SCIOS INC
PREC14A, 1999-12-17
PHARMACEUTICAL PREPARATIONS
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                                   Scios Inc.
                              820 West Maude Avenue
                               Sunnyvale, CA 94086
                                   ----------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                                February 28, 2000
                                ___________ __.m.

                                 --------------

To the Stockholders:

NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders of Scios Inc., a
Delaware     corporation     (the     "Company"),     will     be     held    at
___________________________, at ________ __.m. on February 28, 2000, to consider
and act upon the following matters:

         (1)      To elect directors of the Company to serve for the ensuing
year and until their successors are elected.

         (2)  To  ratify  the  selection  of  PricewaterhouseCoopers  LLP as the
Company's independent auditors for fiscal 2000.

         (3)      To act upon such other matters that may properly come before
the meeting or any  adjournment or  postponement of the meeting.

         The foregoing  items of business are more fully  described in the proxy
statement  accompanying this notice. Only stockholders of record at the close of
business  on January  11, 2000 will be entitled to notice of and to vote at this
meeting and any adjournment or postponement  thereof.  For ten days prior to the
meeting, a complete list of stockholders entitled to vote at the meeting will be
available  for  examination  by any  stockholder  for  purposes  relating to the
meeting,  during ordinary  business hours at the Company's office located at 749
North Mary Avenue, Sunnyvale, California 94086.

                                 By Order of the Board of Directors

                                 JOHN H. NEWMAN
                                 Secretary
Sunnyvale, California
_________________, 2000

ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.  WHETHER
OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE,  DATE, SIGN AND RETURN
THE  ENCLOSED  GOLD  PROXY AS  PROMPTLY  AS  POSSIBLE  IN ORDER TO  ENSURE  YOUR
REPRESENTATION  AT THE MEETING.  A RETURN ENVELOPE (WHICH IS POSTAGE PRE-PAID IF
MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE.

THE BOARD OF DIRECTORS URGES YOU NOT TO SIGN ANY WHITE PROXY CARD SENT TO YOU BY
THE KIRK GROUP.  IF YOU HAVE ALREADY DONE SO, YOU MAY REVOKE  YOUR  PREVIOUSLY
SIGNED  WHITE PROXY BY  DELIVERING  A WRITTEN  NOTICE OF  REVOCATION  OR A LATER
DATED GOLD PROXY CARD IN THE ENCLOSED ENVELOPE. EVEN IF YOU HAVE GIVEN YOUR
PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE NOTE,
HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER
NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST OBTAIN FROM THE RECORD
HOLDER A PROXY ISSUED IN YOUR NAME.


<PAGE>


                                   Scios Inc.
                              820 West Maude Avenue
                           Sunnyvale, California 94086
                                 ----------

                                 Proxy Statement
                          Annual Meeting of Stockholders
                                February 28, 2000


General

         The enclosed  proxy is solicited on behalf of the Board of Directors of
Scios Inc., a Delaware  corporation  (the "Company" or "Scios"),  for use at its
Annual Meeting of Stockholders to be held at  ____________________________  , at
________ __.m. on February 28, 2000, and at any  adjournment or  postponement of
that meeting,  for the purposes set forth herein and in the accompanying  Notice
of Annual Meeting. The approximate mailing date for this Proxy Statement and the
enclosed proxy is ___________, 2000.

         The Board of  Directors  has fixed the close of business on January 11,
2000 as the record date for the  determination of stockholders  entitled to vote
at the Annual Meeting. At that time, there were _________ shares of Common Stock
issued and outstanding (not including any treasury shares).

Voting

         Each share of Common Stock issued and outstanding on the record date is
entitled  to one vote.  In the  election  of  directors,  the  seven  candidates
receiving  the highest  number of  affirmative  votes of the shares  present and
voting at the  Annual  Meeting  at which a quorum  is  present  will be  elected
directors.  See  "Nominations  by the Kirk  Group"  below.  With  respect to the
election  of  directors,  where  no vote is  specified  on a  proxy,  the  votes
represented  by the GOLD  proxy  card  will be cast,  at the  discretion  of the
proxies  named  therein,  for all the  candidates  nominated  by the  Board.  An
affirmative  vote of a majority of the shares  present and voting at the meeting
is generally  required for approval of any other items properly submitted to the
stockholders for their consideration.

         The presence at the Annual  Meeting in person or by proxy of a majority
of the  shares  outstanding  as of the  record  date will  constitute  a quorum.
Abstentions and broker  non-votes are counted towards a quorum.  Abstentions are
counted in tabulations of the votes cast on proposals  presented to stockholders
and have the effect of negative votes,  whereas broker non-votes are not counted
for any purpose in determining whether a proposal has been approved.

Revocability of Proxies

         Any person giving a proxy in the form accompanying this Proxy Statement
has the power to revoke it at any time before its exercise. It may be revoked by
filing with the  Secretary of the Company an  instrument of revocation or a duly
executed  proxy  bearing a later date.  It also may be revoked by attending  the
meeting and voting in person. Attendance at the meeting will not itself revoke a
proxy.

Solicitation of Proxies

         Solicitation  of proxies may be made by  directors,  officers and other
employees of the Company named on Appendix A by personal  interview,  telephone,
telegraph, telefax or electronic communications. No additional compensation will
be paid  for any  such  services.  Costs  of  solicitation  will be borne by the
Company.  Upon  request,  the Company will  reimburse  the  reasonable  fees and
expenses  of  banks,  brokerage  houses or other  nominees  or  fiduciaries  for
forwarding proxy materials to, and obtaining  authority to execute proxies from,
beneficial owners for whose accounts they hold shares of Common Stock.

         The Company has retained  MacKenzie  Partners,  Inc.  ("MacKenzie")  to
assist in the solicitation of proxies.  Pursuant to the Company's agreement with
MacKenzie,  it will provide various proxy advisory and solicitation services for
the Company at a cost of $___________,  plus reasonable  out-of-pocket  expenses
and indemnification  against certain liabilities.  It is expected that MacKenzie
will use approximately ____ persons in such solicitation.

<PAGE>

         Certain  information  concerning  the  directors,  officers  and  other
employees  of the  Company  who may  solicit  proxies is  attached to this Proxy
Statement as Appendix A. Certain information concerning the Common Stock held by
the persons  listed in Appendix A and certain  transactions  between any of them
and the Company is set forth in Appendix B.

         Although  no precise  estimate  can be made at this time,  the  Company
anticipates  that the aggregate  amount to be spent by the Company in connection
with  the   solicitation  of  proxies  by  the  Company  will  be  approximately
$___________,  of which  approximately  $____________ has been incurred to date.
This amount includes the fees payable to MacKenzie but excludes (i) the salaries
and expenses of officers,  directors, and employees of the Company; and (ii) the
normal  expenses of an uncontested  election.  The aggregate  amount to be spent
will vary depending on, among other things,  any developments  that may occur in
the proxy contest described below.

         Please complete,  date and sign the enclosed GOLD proxy card and return
it promptly in the envelope provided.  If your shares are held in "street name,"
only your  bank or  broker  can vote  your  shares  and only upon your  specific
instructions.  Please  contact  the  person  responsible  for your  account  and
instruct him or her to vote the GOLD proxy card as soon as possible.

         The Board of Directors  urges you NOT TO SIGN any WHITE proxy card sent
to you by the Kirk Group. See "Nominations by the Kirk Group" below. If you have
already done so, you may revoke your previously signed WHITE proxy by delivering
a written  notice of revocation or a later dated GOLD proxy card in the enclosed
envelope.

