIV virus
in an effort to determine safe and tolerable dosage levels.

         In April 1995 VTI,  with the approval of the  California  Department of
Health  Services Food and Drug Branch (FDB),  began  another  clinical  trial in
California  using  volunteers  who received  two  vaccinations.  The  volunteers
receiving  the two lowest  dosage  levels were asked to donate  blood for a SCID
mouse HIV challenge study. The SCID mouse is considered by many scientists to be
the best  available  animal model for HIV because it lacks its own immune system
and  therefore  permits  human cell growth.  White blood cells from the five (5)
vaccinated  volunteers  and from normal donors were injected into groups of SCID
mice. They were then  challenged  with high levels of a different  strain of the
HIV virus  than the one from which  HGP-30 is  derived.  Infection  by virus was
determined and confirmed by two different  assays,  p24 antigen,  a component of
the virus core, and reverse  transcriptase  activity,  an enzyme critical to HIV
replication.  Approximately  78% of the SCID mice given  blood  from  vaccinated
volunteers  showed no HIV infection  after virus challenge as compared to 13% of
the mice given blood from unvaccinated donors.

         In  September  1997 VTI  completed a Phase I safety study of the HGP-30
AIDS vaccine in 24 HIV infected  patients.  The study showed that  immunizations
with the HGP-30 vaccine coupled with KLH were safe in AIDS patients.

    In June 1998  approval was received to begin  clinical  trials of the HGP-30
vaccine in the  Netherlands.  The upcoming study using VTI's vaccine will be the
only  Phase II AIDS  vaccine  study  ongoing  in  Europe  and will  focus on the
vaccine's  ability to generate immune responses  against the viral subtypes most
common  around  the globe.  In the  upcoming  trial,  30  healthy,  HIV-negative
volunteers  will be studied at the Institute for Clinical  Pharmacology,  Pharna
Bio Research, in the Netherlands and will receive one of three different dosages
of the  vaccine.  The results  from this Phase II trial are  expected to produce
critical dose response information which will be useful for future trials.

        
<PAGE>

         The Company's  main focus is now to determine the ability of the HGP-30
vaccine to prevent, as opposed to only treat, AIDS.

         All of the Company's  products are in the early stages of  development.
The Company does not expect to develop commercial products for several years, if
at all.  The  Company  has had  operating  losses  since its  inception,  had an
accumulated  deficit of  approximately  $38,695,000  at September 30, 1997,  and
expects to incur substantial losses for the foreseeable future.

         The Company's  executive offices are located at 8229 Boone Blvd., Suite
802, Vienna, Virginia 22314, and its telephone number is (703) 549-5293.

         As of May 15, 1998 the Company had  11,515,736  shares of Common  Stock
issued and outstanding.

                                 RISK FACTORS

         The securities  offered hereby  represent a speculative  investment and
involve a high degree of risk. Therefore, prospective investors should read this
Prospectus and carefully  consider,  among others, the following risk factors in
addition to the other  information set forth in this Prospectus  prior to making
an investment.

         Offering  Proceeds.  This  Offering is being made by certain  Selling
Shareholders.  The Company will not receive any proceeds  from the sale of the
shares by the Selling Shareholders.

         Lack of Revenues and History of Loss.  The Company has had only limited
revenues  since it was  formed  in 1983.  Since  the date of its  formation  and
through  March 31, 1998,  the Company has  incurred net losses of  approximately
$(41,526,000).  The Company has relied  principally  upon the proceeds of public
and private sales of securities  to finance its  activities to date.  All of the
Company's  potential  products are in the early stages of  development,  and any
commercial  sale of these  products  will be many years away.  Accordingly,  the
Company expects to incur substantial losses for the foreseeable future.

         Need for Additional  Capital.  Clinical and other studies  necessary to
obtain  approval of a new drug can be time  consuming and costly,  especially in
the United States, but also in foreign countries.  The different steps necessary
to  obtain   regulatory   approval,   especially  that  of  the  Food  and  Drug
Administration  ("FDA"),  involve significant costs. The Company expects that it
will need  additional  financing  in order to fund the costs of future  clinical
trials, related research,  and general and administrative  expenses. The Company
may be forced to delay or postpone development and research  expenditures if the
Company  is  unable  to  secure  adequate  sources  of  funds.  These  delays in
development  may have an adverse  effect on the  Company's  ability to produce a
timely and competitive product.  There can be no assurance that the Company will
be able to obtain additional funding from other sources.

