SCIOS NOVA INC
DEF 14A, 1996-03-27
PHARMACEUTICAL PREPARATIONS
Previous: CONSOLIDATED CAPITAL PROPERTIES V, 10KSB, 1996-03-27
Next: UNITED SECURITY BANCORPORATION, 10KSB, 1996-03-27



<PAGE>
                            SCHEDULE 14A INFORMATION
 
                  Proxy Statement Pursuant to Section 14(a) of
            the Securities Exchange Act of 1934 (Amendment No.    )
 
    Filed by the Registrant / /
    Filed by a Party other than the Registrant / /
 
    Check the appropriate box:
    / /  Preliminary Proxy Statement
    / /  Confidential, for Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
    /X/  Definitive Proxy Statement
    / /  Definitive Additional Materials
    / /  Soliciting  Material  Pursuant  to  Section  240.14a-11(c)  or  Section
         240.14a-12
 
                          SCIOS INC. (FORMERLY SCIOS NOVA INC.)
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
 
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
/X/  $125 per  Exchange Act  Rules 0-11(c)(1)(ii),  14a-6(i)(1), 14a-6(i)(2)  or
     Item 22(a)(2) of Schedule 14A.
/ /  $500  per  each party  to  the controversy  pursuant  to Exchange  Act Rule
     14a-6(i)(3).
/ /  Fee  computed  on   table  below   per  Exchange   Act  Rules   14a-6(i)(4)
     and 0-11.
     1) Title of each class of securities to which transaction applies:
        ------------------------------------------------------------------------
     2) Aggregate number of securities to which transaction applies:
        ------------------------------------------------------------------------
     3) Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
        filing fee is calculated and state how it was determined):
        ------------------------------------------------------------------------
     4) Proposed maximum aggregate value of transaction:
        ------------------------------------------------------------------------
     5) Total fee paid:
        ------------------------------------------------------------------------
/ /  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2)  and identify the  filing for which the  offsetting fee was paid
     previously. Identify the previous filing by registration statement  number,
     or the Form or Schedule and the date of its filing.
     1) Amount Previously Paid:
        ------------------------------------------------------------------------
     2) Form, Schedule or Registration Statement No.:
        ------------------------------------------------------------------------
     3) Filing Party:
        ------------------------------------------------------------------------
     4) Date Filed:
        ------------------------------------------------------------------------
<PAGE>
                                     [LOGO]
                                   SCIOS INC.
                             2450 BAYSHORE PARKWAY
                        MOUNTAIN VIEW, CALIFORNIA 94043
 
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             TUESDAY, MAY 14, 1996
                                   10:00 A.M.
 
To the Stockholders:
 
    NOTICE  IS HEREBY  GIVEN that  the Annual  Meeting of  Stockholders of Scios
Inc., a Delaware  corporation (the  "Company"), will  be held  at the  Company's
principal  executive offices,  2450 Bayshore Parkway,  Mountain View, California
94043, at 10:00  a.m. on Tuesday,  May 14, 1996,  to consider and  act upon  the
following matters:
 
    (1) To elect directors of the Company.
 
    (2)  To  ratify and  approve an  amendment to  the Company's  Certificate of
       Incorporation to change the Company's name to Scios Inc.
 
    (3) To ratify  the selection of  Coopers & Lybrand  L.L.P. as the  Company's
       independent auditors for fiscal 1996.
 
    (4)  To consider the  stockholder proposal set forth  in the following Proxy
       Statement.
 
    (5) To transact such other business as may properly come before the  meeting
       or any adjournment or postponement of the meeting.
 
    Only  stockholders of record at the close of business on March 18, 1996 will
be entitled to  notice of and  to vote at  this meeting and  any adjournment  or
postponement thereof.
 
                                          By Order of the Board of Directors
                                          JOHN H. NEWMAN
                                          SECRETARY
 
Mountain View, California
March 26, 1996
 
YOUR VOTE IS IMPORTANT. WHETHER OR NOT YOU EXPECT TO ATTEND THIS MEETING, PLEASE
MARK,  DATE AND  SIGN THE ENCLOSED  PROXY AND  MAIL IT PROMPTLY  IN THE ENCLOSED
ENVELOPE. NO POSTAGE IS REQUIRED IF MAILED IN THE UNITED STATES.
<PAGE>
                                   SCIOS INC.
                             2450 BAYSHORE PARKWAY
                        MOUNTAIN VIEW, CALIFORNIA 94043
 
                                PROXY STATEMENT
                         ANNUAL MEETING OF STOCKHOLDERS
                                  MAY 14, 1996
 
GENERAL
 
    This  Proxy Statement is  solicited on behalf  of the Board  of Directors of
Scios Inc., a Delaware  corporation (the "Company" or  "Scios"), for use at  its
Annual  Meeting of Stockholders to be  held at the Company's principal executive
offices, 2450 Bayshore Parkway, Mountain  View, California 94043, at 10:00  a.m.
on  Tuesday,  May 14,  1996,  and at  any  adjournment or  postponement  of that
meeting. The approximate mailing date for this Proxy Statement and the  enclosed
proxy is March 26, 1996.
 
    The  Board of Directors has fixed the close of business on March 18, 1996 as
the record date for  the determination of stockholders  entitled to vote at  the
Annual  Meeting.  At that  time, there  were 36,102,949  shares of  Common Stock
issued and  outstanding. In  addition,  there were  16,053 shares  of  Nonvoting
Series A Preferred Stock issued and outstanding.
 
VOTING
 
    Each  share of  Common Stock  issued and outstanding  on the  record date is
entitled to one vote. The Nonvoting Series A Preferred Stock is not entitled  to
vote.   The  proxy  holders  will  vote  all  proxies  in  accordance  with  the
instructions contained in the  proxy and, if no  choice is specified, the  proxy
holders  will vote in favor  of the proposals to  elect directors, to ratify and
approve the name change and to ratify the selection of auditors and against  the
stockholder proposal. An automated system administered by the Company's transfer
agent  tabulates the votes. The  presence at the Annual  Meeting in person or by
proxy of  a majority  of  the shares  outstanding as  of  the record  date  will
constitute  a quorum. For quorum purposes,  abstentions and broker non-votes are
each included in the determination of  the number of shares present and  voting.
Each  matter is tabulated separately. Abstentions  are counted in tabulations of
the votes cast on proposals presented to stockholders, whereas broker  non-votes
are  not counted  for any  purpose in  determining whether  a proposal  has been
approved.
 
REVOCABILITY OF PROXIES
 
    Any person giving a proxy in the form accompanying this Proxy Statement  has
the  power to revoke  it at any time  before its exercise. It  may be revoked by
filing with the Secretary of the Company  an instrument of revocation or a  duly
executed proxy bearing a later date. It also may be revoked by attendance at the
meeting  and election  to vote  in person.  Attendance at  the meeting  will not
itself revoke a proxy.
 
SOLICITATION
 
    The Company will bear the entire cost of preparing, assembling, printing and
mailing this Proxy Statement, the accompanying proxy and any additional material
which may be furnished  to stockholders by the  Company. Copies of  solicitation
material  will be furnished without charge  to brokerage houses, fiduciaries and
custodians to forward  to beneficial owners  of stock held  in their names.  The
solicitation  of proxies will be made by the use of the mails and through direct
communication with certain  stockholders or their  representatives by  officers,
directors  and  employees  of  the  Company,  who  will  receive  no  additional
compensation therefor. In  addition, the  Company may determine  to engage  D.F.
King  & Co., Inc.  ("D.F. King") or  another proxy solicitor  to solicit proxies
and, if it does so,  the Company will pay the  standard fee for these  services,
which is estimated to be approximately $6,000.
<PAGE>
                           (1) ELECTION OF DIRECTORS
 
    A  Board of seven (7)  Directors will be elected  at the Annual Meeting. The
term of office of each person elected as a Director will continue until the next
Annual Meeting  and  until  a  successor  has  been  elected.  Unless  otherwise
instructed,  the proxy holders  will vote the  proxies received by  them for the
seven nominees of the Board of Directors named below, all of whom are  presently
Directors  of the Company. The candidates receiving  a plurality of the votes of
the shares present in  person or by  proxy at the meeting  and entitled to  vote
will  be elected.  Each person  nominated for  election has  agreed to  serve if
elected and management has no reason to believe that any nominee will be  unable
to  serve. If  any nominee for  any reason is  unable or declines  to serve, the
proxies will be voted for any substitute nominee who shall be designated by  the
present  Board  of Directors  to fill  the vacancy.  Stockholders who  desire to
nominate persons for election to the  Board must comply with the advance  notice
procedures specified in the Company's Bylaws.
 
    William  F. Miller, Ph.D. served as a Director of the Company since February
1993 and concurrently served on the Audit Committee. Donald E. O'Neill served as
a Director of the  Company since September 1992  and concurrently served on  the
Compensation Committee. Dr. Miller and Mr. O'Neill have indicated that they will
not  stand for  re-election as  Directors of  Scios at  the 1996  Annual Meeting
because of increased demands on their  time. The Board of Directors extends  its
sincere  appreciation to Dr.  Miller and Mr. O'Neill  for their contributions to
and efforts on behalf of Scios.
 
