CEL SCI CORP
S-8, 1999-11-12
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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 As filed with the Securities and Exchange Commission on November 11, 1999
                                Registration No.
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                    FORM S-8
                             REGISTRATION STATEMENT
                         UnderThe Securities Act of l933

                               CEL-SCI CORPORATION

               (Exact name of issuer as specified in its charter)

            Colorado                                   84-0916344
(State or other jurisdiction of                      (I.R.S. Employer
 incorporation or organization)                     Identification No.)

          8229 Boone Blvd., Suite 802                    22182
              Vienna, Virginia
   -------------------------------------------        -----------
   (Address of Principal Executive Offices)           (Zip Code)

                          Incentive Stock Option Plans
                        Non-Qualified Stock Option Plans
                                Stock Bonus Plans
                              (Full Title of Plan)

                                Geert R. Kersten
                               CEL-SCI Corporation
                           8229 Boone Blvd., Suite 802
                             Vienna, Virginia 22182
                     (Name and address of agent for service)

                                  (703) 506-9460
               (Telephone number, including area code, of agent for service)

 Copies of all  communications,  including  all  communications  sent to agent
 for service to:
                              William T. Hart, Esq.
                                 Hart & Trinen
                             l624 Washington Street
                             Denver, Colorado 8020
                                 (303) 839-0061


<PAGE>



                           CALCULATION OF REGISTRATION FEE
                                        Proposed       Proposed
Title of                                maximum         maximum
securities                Amount        offering       aggregate     Amount of
 to be                    to be          price         offering    registration
registered              registered(1)  per share(2)     price           fee
- -------------------------------------------------------------------------------

Common Stock Issuable     340,000         $2.44         $829,600     $231.00
Pursuant to Stock Bonus
Plans

- ------------------------------------------------------------------------------

(1) This  Registration  Statement also covers such additional  number of shares,
presently undeterminable,  as may become issuable under the Stock Bonus Plans in
the event of stock dividends,  stock splits,  recapitalizations or other changes
in the Company's common stock. The shares subject to this Registration Statement
are shares granted  pursuant to the Company's Stock Bonus Plans all of which may
be reoffered in accordance with the provisions of Form S-8.

(2) Varied, but not less than the fair market value on the date that the options
were or are granted.  Pursuant to Rule 457(g),  the  proposed  maximum  offering
price per share and proposed  maximum  aggregate  offering  price are based upon
closing price of the Company's common stock on November 9, 1999.


<PAGE>


                               CEL-SCI CORPORATION
              Cross Reference Sheet Required Pursuant to Rule 404

                                     PART I
                       INFORMATION REQUIRED IN PROSPECTUS

 (NOTE: Pursuant to instructions to Form S-8, the Prospectus described below is
                not filed with this Registration Statement.)

Item
 No.     Form S-8 Caption                             Caption in Prospectus

  1.     Plan Information

         (a)  General Plan Information         Stock Option and Bonus Plans

         (b)  Securities to be Offered         Stock Option and Bonus Plans

         (c)  Employees who may Participate    Stock Option and Bonus Plans
              in the Plan

         (d)  Purchase of Securities Pursuant  Stock Option and Bonus Plans
              to the Plan and Payment for
              Securities Offered

         (e)  Resale Restrictions              Resale of Shares by Affiliates

         (f)  Tax Effects of Plan              Stock Option and Bonus Plans
              Participation

         (g)  Investment of Funds              Not Applicable.

         (h)  Withdrawal from the Plan;        Other Information Regarding the
              Assignment of Interest           Plans

         (i)  Forfeitures and Penalties        Other Information Regarding the
                                               Plans

         (j)  Charges and Deductions and       Other Information Regarding the
              Liens Therefore                  Plans

  2.     Registrant Information and Employee   Available Information,
         Plan Annual Information               Documents Incorporated by
                                               Reference


<PAGE>


                                     PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 3 - Incorporation of Documents by Reference

The following  documents  filed by the Company with the  Securities and Exchange
Commission are incorporated by reference in this Registration Statement:  Annual
Report on Form l0-K for the year ending September 30, 1998, reports on Form 10-Q
for the quarters ending December 31, 1998,  March 31, 1999 and June 30, 1999 and
Proxy  Statement  relating to the  Company's  April 12,  1999 Annual  Meeting of
Shareholders.  All  reports  and  documents  subsequently  filed by the  Company
pursuant to Section 13(a),  13(c), 14 or 15(d) of the Securities Exchange Act of
1934,  prior to the filing of a  post-effective  amendment to this  Registration
Statement of which this Prospectus is a part which indicates that all securities
offered hereby have been sold or which deregisters all securities then remaining
unsold,  shall be deemed to be  incorporated by reference in this Prospectus and
to be a part thereof from the date of filing of such reports or documents.

Item 4 - Description of Securities

         Not required.

Item 5 - Interests of Named Experts and Counsel

         Not Applicable.

Item 6 - Indemnification of Directors and Officers

The Bylaws of the Company  provide in substance that the Company shall indemnify
any  person  who was or is a party  or is  threatened  to be made a party to any
threatened or completed  action,  suit or proceeding,  whether civil,  criminal,
administrative,  or  investigative  by reason of the fact that such person is or
was a director,  officer, employee,  fiduciary or agent of the Company, or is or
was  serving at the request of the  Company as a  director,  officer,  employee,
fiduciary or agent of another corporation,  partnership, joint venture, trust or
other enterprise, against expenses (including attorney's fees), judgments, fines
and amounts paid in settlement  actually and reasonably  incurred by such person
to the full  extent  permitted  by the laws of the state of  Colorado;  and that
expenses  incurred  in  defending  any such civil or  criminal  action,  suit or
proceeding  may be paid by the  Company in advance of the final  disposition  of
such action,  suit or  proceeding as authorized by the Board of Directors in the
specific case upon receipt of an  undertaking  by or on behalf of such director,
officer  or  employee  to repay  such  amount  to the  Company  unless  it shall
ultimately be determined  that such person is entitled to be  indemnified by the
Company as authorized in the Bylaws.



<PAGE>


Item 7 - Exemption from Registration Claimed

         In September 1999 the Company issued 200,000 shares of its common stock
to  Maximilian  de Clara,  an officer and director of the  Company.  The 200,000
shares were issued  pursuant to the Company's  Stock Bonus Plan. The issuance of
these  shares was  exempt  from  registration  pursuant  to section  4(2) of the
Securities Act of 1933.

Item 8 - Exhibits

  4    - Instruments Defining Rights of
         Security Holders                 -----------------

 (a) - Common Stock                     Incorporated by reference to Exhibit
                                        4(a) of the Company's Registration
                                        Statements  on  Form S-l, File Nos.
                                        2-85547-D and 33-7531.

 (b) - 1998 Stock Bonus Plan
       (as amended)                     __________________________________


  5 - Opinion Regarding Legality        __________________________________

 l5 - Letter Regarding Unaudited Interim
      Financial Information                None

 23 - Consent of Independent Public
      Accountants and Attorneys         __________________________________

 24 - Power of Attorney                 Included in the signature page
                                        of this Registration Statement

  99 - Additional Exhibits
    (Re-Offer Prospectus)               __________________________________

Item 9 - Undertakings

         (a)  The undersigned registrant hereby undertakes:

              (1) To file,  during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:

               (i)  to include any  prospectus  required by Section  l0(a)(3) of
                    the Securities Act of l933;

              (ii) to  reflect  in the  prospectus  any facts or events  arising
                   after the effective  date of the  registration  statement (or
                   the most  recent  post-effective  amendment  thereof)  which,
                   individually  or in the  aggregate,  represent a  fundamental
                   change  in the  information  set  forth  in the  registration
                   statement; and

              (iii)to include any material  information with respect to the plan
                   of distribution not previously  disclosed in the registration
                   statement or any material  change in such  information in the
                   registration statement;

                   Provided,  however,  that paragraphs (a)(l)(i) and (a)(l)(ii)
                   will not apply if the information  required to be included in
                   a  post-effective  amendment by those paragraphs is contained
                   in  periodic  reports  filed by the  registrant  pursuant  to
                   Section l3 or Section l5(d) of the Securities Act of l934

              (2) That, for the purpose of determining  any liability  under the
Securities Act of l933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

              (3) To  remove  from  registration  by means  of a  post-effective
amendment  any of the  securities  being  registered  which remain unsold at the
termination of the offering.