        
<PAGE>

          Viral  Technologies,  Inc. ("VTI"), a wholly-owned  subsidiary of the
Company,  is dependent  upon funding from the Company for its  operations  and
research programs.

         Cost Estimates.  The Company's  estimates of the costs  associated with
future clinical trials and research may be  substantially  lower than the actual
costs of these  activities.  If the Company's cost estimates are incorrect,  the
Company will need additional funding for its research efforts.

         Government  Regulation - FDA Approval.  Products which may be developed
by the  Company  or Viral  Technologies,  Inc.  (or  which may be  developed  by
affiliates or licensees)  will require  regulatory  approvals  prior to sale. In
particular,  therapeutic agents and diagnostic products are subject to approval,
prior to general  marketing,  by the FDA in the United  States and by comparable
agencies  in  most  foreign   countries.   The  process  of  obtaining  FDA  and
corresponding  foreign approvals is costly and time consuming,  particularly for
pharmaceutical products such as those which might ultimately be developed by the
Company,  Viral  Technologies,  Inc.  or  its  licensees,  and  there  can be no
assurance  that such  approvals  will be  granted.  Any failure to obtain or any
delay in obtaining such approvals may adversely  affect the ability of potential
licensees or the Company to successfully  market any products  developed.  Also,
the extent of adverse  government  regulations  which  might  arise from  future
legislative  or  administrative  action cannot be predicted.  The clinical trial
which the  Company's  affiliate,  Viral  Technologies,  Inc.,  is  conducting in
California  is regulated by  government  agencies in  California  and  obtaining
approvals  from  states  for  clinical  trials is  likewise  expensive  and time
consuming.

         Dependence  on  Others  to  Manufacture  Product.  The  Company  has an
agreement  with an unrelated  corporation  for the  production,  until 2000,  of
MULTIKINE for research and testing purposes.  At present,  this is the Company's
only source of MULTIKINE.  If this corporation could not, for any reason, supply
the  Company  with  MULTIKINE,   the  Company   estimates  that  it  would  take
approximately  six to ten  months  to  obtain  supplies  of  MULTIKINE  under an
alternative  manufacturing  arrangement.  The Company does not know what cost it
would incur to obtain this alternative source of supply.

         Technological  Change.  The  biomedical  field in which the  Company is
involved  is  undergoing  rapid  and  significant   technological   change.  The
successful  development of therapeutic  agents and diagnostic  products  through
Company financed research or as a result of possible licensing arrangements with
pharmaceutical  or other  companies,  will  depend on its  ability  to be in the
technological  forefront  of this  field.  There  can be no  assurance  that the
Company  will  achieve or  maintain  such a  competitive  position or that other
technological developments will not cause the Company's proprietary technologies
to become uneconomical or obsolete.

         Patents.  Certain aspects of the Company's  technologies are covered by
U.S.  and  foreign  patents.  In  addition,  the  Company has a number of patent
applications pending.  There is no assurance that the applications still pending
or which may be filed in the future will result in the  issuance of any patents.
Furthermore,  there is no assurance  as to the breadth and degree of  protection
any issued  patents  might  afford the owners of the  patents  and the  Company.

<PAGE>

Disputes  may arise  between the owners of the patents or the Company and others
as to the scope,  validity and ownership  rights of these or other patents.  Any
defense of the patents could prove costly and time consuming and there can be no
assurance  that the Company or the owners of the patents  will be in a position,
or will deem it advisable,  to carry on such a defense. Other private and public
concerns,  including universities,  may have filed applications for, or may have
been  issued,  patents and are expected to obtain  additional  patents and other
proprietary rights to technology potentially useful or necessary to the Company.
The scope and validity of such patents,  if any, the extent to which the Company
or the  owners of the  patents  may wish or need to  acquire  the rights to such
patents,  and the cost and  availability  of such rights are presently  unknown.
Also, as far as the Company relies upon unpatented proprietary technology, there
is no assurance that others may not acquire or independently develop the same or
similar technology. The Company's first MULTIKINE patent will expire in the year
2000.  Since the Company does not know if it will ever be able to sell MULTIKINE
on a commercial  basis, the Company cannot predict what effect the expiration of
this patent will have on the  Company.  Notwithstanding  the above,  the Company
believes that later issued patents will protect the technology  associated  with
MULTIKINE past the year 2000.