<PAGE>

                          NOMINATIONS BY THE KIRK GROUP

         In a letter dated December 2, 1999 (the "Kirk Group Notice")  Randal J.
Kirk,  and certain  entities  (the "Kirk  Group")  notified  the Company that it
intended to nominate eight individuals for election to the Board. The Kirk Group
consists of Mr. Kirk and each of the  following  entities that Mr. Kirk directly
controls: RJK, L.L.C., a Virginia limited liability company, Kirkfield,  L.L.C.,
a Virginia limited  liability  company,  and the Kirk Family  Investment Plan, a
joint account.  Mr. Kirk has filed the Kirk Group Notice with the Securities and
Exchange  Commission  in an amendment to a Schedule 13D dated  December 3, 1999.
That Schedule 13D contains his information regarding his nominees.

         The Board is convinced that the election of new directors  nominated by
the Kirk Group would run directly counter to the best interests of the Company's
stockholders. The Board is intimately familiar with the Company and the industry
in which it operates.  The Board is fully committed to maximizing  value for all
of the Company's  stockholders;  and the Company has made significant strides in
restructuring  its business  since the hiring of Richard Brewer as President and
CEO in September  1998.  The Board  believes  that a change in the Board at this
time would be highly disruptive to the strategy the Company is actively pursuing
and could raise significant  concerns with current and future business partners.
It would  also be highly  unsettling  to our key  personnel,  who are unique and
important assets to the Company,  and thereby disrupt or delay completion of the
important Natrecor(R) clinical trial currently underway.

         The Company is not  responsible  for the  accuracy  of any  information
provided  by or  relating  to the Kirk  Group  contained  in its  notice  to the
Company,  in any proxy  materials filed or disseminated by the Kirk Group or any
other statement it may make.

         THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT STOCKHOLDERS VOTE IN
FAVOR OF THE NOMINEES OF THE BOARD DESCRIBED IN PROPOSAL 1 BELOW AND NOT VOTE IN
FAVOR OF THE NOMINEES OF THE KIRK GROUP.

                                  PROPOSAL 1
                              ELECTION OF DIRECTORS

         As noted below,  Myron Du Bain is retiring as a Director of the Company
upon the election of the Board at the Annual Meeting.  Accordingly,  pursuant to
the procedure  set forth in the  Company's  Certificate  of  Incorporation,  the
number  of  Directors  of the  Company  has  been  reduced  from  eight to seven
effective immediately prior to the election of directors at the Annual Meeting
and  accordingly a Board of seven  (7)  Directors  will be  elected.  The term
of  office of each person so elected as a Director will continue until the next
annual meeting or until a successor  has been  elected.  Unless  otherwise
instructed,  the proxy holders will vote the GOLD proxy cards  received by them
for the seven  nominees of the Board of Directors  named below,  all of whom are
presently  Directors of the  Company.  The  candidates  receiving a plurality of
the votes of the shares present in person or  represented  by proxy at the
meeting and  entitled to vote will be  elected.  Each person  nominated for
election  has agreed to serve if elected, and management has no reason to
believe that any nominee will be unable to serve.  If any nominee for any reason
is unable or declines to serve, the proxies will be voted for any substitute
nominee who shall be designated by the present Board of  Directors to fill the
vacancy.  Stockholders who desire to nominate persons for election to the Board
must comply with the advance notice procedures specified in the Company's
Bylaws.

         The  following  is  information   regarding  the  nominees,   including
information furnished by them as to their principal occupation for the past five
years, certain directorships and their ages as of December 31, 1999.

<TABLE>
<CAPTION>
                                                                                     Director
          Name                                    Age                                Since
          ----                                    ---                                --------
         <S>                                     <C>                                <C>

          Samuel H. Armacost                      60                                 1995
          Richard B. Brewer                       48                                 1998
          Donald B. Rice, Ph.D.                   60                                 1997
          Charles A. Sanders, M.D.                67                                 1997
          Solomon H. Snyder, M.D.                 61                                 1992
          Burton E. Sobel, M.D.                   62                                 1996
          Eugene L. Step                          70                                 1993
</TABLE>


<PAGE>

         Mr.  Armacost was elected to the Company's Board of Directors in August
1995. In July 1998, Mr.  Armacost  became  Chairman of the Board of Directors of
SRI International.  From 1990 to 1998, he was a Managing Director of Weiss, Peck
& Greer, L.L.C., an investment firm. He was a Managing Director of Merrill Lynch
Capital Markets from 1987 to August 1990, and was President,  Director and Chief
Executive Officer of BankAmerica  Corporation from 1981 to 1986. Mr. Armacost is
a member of the Board of Directors of Chevron Corporation and Exponent,  Inc. In
addition,  Mr.  Armacost  is on the  Board  of  Directors  of the  James  Irvine
Foundation and the Advisory Board of the California Academy of Sciences,  and he
is a member of the International  Advisory Group for Toshiba Corporation and The
Business Council.

         Mr.  Brewer is President  and Chief  Executive  Officer of Scios Inc.
He joined  Scios in  September  1998 and has served as a Director  since that
time.  From early 1996 to 1998, he was with  Heartport  Inc.,  first as
Executive Vice President of Operations and then,  Chief Operating  Officer.
Prior to that, Mr. Brewer served in various  capacities with Genentech,  Inc.
from 1984 to 1995, most recently as Senior Vice President,  U.S. Sales and
Marketing,  Genentech  Europe Ltd., and Genentech  Canada,  Inc. Mr. Brewer
earned a B.S. from Virginia Polytechnic Institute and a M.B.A. from Northwestern
University.

         Dr. Rice was  elected  Chairman of the Board in November 1998 and has
served as a Director of Scios since  August  1997.  Dr.Rice is the President,
Chief Executive Officer and Director of UroGenesys,  Inc.  Previously,  he
served Teledyne,  Inc. as President, Chief  Operating  Officer and Director
from 1993 to 1996,  the U.S. Department of Defense as Secretary of the Air
Force from 1989 to 1993,  and The RAND  Corporation  as President and Chief
Executive  Officer from 1972 to 1989. He was also  Assistant  Director of the
Office of  Management  and Budget, The White House.  Dr. Rice is a member of the
Board of  Directors of Wells Fargo & Company,  Vulcan Materials Company and
Unocal Corporation.

         Dr. Sanders was elected a Director of Scios in September  1997. He
served as Chief  Executive  Officer of Glaxo Inc. from 1989 to 1994, and was
Chairman of the Board from 1992 to 1995.  He also served on the Board of
Directors  of Glaxo plc.  Previously,  he held a number of  positions  at Squibb
Corporation,  a  multinational  pharmaceutical  corporation,  including  Vice
Chairman,  Chief Executive  Officer of the Science and Technology  Group and
Chairman of the Science and Technology  Committee of the Board. Dr. Sanders
is a member of the Board of Directors of Magainin  Pharmaceuticals,  Vertex
Pharmaceuticals,  Staff Mark, Inc., Kendle  International, Trimeris,
Pharmacopeia, Genentech, Inc. and Biopure.

         Dr.  Snyder was  elected a Director  in  September  1992.  Dr.  Snyder
is  Director  of the  Department  of  Neuroscience  and Distinguished  Service
Professor of Neuroscience,  Pharmacology and Molecular Sciences and Psychiatry
at The Johns Hopkins  University, and has been a member of the faculty there
since 1966. Dr. Snyder  received the Albert Lasker Award for Basic  Biomedical
Research and Honorary Doctor of Science degrees from Northwestern University,
Georgetown University and Ben Gurion University.  Dr. Snyder received
the Wolfe Award in Medicine from the  government of Israel for research relating
to receptors.  Dr. Snyder is a member of the National Academy of Sciences and a
Fellow of the American Academy of Arts and Sciences.  Dr. Snyder is also the
author of numerous articles and several books. Dr. Snyder is a founder and a
director of Guilford Pharmaceuticals Inc.

