SCIOS INC
8-K, 1998-10-29
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                ----------------

                                    FORM 8-K

                                 CURRENT REPORT
                       PURSUANT TO SECTION 13 OR 15(D) OF
                       THE SECURITIES EXCHANGE ACT OF 1934


       Date of report (Date of earliest event reported) September 15, 1998


                                   SCIOS INC.
               (Exact Name of Registrant as Specified in Charter)



    Delaware                       0-11749                       95-3701481
(State of Other Jurisdiction      (Commission                   (IRS Employer
  of Incorporation)                File Number)              Identification No.)



             2450 Bayshore Parkway, Mountain View, California 94043
                    (Address of Principal Executive Offices)



        Registrant's telephone number, including area code (650) 966-1550






<PAGE>




Item 5.  Other Events

         On  September  15, 1998,  Scios Inc.  announced  that it had  appointed
Richard B. Brewer as President  and Chief  Executive  Officer and a director and
that Richard L. Casey had retired as an officer and director.  The press release
is attached hereto as Exhibit 99.1 and incorporated herein by reference.


Exhibits.

         99.1     Press Release dated September 15, 1998









         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant has duly caused this amendment to be signed on its behalf of the
undersigned, thereunto duly authorized.

                                            SCIOS INC.


Date:  October 27, 1998                     By:     /s/ John H. Newman         
                                                  ------------------------------
                                                  John H. Newman
                                                  Senior Vice President


<PAGE>



                                INDEX TO EXHIBITS

                                   SCIOS INC.

                    Report on Form 8-K dated October 27, 1998


<TABLE>
<CAPTION>
Exhibit           Description                                      Method of Filing
<S>               <C>                                              <C>    
99.1              Press Release dated September 15, 1998           Filed electronically herewith
</TABLE>




                                  EXHIBIT 99.1


            SCIOS NAMES RICHARD B. BREWER AS CHIEF EXECUTIVE OFFICER
                --Richard L. Casey Retires as Chairman and CEO --


MOUNTAIN VIEW, CA -September 15, 1998--Scios Inc. (Nasdaq: SCIO) announced today
that  Richard B. Brewer has  been named  the  company's  new  president and CEO,
following the retirement of current chairman and CEO Richard Casey as an officer
and director. Mr. Brewer has also been elected a director of Scios.

         Mr. Brewer brings more than 20 years of health care industry experience
and leadership to Scios,  most recently as Chief Operating Officer of Heartport,
a cardiovascular  device company.  Mr. Brewer held a number of senior management
positions  during  his  11-year  tenure  at  Genentech,  including  senior  vice
president,  where he had significant involvement in the strategic development of
Genentech's  product  pipeline,  and  responsibility  for  building  Genentech's
European and Canadian  business and its U.S.  sales and marketing  organization.
Prior to  joining  Genentech,  he held a  variety  of  cardiovascular  sales and
marketing positions at G.D. Searle and Company.

         "Dick Brewer  comes to Scios with a strong  track record of  leadership
and  innovation.  His reputation as a seasoned  executive at the cutting edge of
the development of new  cardiovascular  agents and devices will serve Scios well
as we prepare to bring Scios' product  Natrecor(R)  (nesiritide)  to market with
our  partner,  Bayer,"  said  Myron  Du Bain,  chairman  of the  Scios  board of
director's  search  committee.  "Going forward,  Dick's  expertise in successful
strategic product development will add further value to our exciting pipeline of
new products," Du Bain continued.

         "Rich Casey has led the company over the last 11 years,  and forged and
implemented   the  strategy   that  has  brought   Scios  to  the  threshold  of
profitability and marketing approval of its first product,  Natrecor.  The board
has  honored  Rich's  desire  to  seek  new  challenges,  but he will  remain  a
consultant  to the  company  for  the  next  two  years.  We  thank  him for his
contributions and wish him the best of luck in the future," said Du Bain.


<PAGE>
         Scios submitted a new drug  application  (NDA) for Natrecor to the U.S.
Food and Drug  Administration  (FDA) in April 1998 and  announced  its strategic
alliance  with Bayer AG for the worldwide  commercialization  of Natrecor in May
1998.  Upon approval,  Natrecor will be the first new therapy for the short-term
treatment of congestive  heart failure (CHF) in nearly a decade.  CHF affects an
estimated  4.9  million  Americans  and is  responsible  for nearly one  million
hospitalizations  each year.  CHF is the leading  cause of  hospitalizations  of
patients over the age of 65.

          "Scios  has  an  important  and  valuable  cardiovascular  product  in
Natrecor,  which is rapidly  nearing  the market as a  treatment  for CHF.  With
Natrecor on the horizon and exciting products under development, Scios is poised
to deliver on its objective of bringing  innovative and valuable new products to
market," said Brewer.  "I look forward to joining  forces with the Scios team as
we strive to realize our goal of increasing the company's value for stockholders
through the successful  development of Scios' significant  product pipeline," he
added.

         Scios  is  a  biopharmaceutical   company  engaged  in  the  discovery,
development,  manufacture  and  commercialization  of novel  human  therapeutics
focusing in the areas of cardiorenal  and Alzheimer's  disease.  The company has
research   and   development   collaborations   with   Bayer  AG,   Wyeth-Ayerst
Laboratories, the pharmaceutical division of American Home Products Corporation,
Eli Lilly and Company, DuPont Pharmaceuticals Company, Kaken Pharmaceutical Co.,
Ltd.,  and Novo Nordisk A/S.  Additional  information is available at Scios' web
site: http://www.sciosinc.com.

         The statements in this press release that are not historical  facts are
forward-looking  statements that involve risks and uncertainties and may include
Scios' ability to obtain marketing approval of Natrecor,  Bayer's implementation
of an effective  sales and  marketing  strategy  for  Natrecor in a  competitive
healthcare  environment,  and Scios' successful  development and approval of its
other products,  as well as other risks detailed from time to time in the Scios'
SEC  reports,  including  its  annual  report  on Form  10-K for the year  ended
December 31, 1997 and on quarterly reports on Form 10-Q for subsequent quarters.
                               # # # # # #

Release No. 98-15

Contact: Mary Ann Allencourt, 650-940-6629



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