         Product  Liability  and Lack of  Insurance.  Although  the  Company has
product  liability  insurance  for  MULTIKINE  and  its  HGP-30  vaccines,   the
successful  prosecution  of a product  liability  case against the Company could
have a materially adverse effect upon its business if the amount of any judgment
exceeds the Company's insurance coverage.

         Dependence  on  Management  and  Scientific  Personnel.  The Company is
dependent  for  its  success  on the  continued  availability  of its  executive
officers.  The loss of the services of any of the Company's  executive  officers
could have an adverse  effect on the  Company's  business.  The Company does not
carry  key man life  insurance  on any of its  officers.  The  Company's  future
success  will also  depend  upon its  ability  to attract  and retain  qualified
scientific personnel. There can be no assurance that the Company will be able to
hire and retain such necessary personnel.

         Options,  Warrants and Convertible  Securities.  The Company has issued
options,  warrants and other convertible  securities  ("Derivative  Securities")
which allow the holders to acquire  additional  shares of the  Company's  Common
Stock.  In some cases the Company has agreed that, at its expense,  it will make
appropriate  filings with the  Securities  and Exchange  Commission  so that the
securities underlying certain Derivative Securities will be available for public
sale. Such filings could result in substantial  expense to the Company and could
hinder future financings by the Company.

         For the terms of these Derivative Securities,  the holders thereof will
have an  opportunity  to profit  from any  increase  in the market  price of the
Company's Common Stock without assuming the risks of ownership.  Holders of such
Derivative  Securities  may  exercise  and/or  convert  them at a time  when the
Company  could  obtain  additional  capital on terms more  favorable  than those
provided  by the  Derivative  Securities.  The  exercise  or  conversion  of the
Derivative Securities will dilute the voting interest of the owners of presently
outstanding  shares of the Company's  Common Stock and may adversely  affect the

<PAGE>

ability of the Company to obtain additional  capital in the future.  The sale of
the shares of Common  Stock  issuable  upon the  exercise or  conversion  of the
Derivative  Securities  could adversely affect the market price of the Company's
stock. See "Dilution and Comparative Share Data".

         Competition.   The   competition  in  the  research,   development  and
commercialization  of products  which may be used in the prevention or treatment
of cancer and AIDS is intense.  Major pharmaceutical and chemical companies,  as
well as specialized genetic engineering firms, are developing products for these
diseases.  Many of these  companies  have  substantial  financial,  research and
development,  and marketing  resources and are capable of providing  significant
long-term  competition  either by  establishing  in-house  research groups or by
forming collaborative  ventures with other entities.  In addition,  both smaller
companies and non-profit  institutions are active in research relating to cancer
and AIDS and are expected to become more active in the future.

         Lack of Dividends. There can be no assurance that the operations of the
Company will result in any revenues or will be profitable.  At the present time,
the Company intends to use available funds to finance any possible growth of the
Company's  business.  Accordingly,  while  payment of dividends on the Company's
Common Stock rests within the  discretion of the Board of  Directors,  no common
stock dividends have been declared or paid by the Company.  The Company does not
presently  intend  to pay  dividends  on its  common  stock  and there can be no
assurance that dividends will ever be paid.

         Dilution.   Persons   purchasing  the  securities   offered  by  this
Prospectus  will suffer an  immediate  dilution in the per share net  tangible
book value of their Common Stock.

         Preferred Stock. The Company's Articles of Incorporation  authorize the
Company's  Board of Directors to issue up to 200,000 shares of Preferred  Stock.
The  provisions  in the  Company's  Articles  of  Incorporation  relating to the
Preferred  Stock would allow the Company's  directors to issue  Preferred  Stock
with  multiple  votes per share and  dividends  rights which would have priority
over any dividends paid with respect to the Company's Common Stock. The issuance
of Preferred Stock with such rights may make the removal of management difficult
even if such removal would be considered  beneficial to shareholders  generally,
and will have the  effect  of  limiting  shareholder  participation  in  certain
transactions  such as  mergers  or tender  offers if such  transactions  are not
favored by incumbent management.