         Dr. Sobel was elected a Director in February 1996. Dr. Sobel is
Physician-in-Chief,  E.L.  Amidon  Professor and Chair of the Department of
Medicine at The  University  of Vermont  College of Medicine.  Previously,  Dr.
Sobel was Professor of Medicine at Barnes Hospital,  Washington  University  and
Director of its  Cardiovascular  Division.  Dr.  Sobel has been a  consultant to
and served on scientific advisory boards of several pharmaceutical and
biotechnology  companies,  and served as a director of Squibb Corporation from
1986 to 1989. Dr. Sobel has been the recipient of numerous awards, including the
American Heart Association's  James B. Herrick Award and its Scientific
Council's Distinguished  Achievement Award, as well as the American College of
Cardiology's  Distinguished Scientist Award.  Dr.  Sobel has been the  editor of
Circulation  and,  since  1989,  has  served as editor  of  Coronary  Artery
Disease.  His memberships  and  fellowships  include the American  College of
Physicians,  Royal Society of Medicine,  American  Heart  Association,
American College of Cardiology and Fellowship and Council membership in the
American Association for the Advancement of Science.

         Mr. Step was elected a Director in February 1993.  From May 1956 until
he retired in  December 1992,  Mr. Step was employed by Eli Lilly and Company,
most recently as Executive Vice President,  President of the Pharmaceutical


<PAGE>

Division,  where he was responsible for U.S. pharmaceutical  operations and for
the  operations of Eli Lilly  International.  In addition,  Mr. Step served on
Eli Lilly's Board of Directors  and  executive  committee.  Mr. Step was
Chairman of the Board of  Directors  of the  Pharmaceutical  Manufacturers
Association and President of the International  Federation of Pharmaceutical
Manufacturers  Associations.  He is a member of the Board of Directors of Cell
Genesys Inc., Guidant Corporation, Medco Research Inc., Pathogenesis
Corporation and DBT Online Inc.

         In accordance with his longstanding  personal plans, Myron Du Bain (age
76), a director of the Company  since 1989,  will retire from the Board upon the
election  of the new  slate  of  directors  at the  Annual  Meeting.  The  Board
sincerely  thanks Mr. Du Bain for the guidance and wisdom he has provided to the
Company.

                  INFORMATION ABOUT THE BOARD OF DIRECTORS AND
                             COMMITTEES OF THE BOARD

Compensation of Directors

         General.

         Fees.  Directors who are not otherwise  employed by the Company receive
an annual  retainer  of $8,000  and a fee of $1,000  per day for  attendance  at
meetings  of the  Board  of  Directors  or  committee  meetings,  and  $500  for
attendance   at  a  telephonic   meeting.   Directors   are  also  eligible  for
reimbursement  of  expenses  incurred in  connection  with  attendance  at Board
meetings in accordance with Company policy.

         Stock  Options.  In May 1998, the  stockholders  of the Company
approved an amendment of the Company's 1992 Equity  Incentive Plan (the "Equity
Plan") to provide that each non-employee Director shall automatically be
granted,  at each annual meeting where the Director is elected to the Company's
Board, a supplemental  stock option to purchase 10,000 shares of the Company's
Common Stock.  Such options are granted with exercise prices equal to the
current full market price.  Only  non-employee  Directors of the Company are
eligible to receive options under the applicable  provisions of the Equity Plan,
and Mr. Armacost,  Mr. Du Bain, Dr. Rice, Dr. Sanders, Dr. Snyder, Dr. Sobel
and Mr. Step each received an automatic option grant at the time of re-election
to the Board in May 1999.

         Board of  Directors.  During  1999, there were [12] meetings of the
Board of  Directors  and [9] meetings of the various committees.

         Chairman  of the  Board.  On  November  9,  1999,  Donald  B.  Rice was
re-elected  Chairman of the Board, a nonexecutive  position,  and for serving in
this role the Board awarded Dr. Rice additional cash  compensation of $7,500 per
quarter  and a  supplemental  stock  option  to  purchase  15,000  shares of the
Company's Common Stock at the then current market price.

         Audit Committee. The Audit Committee consists of four non-employee
Directors:  Mr. Step (Chairman),  Mr. Armacost, Dr. Sanders and Dr. Sobel.  The
Audit Committee met four times in 1999.  Among the committee's functions are
recommending engagement of the Company's  independent auditors, approving
services performed by such auditors, and reviewing and evaluating the Company's
accounting systems and its system of internal accounting controls.

         Management  Development and Compensation  Committee.  The Management
Development and Compensation Committee consists of five non-employee Directors:
Mr. Armacost (Chairman), Mr. Du Bain, Dr. Rice,  Dr. Sanders and Mr. Step.  The
committee met four times during 1999.  Among the committee's functions are
establishing the Company's compensation programs for all employees, fixing the
compensation levels of executive officers of the Company, and administering and
making awards under the Company's incentive programs.

         Nominating  Committee.  The Nominating Committee consists of three
non-employee Directors: Mr. Du Bain (Chairman),  Dr. Rice and Dr. Snyder.  The
committee met one time in fiscal 1999. Among the committee's  functions are
recommending  nominees to serve on the Board of  Directors, recommending  the
size and composition of the Board, making recommendations concerning membership
of Board committees and Director compensation, and consulting with the Board of
Directors and management to determine criteria for nominations.  The Nominating
Committee will consider nominees recommended by stockholders.

<PAGE>

         In [1999], all Directors attended at least 75% of the meetings of the
Board and  Committees of the Board of which they were members.

           SECURITY OWNERSHIP OF MANAGEMENT AND PRINCIPAL STOCKHOLDERS

                              Beneficial Ownership

         The  following  table  sets forth  certain  information  regarding  the
beneficial  ownership of the Company's Common Stock at December 31, 1999, by (i)
all persons known by the Company to be beneficial  owners of more than 5% of its
Common Stock, (ii) each Director,  (iii) each of the executive officers named in
the  Summary  Compensation  Table  included  herein and (iv) all  Directors  and
executive officers of the Company as a group.

<TABLE>
<CAPTION>
                                                              Beneficial Ownership(1)
                                                              -----------------------

                                                       Beneficially                  Approximate
Officers, Directors &                                  Owned                         Percent
5% Stockholders                                        Shares(2)                     of Class
- ---------------------                                  ------------                  -----------
<S>                                                   <C>                            <C>

Samuel H. Armacost                                        60,500                        *
Richard B. Brewer                                        280,000                        *
Myron Du Bain                                             63,500(3)                     *
Donald B. Rice, Ph.D.                                     66,250                        *
Charles A. Sanders, M.D.                                  27,166                        *
Solomon H. Snyder, M.D.                                   42,333                        *
Burton E. Sobel, M.D.                                     33,500                        *
Eugene L. Step                                            42,500                        *
Elliott B. Grossbard, M.D.                               291,865                        *
David W. Gryska                                           69,166                        *
John H. Newman                                           272,173(3)                     *
John A. Lewicki, Ph.D.                                   220,773                        *

All officers and directors as a
  group (13 persons)                                    1,469,726                     [_____]%

Randal J. Kirk(4)
  Third Security LLC
  The Governor Tyler
  Radford, VA  24141                                   2,000,000                      [     ]%
- ---------
<FN>
* less than 1%

(1)      Unless  otherwise  indicated  below and subject to  community  property
         laws,  each  stockholder  has sole  voting  and  investment  power with
         respect to the shares beneficially owned.