    The following is information  regarding the nominees, including  information
furnished  by them as to their  principal occupation for the preceding five-year
period, certain directorships and their ages as of March 18, 1996.
 
<TABLE>
<CAPTION>
                                                                                        DIRECTOR
                                  NAME                                        AGE         SINCE
- ------------------------------------------------------------------------      ---      -----------
<S>                                                                       <C>          <C>
Samuel H. Armacost                                                                56         1995
Richard L. Casey                                                                  49         1987
Myron Du Bain                                                                     72         1989
Robert W. Schrier, M.D.                                                           60         1988
Solomon H. Snyder, M.D.                                                           57         1992
Burton E. Sobel, M.D.                                                             58         1996
Eugene L. Step                                                                    67         1993
</TABLE>
 
    Mr. Armacost was elected to the Company's Board of Directors in August 1995.
Since September 1990, Mr. Armacost has been a Principal of Weiss, Peck &  Greer,
L.L.C.,  an investment firm. He was a Managing Director of Merrill Lynch Capital
Markets from  1987  to  August  1990, and  was  President,  Director  and  Chief
Executive  Officer of BankAmerica Corporation from 1981 to 1986. Mr. Armacost is
also a member  of the  Board of Directors  of Chevron  Corporation, The  Failure
Group,  Inc. and SRI International. In addition, Mr. Armacost is on the board of
the James Irvine Foundation and the Advisory Board of the California Academy  of
Sciences, and he is a member of The Business Council.
 
    Mr. Casey is Chairman of the Board, President and Chief Executive Officer of
Scios  Inc. He joined  Scios in December  1987 as President  and Chief Executive
Officer, and has served  as a Director  since that time.  Mr. Casey was  elected
Chairman  of the Board  in November 1992. From  early 1985 to  1987, he was with
ALZA  Corporation   as  Executive   Vice  President   and  President   of   ALZA
Pharmaceuticals.  From 1976 to 1985 he  worked for Syntex Corporation. He joined
Syntex Laboratories  in 1976  as  a manager  and  became director  of  marketing
research in the following year. In 1979, he was named director of sales, in 1981
was  promoted to  vice president  and in 1983  was appointed  general manager of
Syntex Medical Diagnostics. Mr. Casey began  his career in pharmaceuticals as  a
sales  representative for Eli  Lilly and Company.  From 1968 to  1970, Mr. Casey
served in the U.S. Peace Corps in Ethiopia.
 
                                       2
<PAGE>
Mr. Casey serves on the boards  of Guilford Pharmaceuticals Inc., an  affiliated
publicly-held  development-stage  neuroscience  company  located  in  Baltimore,
Maryland; VIVUS, Inc., a publicly-held medical devices company located in  Menlo
Park, California; and Karo Bio AB, an affiliated Swedish biotechnology company.
 
    Mr. Du Bain was elected a Director of Scios in June 1989. He was Chairman of
the  Board  of  Directors of  SRI  International  of Menlo  Park,  California, a
contract research and consulting company, from December 1985 until he retired in
December 1989. From 1983 to 1985,  he was President and Chief Executive  Officer
of  Amfac, Inc.,  a diversified  industry company.  Previously, Mr.  Du Bain was
Chairman, President and  Chief Executive Officer  of Fireman's Fund  Corporation
and  Vice Chairman of American  Express Company. He is a  member of the board of
directors of  SRI  International,  First  Interstate  Bancorp  and  Transamerica
Corporation.  In addition,  Mr. Du Bain  is Chairman  of the Board  of the James
Irvine Foundation.
 
    Dr. Schrier was  elected a Director  of Scios  in August 1988.  He has  been
Professor and Chairman, Department of Medicine, University of Colorado School of
Medicine,  since 1976. Dr. Schrier is Chairman  of the Board and Chief Executive
Officer of Multum Information Services,  Inc., a privately-held company  located
in  Denver, Colorado. He has held  numerous positions in professional societies,
including President  of  the  National  Kidney Foundation  from  1984  to  1986,
President  of  the American  Society  of Nephrology  in  1984, President  of the
Association of American Physicians  in 1995, and is  presently President of  the
International  Society of  Nephrology. He  received the  Pasteur Award  from the
University of Strasbourg; the John Phillips  Award from the American College  of
Physicians;  the David Hume Award from  the National Kidney Foundation; honorary
Doctorate of Sciences from DePauw University; and the Mayo Soley Award from  the
Western  Society of Clinical Investigation. He  has also served on the editorial
boards of numerous professional publications,  has authored over 600  scientific
articles  and has  edited numerous  medical texts and  reference books.  He is a
member of the Institute of Medicine of the National Academy of Sciences.
 
    Dr. Snyder was elected a Director  in September 1992 in connection with  the
merger  with  Nova Pharmaceutical  Corporation. Dr.  Snyder  is Director  of the
Department of Neuroscience and Distinguished Service Professor of  Neuroscience,
Pharmacology  and  Molecular  Sciences  and  Psychiatry  at  The  Johns  Hopkins
University, and has been a member of the faculty there since 1966. Prior to  the
merger,  Dr. Snyder was a member of  Nova's board and Chairman of its Scientific
Advisory Board. Dr. Snyder received the Albert Lasker Award for Basic Biomedical
Research and Honorary  Doctor of Science  degrees from Northwestern  University,
Georgetown  University and Ben Gurion University.  Dr. Snyder received the Wolfe
Award in  Medicine  from the  government  of  Israel for  research  relating  to
receptors.  Dr. Snyder  is a member  of the  National Academy of  Sciences and a
Fellow of the  American Academy of  Arts and  Sciences. Dr. Snyder  is also  the
author  of numerous articles  and several books.  Dr. Snyder is  a founder and a
director of Guilford Pharmaceuticals Inc.
 
    Dr. Sobel  was elected  a Director  in  February 1996.  Dr. Sobel  has  been
Physician-in-Chief,  E.L.  Amidon  Professor  and  Chair  of  the  Department of
Medicine  at  The  University  of  Vermont  College  of  Medicine  since   1994.
Previously,  Dr. Sobel was Professor of  Medicine at Barnes Hospital, Washington
University and Director  of its Cardiovascular  Division. Dr. Sobel  has been  a
consultant   to   and  served   on  scientific   advisory  boards   of  numerous
pharmaceutical and biotechnology companies. Dr. Sobel has been the recipient  of
numerous  awards, including  the American  Heart Association's  James B. Herrick
Award and its Scientific Council's  Distinguished Achievement Award, as well  as
the  American College of  Cardiology's Distinguished Scientist  award. Dr. Sobel
has been the  editor of CIRCULATION  and, since  1989, has served  as editor  of
CORONARY  ARTERY DISEASE. His  memberships and fellowships  include the American
College of Physicians, Royal Society of Medicine, American Heart Association and
American College of Cardiology.
 
    Mr. Step was elected  a Director in  February 1993. From  May 1956 until  he
retired  in December 1992, Mr. Step was  employed by Eli Lilly and Company, most
recently as Executive Vice President,
 
                                       3
<PAGE>
President of  the Pharmaceutical  Division, where  he was  responsible for  U.S.
pharmaceutical  operations and for the operations of Eli Lilly International. In
addition, from September 1973 through 1992, Mr. Step served on Eli Lilly's board
of directors and executive committee. Mr. Step  is a past chairman of the  board
of  directors of the Pharmaceutical Manufacturers Association and immediate past
president  of  the  International  Federation  of  Pharmaceutical  Manufacturers
Associations.  He is a  member of the  board of directors  of Cell Genesys Inc.,
GMIS  Inc.,   Guidant  Corporation,   Medco  Research   Inc.  and   Pathogenesis
Corporation.
 
                  INFORMATION ABOUT THE BOARD OF DIRECTORS AND
                            COMMITTEES OF THE BOARD
 
    The  information reflected herein  includes Steven D.  Goldby, President and
Chief Executive  Officer of  MDL  Information Systems,  Inc.,  who served  as  a
Director  of the Company from  December 1989 through May  8, 1995, at which time
Mr. Goldby did not  stand for re-election due  to increasing outside demands  on
his time and resources.
 
    COMPENSATION OF DIRECTORS -- STANDARD ARRANGEMENTS
 
    FEES.   Directors who are  not otherwise employed by  the Company receive an
annual retainer of  $12,000 and an  additional fee of  $1,000 for attendance  at
each  meeting  of  the Board  of  Directors,  and $500  for  attendance  at each
committee meeting  not occurring  within 24  hours of  a Board  meeting. In  the
fiscal year ended December 31, 1995, the aggregate compensation paid to eligible
non-employee Directors (8 individuals) under standard arrangements was $103,000.
The  members of the  Board of Directors  are also eligible  for reimbursement of
expenses incurred in connection with attendance at Board meetings in  accordance
with  Company  policy. In  the event  that a  Director is  also in  a consulting
relationship with  the Company,  such Director  does not  receive Directors'  or
meeting fees.
 
