SCIOS INC
S-8, 1997-09-09
DRUGS, PROPRIETARIES & DRUGGISTS' SUNDRIES
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      As filed with the Securities and Exchange Commission on September 9, 1997
                                                      Registration No. 33-


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                               ------------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933
                               ------------------

                                   Scios Inc.
             (Exact name of registrant as specified in its charter)
                               -----------------


           Delaware                                       95-3701481
(State or other jurisdiction of                        (I.R.S. Employer
 incorporation or organization)                     Identification Number)


                               ------------------

                              2450 Bayshore Parkway
                             Mountain View, CA 94043
                    (Address of Principal Executive Offices)
                               ------------------

                  Scios Inc. 1996 Non-Officer Stock Option Plan
                      Scios Inc. 1992 Equity Incentive Plan
                            (Full title of the plans)
                               ------------------

                              John H. Newman, Esq.
                  Vice President, General Counsel and Secretary
                                   Scios Inc.
                              2450 Bayshore Parkway
                             Mountain View, CA 94043
                                 (650) 966-1550
       (Name, address, including zip code, and telephone number, including
                        area code, of agent for service)
                               ------------------




<TABLE>
<CAPTION>

                         CALCULATION OF REGISTRATION FEE
- --------------------------------------------------------------------------------
                                                       Proposed
      Title of                  Proposed                Maximum
  Securities to be          Maximum Amount to       Offering Price            Aggregate              Amount of
     Registered               be Registered          Per Share(1)         Offering Price(1)     Registration Fee(2)
======================== ====================== ====================== ====================== ======================
<S>                      <C>                    <C>                    <C>                    <C>

Common Stock
(par value $.001)              2,200,000              $7.09375              $15,606,250             $4,729.17
======================== ====================== ====================== ====================== ======================
<FN>
(1)  Pursuant to Rule 457(h)  under the  Securities  Act of 1933,  the  offering
     price per share and aggregate  offering price are based upon the average of
     the high and low prices of the Registrant's Common Stock as reported on the
     Nasdaq National Market for September 5, 1997 for shares reserved for future
     grant pursuant to the 1992 Equity Incentive Plan (1,500,000 shares) and the
     1996 Non-Officer Stock Option Plan (700,000 shares).
(2)  Estimated  solely  for  the  purpose  of  calculating  the  amount  of  the
     Registration  Fee based upon the  average of the high and low prices of the
     Registrant's  Common  Stock as reported on the Nasdaq  National  Market for
     September 5, 1997.
</FN>
</TABLE>



<PAGE>


                 INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE


         The following  documents  filed by Scios Inc. (the  "Company") with the
Securities  and Exchange  Commission  are  incorporated  by reference  into this
Registration Statement:

         1. The Company's  latest  annual report on Form 10-K filed  pursuant to
Sections 13(a) or 15(d) of the Securities  Exchange Act of 1934, as amended (the
"Exchange Act"), or either (1) the Company's latest prospectus filed pursuant to
Rule 424(b) under the  Securities  Act of 1933,  as amended  (the  "Act"),  that
contains audited  financial  statements for the Company's latest fiscal year for
which  such  statements  have  been  filed,  or  (2)  the  Company's   effective
registration  statement  on  Form  10 or  20-F  filed  under  the  Exchange  Act
containing audited financial statements for the Company's latest fiscal year.

         2. All other reports filed  pursuant to Sections  13(a) or 15(d) of the
Exchange Act since the end of the fiscal year covered by the annual reports, the
prospectus or the registration statement referred to in (a) above.

         3. The description of the Company's  Common Stock which is contained in
a registration  statement filed under the Exchange Act,  including any amendment
or report filed for the purpose of updating such description.

         All  reports  and other  documents  subsequently  filed by the  Company
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the
filing of a post-effective amendment which indicates that all securities offered
have been sold or which deregisters all securities then remaining unsold,  shall
be  deemed  to be  incorporated  by  reference  herein  and to be a part of this
registration  statement  from  the  date  of the  filing  of  such  reports  and
documents.



                    INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Under Section 145 of the Delaware  General  Corporation Law the Company
has broad powers to indemnify  its directors  and officers  against  liabilities
they may incur in such capacities,  including  liabilities  under the Securities
Act. The  Company's  Bylaws  require the Company to indemnify  its directors and
executive  officers  and may  indemnify  its other  officers  to the full extent
permitted by law. The Company  believes  that  indemnification  under its Bylaws
covers at least negligence and gross  negligence by officers and directors,  and
requires the Company to advance  litigation  expenses in the case of stockholder
derivative  actions or other  actions,  against an undertaking by the officer or
director to repay such advances if it is ultimately  determined that the officer
or director is not entitled to indemnification.  The Bylaws further provide that
rights  conferred  under such Bylaws  shall not be deemed to be exclusive of any
other right such persons may have or acquire under any statute, provision of any
Certificate  of   Incorporation,   Bylaw,   agreement,   vote  of  stockholders,
disinterested directors or otherwise.

         In  addition,  the  Company's  Restated  Certificate  of  Incorporation
provides that,  pursuant to Delaware law, its directors  shall not be liable for
monetary  damages  for breach of the  directors'  fiduciary  duty of care to the
Company and its stockholders. This provision in the Certificate of Incorporation
does not eliminate the duty of care, and in appropriate  circumstances equitable
remedies such as injunctive  or other forms of  non-monetary  relief will remain
available  under  Delaware  law. In addition,  each director will continue to be
subject  to  liability  for  breach of the  director's  duty of  loyalty  to the
Company,  for  acts or  omissions  not in good  faith or  involving  intentional
misconduct,  for knowing  violations  of law,  for  actions  leading to improper
personal  benefit to the  director,  and for payment of dividends or approval of
stock  repurchases  or  redemptions  that are unlawful  under  Delaware law. The
provision  also does not affect a  director's  responsibilities  under any other
law, such as the federal securities laws or state or federal environmental laws.

         The Company  has entered  into  indemnity  agreements  with each of its
directors and executive  officers.  The Company currently has a policy providing
directors and officers liability  insurance which insures directors and officers
of the Company in certain  circumstances.  The policy  also  insures the Company
against  losses  as  to  which  its  directors  and  officers  are  entitled  to
indemnification.



                                    EXHIBITS

Exhibit
Number

4.1          Restated  Certificate of  Incorporation  of Scios Inc..  (Filed as
             an exhibit to Annual Report on Form 10-K for fiscal year 1994 and
             incorporated herein by reference.)

4.2          Restated  Bylaws of Scios  Inc..  (Filed as an exhibit to Form S-4
             Registration  Statement  (File No. 33-49846) filed on July 22, 1992
             and incorporated herein by reference.)

