SCIOS INC
DEF 14A, 1998-03-27
DRUGS, PROPRIETARIES & DRUGGISTS' SUNDRIES
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                         SCHEDULE 14A INFORMATION


                  Proxy Statement Pursuant to Section 14(a) of
            the Securities Exchange Act of 1934 (Amendment No.    )

    Filed by the Registrant /X/
    Filed by a Party other than the Registrant / /

    Check the appropriate box:
    / /    Preliminary Proxy Statement
    / /    Confidential, for Use of the Commission Only (as permitted by Rule
             14a-6(e)(2))
    /X/    Definitive Proxy Statement
    / /    Definitive Additional Materials
    / /    Soliciting  Material  Pursuant  to  Section  240.14a-11(c)  or
               Section 240.14a-12

                          SCIOS INC
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

/X/  No fee required.
/ /  Fee  computed  on   table  below   per  Exchange   Act  Rules   14a-6(i)(1)
     and 0-11.
     1) Title of each class of securities to which transaction applies:
        ------------------------------------------------------------------------
     2) Aggregate number of securities to which transaction applies:
        ------------------------------------------------------------------------
     3) Per unit  price  or  other  underlying  value  of  transaction  computed
        pursuant  to  Exchange  Act Rule 0-11 (Set forth the amount on which the
        filing fee is calculated and state how it was determined):
        ------------------------------------------------------------------------
     4) Proposed maximum aggregate value of transaction:
        ------------------------------------------------------------------------
     5) Total fee paid:
        ------------------------------------------------------------------------
/ /  Fee paid previously with preliminary materials.
/    / Check box if any part of the fee is offset as provided  by  Exchange  Act
     Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
     paid  previously.  Identify the previous filing by  registration  statement
     number, or the Form or Schedule and the date of its filing.
     1) Amount Previously Paid:
        ------------------------------------------------------------------------
     2) Form, Schedule or Registration Statement No.:
        ------------------------------------------------------------------------
     3) Filing Party:
        ------------------------------------------------------------------------
     4) Date Filed:
        ------------------------------------------------------------------------

<PAGE>
                                     [LOGO]



                                   Scios Inc.
                              2450 Bayshore Parkway
                         Mountain View, California 94043

                                   ----------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                              Tuesday, May 12, 1998
                                   10:00 a.m.
                                   ----------

To the Stockholders:

         NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of Scios
Inc., a Delaware  corporation  (the  "Company"),  will be held at the  Company's
principal executive offices,  2450 Bayshore Parkway,  Mountain View,  California
94043,  at 10:00 a.m. on Tuesday,  May 12,  1998,  to consider  and act upon the
following matters:

         (1)      To elect directors of the Company.

         (2)      To approve amendments to the Company's 1992 Equity Incentive
                  Plan.

         (3)      To ratify the selection of Coopers & Lybrand L.L.P. as the 
                  Company's independent auditors for fiscal 1998.

         (4)      To act upon such other  matters that may properly come before
                  the meeting or any adjournment or postponement of the meeting.

         Only  stockholders of record at the close of business on March 16, 1998
will be entitled to notice of and to vote at this meeting and any adjournment or
postponement thereof.

                                             By Order of the Board of Directors

                                             JOHN H. NEWMAN
                                             Secretary


Mountain View, California
March 31, 1998

YOUR VOTE IS IMPORTANT.  WHETHER OR NOT YOU EXPECT TO ATTEND THIS MEETING, 
PLEASE MARK, DATE AND SIGN THE ENCLOSED PROXY AND MAIL IT PROMPTLY IN THE 
ENCLOSED ENVELOPE.  NO POSTAGE IS REQUIRED IF MAILED IN THE UNITED STATES.


<PAGE>
                                                   

                                   Scios Inc.
                              2450 Bayshore Parkway
                         Mountain View, California 94043
                                   ----------

                                 Proxy Statement
                         Annual Meeting of Stockholders
                                  May 12, 1998


General

         This  Proxy  Statement is solicited on behalf of the Board of Directors
of Scios Inc., a Delaware corporation (the "Company" or "Scios"), for use at its
Annual Meeting of  Stockholders  to be held at the Company's principal executive
offices, 2450 Bayshore Parkway, Mountain  View,  California 94043, at 10:00 a.m.
on  Tuesday, May  12,  1998,  and  at  any  adjournment or postponement of that 
meeting.  The approximate mailing date for this Proxy Statement and the enclosed
proxy is March 31, 1998.

         The  Board  of  Directors  has fixed the close of business on March 16,
1998 as the record date for the determination  of  stockholders entitled to vote
at the Annual Meeting.  At that time,  there  were  37,655,474  shares of Common
Stock issued and outstanding (net of Treasury Shares).

Voting

         Each share of Common Stock issued and outstanding on the record date is
entitled to one vote. The proxy holders will vote all proxies in accordance with
the  instructions  contained  in  the  proxy and, if no choice is specified, the
proxy holders will vote in favor of the proposals to elect directors, to approve
the  amendment  of  the  Company's 1992  Equity Incentive Plan and to ratify the
selection  of  auditors.  An  automated  system  administered  by  the Company's
transfer agent tabulates the votes. The presence at the Annual Meeting in person
or by proxy of a majority of the shares outstanding as of the record  date  will
constitute a quorum.  For quorum purposes, abstentions and broker non-votes  are
each  included  in the determination of the number of shares present and voting.
Each matter is tabulated  separately.  Abstentions are counted in tabulations of
the votes cast on proposals presented  to stockholders, whereas broker non-votes
are  not  counted  for  any  purpose  in determining whether a proposal has been
approved.

Revocability of Proxies

         Any person giving a proxy in the form accompanying this Proxy Statement
has the power to revoke it at any time before its exercise. It may be revoked by
filing with the Secretary of the Company  an  instrument of revocation or a duly
executed proxy bearing a later date. It also may be revoked by attendance at the
meeting and election  to vote in person.  Attendance  at  the  meeting  will not
itself revoke a proxy.
<PAGE>

Solicitation

         The  Company  will bear  the  entire  cost  of  preparing, assembling, 
printing  and  mailing  this  Proxy  Statement,  the  accompanying proxy and any
additional  material  which  may  be  furnished  to stockholders by the Company.
Copies  of  solicitation  material will be furnished without charge to brokerage
houses, fiduciaries and custodians to forward to beneficial owners of stock held
in their names. The solicitation of proxies will be made by the use of the mails
and   through  direct  communication   with   certain  stockholders  or  their 
representatives  by  officers,  directors and employees of the Company, who will
receive  no  additional  compensation  therefor.   In  addition, the Company may
determine  to  engage  Corporate  Investor Communications, Inc. or another proxy
solicitor  to  solicit  proxies  and,  if  it  does so, the Company will pay the
standard fee for these services, which is estimated to be approximately $3,000.


                                   PROPOSAL 1
                              ELECTION OF DIRECTORS

         A Board of nine (9)  Directors  will be elected at the Annual  Meeting.
The term of office of each person  elected as a Director will continue until the
next Annual  Meeting or until a successor  has been  elected.  Unless  otherwise
instructed,  the proxy  holders  will vote the proxies  received by them for the
nine nominees of the Board of Directors  named below,  all of whom are presently
Directors of the Company.  The candidates  receiving a plurality of the votes of
the shares  present in person or by proxy at the  meeting  and  entitled to vote
will be  elected.  Each person  nominated  for  election  has agreed to serve if
elected, and management has no reason to believe that any nominee will be unable
to serve.  If any nominee  for any reason is unable or  declines  to serve,  the
proxies will be voted for any substitute  nominee who shall be designated by the
present  Board of  Directors  to fill the  vacancy.  Stockholders  who desire to
nominate  persons for election to the Board must comply with the advance  notice
procedures specified in the Company's Bylaws.