         (b) The undersigned  registrant hereby undertakes that, for purposes of
determining  any liability  under the Securities Act of l933, each filing of the
registrant's  Annual  Report  pursuant to Section  l3(a) or Section l5(d) of the
Securities  Exchange  Act of l934 (and,  where  applicable,  each  filing of any
employee  benefit  plan's  annual  report  pursuant  to  Section  l5(d)  of  the
Securities  Exchange  Act of l934)  that is  incorporated  by  reference  in the
registration  statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         (c)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities Act of 1933 may be permitted to directors,  officers and  controlling
persons of the registrant  pursuant to the foregoing  provisions,  or otherwise,
the  registrant  has been  advised  that in the  opinion of the  Securities  and
Exchange  Commission such  indemnification is against public policy as expressed
in the Act and is,  therefore,  unenforceable.  In the  event  that a claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.



<PAGE>


                                POWER OF ATTORNEY

      KNOW ALL MEN BY THESE PRESENTS,  that each of the undersigned  constitutes
and appoints  Maximilian  de Clara and Geert R. Kersten,  and each of them,  his
true and lawful  attorneys-in-fact  and agents,  with full power of substitution
and  resubstitution,  for him and in his name,  place and stead,  in any and all
capacities, to sign any and all amendments (including post-effective amendments)
to this Registration Statement, and to file the same, with all exhibits thereto,
and all  other  documents  in  connection  therewith,  with the  Securities  and
Exchange Commission granting unto said  attorneys-in-fact  and agents full power
and  authority  to do and  perform  each and every act and thing  requisite  and
necessary to be done,  as fully to all intents and purposes as he might or could
do in person,  hereby  ratifying and confirming all that said  attorneys-in-fact
and agents or their  substitutes  or  substitute  may lawfully do or cause to be
done by virtue hereof.

                                   SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  l933,  the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in Vienna, State of Virginia, on November 9, 1999.

                                       CEL-SCI CORPORATION

                                       By:  /s/ Maximilian de Clara
                                          MAXIMILIAN DE CLARA, PRESIDENT

         Pursuant  to the  requirements  of the  Securities  Act of  l933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

Signature                               Title                      Date

 /s/ Maximilian de Clara         Director and President     November 9, 1999
 -------------------------
 Maxamilian de Clara


 /s/ Geert R. Kersten            Director, Principal        November 9, 1999
- -------------------------        Financial Officer and
Geert R. Kersten                 Chief Executive Officer


- ----------------------           Director
Alexaner G. Esterhazy


 /s/ John M. Jacquemin           Director                   November 9, 1999
- -------------------------
 John M. Jacquemin

<PAGE>



                                    FORM S-8
                              CEL-SCI Corporation
                                8229 Boone Blvd.
                                    Suite 802
                             Vienna, Virginia 22182


                                    EXHIBITS


<PAGE>





Exhibits

 4  - Instruments Defining Rights of
      Security Holders                      ---------------------------------

(a) - Common Stock                          Incorporated by reference to Exhibit
                                            4(a) of the Company's Registration
                                            Statements on Form S-l, File Nos.
                                            2-85547-D and 33-7531.

(b) - 1998 Stock Bonus Plan (as amended)    _________________________________

 5 - Opinion Regarding Legality             _________________________________

l5 - Letter Regarding Unaudited Interim
    Financial Information                   None

23 - Consent of Independent Public
        Accountants and Attorneys          __________________________________

24 - Power of Attorney                     Included in the signature page
                                           of this Registration Statement

99  - Additional Exhibits
      (Re-Offer Prospectus)                __________________________________




                               CEL-SCI CORPORATION
                              1998 STOCK BONUS PLAN


         l.  Purpose.  The purpose of this Plan is to advance the  interests  of
Cel-Sci  Corporation  (the "Company") and its  shareholders,  by encouraging and
enabling selected officers, directors,  consultants and key employees upon whose
judgment,  initiative  and effort  the  Company  is  largely  dependent  for the
successful conduct of its business, to acquire and retain a proprietary interest
in the Company by ownership of its stock,  to keep  personnel of experience  and
ability  in the  employ  of  the  Company  and  to  compensate  them  for  their
contributions  to the growth and profits of the Company and thereby  induce them
to continue to make such contributions in the future.

         2.   Definitions.

              A.   "Board" shall mean the board of directors of the Company.

              B.   "Committee" means the directors duly appointed to administer
                    the Plan.

              C.   "Plan" shall mean this Stock Bonus Plan.

              D.  "Bonus  Share"  shall mean the  shares of common  stock of the
Company  reserved  pursuant to Section 4 hereof and any such shares  issued to a
Recipient pursuant to this Plan.

              E. "Recipient"  shall mean any individual  rendering  services for
 the Company to whom shares are granted pursuant to this Plan.

          3.  Administration  of Plan.  The  Plan  shall  be  administered  by a
     committee   of  two  or  more   directors   appointed  by  the  Board  (the
     "Committee").  The  Committee  shall  report all action  taken by it to the
     Board. The Committee shall have full and final authority in its discretion,
     subject to the provisions of the Plan, to determine the individuals to whom
     and the time or times at which Bonus Shares shall be granted and the number
     of Bonus Shares;  to construe and interpret the Plan; and to make all other
     determinations and take all other actions deemed necessary or advisable for
     the proper  administration of the Plan. All such actions and determinations
     shall be conclusively binding for all purposes and upon all persons.

          4. Bonus  Share  Reserve.  There  shall be  established  a Bonus Share
     Reserve to which shall be credited  300,000 shares of the Company's  common
     stock.  In the event that the shares of common stock of the Company should,
     as a result of a stock split or stock  dividend or combination of shares or
     any other change,  or exchange for other  securities  by  reclassification,
     reorganization,  merger,  consolidation,  recapitalization or otherwise, be
     increased or decreased or changed into or exchanged for, a different number
     or kind of shares of stock or other securities of the Company or of another
     corporation, the number of shares then remaining in the Bonus Share Reserve
     shall be appropriately  adjusted to reflect such action.  Upon the grant of
     shares hereunder,  this reserve shall be reduced by the number of shares so
     granted.  Distributions  of Bonus Shares may, as the Committee shall in its
     sole discretion  determine,  be made from authorized but unissued shares or
     from treasury  shares.  All authorized and unissued  shares issued as Bonus
     Shares in  accordance  with the Plan shall be fully paid and  nonassessable
     and free from preemptive rights.


<PAGE>

          5. Eligibility, and Granting and Vesting of Bonus Shares. Bonus Shares
     may be granted  under the Plan to the  Company's  employees,  directors and
     officers, and consultants or advisors to the Company, provided however that
     bona fide services  shall be rendered by such  consultants  or advisors and
     such  services  must  not be in  connection  with  the  offer  or  sale  of
     securities in a  capital-raising  transaction.  The Committee,  in its sole
     discretion,  is empowered to grant to an eligible  Participant  a number of
     Bonus Shares as it shall  determine from time to time.  Each grant of these
     Bonus Shares shall become vested  according to a schedule to be established
     by the Committee  directors at the time of the grant.  For purposes of this
     plan,  vesting shall mean the period during which the recipient must remain
     an  employee  or  provide  services  for the  Company.  At such time as the
     employment  of the Recipient  ceases,  any shares not fully vested shall be
     forfeited  by the  Recipient  and  shall be  returned  to the  Bonus  Share
     Reserve.   The  Committee,   in  its  sole  discretion,   may  also  impose
     restrictions  on the  future  transferability  of the bonus  shares,  which
     restrictions shall be set forth on the notification to the Recipient of the
     grant.