    STOCK  OPTIONS.   At the  time of election  to the  Board, each non-employee
Director is automatically granted an option to purchase 20,000 shares of  Common
Stock.  These  options are  currently granted  under  the Company's  1992 Equity
Incentive Plan (the "Incentive Plan"),  which contains provisions for  automatic
grants  to non-employee  Directors. Prior  to its  expiration on  June 30, 1994,
option grants to Directors were also made under the Company's 1989  Non-Employee
Director Stock Option Plan (the "1989 Director Plan"). These plans were approved
by  the  Company's stockholders  in May  1992 and  May 1990,  respectively. Only
non-employee Directors of the Company are eligible to receive options under  the
applicable  provisions  of  the  Incentive  Plan  and  the  1989  Director  Plan
(collectively, the "Director Plans"). Mr. Armacost, Mr. Du Bain, Mr. Goldby, Dr.
Miller, Dr. Schrier, Dr.  Sobel and Mr. Step  each received option grants  under
the  Director Plans. Mr.  O'Neill and Dr. Snyder  voluntarily declined to accept
the grants to  which they were  entitled upon  their elections to  the Board  in
September  1992 in connection with the merger of Nova Pharmaceutical Corporation
("Nova") into  the Company  (the "Merger").  Mr. Casey,  as an  employee of  the
Company, is not eligible for grants under the Director Plans. On the date that a
non-employee  Director becomes fully vested in his option, he will automatically
be granted an  additional option  under the  Incentive Plan  to purchase  10,000
shares  of the Company's Common Stock at a per share exercise price equal to the
fair market value of the stock on the date of grant.
 
    Options granted to non-employee Directors do not qualify as incentive  stock
options  under the Internal Revenue  Code of 1986, as  amended (the "Code"). The
exercise price of options granted to non-employee Directors is 100% of the  fair
market  value of the  Common Stock subject to  the option on  the date of grant.
Such options  vest over  five years  of service  and have  terms of  ten  years;
however, in the event of termination of service on the Board, the vested portion
of the option will expire on the earlier of the expiration date or twelve months
from  the  date  of termination,  unless  the  termination is  due  to  death or
disability, in  which  case  the  option  will expire  on  the  earlier  of  the
expiration  date  or eighteen  months from  the  termination date.  With limited
exceptions, the recipient of an option under
 
                                       4
<PAGE>
the Director Plans will  forfeit all unvested portions  of an option under  such
plans  upon termination of his service as a non-employee Director. Unless sooner
terminated, the Incentive Plan will terminate on February 10, 2002.
 
    COMPENSATION OF DIRECTORS -- OTHER ARRANGEMENTS.
 
    In 1993, the  Company formed  a new company,  Guilford Pharmaceuticals  Inc.
("Guilford"),   to  pursue  the  development   of  pharmaceutical  products  for
neurological and  neurosurgical applications.  In 1994,  Guilford completed  its
initial  public offering of common  stock. Mr. Casey is  a director of Guilford,
and Dr. Snyder is a founder and a director of Guilford. Through August 31, 1995,
Dr. Snyder received consulting  fees from the Company  pursuant to a  consulting
agreement  that the Company assumed in connection with the Merger. In connection
with the formation of Guilford, Dr. Snyder and the Company amended the agreement
in August 1993  to allow Dr.  Snyder to divide  his consulting services  between
Guilford  and  the Company  and reduced  the consulting  fees payable  under the
agreement. In 1995, the Company paid Dr. Snyder $66,666 in consulting fees.  The
agreement  terminated on August  31, 1995. As  of September 1,  1995, Dr. Snyder
began receiving standard Director and meeting fees as described above.
 
    BOARD OF DIRECTORS.   During fiscal 1995, there  were seven meetings of  the
Board of Directors.
 
    AUDIT   COMMITTEE.    The  Company's   Audit  Committee  consists  of  three
non-employee Directors: Mr.  Step (Chairman),  Mr. Miller and  Mr. O'Neill.  The
Audit  Committee met two  times in fiscal 1995.  Among the committee's functions
are recommending  engagement of  the Company's  independent auditors,  approving
services  performed by such auditors, and reviewing and evaluating the Company's
accounting systems and its system of internal accounting controls.
 
    COMPENSATION COMMITTEE.  From  January 1, 1995 through  March 30, 1995,  the
Company's  Compensation Committee consisted of three non-employee Directors: Mr.
Goldby (Chairman),  Mr. Du  Bain and  Mr. O'Neill.  As of  March 31,  1995,  the
members  of  the committee  were Mr.  O'Neill  (Chairman) and  Mr. Du  Bain. Mr.
Armacost was  appointed to  the committee  upon his  election as  a Director  in
August  1995.  The  committee  met  five times  during  fiscal  1995.  Among the
committee's functions are establishing  the Company's compensation programs  for
all  employees,  fixing the  compensation levels  of  executive officers  of the
Company, and  administering  and making  awards  under the  Company's  incentive
programs.
 
    NOMINATING  COMMITTEE.   As of December  31, 1995,  the Nominating Committee
consisted of three non-employee Directors:  Myron Du Bain (Chairman), Robert  W.
Schrier  and Eugene L. Step. As of March  31, 1995, Mr. Step replaced Mr. Goldby
on the  committee.  The  committee  met  one time  in  fiscal  1995.  Among  the
committee's  functions  are  recommending  nominees to  serve  on  the  Board of
Directors, recommending  size and  composition  of the  Board based  on  studies
conducted  by  the  committee,  making recommendations  to  the  Board regarding
stockholders' comments as  to composition of  the Board, making  recommendations
concerning  membership of  Board committees  and Board  and committee  fees, and
consulting with the Board of Directors and management to determine criteria  for
nominations.  The  Nominating Committee  will  consider nominees  recommended by
stockholders.  Any   such   recommendations,   together   with   the   nominee's
qualifications  and consent to being considered as  a nominee, should be sent to
the Secretary of  the Company no  later than November  26, 1996 in  order to  be
considered for election at the 1997 Annual Meeting of Stockholders.
 
    In  fiscal 1995, all Directors attended at  least 75% of the meetings of the
Board and all committees of the Board of which they were members.
 
                                       5
<PAGE>
          SECURITY OWNERSHIP OF MANAGEMENT AND PRINCIPAL STOCKHOLDERS
                              BENEFICIAL OWNERSHIP
 
    The following table sets forth certain information regarding the  beneficial
ownership  of the Company's  Common Stock at  March 18, 1996  by (i) all persons
known by the  Company to  be beneficial  owners of more  than 5%  of its  Common
Stock,  (ii) each Director,  (iii) each of  the executive officers  named in the
Summary Compensation Table included herein and (iv) all Directors and  executive
officers of the Company as a group.
 
<TABLE>
<CAPTION>
                                                                BENEFICIAL OWNERSHIP(1)
                                                              ----------------------------
                                                              BENEFICIALLY   APPROXIMATE
                   OFFICERS, DIRECTORS &                         OWNED       PERCENT OF
                      5% STOCKHOLDERS                          SHARES(2)        CLASS
- ------------------------------------------------------------  -----------  ---------------
<S>                                                           <C>          <C>
State of Wisconsin Investment Board                             2,009,100(3)         5.6%
P. O. Box 78432
Madison, WI 53707
 
Samuel H. Armacost                                                 10,000         *
Richard L. Casey                                                  474,760(4)         1.3%
Myron Du Bain                                                      28,500         *
William F. Miller, Ph.D.                                           15,000(4)        *
Donald E. O'Neill                                                 115,860         *
Robert W. Schrier, M.D.                                            13,800         *
Solomon H. Snyder, M.D.                                            10,000         *
Burton E. Sobel, M.D.                                             --             --
Eugene L. Step                                                     14,000         *
 
Elliott B. Grossbard, M.D.                                        139,616         *
John A. Lewicki, Ph.D.                                            162,567         *
Arlene M. Morris                                                   45,438         *
Armin H. Ramel, Ph.D.                                              48,809         *
 
All officers and directors as a group (15 persons)              1,275,884(4)         3.4%
</TABLE>
 
- ------------------------
*   less than 1%
 
(1) Unless  otherwise indicated  below and  subject to  community property laws,
    each stockholder has sole  voting and investment power  with respect to  the
    shares beneficially owned.
 
(2) For  Mr. Casey, Mr. Du Bain, Dr. Miller, Mr. O'Neill, Dr. Schrier, Mr. Step,
    Dr. Grossbard, Dr. Lewicki, Mrs. Morris and Dr. Ramel, and all officers  and
    directors  as  a group,  includes 440,000;  18,500; 9,000;  106,860; 13,500;
    13,000;  137,332;   146,666;   45,438;   47,221;   and   1,115,766   shares,
    respectively,  issuable  upon  exercise of  outstanding  options exercisable
    within sixty days of March 18, 1996.
 
(3) Information is as of December 31, 1995 as provided by the holder on Schedule
    13D filed with the Securities and Exchange Commission.
 
(4) With respect to Mr.  Casey, includes 8,737  shares held in  a trust for  the
    benefit  of  Mr. Casey's  children,  of which  Mr.  Casey and  his  wife are
    trustees. With respect  to Dr.  Miller, includes 6,000  shares held  jointly
    with his wife in a trust, of which Dr. Miller and his wife are trustees.
 