         The   following  is  information  regarding  the  nominees,  including 
information furnished by them as to their principal occupation for the preceding
five-year period, certain directorships and their ages as of March 16, 1998.
                                                                        
                                                            Director
                  Name                   Age                 Since

         Samuel H. Armacost              59                   1995
         Richard L. Casey                51                   1987
         Myron Du Bain                   74                   1989
         Donald B. Rice, Ph.D.           58                   1997
         Charles A. Sanders, M.D.        66                   1997
         Robert W. Schrier, M.D.         62                   1988
         Solomon H. Snyder, M.D.         59                   1992
         Burton E. Sobel, M.D.           60                   1996
         Eugene L. Step                  69                   1993

         Mr. Armacost was elected  to the Company's Board of Directors in August
1995.  Since September 1990, Mr. Armacost has been a Managing Director of Weiss,
Peck & Greer, L.L.C., an  investment firm.  Previously, he  served as  Managing 
Director of Merrill Lynch Capital  Markets  from  1987  to August 1990, and was 
President, Director and Chief Executive Officer of BankAmerica Corporation from 
1981  to  1986.  Mr.  Armacost  is  also  a  member of the Board of Directors of
Chevron  Corporation,  Exponent, Inc. and  SRI  International.  In addition, Mr.
Armacost is on the board of the  James  Irvine Foundation and the Advisory Board
of the California Academy of Sciences, and he is a member of The Business 
Council.
<PAGE>
         Mr.  Casey  is  Chairman  of  the  Board, President and Chief Executive
Officer  of  Scios  Inc.  He  joined  Scios in December 1987 and has served as a
Director since that time. From early 1985  to 1987, he was with ALZA Corporation
as Executive Vice President and President of ALZA Pharmaceuticals.  From 1976 to
1985 he worked for Syntex Corporation, in various  positions  including Director
of Marketing Research, Director of Sales, Vice President and  General Manager of
Syntex  Medical Diagnostics.  Mr. Casey began his career in pharmaceuticals as a
Sales  Representative  for Eli Lilly and Company.  From 1968 to 1970,  Mr. Casey
served in the U.S. Peace Corps  in  Ethiopia.  Mr. Casey serves on the boards of
Guilford  Pharmaceuticals  Inc., an  affiliated  publicly-held development-stage
neuroscience  company  located in Baltimore,  Maryland; VIVUS, Inc., a publicly-
held medical devices company  located in Mountain View, California; and Karo Bio
AB,  an  affiliated  privately-held  biotechnology company located in Stockholm,
Sweden.

         Mr.  Du Bain  was  elected  a  Director of  Scios in June 1989.  He was
Chairman  of  the  Board  of  Directors  of  SRI  International  of  Menlo Park,
California, a contract research and consulting company, from December 1985 until
he  retired  in  December  1989.  From  1983 to 1985, he was President and Chief
Executive   Officer  of  Amfac,  Inc.,  a   diversified  distribution  company.
Previously, Mr. Du Bain was Chairman, President and Chief Executive  Officer  of
Fireman's  Fund  Corporation  and Vice Chairman of the Board of American Express
Company.  He is a member of the Board of Directors of SRI International.  He was
formerly a member of the Board  of  Directors  of Wells Fargo & Co., Pacific Gas
and  Electric  Co.,  Pacific  Telesis  Group, First Interstate Bancorp, Potlatch
Corporation,  Carter  Hawley  Hale  Stores  Inc., The  Chronicle Publishing Co.,
Transamerica Corporation and several other corporations. He was also Chairman of
the  Board  of  Directors  of the James Irvine Foundation and served on numerous
boards of non-profit organizations.

         Dr. Rice  was elected a Director of Scios in August 1997.  Dr. Rice has
been the President and Chief Executive Officer  of  UroGenesys, Inc. since 1996.
Previously, he served as President and Chief Operating Officer of Teledyne, Inc.
from  1993  to  1996, as  Secretary  of  the Air Force in the U.S. Department of
Defense  from  1989 to 1993, and as President and Chief Executive Officer of The
RAND  Corporation  from  1972  to  1989.  He  was also Assistant Director of the
Office  of  Management  and Budget, The White House and was formerly a member of
the  Board  of Directors of Pacific Enterprises and Teledyne, Inc. Dr. Rice is a
member  of  the Board of Directors of Wells Fargo & Company and Vulcan Materials
Company.

         Dr.  Sanders  was  elected  a  Director  of Scios in September 1997. He
served  as  Chief  Executive  Officer  of  Glaxo Inc. from 1989 to 1994, and was
Chairman  of  the  Board  from  1992  to  1995.  He  also served on the Board of
Directors  of  Glaxo  plc.  Previously,  he held a number of positions at Squibb
Corporation, a   multinational  pharmaceutical  corporation,  including  Vice 
Chairman,  Chief  Executive  Officer  of  the  Science  and Technology Group and
Chairman of the Science and Technology Committee of the Board.  Dr. Sanders is a
member  of  the  Board  of  Directors  of  Magainin  Pharmaceuticals,  Vertex 
Pharmaceuticals, Staff Mark, Inc., Kendle International, Trimeris, and 
Pharmacopeia.
<PAGE>

         Dr. Schrier was elected a Director of Scios in August 1988. He has been
Professor and Chairman, Department of Medicine, University of Colorado School of
Medicine,  since 1976. He has held numerous positions in professional societies,
including President of the National Kidney Foundation, President of the American
Society of Nephrology,  President of the Association of American Physicians, and
President of the  International  Society of Nephrology.  He received the Pasteur
Award  from the  University  of  Strasbourg;  the John  Phillips  Award from the
American  College of Physicians;  the David Hume Award from the National  Kidney
Foundation;   the  Mayo  Soley  Award  from  the  Western  Society  of  Clinical
Investigation;  and honorary  degrees from the University of Colorado and DePauw
University.  He has also served on the editorial boards of numerous professional
publications,  has authored over 600 scientific articles and has edited numerous
medical texts and reference  books.  He is a member of the Institute of Medicine
of the National Academy of Sciences..

         Dr. Snyder was  elected  a  Director  in September 1992.  Dr. Snyder is
Director  of  the Department of Neuroscience and Distinguished Service Professor
of Neuroscience, Pharmacology and Molecular Sciences and Psychiatry at The Johns
Hopkins University, and has been a member of the faculty there since 1966.  Dr.
Snyder  received  the  Albert  Lasker  Award  for  Basic Biomedical Research and
Honorary  Doctor  of  Science  degrees  from Northwestern University, Georgetown
University  and  Ben  Gurion University.  Dr. Snyder received the Wolfe Award in
Medicine  from the government of Israel for research relating to receptors.  Dr.
Snyder  is  a  member  of  the  National Academy of Sciences and a Fellow of the
American  Academy  of  Arts  and  Sciences.  Dr. Snyder  is  also  the author of
numerous  articles and several books.  Dr. Snyder is a founder and a director of
Guilford Pharmaceuticals Inc.

         Dr. Sobel  was  elected  a  Director  in  February  1996.  Dr. Sobel is
Physician-in-Chief,  E.L.  Amidon  Professor  and  Chair  of  the  Department of
Medicine  at  The  University  of  Vermont College of Medicine.  Previously, Dr.
Sobel  was  Professor  of Medicine at Barnes Hospital, Washington University and
Director of its Cardiovascular Division.  Dr. Sobel has been a consultant to and
served on scientific advisory boards of several pharmaceutical and biotechnology
companies.  Dr. Sobel has  been  the recipient of numerous awards, including the
American Heart Association's James B. Herrick Award and its Scientific Council's
Distinguished Achievement Award, as well as the American College of Cardiology's
Distinguished Scientist Award.  Dr. Sobel  has  been  the editor of  Circulation
and,  since  1989,  has  served  as  editor  of  Coronary  Artery  Disease.  His
memberships and  fellowships  include  the American College of Physicians, Royal
Society of Medicine, American Heart  Association, American College of Cardiology
and the Council of the American Association for the Advancement of Science.