                     DILUTION AND COMPARATIVE SHARE DATA

         As of May 15,  1998,  the Company had  11,515,736  shares of its Common
Stock  outstanding  with a net  tangible  book value  (total  assets  less total
liabilities and intangible assets) of approximately $1.40 per share.

         The net tangible book value of a share of the Company's Common Stock is
substantially  less  than the  price  which  investors  will pay for the  shares
offered by this Prospectus. The difference between the price paid by persons who
purchase the  Securities  offered by this  Prospectus  and the net tangible book
value of the Company's  Common Stock is the dilution  attributable to each share
of Common Stock.

     
<PAGE>

        "Net  tangible  book value per share" is the amount that  results  from
subtracting the total  liabilities and intangible assets of the Company from its
total  assets  and  dividing  such  amount by the  shares of Common  Stock  then
outstanding.

         The following table reflects the additional  shares which may be issued
as a  result  of  the  exercise  of  outstanding  options  and  warrants  or the
conversion  of other  securities  issued by the Company.  By means of a separate
registration  statement  filed with the Securities  and Exchange  Commission the
shares of common  stock  referenced  in notes A through F are being  offered for
public sale.  The shares of common stock  issuable  upon the exercise of options
which are held by the Company's officers and directors, and which are referenced
in Note G, are being offered for sale by means of this prospectus.  See "Selling
Shareholders".

                                                      Number of       Note
                                                        Shares      Reference

Outstanding as of May 15, 1998                       11,515,736

Shares to be issued upon conversion of
Series D Preferred Stock, assuming
conversion price of $8.28 per share                   1,207,730         A

Shares issuable upon exercise of
Series A and Series B Warrants                        1,100,000         A

Shares issuable upon exercise of
Sales Agent Warrants                                     50,000         B

Shares granted to public relations
consultant and shares issuable
upon exercise of options
granted to financial consultants                        204,000         C

Shares issuable upon exercise of
Class A and Class B Warrants                            233,188         D

Shares issuable upon exercise of warrants
held by former holders of the
Company's Series B Preferred Stock.                      82,250         E

Shares issuable upon exercise of
warrants sold in Company's 1992
Public Offering/1998 Exchange Offer                   1,035,000         F


<PAGE>

Shares  issuable  upon  exercise of options 
and  warrants  granted to  Company's
officers, directors, employees, consultants,
and third parties                                     2,492,346         G

A.       In  December  1997,  the Company  sold 10,000  shares of its Series D
         Preferred  Stock,  550,000  Series A Warrants  and  550,000  Series B
         Warrants,  to  ten  institutional  investors  for  $10,000,000.   The
         Series  D  Preferred  Shares  may be  converted  into  shares  of the
         Company's  Common  Stock.  Prior  to  September  19,  1998  (or  such
         earlier  date as the market  price of the  Company's  Common Stock is
         $3.45  or less for five  consecutive  trading  days)  the  number  of
         shares  issuable upon the conversion of each Series D Preferred Share
         is  to be  determined  by  dividing  $1,000  by  $8.28.  On or  after
         September 19, 1998 the number of shares  issuable upon the conversion
         of each  Series D  Preferred  Share is to be  determined  by dividing
         $1,000 by the lower of (i) $8.28,  or (ii) the  average  price of the
         Company's  common  stock  for any two  trading  days  during  the ten
         trading days  preceding the  conversion  date.  Each Series A Warrant
         allows  the  holder to  purchase  one share of the  Company's  common
         stock for $8.62 at any time prior to December 22,  2001.  Each Series
         B Warrant  allows the holder to purchase  one share of the  Company's
         Common Stock for $9.31 at any time prior to December 22, 2001.

B.       In  connection  with  the  Company's  December  l997  sale of  Series D
         Preferred Shares and Warrants Shoreline Pacific Institutional  Finance,
         the Sales Agent for such offering,  received a commission plus warrants
         to purchase  50,000  shares of the  Company's  Common Stock (the "Sales
         Agent  Warrants").  The Sales Agent Warrants are exercisable at a price
         of $8.62 per share at any time prior to December 22, 2001.

C.       The  Company  has  agreed to issue  9,000  shares of common  stock to a
         public  relations  consultant  and  options  for  the  purchase  of  an
         additional   195,000  shares  of  common  stock  to  certain  financial
         consultants in consideration for services provided to the Company.  The
         options are  exercisable at prices ranging  between $5.00 and $7.31 per
         share and expire between October 1998 and September 2002.