    The Company is not aware of any material proceeding to which any Director or
executive  officer  of the  Company or  any  associate of  any such  Director or
executive officer is a party adverse to  the Company or any of its  subsidiaries
or has a material interest adverse to the Company or any of its subsidiaries.
 
                                       6
<PAGE>
COMPLIANCE WITH SECTION 16(A) OF THE EXCHANGE ACT
 
    Section  16(a)  of the  Securities  Exchange Act  of  1934, as  amended (the
"Exchange Act"),  requires  the  Company's  Directors,  executive  officers  and
holders  of more  than ten  percent (10%)  of the  Company's Common  Stock ("10%
Holders") to  file  with the  Securities  and Exchange  Commission  (the  "SEC")
initial reports of ownership and reports of changes in ownership of Common Stock
and  other equity securities  of the Company.  Directors, executive officers and
10% Holders are required by SEC regulation to furnish the Company with copies of
all Section 16(a) forms they file.
 
    The Company believes that  during the fiscal year  ended December 31,  1995,
its  Directors, executive  officers and  10% Holders  complied with  all Section
16(a) filing requirements. In making this statement, the Company has relied upon
the written representations  of its  Directors, executive  officers and  certain
other reporting persons.
 
                             EXECUTIVE COMPENSATION
 
    The  following table discloses compensation  received by the Company's Chief
Executive Officer and each of its  four other most highly compensated  executive
officers at December 31, 1995 for the fiscal years ended December 31, 1995, 1994
and 1993.
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                                              LONG-TERM
                                                                                             COMPENSATION
                                                                                                AWARDS
                                                                                             ------------
                                                                ANNUAL COMPENSATION           SECURITIES
                                                         ---------------------------------    UNDERLYING       ALL OTHER
                                                                      SALARY    BONUS(1)        STOCK       COMPENSATION(2)
NAME AND PRINCIPAL POSITION                               YEAR         ($)         ($)       OPTIONS (#)          ($)
- -------------------------------------------------------  -------     --------  -----------   ------------   ---------------
<S>                                                      <C>         <C>       <C>           <C>            <C>
RICHARD L. CASEY                                            1995     $400,000      --          120,000          $3,000
 Chairman of the                                            1994     $400,000  $   104,000      --              $3,000
 Board, President                                           1993     $400,000  $    48,000      --              $3,000
 and Chief Executive Officer
 
ELLIOTT B. GROSSBARD, M.D.                                  1995     $208,000  $    60,577(3)    39,000         $3,000
 Vice President of                                          1994     $208,000  $    80,000(3)    --             $3,000
 Medical and                                                1993     $200,000  $    24,000      --              $3,000
 Regulatory Affairs
 
JOHN A. LEWICKI, PH.D.                                      1995     $208,000  $    24,904      39,000          $3,000
 Vice President                                             1994     $208,000  $    40,000      --              $3,000
 of Research                                                1993     $200,000  $    24,000      10,000(4)       $3,000
 
ARLENE M. MORRIS                                            1995     $175,000  $    58,166(3)    40,100         $3,000
 Vice President of                                          1994     $175,000  $   108,200(3)    --             $3,000
 Business                                                   1993(5)  $123,032  $    36,964(3)    70,000         $3,000
 Development
 
ARMIN H. RAMEL, PH.D.                                       1995     $195,700  $    20,084      37,000          $3,000
 Vice President of                                          1994     $195,700  $    35,000      --              $3,000
 Development                                                1993(6)  $145,000  $    11,400      75,000          $3,000
</TABLE>
 
- ------------------------
(1) Except  as is  further described  in footnote 3  below (with  respect to Dr.
    Grossbard and  Mrs. Morris),  bonus amounts  represent the  value of  awards
    under  the Company's Senior Staff Incentive Plan (the "SSI Plan"). The Board
    of Directors adopted the SSI Plan in 1989 and reserved 300,000 shares of the
    Company's Common Stock for issuance to eligible key employees. The Company's
    stockholders approved the SSI Plan in May 1990. Awards to executive officers
    under the SSI Plan are determined annually by the Compensation Committee. As
    of March  18,  1996,  approximately  5,000  shares  remained  available  for
    issuance  under the  SSI Plan. Unless  sooner terminated, the  SSI Plan will
    terminate on March 31, 1996.
 
                                       7
<PAGE>
(2) Consists of Company matching contributions  under the 401(k) Profit  Sharing
    Plan  and Trust, which was established in 1986. As of December 31, 1995, the
    Company made matching contributions of 100% of participant contributions, up
    to a maximum of $3,000 per participant per plan year. Employee contributions
    are at all  times 100%  vested. The  Company's contributions  vest based  on
    years  of service: 0% for less than one  year; 25% for one but less than two
    years; 50% for two  but less than  three years; and 100%  for three or  more
    years.  Federal tax laws impose  an overall limit on  the amount that may be
    contributed by participants each year under 401(k) plans. For calendar  year
    1995,  participant contributions were limited to the lesser of $9,240 or 15%
    of such participant's salary for the year.
 
(3) Dr. Grossbard's bonuses for 1995 and 1994 include forgiveness of $25,000  in
    each  year under a loan made to him  at the time he joined the Company. Mrs.
    Morris' bonus amounts for 1995, 1994 and 1993 include mortgage  differential
    payments  of  $43,200, $43,200  and  $22,200, respectively;  see  footnote 5
    below.
 
(4) In August 1993, the Compensation Committee extended the exercise periods for
    an aggregate of 151,511 stock options  held by 100 employees (the  "Affected
    Options").  Prior to this action, these options had exercise periods of less
    than 10 years from their original grant dates. The extensions were  approved
    to  equalize  the treatment  of all  employees following  the merger  of the
    Company and  Nova because  of the  significant number  of employees  holding
    options  with terms of less  than 10 years. Other  than the extension of the
    exercise periods of the Affected Options, no other features were changed. In
    particular, such  options  retained  their original  vesting  schedules  and
    exercise  prices,  which exceeded  the  fair market  value  on the  date the
    options were extended.  The extension  of the  Affected Option  held by  Dr.
    Lewicki  is required to be  reported in this table as  a new grant, but such
    extension did not increase the aggregate number of options held by him.
 
(5) Mrs. Morris joined  the Company  in April  1993. The  amounts indicated  for
    salary  and bonus in  1993 were pro  rated based on  an annualized salary of
    $170,000. The Company agreed to  reimburse Mrs. Morris the costs  associated
    with  her relocation  from Pennsylvania  to California  when she  joined the
    Company, which costs aggregated $49,200, of which $29,500 related to  moving
    costs and $19,700 related to interim housing and closing costs. In addition,
    the  Company agreed to  make mortgage differential  payments to Mrs. Morris,
    which  payments  take  into   account  the  mortgage  differential   between
    Pennsylvania and California. Unless Mrs. Morris' employment with the Company
    terminates,  she  will receive  mortgage  differential payments  as follows:
    $3,600 per month through April 30, 1996; $3,200 per month through April  30,
    1999; and $2,800 per month through April 30, 2002.
 
(6) Dr.  Ramel joined the Company in  July 1993. The amounts indicated represent
    compensation for that  year based on  an annualized salary  of $190,000  and
    include a $50,000 signing bonus.
 
                       STOCK OPTION GRANTS AND EXERCISES
 
    In  the  Company's  efforts  to  recruit  the  best  available  talent  in a
competitive labor market,  the Company  grants stock options  to provide  equity
incentives. The Company has granted stock options under the 1983 Incentive Stock
Option Plan (expired by its terms on March 5, 1993), the 1986 Supplemental Stock
Option  Plan (expired by its terms on  January 16, 1996), the 1989 Director Plan
(expired by its terms  on June 30, 1994)  and the Incentive Plan  (collectively,
the "Plans"). Each of the Plans has been approved by the Company's stockholders.
 
    The  Company  has  granted  stock  options  to  persons  meeting eligibility
requirements of  each  Plan,  and  will  continue  granting  options  under  the
Incentive  Plan  until its  expiration or  when no  shares remain  available for
issuance. Options generally  vest over a  five-year period. As  of December  31,
1995,  there  were  outstanding  options to  purchase  3,831,543  shares  of the
Company's Common Stock under  the Plans, and  477,887 shares remained  available
for future issuance.
 
                                       8
<PAGE>
    The Incentive Plan provides that the Board or the Compensation Committee may
include  a provision  in any  stock option entitling  the optionee  to a further
option in the event the optionee exercises such option, in whole or in part,  by
surrendering  other  shares of  Common Stock  held by  the optionee  (a "Re-Load
Option"). No Re-Load Options have been  granted, and it is not anticipated  that
any Re-Load Options will be granted in the near future. The Company has no stock
appreciation rights.
 
    In  the  case of  any change  of control  of the  Company, (i)  all unvested
options granted  under the  Plans shall  vest immediately  unless the  acquiring
company  assumes  the  options  or substitutes  similar  options,  and  (ii) all
unvested options granted  under the  Plans shall  fully vest  if the  optionee's
employment  with the surviving corporation is  terminated within one year of the
change of control other than for cause. Options granted to Directors pursuant to
the Director Plans contain  comparable provisions in the  event that a  Director
does not remain on the Board of the surviving corporation.
 