(2)      For Mr.  Armacost,  Mr. Brewer,  Mr. Du Bain, Dr. Rice, Dr.  Sanders,
         Dr. Snyder, Dr. Sobel, Mr. Step, Dr. Grossbard,  Mr. Gryska, Mr.
         Newman, Dr. Lewicki,  and all officers and directors as a group,
         includes  35,500; 180,000; 33,500; 46,250; 27,166; 22,333; 33,500;
         41,500; 284,081; 29,166; 178,123; 204,872; and 1,115,991 shares,
         respectively, issuable upon exercise of outstanding options exercisable
         within sixty days of December 31, 1999.

(3)      With respect to Mr. Du Bain, includes 25,000 shares held in a revocable
         living  trust for the benefit of Mr. Du Bain and his wife;  Mr. Du Bain
         is a trustee of such trust. With respect to Mr. Newman,  includes 7,000
         shares held in his  spouse's  IRA account and 2,000 shares held for the
         benefit of Mr. Newman's children.

<PAGE>

(4)      Based solely on  information  contained in a Schedule 13D dated July 3,
         1999, and includes 387,000 shares reported to be beneficially  owned by
         RJK, LLC, 225,000 shares reported to be beneficially owned by Kirkfield
         L.L.C.,  and 251,400 shares  reported to be  beneficially  owned by the
         Kirk Family Investment Plan.
</FN>
</TABLE>

         There are no  family  relationships  between  any of the  Directors  or
executive  officers of the  Company.  The  Company is not aware of any  material
proceeding  to which any  Director  or  executive  officer of the Company or any
associate of any such  Director or executive  officer is a party  adverse to the
Company or any of its  subsidiaries  or has a material  interest  adverse to the
Company or any of its subsidiaries.

Compliance with Section 16(a) of the Exchange Act

         Section 16(a) of the  Securities  Exchange Act of 1934, as amended (the
"Exchange  Act"),  requires  the  Company's  Directors,  executive  officers and
holders of more than ten  percent  (10%) of the  Company's  Common  Stock  ("10%
Holders")  to file with the  Securities  and  Exchange  Commission  (the  "SEC")
initial reports of ownership and reports of changes in ownership of Common Stock
and other equity securities of the Company.  Directors,  executive  officers and
10% Holders are required by SEC regulation to furnish the Company with copies of
all Section 16(a) forms they file.

         Based solely on its review of the copies of such forms  received by it,
or written  representations  from certain reporting persons that no Forms 5 were
required for those persons,  the Company believes that during 1999 its officers,
directors  and greater  than ten percent  beneficial  owners  complied  with all
applicable filing requirements.


<PAGE>



                             EXECUTIVE COMPENSATION

         The following  table discloses  compensation  received by the Company's
Chief  Executive  Officers  and each of its four other most  highly  compensated
executive  officers at December 31, 1999 for the fiscal years ended December 31,
1999, 1998 and 1997.

<TABLE>
<CAPTION>

                                                      SUMMARY COMPENSATION TABLE

                                                                           Long-Term
                                                                           Compensation
                                      Annual Compensation                  Awards
                                   ------------------------                -------------------

Name                                                                                      Securities
and                                                                        Restricted     Underlying     All Other
Principal                                                                  Stock          Stock          Compensa-
Position                      Year      Salary ($)     Bonus (1)($)        Award (2)($)   Options(#)     sation (3)($)
- --------                      ----      ----------     ------------        ------------    ----------    -------------
<S>                          <C>       <C>            <C>                 <C>            <C>            <C>


Richard B. Brewer             1999      $400,000            *                 --          200,000           *
  President and Chief         1998      $103,000(4)    $ 50,000            $596,775       275,000        $3,000
  Executive Officer           1997        N/A

Elliott B. Grossbard, M.D.    1999      $270,000            *                 --           40,000           *
  Senior Vice President       1998      $260,000       $100,000               --           68,500        $3,000
  of Development              1997      $246,064           --                 --           19,000        $3,000

David W. Gryska               1999      $195,000             *             $152,460          --             *
  Vice President of Finance   1998      $  8,860(5)    $  5,000               --          100,000           *
   and Chief Financial Officer1997          N/A

John A. Lewicki, Ph.D.        1999      $230,000             *                --           20,000           *
   Vice President             1998      $222,000       $ 50,000               --           50,000        $3,000
   of Research                1997      $222,000            --                --           12,000        $3,000

John H. Newman                1999      $228,000             *                --           20,000           *
  Senior Vice President,      1998      $220,000       $ 50,000               --           53,500        $3,000
  General Counsel &           1997      $212,500            --                --           19,000        $3,000
  Secretary

<FN>
*  [Not yet determined.  1999 compensation decisions will be made by the
Company's Management Development and Compensation Committee
shortly after the fiscal year end and prior to mailing.]
- ---------------
(1)   Bonus amounts  represent the value of awards under the Company's  Employee
      Incentive  Plan.  Awards  to  executive   officers  under  this  plan  are
      determined  annually  by  the  Management   Development  and  Compensation
      Committee.

(2)   Mr.  Brewer  received  100,000  shares of Common Stock valued on the grant
      date at $5.96875 per share upon  becoming  President  and Chief  Executive
      Officer  (See  Note 4).  50% of the  shares vested on the first
      anniversary of his employment (September 9, 1999) triggering an income tax
      withholding obligation of $73,206.25 which Mr. Brewer has paid and 50% of
      the shares will vest on the second  anniversary of his employment with a
      similar tax obligation due from Mr. Brewer at that time.  The aggregate
      value of such shares on December 31, 1999 was $_______________.  Mr.
      Gryska, the Company's Vice President of Finance and Chief Financial
      Officer, received 40,000 shares of Common Stock valued on the grant date
      at $3.8125 per share.  25% of the shares  vest on August 9, 2000 and 75%
      of the shares vest on August 9, 2002.  The aggregate value of such shares
      on December 31, 1999 was $______________.  No dividends will be paid by
      the Company with respect to the restricted stock awards.

<PAGE>

(3)   Consists of Company matching contributions under the 401(k) Profit Sharing
      Plan and Trust,  which was  established  in 1986. As of December 31, 1999,
      the  Company  made   matching   contributions   of  100%  of   participant
      contributions,  up to a maximum of $3,000 per  participant  per plan year.
      Employee  contributions  are at  all  times  100%  vested.  The  Company's
      contributions  vest based on years of service:  0% for less than one year;
      25% for one but less  than two  years;  50% for two but  less  than  three
      years;  and 100% for  three or more  years.  Federal  tax laws  impose  an
      overall limit on the amount that may be contributed by  participants  each
      year under 401(k) plans.

(4)   Mr. Brewer became President and Chief Executive Officer of the Company at
      an annual salary of $400,000 in September 1998.

(5)   Mr. Gryska became Vice President of Finance and Chief Financial Officer of
      the Company at an annual salary of $195,000 in December 1998.

</FN>
</TABLE>


                        Stock Option Grants and Exercises

      In the  Company's  efforts  to  recruit  the best  available  talent  in a
competitive  labor market,  the Company  grants stock options to provide  equity
incentives. The Company currently grants stock options under the 1992 Equity and
Incentive Plan and the 1996 Non-Officer Stock Option Plan.

      The following table provides certain  information on stock options granted
to the executive officers named in the Summary Compensation Table, in the fiscal
year ended December 31, 1999.  The Company did not grant any stock  appreciation
rights in the fiscal year ended December 31, 1999.