         Mr. Step was elected a Director in February  1993.  From May 1956 until
he  retired  in  December 1992,  Mr. Step was employed by Eli Lilly and Company,
most  recently  as  Executive  Vice  President, President  of the Pharmaceutical
Division, where he was responsible for U.S. pharmaceutical  operations  and  for
the  operations of Eli Lilly International.  In addition, Mr. Step served on Eli
Lilly's Board  of  Directors  and executive committee.  Mr. Step was Chairman of
the  Board  of  Directors of the  Pharmaceutical  Manufacturers  Association and
President  of  the  International  Federation  of  Pharmaceutical  Manufacturers
Associations.  He  is  a  member of the Board of Directors of Cell Genesys Inc.,
Guidant  Corporation,  Medco  Research  Inc., Pathogenesis  Corporation  and DBT
Online Inc.



<PAGE>



                  INFORMATION ABOUT THE BOARD OF DIRECTORS AND
                             COMMITTEES OF THE BOARD

               Compensation of Directors -- Standard Arrangements

         Fees.  Directors who are not otherwise  employed by the Company receive
an annual retainer of $12,000 and a fee of $1,000 for attendance at each meeting
of the Board of Directors, and $500 for attendance at each committee meeting not
occurring  within 24 hours of a Board  meeting or a telephonic  meeting.  In the
fiscal year ended December 31, 1997, the aggregate compensation paid to eligible
non-employee   directors  (8  individuals)   under  standard   arrangements  was
$103,500.00.  This  amount  includes  payments  to Donald B. Rice and Charles A.
Sanders, who were elected Directors of the Company in August and September 1997,
respectively. Directors are also eligible for reimbursement of expenses incurred
in  connection  with  attendance at Board  meetings in  accordance  with Company
policy. If Proposal 2 is approved by the stockholders,  the annual retainer will
be reduced to $8,000 and the fee per meeting day will remain $1,000 and $500 for
telephonic meetings.

         Stock Options.  Upon  election to the Board, each non-employee director
is automatically granted an  option  to  purchase 20,000 shares of Common Stock.
These  options  are  currently granted under the Company's 1992 Equity Incentive
Plan (the "Equity Plan"), which  contains  provisions  for  automatic  grants to
non-employee  directors  and  was  approved  by stockholders in 1992.  Only non-
employee  directors  of  the  Company  are eligible to receive options under the
applicable  provisions  of  the  Equity Plan, and Mr. Armacost, Mr. Du Bain, Dr.
Rice, Dr.  Sanders,  Dr. Schrier, Dr.  Snyder, Dr.  Sobel and Mr. Step have each
received  option  grants.  Proposal  2  would  modify  the  Company's program of
automatic  grants  to  non-employee directors to provide for annual grants.  See
"Proposal 2, Approval of Amendment of 1992 Equity Incentive Plan".

         Board of Directors.  During  fiscal  1997, there were 5 meetings of the
Board of Directors.  

         Audit Committee.  The Audit  Committee  consists  of  four non-employee
directors:  Mr. Step (Chairman), Mr.  Armacost, Dr. Sanders  and Dr. Sobel.  Dr.
Sanders  joined  the  Committee  upon  his  election  as  a Director.  The Audit
Committee met four times in fiscal 1997.  Among  the  committee's  functions are
recommending  engagement  of  the  Company's  independent  auditors,  approving 
services performed by such auditors, and reviewing and evaluating the  Company's
accounting systems and its system of internal accounting controls.

         Compensation Committee.   The  Compensation  Committee consists of five
non-employee  directors:  Mr.  Armacost (Chairman), Mr.  Du Bain, Dr. Rice, Dr. 
Sanders  and Mr.  Step.  Drs. Rice  and Sanders  joined the Committee upon their
election as Directors.  The committee met four  times during fiscal 1997.  Among
the committee's functions are  establishing the  Company's compensation programs
for all employees, fixing the  compensation  levels of executive officers of the
Company, and administering  and  making awards  under  the  Company's  incentive
programs.

         Nominating Committee.  The Nominating  Committee  consists of four non-
employee  directors:  Mr.  Du Bain  (Chairman), Dr.  Rice,  Dr.  Schrier and Dr.
Snyder.  Dr. Rice joined the Committee upon his  election  as  a  Director.  The
committee  met  twice  in  fiscal  1997. Among  the  committee's  functions  are
recommending nominees to serve on the Board of Directors, recommending  size and
composition of the Board based on  studies  conducted by  the committee,  making
recommendations to the Board regarding  stockholders' comments as to composition
of the Board, making recommendations  concerning  membership of Board committees
and Board and committee fees, and consulting with  the  Board  of  Directors and
management to determine criteria for nominations.  The Nominating Committee will
consider  nominees  recommended  by  stockholders.  Any  such  recommendations, 
together with the nominee's qualifications and consent to being  considered as a
nominee, should be sent to the Secretary of the Company no  later  than November
30, 1998 in order to be considered for election  at  the 1999  Annual Meeting of
Stockholders.

         In fiscal 1997, all Directors attended  at least 75% of the meetings of
the Board and all  committees of the Board of which they were members except for
Dr.  Schrier  who  attended  only 29%. In addition,  Dr. Sanders was not able to
attend any of the November meetings following his election as a director.


<PAGE>



           SECURITY OWNERSHIP OF MANAGEMENT AND PRINCIPAL STOCKHOLDERS

                              Beneficial Ownership

         The  following  table  sets forth  certain  information  regarding  the
beneficial  ownership of the Company's Common Stock at March 16, 1998 by (i) all
persons  known by the  Company  to be  beneficial  owners of more than 5% of its
Common Stock, (ii) each Director,  (iii) each of the executive officers named in
the  Summary  Compensation  Table  included  herein and (iv) all  Directors  and
executive officers of the Company as a group.
<TABLE>
<CAPTION>

                                                  Beneficial Ownership(1)
                                        ---------------------------------------                  
                                        Beneficially           Approximate
Officers, Directors &                      Owned                 Percent
5% Stockholders                           Shares(2)              of Class
- -------------------------------------------------------------------------------
<S>                                     <C>                    <C>    

Samuel H. Armacost                       36,000                    *
Richard L. Casey                        402,759(3)                 1%
Myron Du Bain                            52,500(3)                 *
Donald B. Rice, Ph.D.                    12,666                    *
Charles A. Sanders, M.D.                  2,333                    *
Robert W. Schrier, M.D.                  17,800                    *
Solomon H. Snyder, M.D.                  11,333                    *                                                               
Burton E. Sobel, M.D.                     9,000                    *
Eugene L. Step                           21,000                    *

Elliott B. Grossbard, M.D.              197,617                    *
John H. Newman                          166,049(3)                 *
John A. Lewicki, Ph.D.                  152,567                    *
Armin H. Ramel, Ph.D.                    85,254                    *

All officers and directors as a
  group (13 persons)                  1,166,878(3)                 3%
<FN>
- ----------
* less than 1%
(1)      Unless  otherwise  indicated  below and subject to  community  property
         laws,  each  stockholder  has sole  voting  and  investment  power with
         respect to the shares beneficially owned.