D.       In  December  1996 the  Company  raised  $2,850,000  from the sale of
         units  consisting of 2,850 shares of the Company's Series C Preferred
         Stock,  379,763  Class A Warrants and 379,763  Class B Warrants.  The
         Series  C  Preferred  Shares  were  convertible  into  shares  of the
         Company's  Common Stock on the basis of one share of Preferred  Stock
         for shares of Common  Stock equal in number to the amount  determined
         by  dividing  $1,000  by the 85% of  Closing  Price of the  Company's
         Common Stock (the "Conversion  Price").  The term "Closing Price" was
         

<PAGE>

         defined as the  average  closing  bid price of the  Company's  Common
         Stock over the  five-day  trading  period  ending on the day prior to
         the  conversion of the Preferred  Stock.  Notwithstanding  the above,
         the  Conversion  Price  could not be more than  $4.00.  Each  Class A
         Warrant  entitles the holder to purchase  one share of the  Company's
         common  stock  at a price  of $4.50  per  share at any time  prior to
         March  15,  1998.  Each  Class  B  Warrant  entitles  the  holder  to
         purchase one share of the Company's  common stock at a price of $4.50
         per share at any time prior to March 15,  1999.  As of April 30, 1998
         all shares of the Series C Preferred  Stock had been  converted  into
         9l5,27l  shares  of the  Company's  Common  Stock,  273,163  Series A
         Warrants had been  exercised  and 253,175  Series B Warrants had been
         exercised.

E.       In August  1996 the Company  sold,  in a private  transaction,  5,000
         shares of its Series B Preferred Stock (the  "Preferred  Shares") for
         $5,000,000  or $1,000 per share.  At the  purchasers'  option,  up to
         2,500  Preferred  Shares were  convertible,  on or after  November 7,
         1996 (the  "Effective  Date"),  into shares of the  Company's  Common
         Stock on the basis of one  share of  Preferred  Stock  for  shares of
         Common  Stock  equal in number to the amount  determined  by dividing
         $1,000 by 85% of the Closing  Price of the  Company's  Common  Stock.
         All Preferred Shares were  convertible,  on or after 40 days from the
         Effective  Date,  on the  basis of one share of  Preferred  Stock for
         shares of the  Company's  Common  Stock equal in number of the amount
         determined  by  dividing  $1,000 by 85% of the  Closing  Price of the
         Company's  Common Stock.  The term "Closing Price" was defined as the
         average  closing  bid price of the  Company's  Common  Stock over the
         five-day  trading period ending on the day prior to the conversion of
         the  Preferred  Stock.  Notwithstanding  the  above,  the  conversion
         price  could  not be less  than  $3.60  nor  more  than  $14.75.  The
         Preferred Shares were entitled to a quarterly  dividend of $17.50 per
         share.  Prior to December  20, 1996 1,900  Series B Preferred  Shares
         were  converted  into 527,774  shares of the Company's  common stock.
         In December  1996 the Company  repurchased  2,850  Series B Preferred
         Shares  for  $2,850,000  plus  warrants  which  allow the  holders to
         purchase up to 99,750 shares of the Company's  common stock for $4.25
         per  share at any time  prior  to  December  15,  1999.  The  Company
         raised the funds  required for this  repurchase  from the sale of its
         Series C Preferred  Stock.  In May 1997 all  remaining  250 shares of
         the Series B Preferred  Stock were  converted  into 69,444  shares of
         common  stock.  As of April 30,  l998  Warrants  for the  purchase of
         17,500 shares of common stock had been exercised.

F.       In connection with the Company's  February 1992 public offering,  the
         Company issued  5,175,000  warrants.  Every five warrants  allows the
         warrant  holder to purchase one share of the  Company's  common stock
         for  $6.00 per share at any time  prior to  August 1,  1998.  Between
         January 9, 1998 and  February  17, 1998 the holders of the  Company's
         outstanding  warrants  were given the  opportunity  to  purchase  one
         share of the  Company's  Common  Stock and one  Series A  Warrant  in
         exchange for five  warrants and $6.00 (the  "Exchange  Offer").  Each
         Series A Warrant allows the holder to purchase one  additional  share
         of the  Company's  Common  Stock  for  $l0.00  at any  time  prior to
         February 7, 2000.  During the period of the Exchange  Offer,  582,025
         warrants   were   tendered,   the   Company   received   proceeds  of
         approximately  $698,000 and a total of 116,405 Series A Warrants were
         issued to the warrant holders participating in the Exchange Offer.