<TABLE>
<CAPTION>

                                          Option Grants in Last Fiscal Year

                                                                                     Potential Realizable Value at
                                                                                     Assumed Annual Rates of Stock
                                            Individual Grants                        Price Appreciation for Option Term(1)
- --------------------------------------------------------------------------------     -------------------------------------

                No. of             % of Total
                Securities         Options              Exercise
                Underlying         Granted to           or Base
                Options            Employees in        Price         Expiration
Name            Granted(2)(#)      Fiscal Year         ($/Sh)(2)     Date            0%($)    5%($)      10%($)
- ----            -------------      -----------          ---------     --------        -----    -----      ------
<S>            <C>                 <C>                <C>            <C>             C>       <C>       <C>


R. Brewer       200,000(3)          9.83               $4.09          05/02/09         0       $514,907  $1,304,877
E. Grossbard     40,000(4)          1.97               $8.75          02/08/09         0       $220,113  $  557,810
D. Gryska           -0-              --                  --             --            --        --             --
J. Lewicki       20,000(4)          0.98               $8.75          02/08/09         0       $110,057  $  278,905
J. Newman        20,000(4)          0.98               $8.75          02/08/09         0       $110,057  $  278,905
- ---------
<FN>

(1)  The potential realizable value is based on the assumption that the price of
     the Common Stock appreciates at the annual rate shown, compounded annually,
     from the date of grant  until  the end of the  ten-year  option  term.  The
     numbers are calculated based on requirements  promulgated by the Securities
     and Exchange  Commission,  which did not reflect the Company's  estimate of
     future stock price growth.

(2)  See  "Management   Development  and  Compensation   Committee  Report"  for
     additional  information  on these stock  options.  All grants in this table
     were made  pursuant  to the 1992  Equity  Incentive  Plan.  All options are
     granted at fair market value on the date of grant.

(3)  This option vests in 4 annual installments commencing on May 3, 1999
     and ending on May 3, 2002.

<PAGE>

(4)  75% of these options vest in monthly installments commencing on January 1,
     1999 and ending on December 31, 2001; 25% vest in monthly installments
     commencing January 1, 2002 and ending on December 31, 2002.
</FN>
</TABLE>


         The  following  table sets forth  certain  information  with respect to
options  exercised  and  options  held at  December  31,  1999 by the  executive
officers named on the Summary Compensation Table.

<TABLE>
<CAPTION>

                 Aggregated Option Exercises in Last Fiscal Year
                            and FY-End Option Values

                                                                                               Value of Unexercised,
                    Shares                        Number of Securities Underlying              In-the-Money Options
                    Acquired on     Value         Unexercised Options at FY-End                at FY-End
Name                Exercise(#)     Realized($)   Exercisable(#) Unexercisable(#)     Exercisable(1)($) Unexercisable(1)($)
- ----                -----------     -----------   -------------- ----------------     ----------------- -------------------
<S>                 <C>           <C>            <C>            <C>                 <C>                 <C>


R. Brewer             0              0            180,000        295,000             $_________          $___________

E. Grossbard         1,500         $7,031         277,750         76,625             $_________          $___________

D. Gryska             0              0             25,000         75,000             $_________          $___________

J. Lewicki            0              0            200,000         57,250             $_________          $___________

J. Newman             0              0            173,250         54,125             $_________          $___________


- ---------
<FN>

(1)      Based on the amount,  if any, by which the market value of the
         Company's Common Stock at December 31, 1999 ($_____)  exceeds the
         exercise price of the options.
</FN>
</TABLE>

                       EMPLOYMENT AND SEVERANCE AGREEMENTS

         See "Management  Development and Compensation  Committee Report - Chief
Executive  Officer  Compensation"  for a description of Mr. Brewer's  employment
agreement.


           MANAGEMENT DEVELOPMENT AND COMPENSATION COMMITTEE REPORT(1)

         The  Management  Development  and  Compensation  Committee of the
Board of Directors (the  "Committee") is responsible for establishing  the
Company's compensation  programs for all employees, including  executives.  For
executive officers, the Committee evaluates performance and determines specific
compensation  policies and levels. In 1999, the Committee was composed of Mr.
Armacost, Mr. Du Bain, Dr. Rice, Dr. Sanders and Mr. Step.  None of these
directors were officers or employees of the Company.

Compensation Philosophy

         The goals of the  compensation  program are to link  compensation  with
business  objectives  and  performance,  and to enable the  Company to  attract,
retain and reward  executive  officers and other key employees who contribute to
the long-term success of the Company and to build long-term  stockholder  value
Key elements of this philosophy are:

___________________
1 The material in this report and the chart on page 13 is not "Soliciting
Material", is not deemed "filed" under the Securities Act of 1934, as
amended, or the Exchange Act and is not to be incorporated by reference into
any filing of the Company whether made before or after the date hereof,
regardless of any general incorporation language in such filing.

<PAGE>

o        The Company pays  competitively  with leading  biotechnology  and other
         companies  with which the Company  competes for  management or employee
         talent.  To  ensure  that pay is  competitive,  the  Company  regularly
         compares  its  pay  practices   with  these   companies  and  sets  its
         compensation parameters based on this review.

o        The Company  maintains  annual  incentive  opportunities  sufficient to
         provide  motivation to achieve specific  business goals and to generate
         rewards that bring total compensation to competitive levels.

o        The Company provides significant equity-based incentives for executives
         and other key  employees  to ensure  that they are  motivated  over the
         long-term to respond to the Company's business challenges and strategic
         opportunities as owners as well as employees.

         The primary  components  of  executive  compensation  are base  salary,
annual incentives and long-term equity incentives. Over the last five years, the
Committee  has not  granted a salary  increase  to the CEO and has only  granted
modest or no salary  increases  over the last three  years to other  executives.
These actions reflect the Committee's intent to lower the relative percentage of
fixed compensation and increase the relative  percentage of pay at risk based on
performance.

         The  Committee's  objective  in  general  is to set each  component  of
executive  compensation  at the market  average  when  compared to a  nationwide
survey of the  biotechnology  industry (the  "comparator  group").  In 1999, the
comparator group contained approximately 300 companies. Many of the companies in
the  comparator  group are included in the  Performance  Graph  included in this
Proxy Statement.

         Base Salary.  The Committee  annually reviews each executive  officer's
base salary  against the base salaries  paid for similar  positions by companies
within the  comparator  group.  A range of salary levels is  established by this
comparison  targeted at the 50th  percentile  salary for  comparable  positions.
Within this range,  the Committee  subjectively  considers  individual  factors,
including individual performance, level of responsibility,  prior experience and
breadth of  knowledge,  as well as  competitive  pay practices and the extent to
which the Company  achieved its  corporate  objectives  described in the section
below entitled Annual  Incentive.  From year to year, the relative  weighting of
the  individual  components and the corporate  performance  component may differ
from officer to officer,  and can be expected to change over time in response to
the Company's evolution.

         Annual  Incentive.  The Employee  Incentive Plan, an annual award plan,
offers variable pay for officers and other employees of the Company based on the
extent to which Company and individual  performance  objectives are achieved. At
the start of each year, the Committee and the full Board of Directors review and
approve  the  annual  performance  objectives  for the  Company  and  individual
officers.  The Company objectives consist of operating,  strategic and financial
goals that are  considered  to be critical to the  Company's  long-term  goal of
building stockholder value.

         After the end of the year, the Committee  evaluates the degree to which
the Company has met its  objectives  and, at the  discretion  of the  Committee,
establishes  a total  incentive  award pool under the Employee  Incentive  Plan.
Individual awards are determined by evaluating the Company's overall performance
and by evaluating  each  participant's  performance  against  objectives for the
year.  The  incentive  award pool is then  allocated  based on that  assessment.
Awards are paid in cash and  distributions  are made in February  following  the
performance  year.  In lieu  of  making  cash  awards  to  executives  for  1998
performance,  the Committee  elected to distribute  annual  incentive  awards to
executives  in the form of  additional  stock  option  grants  vesting over four
years.