5.1          Opinion of John H. Newman,  Vice President,  General  Counsel and
             Secretary of the  Registrant,  as to the legality of shares being 
             registered.

23.1         Consent of Coopers & Lybrand L.L.P.

23.2         Consent of John H. Newman. Reference is made to Exhibit 5.1 of this
             Registration Statement.

24.1         Power of Attorney. Reference is made to page 5 of this Registration
             Statement.

99.1         1992 Equity Incentive Plan, as amended.  (Filed as Exhibit 10.11 to
             Quarterly  Report on Form 10-Q for the quarter ended June 10, 1997,
             filed August 14, 1997, and incorporated herein by reference.)

99.2         1996 Non-Officer Stock Option Plan.

99.3         Forms of option  agreements for 1992 Equity  Incentive Plan (Filed
             as an Exhibit to the  Registration Statement on Form S-8 (Reg. No.
             33-51590) and incorporated herein by reference).

99.4         Form of option agreement for 1996 Non-Officer Stock Option Plan.



                                  UNDERTAKINGS

      1.      The undersigned registrant hereby undertakes:

              (a) To file,  during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:

                   (i)   To include any prospectus required by section 10(a)(3)
of the Securities Act;

                  (ii) To reflect in the  prospectus any facts or events arising
after the  effective  date of the  registration  statement  (or the most  recent
post-effective  amendment  thereof)  which,  individually  or in the  aggregate,
represent a fundamental  change in the information set forth in the registration
statement.  Notwithstanding the foregoing, any increase or decrease in volume of
securities  offered (if the total dollar value of  securities  offered would not
exceed that which was  registered) and any deviation from the low or high end of
the estimated  maximum offering range may be reflected in the form of prospectus
filed with the Commission  pursuant to Rule 424(b) ('230.424(b) of this chapter)
if, in the aggregate,  the changes in volume and price  represent no more than a
20% change in the maximum aggregate offering price set forth in the "Calculation
of Registration Fee" table in the effective registration statement.

                 (iii) To include any material  information  with respect to the
plan of distribution not previously  disclosed in the registration  statement or
any material change to such information in the registration statement;

         Provided, however, that paragraphs 1(a)(i) and 1(a)(ii) do not apply if
the  registration  statement  is on  Form  S-3 or Form  S-8 and the  information
required to be included in a  post-effective  amendment by those  paragraphs  is
contained  in  periodic  reports  filed by the issuer  pursuant to section 13 or
section  15(d) of the  Exchange  Act that are  incorporated  by reference in the
registration statement.

              (b) That, for the purpose of determining  any liability  under the
Securities Act, each such  post-effective  amendment shall be deemed to be a new
registration  statement  relating  to the  securities  offered  herein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

              (c) To  remove  from  registration  by means  of a  post-effective
amendment  any of the  securities  being  registered  which remain unsold at the
termination of the offering.

         2. The undersigned  registrant  hereby undertakes that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Exchange Act (and, where  applicable,  each filing of an employee benefit plan's
annual  report   pursuant  to  section  15(d)  of  the  Exchange  Act)  that  is
incorporated by reference in the Registration  Statement shall be deemed to be a
new registration  statement  relating to the securities  offered herein, and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

         3.  Insofar  as  indemnification  for  liabilities  arising  under  the
Securities Act may be permitted to directors,  officers and controlling  persons
of the  registrant  pursuant to the  foregoing  provisions,  or  otherwise,  the
registrant  has been advised that in the opinion of the  Securities and Exchange
Commission  such  indemnification  is against  public policy as expressed in the
Securities Act and is, therefore,  unenforceable.  In the event that a claim for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against  public policy as expressed in the  Securities
Act and will be governed by the final adjudication of such issue.



<PAGE>




                                   SIGNATURES

         The Registrant.  Pursuant to the  requirements of the Securities Act of
1933, as amended,  the Registrant  certifies  that it has reasonable  grounds to
believe  that it meets all of the  requirements  for  filing on Form S-8 and has
duly  caused  this  Registration  Statement  to be signed  on its  behalf by the
undersigned,  thereunto duly authorized,  in the City of Mountain View, State of
California, on September 9, 1997.

                                   SCIOS INC.

                                   /s/ Richard L. Casey
                                   By ___________________________
                                      Richard L. Casey
                                      Chairman of the Board and
                                      Chief Executive Officer



                                POWER OF ATTORNEY

         KNOW ALL PERSONS BY THESE  PRESENTS,  that each person whose  signature
appears below  constitutes and appoints John H. Newman and Richard L. Casey, and
each or any one of them, his true and lawful  attorney-in-fact  and agent,  with
full power of substitution  and  resubstitution,  for him and in his name, place
and stead, in any and all capacities,  to sign any and all amendments (including
post-effective amendments) to this Registration Statement, and to file the same,
with all exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange  Commission,  granting unto said  attorneys-in-fact  and
agents,  and each of them,  full power and  authority to do and perform each and
every act and thing requisite and necessary to be done in connection  therewith,
as fully to all intents and  purposes as he might or could do in person,  hereby
ratifying and confirming all that said  attorneys-in-fact  and agents, or any of
them, or their or his substitutes or substitute,  may lawfully do or cause to be
done by virtue hereof.

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

Signature                    Title                             Date


/s/ Richard L. Casey         Chairman of the Board and         September 9, 1997
(Richard L. Casey)           Chief Executive Officer (Acting
                             Chief Financial Officer)


/s/ David Southern           Controller                        September 9, 1997
(David Southern)             (Acting Principal
                             Accounting Officer)


/s/ Samuel H. Armacost       Director                          September 9, 1997
(Samuel H. Armacost)


/s/ Myron Du Bain            Director                          September 9, 1997
(Myron Du Bain)


                             Director                          September _, 1997
(Donald B. Rice, Ph.D.)


/s/ Robert W. Schrier, M.D.  Director                          September 9, 1997
(Robert W. Schrier, M.D.)


/s/ Solomon H. Snyder, M.D.  Director                          September 9, 1997
(Solomon H. Snyder, M.D.)


/s/ Burton E. Sobel, M.D.    Director                          September 9, 1997
(Burton E. Sobel, M.D.)


/s/ Eugene L. Step           Director                          September 9, 1997
(Eugene L. Step)


<PAGE>




                                  EXHIBIT INDEX

    Exhibit
    Number       Description

      4.1        Restated Certificate of Incorporation of Scios Inc.  (Filed as
                 an exhibit to Annual Report on Form 10-K for fiscal year 1994
                 and incorporated herein by reference.)
      4.2        Restated Bylaws of Scios Inc. (Filed as an exhibit to Form S-4
                 Registration Statement (File No. 33-49846) filed on July 22,
                 1992 and incorporated herein by reference.)
      5.1        Opinion of John H. Newman, Vice President, General Counsel and
                 Secretary of the Registrant, as to the legality of shares being
                 registered.
     23.1        Consent of Coopers & Lybrand L.L.P..
     23.2        Consent of John H. Newman. Reference is made to Exhibit 5.1 of
                 this Registration Statement.
     24.1        Power of Attorney.  Reference is made to page 6 of this
                 Registration Statement.
     99.1        1992 Equity Incentive Plan, as amended. (Filed as Exhibit 10.11
                 to Form 10-Q (File No. 0-11749) on August 14, 1997 and
                 incorporated herein by reference.)
     99.2        1996 Non-Officer Stock Option Plan.
     99.3        Form of option agreement for 1992 Equity Incentive Plan (Filed
                 as an exhibit to the Registration Statement on Form S-8 (Reg.
                 No. 33-51590) and incorporated herein by reference.)
     99.4        Form of option agreement for 1996 Non-Officer Stock Option
                 Plan.











September 9, 1997





Scios Inc.
2450 Bayshore Parkway
Mountain View, CA  94043-1173

Ladies and Gentlemen:

You have requested my opinion with respect to certain matters in connection with
the filing by Scios Inc. (the "Company") of a Registration Statement on Form S-8
(the  "Registration  Statement")  with the  Securities  and Exchange  Commission
covering the offering of 2,200,000 shares the Company's Common Stock,  $.001 par
value (the  "Shares"),  with  respect to (a)  1,500,000  of the Shares  issuable
pursuant to its 1992 Equity  Incentive Plan, as amended,  and (b) 700,000 of the
shares   issuable   pursuant  to  its  1996   Non-Officer   Stock   Option  Plan
(collectively, the "Plans").

In connection with this opinion, I have examined the Registration  Statement and
related  prospectuses,  the Restated Certificate of Incorporation and Bylaws, as
amended, and such other documents,  records,  certificates,  memoranda and other
instruments as I deem necessary as a basis for this opinion.  I have assumed the
genuineness and authenticity of all documents submitted to me as originals,  the
conformity to originals of all documents submitted to me as copies thereof,  and
the due execution and delivery of all documents where due execution and delivery
are a prerequisite to the effectiveness thereof.

On the basis of the foregoing, and in reliance thereon, I am of the opinion that
the Shares,  when sold and issued in accordance with the Plans, the Registration
Statement and related  prospectuses,  will be validly  issued,  fully paid,  and
nonassessable.

I consent  to the  filing of this  opinion  as an  exhibit  to the  Registration
Statement.

Very truly yours,

/s/ John H. Newman

John H. Newman, Esq.





                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


We consent to the incorporation by reference in this Registration  Statement and
the  Registration  Statements of Scios Inc. on Form S-8 (File No. 2-90477,  File
No.  2-97606,  File No.  33-39878 and File No.  33-51590) and Form S-3 (File No.
33-18958)  of  our  report  dated  January  28,  1997,  on  our  audits  of  the
consolidated  financial statements of Scios Inc. and subsidiaries as of December
31, 1996 and 1995,  and for each of three years in the period ended December 31,
1996, which report is included in the Annual Report on Form 10-K.

                           /s/   COOPERS & LYBRAND L.L.P.



San Jose, California
September 8, 1997






                                   SCIOS INC.

                       1996 NON-OFFICER STOCK OPTION PLAN

                            Adopted November 11, 1996
                            Amended February 3, 1997


PURPOSES.

     The purpose of the Plan is to provide a means by which  selected  Employees
of and  Consultants  to the  Company,  and  its  Affiliates,  may  be  given  an
opportunity  to  benefit  from  increases  in value of the stock of the  Company
through the granting of (i) Nonstatutory Stock Options,  (ii) stock bonuses, and
(iii) rights to purchase restricted stock, all as defined below.

     The Company,  by means of the Plan, seeks to retain the services of persons
(other than  Directors and  Employees  serving as Officers of the Company or its
Affiliates)  who are now  Employees  of or  Consultants  to the  Company  or its
Affiliates,  to secure and retain the services of new Employees and Consultants,
and to provide  incentives  for such  persons to exert  maximum  efforts for the
success of the Company and its  Affiliates.  The Company  intends that the Stock
Awards  issued  under  the Plan  shall,  in the  discretion  of the Board or any
Committee  to  which  responsibility  for  administration  of the  Plan has been
delegated  pursuant to subsection 3(c), be either (i) Nonstatutory Stock Options
granted  pursuant  to  Section  6 hereof,  or (ii)  stock  bonuses  or rights to
purchase restricted stock granted pursuant to Section 7 hereof.

DEFINITIONS.

     "Affiliate" means any parent corporation or subsidiary corporation, whether
now or  hereafter  existing,  as those terms are defined in Sections  424(e) and
(f), respectively, of the Code.

         "Board" means the Board of Directors of the Company.

         "Code" means the Internal Revenue Code of 1986, as amended.

     "Committee"  means a Committee  appointed by the Board in  accordance  with
subsection 3(c) of the Plan.

          "Company" means Scios Inc., a Delaware corporation.

     "Consultant" means any person, including an advisor, engaged by the Company
or an Affiliate to render  consulting  services and who is compensated  for such
services,  provided that the term  "Consultant"  shall not include Directors who
are paid only a director's fee by the Company or who are not  compensated by the
Company for their services as Directors.

     "Continuous  Status as an Employee or Consultant" means that the service of
an  individual  to the  Company,  whether as an Employee or  Consultant,  is not
interrupted  or terminated.  The Board,  in its sole  discretion,  may determine
whether  Continuous  Status as an Employee  or  Consultant  shall be  considered
interrupted  in the case of:  (i) any leave of  absence  approved  by the Board,
including  sick leave,  military  leave,  or any other personal  leave;  or (ii)
transfers between locations of the Company or between the Company, Affiliates or
their successors.

     "Employee" means any person, including Officers, employed by the Company or
any Affiliate of the Company.

      "Exchange Act" means the Securities Exchange Act of 1934, as amended.

     "Fair  Market  Value" means the value of the common stock of the Company as
determined in good faith by the Board.

     "Nonstatutory  Stock  Option" means an Option not intended to qualify as an
incentive  stock option  pursuant to Section 422 of the Code and the regulations
promulgated thereunder.

     "Officer"  means a person  who is an  officer  of the  Company  within  the
meaning  of  Section  16 of the  Exchange  Act and  the  rules  and  regulations
promulgated thereunder.

     "Option" means a stock option granted pursuant to the Plan.

     "Option  Agreement"  means a written  agreement  between the Company and an
Optionee evidencing the terms and conditions of an individual Option grant. Each
Option Agreement shall be subject to the terms and conditions of the Plan.

       "Optionee" means a person who holds an outstanding Option.

       "Plan" means this 1996 Non-Officer Stock Option Plan.

     "Stock Award" means any right granted under the Plan, including any Option,
any stock bonus and any right to purchase restricted stock.

     "Stock Award Agreement" means a written agreement between the Company and a
holder of a Stock Award  evidencing  the terms and  conditions  of an individual
Stock Award grant.  Each Stock Award Agreement shall be subject to the terms and
conditions of the Plan.

ADMINISTRATION.

     The Plan  shall be  administered  by the Board  unless  and until the Board
delegates administration to a Committee, as provided in subsection 3(c).

     The Board shall have the power,  subject to, and within the limitations of,
the express provisions of the Plan:

     To determine from time to time which of the persons eligible under the Plan
shall be granted Stock  Awards;  when and how each Stock Award shall be granted;
whether a Stock Award will be a  Nonstatutory  Stock  Option,  a stock bonus,  a
right to purchase  restricted  stock,  or a combination  of the  foregoing;  the
provisions of each Stock Award granted (which need not be identical),  including
the time or times when a person shall be permitted to receive stock  pursuant to
a Stock  Award;  and the number of shares  with  respect to which a Stock  Award
shall be granted to each such person.

     To construe and interpret  the Plan and Stock Awards  granted under it, and
to establish, amend and revoke rules and regulations for its administration. The
Board,  in the  exercise  of this power,  may  correct  any defect,  omission or
inconsistency  in the Plan or in any Stock Award  Agreement,  in a manner and to
the  extent  it shall  deem  necessary  or  expedient  to make  the  Plan  fully
effective.

     To amend the Plan or a Stock Award as provided in Section 12.

     Generally,  to exercise  such powers and to perform  such acts as the Board
deems  necessary or expedient to promote the best interests of the Company which
are not in conflict with the provisions of the Plan.

     The Board may delegate  administration of the Plan to a committee  composed
of one or more  members of the Board (the  "Committee").  If  administration  is
delegated to a Committee,  the  Committee  shall have,  in  connection  with the
administration of the Plan, the powers  theretofore  possessed by the Board (and
references  in this Plan to the Board  shall  thereafter  be to the  Committee),
subject,  however, to such resolutions,  not inconsistent with the provisions of
the  Plan,  as may be  adopted  from  time to time by the  Board.  The Board may
abolish the Committee at any time and revest in the Board the  administration of
the Plan.

SHARES SUBJECT TO THE PLAN.

     Subject to the  provisions  of  Section 11  relating  to  adjustments  upon
changes in stock,  the stock that may be issued  pursuant to Stock  Awards shall
not exceed in the  aggregate  seven  hundred  thousand  (700,000)  shares of the
Company's  common  stock.  If any Stock  Award  shall for any  reason  expire or
otherwise terminate, in whole or in part, without having been exercised in full,
the stock not  acquired  under such Stock Award shall revert to and again become
available for issuance under the Plan.

     The stock subject to the Plan may be unissued shares or reacquired  shares,
bought on the market or otherwise.

ELIGIBILITY.

     Stock Awards may be granted only to  Employees or  Consultants  who (i) are
not Officers and (ii) are not then subject to Section 16 of the Exchange Act.

OPTION PROVISIONS.

     Each  Option  shall be in such  form  and  shall  contain  such  terms  and
conditions  as the Board  shall deem  appropriate.  The  provisions  of separate
Options  need  not  be  identical,   but  each  Option  shall  include  (through
incorporation of provisions  hereof by reference in the Option or otherwise) the
substance of each of the following provisions:

     Term. No Option shall be exercisable after the expiration of ten (10) years
from the date it was granted.

     Price.  The exercise price of each  Nonstatutory  Stock Option shall be not
less than the Fair Market  Value of the stock  subject to the Option on the date
the Option is granted.

     Consideration.  The purchase price of stock acquired  pursuant to an Option
shall be paid, to the extent  permitted by applicable  statutes and regulations,
either  (i) in  cash  at the  time  the  Option  is  exercised,  or  (ii) at the
discretion  of the  Board  or the  Committee,  at the  time of the  grant of the
Option, (A) by delivery to the Company of other common stock of the Company, (B)
according to a deferred payment  arrangement,  except that payment of the common
stock's "par value" (as defined in the Delaware  General  Corporation Law) shall
not be made by  deferred  payment  or other  arrangement,  (which  may  include,
without limiting the generality of the foregoing,  the use of other common stock
of the  Company)  with the  person to whom the  Option is granted or to whom the
Option is transferred  pursuant to subsection  6(d), or (C) in any other form of
legal consideration that may be acceptable to the Board.

     In  the  case  of any  deferred  payment  arrangement,  interest  shall  be
compounded  at least  annually  and  shall be  charged  at the  minimum  rate of
interest  necessary to avoid the  treatment as  interest,  under any  applicable
provisions of the Code, of any amounts other than amounts  stated to be interest
under the deferred payment arrangement.

     Transferability.  An Option shall not be transferable  except by will or by
the laws of  descent  and  distribution  (and  shall be  exercisable  during the
lifetime of the person to whom the Option is granted only by such person) unless
the applicable Option Agreement  expressly  provides for other  transferability.
Notwithstanding the foregoing,  the person to whom the Option is granted may, by
delivering written notice to the Company, in a form satisfactory to the Company,
designate a third party who,  in the event of the death of the  Optionee,  shall
thereafter be entitled to exercise the Option.

     Vesting.  The total number of shares of stock subject to an Option may, but
need not,  be allotted in  periodic  installments  (which may,  but need not, be
equal).  The Option  Agreement may provide that from time to time during each of
such  installment  periods,  the  Option may become  exercisable  ("vest")  with
respect  to some  or all of the  shares  allotted  to  that  period,  and may be
exercised  with  respect to some or all of the shares  allotted  to such  period
and/or any prior period as to which the Option  became  vested but was not fully
exercised.  The Option may be subject to such other terms and  conditions on the
time or times when it may be  exercised  (which may be based on  performance  or
other  criteria)  as the  Board may deem  appropriate.  The  provisions  of this
subsection  6(e) are  subject to any Option  provisions  governing  the  minimum
number of shares as to which an Option may be exercised.

     Termination of Employment or Relationship as a Consultant.  In the event an
Optionee's Continuous Status as an Employee or Consultant terminates (other than
upon the Optionee's  death or disability),  the Optionee may exercise his or her
Option (to the extent that the  Optionee  was  entitled to exercise it as of the
date of  termination)  but only within such period of time ending on the earlier
of (i) the date  three  (3)  months  after  the  termination  of the  Optionee's
Continuous Status as an Employee or Consultant (or such longer or shorter period
specified in the Option  Agreement),  or (ii) the  expiration of the term of the
Option as set forth in the Option Agreement. If, at the date of termination, the
Optionee  is not  entitled  to  exercise  his or her entire  Option,  the shares
covered by the  unexercisable  portion of the Option  shall  revert to and again
become  available  for  issuance  under the Plan.  If,  after  termination,  the
Optionee  does not exercise his or her Option  within the time  specified in the
Option  Agreement,  the Option shall  terminate,  and the shares covered by such
Option shall revert to and again become available for issuance under the Plan.

     An Optionee's Option Agreement may also provide that if the exercise of the
Option  following the  termination  of the  Optionee's  Continuous  Status as an
Employee or  Consultant  (other than upon the  Optionee's  death or  disability)
would result in liability  under  Section  16(b) of the Exchange  Act,  then the
Option shall  terminate on the earlier of (i) the  expiration of the term of the
Option set forth in the Option Agreement, or (ii) the tenth (10th) day after the
last date on which such exercise  would result in such  liability  under Section
16(b) of the Exchange  Act.  Finally,  an Optionee's  Option  Agreement may also
provide  that if the exercise of the Option  following  the  termination  of the
Optionee's  Continuous  Status as an Employee or Consultant (other than upon the
Optionee's  death or disability)  would be prohibited at any time solely because
the issuance of shares would  violate the  registration  requirements  under the
Act, then the Option shall terminate on the earlier of (i) the expiration of the
term of the Option set forth in the first paragraph of this subsection  6(f), or
(ii) the expiration of a period of thirty (30) days after the termination of the
Optionee's  Continuous  Status as an Employee  or  Consultant  during  which the
exercise  of  the  Option  would  not  be  in  violation  of  such  registration
requirements.

     Disability of Optionee.  In the event an Optionee's Continuous Status as an
Employee or Consultant terminates as a result of the Optionee's disability,  the
Optionee  may  exercise  his or her Option (to the extent that the  Optionee was
entitled  to exercise  it as of the date of  termination),  but only within such
period  of time  ending  on the  earlier  of (i) the  date  twelve  (12)  months
following such  termination  (or such longer or shorter period  specified in the
Option Agreement), or (ii) the expiration of the term of the Option as set forth
in the Option  Agreement.  If, at the date of  termination,  the Optionee is not
entitled  to  exercise  his or her  entire  Option,  the  shares  covered by the
unexercisable  portion of the Option shall revert to and again become  available
for issuance  under the Plan.  If,  after  termination,  the  Optionee  does not
exercise his or her Option within the time  specified  herein,  the Option shall
terminate,  and the shares  covered  by such  Option  shall  revert to and again
become available for issuance under the Plan.

     Death of  Optionee.  In the event of the death of an  Optionee  during,  or
within a period  specified in the Option Agreement after the termination of, the
Optionee's  Continuous  Status as an Employee or  Consultant,  the Option may be
exercised  (to the extent the Optionee was entitled to exercise the Option as of
the date of death) by the Optionee's  estate, by a person who acquired the right
to  exercise  the Option by bequest or  inheritance,  but only within the period
ending on the earlier of (i) the date eighteen (18) months following the date of
death (or such longer or shorter period specified in the Option  Agreement),  or
(ii)  the  expiration  of the term of such  Option  as set  forth in the  Option
Agreement.  If, at the time of death,  the Optionee was not entitled to exercise
his or her entire Option, the shares covered by the unexercisable portion of the
Option shall revert to and again become  available for issuance  under the Plan.
If, after death, the Option is not exercised  within the time specified  herein,
the Option shall  terminate,  and the shares covered by such Option shall revert
to and again become available for issuance under the Plan.

TERMS OF STOCK BONUSES AND PURCHASES OF RESTRICTED STOCK.

     Each stock bonus or restricted  stock purchase  agreement  shall be in such
form and shall  contain such terms and  conditions as the Board or the Committee
shall deem  appropriate.  The terms and  conditions of stock bonus or restricted
stock  purchase  agreements  may  change  from  time to time,  and the terms and
conditions of separate agreements need not be identical, but each stock bonus or
restricted  stock purchase  agreement shall include  (through  incorporation  of
provisions  hereof by reference in the agreement or otherwise)  the substance of
each of the following provisions as appropriate:

     Purchase  Price.  The purchase price under each  restricted  stock purchase
agreement  shall be such amount as the Board or Committee  shall  determine  and
designate in such  agreement,  but in no event shall the purchase  price be less
than  the  stock's   Fair  Market   Value  on  the  date  such  award  is  made.
Notwithstanding  the  foregoing,  the Board or the Committee may determine  that
eligible participants in the Plan may be awarded stock pursuant to a stock bonus
agreement in consideration for past services actually rendered to the Company or
for its benefit.

     Transferability. No rights under a stock bonus or restricted stock purchase
agreement  shall  be  transferable  except  by will or the laws of  descent  and
distribution, unless the applicable Stock Award Agreement expressly provides for
other transferability.

     Consideration.  The purchase  price of stock  acquired  pursuant to a stock
purchase  agreement  shall be paid either:  (i) in cash at the time of purchase;
(ii) at the  discretion of the Board or the  Committee,  according to a deferred
payment or other  arrangement,  except that  payment of the common  stock's "par
value" (as defined in the Delaware General Corporation Law) shall not be made by
deferred payment or other arrangement,  (which may include, without limiting the
generality of the foregoing,  the use of other common stock of the Company) with
the  person  to whom  the  stock is sold;  or (iii) in any  other  form of legal
consideration  that  may be  acceptable  to the  Board or the  Committee  in its
discretion.  Notwithstanding the foregoing,  the Board or the Committee to which
administration  of the Plan has been  delegated  may award  stock  pursuant to a
stock bonus agreement in consideration  for past services  actually  rendered to
the  Company or for its  benefit.  In any  event,  the  purchase  price of stock
acquired  pursuant  to  either  a stock  purchase  agreement  or a  stock  bonus
agreement shall equal or exceed the par value of the stock acquired  pursuant to
such agreement.

     Vesting.  Shares of stock sold or awarded under the Plan may, but need not,
be subject to a repurchase  option in favor of the Company in accordance  with a
vesting schedule to be determined by the Board or the Committee.

     Termination of Employment or Relationship  as a Consultant.  In the event a
Participant's  Continuous  Status as an Employee or Consultant  terminates,  the
Company  may  repurchase  or  otherwise  reacquire,  subject to the  limitations
described  in  subsection  7(d),  any or all of the shares of stock held by that
person  which have not vested as of the date of  termination  under the terms of
the stock bonus or restricted stock purchase  agreement  between the Company and
such person.

COVENANTS OF THE COMPANY.

     During the terms of the Stock Awards,  the Company shall keep  available at
all times the number of shares of stock required to satisfy such Stock Awards.

     The Company shall seek to obtain from each regulatory  commission or agency
having jurisdiction over the Plan such authority as may be required to issue and
sell shares of stock upon exercise of the Stock Award;  provided,  however, that
this undertaking  shall not require the Company to register under the Securities
Act of 1933, as amended (the "Securities  Act") either the Plan, any Stock Award
or any stock  issued or issuable  pursuant to any such Stock  Award.  If,  after
reasonable  efforts,  the Company is unable to obtain  from any such  regulatory
commission or agency the authority which counsel for the Company deems necessary
for the lawful  issuance and sale of stock under the Plan,  the Company shall be
relieved from any liability for failure to issue and sell stock upon exercise of
such Stock Awards unless and until such authority is obtained.

USE OF PROCEEDS FROM STOCK.

     Proceeds from the sale of stock  pursuant to Stock Awards shall  constitute
general funds of the Company.

MISCELLANEOUS.

     The  Board  shall  have the power to  accelerate  the time at which a Stock
Award may first be  exercised or the time during which a Stock Award or any part
thereof  will vest  pursuant to  subsection  6(e) or 7(d),  notwithstanding  the
provisions  in the  Stock  Award  stating  the  time at  which  it may  first be
exercised or the time during which it will vest.

     Neither an Employee or  Consultant  nor any person to whom a Stock Award is
transferred  under  subsection 6(d) or 7(b) shall be deemed to be the holder of,
or to have any of the rights of a holder with respect to, any shares  subject to
such Stock Award unless and until such person has satisfied all requirements for
exercise of the Stock Award pursuant to its terms.

     Nothing  in the Plan or any  instrument  executed  or Stock  Award  granted
pursuant  thereto shall confer upon any Employee,  Consultant or other holder of
Stock Awards any right to continue in the employ of the Company or any Affiliate
(or to continue acting as a Consultant) or shall affect the right of the Company
or any  Affiliate to terminate  the  employment  of any Employee with or without
cause or to terminate the relationship of any Consultant subject to the terms of
that  Consultant's  agreement  with the  Company  or  Affiliate  to  which  such
Consultant is providing services.

     Securities  Law  Compliance.  The  Company may require any person to whom a
Stock  Award is  granted,  or any  person to whom a Stock  Award is  transferred
pursuant to  subsection  6(d) or 7(b), as a condition of exercising or acquiring
stock under any Stock Award, (i) to give written assurances  satisfactory to the
Company as to such person's  knowledge and  experience in financial and business
matters and/or to employ a purchaser  representative  reasonably satisfactory to
the Company who is  knowledgeable  and  experienced  in  financial  and business
matters, and that he or she is capable of evaluating, alone or together with the
purchaser  representative,  the merits and risks of exercising  the Stock Award;
and (ii) to give written  assurances  satisfactory  to the Company  stating that
such person is acquiring  the stock subject to the Stock Award for such person's
own  account  and not  with  any  present  intention  of  selling  or  otherwise
distributing  the stock.  The foregoing  requirements,  and any assurances given
pursuant to such  requirements,  shall be inoperative if (i) the issuance of the
shares upon the exercise or  acquisition of stock under the Stock Award has been
registered  under a then currently  effective  registration  statement under the
Securities Act, or (ii) as to any particular  requirement,  a  determination  is
made by counsel for the  Company  that such  requirement  need not be met in the
circumstances under the then applicable securities laws. The Company may require
the holder of the Stock  Award to provide  such other  representations,  written
assurances  or  information  which the Company  shall  determine  is  necessary,
desirable or appropriate to comply with applicable  securities and other laws as
a condition of granting a Stock Award to such person or permitting the holder of
the Stock Award to exercise  the Stock Award.  The Company  may,  upon advice of
counsel to the Company,  place  legends on stock  certificates  issued under the
Plan as such  counsel  deems  necessary or  appropriate  in order to comply with
applicable securities laws,  including,  but not limited to, legends restricting
the transfer of the stock.

     Withholding.  To  the  extent  provided  by  the  terms  of a  Stock  Award
Agreement,  the person to whom a Stock Award is granted may satisfy any federal,
state  or  local  tax  withholding   obligation  relating  to  the  exercise  or
acquisition  of stock under a Stock Award by any of the following  means or by a
combination of such means:  (i) tendering a cash payment;  (ii)  authorizing the
Company  to  withhold  shares  from the  shares of the  common  stock  otherwise
issuable to the  participant as a result of the exercise or acquisition of stock
under the Stock Award; or (iii) delivering to the Company owned and unencumbered
shares of the common stock of the Company.

ADJUSTMENTS UPON CHANGES IN STOCK.

     If any change is made in the stock  subject to the Plan,  or subject to any
Stock  Award,  without the  receipt of  consideration  by the  Company  (through
merger, consolidation, reorganization, recapitalization,  reincorporation, stock
dividend,  dividend  in  property  other than  cash,  stock  split,  liquidating
dividend,  combination  of  shares,  exchange  of  shares,  change in  corporate
structure or other transaction not involving the receipt of consideration by the
Company), the Plan will be appropriately adjusted in the type(s) and the maximum
number of securities  subject to the Plan pursuant to subsection  4(a),  and the
outstanding  Stock  Awards  will be  appropriately  adjusted  in the type(s) and
number of securities  and price per share of stock  subject to such  outstanding
Stock Awards. Such adjustments shall be made by the Board or the Committee,  the
determination of which shall be final,  binding and conclusive.  (The conversion
of any  convertible  securities  of  the  Company  shall  not  be  treated  as a
"transaction not involving the receipt of consideration by the Company.")

     In the event of: (i) a dissolution or  liquidation  of the Company;  (ii) a
merger or consolidation  in which the Company is not the surviving  corporation;
(iii) a reverse merger in which the Company is the surviving corporation but the
shares of the  Company's  common stock  outstanding  immediately  preceding  the
merger are converted by virtue of the merger into other property, whether in the
form of securities,  cash or otherwise; or (iv) any other capital reorganization
in which more than fifty percent (50%) of the shares of the Company  entitled to
vote are exchanged,  then, at the sole discretion of the Board and to the extent
permitted by  applicable  law: (A) any  surviving  corporation  shall assume any
Stock Awards outstanding under the Plan or shall substitute similar Stock Awards
for those  outstanding  under the Plan,  (B) such Stock Awards shall continue in
full force and effect, or (C) any outstanding unexercised rights under any Stock
Awards  shall be  terminated  if not  exercised  prior to such event,  provided,
however,  that with  respect to Stock  Awards  then held by  persons  performing
services  for the  Company or an  Affiliate,  the time  during  which such Stock
Awards  become  vested or may be exercised  shall be  accelerated  prior to such
termination.

     In the event a change in control  (as  hereinafter  defined)  occurs at the
Company  and,  within  one (1) year of such  change in  control,  an  Optionee's
employment  with the Company and its  Affiliates  is  terminated  other than for
cause (as hereinafter  defined) Options held by such terminated  Employee may be
exercised  in full  following  such  termination  without  regard to the vesting
limitations to which such Options are otherwise subject. For the purposes of the
foregoing,  a "change  in  control"  shall have  occurred  if (i) any person (as
defined in Section 13 of the Exchange Act) acquires shares,  other than directly
from the  Company,  and thereby  becomes  the owner of more than thirty  percent
(30%) of the Company's outstanding shares (on a fully diluted basis) or (ii) the
Company  enters  into a merger  (other than one in  connection  with a voluntary
change of  corporate  domicile  or similar  reorganization  or  recapitalization
transaction) in which the  stockholders of the Company  (determined  immediately
prior to the merger) do not own at least fifty percent (50%) of the  outstanding
shares of the surviving entity after the merger.  For purposes of the foregoing,
a  termination  shall be deemed to have been made for  "cause"  in the event the
Optionee's  employment is terminated for any of the following  reasons:  (A) the
Optionee's  continued  failure to  substantially  perform  his  duties  with the
Company or its Affiliates,  (B) the engaging by the Optionee in gross misconduct
materially and  demonstrably  injurious to the Company,  its Affiliates or their
Employees,  or (C)  illicit  drug  use  or  habitual  alcohol  use,  or (D)  the
commission by the Optionee of any felony.

AMENDMENT OF THE PLAN AND STOCK AWARDS.

     The Board at any time, and from time to time, may amend the Plan.

     The Board may, in its sole discretion, submit the Plan and/or any amendment
to the Plan for stockholder approval.

     It is  expressly  contemplated  that the  Board  may  amend the Plan in any
respect the Board deems  necessary or advisable to provide  those  eligible with
the maximum benefits provided or to be provided under the provisions of the Code
and the regulations promulgated thereunder.

     Rights and  obligations  under any Stock Award granted before  amendment of
the Plan  shall not be  impaired  by any  amendment  of the Plan  unless (i) the
Company  requests  the consent of the person to whom the Stock Award was granted
and (ii) such person consents in writing.

     The  Board at any time,  and from time to time,  may amend the terms of any
one or more Stock  Award;  provided,  however,  that the rights and  obligations
under any Stock Award shall not be impaired by any such amendment unless (i) the
Company  requests  the consent of the person to whom the Stock Award was granted
and (ii) such person consents in writing.

TERMINATION OR SUSPENSION OF THE PLAN.

     The Board may  suspend or  terminate  the Plan at any time.  Unless  sooner
terminated, the Plan shall terminate on November 10, 2006, which shall be within
ten (10) years from the date the Plan is adopted by the Board.  No Stock  Awards
may be  granted  under  the  Plan  while  the Plan is  suspended  or after it is
terminated.

     Rights and  obligations  under any Stock Award granted while the Plan is in
effect shall not be impaired by suspension or  termination  of the Plan,  except
with the written consent of the person to whom the Stock Award was granted.

 EFFECTIVE DATE OF PLAN.

     The Plan shall become effective on November 11, 1996.



Notice of Grant of Stock Options             Scios Inc.
and Option Agreement                         ID:  95-3701481
                              2450 Bayshore Parkway
                             Mountain View, CA 94043


Name                                         Option Number:
Address                                      Plan:
City, State, Zip                             ID:

- -------------------------------------------------------------------------------

Effective ____________, you have been granted a(n) Non-Qualified Stock Option to
buy shares of Scios Inc. (the Company) stock at $_________ per share.  The total
option price of the shares granted is $ .

Shares in each period will become fully vested on the date shown.

   Shares         Vest Type             Full Vest             Expiration









- -------------------------------------------------------------------------------

By your signature and the Company's  signature  below, you and the Company agree
that these options are granted under and governed by the terms and conditions of
the  Company's  Stock  Option Plan as amended and the Option  Agreement,  all of
which are attached and made a part of this document.

- -------------------------------------------------------------------------------


- --------------------------                       ----------------------------
Scios Inc.                                       Date


- --------------------------                       -----------------------------
Optionee                                         Date

<PAGE>


                   NON-STATUTORY STOCK OPTION AGREEMENT UNDER
                       1996 NON-OFFICER STOCK OPTION PLAN
                                  OF SCIOS INC.

The terms of this non-statutory  (non-qualified)  option are as set forth in the
preceding page and below:

         1. Acceleration of Vesting. Notwithstanding the vesting schedule on the
preceding cover sheet, in the event a change in control (as hereinafter defined)
occurs at the  Company  after the date  hereof,  and within one (1) year of such
change in control your employment with the Company or an Affiliate (as such term
is  defined  in the Plan) is  terminated  other  than for cause (as  hereinafter
defined),  this option may be  exercised  in full  following  such  termination,
without regard to the vesting  limitations set forth above.  For the purposes of
the  foregoing,  a "change in control" shall have occurred if (i) any person (as
defined  in Section  13 of the  Securities  Exchange  Act of 1934,  as  amended)
acquires shares,  other than directly from the Company,  and thereby becomes the
owner of more than 30% of the Company's  outstanding  shares (on a fully diluted
basis) or (ii) the Company  enters into a merger  (other than one in  connection
with a  voluntary  change of  corporate  domicile or similar  reorganization  or
recapitalization   transaction)  in  which  the   stockholders  of  the  Company
(determined  immediately  prior to the  merger)  do not own at least  50% of the
outstanding shares of the surviving entity after the merger. For the purposes of
the  foregoing,  a termination  shall be deemed to have been made for "cause" in
the  event  you  are  terminated  for any of the  following  reasons:  (A)  your
continued failure to substantially perform your duties with the Company, (B) the
engaging by you in gross misconduct materially and demonstrably injurious to the
Company or its employees,  (C) illicit drug use or habitual  alcohol use, or (D)
the commission by you of any felony.

         2. Payment of Exercise  Price.  Payment of the exercise price per share
is due in full in cash (including  check) when the option exercise price for the
vested  shares  being  purchased  is five  hundred  dollars  ($500.00)  or less;
provided, however, when the exercise price for the vested shares being purchased
exceeds five  hundred  dollars  ($500.00),  you may elect to make payment of the
exercise price under one of the following alternatives:

         (i)  Payment  of the  exercise  price in cash (or check) at the time or
exercise (which shall include payment pursuant to a "cashless"  exercise program
developed  under  Regulation T as promulgated by the Federal Reserve Board which
results in the receipt of cash (or check) by the Company  prior to the  issuance
of common stock to you);

         (ii) (A) Payment of not less than twenty percent (20%) of the aggregate
exercise  price  due in cash at the time of  exercise  and the  balance  by your
promissory note under which not less than an additional  twenty percent (20%) of
said exercise  price,  plus  interest at the rate  determined in part (B) below,
shall be due on each of the next four (4) anniversaries of the time of exercise,
with full  payment of the  promissory  note for the  remainder  of the  exercise
price, plus unpaid interest, due four (4) years from date of exercise or, at the
Company's  election,  upon termination of your employment with the Company or an
Affiliate;  provided that as a part of your written  notice of exercise you give
notice of the election of this deferred payment  arrangement,  and to secure the
payment of the deferred exercise price to the Company hereunder,  if the Company
so  requests,  you tender,  in forms  satisfactory  to the  Company,  a note,  a
security  agreement  covering the purchased  shares, or such other or additional
documentation as the Company may request;

                  (B) Interest  shall be charged at the minimum rate of interest
necessary  to avoid the  recharacterization  as interest,  under any  applicable
provisions of the Code,  of any portion of any deferred  payment of the exercise
price hereunder; or

         (iii)  Provided  that if at the time of exercise the  Company's  common
stock is  publicly  traded  and quoted  regularly  in the Wall  Street  Journal,
payment by delivery of already-owned  shares of common stock owned by you for at
least six (6) months and owned free and clear of any liens, claims, encumbrances
or security  interests,  which  common  stock shall be valued (i) if listed on a
national  securities  exchange or quoted on the Nasdaq National  Market,  at the
closing price on the trading day  immediately  preceding the date of exercise or
(ii) otherwise at the average of the closing bid and ask quotations published in
the Wall Street  Journal for the trading day  immediately  preceding the date of
exercise; or

         (iv)     Payment by a combination of  the methods of payment  specified
in  subparagraphs  2(i)  through 2(iii) above.

         3. Adjustment and Minimum Exercise.  In the event there occurs a change
in the  structure of the Company or in its  outstanding  stock which affects the
rights and  participation  to which you would be entitled as of the date of such
event had you exercised  this option prior to such date,  there shall be made an
adjustment  in the number of shares and the exercise  price of this option as of
the date of such event which shall result in your receiving proportionate rights
and  participation  after the  occurrence of such event.  The minimum  number of
shares with respect to which this option may be exercised at any one time is one
hundred (100),  unless this option is then exercisable for less than one hundred
(100) shares,  in which case, the number of shares then exercisable shall be the
minimum number of shares.

         4.  Securities  Act of 1933.  Notwithstanding  anything to the contrary
contained  herein,  this option may not be exercised  unless the shares issuable
upon exercise of this option are then  registered  under the  Securities  Act of
1933, as amended (the "Act"), or, if such shares are not then so registered, the
Company has determined  that such exercise and issuance would be exempt from the
registration requirements of the Act.

         5. Term.  THE TERM OF THIS  OPTION  COMMENCES  ON THE DATE  HEREOF AND,
UNLESS SOONER  TERMINATED  AS SET FORTH BELOW OR IN THE PLAN,  TERMINATES ON THE
DATE EXACTLY TEN (10) YEARS MINUS ONE (1) DAY FROM THE DATE OF THIS OPTION. This
option shall terminate prior to the expiration of its term as follows: three (3)
months after the termination of your employment with the Company or an Affiliate
for any reason or for no reason unless (a) such termination of employment is due
to your permanent and total disability  (within the meaning of Section 422(c)(6)
of the Code),  in which case the option  shall  terminate  on the earlier of the
termination  date set forth  above or one  twelve  (12)  months  following  such
termination of employment;  or (b) such termination of employment is due to your
death,  in  which  case  the  option  shall  terminate  on  the  earlier  of the
termination  date set forth  above or  eighteen  (18)  months  after your death.
However,  in any and all circumstances,  this option may be exercised  following
termination  of employment  with the Company only as to that number of shares as
to which it was  exercisable on the date of  termination of employment  with the
Company.

         6.  Manner of  Exercise.  This option may be  exercised,  to the extent
specified  above, by delivering a notice of exercise  together with the exercise
price to the  Secretary of the  Company,  or to such other person as the Company
may designate,  during regular  business  hours,  together with such  additional
documents as the Company may then require pursuant to subparagraph  10(d) of the
Plan.

         7. Non-Transferable. This option is not transferable, except by will or
by the laws of descent and  distribution,  and is  exercisable  during your life
only by you.  Notwithstanding  the  foregoing,  you may, be  delivering  written
notice to the Company in a form  satisfactory to the Company,  designate a third
party who, in the event of your death,  shall thereafter be entitled to exercise
the option.

         8.  Not an  Employment  Contract.  This  option  is  not an  employment
contract  and  nothing in this  option  shall be deemed to modify  your  at-will
employment  relationship  with  Scios  to  create  in  any  way  whatsoever  any
obligation  on your part to continue in the employ of the Company (or service as
a Consultant),  or of the Company to continue your  employment  with the Company
(or service as a Consultant).

         9. Notices.  Any notices  provided for in this option or the Plan shall
be given in writing and shall be deemed  effectively  given upon  receipt or, in
the case of notices delivered by the Company to you, five (5) days after deposit
in the United  States  mail,  postage  prepaid,  addressed to you at the address
specified  above or at such other address as you hereafter  designate by written
notice to the Company.

         10. Plan Terms.  This  option is subject to all the  provisions  of the
Plan and its provisions are hereby made a part of this option, including without
limitation  the  provisions  of  paragraph  6 of the  Plan  relating  to  option
provisions, and is further subject to all interpretations, amendments, rules and
regulations  which may from time to time be promulgated and adopted  pursuant to
the Plan. In the event of any conflict between the provisions of this option and
those of the Plan, the provisions of the Plan shall control.




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