<PAGE>


G.       The options are  exercisable at prices ranging from $2.38 to $14.10 per
         share. The Company may also grant options to purchase additional shares
         under its Incentive Stock Option and Non-Qualified Stock Option Plans.


                               USE OF PROCEEDS

         All of the  shares  offered  by this  Prospectus  are being  offered by
certain owners of the Company's Common Stock (the Selling Shareholders) and were
issued by the Company in connection  with the Company's  employee stock bonus or
stock option plans.  None of the proceeds from this offering will be received by
the Company.  Expenses expected to be incurred by the Company in connection with
this  offering  are  estimated  to  be   approximately   $10,000.   The  Selling
Shareholders  have agreed to pay all commissions  and other  compensation to any
securities broker/dealers through whom they sell any of the Shares.

                             SELLING SHAREHOLDERS

         The  Company  has  issued (or may in the  future  issue)  shares of its
common stock to various  persons  pursuant to certain  employee  incentive plans
adopted by the Company.  The employee  incentive plans provide for the grant, to
selected employees of the Company and other persons,  of either stock bonuses or
options to purchase shares of the Company's  Common Stock.  Persons who received
Shares  pursuant to the Plans and who are offering  such Shares to the public by
means of this Prospectus are referred to as the "Selling Shareholders".

         The  Company has  adopted a number of Stock  Option  Plans as well as a
Stock Bonus Plan. A summary  description of these Plans  follows.  In some cases
these Plans are collectively referred to as the "Plans".

         Incentive  Stock Option Plans.  The Company has Incentive  Stock Option
Plans which collectively authorize the issuance of up to 1,100,000 shares of the
Company's  Common Stock to persons that exercise options granted pursuant to the
Plan. Only Company  employees may be granted  options  pursuant to the Incentive
Stock Option Plan.

         Non-Qualified  Stock Option Plans. The Company has Non-Qualified  Stock
Option Plans which collectively authorize the issuance of up to 2,760,000 shares
of the Company's  Common Stock to persons that exercise options granted pursuant
to the Plans.  The Company's  employees,  directors,  officers,  consultants and
advisors  are  eligible to be granted  options  pursuant to the Plans,  provided
however that bona fide services must be rendered by such consultants or advisors
and such services must not be in connection with the offer or sale of securities
in a capital-raising transaction. The option exercise price is determined by the
Committee but cannot be less than the market price of the Company's Common Stock
on the date the option is granted.

        
<PAGE>

         Stock Bonus Plans. The Company has Stock Bonus Plans which collectively
allow for the issuance of up to 140,000 shares of Common Stock.  Such shares may
consist,  in whole or in part, of authorized  but unissued  shares,  or treasury
shares.  Under  the  Stock  Bonus  Plan,  the  Company's  employees,  directors,
officers,  consultants  and  advisors  are  eligible  to  receive a grant of the
Company's  shares,  provided however that bona fide services must be rendered by
consultants  or advisors and such services  must not be in  connection  with the
offer or sale of securities in a capital-raising transaction.

         Summary. The following sets forth certain information,  as of April 30,
1998,  concerning  the stock options and stock  bonuses  granted by the Company.
Each option  represents the right to purchase one share of the Company's  Common
Stock.

                 Total Shares   Shares Reserved  Shares issued   Remaining
                  Reserved      for Outstanding    as Stock      Options/Shares
Name of Plan      Under Plan        Options          Bonus       Under Plans
- -------------     -----------   ----------------  -----------   ---------------
Incentive Stock
 Option Plans      1,100,000        585,216            N/A          496,617
Non-Qualified
Stock Option Plans 2,760,000      1,528,267            N/A          894,524
Stock Bonus Plans    140,000         N/A             5,754          134,246

TOTAL:

         The following  table  summarizes  the options  granted to the Company's
officers, directors, employees and consultants pursuant to the Plans as of April
30, 1998.  Certain options were granted in accordance with the Company's  Salary
Reduction  Plan.  Pursuant to the Salary  Reduction  Plan,  any  employee of the
Company was allowed to receive  options  (exercisable at market price at time of
grant) in exchange for a reduction in such employee's salary.