         [1999 decisions of the Management Development and Compensation
Committee to be made after the completion of 1999 and prior to mailing]

         Long-Term  Incentives.  The Company's  long-term  incentive program for
officers  consists of the 1983  Incentive  Stock Option Plan,  (expired March 5,
1993),  the 1986  Supplemental  Stock Option Plan (expired January 16, 1996) and
the 1992 Equity  Incentive  Plan. The option program  utilizes  vesting  periods
(generally  four years) to encourage  key employees to continue in the employ of
the Company  and to look to achieve the  Company's  long-term  strategic  goals.
Through option grants, executives receive significant equity incentives to build
long-term  stockholder  value.   Annually,  the  Committee  reviews  the  equity
incentives  of  executive  officers  and has made  additional  grants  to remain
competitive  with  the  comparator  group  and  maintain  appropriate  long-term
incentives  for key  individuals.  All grants have been made at or above 100% of
fair  market  value on the date of grant.  Executives  receive  value from these
grants only if the

<PAGE>

Company's Common Stock  appreciates  over the long-term.  The
size of option grants generally is determined based on competitive  practices at
companies in the comparator group and the Company's  philosophy of significantly
linking executive  compensation  with stockholder  interests.  In addition,  the
Committee  considers  the terms and  number of  options  previously  awarded  in
determining  the size of option grants.  The Committee  believes the approach of
making  grants that vest over an extended  time  period  creates an  appropriate
focus on longer-term objectives and promotes executive retention.

         Section  162(m) of the Internal  Revenue Code limits the federal income
tax  deductibility of compensation  paid to the Company's CEO and to each of the
other four most highly compensated executive officers.  The Company intends that
the long-term incentive compensation paid to these executives will be deductible
by the  Company  under  Section  162(m).  In 1998,  the Board  and  stockholders
approved  amendments  to the 1992  Equity  Incentive  Plan  intended to meet the
requirements of Section 162(m).

Chief Executive Officer Compensation

         Richard B. Brewer  became the Company's  President and Chief  Executive
Officer  in  September  1998.  Pursuant  to his  employment  agreement  with the
Company,  Mr. Brewer's base salary is $400,000 per annum, subject to increase by
the Board.  Mr. Brewer is also eligible to receive a cash bonus,  at the Board's
discretion,  which bonus will equal 50% of his base  salary if he meets  defined
performance  criteria  and up to a  maximum  of 100% of his base  salary  if his
performance   substantially  exceeds  the  targeted  level;  provided  that  the
guaranteed  minimum level of Mr. Brewer's bonus is $50,000 in 1998,  $200,000 in
1999 and $100,000 in 2000.  Mr. Brewer also received the stock option grants and
restricted stock grant described under "Executive  Compensation." The employment
agreement also provides that if Mr. Brewer's  employment is terminated  "without
cause" or "for good reason" (as defined in the  agreement),  he will receive his
salary for twelve months from termination, an annual bonus for such period equal
to the lesser of his  previous  year's  bonus or his  guaranteed  bonus,  and an
additional two years of vesting on his stock options and restricted  stock. Upon
a "change of control" of the Company (as defined in the agreement),  the vesting
of all of Mr. Brewer's  outstanding  stock options,  restricted shares and share
units will be accelerated.  The Committee believes Mr. Brewer's  compensation is
consistent with the special demands of the position,  the  compensation of chief
executive  officers in the comparator  group and in accord with the compensation
philosophy articulated above. See "Compensation Philosophy-Annual Incentive" and
"Compensation Philosophy-Long-Term Incentive" above.

Conclusion

         In summary, the Compensation Committee believes that, through the plans
and actions described above, a significant portion of the Company's compensation
program and, in particular, the program for executive officers, is contingent on
Company  performance,  and that the realization of benefits is closely linked to
achievement of key corporate objectives that will produce increases in long-term
stockholder  value. The Company remains  committed to this philosophy of pay for
performance,  recognizing that the Company is still in a developmental stage and
that the  competitive  market for talented  executives and the volatility of the
Company's business may result in highly variable compensation for any particular
time  period.  We  will  continue  to  monitor  closely  the  effectiveness  and
appropriateness  of each of the components of compensation to reflect changes in
the Company's business environment.


                                    MANAGEMENT DEVELOPMENT AND
                                    COMPENSATION COMMITTEE

                                    [Signatures of members of committee to be
                                     inserted in a revised filing when report is
                                     complete]


<PAGE>




                                PERFORMANCE GRAPH

         The rules of the  Securities and Exchange  Commission  require that the
Company  include in this Proxy  Statement a  line-graph  presentation  comparing
five-year  stockholder  returns on an indexed basis.  The Company has elected to
use the Russell 2000 Index and the Amex  Biotechnology  Index for the purpose of
the performance  comparison that appears below. The graph assumes the investment
of $100 in the  Company's  Common  Stock,  the  Russell  2000 Index and the Amex
Biotechnology  Index on December 31, 1994. The stock price  performance shown on
the graph below is not necessarily indicative of future price performance.

                 Comparison of Five Year Cumulative Total Return
                    Among Scios Inc., Russell 2000 Index and
                            Amex Biotechnology Index



              [5-year graph to be inserted after December 31, 1999]



<PAGE>



                     CERTAIN RELATIONSHIPS AND TRANSACTIONS

         In 1993, the Company formed Guilford  Pharmaceuticals Inc.
("Guilford").  Dr. Snyder is a director of Guilford. Until March 9, 1999, the
Company owned approximately 7% of the outstanding stock of Guilford.  In March
1999, the Company sold substantially all of its holdings in Guilford, reducing
its ownership to less than 1% of Guilford's outstanding stock.

         In 1998, in connection with the exercise of a stock option, the Company
extended a loan to Mr. Newman in the amount of $137,500. The loan bears interest
at the rate of 5.59% per annum and is  repayable  over four  years.  The current
principal balance is $107,667. Interest has been paid through December 31, 1998.

                                   PROPOSAL 2
                      RATIFICATION OF INDEPENDENT AUDITORS

         Upon  recommendation of the Audit Committee,  the Board of Directors of
the Company appointed PricewaterhouseCoopers LLP to be the Company's independent
auditors for the fiscal year ending December 31, 2000.

         Services   provided   to  the   Company   and   its   subsidiaries   by
PricewaterhouseCoopers  with respect to the fiscal year ended  December 31, 1999
included examination of the Company's consolidated financial statements, limited
reviews of  quarterly  reports,  services  related to filings  with the SEC, and
consultations concerning information systems and various tax matters.

         PricewaterhouseCoopers  has audited the Company's financial  statements
annually   since  the   Company's   inception   in  1982.   Representatives   of
PricewaterhouseCoopers are expected to be present at the Annual Meeting. They do
not  expect  to make a  statement,  but  will  have  the  opportunity  to make a
statement  if  they  desire  to do so  and  will  be  available  to  respond  to
appropriate questions.

         Stockholder ratification of the selection of  PricewaterhouseCoopers as
the Company's  independent  auditors is not required by the Company's  Bylaws or
otherwise.    However,    the   Board   is    submitting    the   selection   of
PricewaterhouseCoopers  to the stockholders for ratification as a matter of good
corporate practice. If the stockholders fail to ratify this selection, the Board
will  reconsider  whether or not to retain that firm.  Even if the  selection is
ratified,  the Board in its discretion may direct the appointment of a different
independent  accounting firm at any time during the year if the Board feels that
such  a  change  would  be  in  the  best  interests  of  the  Company  and  its
stockholders.