     The aggregate  number of Bonus Shares which may be granted pursuant to this
     Plan shall not exceed the amount  available  therefore in the Bonus Share
     Reserve.

          6. Form of Grants. Each grant shall specify the number of Bonus Shares
     subject thereto, subject to the provisions of Section 5 hereof.

          At the time of making  any  grant,  the  Committee  shall  advise  the
     Recipient  by delivery of written  notice,  in the form of Exhibit A hereto
     annexed.

          7. Recipients' Representations.

          A. The Committee may require that, in acquiring any Bonus Shares,  the
     Recipient  agree with,  and represent to, the Company that the Recipient is
     acquiring  such Bonus  Shares for the  purpose  of  investment  and with no
     present  intention to transfer,  sell or otherwise dispose of shares except
     such distribution by a legal representative as shall be required by will or
     the laws of any  jurisdiction  in winding-up  the estate of any  Recipient.
     Such shares shall be transferable  thereafter only if the proposed transfer
     shall be permissible pursuant to the Plan and if, in the opinion of counsel
     (who shall be satisfactory  to the Committee),  such transfer shall at such
     time be in compliance  with  applicable  securities  laws.

<PAGE>

          B. To effectuate Paragraph A above, the Recipient shall deliver to the
     Committee,  in duplicate, an agreement in writing, signed by the Recipient,
     in form and  substance  as set forth in Exhibit B hereto  annexed,  and the
     Committee shall forthwith  acknowledge its receipt thereof.

          8. Restrictions Upon Issuance.

          A.   Bonus   Shares   shall   forthwith   after  the   making  of  any
     representations  required by Section 6 hereof, or if no representations are
     required then within thirty (30) days of the date of grant,  be duly issued
     and transferred and a certificate or certificates  for such shares shall be
     issued  in  the  Recipient's  name.  The  Recipient  shall  thereupon  be a
     shareholder with respect to all the shares  represented by such certificate
     or certificates, shall have all the rights of a shareholder with respect to
     all such shares, including the right to vote such shares and to receive all
     dividends  and other  distributions  (subject to the  provisions of Section
     7(B)  hereof)  paid with  respect  to such  shares.  Certificates  of stock
     representing  Bonus Shares  shall be imprinted  with a legend to the effect
     that the shares  represented  thereby are subject to the provisions of this
     Agreement,  and to the vesting and transfer limitations  established by the
     Committee, and each transfer agent for the common stock shall be instructed
     to like effect with  respect of such shares.

          B. In the event that, as the result of a stock split or stock dividend
     or  combination  of shares  or any  other  change,  or  exchange  for other
     securities,  by reclassification,  reorganization,  merger,  consolidation,
     recapitalization  or otherwise,  the Recipient shall, as owner of the Bonus
     Shares subject to restrictions  hereunder, be entitled to new or additional
     or different shares of stock or securities, the certificate or certificates
     for, or other  evidences of, such new or additional or different  shares or
     securities,  together  with a stock power or other  instrument  of transfer
     appropriately  endorsed,  shall also be imprinted with a legend as provided
     in Section 7(A),  and all  provisions of the Plan relating to  restrictions
     herein set forth shall thereupon be applicable to such new or additional or
     different shares or securities to the extent  applicable to the shares with
     respect to which they were distributed.

          C. The grant of any Bonus  Shares  shall be subject  to the  condition
     that if at any time the Company shall  determine in its discretion that the
     satisfaction of withholding tax or other withholding  liabilities,  or that
     the listing,  registration,  or qualification of any Bonus Shares upon such
     exercise upon any securities exchange or under any state or federal law, or
     that the  consent or approval  of any  regulatory  body,  is  necessary  or
     desirable as a condition  of, or in  connection  with,  the issuance of any
     Bonus Shares,  then in any such event, such exercise shall not be effective
     unless such withholding, listing, registration,  qualification, consent, or
     approval  shall have been effected or obtained free of any  conditions  not
     acceptable to the Company.

<PAGE>

          D. Unless the Bonus  Shares  covered by the Plan have been  registered
     with the  Securities and Exchange  Commission  pursuant to Section 5 of the
     Securities Act of l933,  each Recipient  shall, by accepting a Bonus Share,
     represent and agree, for himself and his transferees by will or the laws of
     descent  and  distribution,   that  all  Bonus  Shares  were  acquired  for
     investment  and not for resale or  distribution.  Upon such exercise of any
     portion of an option,  the person entitled to exercise the same shall, upon
     request of the Committee,  furnish  evidence  satisfactory to the Committee
     (including  a written  and signed  representation)  to the effect  that the
     shares of stock are being acquired in good faith for investment and not for
     resale  or  distribution.  Furthermore,  the  Committee  may,  if it  deems
     appropriate,  affix a legend  to  certificates  representing  Bonus  Shares
     indicating  that  such  Bonus  Shares  have  not been  registered  with the
     Securities and Exchange Commission and may so notify the Company's transfer
     agent.  Such  shares may be disposed  of by a  Recipient  in the  following
     manner only: (l) pursuant to an effective  registration  statement covering
     such  resale or  reoffer,  (2)  pursuant to an  applicable  exemption  from
     registration as indicated in a written opinion of counsel acceptable to the
     Company,  or (3) in a transaction  that meets all the  requirements of Rule
     l44 of the Securities and Exchange  Commission.  If Bonus Shares covered by
     the Plan have been registered with the Securities and Exchange  Commission,
     no  such  restrictions  on  resale  shall  apply,  except  in the  case  of
     Recipients who are directors,  officers,  or principal  shareholders of the
     Company.  Such  persons  may  dispose  of  shares  only by one of the three
     aforesaid methods.

         9.  Limitations.  Neither the action of the Company in establishing the
Plan,  nor any action taken by it nor by the Committee  under the Plan,  nor any
provision  of the Plan,  shall be construed as giving to any person the right to
be retained in the employ of the Company.

              Every  right of action by or on  behalf of the  Company  or by any
shareholder  against  any past,  present or future  member of the Board,  or any
officer or  employee of the Company  arising out of or in  connection  with this
Plan  shall,  irrespective  of  the  place  where  action  may  be  brought  and
irrespective of the place of residence of any such director, officer or employee
cease and be barred by the expiration of one year from whichever is the later of
(a) the date of the act or  omission  in  respect  of which such right of action
arises; or (b) the first date upon which there has been made generally available
to  shareholders  an annual report of the Company or any proxy statement for the
annual  meeting of  shareholders  following the issuance of such annual  report,
which annual  report and proxy  statement  alone or together set forth,  for the
related  period,  the number of shares issued pursuant to this Plan; and any and
all right of action by any  employee  (past,  present  or  future)  against  the
Company  arising out of or in connection  with this Plan shall,  irrespective of
the place where action may be brought,  cease and be barred by the expiration of
one year from the date of the act or  omission in respect of which such right of
action arises.

         l0.  Amendment,  Suspension or  Termination  of the Plan.  The Board of
Directors may alter,  suspend, or discontinue the Plan, but may not, without the
approval of a majority of those holders of the Company's  Common Stock voting in
person  or by proxy  at any  meeting  of the  Company's  shareholders,  make any
alteration  or amendment  thereof which  operates to (a) abolish the  Committee,
change the qualification of its members,  or withdraw the  administration of the
Plan from its supervision, (b) make any material change in the class of eligible
employees  as defined in  paragraph  5, (c)  increase the total number of shares
reserved for purposes of this Plan except as provided in paragraph 4, (d) extend
the term of the Plan or,  (e)  materially  increase  the  benefits  accruing  to
persons participating under this Plan.