    The  following  table  provides information  on  stock options  held  by the
executive  officers  named   in  the  Summary   Compensation  Table,   including
information  as to grants and  exercises for the fiscal  year ended December 31,
1995.
 
                       OPTION GRANTS IN LAST FISCAL YEAR
 
<TABLE>
<CAPTION>
                            INDIVIDUAL GRANTS
- -------------------------------------------------------------------------
                         NO. OF                                                 POTENTIAL REALIZABLE VALUE
                       SECURITIES    % OF TOTAL                                 AT ASSUMED ANNUAL RATES OF
                       UNDERLYING     OPTIONS                                    STOCK PRICE APPRECIATION
                         OPTIONS     GRANTED TO   EXERCISE OR                        FOR OPTION TERM
                       GRANTED(1)   EMPLOYEES IN  BASE PRICE   EXPIRATION  ------------------------------------
NAME                       (#)      FISCAL YEAR     ($/SH)        DATE         0%($)        5%($)      10%($)
- ---------------------  -----------  ------------  -----------  ----------     ------      ---------  ----------
<S>                    <C>          <C>           <C>          <C>         <C>            <C>        <C>
R. Casey                  120,000        15.78%    $    7.50    02/05/05             0    $ 566,005  $1,434,368
E. Grossbard               39,000         5.13%    $    7.50    02/05/05             0    $ 183,952  $  466,170
J. Lewicki                 39,000         5.13%    $    7.50    02/05/05             0    $ 183,952  $  466,170
A. Morris                  40,100         5.25%    $    7.50    02/05/05             0    $ 189,140  $  479,318
A. Ramel                   37,000         4.86%    $    7.50    02/05/05             0    $ 174,518  $  442,263
</TABLE>
 
- ------------------------
(1) These options vest in  equal monthly installments  commencing on January  1,
    1998 and ending on December 31, 1999.
 
                AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                            AND FY-END OPTION VALUES
 
<TABLE>
<CAPTION>
                                                            NUMBER OF SECURITIES
                                                           UNDERLYING UNEXERCISED     VALUE OF UNEXERCISED, IN-THE- MONEY
                        SHARES ACQUIRED       VALUE          OPTIONS AT FY-END          OPTIONS AT FY-END EXERCISABLE(1)
NAME                      ON EXERCISE       REALIZED     EXERCISABLE UNEXERCISABLE              UNEXERCISABLE(1)
- ---------------------  -----------------  -------------  --------------------------  --------------------------------------
<S>                    <C>                <C>            <C>          <C>            <C>                <C>
                              (#)              ($)                  (#)                               ($)
R. Casey                           0                0       420,000        240,000               0                   0
E. Grossbard                       0                0       124,000         95,000               0                   0
J. Lewicki                         0                0       140,000         79,000               0                   0
A. Morris                          0                0        39,298         70,802               0                   0
A. Ramel                           0                0        40,277         71,723               0                   0
</TABLE>
 
- ------------------------
(1) Based on the fair market value of the Company's Common Stock at December 29,
    1995 ($4.3125) minus the exercise price of the options.
 
                                       9
<PAGE>
                        COMPENSATION COMMITTEE REPORT(1)
 
    The  Compensation Committee of  the Board of  Directors (the "Committee") is
responsible  for  establishing  the  Company's  compensation  programs  for  all
employees, including executives. For executive officers, the Committee evaluates
performance  and  determines  compensation  policies and  levels.  In  1995, the
Committee was composed of  Mr. Armacost, Mr.  Du Bain and  Mr. O'Neill, none  of
whom were officers or employees of the Company.
 
COMPENSATION PHILOSOPHY
 
    The  goals  of  the  compensation program  are  to  align  compensation with
business objectives  and performance,  and  to enable  the Company  to  attract,
retain  and reward executive officers and  other key employees who contribute to
the long-term success of the Company  and to motivate them to enhance  long-term
stockholder value. Key elements of this philosophy are:
 
    - The  Company pays competitively with  leading biotechnology companies with
      which the Company competes for talent. To ensure that pay is  competitive,
      the  Company regularly compares its pay practices with these companies and
      sets its pay parameters based on this review.
 
    - The Company maintains annual incentive opportunities sufficient to provide
      motivation to achieve  specific operating  goals and  to generate  rewards
      that bring total compensation to competitive levels.
 
    - The  Company provides  significant equity-based  incentives for executives
      and other key employees  to ensure that they  are motivated over the  long
      term  to respond to the Company's business challenges and opportunities as
      owners and not just as employees.
 
    The primary components  of executive  compensation are  base salary,  annual
incentives  and  long-term equity  incentives. Over  the  last three  years, the
Committee has not granted a  salary increase to the  CEO and has granted  modest
increases  in  only one  year  to other  executives.  These actions  reflect the
Committee's intent to lower the relative percentage of fixed compensation  (base
salary)  and increase the  relative percentage of  variable pay or  pay based on
performance (annual and long-term equity incentives).
 
    The Committee's objective in general is  to set each component of  executive
compensation at the market average when compared to a group of leading companies
in  the biotechnology industry of comparable size  who compete in the job market
for individuals with the skills desired by the Company (the "comparator group").
The companies chosen  for the  comparator group used  for compensation  purposes
include  several of the companies which comprise the published industry index in
the Performance Graph included  in this Proxy  Statement. Because the  Committee
believes that the Company's most direct competitors for executive talent are not
necessarily  all of the companies  in the broad industry  index, many smaller or
earlier stage companies included in the index are not included in the comparator
group.
 
    BASE SALARY.  The Committee  annually reviews each executive officer's  base
salary  against the base salaries paid for similar positions by companies within
the comparator group. A range of salary levels is established by this comparison
centered on the 50th  percentile salary in the  comparator group for  comparable
positions.  Within this  range, the Committee  subjectively considers individual
factors,  including  individual  performance,  level  of  responsibility,  prior
experience,  breadth of knowledge and competitive  pay practices, as well as the
extent to which the Company achieved  its corporate objectives described in  the
section  below  entitled  ANNUAL  INCENTIVE. From  year  to  year,  the relative
weighting of
 
- ------------------------
(1) Notwithstanding anything to the contrary set  forth in any of the  Company's
    previous  filings  under the  Securities  Act of  1933,  as amended,  or the
    Exchange Act that might incorporate by reference future filings in whole  or
    in  part,  including  this  Proxy Statement,  neither  this  Report  nor the
    Performance Graph in this Proxy Statement shall be incorporated by reference
    into any such filings.
 
                                       10
<PAGE>
the individual components  and the  corporate performance  component may  differ
from  officer to officer, and can be expected to change over time in response to
the Company's development stage and the evolution of the biotechnology industry.
Actual base salaries  in 1995 remained  at the median  level for the  comparator
group.
 
    ANNUAL  INCENTIVE.   The Senior  Staff Incentive  Plan, an  annual incentive
award plan, is the variable pay  program for officers and other senior  managers
of  the Company  to earn  additional annual  compensation. The  actual incentive
award earned depends on the extent  to which Company and individual  performance
objectives  are achieved. At the start of  each year, the Committee and the full
Board of Directors review and approve the annual performance objectives for  the
Company  and individual officers.  The Company objectives  consist of operating,
strategic and  financial  goals  that  are considered  to  be  critical  to  the
Company's  fundamental long-term goal --  building stockholder value. For fiscal
1995, these objectives, listed in order of relative importance, were:
 
    - clinical milestones for key products currently in human clinical testing
 
    - preclinical milestones  for products  being considered  as candidates  for
      clinical testing
 
    - securing commercial partners for certain of the Company's technologies and
      commercial operations
 
    - financial  performance  related  to  the  Company's  cash  utilization and
      expanding the  sales and  profits derived  from the  Company's  commercial
      operations  group,  which markets  certain  products to  psychiatrists and
      mental health clinics
 
    - understanding, identifying  and developing  additional products  from  the
      Company's research pipeline as candidates for clinical testing
 
    After  the end of the year, the  Committee evaluates the degree to which the
Company has  met  its  objectives  and, at  the  discretion  of  the  Committee,
establishes  a total incentive award pool  under the SSI Plan. Individual awards
are determined by evaluating the Company's overall performance and by evaluating
each participant's performance  against objectives for  the year. The  incentive
award  pool  is then  allocated based  on the  assessment of  each participant's
contribution to achievement of corporate  and individual objectives. Awards  are
paid  in  cash  and  distributions  are  made  in  the  February  following  the
performance year.
 
    The Committee recently determined that  the Company achieved only a  portion
of  the key corporate  objectives for fiscal  1995 that are  outlined above. Key
objectives not  met included  the failure  to file  a New  Drug Application  for
AURICULIN-Registered  Trademark- anaritide,  not completing  new agreements with
corporate partners, and  failing to achieve  the cash utilization  goal and  the
goal  for expansion  of sales and  profits derived from  the Company's marketing
group. Goals  met  included advancement  of  the clinical  development  of  both
NATRECOR-Registered  Trademark- BNP and FIBLAST-Registered Trademark- trafermin,
preclinical work on a new proprietary compound and demonstrating efficacy of new
compounds in relevant models. Based on the Company's performance, the  Committee
determined that the total incentive pool for the 38 participants in the SSI Plan
would be 30% of the maximum possible pool. Based on its assessment of individual
contribution   to  achievement  of  corporate  and  individual  objectives,  the
Committee then  determined  the 1995  incentive  award  for each  of  the  seven
executives  on the Company's corporate  management committee. Mr. Casey received
no incentive award for 1995. See "Chief Executive Officer Compensation."
 