         Ratification  of  the  selection  of   PricewaterhouseCoopers   as  the
Company's independent auditors for fiscal year 2000 will require the affirmative
vote of at least a majority of the shares of Common Stock  represented in person
or by proxy and entitled to vote at the Annual Meeting.

      THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL 2.


                                  OTHER MATTERS

         The Board of  Directors  does not know of other  matters  that may come
before the meeting.  However, if any other matters are properly presented to the
meeting,  it is the intention of the persons named in the accompanying  proxy to
vote, or otherwise to act, in accordance with their judgment on such matters.

<PAGE>




                  SHAREHOLDER PROPOSALS FOR 2001 ANNUAL MEETING

         Under the applicable rules of the Securities and Exchange Commission, a
stockholder  who  wishes to  submit a  director  nomination  or a  proposal  for
inclusion  in the proxy  statement  of the  Board of  Directors  for the  annual
meeting  of  stockholders  to be held in the  spring  of 2001 must  submit  such
proposal in writing to the Secretary of the Company at the  Company's  principal
executive offices no later than ____________,  2000. The applicable rules of the
SEC impose certain  limitations on the content of the proposals and also contain
certain  eligibility and other requirements  (including the requirement that the
proponent  must have  continuously  held at least $2000 in market value or 1% of
the  Company's  Common  Stock  for at least  one year  before  the  proposal is
submitted).




                                   By Order of the Board of Directors

                                   JOHN H. NEWMAN
                                   Secretary

____________________, 2000

THE BOARD OF DIRECTORS HOPE THAT STOCKHOLDERS WILL ATTEND THIS MEETING.  WHETHER
OR NOT YOU PLAN TO  ATTEND,  YOU ARE  URGED TO  COMPLETE,  SIGN AND  RETURN  THE
ENCLOSED GOLD PROXY IN THE ACCOMPANYING  ENVELOPE.  THE BOARD OF DIRECTORS URGES
YOU NOT TO SIGN ANY WHITE PROXY SENT TO YOU BY THE KIRK GROUP.  STOCKHOLDERS WHO
ATTEND THE MEETING MAY VOTE THEIR SHARES  PERSONALLY  EVEN THOUGH THEY HAVE SENT
IN THEIR PROXIES.  PLEASE NOTE, HOWEVER,  THAT IF YOUR SHARES ARE HELD OF RECORD
BY A BROKER, BANK OR OTHER NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST
OBTAIN FROM THE RECORD HOLDER A PROXY ISSUED IN YOUR NAME.


<PAGE>

                                   APPENDIX A

  INFORMATION CONCERNING DIRECTORS, EXECUTIVES AND EMPLOYEES OF THE COMPANY WHO
              MAY SOLICIT PROXIES FROM THE COMPANY'S STOCKHOLDERS

Set forth below are the present  principal  occupation  or  employment,  and the
name, principal business and address of any corporation or organization in which
such  employment is carried on, for (1) each of the Company's  directors and (2)
executives  and  employees  of the  Company  who may  solicit  proxies  from the
Company's  stockholders.  Except as otherwise  provided in this Proxy  Statement
(including  the Appendices  hereto),  none of the  individuals  listed below (i)
directly or indirectly  owns any shares of Common Stock or any other  securities
of the Company,  (ii) is, or was within the past year, a party to any contracts,
arrangements or understandings with any person with respect to any securities of
the  Company,  including  but not  limited  to joint  ventures,  loan or  option
arrangements,  puts or calls,  guarantees  against loss or guarantees of profit,
division of losses or profits, or the giving or withholding of proxies, or (iii)
to the  knowledge of the Company,  has,  directly or through an  associate,  any
arrangement or understanding  with any person with respect to future  employment
by the Company or its affiliates or with respect to any future  transactions  to
which  the  Company  or any of its  affiliates  will or may be a party,  nor any
material  interest,  direct or indirect,  in any transaction  which has occurred
since  January  1,  1999 or any  currently  proposed  transaction,  or series of
similar transactions, to which the Company or any of its affiliates was or is to
be a party and in which the amount involved exceeds $60,000.

<TABLE>
<CAPTION>

                                          DIRECTORS, EXECUTIVES AND EMPLOYEES OF THE COMPANY

NAME AND PRINCIPAL                           PRESENT OFFICE OR OTHER
BUSINESS ADDRESS(1)                          PRINICIPAL OCCUPATION OR
                                             OTHER EMPLOYMENT

<S>                                         <C>

Donald B. Rice, Ph.D.                        Chairman of the Board President and Chief Executive Officer of
Urogenesys, Inc.                             Urogenesys, Inc.
1701 Colorado Avenue
Santa Monica, CA  90404-3436

Richard B. Brewer                            President and Chief Executive Officer

Samuel H. Armacost                           Chairman, SRI International
SRI International
333 Ravenswood Avenue
Menlo Park, CA  94025

Myron Du Bain                                Chairman and Chief Executive Officer (Retired),
Bay Isle Financial Corporation               Firemen's Fund Corporation
160 Sansome, 17th floor
San Francisco, CA  94014

Charles A. Sanders, M.D.                     Chairman and Chief Executive Officer (Retired), Glaxo, Inc.
Europa Center
100 Europa Drive, Suite 170
Chapel Hill, NC  27514


<PAGE>

Solomon H. Snyder, M.D.                      Director, Department of Neuroscience,
The John Hopkins University                  Distinguished Service Professor of Neuroscience, Pharmacology and
School of Medicine                           Molecular Sciences and Psychiatry, The John Hopkins University
Department of Neuroscience
725 No. Wolfe Street
Baltimore, MD  21205

Burton E. Sobel, M.D.                        E.L. Amidon Professor and Chair, Department of Medicine,
The University of Vermont                    The University of Vermont
College of Medicine
Fletcher House/MCHV
111 Colchester Avenue
Burlington, VT  05401

Eugene L. Step                               Executive Vice President, President of the Pharmaceutical Division
P.O. Box 8997                                (Retired), Eli Lilly Company
Rancho Santa Fe, CA  92067

Thomas L. Feldman                            Vice President of Sales and Marketing

Elliott B. Grossbard, M.D.                   Senior Vice President of Development

David W. Gryska                              Vice President of Finance and Chief Financial Officer

John A. Lewicki, Ph.D.                       Vice President of Research

John H. Newman                               Senior Vice President, General Counsel & Secretary

George F. Schreiner, M.D., Ph.D.             Vice President, Cardiorenal Research

Wendy Carhart                                Senior Manager of Investor Relations

<FN>

(1)       The principal business address of each executive officer and employee
          of the Company is 820 West Maude Avenue, Sunnyvale, California  94086.
</FN>
</TABLE>




<PAGE>



                                   APPENDIX B

     SHARES OF COMMON STOCK HELD BY THE COMPANY'S DIRECTORS, EXECUTIVES AND
      EMPLOYEES WHO MAY SOLICIT PROXIES, AND CERTAIN TRANSACTIONS BETWEEN
                           ANY OF THEM AND THE COMPANY

         Dr.  Rice  beneficially  owns  66,250  shares of Company  Common  Stock
 (including 46,250 shares subject to stock options exercisable within 60 days of
 December 31, 1999).

         Mr. Brewer  beneficially  owns 280,000  shares of Company  Common Stock
 (including  180,000 shares subject to stock options  exercisable within 60 days
 of December 31, 1999).

         Mr.  Armacost  beneficially  owns 60,500 shares of Company Common Stock
 (including 35,500 shares subject to stock options exercisable within 60 days of
 December 31, 1999).

         Mr. Du Bain  beneficially  owns 63,500  shares of Company  Common Stock
 (including 33,500 shares subject to stock options exercisable within 60 days of
 December  31, 1999 and 25,000  shares held in a revocable  living trust for the
 benefit of Mr. Du Bain and his wife; Mr. Du Bain is a trustee of such trust).

         Dr.  Sanders  beneficially  owns 27,166 shares of Company  Common Stock
 (all of which  are  subject  to stock  options  exercisable  within  60 days of
 December 31, 1999).

         Dr.  Snyder  beneficially  owns 42,333  shares of Company  Common Stock
(including  22,333  shares  subject to stock  options exercisable within 60 days
of December 31, 1999). In 1993, the Company formed Guilford  Pharmaceuticals
Inc. ("Guilford").  Dr. Snyder is a director of Guilford.  Until March 9, 1999,
the Company owned  approximately  7% of the  outstanding  stock of Guilford.
In March 1999, the Company sold substantially all of its holdings in Guilford,
reducing  its  ownership  to less than 1% of  Guilford's outstanding stock.

         Dr. Sobel  beneficially owns 33,500 shares of Company Common Stock (all
of which are subject to stock options exercisable within 60 days of December 31,
1999).

         Mr.  Step  beneficially  owns  42,500  shares of Company  Common  Stock
 (including 41,500 shares subject to stock options exercisable within 60 days of
 December 31, 1999).

         Mr.  Feldman  beneficially  owns 107,260 shares of Company Common Stock
(including 104,560 shares subject to stock options exercisable within 60 days of
December 31,  1999).  In 1995,  Mr.  Feldman  received a relocation  loan in the
amount of $275,000 to assist in his move to  California as part of the Company's
decision to bring the management offices for its commercial  operations division
to the  Company's  headquarters.  The  loan is  being  forgiven  over 5 years of
employment. $110,000 was outstanding under the loan as of December 31, 1999.

         Dr. Grossbard  beneficially owns 291,865 shares of Company Common Stock
 (including  284,081 shares subject to stock options  exercisable within 60 days
 of December 31, 1999).

         Mr.  Gryska  beneficially  owns 69,166  shares of Company  Common Stock
 (including 29,166 shares subject to stock options exercisable within 60 days of
 December 31, 1999).

         Mr.  Lewicki  beneficially  owns 220,773 shares of Company Common Stock
 (including  204,872 shares subject to stock options  exercisable within 60 days
 of December 31, 1999).

<PAGE>

         Mr. Newman  beneficially  owns 272,173  shares of Company  Common Stock
(including 178,123 shares subject to stock options exercisable within 60 days of
December 31, 1999,  7,000 shares held in Mr.  Newman's  spouse's IRA account and
2,000  shares  held for the  benefit  of Mr.  Newman's  children).  In 1998,  in
connection with the exercise of a stock option,  the Company  extended a loan to
Mr.  Newman in the amount of  $137,500.  The loan bears  interest at the rate of
5.59% per annum and is repayable over four years. The current  principal balance
is $107,667. Interest has been paid through December 31, 1998.

         Dr. Schreiner beneficially owns 69,925 shares of Company Common Stock ,
 all of  which  are  subject  to stock  options  exercisable  within  60 days of
 December 31, 1999).

         Ms. Carhart does not beneficially own any shares of Company Common
Stock.


             TRANSACTIONS IN COMMON STOCK WITHIN THE PAST TWO YEARS

 Listed below are the only  purchases  and sales of Company  Common Stock within
 the past two years by the  directors,  executives  and employees of the Company
 who may  solicit  proxies on the  Company's  behalf,  and  certain  information
 concerning  such  transactions.   To  the  Company's  knowledge,  no  director,
 executive or employee who may solicit proxies on the Company's  behalf made any
 other transactions in Company securities within the past two years.

<TABLE>
<CAPTION>

Name                                         Number of Shares Purchased/        Date of Transaction
                                             (Sold)
<S>                                         <C>                                <C>

Donald B. Rice, Ph.D.                          2,000                            09/17/98
                                               8,000                            10/16/98

Richard B. Brewer                            100,000 (1)                        09/09/98

Samuel H. Armacost                               0                              --

Myron Du Bain                                    0                              --

Charles A. Sanders, M.D.                         0                               --

Solomon H. Snyder, M.D.                        10,000                           10/27/98

Burton E. Sobel, M.D.                             0                             --

Eugene L. Step                                    0                             --

Thomas L. Feldman                                 0                             --

Elliott B. Grossbard, M.D.                      2,000                           10/09/98
                                                1,500 (2)                       01/07/99
                                               (1,500)(2)                       01/07/99
                                                1,500                           12/14/99

David W. Gryska                                40,000 (1)                       08/09/99

John A. Lewicki, M.D.                          20,000 (2)                       02/20/98
                                              (20,000)(2)                       02/20/98
                                               20,000 (2)                       02/23/98
                                              (20,000)(2)                       02/23/98


<PAGE>

John H. Newman                                  20,000 (3)(4)                   03/03/98
                                                 5,000 (2)                      03/06/98
                                                (5,000)(2)                      03/06/98
                                                 5,000 (2)                      03/09/98
                                                (5,000)(2)                      03/09/98
                                                 5,000 (3)(4)                   03/10/98
                                                 5,000 (2)                      03/10/98
                                                (5,000)(2)                      03/10/98
                                                 5,000                          09/16/98
                                                 2,000                          10/08/98

George F. Schreiner, M.D., Ph.D.                   0                            --

Wendy Carhart                                      0                            --

<FN>

(1)      Shares purchased in the form of a Restricted Stock Award.
(2)      Shares purchased through exercise of stock options and sold in the same
         day.
(3)      Shares purchased through exercise of stock options.
(4)      The Company extended a loan to Mr. Newman for a portion of the purchase
         price of these shares.  The loan is described above under Mr. Newman's
         beneficial ownership.
</FN>
</TABLE>


<PAGE>


 SCIOS INC. PROXY SOLICITED BY THE BOARD OF DIRECTORS FOR THE ANNUAL MEETING OF
                   STOCKHOLDERS TO BE HELD FEBRUARY 28, 2000


DETACH HERE

SCIOS INC. ANNUAL MEETING TO BE HELD ON FEBRUARY 28, 2000 AT __:__ _.m.

PLEASE MARK/ X / VOTES AS IN THIS EXAMPLE

THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR PROPOSALS 1 AND 2.

1.   Election of Directors.
     NOMINEES: 01- Samuel H. Armacost, 02- Richard B. Brewer,
     03 -Donald B. Rice, 04- Charles A. Sanders, 05- Solomon H. Snyder,
     06- Burton E. Sobel, 07- Eugene L. Step,

FOR ALL NOMINEES  /     /
WITHHOLD ALL NOMINEES /   /
For all nominees except as noted below
Use Number Only

2. To  ratify  the  selection  of  PricewaterhouseCoopers  LLP as the  Company's
Independent auditors for fiscal 2000.

FOR  /     /   AGAINST /     /  ABSTAIN /   /

MARK HERE IF YOU PLAN TO ATTEND THE MEETING /  /
MARK HERE FOR ADDRESS CHANGE AND NOTE BELOW /

(Please sign  exactly as name  appears.  When shares are held by joint  tenants,
both should sign. When signing as attorney, as executor, administrator,  trustee
or guardian,  please give full title as such. If a  corporation,  please sign in
full corporate name by President or other authorized  officer. If a partnership,
please sign in partnership name by authorized person.)



Signature:______________________________________  Date:__________________


Signature:______________________________________  Date:__________________


<PAGE>




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