<PAGE>

         Unless the Plan shall  theretofore  have been  terminated by the Board,
the Plan shall  terminate  ten years after the  effective  date of the Plan.  No
Bonus Share may be granted during any suspension or after the termination of the
Plan. No amendment,  suspension,  or  termination  of the Plan shall,  without a
recipient's consent,  alter or impair any of the rights or obligations under any
Bonus Share theretofore granted to such recipient under the Plan.

       ll. Governing Law. The Plan shall be governed by the laws of the State
 of Colorado.

          l2. Expenses of Administration. All costs and expenses incurred in the
 operation and administration of this Plan shall be borne by the Company.


                                  CEL-SCI CORPORATION



                                  By _____________________________


<PAGE>


                                  - EXHIBIT A -
                              CEL-SCI CORPORATION
                                STOCK BONUS PLAN

         TO:  Recipient:

          PLEASE BE ADVISED  that  CEL-SCI  Corporation  has on the date  hereof
     granted to the  Recipient the number of Bonus Shares as set forth under and
     pursuant to the Stock Bonus Plan. Before these shares are to be issued, the
     Recipient  must deliver to the Committee that  administers  the Stock Bonus
     Plan an agreement in duplicate,  in the form as Exhibit B hereto. The Bonus
     Shares  are  issued   subject  to  the   following   vesting  and  transfer
     limitations.

         Vesting:

         Number of Shares                   Date of Vesting



         Transfer Limitations:



                                       CEL-SCI CORPORATION


                                       By ____________________________
  Date ____________________


<PAGE>


                                  - EXHIBIT B -


CEL-SCI Corporatio
8229 Boone Blvd., Suite 802
Vienna,  Virginia  22182


Gentlemen:

          I represent and agree that said Bonus Shares are being  acquired by me
     for  investment and that I have no present  intention to transfer,  sell or
     otherwise dispose of such shares,  except as permitted pursuant to the Plan
     and in compliance with applicable  securities  laws, and agree further that
     said shares are being acquired by me in accordance  with and subject to the
     terms,  provisions  and  conditions  of said Plan, to all of which I hereby
     expressly  assent.  These agreements shall bind and inure to the benefit of
     my heirs,  legal  representatives,  successors  and assigns.

               My address of record is:


               and my social security number:

                                             Very truly yours,




Receipt of the above is hereby acknowledged.

                                             CEL-SCI CORPORATION



     __________                             By _____________________
       Date                                its __________________






                                November 10, 1999



CEL-SCI Corporation
8229 Boone Blvd., Suite 802
Vienna,  Virginia 22182


 Gentlemen:

          This letter will  constitute  an opinion upon the legality of the sale
 by CEL-SCI Corporation, a Colorado corporation,  of up to 340,000 shares of
 Common Stock, all as referred to in the Registration  Statement on Form S-8
 filed by the Company with the Securities and Exchange Commission.

         We have  examined  the  Articles of  Incorporation,  the Bylaws and the
minutes of the Board of Directors of the Company and the applicable  laws of the
State of Colorado, and a copy of the Registration Statement. In our opinion, the
Company has duly  authorized the issuance of the shares of stock mentioned above
and  such  shares  when  issued  will  be  legally   issued,   fully  paid,  and
nonassessable.

                                  Very truly yours,

                                  HART & TRINEN


                                  By  /s/ William T. Hart
                                       William T. Hart





INDEPENDENT AUDITORS' CONSENT

     We consent to the incorporation by reference in this Registration Statement
     of CEL-SCI  CORPORATION  on Form S-8 of our report dated December 11, 1998,
     appearing in the Annual Report on Form 10-K of CEL-SCI  CORPORATION for the
     year ended September 30, 1998.


DELOITTE & TOUCHE LLP
Mclean, Virginia

November 8, 1999


<PAGE>


                              CONSENT OF ATTORNEYS


          Reference is made to the Registration Statement of CEL-SCI Corporation
     on Form S-8  whereby the Company  proposes  to sell  340,000  shares of the
     Company's Common Stock. Reference is also made to Exhibit 5 included in the
     Registration  Statement relating to the validity of the securities proposed
     to be  issued  and  sold.  We  hereby  consent  to the  use of our  opinion
     concerning the validity of the securities proposed to be issued and sold.

                                    Very Truly Yours,

                                    HART & TRINEN, L.L.P.




                                    By  /s/ William T. Hart
                                        William T. Hart

Denver, Colorado
November 9, 1999







                               CEL-SCI CORPORATION

                                  Common Stock

THESE SECURITIES INVOLVE A HIGH DEGREE OF RISK. SEE "RISK FACTORS".

         THESE   SECURITIES  HAVE  NOT  BEEN  APPROVED  OR  DISAPPROVED  BY  THE
SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES  COMMISSION,  NOR HAS
THE COMMISSION OR ANY STATE  SECURITIES  COMMISSION  PASSED UPON THE ACCURACY OR
ADEQUACY OF THIS PROSPECTUS.  ANY  REPRESENTATION  TO THE CONTRARY IS A CRIMINAL
OFFENSE.

         This  Prospectus  relates to shares (the "Shares") of common stock (the
"Common  Stock")  of CEL-SCI  Corporation  (the  "Company")  which may be issued
pursuant  to  certain  employee  incentive  plans  adopted by the  Company.  The
employee  incentive  plans provide for the grant,  to selected  employees of the
Company and other persons, of either stock bonuses or options to purchase shares
of the Company's Common Stock. Persons who received Shares pursuant to the Plans
and who are offering such Shares to the public by means of this  Prospectus  are
referred to as the "Selling Shareholders".

         The Company has  Incentive  Stock  Option  Plans,  Non-Qualified  Stock
Option Plans and Stock Bonus Plans.  In some cases the plans described above are
collectively  referred to as the "Plans".  The terms and conditions of any stock
bonus and the terms and  conditions  of any options,  including the price of the
shares of Common Stock issuable on the exercise of options,  are governed by the
provisions  of the  respective  Plans  and  the  stock  bonus  or  stock  option
agreements between the Company and the Plan participants.

         The  Selling  Shareholders  may offer the  shares  from time to time in
negotiated  transactions in the  over-the-counter  market, at fixed prices which
may be changed from time to time,  at market  prices  prevailing  at the time of
sale,  at prices  related  to such  prevailing  market  prices or at  negotiated
prices.  The Selling  Shareholders  may effect such  transactions by selling the
Shares to or through  securities  broker/dealers,  and such  broker/dealers  may
receive compensation in the form of discounts,  concessions, or commissions from
the  Selling  Shareholders  and/or  the  purchasers  of the Shares for whom such
broker/dealers  may act as  agent or to whom  they  sell as  principal,  or both
(which  compensation  as to a  particular  broker/dealer  might be in  excess of
customary commissions). See "Selling Shareholders" and "Plan of Distribution".

         None of the  proceeds  from  the  sale  of the  Shares  by the  Selling
Shareholders will be received by the Company. The Company has agreed to bear all
expenses (other than underwriting  discounts,  selling  commissions and fees and
expenses of counsel and other advisers to the Selling Shareholders). The Company
has agreed to indemnify the Selling  Shareholders  against certain  liabilities,
including  liabilities  under  the  Securities  Act of  1933,  as  amended  (the
"Securities Act").


                 The date of this Prospectus is ________, 1999.