    LONG-TERM INCENTIVES.  The Company's long-term incentive program consists of
the 1983 Incentive Stock Option Plan, which  expired on March 5, 1993, the  1986
Supplemental  Stock Option Plan, which expired on January 16, 1996, and the 1992
Equity Incentive Plan.  The option program  utilizes vesting periods  (generally
four  to five years) to encourage key employees to continue in the employ of the
Company. Through option grants, executives receive significant equity incentives
to build long-term stockholder value. Grants have been made at or above 100%  of
fair  market value  on the  date of grant.  Executives receive  value from these
grants only if the Company's Common Stock appreciates
 
                                       11
<PAGE>
over the long term. The size of option grants is determined based on competitive
practices at companies in the comparator  group and the Company's philosophy  of
significantly  linking  executive  compensation with  stockholder  interests. In
addition, the Committee  considers the  terms and number  of options  previously
awarded in determining the size of option grants.
 
    In  1992, the  Committee granted  stock options  that vest  over a five-year
period to executives then employed by the Company. Such grants were intended  to
provide  incentive to successfully complete the merger with Nova and to maximize
stockholder value over the next several  years. Except for the extension of  the
terms  of the Affected Options that the Committee approved as part of the effort
to equalize  treatment of  employees after  the merger,  which included  certain
executive  officers, executives who received grants  in 1992 were not to receive
additional stock option grants until 1995.  In 1995, the Committee reviewed  the
equity  incentives of  executive officers and  made additional  grants to remain
competitive  with  the  comparator  group  and  maintain  appropriate  long-term
incentives  for key individuals. The 1995 grants will vest during 1998 and 1999.
The Committee believes the approach of making grants that vest over an  extended
time  period creates an appropriate focus on longer term objectives and promotes
executive retention.
 
    The Omnibus Budget Reconciliation Act of  1993 places a limit on the  amount
of  certain types of compensation for each of the executive officers that may be
tax deductible by the Company beginning in 1994. In December 1995, the  Internal
Revenue  Service  issued  final  regulations  on  the  deductibility  limit. The
Company's compensation is  currently subject  to certain  transition rules.  The
Company  does  not believe  these rules  will affect  it in  the near  term. The
Company plans to design and administer  its compensation plans in a manner  that
will not result in a limitation on the Company's compensation deduction.
 
CHIEF EXECUTIVE OFFICER COMPENSATION
 
    As  part of the merger with Nova in the fall of 1992, the Committee retained
Hewitt  Associates  (an   international  employee   compensation  and   benefits
consulting  firm) to  conduct a  comprehensive review  of the  base salaries and
incentive compensation of all continuing  executive officers as compared to  the
comparator  group. Following the Hewitt Associates review, the Committee set Mr.
Casey's base annual salary through 1993 at $400,000. This amount, in addition to
the annual  incentive provided  by the  SSI Plan,  was estimated  to provide  an
annual  cash  compensation level  at  the average  of  the comparator  group. In
setting this amount,  the Committee took  into account (i)  its belief that  Mr.
Casey is one of the CEOs of leading biotechnology companies with significant and
broad-based  experience in  the pharmaceutical industry,  (ii) the  scope of Mr.
Casey's responsibility, especially following the merger with Nova, and (iii) the
Board's confidence in Mr. Casey to lead the Company's continued development.
 
    For 1994, 1995 and 1996, the Committee elected to maintain Mr. Casey's  base
salary  at $400,000, the same level as 1993. In doing so, the Committee intended
to increase  the relative  portion of  Mr. Casey's  total compensation  that  is
variable pay, which is based on achievement of the corporate objectives annually
established by the Board and on increases in the Company's stock price.
 
    Notwithstanding  the Committee's determination to grant incentive awards for
1995 performance  to certain  other eligible  employees, the  Committee did  not
award  Mr. Casey an incentive  award for 1995. The  Committee determined that it
would instead enhance Mr. Casey's incentive to build long-term stockholder value
and, in  early 1996,  the Committee  granted  Mr. Casey  an option  to  purchase
100,000 shares of stock that will vest in the year 2000.
 
CONCLUSION
 
    In  summary, the Compensation Committee believes that, through the plans and
actions described above,  a significant  portion of  the Company's  compensation
program  and, in particular, Mr. Casey's  compensation are contingent on Company
performance, and that realization of  benefits is closely linked to  achievement
of key corporate objectives that will produce increases in long-term stockholder
value.  The Company remains committed to this philosophy of pay for performance,
recognizing that
 
                                       12
<PAGE>
the competitive  market  for  talented  executives and  the  volatility  of  the
Company's  business may result in highly  variable compensation for a particular
time  period.  We  will  continue  to  monitor  closely  the  effectiveness  and
appropriateness  of each of the components of compensation to reflect changes in
the Company's business environment.
 
                                            COMPENSATION COMMITTEE
                                            Donald E. O'Neill, Chairman
                                            Samuel H. Armacost
                                            Myron Du Bain
 
          COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
    From January  1, 1995  through March  30, 1995,  the Company's  Compensation
Committee  consisted of Mr. Goldby  (Chairman), Mr. Du Bain  and Mr. O'Neill. In
1995, the  Company  paid MDL  Information  Systems, Inc.  ("MDL")  approximately
$63,300  in connection with the purchase and maintenance of software made in the
normal course of business. Mr. Goldby is President, Chief Executive Officer  and
a director of MDL, and Mr. O'Neill is a director of MDL.
 
    In  1995, Scios paid $78,519  in portfolio management fees  to Weiss, Peck &
Greer, L.L.P., an  investment firm of  which Mr. Armacost  is a principal.  Such
fees were paid in the normal course of business.
 
                                       13
<PAGE>
                               PERFORMANCE GRAPH
 
    The rules of the Securities and Exchange Commission require that the Company
include  in this Proxy  Statement a line-graph  presentation comparing five-year
stockholder returns on an indexed basis with the NASDAQ Stock Market (U.S.)  and
either  a  nationally recognized  industry standard  index or  an index  of peer
companies selected by  the Company. The  Company has elected  to use the  NASDAQ
Pharmaceutical  Stocks  Index for  purpose  of the  performance  comparison that
appears below. The graph assumes the investment of $100 in the Company's  Common
Stock, the NASDAQ Stock Market (U.S.) and the NASDAQ Pharmaceutical Stocks Index
on  December 31, 1990. The  stock price performance shown  on the graph below is
not necessarily indicative of future price performance.
 
                COMPARISON OF FIVE YEAR CUMULATIVE TOTAL RETURN
                AMONG SCIOS INC., NASDAQ STOCK MARKET (U.S.) AND
                       NASDAQ PHARMACEUTICAL STOCKS INDEX
 
EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC
 
<TABLE>
<CAPTION>
           SCIOS NOVA    NASDAQ STOCK MARKET   NASDAQ PHARMACEUTICALS
<S>        <C>          <C>                    <C>
Dec-90          100.00                 100.00                   100.00
Jan-91          128.57                 111.09                   115.23
Feb-91          162.86                 121.77                   141.89
Mar-91          162.86                 129.92                   166.90
Apr-91          154.29                 130.74                   157.10
May-91          165.71                 136.74                   163.71
Jun-91          132.86                 128.41                   154.99
Jul-91          135.71                 136.02                   175.93
Aug-91          171.43                 142.78                   194.62
Sep-91          240.00                 143.30                   213.99
Oct-91          287.14                 148.04                   245.13
Nov-91          205.71                 143.07                   219.21
Dec-91          257.14                 160.55                   265.74
Jan-92          237.14                 169.94                   277.32
Feb-92          194.29                 173.79                   253.30
Mar-92          170.00                 165.59                   230.06
Apr-92          140.00                 158.48                   192.60
May-92          160.00                 160.54                   199.76
Jun-92          118.57                 154.27                   192.98
Jul-92          115.71                 159.73                   203.43
Aug-92          101.43                 154.85                   185.18
Sep-92           92.86                 160.61                   181.73
Oct-92           90.00                 166.93                   193.65
Nov-92          124.29                 180.22                   223.35
Dec-92          105.71                 186.85                   221.14
Jan-93           87.14                 192.17                   205.55
Feb-93           77.14                 185.00                   157.76
Mar-93           80.00                 190.36                   159.18
Apr-93           68.57                 182.23                   160.86
May-93           68.57                 193.12                   167.45
Jun-93           64.29                 194.01                   167.76
Jul-93           65.71                 194.24                   162.94
Aug-93           77.14                 204.28                   171.62
Sep-93           85.71                 210.37                   181.87
Oct-93          125.71                 215.09                   197.95
Nov-93          118.57                 208.68                   193.61
Dec-93          117.14                 214.50                   197.11
Jan-94          107.14                 221.01                   203.10
Feb-94           98.57                 218.94                   184.82
Mar-94           84.29                 205.48                   160.76
Apr-94           90.00                 202.81                   154.30
May-94           76.43                 203.31                   152.21
Jun-94           72.86                 195.87                   140.32
Jul-94           72.86                 199.89                   144.57
Aug-94           87.14                 212.63                   160.26
Sep-94           77.14                 212.09                   158.05
Oct-94           77.14                 216.25                   152.64
Nov-94           68.57                 209.08                   153.32
Dec-94           75.71                 209.67                   148.35
Jan-95           88.57                 210.77                   156.56
Feb-95           94.29                 221.91                   162.48
Mar-95           87.14                 228.49                   160.15
Apr-95           77.14                 235.69                   164.65
May-95           40.72                 241.77                   166.73
Jun-95           46.43                 261.36                   186.26
Jul-95           48.57                 280.57                   202.30
Aug-95           47.14                 286.25                   226.22
Sep-95           47.14                 292.87                   232.68
Oct-95           41.43                 291.19                   224.36
Nov-95           44.29                 298.03                   235.64
Dec-95           49.29                 296.51                   271.90
</TABLE>
 