(2)      For Mr. Armacost, Mr. Casey, Mr. Du Bain,  Dr.  Rice, Dr. Sanders,  Dr. 
         Schrier, Dr. Snyder, Dr. Sobel, Mr.  Step, Dr.  Grossbard, Dr. Lewicki, 
         Mr. Newman and Dr. Ramel, and all officers  and  directors  as a group,
         includes  11,000;  359,999; 22,500; 2,666; 2,333; 17,500; 1,333; 9,000; 
         20,000;  193,333;  136,666;  103,999; 83,666;  and 963,995 shares, 
         respectively, issuable upon exercise of outstanding options exercisable
         within sixty days of March 16, 1998.

(3)      With respect to  Mr.  Casey,  includes 8,737 shares held in a trust for
         the  benefit  of  Mr. Casey's children, of which Mr. Casey and his wife
         are trustees.  With respect to Mr. Du Bain, includes 25,000 shares held
         in  a  revocable  living  trust  for the benefit of Mr. Du Bain and his 
         wife;  Mr.  Du Bain  is  a  trustee of such trust.  With respect to Mr.
         Newman,  includes  7,000  shares  held  in his spouse's IRA account and
         2,000  shares held in a trust for the benefit of Mr. Newman's children,
         of which Mr. Newman and his wife are trustees.
</FN>
</TABLE>

         The  Company  is not  aware of any  material  proceeding  to which  any
Director  or  executive  officer  of the  Company or any  associate  of any such
Director or  executive  officer is a party  adverse to the Company or any of its
subsidiaries  or has a material  interest  adverse to the  Company or any of its
subsidiaries.

Compliance with Section 16(a) of the Exchange Act

         Section 16(a) of the  Securities  Exchange Act of 1934, as amended (the
"Exchange  Act"),  requires  the  Company's  Directors,  executive  officers and
holders of more than ten  percent  (10%) of the  Company's  Common  Stock  ("10%
Holders")  to file with the  Securities  and  Exchange  Commission  (the  "SEC")
initial reports of ownership and reports of changes in ownership of Common Stock
and other equity securities of the Company.  Directors,  executive  officers and
10% Holders are required by SEC regulation to furnish the Company with copies of
all Section 16(a) forms they file.

         The Company  believes  that during the fiscal year ended  December  31,
1997,  its  Directors,  executive  officers  and 10% Holders  complied  with all
Section 16(a) filing  requirements.  In making this  statement,  the Company has
relied upon the written representations of its Directors, executive officers and
certain other reporting persons.



<PAGE>

                             EXECUTIVE COMPENSATION

         The following  table discloses  compensation  received by the Company's
Chief  Executive  Officer  and each of its four  other most  highly  compensated
executive  officers at December 31, 1997 for the fiscal years ended December 31,
1997, 1996 and 1995.

<TABLE>
<CAPTION>
                           SUMMARY COMPENSATION TABLE

                                                         Long-Term
                                                         Compensation
                         Annual Compensation             Awards

                                                         Securities
Name                                                     Underlying    All Other
and                                                      Stock         Compen-
Principal                          Salary     Bonus(1)   Options       sation(2)
Position                   Year     ($)         ($)       (#)           ($)
- --------                   ----    -------    -------    -------       ----
<S>                        <C>     <C>        <C>        <C>           <C>    

Richard L. Casey           1997    $400,000         --        --       $3,000
  Chairman of the          1996    $400,000   $120,000   100,000       $3,000
  Board, President         1995    $400,000         --   120,000       $3,000
  and Chief Executive
  Officer

Elliott B. Grossbard, M.D. 1997    $246,064         --    19,000       $3,000
  Senior Vice President    1996    $218,500   $105,000(3)  9,375       $3,000
  of Development           1995    $208,000    $60,577(3) 39,000       $3,000

John H. Newman             1997    $212,500         --    19,000       $3,000
  Senior Vice President,   1996    $185,500    $65,000     9,375       $3,000
  General Counsel &        1995    $178,500    $24,425    39,000       $3,000
  Secretary

John A. Lewicki, Ph.D.     1997    $222,000         --    12,000       $3,000
  Vice President           1996    $215,500    $40,000     6,250       $3,000
  of Research              1995    $208,000    $24,904    39,000       $3,000

Armin H. Ramel, Ph.D.      1997    $208,000         --    14,000       $3,000
  Vice President of        1996    $202,000    $42,000     6,250       $3,000
   Product Development     1995    $195,700    $20,084    37,000       $3,000

<FN>
- ---------------
(1)   Except  as is  further  described  in  footnote  3  below,  bonus  amounts 
      represent the value of awards under the Company's Employee Incentive Plan.
      Awards  to  executive  officers under this plan are determined annually by
      the Compensation Committee.  The Compensation Committee determined that in 
      lieu of cash bonuses for  1997  performance, the Company would grant stock 
      options  to  Dr.  Grossbard,  Mr.  Newman,  Dr.  Lewicki  and Dr. Ramel in 
      February, 1998 in the following share amounts: 18,500, 13,500,  10,000 and 
      7,000, respectively.  

(2)   Consists of Company matching contributions under the 401(k) Profit Sharing
      Plan and Trust,  which was  established  in 1986. As of December 31, 1997,
      the  Company  made   matching   contributions   of  100%  of   participant
      contributions,  up to a maximum of $3,000 per  participant  per plan year.
      Employee  contributions  are at  all  times  100%  vested.  The  Company's
      contributions  vest based on years of service:  0% for less than one year;
      25% for one but less  than two  years;  50% for two but  less  than  three
      years;  and 100% for  three or more  years.  Federal  tax laws  impose  an
      overall limit on the amount that may be contributed by  participants  each
      year under 401(k) plans.

(3)   Dr. Grossbard's  bonuses for 1996 and 1995 include  forgiveness of $30,000
      and  $25,000  respectively,  in each year  under a loan made to him at the
      time he joined the Company.
</FN>
</TABLE>
<PAGE>

                        STOCK OPTION GRANTS AND EXERCISES

      In the  Company's  efforts  to  recruit  the best  available  talent  in a
competitive  labor market,  the Company  grants stock options to provide  equity
incentives. The Company has granted stock options under the 1983 Incentive Stock
Option Plan (expired by its terms on March 5, 1993), the 1986 Supplemental Stock
Option Plan  (expired by its terms on January 16, 1996),  the 1989  Non-Employee
Director  Stock Option Plan (expired by its terms on June 30, 1994),  the Equity
Plan and the 1996 Non-Officer Stock Option Plan.

      The  following  table  provides  information  on stock options held by the
executive  officers  named  in  the  Summary   Compensation   Table,   including
information  as to grants and exercises  for the fiscal year ended  December 31,
1997.

                        Option Grants in Last Fiscal Year
<TABLE>
<CAPTION>

                                                                                Potential Realizable Value at
                                                                                Assumed Annual Rates of Stock
                            Individual Grants                                   Price Appreciation for Option Term                 
- --------------------------------------------------------------------------      ----------------------------------- 
                  No. of            % of
                  Securities        Total
                  Under-            Options
                  lying             Granted to       Exercise
                  Options           Employees        or Base      Expira-
                  Granted1/         in Fiscal        Price        tion
Name                (#)             Year             ($/Sh)       Date          0%($)        5%($)          10%($)
- ----              --------          ---------        --------     --------      -----        -----          ------
<S>               <C>               <C>              <C>          <C>           <C>          <C>            <C>          

R. Casey          --                --               --           --            --           --             --

E. Grossbard      19,000            2.31%            $6.13        02/03/07      0            $73,188        $185,472   

J. Newman         19,000            2.31%            $6.13        02/03/07      0            $73,188        $185,472

J. Lewicki        12,000            1.46%            $6.13        02/03/07      0            $46,224        $117,140

A. Ramel          14,000            1.70%            $6.13        02/03/07      0            $53,928        $136.663

<FN>
- ---------
(1)  These  options vest in monthly  installments  commencing on January 1, 1997
     and ending on December 31, 2001. See  "Compensation  Committee  Report" for
     additional  information  on these stock  options.  All grants in this table
     were made pursuant to the 1992 Equity Incentive Plan.
</FN>
</TABLE>
<PAGE>

                 Aggregated Option Exercises in Last Fiscal Year
                            and FY-End Option Values
<TABLE>
<CAPTION>

                                                                                    
                                                    Number of Securities              Value of Unexercised,
                        Shares                     Underlying Unexercised             In-the-Money Options
                     Acquired on     Value           Options at FY-End                     at FY-End
 Name                  Exercise     Realized     Exercisable   Unexercisable       Exercisable(1)  Unexercisable(1)             
 ----                  -------      --------     ----------------------------      -------------------------------                 
                         (#)          ($)                   (#)                                 ($)
<S>                    <C>          <C>          <C>           <C>                 <C>             <C>

R. Casey               0            0            540,000       220,000             $1,487,500      $787,750               

E. Grossbard           0            0            185,000        62,375               $306,875      $194,523

J. Newman              0            0            136,500        57,375               $339,125      $175,148

J. Lewicki             0            0            170,000        57,250               $412,500      $172,516

A. Ramel               0            0             77,000        55,250               $298,375      $167,516

<FN>
- ---------

(1)      Based on the fair market value of the Company's Common Stock at 
         December 31, 1997 ($10.00)  minus the exercise price of the options.
</FN>
</TABLE>

                         COMPENSATION COMMITTEE REPORT (1)

         The Compensation  Committee of the Board of Directors (the "Committee")
is  responsible  for  establishing  the  Company's compensation programs for all
employees, including executives. For executive officers, the Committee evaluates
performance  and  determines  compensation  policies  and  levels.  In 1997, the
Committee  was  composed  of  Mr . Armacost, Mr. Du Bain and Mr. Step and, after
their election to the Board, Dr. Rice  and Dr. Sanders.  None of these directors
were officers or employees of the Company.

Compensation Philosophy

         The goals of the compensation program  are  to  align compensation with
business  objectives  and  performance,  and  to  enable the Company to attract,
retain and reward executive officers and other key employees  who  contribute to
the  long-term success of the Company and to motivate them to enhance  long-term
stockholder value. Key elements of this philosophy are:

          The Company pays  competitively  with leading  biotechnology and other
         companies  with which the Company  competes for talent.  To ensure that
         pay is competitive,  the Company  regularly  compares its pay practices
         with these companies and sets its pay parameters based on this review.

          The Company  maintains  annual incentive  opportunities  sufficient to
         provide  motivation to achieve specific operating goals and to generate
         rewards that bring total compensation to competitive levels.

          The  Company   provides   significant   equity-based   incentives  for
         executives  and other key  employees to ensure that they are  motivated
         over the long-term to respond to the Company's business  challenges and
         opportunities as owners and not just as employees.

- --------
(1)      Notwithstanding  anything  to  the  contrary  set  forth  in any of the
         Company's  previous  filings  under  the  Securities  Act of  1933,  as
         amended, or the Exchange Act that might incorporate by reference future
         filings in whole or in part,  including this Proxy  Statement,  neither
         this Report nor the Performance  Graph in this Proxy Statement shall be
         incorporated by reference into any such filings.
<PAGE>

         The primary  components  of  executive  compensation  are base  salary,
annual incentives and long-term equity incentives. Over the last five years, the
Committee  has not granted a salary  increase to the CEO and has granted  modest
salary  increases over the last three years to other  executives.  These actions
reflect  the  Committee's  intent  to lower  the  relative  percentage  of fixed
compensation (base salary) and increase the relative  percentage of variable pay
or pay based on performance  (long-term  equity  incentives).  In addition,  the
Committee  elected to distribute  annual incentive awards to executives for 1997
performance in the form of additional stock option grants made in February, 1998
that vest over four (4) years.

         The  Committee's  objective  in  general  is to set each  component  of
executive  compensation  at the market  average  when  compared to a  nationwide
survey of the  biotechnology  industry (the  "comparator  group").  In 1997, the
comparator group contained approximately 300 companies. Many of the companies in
the  comparator  group are included in the  Performance  Graph  included in this
Proxy Statement.

         Base Salary.  The Committee  annually reviews each executive  officer's
base salary  against the base salaries  paid for similar  positions by companies
within the  comparator  group.  A range of salary levels is  established by this
comparison  centered on the 50th percentile  salary in the comparator  group for
comparable positions.  Within this range, the Committee  subjectively  considers
individual factors,  including individual performance,  level of responsibility,
prior experience, breadth of knowledge and competitive pay practices, as well as
the extent to which the Company achieved its corporate  objectives  described in
the section below  entitled  Annual  Incentive.  From year to year, the relative
weighting of the individual  components and the corporate  performance component
may differ from  officer to officer,  and can be expected to change over time in
response  to  the  Company's   development   stage  and  the  evolution  of  the
biotechnology industry.

         Annual  Incentive.  The Employee  Incentive  Plan, an annual  incentive
award plan, is the variable pay program for officers and other  employees of the
Company to earn  additional  annual  compensation.  The actual  incentive  award
earned  depends  on the  extent  to which  Company  and  individual  performance
objectives  are achieved.  At the start of each year, the Committee and the full
Board of Directors review and approve the annual performance  objectives for the
Company and individual  officers.  The Company  objectives consist of operating,
strategic  and  financial  goals  that  are  considered  to be  critical  to the
Company's  fundamental  long-term goal -- building stockholder value. For fiscal
1997, these objectives, listed in order of relative importance, were:

                  completing the  key  development  benchmarks for the Company's
                  lead products - AURICULIN(R)  anaritide,  NATRECOR(R) hBNP and
                  FIBLAST(R)   trafermin   -  that  had  been   identified   for
                  accomplishment in 1997

                  securing   commercial  partners  for  certain of the Company's
                  technologies and commercial operations

                  financial  performance  related  to  the  Company's  cash 
                  utilization  and  expanding the sales and profits derived from
                  the  Company's  commercial  operations  group,  which  markets
                  certain products to psychiatrists and mental health clinics

                  identifying  and  developing  additional  products  from  the 
                  Company's research pipeline as candidates for clinical testing
<PAGE>

         After the end of the year, the Committee  evaluates the degree to which
the Company has met its  objectives  and, at the  discretion  of the  Committee,
establishes  a total  incentive  award pool under the Employee  Incentive  Plan.
Individual awards are determined by evaluating the Company's overall performance
and by evaluating  each  participant's  performance  against  objectives for the
year. The incentive award pool is then allocated based on the assessment of each
participant's   contribution   to   achievement   of  corporate  and  individual
objectives. In prior years, awards were paid in cash and distributions were made
in the  February  following  the  performance  year.  As part of its  effort  to
increase the relative  portion of total  compensation to executives that is paid
in the form of long-term equity incentives,  the Committee elected to distribute
annual  incentive  awards  to  executives  for 1997  performance  in the form of
additional stock option grants vesting over four years.  These awards were made 
in February, 1998.

         In  February,  1998,  the  Committee  determined that while the Company
accomplished  significant  achievements  in  fiscal  1997,  not  all of its  key
corporate  objectives that are outlined above were met. The Committee  concluded
that the  following  goals were met:  advancing  NATRECOR into Phase III trials;
preparations  for the NATRECOR NDA filing and facilities  inspections that would
follow successful  completion of clinical programs;  ongoing assistance to Kaken
Pharmaceutical  Co.,  Ltd.,  the  Company's  FIBLAST  licensee in Japan,  and to
American Home Products Corporation,  the Company's Partner for FIBLAST in stroke
and vascular disease; and certain financial objectives. The Committee determined
that in 1997 the Company had not been  successful in filing an NDA for AURICULIN
or  advancing  other  projects  to the degree  planned.  Based on the  Company's
performance,  the  Committee  determined  that  the  total  incentive  pool  for
participants in the Employee Incentive Plan would be 50% of the maximum possible
pool.  Based on its  assessment of individual  contribution  to  achievement  of
corporate and  individual  objectives,  the Committee  determined  the incentive
award for each of the seven  executives  on the Company's  corporate  management
committee reflecting their 1997 performance and distributed it in the form of an
additional stock option grant vesting over four (4) years.

         Long-Term  Incentives.  The Company's  long-term  incentive program for
officers  consists of the 1983  Incentive  Stock Option Plan,  (expired March 5,
1993),  the 1986  Supplemental  Stock Option Plan (expired January 16, 1996) and
the 1992 Equity  Incentive  Plan. The option program  utilizes  vesting  periods
(generally  four years) to encourage  key employees to continue in the employ of
the Company.  Through  option  grants,  executives  receive  significant  equity
incentives to build  long-term  stockholder  value.  Grants have been made at or
above 100% of fair market value on the date of grant.  Executives  receive value
from these  grants  only if the  Company's  Common  Stock  appreciates  over the
long-term.  The  size of  option  grants  is  determined  based  on  competitive
practices at companies in the comparator  group and the Company's  philosophy of
significantly  linking  executive  compensation with stockholder  interests.  In
addition,  the Committee  considers  the terms and number of options  previously
awarded in determining the size of option grants.
<PAGE>

         In 1995, 1996 and 1997, the Committee reviewed the equity incentives of
executive officers and made additional grants in each year to remain competitive
with the comparator group and maintain appropriate  long-term incentives for key
individuals.  These grants will vest during 1997  through  2001.  The  Committee
believes  the approach of making  grants that vest over an extended  time period
creates an appropriate  focus on longer term  objectives and promotes  executive
retention.

         Section  162(m) of the Internal  Revenue Code limits the federal income
tax  deductibility of compensation  paid to the Company's CEO and to each of the
other four most highly compensated executive officers.  The Company intends that
the long-term incentive compensation paid to these executives will be deductible
by the  Company  under  Section  162(m).  In 1997,  the Board  and  stockholders
approved  amendments  to the 1992  Equity  Incentive  Plan  intended to meet the
requirements of Section 162(m).

Chief Executive Officer Compensation

         In the fall of 1992,  the  Committee  retained  Hewitt  Associates  (an
international  employee  compensation and benefits consulting firm) to conduct a
comprehensive  review of the base  salaries and  incentive  compensation  of all
executive  officers as  compared to a  comparator  group.  Following  the Hewitt
Associates  review,  the  Committee  set Mr.  Casey's 1993 base annual salary at
$400,000.  This  amount,  in  addition to the annual  incentive  provided by the
Employee  Incentive  Plan, was estimated to provide an annual cash  compensation
level at the  average of the  comparator  group.  In setting  this  amount,  the
Committee  took into account (i) its belief that Mr. Casey is one of the CEOs of
leading biotechnology  companies with significant and broad-based  experience in
the  pharmaceutical  industry,  (ii) the  scope of Mr.  Casey's  responsibility,
especially following the merger with Nova Pharmaceutical Corporation,  and (iii)
the Board's confidence in Mr. Casey to lead the Company's continued development.

         For 1994 through 1997,  the Committee  elected to maintain Mr.  Casey's
base salary at $400,000,  the same level as 1993. In doing so, the Committee has
intended to increase the relative portion of Mr. Casey's total compensation that
is variable  pay,  which is based on  achievement  of the  corporate  objectives
annually established by the Board and on increases in the Company's stock price.
See "Compensation Philosophy-Annual Incentive" and "Compensation Philosophy-
Long-Term Incentive" above.

         In February,  1996, the Committee  determined that it would enhance Mr.
Casey's incentive to build long-term  stockholder value by granting Mr. Casey an
option to purchase  100,000  shares of stock that will vest in the year 2000. At
the time of this  grant,  the  Committee  determined  that it would  not make an
additional grant to Mr. Casey during 1997.
<PAGE>

Conclusion

         In summary, the Compensation Committee believes that, through the plans
and actions described above, a significant portion of the Company's compensation
program and, in particular,  Mr. Casey's  compensation are contingent on Company
performance,  and that  realization of benefits is closely linked to achievement
of key corporate objectives that will produce increases in long-term stockholder
value. The Company remains  committed to this philosophy of pay for performance,
recognizing  that  the  competitive  market  for  talented  executives  and  the
volatility of the Company's business may result in highly variable  compensation
for  a  particular  time  period.  We  will  continue  to  monitor  closely  the
effectiveness and  appropriateness  of each of the components of compensation to
reflect changes in the Company's business environment.

                                                    COMPENSATION COMMITTEE
                                                    Samuel H. Armacost, Chairman
                                                    Myron Du Bain
                                                    Eugene L. Step
                                                    Donald B. Rice
                                                    Charles A. Sanders


           COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         In 1997,  Scios paid $57,468.80 in portfolio  management fees to Weiss,
Peck & Greer,  L.L.P.,  an investment  firm of which Mr.  Armacost is a managing
director. Such fees were paid in the normal course of business.

                                PERFORMANCE GRAPH

         The rules of the  Securities and Exchange  Commission  require that the
Company  include in this Proxy  Statement a  line-graph  presentation  comparing
five-year  stockholder  returns on an indexed basis with the Nasdaq Stock Market
(U.S.) and either a nationally recognized industry standard index or an index of
peer  companies  selected  by the  Company.  The  Company has elected to use the
Nasdaq Pharmaceutical Stocks Index for the purpose of the performance comparison
that appears  below.  The graph assumes the  investment of $100 in the Company's
Common  Stock,  the Nasdaq  Stock  Market  (U.S.) and the Nasdaq  Pharmaceutical
Stocks  Index on December  31, 1992.  The stock price  performance  shown on the
graph below is not necessarily indicative of future price performance.


<PAGE>

                 Comparison of Five Year Cumulative Total Return
                Among Scios Inc., Nasdaq Stock Market (U.S.) and
                       Nasdaq Pharmaceutical Stocks Index

EDGAR representation of data points used in printed graphic

<TABLE>
<CAPTION>
                           Scios                 Nasdaq Stock Market           Nasdaq Pharm
                           -----                 -------------------           ------------
          <S>              <C>                   <C>                           <C>   

          12/31/92         100.000               100.000                       100.000
           1/29/93          82.432               102.847                        92.948
           2/26/93          72.973                99.010                        71.341
           3/31/93          75.676               101.876                        71.984
           4/30/93          64.865                97.528                        72.740
           5/28/93          64.865               103.354                        75.720
           6/30/93          60.811               103.832                        75.860
           7/30/93          62.162               103.954                        73.683
           8/31/93          72.973               109.327                        77.609
           9/30/93          81.081               112.583                        82.242
          10/29/93         118.919               115.114                        89.515
          11/30/93         112.162               111.682                        87.551
          12/31/93         110.811               114.796                        89.132
           1/31/94         101.351               118.281                        91.842
           2/28/94          93.243               117.177                        83.574
           3/31/94          79.730               109.971                        72.698
           4/29/94          85.135               108.544                        69.773
           5/31/94          72.297               108.809                        68.831
           6/30/94          68.919               104.830                        63.455
           7/29/94          68.919               106.980                        65.375
           8/31/94          82.432               113.800                        72.469
           9/30/94          72.973               113.509                        71.469
          10/31/94          72.973               115.740                        69.026
          11/30/94          64.865               111.900                        69.331
          12/30/94          71.622               112.214                        67.084
           1/31/95          83.784               112.843                        70.798
           2/28/95          89.189               118.811                        73.472
           3/31/95          82.432               122.334                        72.422
           4/28/95          72.973               126.186                        74.456
           5/31/95          38.514               129.442                        75.395
           6/30/95          43.919               139.932                        84.228
           7/31/95          45.946               150.218                        91.480
           8/31/95          44.595               153.262                       102.300
           9/29/95          44.595               156.787                       105.244
          10/31/95          39.189               155.888                       101.302
          11/30/95          41.892               159.549                       106.385
          12/29/95          46.622               158.699                       122.722
           1/31/96          58.108               159.482                       133.452
           2/29/96          53.378               165.552                       130.874
           3/29/96          49.324               166.101                       127.685
           4/30/96          51.351               179.882                       134.277
           5/31/96          79.054               188.141                       138.823
           6/28/96          71.622               179.660                       124.029
           7/31/96          60.811               163.658                       110.568
           8/30/96          62.162               172.828                       118.580
           9/30/96          66.892               186.048                       126.865
          10/31/96          62.162               183.993                       121.139
          11/29/96          62.162               195.367                       119.411
          12/31/96          66.385               195.192                       123.079
           1/31/97          64.189               209.064                       133.429
           2/28/97          77.703               197.506                       134.288
           3/31/97          73.649               184.612                       116.886
           4/30/97          50.676               190.384                       109.958
           5/30/97          68.243               211.969                       126.527
           6/30/97          68.919               218.452                       126.180
           7/31/97          86.486               241.510                       129.780
           8/29/97          81.081               241.142                       128.240
           9/30/97         105.405               255.404                       141.556
          10/31/97          88.514               242.129                       134.322
          11/28/97          81.757               243.326                       130.203
          12/31/97         108.108               239.527                       127.185
</TABLE>
<PAGE>

                     CERTAIN RELATIONSHIPS AND TRANSACTIONS

         In 1993, the Company formed Guilford Pharmaceuticals Inc. ("Guilford").
Mr. Casey and Dr. Snyder are directors of Guilford.  The Company currently owns 
approximately 7% of the outstanding stock of Guilford.  In 1997, Guilford rented
space from the Company, for which it paid  $255,150.


                                   PROPOSAL 2
               APPROVAL OF AMENDMENT OF 1992 EQUITY INCENTIVE PLAN

         In February 1992, the Board of Directors adopted,  and the stockholders
subsequently  approved,  the Company's  1992 Equity  Incentive Plan (the "Equity
Plan").  In February  1998,  the  Nominating  Committee,  as part of its duty of
overseeing the compensation of non-employee directors, reviewed the stock option
grants to non-employee  directors made by a comparator group of 26 biotechnology
companies. That review disclosed that the shares of Common Stock currently being
vested by  non-employee  directors of the Company on an annual basis under stock
option  grants is lower in number  and value than the  average  number of shares
being vested on an annual  basis by  non-employee  directors  of the  comparator
companies.  The  Nominating  Committee  and the Board believe that this puts the
Company  at a  disadvantage  in terms of  recruiting  and  retaining  directors.
Subject to stockholder  approval,  the Nominating Committee has proposed and the
Board of Directors has approved a change in the automatic stock option grants to
non-employee   directors   under  the  Equity  Plan.  This  Proposal  now  seeks
stockholder  approval for that change.  The  Nominating  Committee and the Board
believe that  increasing  the portion of director  compensation  represented  by
stock  options  would  further  align  non-employee  directors'  interests  with
stockholders and provide further incentive to build long-term stockholder value.

         Stockholders  are requested in this Proposal to approve an amendment of
the Equity Plan to provide that each non-employee  director of the Company shall
automatically  be granted,  at each annual meeting where the director is elected
to the Board,  a  supplemental  stock option to purchase  ten thousand  (10,000)
shares of the Company's Common Stock.  This would replace the current  automatic
stock option granting  practices as approved by stockholders in 1992. The Equity
Plan  currently  provides that upon election to the Board each new  non-employee
director  receives an option to purchase  20,000 shares of the Company's  Common
Stock  vesting  over a five (5) year  period of  service  as a  director  of the
Company.  At five year  intervals  thereafter  assuming  continued  service as a
director,   each  non-employee  director  receives  an  option  to  purchase  an
additional  10,000 shares of the Company's  Common Stock vesting over a five (5)
year period.  All options are granted  with an exercise  price equal to the fair
market value of the Company's Common Stock on the date of the grant.

                        THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 2.

                  The essential  features of the Equity Plan that are applicable
to non-employee directors are outlined below:

GENERAL

         Non-employee  directors are only eligible for the grant of nonstatutory
stock options under the Equity Plan.  The granting and terms of such options are
subject  to the  following  special  provisions  of the Equity  Plan.  Except as
described  below,   Non-Employee  Director  Options  are  subject  to  the  same
provisions of the Equity Plan applicable to other nonstatutory stock options.
<PAGE>

         Automatic  Grants.  As amended,  the Equity Plan would  provide for the
automatic grants of options to purchase shares of Common Stock of the Company to
non-employee directors. Pursuant to the terms of the Equity Plan, at each annual
election,  a non-employee  director shall  automatically be granted an option to
purchase  10,000  shares of the  Company's  Common  Stock.  The number of shares
automatically  granted  will be  prorated  for any  person  who is  elected as a
non-employee  director for the first time at other than a regular annual meeting
of  stockholders.  The first grant under the revised  schedule  will not be made
until approval of this Proposal by the  stockholders  at the 1998 Annual Meeting
of Stockholders.

         Term.  Non-Employee  Director  Options under the Equity Plan have a ten
year term; however, each such option will terminate prior to the expiration date
if the optionee's service as a non-employee director terminates.  In that event,
the Non-Employee Director Option will terminate twelve months following the date
of  termination  of  service,  unless the  termination  of service is due to the
optionee's  death or disability,  in which case the option will terminate on the
earlier of the  expiration  date or eighteen  months  following  the date of the
optionee's death or disability.  The term of a Non-Employee  Director Option may
be extended if exercise within the periods is prohibited for specified reasons.

         Exercise  Price;  Payment.  The  exercise  price  of each  Non-Employee
Director  Option under the Equity Plan must be equal to the fair market value of
the Company's  Common Stock on the date of grant.  Payment of the exercise price
is due in full in cash at the time of exercise  when the number of shares  being
purchased is less than 1,000 shares;  when the number of shares being  purchased
is 1,000 or more shares, the optionee may elect to make payment under one of the
following  alternatives:  (i) in cash at the time of  exercise;  (ii) payment by
delivery of shares of the  Company's  Common Stock already owned by the optionee
for at least six  months;  or (iii)  payment  by a  combination  of the  methods
specified above.

         Exercise. Non-Employee Director Options under the Equity Plan, as it is
proposed  to  be  amended  will  become  exercisable  in  twelve  equal  monthly
installments  after the date of grant.  Subject to the  satisfaction  of certain
conditions,  each option will be exercisable with respect to each installment on
or after the date of vesting applicable to such installment.

         New  Plan   Benefits.   Following   approval  of  the  Proposal,   each
non-employee  director  will be  automatically  granted  at the May 1998  Annual
Meeting of  Stockholders,  and at each  subsequent  annual meeting at which such
director is  reelected,  an option to purchase  10,000  shares of the  Company's
Common Stock. The exercise price of each option will be the closing price of the
Company's  Common  Stock  on  the  grant  date.  In  the  aggregate,  the  eight
non-employee  directors  will receive in May, 1998,  options to purchase  80,000
shares  at the  May  1998  Annual  Meeting.  Thereafter,  a  grant  will be made
automatically  to each  non-employee  director at the time of each reelection of
the director at an Annual Meeting of Stockholders.

FEDERAL INCOME TAX INFORMATION

         There are no tax  consequences to the optionee or the Company by reason
of the grant of a nonstatutory stock option to the non-employee  director.  Upon
exercise of a nonstatutory stock option, the non-employee director normally will
recognize taxable ordinary income equal to the excess of the stock's fair market
value on the date of exercise over the option  exercise  price.  Generally,  the
Company will be entitled to a business  expense  deduction  equal to the taxable
ordinary income realized by the non-employee  director.  Upon disposition of the
stock,  the  director  will  recognize  a  capital  gain  or loss  equal  to the
difference  between  the  selling  price and the sum of the amount paid for such
stock plus any amount recognized as ordinary income upon exercise of the option.
Such gain or loss will be long or short-term  depending on whether the stock was
held for more than one year.
<PAGE>

         The foregoing  discussion is not a complete  description of the federal
income tax aspects of stock awards to non-employee  directors  granted under the
Equity Plan. In addition,  administrative  and judicial  interpretations  of the
application of the federal  income tax laws are subject to change.  Furthermore,
no  information  is given  with  respect  to state  or local  taxes  that may be
applicable.

The Board of Directors unanimously recommends a vote FOR proposal 2.

                                   PROPOSAL 3
                      RATIFICATION OF INDEPENDENT AUDITORS

         Upon  recommendation of the Audit Committee,  the Board of Directors of
the Company appointed  Coopers & Lybrand L.L.P. to be the Company's  independent
auditors for the fiscal year ending December 31, 1998.

         Services  provided  to the Company  and its  subsidiaries  by Coopers &
Lybrand  with  respect  to the fiscal  year ended  December  31,  1997  included
examination of the Company's consolidated financial statements,  limited reviews
of  quarterly   reports,   services   related  to  filings  with  the  SEC,  and
consultations concerning information systems and various tax matters.

         Coopers  & Lybrand  has  audited  the  Company's  financial  statements
annually  since the Company's  inception in 1982.  Representatives  of Coopers &
Lybrand are expected to be present at the Annual Meeting.  They do not expect to
make a  statement,  but will have the  opportunity  to make a statement  if they
desire to do so and will be available to respond to appropriate questions.

         Stockholder  ratification  of the selection of Coopers & Lybrand as the
Company's  independent  auditors  is not  required  by the  Company's  Bylaws or
otherwise.  However,  the Board is submitting the selection of Coopers & Lybrand
to the stockholders for ratification as a matter of good corporate practice.  If
the  stockholders  fail to ratify  this  selection,  the Board  will  reconsider
whether or not to retain that firm. Even if the selection is ratified, the Board
in  its  discretion  may  direct  the  appointment  of a  different  independent
accounting  firm at any time  during  the year if the  Board  feels  that such a
change would be in the best interests of the Company and its stockholders.

         Ratification  of the  selection  of Coopers & Lybrand as the  Company's
independent  auditors for fiscal year 1998 will require the affirmative  vote of
at least a majority of the shares of Common  Stock  represented  in person or by
proxy and entitled to vote at the Annual Meeting.

The Board of Directors unanimously recommends a vote FOR Proposal 3.
<PAGE>


                                  OTHER MATTERS

         The Board of  Directors  does not know of other  matters  that may come
before the meeting.  However, if any other matters are properly presented to the
meeting,  it is the intention of the persons named in the accompanying  proxy to
vote, or otherwise to act, in accordance with their judgment on such matters.

                   STOCKHOLDER PROPOSALS - 1999 ANNUAL MEETING

         Stockholders  are  entitled  to  present  proposals  for  action  at  a
forthcoming  stockholder  meeting if they  comply with the  requirements  of the
proxy rules.  Proposals of stockholders that are intended to be presented at the
Company's 1999 Annual Meeting of Stockholders must be received by the Company no
later than November 30, 1998 in order to be included in the proxy  statement and
proxy relating to that meeting.

                                 By Order of the Board of Directors

                                 JOHN H. NEWMAN
                                 Secretary
March 31, 1998

THE BOARD OF DIRECTORS HOPES THAT STOCKHOLDERS WILL ATTEND THIS MEETING. WHETHER
OR NOT YOU PLAN TO  ATTEND,  YOU ARE  URGED TO  COMPLETE,  SIGN AND  RETURN  THE
ENCLOSED PROXY IN THE ACCOMPANYING ENVELOPE. STOCKHOLDERS WHO ATTEND THE MEETING
MAY VOTE THEIR SHARES PERSONALLY EVEN THOUGH THEY HAVE SENT IN THEIR PROXIES.

<PAGE>

                                  DETACH HERE


                                   SCIOS INC.

             PROXY FOR ANNUAL MEETING OF STOCKHOLDERS MAY 12, 1998

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS


     The undersigned hereby appoints Richard L. Casey and John H. Newman, or 
either of them, each with full power of substitution, as proxies of the 
undersigned, to attend the Annual Meeting of Stockholders of Scios Inc., to be
held at the offices of the Company, 2450 Bayshore Parkway, Mountain View,
California, on May 12, 1998 at 10:00 a.m. and at any adjournment or 
postponement thereof, to vote the number of shares the undersigned would be
entitled to vote if personally present, and to vote in their discretion upon any
other business that may properly come before the meeting.

     THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED IN THE MANNER DIRECTED
HEREIN.  IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED FOR PROPOSALS 1,2 AND
3.

     Please sign, date and return this proxy in the envelope provided, which
requires no postage if mailed in the United States.


                                                         -----------
                                                         SEE REVERSE
        CONTINUED AND TO BE SIGNED ON REVERSE SIDE          SIDE
                                                         -----------
<PAGE>

                                  DETACH HERE

      PLEASE MARK
/ X / VOTES AS IN
      EXAMPLE

- -------------------------------------------------------------------------------
       The Board of Directors recommends a vote FOR Proposals 1,2 and 3.
- -------------------------------------------------------------------------------
1.   Election of Directors.
NOMINEES:  Samuel H. Armacost, Richard L. Casey, Myron Du Bain, Donald B. Rice,
Charles A. Sanders, Robert W. Schrier, Burton E. Sobel, Solomon H. Snyer, Eugene
L. Step

          FOR            WITHHELD                      MARK HERE
          / /              / /                         IF YOU PLAN
                                                       TO ATTEND
                                                       THE MEETING    / /
/ / __________________________________________
    For all nominees except as noted above
                                                       MARK HERE
                                                       FOR ADDRESS
                                                       CHANGE AND
                                                       NOTE BELOW     / /

2.   To ratify and aprove amendments to                FOR    AGAINST    ABSTAIN
     the Company's 1992 Equity Incentive Plan.         / /      / /        / /

3.   To ratify the election of Coopers &               FOR    AGAINST    ABSTAIN
     Lybrand LLP as the Company's independent          / /      / /        / /
     auditors for fiscal 1998.


(Please sign exactly as name appears.  When shares are held by joint tenants, 
both should sign.  When signing as attorney, as executor, administrator, trustee
or guardian, please give full title as such.  If a corporation, please sign in
full corporate name by President or other authorized officer.  If a partnerhsip,
please sign in partnership name by authorized person.)


Signature:_________________ Date:______ Signature:_________________ Date:_______




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