<PAGE>

                              AVAILABLE INFORMATION

         The  Company  is  subject  to  the  information   requirements  of  the
Securities  Exchange  Act  of  1934  (the  "Exchange  Act")  and  in  accordance
therewith,  files reports and other information with the Securities and Exchange
Commission (the "Commission").  Proxy statements,  reports and other information
concerning  the  Company  can be  inspected  and  copied  at  Room  1024  of the
Commission's office at 450 Fifth Street, N.W.,  Washington,  D.C. 20549, and the
Commission's Regional Offices in New York (7 World Trade Center, Suite l300, New
York, New York 10048), and Chicago (Northwestern Atrium Center, 500 West Madison
Street, Suite 1400, Chicago,  Illinois 60661-2511),  and copies of such material
can be obtained from the Public Reference Section of the Commission at 450 Fifth
Street, N.W.,  Washington,  D.C. 20549, at prescribed rates. Certain information
concerning the Company is also available at the Internet Web Site  maintained by
the Securities and Exchange Commission at www.sec.gov.  This Prospectus does not
contain all  information set forth in the  Registration  Statement of which this
Prospectus  forms a part and exhibits  thereto  which the Company has filed with
the Commission under the Securities Act and to which reference is hereby made.

                       DOCUMENTS INCORPORATED BY REFERENCE

         The Company will provide, without charge, to each person to whom a copy
of this  Prospectus  is  delivered,  including any  beneficial  owner,  upon the
written or oral  request of such person,  a copy of any or all of the  documents
incorporated by reference herein (other than exhibits to such documents,  unless
such exhibits are specifically  incorporated by reference into this Prospectus).
Requests should be directed to:

                               CEL-SCI Corporation
                           8229 Boone Blvd., Suite 802
                             Vienna, Virginia 223l4
                                 (703) 506-9460
                              Attention: Secretary

         The  following  documents  filed  with the  Commission  by the  Company
(Commission  File No.  0-11503) are hereby  incorporated  by reference into this
Prospectus:

         (1) The Company's  Annual Report on Form 10-K for the fiscal year ended
September 30, 1998; and

         (2) The Company's  reports on Form 10-Q for the quarters ended December
31, 1998, March 31, 1999 and June 30, 1999.

         (3)  Proxy Statement relating to the April 12, 1999 Meeting of
 Shareholders.

         All  documents  filed with the  Commission  by the Company  pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the date of
this Prospectus and prior to the termination of the offering  registered  hereby
shall be deemed to be incorporated by reference into this Prospectus and to be a
part  hereof  from the  date of the  filing  of such  documents.  Any  statement
contained in a document  incorporated  or deemed to be incorporated by reference
herein  shall be deemed to be modified or  superseded  for the  purposes of this

<PAGE>



Prospectus  to  the  extent  that  a  statement   contained  herein  or  in  any
subsequently  filed  document which also is or is deemed to be  incorporated  by
reference  herein  modifies or  supersedes  such  statement.  Such  statement so
modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this Prospectus.



<PAGE>


                                TABLE OF CONTENTS
                                                                        PAGE


THE COMPANY ..........................................................    6

DILUTION AND COMPARATIVE SHARE DATA ..................................    9

USE OF PROCEEDS ......................................................   11

SELLING SHAREHOLDERS .................................................   11

PLAN OF DISTRIBUTION .................................................   14

DESCRIPTION OF COMMON STOCK ..........................................   14

GENERAL ..............................................................   15



<PAGE>


                                   THE COMPANY

         CEL-SCI Corporation was formed as a Colorado corporation in 1983 and is
involved in the research and  development  of certain  drugs and  vaccines.  The
Company's  first  product,  Multikine(TM),   manufactured  using  the  Company's
proprietary  cell culture  technologies,  is a combination,  or  "cocktail",  of
natural human  interleukin-2  ("IL-2") and certain  lymphokines  and  cytokines.
Multikine is being  tested to  determine  if it is  effective  in improving  the
immune response of cancer  patients.  The Company's second product,  HGP-30,  is
being tested by the Company's wholly-owned subsidiary, Viral Technologies,  Inc.
to determine if it is an effective vaccine/treatment against the AIDS virus. The
third technology the Company is developing,  L.E.A.P.S.  (Ligand Epitope Antigen
Presentation  System)  is a T-cell  modulation  technology  which can be used to
direct a  specific  immune  response  and which is  thought  to be  particularly
important in the case of diseases  which have no approved  vaccinations  such as
herpes  simplex,  malaria,  and  AIDS.  The  Company  intends  to use  this  new
technology to improve the cellular  immune  response of persons  vaccinated with
HGP-30 and to develop  potential  treatments  and/or  vaccines  against  various
diseases.   Present  target  diseases  are  AIDS,   herpes   simplex,   malaria,
tuberculosis, prostate cancer and breast cancer.

         Before  human  testing can begin with  respect to a drug or  biological
product,  pre-clinical  studies are conducted in laboratory  animals to evaluate
the  potential  efficacy  and the safety of a product.  Human  clinical  studies
generally involve a three-phase process. The initial clinical evaluation,  Phase
I,  consists of  administering  the  product and testing for safe and  tolerable
dosage levels.  Phase II trials  continue the evaluation of safety and determine
the appropriate dosage for the product, identify possible side effects and risks
in a larger group of subjects, and provide preliminary  indications of efficacy.
Phase III trials  consist of testing  for  actual  clinical  efficacy  within an
expanded group of patients at geographically dispersed test sites.

         The costs associated with the clinical trials relating to the Company's
technologies,  research expenditures and the Company's  administrative  expenses
have been funded with the public and  private  sales of shares of the  Company's
Common Stock and  borrowings  from third  parties,  including  affiliates of the
Company.

         The Company does not expect to develop commercial  products for several
years, if at all. The Company has had operating losses since its inception,  had
an  accumulated  deficit of  approximately  $50,461,000  at June 30,  1999,  and
expects to incur substantial losses for the foreseeable future.

    The  Company's  executive  offices  are located at 8229 Boone  Blvd.,  #802,
Vienna, Virginia 22182, and its telephone number is (703) 506-9460.

         As of September 15, 1999 the Company had  16,985,294  shares of Common
 Stock issued and outstanding.



<PAGE>


                                  RISK FACTORS

         Investors  should be aware that this offering  involves  certain risks,
including those described below, which could adversely affect the value of their
holdings of Common Stock.  The Company does not make,  nor has it authorized any
other person to make,  any  representation  about the future market value of the
Company's Common Stock. In addition to the other  information  contained in this
Prospectus,  the following factors should be considered  carefully in evaluating
an investment in the shares offered by this Prospectus

The Company Has Earned Only Limited Revenues and Has a History of Losses.

         The Company has had only limited  revenues since it was formed in 1983.
Since the date of its formation  and through June 30, 1999 the Company  incurred
net losses of  approximately  $50,461,000.  During the years ended September 30,
1996, 1997 and 1998 the Company  suffered  losses of $6,326,666,  $8,189,458 and
$6,442,683 respectively. The Company has relied principally upon the proceeds of
public and private sales of securities to finance its activities to date. All of
the Company's potential products are in the early stages of development, and any
commercial  sale of these  products  will be many years away.  Accordingly,  the
Company expects to incur substantial losses for the foreseeable future.

         There  can be no  assurance  the  Company  will be  profitable.  At the
present  time,  the  Company  intends  to use  available  funds to  finance  the
Company's operations.  Accordingly,  while payment of dividends rests within the
discretion  of the Board of  Directors,  no  common  stock  dividends  have been
declared or paid by the Company.  The Company does not  presently  intend to pay
dividends on its common  stock and there can be no  assurance  that common stock
dividends will ever be paid.

The Company Needs Additional Capital to Finance Its Operations.

         Clinical and other studies  necessary to obtain  approval of a new drug
can be time consuming and costly,  especially in the United States,  but also in
foreign countries.  The different steps necessary to obtain regulatory approval,
especially that of the Food and Drug Administration ("FDA"), involve significant
costs and may require  several  years to complete.  The Company  expects that it
will need additional  financing over an extended period of time in order to fund
the  costs  of  future  clinical  trials,  related  research,  and  general  and
administrative  expenses.  The  Company  may be  forced  to  delay  or  postpone
development  and  research  expenditures  if the  Company  is  unable  to secure
adequate  sources  of funds.  These  delays in  development  may have an adverse
effect on the  Company's  ability to produce a timely and  competitive  product.
There can be no  assurance  that the Company  will be able to obtain  additional
funding from other sources.

Cost Estimates for Clinical Trials and Research May be Inaccurate.

         The Company's  estimates of the costs  associated  with future clinical
trials and  research may be  substantially  lower than the actual costs of these
activities. If the Company's cost estimates are incorrect, the Company will need
additional funding for its research efforts.

<PAGE>

Products Which May Be Developed by the Company Will Require Regulatory Approval
 Prior to Sale.

         Therapeutic  agents,  drugs and  diagnostic  products  are  subject  to
approval,  prior to general  marketing,  by the FDA in the United  States and by
comparable agencies in most foreign countries.  The process of obtaining FDA and
corresponding  foreign approvals is costly and time consuming,  particularly for
pharmaceutical products such as those which might ultimately be developed by the
Company, VTI or its licensees, and there can be no assurance that such approvals
will be granted.  Any failure to obtain or any delay in obtaining such approvals
may  adversely  affect the  ability of  potential  licensees  or the  Company to
successfully  market  any  products  developed.  Also,  the  extent  of  adverse
government   regulations   which  might  arise  from   future   legislative   or
administrative action cannot be predicted.

The Company is Dependent on an Unrelated Corporation to Manufacture Multikine

          The Company has an  agreement  with an unrelated  corporation  for the
production,  until August 2000, of Multikine for research and testing  purposes.
At present, this is the Company's only source of Multikine.  If this corporation
could not,  for any  reason,  supply the  Company  with  Multikine,  the Company
estimates that it would take  approximately six to ten months to obtain supplies
of Multikine under an alternative  manufacturing  arrangement.  The Company does
not know what cost it would incur to obtain this alternative source of supply.

The  Biomedical  Feld in Which the Company is Involved is  Undergoing  Rapid and
Significant Technological Change.

         The  successful   development  of  therapeutic  agents  and  diagnostic
products from the compounds, compositions and processes licensed to the Company,
through  Company  financed  research  or  as  a  result  of  possible  licensing
arrangements with pharmaceutical or other companies,  will depend on its ability
to be in the  technological  forefront of this field.  There can be no assurance
that the Company will achieve or maintain  such a  competitive  position or that
other  technological  developments  will not  cause  the  Company's  proprietary
technologies to become uneconomical or obsolete.

The Company's Patents Might Not Protect the Company's Technology.

         Certain aspects of the Company's  technologies  are covered by U.S. and
foreign patents.  In addition,  the Company has a number of patent  applications
pending.  There is no assurance that the applications still pending or which may
be filed in the future will result in the issuance of any patents.  Furthermore,
there is no  assurance  as to the  breadth and degree of  protection  any issued
patents  might  afford the Company.  Disputes may arise  between the Company and
others as to the scope and  validity of these or other  patents.  Any defense of
the patents could prove costly and time  consuming and there can be no assurance
that the Company will be in a position,  or will deem it advisable,  to carry on
such a defense. Other private and public concerns,  including universities,  may
have filed  applications for, or may have been issued,  patents and are expected

<PAGE>


to  obtain  additional  patents  and  other  proprietary  rights  to  technology
potentially  useful or necessary to the Company.  The scope and validity of such
patents, if any, the extent to which the Company may wish or need to acquire the
rights  to such  patents,  and the  cost and  availability  of such  rights  are
presently  unknown.   Also,  as  far  as  the  Company  relies  upon  unpatented
proprietary  technology,  there is no  assurance  that others may not acquire or
independently  develop  the same or  similar  technology.  The  Company's  first
MULTIKINE  patent will expire in the year 2000.  Since the Company does not know
if it will ever be able to sell  MULTIKINE  on a commercial  basis,  the Company
cannot  predict  what  effect the  expiration  of this  patent  will have on the
Company.  Notwithstanding the above, the Company believes that trade secrets and
later issued patents will protect the technology  associated with Multikine past
the year 2000.

The Company's Product Liability Insurance May Not Be Adequate.

         Although the Company has product liability  insurance for Multikine and
its HGP-30  vaccine,  the  successful  prosecution  of a product  liability case
against the Company could have a materially  adverse effect upon its business if
the amount of any judgment exceeds the Company's insurance coverage.

The Loss of Management and Scientific Personnel Could Adversly Affect the
Company.

          The Company is dependent for its success on the continued availability
of its  executive  officers.  The loss of the  services of any of the  Company's
executive officers could have an adverse effect on the Company's  business.  The
Company  does not  carry  key man life  insurance  on any of its  officers.  The
Company's future success will also depend upon its ability to attract and retain
qualified scientific personnel.  There can be no assurance that the Company will
be able to hire and retain such necessary personnel.

Shares  Issuable  Upon the  Conversion  of  Options,  Warrants  and  Convertible
Securities May Depress the Price of the Company's Common Stock.

         The Company has issued  options to its officers,  directors,  employees
and  consultants  which  allow the holders to acquire  additional  shares of the
Company's  Common  Stock.  In some cases the  Company  has agreed  that,  at its
expense,  it will make  appropriate  filings  with the  Securities  and Exchange
Commission so that the securities issuable upon the exercise of the options will
be available for public sale.  Such filings could result in substantial  expense
to the Company and could hinder future financings by the Company.

         Until the options  expire,  the  holders  will have an  opportunity  to
profit  from any  increase in the market  price of the  Company's  Common  Stock
without  assuming  the risks of  ownership.  Holders of the options may exercise
them at a time when the Company  could obtain  additional  capital on terms more
favorable than those  provided by the options.  The exercise of the options will
dilute the voting interest of the owners of presently  outstanding shares of the
Company's  Common Stock and may  adversely  affect the ability of the Company to
obtain additional  capital in the future. The sale of the shares of Common Stock
issuable  upon the  exercise of the options  could  adversely  affect the market
price of the Company's stock.

<PAGE>

         In addition,  in  connection  with the sale of the  Company's  Series D
Preferred  Stock,  the  Company  issued  Series A and  Series B  Warrants  which
collectively  allow for the purchase of 1,100,000 shares of the Company's common
stock. See "Comparative Share Data".

         The  issuance  of common  stock  upon the  exercise  of the Series A or
Series B Warrants,  as well as future sales of such common stock or of shares of
common stock held by existing  stockholders,  or the perception  that such sales
could occur,  could  adversely  affect the market price of the Company's  common
stock.

Competition in the Research, Development and Commercialization of Products Which
May be Used in the Prevention or Treatment of Cancer and AIDS is Intense.

         Major  pharmaceutical  and chemical  companies,  as well as specialized
genetic engineering firms, are developing  products for these diseases.  Many of
these  companies  have  substantial  financial,  research and  development,  and
marketing  resources  and  are  capable  of  providing   significant   long-term
competition  either by  establishing  in-house  research  groups  or by  forming
collaborative ventures with other entities. In addition,  both smaller companies
and non-profit  institutions are active in research  relating to cancer and AIDS
and are expected to become more active in the future.

The Market Price for the Company's Common Stock is Volatile.

         The  market  price  of the  Company's  common  stock,  as  well  as the
securities  of  other  biopharmaceutical  and  biotechnology   companies,   have
historically  been  highly  volatile,  and  the  market  has  from  time to time
experienced  significant price and volume fluctuations that are unrelated to the
operating performance of particular  companies.  Factors such as fluctuations in
the Company's operating results,  announcements of technological  innovations or
new  therapeutic  products  by  the  Company  or its  competitors,  governmental
regulation,  developments in patent or other proprietary rights,  public concern
as to the safety of products developed by the Company or other biotechnology and
pharmaceutical  companies,  and general market conditions may have a significant
effect on the market price of the Company's Common Stock.

                       DILUTION AND COMPARATIVE SHARE DATA

         As of September  15,  1999,  the Company had  16,985,294  shares of its
common stock outstanding with a net tangible book value (total assets less total
liabilities and intangible assets) of approximately $0.40 per share.

         "Net  tangible  book value per share" is the amount that  results  from
subtracting the total  liabilities and intangible assets of the Company from its
total  assets  and  dividing  such  amount by the  shares of common  stock  then
outstanding.

         The net tangible book value of a share of the Company's common stock is
substantially  less  than the  price  which  investors  will pay for the  shares
offered by this Prospectus. The difference between the price paid by persons who
purchase the  Securities  offered by this  Prospectus  and the net tangible book
value of the Company's  common stock is the dilution  attributable to each share
of common stock.

<PAGE>

         The following table reflects the additional  shares which may be issued
as a  result  of  the  exercise  of  outstanding  options  and  warrants  or the
conversion  of other  securities  issued by the  Company.  By means of  separate
registration  statements filed with the Securities and Exchange Commission,  the
shares of common  stock  referenced  in Notes A through D are being  offered for
public sale.  The shares of common stock  issuable  upon the exercise of options
which are held by the Company's officers and directors, and which are referenced
in Note E, are being offered for sale by means of this prospectus.  See "Selling
Shareholders".

                                                   Number of             Note
                                                    Shares            Reference

Shares outstanding as of September 15,1999(1)     16,985,294

Net tangible book value per share as of
September 15, 1999 (unaudited)                         $0.40

Shares issuable upon exercise of                   1,100,000               A
Series A and Series B Warrants

Shares issuable upon exercise of                      50,000               B
Sales Agent Warrants

Shares issuable upon exercise                        285,500               C
of options granted to financial consultants

Shares issuable upon exercise of warrants
held by former holders of the
Company's Series B Preferred Stock.                   82,250               D

Shares  issuable  upon  exercise of
options and  warrants  granted to  Company's
officers, directors, employees, consultants,
and third parties                                  2,946,084               E

A.  In December  1997,  the Company sold 10,000 shares of its Series D Preferred
    Stock,  550,000  Series A Warrants  and 550,000  Series B  Warrants,  to ten
    institutional  investors for  $10,000,000.  Each Series A Warrant allows the
    holder to purchase one share of the Company's  common stock for $8.62 at any
    time prior to December 22, 2001.  Each Series B Warrant allows the holder to
    purchase one share of the Company's Common Stock for $9.31 at any time prior
    to December 22,  2001.  As of  September  15,  1999,  all Series D Preferred
    Shares had been  converted  into  5,201,462  shares of the Company's  common
    stock.

<PAGE>

B.  In connection  with the  Company's  December l997 sale of Series D Preferred
    Shares and Warrants Shoreline Pacific Institutional Finance, the Sales Agent
    for such offering,  received a commission  plus warrants to purchase  50,000
    shares of the Company's Common Stock (the "Sales Agent Warrants"). The Sales
    Agent  Warrants  are  exercisable  at a price of $8.62 per share at any time
    prior to December 22, 2001.

C.  The Company has granted  options for the purchase of an  additional  285,500
    shares  of  common  stock  to  certain  investor  relations  consultants  in
    consideration  for  services  provided  to  the  Company.  The  options  are
    exercisable at prices  ranging  between $2.50 and $7.31 per share and expire
    between September 1999 and February 2004.

D.  These  warrants  allow the holders to  purchase  up to 82,250  shares of the
    Company's common stock for $4.25 per share at any time prior to December 15,
    1999.

E.  The  options  are  exercisable  at prices  ranging  from $1.94 to $11.00 per
    share.  The Company may also grant  options to  purchase  additional  shares
    under its Incentive Stock Option and Non-Qualified Stock Option Plans.

                                 USE OF PROCEEDS

         All of the  shares  offered  by this  Prospectus  are being  offered by
certain owners of the Company's Common Stock (the Selling Shareholders) and were
issued by the Company in connection  with the Company's  employee stock bonus or
stock option plans.  None of the proceeds from this offering will be received by
the Company.  Expenses expected to be incurred by the Company in connection with
this  offering  are  estimated  to  be   approximately   $10,000.   The  Selling
Shareholders  have agreed to pay all commissions  and other  compensation to any
securities broker/dealers through whom they sell any of the Shares.

                              SELLING SHAREHOLDERS

         The  Company  has  issued (or may in the  future  issue)  shares of its
common stock to various  persons  pursuant to certain  employee  incentive plans
adopted by the Company.  The employee  incentive plans provide for the grant, to
selected employees of the Company and other persons,  of either stock bonuses or
options to purchase shares of the Company's  Common Stock.  Persons who received
Shares  pursuant to the Plans and who are offering  such Shares to the public by
means of this Prospectus are referred to as the "Selling Shareholders".

         The  Company has  adopted a number of Stock  Option  Plans as well as a
Stock Bonus Plan. A summary  description of these Plans  follows.  In some cases
these Plans are collectively referred to as the "Plans".

         Incentive  Stock Option Plans.  The Company has Incentive  Stock Option
Plans which collectively authorize the issuance of up to 1,100,000 shares of the
Company's  Common Stock to persons that exercise options granted pursuant to the
Plan. Only Company  employees may be granted  options  pursuant to the Incentive
Stock Option Plan.

<PAGE>

         Non-Qualified  Stock Option Plans. The Company has Non-Qualified  Stock
Option Plans which collectively authorize the issuance of up to 2,760,000 shares
of the Company's  Common Stock to persons that exercise options granted pursuant
to the Plans.  The Company's  employees,  directors,  officers,  consultants and
advisors  are  eligible to be granted  options  pursuant to the Plans,  provided
however that bona fide services must be rendered by such consultants or advisors
and such services must not be in connection with the offer or sale of securities
in a capital-raising transaction. The option exercise price is determined by the
Committee but cannot be less than the market price of the Company's Common Stock
on the date the option is granted.

         Stock Bonus Plans. The Company has Stock Bonus Plans which collectively
allow for the issuance of up to 340,000 shares of Common Stock.  Such shares may
consist,  in whole or in part, of authorized  but unissued  shares,  or treasury
shares.  Under  the  Stock  Bonus  Plan,  the  Company's  employees,  directors,
officers,  consultants  and  advisors  are  eligible  to  receive a grant of the
Company's  shares,  provided however that bona fide services must be rendered by
consultants  or advisors and such services  must not be in  connection  with the
offer or sale of securities in a capital-raising transaction.

         Summary. The following sets forth certain information,  as of September
15, 1999, concerning the stock options and stock bonuses granted by the Company.
Each option  represents the right to purchase one share of the Company's  Common
Stock.

                   Total Shares   Shares Reserved  Shares issued    Remaining
                     Reserved     for Outstanding    as Stock     Options/Shares
Name of Plan        Under Plan        Options          Bonus       Under Plans

Incentive Stock
 Option Plans        1,100,000        916,384            N/A          165,449
Non-Qualified
 Stock Option Plans  2,760,000      2,166,384            N/A          235,276
Stock Bonus Plans      340,000         N/A           251,811           88,189

TOTAL:

         The following  table  summarizes  the options  granted to the Company's
officers,  directors,  employees  and  consultants  pursuant  to the Plans as of
September  15,  1999.  Certain  options  were  granted  in  accordance  with the
Company's  Salary  Reduction  Plan.  Pursuant to the Salary  Reduction Plan, any
employee of the Company was allowed to receive  options  (exercisable  at market
price at time of grant) in exchange for a reduction in such employee's salary.