            Name of
          Option Holder                      Shares Subject to Options (1)
          -------------                      -----------------------------

          Maximilian de Clara                            426,333
          Geert R. Kersten                               811,750
          Patricia B. Prichep                            118,000
          M. Douglas Winship                              67,000
          Eyal Talor, Ph.D                                73,500
          Prem Sarin, Ph.D                                68,500
          Daniel Zimmerman, Ph.D                          61,000
          Mark Soresi                                    105,000
          F. Donald Hudson                               137,000
          Employees and Consultants                      245,400
                                                         -------
            to Company                                 2,113,483


<PAGE>


(1) The options issued to the Company's  officers and directors are  exercisable
at prices  ranging from $2.38 to $5.62 per share.  The other  options  issued to
certain  employees of and  consultants to the Company are  exercisable at prices
ranging from $2.38 to $14.10 per share.

         Shares  issuable upon the exercise of options  granted to the Company's
officers and directors  pursuant to the Plans, as well as shares issued pursuant
to the Stock  Bonus Plan,  are being  offered by means of this  Prospectus.  The
following table provides certain information concerning the shareholdings of the
Company's  officers  and  directors  and the  shares  offered  by  means of this
Prospectus.

                                                       Number of Shares
                      Number of     Number of Shares   to be Beneficial-
  Name of              Shares        Being Offered     ly Owned on Com- Percent
  Selling            Beneficially   Bonus    Option    pletion of the      of
Shareholder            Owned      Shares(2) Shares(3)  Offering          Class
- ----------------     -----------  --------- ---------  --------------  --------
Maximilian de Clara        --         --   426,333              --        --
Geert R. Kersten      105,495 (1)    555   811,750         104,940         *
Patricia B. Prichep     3,348        318   118,000           3,030         *
M. Douglas Winship        438        438    67,000              --        --
Eyal Talor, Ph.D        1,909      1,909    73,500              --        --
Prem Sarin, Ph.D          376        376    68,500              --        --
Daniel Zimmerman, Ph.D 20,431        361    61,000          20,700         *
Mark V. Soresi         15,000         --   105,000          15,000         *
F. Donald  Hudson                     --   137,000              --        --

* Less than 1%.

(1) Includes  shares held in trusts for the benefit of Mr.  Kersten's  children.
(2) Represents shares issued as stock bonus. Of these, all but 1,500 shares were
issued,  in lieu of cash, as the Company's  matching  contribution to its 401(k)
pension plan.  (3)  Represents  shares issued or issuable upon exercise of stock
options.

         Mr.  de Clara and Mr.  Kersten  are  officers  and  directors  of the
Company.  Ms. Prichep,  Mr. Winship,  Dr. Talor,  Dr. Sarin and Dr.  Zimmerman
are officers of the Company.  Mr.  Soresi and Mr.  Hudson are directors of the
Company.

         Each Selling Shareholder has represented that the Shares were purchased
for investment and with no present  intention of  distributing or reselling such
Shares.  However,  in  recognition  of  the  fact  that  holders  of  restricted
securities may wish to be legally  permitted to sell their Shares when they deem
appropriate,  the Company has filed with the Commission under the Securities Act
of 1933 a Form S-8 registration  statement of which this Prospectus forms a part
with   respect  to  the  resale  of  the  Shares   from  time  to  time  in  the
over-the-counter market or in privately negotiated transactions.

<PAGE>  

       Certain of the Selling  Shareholders,  their  associates and affiliates
may from time to time be employees  of,  customers  of,  engage in  transactions
with,  and/or  perform  services  for the  Company  or its  subsidiaries  in the
ordinary course of business.


                                PLAN OF DISTRIBUTION
         The Selling Shareholders may sell the Shares offered by this Prospectus
from time to time in negotiated  transactions in the over-the-counter  market at
fixed prices which may be changed from time to time, at market prices prevailing
at the time of sale, at prices  related to such  prevailing  market prices or at
negotiated  prices.  The Selling  Shareholders  may effect such  transactions by
selling the Shares to or through  broker/dealers,  and such  broker/dealers  may
receive compensation in the form of discounts,  concessions, or commissions from
the  Selling  Shareholders  and/or the  purchasers  of the Shares for which such
broker/dealers may act as agent or to whom they may sell, as principal,  or both
(which  compensation  as to a  particular  broker/dealer  may  be in  excess  of
customary compensation).

         The Selling  Shareholders and any  broker/dealers who act in connection
with the sale of the Shares hereunder may be deemed to be "underwriters"  within
the meaning of  ss.2(11) of the  Securities  Acts of 1933,  and any  commissions
received  by them and profit on any resale of the Shares as  principal  might be
deemed to be underwriting  discounts and  commissions  under the Securities Act.
The Company has agreed to indemnify the Selling  Shareholders and any securities
broker/dealers who may be deemed to be underwriters against certain liabilities,
including liabilities under the Securities Act as underwriters or otherwise.

         The Company has  advised  the  Selling  Shareholders  that they and any
securities   broker/dealers  or  others  who  may  be  deemed  to  be  statutory
underwriters will be subject to the Prospectus  delivery  requirements under the
Securities  Act of 1933.  The Company has also advised each Selling  Shareholder
that in the  event  of a  "distribution"  of the  shares  owned  by the  Selling
Shareholder,  such Selling  Shareholder,  any "affiliated  purchasers",  and any
broker/  dealer or other person who  participates  in such  distribution  may be
subject to Rule 102 under the Securities Exchange Act of 1934 ("1934 Act") until
their  participation  in that  distribution is completed.  A  "distribution"  is
defined in Rule 102 as an offering of  securities  "that is  distinguished  from
ordinary trading  transactions by the magnitude of the offering and the presence
of special  selling efforts and selling  methods".  The Company has also advised
the  Selling  Shareholders  that  Rule 101  under  the 1934  Act  prohibits  any
"stabilizing bid" or "stabilizing  purchase" for the purpose of pegging,  fixing
or stabilizing the price of the Common Stock in connection with this offering.

                             DESCRIPTION OF COMMON STOCK

         The shares of Common Stock  offered by this  Prospectus  are fully paid
and  non-assessable.  Holders of the Common Stock do not have preemptive rights.
Each  stockholder is entitled to one vote for each share of Common stock held of
record by such stockholder.  There is no right to cumulate votes for election of
directors.  Upon liquidation of the Company,  the assets then legally  available
for  distribution  to holders of the Common  Stock will be  distributed  ratably
among such shareholders in proportion to their stock holdings. Holders of Common
Stock  are  entitled  to  dividends  when,  as and if  declared  by the Board of
Directors out of funds legally available therefor.

      
<PAGE>


                                GENERAL
         The  Company's  Bylaws  provide  that the Company  will  indemnify  its
directors and officers  against  expense and  liabilities  they incur to defend,
settle or satisfy any civil or criminal  action brought against them as a result
of their being or having been Company  directors or officers unless, in any such
action,  they have acted with gross negligence or willful  misconduct.  Officers
and Directors are not entitled to be indemnified for claims or losses  resulting
from a breach of their duty of loyalty to the Company, for acts or omissions not
in good faith or which involve intentional  misconduct or a knowing violation of
law or a  transaction  from  which the  director  derived an  improper  personal
benefit. Insofar as indemnification for liabilities arising under the Securities
Act of l933 may be  permitted  to the  Company's  directors  and  officers,  the
Company has been  informed  that in the opinion of the  Securities  and Exchange
Commission  such  indemnification  is against  public policy as expressed in the
Securities Act of l933, and is, therefore, unenforceable.

         No dealer,  salesman,  or any other person has been  authorized to give
any  information or to make any  representations  other than those  contained in
this  prospectus  in connection  with this offering and, if given or made,  such
information or representations must not be relied upon as having been authorized
by the Company or the selling shareholders.  This prospectus does not constitute
an offer to sell, or a solicitation of any offer to buy, the securities  offered
in any  jurisdiction  to any person to whom it is  unlawful  to make an offer or
solicitation.  Neither  the  delivery  of  this  prospectus  nor any  sale  made
hereunder shall, under any  circumstances,  create an implication that there has
not been any change in the affairs of the Company  since the date hereof or that
any  information  contained  herein is correct as to any time  subsequent to its
date.

         All  dealers  effecting  transactions  in  the  registered  securities,
whether or not participating in this distribution,  may be required to deliver a
prospectus.  This is an  addition  to the  obligation  of  dealers  to deliver a
prospectus  when  acting  as  underwriters  and with  respect  to  their  unsold
allotments or subscriptions.









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