SCIOS INC
DEF 14A, 1999-04-05
PHARMACEUTICAL PREPARATIONS
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                            SCHEDULE 14A INFORMATION

                  Proxy Statement Pursant to Section 14(a) of
              the Securities Exchange Act of 1934 (Amendment No. )

Filed by the Registrant /X/
Filed by a Party other than the Registrant / /

Check the appropriate box:
/ /  Preliminary Proxy Statement
/ /  Confidential, for Use of the Commission Only (as permitted by Rule
          14a-6(e) (2))
/X/  Definitive Proxy Statement
/ /  Definitive Additional Materials
/ /  Soliciting Material Pursuant to Section 240.14a-11(c) or
          Section 240.14a-12

                                   SCIOS INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
- --------------------------------------------------------------------------------
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

/X/  No fee required.
/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
     1)   Title of each class of securities to which transaction applies:
          ----------------------------------------------------------------------
     2)   Aggregate number of securities to which transaction applies:
          ----------------------------------------------------------------------
     3)   Per unit price or other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
          filing fee is calculated and state how it was determined):
          ----------------------------------------------------------------------
     4)   Proposed maximum aggregate value of transaction:
          ----------------------------------------------------------------------
     5)   Total fee paid:
          ----------------------------------------------------------------------
/ /  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously.  Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.
     1)   Amount Previously Paid:
          ----------------------------------------------------------------------
     2)   Form, Schedule or Registration Statement No.:
          ----------------------------------------------------------------------
     3)   Filing Party:
          ----------------------------------------------------------------------
     4)   Date Filed:
          ----------------------------------------------------------------------

<PAGE>

                                     [LOGO]


                                   Scios Inc.
                              2450 Bayshore Parkway
                         Mountain View, California 94043

                                   ----------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                              Tuesday, May 11, 1999
                                    8:30 a.m.
                                   ----------

To the Stockholders:

         NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of Scios
Inc., a Delaware  corporation  (the  "Company"),  will be held at the  Company's
principal executive offices,  2450 Bayshore Parkway,  Mountain View,  California
94043,  at 8:30 a.m.  on Tuesday,  May 11,  1999,  to consider  and act upon the
following matters:

         (1)   To  elect  directors of the Company to serve for the ensuing year
               and until their successors are elected.

         (2)   To  ratify  the  selection of  PricewaterhouseCoopers  LLP as the
               Company's independent auditors for fiscal 1999.

         (3)   To act upon such other matters that may  properly come before the
               meeting or any adjournment or postponement of the meeting.

         The foregoing  items of business are more fully  described in the proxy
statement  accompanying this notice. Only stockholders of record at the close of
business  on March 16,  1999 will be  entitled  to notice of and to vote at this
meeting and any adjournment or postponement thereof.

                                        By Order of the Board of Directors

                                        JOHN H. NEWMAN
                                        Secretary

Mountain View, California
March 31, 1999

ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.  WHETHER
OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE,  DATE, SIGN AND RETURN
THE   ENCLOSED   PROXY  AS   PROMPTLY  AS  POSSIBLE  IN  ORDER  TO  ENSURE  YOUR
REPRESENTATION  AT THE MEETING.  A RETURN ENVELOPE (WHICH IS POSTAGE PRE-PAID IF
MAILED IN THE UNITED  STATES) IS  ENCLOSED  FOR THAT  PURPOSE.  EVEN IF YOU HAVE
GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE
NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER
NOMINEE  AND YOU WISH TO VOTE AT THE  MEETING,  YOU MUST  OBTAIN FROM THE RECORD
HOLDER A PROXY ISSUED IN YOUR NAME.


<PAGE>





                                   Scios Inc.
                              2450 Bayshore Parkway
                         Mountain View, California 94043
                                   ----------

                                 Proxy Statement
                         Annual Meeting of Stockholders
                                  May 11, 1999


General

         The enclosed  proxy is solicited on behalf of the Board of Directors of
Scios Inc., a Delaware  corporation  (the "Company" or "Scios"),  for use at its
Annual Meeting of Stockholders to be held at the Company's  principal  executive
offices, 2450 Bayshore Parkway, Mountain View, California 94043, at 8:30 a.m. on
Tuesday,  May 11, 1999, and at any  adjournment or postponement of that meeting,
for the  purposes  set forth  herein  and in the  accompanying  Notice of Annual
Meeting.  The approximate mailing date for this Proxy Statement and the enclosed
proxy is March 31, 1999.

         The Board of  Directors  has fixed the close of  business  on March 16,
1999 as the record date for the  determination of stockholders  entitled to vote
at the Annual  Meeting.  At that time,  there were  37,770,114  shares of Common
Stock issued and outstanding (net of Treasury Shares).

Voting

         Each share of Common Stock issued and outstanding on the record date is
entitled to one vote. The proxy holders will vote all proxies in accordance with
the  instructions  contained  in the proxy and, if no choice is  specified,  the
proxy  holders  will vote in favor of the  proposals to elect  directors  and to
ratify the  selection  of  auditors.  An automated  system  administered  by the
Company's transfer agent tabulates the votes. The presence at the Annual Meeting
in person or by proxy of a majority of the shares  outstanding  as of the record
date will  constitute a quorum.  Abstentions  and broker  non-votes  are counted
towards a quorum. Each matter is tabulated  separately.  Abstentions are counted
in tabulations of the votes cast on proposals presented to stockholders and have
the effect of negative votes,  whereas broker  non-votes are not counted for any
purpose in determining whether a proposal has been approved.

Revocability of Proxies

         Any person giving a proxy in the form accompanying this Proxy Statement
has the power to revoke it at any time before its exercise. It may be revoked by
filing  with  the  Secretary  of the  Company  an  instrument of  revocation  or
a  duly  executed  proxy  bearing  a  later date.  It  also  may  be  revoked by
attending  the meeting  and voting in person. Attendance at the meeting will not
itself revoke a proxy.

Solicitation

         The  Company  will  bear  the  entire  cost of  preparing,  assembling,
printing  and  mailing  this Proxy  Statement,  the  accompanying  proxy and any
additional  material  which may be  furnished  to  stockholders  by the Company.
Copies of  solicitation  material  will be  furnished  without  charge to banks,
brokerage  houses,  fiduciaries  and custodians  holding in their name shares of
Common Stock  beneficially owned by others to forward to such beneficial owners.
The  solicitation  of proxies  will be made by the use of the mails and  through
direct  communication  with certain  stockholders  or their  representatives  by
officers, directors and employees of the Company, who will receive no additional
compensation  therefor.  In  addition,  the  Company  may  determine  to  engage
Corporate  Investor  Communications,  Inc. or another proxy solicitor to solicit
proxies  and, if it does so, the  Company  will pay the  standard  fee for these
services, which is estimated to be approximately $3,000.
<PAGE>

                                   PROPOSAL 1
                              ELECTION OF DIRECTORS

         A Board of eight (8) Directors  will be elected at the Annual  Meeting.
The term of office of each person  elected as a Director will continue until the
next Annual  Meeting or until a successor  has been  elected.  Unless  otherwise
instructed,  the proxy  holders  will vote the proxies  received by them for the
eight nominees of the Board of Directors named below,  all of whom are presently
Directors of the Company.  The candidates  receiving a plurality of the votes of
the shares present in person or represented by proxy at the meeting and entitled
to vote will be elected.  Each person nominated for election has agreed to serve
if elected,  and  management  has no reason to believe  that any nominee will be
unable to serve.  If any  nominee for any reason is unable or declines to serve,
the proxies will be voted for any substitute  nominee who shall be designated by
the present Board of Directors to fill the vacancy.  Stockholders  who desire to
nominate  persons for election to the Board must comply with the advance  notice
procedures specified in the Company's Bylaws.