                     CERTAIN RELATIONSHIPS AND TRANSACTIONS
 
    During 1993, the Company formed a new company, Guilford Pharmaceuticals Inc.
("Guilford"),  to  pursue  the   development  of  pharmaceutical  products   for
neurological  and neurosurgical applications. Dr.  Solomon H. Snyder, a Director
of the Company,  is a  founder and  a director  of Guilford.  Richard L.  Casey,
Chairman  of the Board and  Chief Executive Officer of  the Company, and John H.
Newman, Vice President  of Legal  Affairs of  the Company,  serve on  Guilford's
board  of  directors,  including  its  compensation  and  audit  committees.  In
addition, Arlene  M.  Morris, Vice  President  of Business  Development  of  the
Company,  served on  Guilford's board  from its  inception until  June 1994. The
Company initially received  a majority of  Guilford's stock in  exchange for  an
investment  of $2.5 million  in cash and cancellation  of indebtedness, plus the
transfer of certain  neuroscience technology originally  developed by Nova.  The
Company purchased additional Guilford stock, plus a warrant, for $1.0 million in
December  1993 and exercised the warrant  for $166,667 in January 1995. Guilford
completed its initial public offering of common stock in June 1994 and completed
a  follow-on  public  offering  in   August  1995.  Guilford  currently  has   a
registration  statement on file  with the Securities  and Exchange Commission in
anticipation of  another  follow-on  public  offering. As  of  March  18,  1996,
 
                                       14
<PAGE>
Dr.  Snyder beneficially  owned approximately 5.7%  of Guilford  and the Company
beneficially owned  approximately 16%  of  Guilford. Mr.  Casey and  Mr.  Newman
(after  disclaiming beneficial  ownership of  the Company's  shares in Guilford)
each beneficially own less than 1% of Guilford.
 
    During 1995, Guilford paid the Company approximately $213,435 for consulting
and administrative services and for temporary space provided to Guilford by  the
Company.
 
    Dr.  Snyder, the Company and Guilford were parties to a consulting agreement
whereby Dr.  Snyder received  consulting fees  from the  Company. The  agreement
terminated  in August  1995. See "Information  about the Board  of Directors and
Committees of the Board -- Compensation of Directors -- Other Arrangements."
 
    In November 1991, the Company made a commitment to loan up to $80,000 to Dr.
Elliott B.  Grossbard  in  connection  with his  joining  the  Company  as  Vice
President  of Medical and Regulatory Affairs.  The commitment was made to permit
Dr. Grossbard to  purchase a  residence. In June  1993, the  Company loaned  Dr.
Grossbard  $80,000, which loan  bears interest at  the annual rate  of 3.72%. On
each of May 31, 1994 and May  31, 1995, $25,000 was forgiven, and the  remaining
$30,000  will be forgiven on  May 31, 1996. The  loan balance is immediately due
and payable in the event Dr. Grossbard's employment terminates prior to May  31,
1996.
 
    Steven  D. Goldby and Donald E.  O'Neill are affiliated with MDL Information
Systems, Inc.,  with which  the  Company has  done business.  See  "Compensation
Committee Interlocks and Insider Participation."
 
    Samuel  H. Armacost is a  principal in the investment  firm of Weiss, Peck &
Greer, L.L.P. In 1995, Scios paid  $78,519 in portfolio management fees to  such
firm  in the normal  course of business.  See "Compensation Committee Interlocks
and Insider Participation."
 
                           (2) CORPORATE NAME CHANGE
 
    On February 6, 1996,  the Board of Directors  approved changing the name  of
the  Company to Scios Inc., and the Company  is now doing business under the new
name. Stockholders are requested to ratify and approve the name change, together
with the  related  filing  of  an amendment  to  the  Company's  Certificate  of
Incorporation.  This matter will require  the affirmative vote of  at least of a
majority of the shares  of Common Stock  represented in person  or by proxy  and
entitled to vote at the Annual Meeting.
 
THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL 2.
 
                    (3) RATIFICATION OF INDEPENDENT AUDITORS
 
    Upon  recommendation of the  Audit Committee, the Board  of Directors of the
Company appointed  Coopers &  Lybrand  L.L.P. to  be the  Company's  independent
auditors for the fiscal year ending December 31, 1996.
 
    Services  provided to the Company and  its subsidiaries by Coopers & Lybrand
with respect to the fiscal year ended December 31, 1995 included examination  of
the  Company's consolidated  financial statements, limited  reviews of quarterly
reports, services related to filings with the SEC, and consultations  concerning
information systems and various tax matters.
 
    Coopers  & Lybrand has  audited the Company's  financial statements annually
since the Company's inception in 1982. Representatives of Coopers & Lybrand  are
expected  to be  present at  the Annual Meeting.  They do  not expect  to make a
statement, but will have the opportunity to  make a statement if they desire  to
do so and will be available to respond to appropriate questions.
 
    Stockholder  ratification  of  the selection  of  Coopers &  Lybrand  as the
Company's independent  auditors  is not  required  by the  Company's  Bylaws  or
otherwise.  However, the Board is submitting  the selection of Coopers & Lybrand
to  the  stockholders   for  ratification   as  a  matter   of  good   corporate
 
                                       15
<PAGE>
practice.  If the  stockholders fail  to ratify  this selection,  the Board will
reconsider whether  or  not  to retain  that  firm.  Even if  the  selection  is
ratified,  the Board in its discretion may direct the appointment of a different
independent accounting firm at any time during the year if the Board feels  that
such  a  change  would  be  in  the  best  interests  of  the  Company  and  its
stockholders.
 
    Ratification of  the  selection  of  Coopers  &  Lybrand  as  the  Company's
independent  auditors for fiscal year 1996  will require the affirmative vote of
at least a majority of  the shares of Common Stock  represented in person or  by
proxy and entitled to vote at the Annual Meeting.
 
THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL 3.
 
                            (4) STOCKHOLDER PROPOSAL
 
    The  Company has received a  proposal submitted by Robert  G. Heft, III, 305
Watson Drive, Fort Walton Beach, Florida 32548, who has indicated that he is the
beneficial owner of  4,000 shares of  the Company's Common  Stock. The Board  of
Directors  disclaims any responsibility for the  content of the proposal and the
accompanying supporting  statement, which  are presented  as received  from  the
stockholder. The proposal is as follows:
 
        "RESOLVED,  that  the stockholders  of Scios  Nova Inc.  (The 'Company')
    hereby propose and request that the Board of Directors (the 'Board') of  the
    Company  take the  steps necessary  to appoint  a special  committee for the
    purpose of completing an aggressive and exhaustive search for a buyer of the
    Company. The committee's activities should include but not be limited to: a)
    soliciting, reviewing and negotiating offers to acquire the Company in [sic]
    terms that are fair and in the best interests of the Company's  stockholders
    and  that maximize the value of the stockholders' investment in the Company,
    and b) providing the  Company's stockholders with  quarterly reports on  the
    committee's progress."
 
Supporting Statement of Stockholder
    "It  is  my  belief and  concern  that  current senior  management  has been
directly responsible for  the consistent  sub par performance  of the  Company's
business  activities and that  this has caused the  continued under valuation of
stock and each shareholder's ownership in  the Company. I believe that the  only
available  option left  that will maximize  future shareholder value  is to take
aggressive action to  seek a buyer  for the  Company. I propose  that the  Board
create a task force committee to solicit offers for the purchase of the Company.
During the recent past, buyout offers have been made for other biotech companies
at  a substantial premium to  their stock prices and it  appears that this is an
opportune time for achieving this objective. A VOTE FOR THIS PROPOSAL would best
serve the interests of stockholders."
 
Opposing Statement of the Board of Directors
    It is the Board's strong belief that the adoption of the foregoing  proposal
is not in the best interests of the Company's stockholders and that, rather than
maximizing  stockholder value,  its adoption  would actually  reduce stockholder
value. In recommending a  vote against the proposal,  the Board recognizes  that
its inherent mandate is to maximize the value of the stockholders' investment.
 