<PAGE>


            Name of
          Option Holder                      Shares Subject to Options (1)
          -------------                      -----------------------------

          Maximilian de Clara                            718,666
          Geert R. Kersten                             1,120,750
          Patricia B. Prichep                            229,500
          M. Douglas Winship                              94,500
          Eyal Talor, Ph.D                               130,500
          Prem Sarin, Ph.D                               149,500
          Daniel Zimmerman, Ph.D                         130,000
          Michael Lueke                                  100,000
          Employees and consultants to Company           717,667

(1) The options issued to the Company's  officers and directors are  exercisable
at prices  ranging from $1.94 to $5.60 per share.  The other  options  issued to
certain  employees of and  consultants to the Company are  exercisable at prices
ranging from $1.94 to $11.00 per share.

         Shares  issuable upon the exercise of options  granted to the Company's
officers and directors  pursuant to the Plans, as well as shares issued pursuant
to the Stock  Bonus Plan,  are being  offered by means of this  Prospectus.  The
following table provides certain information concerning the shareholdings of the
Company's  officers  and  directors  and the  shares  offered  by  means of this
Prospectus.

                                                      Number of Shares
                      Number of    Number of Shares   to be Beneficial-
  Name of              Shares       Being Offered     ly Owned on Com-   Percent
  Selling            Beneficially  Bonus     Option   pletion of the       of
Shareholder             Owned     Shares(2) Shares(2)   Offering         Class

Maximilian de Clara        --      200,000   718,666             --        --
Geert R. Kersten      108,449 (1)       -- 1,120,750        108,449         *
Patricia B. Prichep     3,030           --   229,500          3,030         *
M. Douglas Winship      2,598           --    94,500          2,598         *
Eyal Talor, Ph.D        4,290           --   130,500          4,290         *
Prem Sarin, Ph.D        2,538           --   149,500          2,538         *
Daniel Zimmerman, Ph.D 21,383          --   130,000         21,383         *
Michael Lueke              --          --   100,000             --         *

* Less than 1%.

(1) Includes  shares held in trusts for the benefit of Mr.  Kersten's  children.
(2) Represents shares issued or issuable upon exercise of stock options.

         Mr.  de Clara  and Mr.  Kersten  are  officers  and  directors  of the
Company.  The other  persons in the  foregoin  tables are  officers  of the
Company.

<PAGE>

         Each Selling Shareholder has represented that the Shares were purchased
for investment and with no present  intention of  distributing or reselling such
Shares.  However,  in  recognition  of  the  fact  that  holders  of  restricted
securities may wish to be legally  permitted to sell their Shares when they deem
appropriate,  the Company has filed with the Commission under the Securities Act
of 1933 a Form S-8 registration  statement of which this Prospectus forms a part
with   respect  to  the  resale  of  the  Shares   from  time  to  time  in  the
over-the-counter market or in privately negotiated transactions.

         Certain of the Selling  Shareholders,  their  associates and affiliates
may from time to time be employees  of,  customers  of,  engage in  transactions
with,  and/or  perform  services  for the  Company  or its  subsidiaries  in the
ordinary course of business.

                              PLAN OF DISTRIBUTION

         The Selling Shareholders may sell the Shares offered by this Prospectus
from time to time in negotiated  transactions in the over-the-counter  market at
fixed prices which may be changed from time to time, at market prices prevailing
at the time of sale, at prices  related to such  prevailing  market prices or at
negotiated  prices.  The Selling  Shareholders  may effect such  transactions by
selling the Shares to or through  broker/dealers,  and such  broker/dealers  may
receive compensation in the form of discounts,  concessions, or commissions from
the  Selling  Shareholders  and/or the  purchasers  of the Shares for which such
broker/dealers may act as agent or to whom they may sell, as principal,  or both
(which  compensation  as to a  particular  broker/dealer  may  be in  excess  of
customary compensation).

         The Selling  Shareholders and any  broker/dealers who act in connection
with the sale of the Shares hereunder may be deemed to be "underwriters"  within
the meaning of  ss.2(11) of the  Securities  Acts of 1933,  and any  commissions
received  by them and profit on any resale of the Shares as  principal  might be
deemed to be underwriting  discounts and  commissions  under the Securities Act.
The Company has agreed to indemnify the Selling  Shareholders and any securities
broker/dealers who may be deemed to be underwriters against certain liabilities,
including liabilities under the Securities Act as underwriters or otherwise.

         The Company has  advised  the  Selling  Shareholders  that they and any
securities   broker/dealers  or  others  who  may  be  deemed  to  be  statutory
underwriters will be subject to the Prospectus  delivery  requirements under the
Securities  Act of 1933.  The Company has also advised each Selling  Shareholder
that in the  event  of a  "distribution"  of the  shares  owned  by the  Selling
Shareholder,  such Selling  Shareholder,  any "affiliated  purchasers",  and any
broker/  dealer or other person who  participates  in such  distribution  may be
subject to Rule 102 under the Securities Exchange Act of 1934 ("1934 Act") until
their  participation  in that  distribution is completed.  A  "distribution"  is
defined in Rule 102 as an offering of  securities  "that is  distinguished  from
ordinary trading  transactions by the magnitude of the offering and the presence
of special  selling efforts and selling  methods".  The Company has also advised
the  Selling  Shareholders  that  Rule 101  under  the 1934  Act  prohibits  any
"stabilizing bid" or "stabilizing  purchase" for the purpose of pegging,  fixing
or stabilizing the price of the Common Stock in connection with this offering.



<PAGE>


                           DESCRIPTION OF COMMON STOCK

         The shares of Common Stock  offered by this  Prospectus  are fully paid
and  non-assessable.  Holders of the Common Stock do not have preemptive rights.
Each  stockholder is entitled to one vote for each share of Common stock held of
record by such stockholder.  There is no right to cumulate votes for election of
directors.  Upon liquidation of the Company,  the assets then legally  available
for  distribution  to holders of the Common  Stock will be  distributed  ratably
among such shareholders in proportion to their stock holdings. Holders of Common
Stock  are  entitled  to  dividends  when,  as and if  declared  by the Board of
Directors out of funds legally available therefor.

                                     GENERAL

         The  Company's  Bylaws  provide  that the Company  will  indemnify  its
directors and officers  against  expense and  liabilities  they incur to defend,
settle or satisfy any civil or criminal  action brought against them as a result
of their being or having been Company  directors or officers unless, in any such
action,  they have acted with gross negligence or willful  misconduct.  Officers
and Directors are not entitled to be indemnified for claims or losses  resulting
from a breach of their duty of loyalty to the Company, for acts or omissions not
in good faith or which involve intentional  misconduct or a knowing violation of
law or a  transaction  from  which the  director  derived an  improper  personal
benefit. Insofar as indemnification for liabilities arising under the Securities
Act of l933 may be  permitted  to the  Company's  directors  and  officers,  the
Company has been  informed  that in the opinion of the  Securities  and Exchange
Commission  such  indemnification  is against  public policy as expressed in the
Securities Act of l933, and is, therefore, unenforceable.

         No dealer,  salesman,  or any other person has been  authorized to give
any  information or to make any  representations  other than those  contained in
this  prospectus  in connection  with this offering and, if given or made,  such
information or representations must not be relied upon as having been authorized
by the Company or the selling shareholders.  This prospectus does not constitute
an offer to sell, or a solicitation of any offer to buy, the securities  offered
in any  jurisdiction  to any person to whom it is  unlawful  to make an offer or
solicitation.  Neither  the  delivery  of  this  prospectus  nor any  sale  made
hereunder shall, under any  circumstances,  create an implication that there has
not been any change in the affairs of the Company  since the date hereof or that
any  information  contained  herein is correct as to any time  subsequent to its
date.

         All  dealers  effecting  transactions  in  the  registered  securities,
whether or not participating in this distribution,  may be required to deliver a
prospectus.  This is an  addition  to the  obligation  of  dealers  to deliver a
prospectus  when  acting  as  underwriters  and with  respect  to  their  unsold
allotments or subscriptions.




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