         The  following  is  information   regarding  the  nominees,   including
information furnished by them as to their principal occupation for the preceding
five-year period, certain directorships and their ages as of March 16, 1999.
<TABLE>
<CAPTION>

                                                        Director
         Name                                Age        Since
         ----                                ---        --------
         <S>                                 <C>        <C>

         Samuel H. Armacost                  59         1995
         Richard B. Brewer                   47         1998
         Myron Du Bain                       75         1989
         Donald B. Rice, Ph.D.               59         1997
         Charles A. Sanders, M.D.            67         1997
         Solomon H. Snyder, M.D.             60         1992
         Burton E. Sobel, M.D.               61         1996
         Eugene L. Step                      70         1993
</TABLE>

         Mr.  Armacost was elected to the Company's Board of Directors in August
1995. In July 1998, Mr.  Armacost  became  Chairman of the Board of Directors of
SRI International.  From 1990 to 1998, he was a Managing Director of Weiss, Peck
& Greer, L.L.C., an investment firm. He was a Managing Director of Merrill Lynch
Capital Markets from 1987 to August 1990, and was President,  Director and Chief
Executive Officer of BankAmerica  Corporation from 1981 to 1986. Mr. Armacost is
a member of the Board of Directors of Chevron Corporation and Exponent,  Inc. In
addition,  Mr.  Armacost  is on the  Board  of  Directors  of the  James  Irvine
Foundation and the Advisory Board of the California Academy of Sciences,  and he
is a member of The Business Council.

         Mr. Brewer is President  and Chief  Executive  Officer of Scios Inc. He
joined  Scios in  September  1998 and has served as a Director  since that time.
From early  1996 to 1998, he was with  Heartport  Inc.  first as Executive  Vice
President of Operations and then,  Chief Operating  Officer.  Prior to that, Mr.
Brewer served in various capacities with Genentech, Inc. from 1984 to 1995, most
recently as Senior Vice President,  U.S. Sales and Marketing,  Genentech  Europe
Ltd.,  and  Genentech  Canada,  Inc.  Mr.  Brewer  earned  a B.S.  from Virginia
Polytechnic Institute and a M.B.A. from Northwestern University.

         Mr.  Du Bain was  elected  a  Director  of Scios in June  1989.  He was
Chairman of the Board of Directors of SRI International from December 1985 until
he retired in  December  1989.  From 1983 to 1985,  he was  President  and Chief
Executive  Officer  of  Amfac,   Inc.,  a  diversified   distribution   company.
Previously,  Mr. Du Bain was Chairman,  President and Chief Executive Officer of
Fireman's Fund  Corporation  and Vice Chairman of the Board of American  Express
Company.  He was  formerly a member of the Board of  Directors  of Wells Fargo &
Company,  Pacific Gas and Electric Co., Pacific Telesis Group,  First Interstate

<PAGE>

Bancorp,  Potlatch  Corporation,  Carter Hawley Hale Stores Inc.,  The Chronicle
Publishing Co., Transamerica Corporation and several other corporations.  He was
also  Chairman of the Board of  Directors  of the James  Irvine  Foundation  and
served on numerous boards of non-profit organizations.

         Dr. Rice was  elected  Chairman of the Board in  November  1998 and has
served  as a  Director of Scios since  August  1997.  Dr. Rice is the President,
Chief Executive Officer and Director of UroGenesys,  Inc.  Previously, he served
Teledyne,  Inc. as President, Chief  Operating  Officer and  Director  from 1993
to 1996, the U.S.  Department of Defense as Secretary of the Air Force from 1989
to 1993, and The RAND Corporation as President and Chief Executive  Officer from
1972 to 1989. He was also  Assistant  Director of the Office of  Management  and
Budget,  The White House.   Dr. Rice  is  a member of the Board of  Directors of
Wells Fargo & Company,  Vulcan Materials Company and Unocal Corporation.

         Dr.  Sanders  was  elected  a Director of Scios in September  1997.  He
served  as  Chief  Executive  Officer of  Glaxo Inc. from 1989 to 1994,  and was
Chairman  of  the  Board  from  1992  to 1995.  He  also  served on the Board of
Directors  of Glaxo plc.  Previously,  he held a number of  positions  at Squibb
Corporation,  a  multinational   pharmaceutical   corporation,   including  Vice
Chairman,  Chief  Executive  Officer  of  the  Science and Technology  Group and
Chairman of the Science and Technology  Committee of the Board. Dr. Sanders is a
member   of  the   Board   of  Directors  of  Magainin  Pharmaceuticals,  Vertex
Pharmaceuticals,  Staff  Mark, Inc.,   Kendle  International, Trimeris, and
Pharmacopeia.

         Dr.  Snyder was  elected a Director  in  September  1992.  Dr.  Snyder
is  Director  of the  Department  of  Neuroscience  and Distinguished   Service
Professor of Neuroscience,  Pharmacology and  Molecular Sciences and Psychiatry
at  The  Johns Hopkins  University,  and has been a member of the faculty there
since 1966. Dr. Snyder  received  the  Albert Lasker Award for Basic  Biomedical
Research  and  Honorary  Doctor of Science degrees from Northwestern University,
Georgetown  University and Ben Gurion University.  Dr. Snyder received the Wolfe
Award  in  Medicine  from  the  government  of  Israel for research  relating to
receptors.   Dr. Snyder  is  a member  of the National Academy of Sciences and a
Fellow  of  the  American Academy of Arts and Sciences.   Dr. Snyder is also the
author of numerous  articles  and  several books.  Dr. Snyder is a founder and a
director of Guilford Pharmaceuticals Inc.

         Dr.  Sobel  was  elected  a  Director  in  February 1996.  Dr. Sobel is
Physician-in-Chief,  E.L.  Amidon  Professor  and  Chair  of  the  Department of
Medicine  at The  University  of Vermont  College of Medicine.  Previously,  Dr.
Sobel was Professor of Medicine at Barnes Hospital,  Washington  University  and
Director of its  Cardiovascular  Division.  Dr.  Sobel has been a  consultant to
and   served  on   scientific  advisory  boards of several  pharmaceutical  and
biotechnology   companies.   Dr.  Sobel  has  been   the  recipient of  numerous
awards,  including the American Heart  Association's James B.  Herrick Award and
its  Scientific   Council's  Distinguished  Achievement  Award, as  well  as the
American  College  of  Cardiology's  Distinguished  Scientist  Award.  Dr. Sobel
has  been  the  editor of  Circulation  and, since 1989, has served as editor of
Coronary Artery Disease.  His  memberships and  fellowships include the American
College of Physicians, Royal  Society of Medicine, American  Heart  Association,
American  College of  Cardiology  and  Fellowship  and Council membership in the
American Association for the Advancement of Science.

         Mr. Step was elected a Director in February 1993.  From May 1956  until
he  retired in  December 1992,   Mr. Step was employed by Eli Lilly and Company,
most  recently  as  Executive  Vice President,  President  of the Pharmaceutical
Division,  where he was responsible for U.S.  pharmaceutical  operations and for
the operations of Eli Lilly  International. In addition,  Mr. Step served on Eli
Lilly's Board of Directors  and  executive  committee.  Mr. Step was Chairman of
the  Board of  Directors  of  the  Pharmaceutical  Manufacturers Association and
President  of  the  International  Federation  of  Pharmaceutical  Manufacturers
Associations.  He  is a  member  of the Board of Directors of Cell Genesys Inc.,
Guidant  Corporation,  Medco Research  Inc., Pathogenesis  Corporation  and  DBT
Online Inc.
<PAGE>

                  INFORMATION ABOUT THE BOARD OF DIRECTORS AND
                             COMMITTEES OF THE BOARD

         Compensation of Directors

         General.  During 1998,  the Company  reduced the cash  compensation  to
non-employee  Directors in the form of retainer and meeting fees and,  following
stockholder  approval,  instituted an annual stock option grant to  non-employee
Directors.  It is the Company's  belief that these changes are  constructive  in
building  director equity interests in the Company and more closely aligning the
interests  of the Board,  management  and  stockholders  in  building  long-term
stockholder value.

         Fees.  Directors who are not otherwise  employed by the Company receive
an annual  retainer  of $8,000  and a fee of $1,000  per day for  attendance  at
regular meetings of the Board of Directors or committee  meetings,  and $500 for
attendance   at  a  telephonic   meeting.   Directors   are  also  eligible  for
reimbursement  of  expenses  incurred in  connection  with  attendance  at Board
meetings in accordance with Company policy.

         Stock Options.  In May 1998, the  stockholders of the Company  approved
an amendment of the Company's 1992 Equity  Incentive Plan (the "Equity Plan") to
provide that each non-employee  Director shall automatically be granted, at each
annual  meeting  where  the  Director  is  elected  to  the  Company's  Board, a
supplemental  stock  option  to  purchase  10,000 shares of the Company's Common
Stock.  Such options are granted with exercise prices equal to the current  full
market price. Only non-employee Directors of the Company are eligible to receive
options  under  the applicable  provisions of the Equity Plan, and Mr. Armacost,
Mr. Du Bain,  Dr. Rice,  Dr. Sanders,  Dr. Snyder,  Dr. Sobel and  Mr. Step each
received  an  automatic  option grant at the time of re-election to the Board in
May, 1998.

         Board of Directors.  During 1998, there were 9 meetings of the Board of
Directors.

         Chairman of the Board.  In connection with the employment of Richard B.
Brewer  as the  Company's  President  and  Chief  Executive  Officer  and at Mr.
Brewer's request,  the Board determined that separating the roles of Chairman of
the Board and Chief Executive Officer was a constructive step for the Company at
the present time.  Accordingly,  on November 3, 1998, Donald B. Rice was elected
Chairman of the Board, a nonexecutive position, and for serving in this role the
Board awarded Dr. Rice additional cash  compensation of $7,500 per quarter and a
supplemental  stock option to purchase  15,000  shares of the  Company's  Common
Stock at the then current market price.

         Audit Committee.  The  Audi  Committee  consists  of  four non-employee
Directors:  Mr. Step (Chairman),  Mr. Armacost, Dr. Sanders and Dr.  Sobel.  The
Audit  Committee  met four times in 1998.  Among the  committee's  functions are
recommending   engagement  of  the  Company's  independent  auditors,  approving
services performed by such auditors,  and reviewing and evaluating the Company's
accounting systems and its system of internal accounting controls.

         Management   Development and Compensation  Committee.    The Management
Development and Compensation Committee consists of five non-employee  Directors:
Mr.  Armacost  (Chairman),  Mr. Du Bain,  Dr. Rice,  Dr.  Sanders and  Mr. Step.
The committee met four times during 1998.  Among the  committee's  functions are
establishing  the Company's  compensation  programs  for  all employees,  fixing
the compensation levels of executive  officers of the Company, and administering
and making awards under the Company's incentive programs.

         Nominating  Committee.   The  Nominating  Committee  consists  of  four
non-employee  Directors:   Mr. Du Bain  (Chairman),  Dr. Rice,  Dr. Schrier  and
Dr.  Snyder.   The  committee  met  three  times  in  fiscal  1998.   Among  the
committee's   functions  are  recommending   nominees  to  serve  on  the  Board
of Directors,  recommending  the  size  and  composition  of  the  Board, making
recommendations  concerning   membership   of  Board  committees  and   Director
compensation,  and  consulting  with  the  Board  of  Directors  and  management

<PAGE>

to  determine  criteria for nominations.  The  Nominating  Committee
will  consider nominees recommended by stockholders.

         Management Succession Committee.  During  1998,  the Board  established
a  Management  Succession  Committee to oversee the recruiting  of  a  new Chief
Executive  Officer  for  the Company.  The Committee  consisted of Mr. Armacost,
Mr. Du Bain, Dr. Rice and Mr. Step. It met formally as a  committee  four  times
and  informally  on  numerous  occasions  as  part  of  the  search  process and
recruiting  Mr. Brewer  to the Company.  The Committee was disbanded in November
1998.

         In 1998,  all  Directors  attended at least 75% of the  meetings of the
Board and committees of the Board of which they were members, except Dr. Schrier
who attended 58% of meetings.


<PAGE>



           SECURITY OWNERSHIP OF MANAGEMENT AND PRINCIPAL STOCKHOLDERS

                              Beneficial Ownership

         The  following  table  sets forth  certain  information  regarding  the
beneficial  ownership of the Company's Common Stock at March 16, 1999 by (i) all
persons  known by the  Company  to be  beneficial  owners of more than 5% of its
Common Stock, (ii) each Director,  (iii) each of the executive officers named in
the  Summary  Compensation  Table  included  herein and (iv) all  Directors  and
executive officers of the Company as a group.

<TABLE>
<CAPTION>
                                              Beneficial Ownership(1)
                                      Beneficially               Approximate
Officers, Directors &                 Owned                      Percent
5% Stockholders                       Shares(2)                  of Class
<S>                                   <C>                        <C>

Samuel H. Armacost                     50,000                        *
Richard B. Brewer                     165,000                        *
Richard L. Casey                      494,192(3)                     1%
Myron Du Bain                          64,500(3)                     *
Donald B. Rice, Ph.D.                  44,166                        *
Charles A. Sanders, M.D.               16,333                        *
Solomon H. Snyder, M.D.                33,333                        *
Burton E. Sobel, M.D.                  23,000                        *
Eugene L. Step                         33,500                        *
Elliott B. Grossbard, M.D.            245,949                        *
John H. Newman                        238,382(3)                     *
John A. Lewicki, Ph.D.                189,233                        *
Thomas L. Feldman                      80,864                        *
All officers and directors as a
  group (14 persons)                1,708,252(3)                     4%
- ----------
<FN>
* less than 1%
(1)      Unless  otherwise  indicated  below and subject to  community  property
         laws,  each  stockholder  has sole  voting  and  investment  power with
         respect to the shares beneficially owned.

(2)      For Mr. Armacost,  Mr. Brewer, Mr. Casey,  Mr. Du Bain,  Dr. Rice,  Dr.
         Sanders,  Dr. Snyder,  Dr. Sobel, Mr. Step, Dr. Grossbard,  Mr. Newman,
         Dr. Lewicki and Mr. Feldman, and all officers and directors as a group,
         includes  25,000;  65,000; 453,332;  34,500;  24,166;  16,333;  13,333;
         23,000;  32,500;  239,665;  144,332;  173,332;  78,164;  and  1,322,657
         shares,  respectively, issuable  upon  exercise  of outstanding options
         exercisable within sixty days of March 16, 1999.

(3)      With respect to Mr.  Casey,  includes  6,837 shares held in a trust for
         the benefit of Mr.  Casey's  children,  of which Mr. Casey and his wife
         are trustees.  With respect to Mr. Du Bain, includes 25,000 shares held
         in a  revocable  living  trust for the  benefit  of Mr. Du Bain and his
         wife;  Mr. Du Bain is a trustee  of such  trust.  With  respect  to Mr.
         Newman,  includes  7,000  shares held in his  spouse's  IRA account and
         2,000 shares held for the benefit of Mr. Newman's children.
</FN>
</TABLE>

         The  Company  is not  aware of any  material  proceeding  to which  any
Director  or  executive  officer  of the  Company or any  associate  of any such
Director or  executive  officer is a party  adverse to the Company or any of its
subsidiaries  or has a material  interest  adverse to the  Company or any of its
subsidiaries.

Compliance with Section 16(a) of the Exchange Act

         Section 16(a) of the  Securities  Exchange Act of 1934, as amended (the
"Exchange  Act"),  requires  the  Company's  Directors,  executive  officers and
holders of more than ten  percent  (10%) of the  Company's  Common  Stock  ("10%
Holders")  to file with the  Securities  and  Exchange  Commission  (the  "SEC")

<PAGE>

initial reports of ownership and reports of changes in ownership of Common Stock
and other equity securities of the Company.  Directors,  executive  officers and
10% Holders are required by SEC regulation to furnish the Company with copies of
all Section 16(a) forms they file.

         The Company  believes  that during the fiscal year ended  December  31,
1998,  its  Directors,  executive  officers  and 10% Holders  complied  with all
Section 16(a) filing  requirements.  In making this  statement,  the Company has
relied upon the written representations of its Directors, executive officers and
certain other reporting persons.



<PAGE>



                             EXECUTIVE COMPENSATION

         The following  table discloses  compensation  received by the Company's
Chief  Executive  Officers  and each of its four other most  highly  compensated
executive  officers at December 31, 1998 for the fiscal years ended December 31,
1998, 1997 and 1996.

<TABLE>
<CAPTION>
                           SUMMARY COMPENSATION TABLE

                                                                           Long-Term
                                                                           Compensation
                                      Annual Compensation                  Awards
                                      -------------------                  ------------
Name                                                                                      Securities
and                                                                        Restricted     Underlying     All Other
Principal                                                                  Stock          Stock          Compen-
Position                      Year        Salary ($)     Bonus (1)($)      Award (2)($)   Options(#)     sation (3)($)
- --------                      ----        ----------     ------------      ------------   ----------     -------------
<S>                           <C>         <C>            <C>               <C>            <C>            <C>

Richard B. Brewer             1998        $103,000(4)    $  50,000         $596,875       275,000        $  3,000
  President and Chief         1997          N/A
  Executive Officer           1996          N/A

Richard L. Casey              1998        $302,852(5)    $  86,400               --       100,000        $ 53,000(6)
  Former Chairman of          1997        $400,000              --               --            --        $  3,000
  the Board  and Chief        1996        $400,000       $ 120,000               --       100,000        $  3,000
  Executive Officer

Elliott B. Grossbard, M.D.    1998        $260,000       $ 100,000               --        68,500        $  3,000
  Senior Vice President       1997        $246,064              --               --        19,000        $  3,000
  of Development              1996        $218,500       $ 105,000(7)            --         9,375        $  3,000

John H. Newman                1998        $220,000       $  50,000               --        53,500        $  3,000
  Senior Vice President,      1997        $212,500              --               --        19,000        $  3,000
  General Counsel &           1996        $185,500       $  65,000               --         9,375        $  3,000
  Secretary

John A. Lewicki, Ph.D.        1998        $222,000       $  50,000               --        50,000        $  3,000
  Vice President              1997        $222,000              --               --        12,000        $  3,000
  of Research                 1996        $215,500       $  40,000               --         6,250        $  3,000

Thomas L. Feldman             1998        $185,000       $  95,000(8)            --        38,500        $  3,000
  Vice President of           1997        $185,000       $  55,000(8)            --        16,000        $  3,000
  Commercial Development      1996        $175,300       $  70,000               --         6,250        $  3,000
- ---------------
<FN>
(1)   Except  as is  further  described  in  footnote  7  below,  bonus  amounts
      represent the value of awards under the Company's Employee Incentive Plan.
      Awards to executive  officers under this plan are  determined  annually by
      the Compensation Committee.

(2)   Mr.  Brewer  received  100,000  shares of Common Stock valued on the grant
      date at $5.96875 per share upon  becoming  President  and Chief  Executive
      Officer  (See  Note 4).  50% of the  shares  vest on each of the first and
      second anniversary of his employment.
      The aggregate value of such shares on December 31, 1998 was $1,037,500.

(3)   Consists of Company matching contributions under the 401(k) Profit Sharing
      Plan and Trust,  which was  established  in 1986. As of December 31, 1998,
      the  Company  made   matching   contributions   of  100%  of   participant
      contributions,  up to a maximum of $3,000 per  participant  per plan year.
      Employee  contributions  are at  all  times  100%  vested.  The  Company's
      contributions  vest based on years of service:  0% for less than one year;
      25% for one but less  than two  years;  50% for two but  less  than  three

<PAGE>

      years;  and 100% for  three or more  years.  Federal  tax laws  impose  an
      overall limit on the amount that may be contributed by  participants  each
      year under 401(k) plans.

(4)   Mr. Brewer  became  President and  Chief  Executive Officer of the Company
      at  an  annual  salary  of  $400,000  in  September  1998 upon Mr. Casey's
      retirement.

(5)   Mr. Casey retired as  an officer  and director of the Company in September
      1998 and is now a consultant to the Company.

(6)   Includes  $50,000  in  consulting  fees  paid  to  Mr. Casey  in 1998 (See
      Note 5).

(7)   Includes  forgiveness  of  $30,000  under  a  relocation  loan made to Dr.
      Grossbard at the time he joined the Company.

(8)   Mr. Feldman's bonus for 1997 and 1998 includes  forgiveness of $55,000 per
      year under a relocation loan made to him in 1996 as part of the relocation
      of  the  Commercial  Operations  Division  to  California.   See  "Certain
      Relationships and Transactions."
</FN>
</TABLE>


                        STOCK OPTION GRANTS AND EXERCISES

      In the  Company's  efforts  to  recruit  the best  available  talent  in a
competitive  labor market,  the Company  grants stock options to provide  equity
incentives. The Company has granted stock options under the 1983 Incentive Stock
Option Plan (expired by its terms on March 5, 1993), the 1986 Supplemental Stock
Option Plan  (expired by its terms on January 16, 1996),  the 1989  Non-Employee
Director  Stock Option Plan  (expired by its terms on June 30,  1994),  the 1992
Equity and Incentive Plan and the 1996 Non-Officer Stock Option Plan.

      The  following  table  provides  information  on stock options held by the
executive  officers  named  in  the  Summary   Compensation   Table,   including
information  as to grants and exercises  for the fiscal year ended  December 31,
1998.

<TABLE>
<CAPTION>
                                          Option Grants in Last Fiscal Year

                                                                                 Potential Realizable Value at
                                                                                 Assumed Annual Rates of Stock
Individual Grants                                                                Price Appreciation for Option Term
- --------------------------------------------------------------------------       ---------------------------------- 

                No. of           % of Total
                Securities       Options          Exercise
                Underlying       Granted to       or Base
                Options          Employees in     Price          Expiration
Name            Granted(1)(#)    Fiscal Year      ($/Sh)         Date            0%($)        5%($)           10%($)
- ----            -------------    ------------     --------       ----------      -----        -----           ------
<S>             <C>              <C>              <C>            <C>             <C>          <C>             <C>

R. Brewer       275,000          22.17%           $5.97          09/09/08        0            $1,032,272      $2,615,979
R. Casey        100,000           8.06%           $9.63          12/31/00(2)     0            $  145,921      $  305,607
E. Grossbard     68,500           5.52%           $9.63          02/09/08        0            $  414,638      $1,050,774
J. Newman        53,500           4.31%           $9.63          02/09/08        0            $  323,841      $  820,678
J. Lewicki       50,000           4.03%           $9.63          02/09/08        0            $  302,656      $  766,989
T. Feldman       38,500           3.10%           $9.63          02/09/08        0            $  233,045      $  590,581
- ---------
<FN>
(1)  These  options vest in monthly  installments  commencing on January 1, 1998
     and ending on December 31, 2002. See  "Compensation  Committee  Report" for
     additional  information  on these stock  options.  All grants in this table
     were made pursuant to the 1992 Equity Incentive Plan.

(2)  Pursuant  to  Mr.  Casey's   retirement,   his  options  vest  through  the
     termination of his consulting  agreement at which time he will have 90 days
     to exercise the vested options.
</FN>
</TABLE>
<PAGE>

<TABLE>
<CAPTION>

                 Aggregated Option Exercises in Last Fiscal Year
                            and FY-End Option Values

                                                                                               Value of Unexercised,
                       Shares                      Number of Securities Underlying              In-the-Money Options
                    Acquired on        Value        Unexercised Options at FY-End                    at FY-End
Name                Exercise(#)     Realized($)    Exercisable(#)  Unexercisable(#)      Exercisable(1)($)   Unexercisable(1)($)
- ----                -----------     -----------    --------------  ---------------       -----------------   -------------------
<S>                 <C>             <C>            <C>             <C>                   <C>                 <C>
R. Brewer                 0                0         65,000         210,000                $286,406          $925,312

R. Casey            200,000         $630,563        425,000         235,000              $1,166,250          $754,000
                   

E. Grossbard              0                0        227,125          88,750                $439,219          $176,320
                                        

J. Newman            40,000         $133,125        132,375          75,000                $324,219          $157,258


J. Lewicki           40,000         $131,937        162,500          74,750                $393,250          $163,234

T. Feldman                0                0         69,208          61,542                $187,494          $145,866
- ------------------ 
<FN>

(1) Based on the fair market value of the Company's Common Stock at December 31,
    1998 ($10.375) minus the exercise price of the options.
</FN>
</TABLE>

<PAGE>



                       EMPLOYMENT AND SEVERANCE AGREEMENTS

         Richard B. Brewer  became the Company's  President and Chief  Executive
Officer in September 1998.  Pursuant to the employment  offer between Mr. Brewer
and the Company,  Mr.  Brewer is to be  compensated  at the rate of $400,000 per
annum and he received  options to purchase 275,000 shares of Common Stock of the
Company at an exercise  price of $5.97 per share,  vesting in annual  increments
over 4 years, and a restricted stock grant for 100,000 shares ($596,875 value at
grant),  vesting in equal amounts on the first two  anniversaries  of Mr. Brewer
joining  the  Company.  Both  grants  were at the  current  market  price of the
Company's Common Stock at the time of grant.

         Richard L. Casey  retired as the  Company's  Chairman  of the Board and
Chief Executive Officer in September 1998.  Pursuant to an agreement between Mr.
Casey and the  Company,  Mr.  Casey will serve as a  consultant  to the  Company
through September 2000, with compensation of $16,667 per month.

                        COMPENSATION COMMITTEE REPORT(1)

         The Compensation Committee of the Board of Directors (the  "Committee")
is  responsible for  establishing  the  Company's compensation  programs for all
employees,  including   executives.   For  executive   officers,  the  Committee
evaluates performance and determines specific compensation  policies and levels.
In 1998, the Committee was composed of Mr. Armacost, Mr. Du Bain,  Dr. Rice, Dr.
Sanders and Mr. Step.  None of these directors were officers or employees of the
Company.

Compensation Philosophy

         The goals of the  compensation  program are to link  compensation  with
business  objectives  and  performance,  and to enable the  Company to  attract,
retain and reward  executive  officers and other key employees who contribute to
the long-term success of the Company and to build long-term  stockholder  value.
Key elements of this philosophy are:

     o   The Company pays  competitively  with leading  biotechnology  and other
         companies  with which the Company  competes for  management or employee
         talent.  To  ensure  that pay is  competitive,  the  Company  regularly
         compares  its  pay  practices   with  these   companies  and  sets  its
         compensation parameters based on this review.

     o   The Company  maintains  annual  incentive  opportunities  sufficient to
         provide  motivation to achieve specific  business goals and to generate
         rewards that bring total compensation to competitive levels.

     o   The Company provides significant equity-based incentives for executives
         and other key employees to ensure that they are motivated over the long
         -term to  respond  to  the  Company's business challenges and strategic
         opportunities as owners as well as employees.
- ---------
(1)  The  material  in this  report and the chart on  page 15 is not "Soliciting
     Material",  is not deemed  "filed"  under the  Securities  Act of 1933,  as
     amended,  or the  Exchange Act and is not to be  incorporated  by reference
     into any  filing  of the  Company  whether  made  before  or after the date
     hereof, regardless of any general incorporation language in such filing.

         The primary  components  of  executive  compensation  are base  salary,
annual incentives and long-term equity incentives. Over the last five years, the
Committee  has not  granted a salary  increase  to the CEO and has only  granted
modest or no salary  increases  over the last three  years to other  executives.
These actions reflect the Committee's intent to lower the relative percentage of
fixed compensation and increase the relative  percentage of pay at risk based on
performance.

         The  Committee's  objective  in  general  is to set each  component  of
executive  compensation  at the market  average  when  compared to a  nationwide
survey of the  biotechnology  industry (the  "comparator  group").  In 1998, the

<PAGE>

comparator group contained approximately 300 companies. Many of the companies in
the  comparator  group are included in the  Performance  Graph  included in this
Proxy Statement.

         Base Salary.  The Committee  annually reviews each executive  officer's
base salary  against the base salaries  paid for similar  positions by companies
within the  comparator  group.  A range of salary levels is  established by this
comparison  targeted at the 50th  percentile  salary for  comparable  positions.
Within this range,  the Committee  subjectively  considers  individual  factors,
including individual performance, level of responsibility,  prior experience and
breadth of  knowledge,  as well as  competitive  pay practices and the extent to
which the Company  achieved its  corporate  objectives  described in the section
below entitled Annual  Incentive.  From year to year, the relative  weighting of
the  individual  components and the corporate  performance  component may differ
from officer to officer,  and can be expected to change over time in response to
the Company's evolution.

         Annual  Incentive.  The Employee  Incentive Plan, an annual award plan,
offers variable pay for officers and other employees of the Company based on the
extent to which Company and individual  performance  objectives are achieved. At
the start of each year, the Committee and the full Board of Directors review and
approve  the  annual  performance  objectives  for the  Company  and  individual
officers.  The Company objectives consist of operating,  strategic and financial
goals that are  considered  to be critical to the  Company's  long-term  goal of
building stockholder value. For 1998, these objectives included:

     o    completing  the  key  development  benchmarks for  the  Company's lead
          products - NATRECOR(R) hBNP and  FIBLAST(R) trafermin -  that had been
          identified for accomplishment in 1998

     o    securing commercial partners for certain of the Company's technologies
          and commercial operations

     o    financial performance related to the Company's cash utilization

     o    identifying  and  developing  additional  products  from the Company's
          research  pipeline  as candidates for clinical testing and  developing
          lead compounds for future research and development

         After the end of the year, the Committee  evaluates the degree to which
the Company has met its  objectives  and, at the  discretion  of the  Committee,
establishes  a total  incentive  award pool under the Employee  Incentive  Plan.
Individual awards are determined by evaluating the Company's overall performance
and by evaluating  each  participant's  performance  against  objectives for the
year.  The  incentive  award pool is then  allocated  based on that  assessment.
Awards are paid in cash and  distributions  are made in February  following  the
performance  year.  In lieu  of  making  cash  awards  to  executives  for  1997
performance,  the Committee  elected to distribute  annual  incentive  awards to
executives  in the form of  additional  stock  option  grants  vesting over four
years.

         In February  1999,  the  Committee  determined  that the  Company  made
significant progress in 1998, and that most of its key corporate objectives were
met. Specifically,  the Company: filed an NDA in the United States for NATRECOR;
completed development of the manufacturing  processes for NATRECOR and validated
those processes;  secured a worldwide  commercial partner for NATRECOR which was
accomplished  through the  agreement  with Bayer AG;  prepared for the launch of
NATRECOR;  extended its agreement with a third party  manufacturer  of NATRECOR;
advanced another product into development;  identified lead targets in discovery
research,  and met  certain  financial  objectives.  The  Company  was not fully
successful  in  advancing  the  clinical  development  of FIBLAST.  Based on the
Company's  performance,  the Committee  determined  the incentive pool available
under the Employee  Incentive  Plan.  The  Committee  then  determined  the cash
incentive award for each of the executives on the Company's corporate management
committee  reflecting  their  individual and collective  1998  performance.  The
Committee  exercised  its  discretion  and  approved  bonuses for members of the
corporate  management  committee that totaled less than the pool available.  The
former CEO, Mr. Casey, received a prorated award for the nine months during 1998
that he was CEO.


<PAGE>

         Long-Term  Incentives.  The Company's  long-term  incentive program for
officers  consists of the 1983  Incentive  Stock Option Plan,  (expired March 5,
1993),  the 1986  Supplemental  Stock Option Plan (expired January 16, 1996) and
the 1992 Equity  Incentive  Plan. The option program  utilizes  vesting  periods
(generally  four years) to encourage  key employees to continue in the employ of
the Company  and to look to achieve the  Company's  long-term  strategic  goals.
Through option grants, executives receive significant equity incentives to build
long-term  stockholder value. All grants have been made at or above 100% of fair
market value on the date of grant.  Executives  receive  value from these grants
only if the Company's Common Stock  appreciates over the long-term.  The size of
option  grants  generally  is  determined  based  on  competitive  practices  at
companies in the comparator group and the Company's  philosophy of significantly
linking executive  compensation  with stockholder  interests.  In addition,  the
Committee  considers  the terms and  number of  options  previously  awarded  in
determining the size of option grants.

         In 1996, 1997 and 1998, the Committee reviewed the equity incentives of
executive officers and made additional grants in each year to remain competitive
with the comparator group and maintain appropriate  long-term incentives for key
individuals.  These grants will vest during 1998  through  2002.  The  Committee
believes  the approach of making  grants that vest over an extended  time period
creates an appropriate  focus on longer term  objectives and promotes  executive
retention.

         Section  162(m) of the Internal  Revenue Code limits the federal income
tax  deductibility of compensation  paid to the Company's CEO and to each of the
other four most highly compensated executive officers.  The Company intends that
the long-term incentive compensation paid to these executives will be deductible
by the  Company  under  Section  162(m).  In 1998,  the Board  and  stockholders
approved  amendments  to the 1992  Equity  Incentive  Plan  intended to meet the
requirements of Section 162(m).

Chief Executive Officer Compensation

         In the fall of 1992,  the  Committee  retained  Hewitt  Associates  (an
international  employee  compensation and benefits consulting firm) to conduct a
comprehensive  review  of  the  base  salaries  and  incentive  compensation  of
executive  officers in an  appropriate  comparator  group.  Following the Hewitt
Associates  review,  the  Committee  set Mr.  Casey's 1993 base annual salary at
$400,000.  This  amount,  in  addition to the annual  incentive  provided by the
Employee  Incentive  Plan, was estimated to provide an annual cash  compensation
level at the  average  of the  comparator  group.  For 1994  through  1998,  the
Committee  elected to maintain the CEO's base salary at  $400,000.  In doing so,
the  Committee  intended to  increase  the  relative  portion of the CEO's total
compensation  that is variable pay based on achievement of the annual  corporate
objectives  and on  increases  in the  Company's  stock  price.  Mr.  Casey  was
compensated in accordance  with the foregoing  until his retirement in September
1998. In connection with his retirement,  Mr. Casey was awarded a prorated bonus
equal to his base salary multiplied by 75% of the bonus pool percentage.  At the
time of his  retirement,  the Company  retained Mr. Casey as a consultant  for a
period of two years. See "Employment and Severance Agreements" above.

         When Mr.  Brewer  was  hired as  President  and CEO of the  Company  in
September,  1998,  the  Committee  established  his base salary at $400,000  per
annum, the same annual salary as Mr. Casey had received.  In connection with Mr.
Brewer's joining the Company,  the Committee agreed to certain other elements of
compensation,  including the stock options,  restricted stock and bonus for 1998
appearing in the Summary  Compensation Table and other future benefits described
under the caption "Employment and Severance  Agreements." The Committee believes
Mr.  Brewer's  compensation  is  consistent  with  the  special  demands  of the
position,  the compensation of chief executive  officers in the comparator group
and  in  accord  with  the  compensation   philosophy   articulated  above.  See
"Compensation  Philosophy-Annual  Incentive"  and  "Compensation Philosophy-Long
- -Term Incentive" above.

<PAGE>

Conclusion

         In summary, the Compensation Committee believes that, through the plans
and actions described above, a significant portion of the Company's compensation
program and, in particular, the program for executive officers, is contingent on
Company  performance,  and that the realization of benefits is closely linked to
achievement of key corporate objectives that will produce increases in long-term
stockholder  value. The Company remains  committed to this philosophy of pay for
performance,  recognizing that the Company is still in a developmental stage and
that the  competitive  market for talented  executives and the volatility of the
Company's business may result in highly variable compensation for any particular
time  period.  We  will  continue  to  monitor  closely  the  effectiveness  and
appropriateness  of each of the components of compensation to reflect changes in
the Company's business environment.

                                                    COMPENSATION COMMITTEE
                                                    Samuel H. Armacost, Chairman
                                                    Myron Du Bain
                                                    Eugene L. Step
                                                    Donald B. Rice
                                                    Charles A. Sanders






                                PERFORMANCE GRAPH

         The graph below assumes the investment of $100 in the Company's  Common
Stock, the NASDAQ Stock Market (U.S.) and the NASDAQ Pharmaceutical Stocks Index
on December 31, 1993. These comparator  indices were selected in 1992. The graph
below also includes the Russell 2000 Index and the Amex Biotechnology Index. The
Company believes these two indices each include  companies that are more similar
to the Company than the  companies  in the NASDAQ  Stock  Market  (U.S.) and the
NASDAQ  Pharmaceuticals  Stock Index. The stock price  performance  shown on the
graphs below is not necessarily indicative of future price performance.
<PAGE>

<TABLE>
<CAPTION>
                 Comparison of Five Year Cumulative Total Return
                  Among Scios Inc., NASDAQ Stock Market (U.S.),
             NASDAQ Pharmaceutical Stocks Index, Russell 2000 Index
                          and Amex Biotechnology Index

                              Nasdaq Stock        Nasdaq             Russell
     Dates       Scios Inc.   Market (U.S.)       Pharmaceuticals    2000             Amex Biotechnology
     -----       ---------    -------------       ---------------    -------          ------------------
     <S>         <C>          <C>                 <C>                <C>              <C>

     12/31/93    100.000      100.000             100.000            100.000          100.000
      1/31/94    101.351      118.281              91.842            103.067          104.733
      2/28/94     93.243      117.177              83.574            102.684           94.153
      3/31/94     79.730      109.971              72.698             97.088           79.478
      4/29/94     85.135      108.544              69.773             97.664           75.168
      5/31/94     72.297      108.809              68.831             96.399           81.085
      6/30/94     68.919      104.830              63.455             92.923           69.097
      7/29/94     68.919      106.980              65.375             94.381           68.647
      8/31/94     82.432      113.800              72.469             99.509           83.244
      9/30/94     72.973      113.509              71.469             99.045           78.606
     10/31/94     72.973      115.740              69.026             98.619           72.336
     11/30/94     64.865      111.900              69.331             94.455           73.329
     12/30/94     71.622      112.214              67.084             96.817           70.876
      1/31/95     83.784      112.843              70.798             95.460           69.874
      2/28/95     89.189      118.811              73.472             99.219           71.653
      3/31/95     82.432      122.334              72.422            100.843           66.989
      4/28/95     72.973      126.186              74.456            102.931           69.235
      5/31/95     38.514      129.442              75.395            104.509           67.162
      6/30/95     43.919      139.932              84.228            109.683           77.682
      7/31/95     45.946      150.218              91.480            115.906           84.306
      8/31/95     44.595      153.262             102.300            118.067           95.492
      9/29/95     44.595      156.787             105.244            120.028           98.627
     10/31/95     39.189      155.888             101.302            114.564           90.534
     11/30/95     41.892      159.549             106.385            119.332           94.084
     12/29/95     46.622      158.699             122.722            122.190          115.538
      1/31/96     58.108      159.482             133.452            121.961          124.633
      2/29/96     53.378      165.552             130.874            125.655          119.563
      3/29/96     49.324      166.101             127.685            127.913          116.454
      4/30/96     51.351      179.882             134.277            134.684          129.237
      5/31/96     79.054      188.141             138.823            139.932          134.436
      6/28/96     71.622      179.660             124.029            134.042          121.506
      7/31/96     60.811      163.658             110.568            122.201          100.346
      8/30/96     62.162      172.828             118.580            129.116          111.081
      9/30/96     66.892      186.048             126.865            133.953          120.936
     10/31/96     62.162      183.993             121.139            131.703          114.484
     11/29/96     62.162      195.367             119.411            136.939          116.480
     12/31/96     66.385      195.192             123.079            140.226          124.633
      1/31/97     64.189      209.064             133.429            142.871          143.488
      2/28/97     77.703      197.506             134.288            139.236          141.432
      3/31/97     73.649      184.612             116.886            132.472          120.522
      4/30/97     50.676      190.384             109.958            132.642          113.396
      5/30/97     68.243      211.969             126.527            147.245          128.537
      6/30/97     68.919      218.452             126.180            153.281          123.096
      7/31/97     86.486      241.510             129.780            160.285          119.218
      8/29/97     81.081      241.142             128.240            163.746          131.594
      9/30/97    105.405      255.404             141.556            175.498          152.470
     10/31/97     88.514      242.129             134.322            167.547          146.234
     11/28/97     81.757      243.326             130.203            166.256          142.918
     12/31/97    108.108      239.527             127.185            169.001          140.283
      1/31/98    102.703      246.649             126.277            166.306          135.982
      2/28/98    108.108      269.807             130.412            178.596          138.798
      3/31/98    131.757      279.772             140.149            185.885          150.769
      4/30/98    127.027      284.522             136.692            186.740          151.287
      5/31/98    101.351      268.906             131.989            176.581          139.290
      6/30/98     95.946      287.873             129.894            176.879          126.827
      7/31/98     82.432      284.833             131.016            162.323          119.174
      8/31/98     51.351      228.988             100.358            130.690           90.266
      9/30/98     61.486      260.615             122.918            140.605          120.392
     10/31/98     56.757      271.265             131.013            146.239          141.734
     11/30/98     81.757      297.988             137.381            153.815          141.328
     12/31/98    112.162      336.124             163.202            163.177          159.898
</TABLE>


         The graph below reflects the performance of the Company's  Common Stock
over calendar  years 1997 and 1998 (periods  which are also included in the five
year graph above) as compared to the new comparator indices described above. The
graph assumes the investment of $100 in the Company's  Common Stock, the Russell
2000 Index and the AMEX Biotechnology Index on December 31, 1996.

<TABLE>
<CAPTION>

                 Comparison of Two Year Cumulative Total Return
                    Among Scios Inc., Russell 2000 Index and
                            Amex Biotechnology Index

                                        Russell        Amex 
     Dates          Scios Inc.          2000           Biotechnology
     -----          ----------          -------        -------------
     <S>            <C>                 <C>            <C>
     12/31/96       100.000             100.000        100.000
      1/31/97        96.692             101.886        115.506
      2/28/97       117.048              99.294        113.851
      3/31/97       110.941              94.471         97.018
      4/30/97        76.336              94.592         91.282
      5/30/97       102.799             105.005        103.470
      6/30/97       103.817             109.310         99.090
      7/31/97       130.280             114.305         95.968
      8/29/97       122.137             116.773        105.932
      9/30/97       158.779             175.498        122.736
     10/31/97       133.333             167.547        117.716
     11/28/97       123.155             166.256        115.047
     12/31/97       162.850             169.001        112.926
      1/31/98       154.707             166.306        109.464
      2/28/98       162.850             178.596        111.730
      3/31/98       198.473             185.885        121.367
      4/30/98       191.349             186.740        121.784
      5/31/98       152.672             176.581        112.126
      6/30/98       144.529             176.879        102.094
      7/31/98       124.173             162.323         95.934
      8/31/98        77.354             130.690         72.663
      9/30/98        92.621             140.605         96.914
     10/31/98        85.496             146.239        114.094
     11/30/98       123.155             153.815        113.767
     12/31/98       168.957             163.177        128.716

</TABLE>

<PAGE>



                     CERTAIN RELATIONSHIPS AND TRANSACTIONS

         In 1993, the Company formed Guilford Pharmaceuticals Inc. ("Guilford").
Dr. Snyder is a director of Guilford.  Until  March 9, 1999,  the  Company owned
approximately 7% of the outstanding stock of Guilford.In March 1999, the Company
sold  substantially  all  of its holdings in Guilford, reducing its ownership to
less than 1% of Guilford's outstanding stock. During 1998, Guilford rented space
from the Company, for which it paid  $687,511.

         In 1998, in connection with the exercise of a stock option, the Company
extended a loan to Mr. Newman in the amount of $137,500. The loan bears interest
at the rate of 5.59% per annum and is  repayable  over four  years.  The current
balance is $103,125. Interest has been paid through March 3, 1999.

         In 1995,  Mr.  Feldman  received  a  relocation  loan in the  amount of
$275,000 to assist in his move to California  as part of the Company's  decision
to bring the management  offices for its commercial  operations  division to the
Company's  headquarters.  The loan is being forgiven over 5 years of employment.
$110,000 was outstanding under the loan as of March 16, 1999.

                                   PROPOSAL 2
                      RATIFICATION OF INDEPENDENT AUDITORS

         Upon  recommendation of the Audit Committee,  the Board of Directors of
the Company appointed PricewaterhouseCoopers LLP to be the Company's independent
auditors for the fiscal year ending December 31, 1999.

         Services   provided   to  the   Company   and   its   subsidiaries   by
PricewaterhouseCoopers  with respect to the fiscal year ended  December 31, 1998
included examination of the Company's consolidated financial statements, limited
reviews of  quarterly  reports,  services  related to filings  with the SEC, and
consultations concerning information systems and various tax matters.

         PricewaterhouseCoopers  has audited the Company's financial  statements
annually   since  the   Company's   inception   in  1982.   Representatives   of
PricewaterhouseCoopers are expected to be present at the Annual Meeting. They do
not  expect  to make a  statement,  but  will  have  the  opportunity  to make a
statement  if  they  desire  to do so  and  will  be  available  to  respond  to
appropriate questions.

         Stockholder ratification of the selection of  PricewaterhouseCoopers as
the Company's  independent  auditors is not required by the Company's  Bylaws or
otherwise.    However,    the   Board   is    submitting    the   selection   of
PricewaterhouseCoopers  to the stockholders for ratification as a matter of good
corporate practice. If the stockholders fail to ratify this selection, the Board
will  reconsider  whether or not to retain that firm.  Even if the  selection is
ratified,  the Board in its discretion may direct the appointment of a different
independent  accounting firm at any time during the year if the Board feels that
such  a  change  would  be  in  the  best  interests  of  the  Company  and  its
stockholders.

         Ratification  of  the  selection  of   PricewaterhouseCoopers   as  the
Company's independent auditors for fiscal year 1999 will require the affirmative
vote of at least a majority of the shares of Common Stock  represented in person
or by proxy and entitled to vote at the Annual Meeting.

The Board of Directors unanimously recommends a vote FOR Proposal 2.

<PAGE>

                                  OTHER MATTERS

         The Board of  Directors  does not know of other  matters  that may come
before the meeting.  However, if any other matters are properly presented to the
meeting,  it is the intention of the persons named in the accompanying  proxy to
vote, or otherwise to act, in accordance with their judgment on such matters.

                   STOCKHOLDER PROPOSALS - 2000 ANNUAL MEETING

         The deadline for submitting a stockholder proposal for inclusion in the
Company's  proxy  statement  and form of proxy  for the  Company's  2000  annual
meeting if  stockholders  pursuant to Rule 14a-8 of the  Securities and Exchange
Commission is December 2, 1999.



                                             By Order of the Board of Directors

                                             JOHN H. NEWMAN
                                             Secretary





March 31, 1999

THE BOARD OF DIRECTORS HOPE THAT STOCKHOLDERS WILL ATTEND THIS MEETING.  WHETHER
OR NOT YOU PLAN TO  ATTEND,  YOU ARE  URGED TO  COMPLETE,  SIGN AND  RETURN  THE
ENCLOSED PROXY IN THE ACCOMPANYING ENVELOPE. STOCKHOLDERS WHO ATTEND THE MEETING
MAY VOTE THEIR SHARES  PERSONALLY  EVEN THOUGH THEY HAVE SENT IN THEIR  PROXIES.
PLEASE NOTE,  HOWEVER,  THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK
OR OTHER  NOMINEE AND YOU WISH TO VOTE AT THE MEETING,  YOU MUST OBTAIN FROM THE
RECORD HOLDER A PROXY ISSUED IN YOUR NAME.


<PAGE>

                                   DETACH HERE


                                    SCIOS INC.

              PROXY FOR ANNUAL MEETING OF STOCKHOLDERS MAY 11, 1999
        
            THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

P  
R
O          The undersigned hereby appoints Richard B. Brewer and John H. Newman,
X     or  either  of  them,  each  with  full  power of substitution, as proxies
Y     of  the  undersigned,  to  attend  the  Annual  Meeting of Stockholders of
      Scios  Inc.,  to  be  held  at  the  offices of the Company, 2450 Bayshore
      Parkway,  Mountain View,  California, on  May 11, 1999 at 8:30 a.m. and at
      any  adjournment  or  postponement  thereof,  to vote the number of shares
      the  undersigned  would  be entitled to vote if personally present, and to
      vote  in  their  discretion upon any other business that may properly come
      before the meeting.

            THIS  PROXY  WHEN  PROPERLY  EXECUTED  WILL  BE  VOTED IN THE MANNER
      DIRECTED  HEREIN.  IF  NO  DIRECTION IS MADE, THIS PROXY WILL BE VOTED FOR
      PROPOSALS 1 AND 2.
 
            Please  sign,  date  and return this proxy in the envelope provided,
      which requires no postage if mailed in the United States.


                                                             ___________
                                                            
                                                             SEE REVERSE
             CONTINUED AND TO BE SIGNED ON REVERSE SIDE         SIDE
                                                             ___________





<PAGE>



                                 DETACH HERE

      PLEASE MARK
/ X / VOTES AS IN
      THIS EXAMPLE

- --------------------------------------------------------------------------------
         THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR PROPOSALS 1 AND 2.
- --------------------------------------------------------------------------------

1. Election of Directors.
NOMINEES: Samuel H. Armacost, Richard B. Brewer, Myron Du Bain, Donald B. Rice,
Charles A. Sanders, Solomon H. Snyder, Burton E. Sobel, Eugene L. Step

                        FOR           WITHHELD 
                        / /             / /

/ /  __________________________________________
     For all nominees except as noted above


 MARK HERE IF YOU PLAN TO ATTEND THE MEETING / /

 MARK HERE FOR ADDRESS CHANGE AND NOTE BELOW / /

2. To ratify the selection of PricewaterhouseCoopers
   LLP as the Company's Independent auditors for 
   fiscal 1999.                                       FOR    AGAINST   ABSTAIN
                                                      / /      / /       / /  

- --------------------------------------------------------------------------------

(Please sign exactly as name appears. When shares are held by joint tenants,
both should sign. When signing as attorney, as executor, administrator, 
trustee or guardian, please give full title as such. If a corporation, please 
sign in full corporate name by President or other authorized officer. If a 
partnership, please sign in partnership name by authorized person.)



Signature:________________ Date:________ Signature:_________________ Date:_____




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