    The  proposal would direct the Board to pursue one strategic alternative: to
put the Company up for  sale. The Board believes that  this proposal to put  the
Company  "in play" without a  strategic plan is inherently  bad business. If the
Board is forced  to function  under a  stockholder-imposed mandate  to sell  the
Company,  the Board's ability to negotiate in  confidence and from a position of
strength will be seriously compromised. At the same time, the uncertainty  about
the Company's future would be likely to adversely impact business and operations
as a result of the loss of potential and existing corporate partners, customers,
vendors,  key employees and others. This is  likely to lead to unnecessary stock
price volatility and seriously compromise day-to-day management of the  Company.
The   Board  believes  that  a  forced   sale,  rather  than  adding  value  for
stockholders, would actually decrease value for stockholders.
 
                                       16
<PAGE>
    An identical proposal was submitted to  stockholder vote at the 1994  annual
meeting   of  stockholders.  The  1994  proposal  was  defeated  by  a  vote  of
approximately 83% of shares voting at that meeting. The Board believes that  the
defeat  in  1994 resoundingly  demonstrates  that the  overwhelming  majority of
stockholders are aligned with the Board in its assessment that this proposal  is
not in the best interest of stockholders.
 
    The  proponent implies that the Board  has ignored opportunities to maximize
the value of stockholders'  investment. The Board  and the Company's  management
are committed to increasing stockholder value and, in line with this commitment,
the  Board regularly evaluates available options and overall corporate strategy.
As part of fulfilling its fiduciary duty, the Board has considered all available
options, including the  sale of  the Company.  Based on  careful and  considered
review of viable corporate strategies, the specific actions that the Company has
taken  in the last few years include the decisions for the Company: to focus its
own efforts only on acute-care products; to reduce the work force as a result of
the acute-care  focus;  to form  Guilford  Pharmaceuticals, which  is  currently
developing   technologies  formerly   under  development  by   the  Company;  to
consolidate  and  strengthen  its  R&D  efforts  by  moving  its  Baltimore  R&D
operations  to California;  and to  identify non-acute  care technologies  to be
developed with commercial  partners. The Company  believes that these  decisions
and  actions have keenly focused  the Company on objectives  that offer the best
opportunity to maximize stockholder value. In addition, the Board believes  that
pursuing  these strategies as an independent company offer the best prospects at
this time for increasing stockholder value. For instance, the Company formed and
invested in Guilford in order to take full advantage of technologies acquired in
the merger with Nova. Guilford has since  become a public company and the  value
of  the Company's investment has increased substantially. In fact, the Company's
total cash investment in Guilford of  approximately $3.7 million has risen to  a
value  of approximately  $25 million,  based on  Guilford's stock  price in mid-
March.
 
    Finally, the  proposal would  mandate  a special  committee to  conduct  "an
aggressive  and exhaustive search  for a buyer  of the Company,"  and to provide
quarterly reports to stockholders. The proposal is extremely vague as to what is
meant by the term "special committee"  and how such a committee would  function.
Currently,  six out of seven members of the Board are independent directors. The
proposal is not  clear as  to why the  Board as  a whole cannot  deal with  such
matters, as it now does. The proposal does not address pertinent issues such as:
(i)  who would serve on such a committee; (ii) what criteria the committee would
use in evaluating  offers of  potential buyers;  (iii) how  the committee  would
interact  with  the  Board;  (iv)  how it  would  provide  quarterly  reports to
stockholders and at whose expense; (v)  whether or not the committee would  have
access  to non-public  information; (vi)  how long  efforts to  sell the Company
would continue; and (vii) who would have the ultimate decision-making  authority
with  respect  to  decisions regarding  the  sale  of the  Company.  Because the
proposal  is  so  unclear,  stockholders   are  required  to  guess  about   the
consequences   of  the  proposal   on  which  they   are  voting.  In  addition,
implementation of the proposal would entail significant additional costs for the
Company.
 
    The Board  and  the  Company's  management will  continue  to  consider  all
opportunities  for increasing stockholder value.  The Board firmly believes that
the Company  has been  proactive in  analyzing all  strategic alternatives.  The
proposal  does  not provide  sufficient  information to  enable  stockholders to
determine the practical implications of a vote for the proposal. The proposal is
counterproductive to stockholders' interests and, if approved, would serve  only
to  inhibit  the Board  and management  from pursuing  their main  objective: to
maximize stockholder value.
 
THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE AGAINST PROPOSAL 4
 
                                       17
<PAGE>
                                 OTHER MATTERS
 
    The Board of Directors does not know  of other matters that may come  before
the  meeting.  However,  if any  other  matters  are properly  presented  to the
meeting, it is the intention of the  persons named in the accompanying proxy  to
vote, or otherwise to act, in accordance with their judgment on such matters.
 
                  STOCKHOLDER PROPOSALS - 1997 ANNUAL MEETING
 
    Stockholders  are entitled to present proposals  for action at a forthcoming
stockholder meeting if  they comply with  the requirements of  the proxy  rules.
Proposals  of stockholders  that are intended  to be presented  at the Company's
1997 Annual Meeting  of Stockholders must  be received by  the Company no  later
than  November 26, 1996 in order to be included in the proxy statement and proxy
relating to that meeting.
 
                                          By Order of the Board of Directors
 
                                          JOHN H. NEWMAN
                                          SECRETARY
 
March 26, 1996
 
THE BOARD OF DIRECTORS HOPES THAT STOCKHOLDERS WILL ATTEND THIS MEETING. WHETHER
OR NOT  YOU PLAN  TO ATTEND,  YOU ARE  URGED TO  COMPLETE, SIGN  AND RETURN  THE
ENCLOSED PROXY IN THE ACCOMPANYING ENVELOPE. STOCKHOLDERS WHO ATTEND THE MEETING
MAY VOTE THEIR SHARES PERSONALLY EVEN THOUGH THEY HAVE SENT IN THEIR PROXIES.
 
                                       18



<PAGE>


                                    DETACH HERE


                                    SCIOS INC.

              PROXY FOR ANNUAL MEETING OF STOCKHOLDERS MAY 14, 1996
        
            THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

P  
R
O          The undersigned hereby appoints Richard L. Casey and John H. Newman,
X     or either of them, each with full power of substitution, as proxies
Y     of the undersigned, to attend the Annual Meeting of Stockholders of 
      Scios Inc., to be held at the offices of the Company, 2450 Bayshore 
      Parkway, Mountain View, California, on May 14, 1996 at 10:00 a.m. and at
      any adjournment or postponement thereof, to vote the number of shares 
      the undersigned would be entitled to vote if personally present, and to 
      vote in their discretion upon any other business that may properly come 
      before the meeting.

            THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED IN THE MANNER 
      DIRECTED HEREIN. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED FOR 
      PROPOSALS 1, 2 AND 3 AND AGAINST PROPOSAL 4.
 
            Please sign, date and return this proxy in the envelope provided, 
       which requires no postage if mailed in the United States.


                                                             ___________
                                                            
                                                             SEE REVERSE
             CONTINUED AND TO BE SIGNED ON REVERSE SIDE         SIDE
                                                             ___________  





<PAGE>



                                 DETACH HERE

      PLEASE MARK
/ X / VOTES AS IN
      THIS EXAMPLE

- ------------------------------------------------------------------------------
            THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR PROPOSALS 1, 2 AND 3.
- -------------------------------------------------------------------------------

1. Election of Directors.
NOMINEES: Samuel H. Armacost, Richard L. Casey, Myron Du Bain, Robert W. 
Schrier, Burton E. Sobel, Solomon H. Snyder, Eugene L. Step

                        FOR           WITHHELD 
                        / /             / /

/ / __________________________________________
 For all nominees except as noted above


 MARK HERE IF YOU PLAN TO ATTEND THE MEETING / /

 MARK HERE FOR ADDRESS CHANGE AND NOTE BELOW / /

2. To ratify and approve an ammendment to 
   the Company's Certificate of Incorporation      FOR   AGAINST   ABSTAIN
   to change the Company's name to Scios Inc.      / /     / /        / / 

3. To ratify the selection of Coopers &
   Lybrand LLP as the Company's Independent        FOR    AGAINST   ABSTAIN
   auditors for fiscal 1996.                       / /      / /       / /  

- -------------------------------------------------------------------------------
                 The Board of Directors recommends a vote
                     AGAINST stockholder proposal 4.
- -------------------------------------------------------------------------------
4. Stockholder proposal regarding                FOR    AGAINST   ABSTAIN
   Committee to seek Buyer.                         / /      / /       / /  
- -------------------------------------------------------------------------------

(Please sign exactly as name appears. When shares are held by joint tenants, 
both should sign. When signing as attorney, as executor, administrator, 
trustee or guardian, please give full title as such. If a corporation, please 
sign in full corporate name by President or other authorized officer. If a 
partnership, please sign in partnership name by authorized person.)



Signature:________________ Date:________ Signature:_________________ Date:_____




© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission