SCIOS INC
DEFA14A, 2000-01-10
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                            SCHEDULE 14A INFORMATION

                Proxy Statement Pursuant to Section 14(a) of the
                Securities Exchange Act of 1934 (Amendment No. )

Filed by the Registrant /x/
Filed by a party other than the Registrant / /

Check the appropriate box:
/ / Preliminary Proxy Statement
/ /  Confidential,  for  Use  of the  Commission  Only  (as  permitted  by  Rule
     14a-6(e)(2))
/ / Definitive Proxy Statement
/ / Definitive  Additional Materials
/x/ Soliciting Material Pursuant to Section 240.14a-11(c) or Section
     240.14a-12

                                   Scios Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate  box):
/x/ No fee required
/ / Fee computed on table below per Exchange  Act Rules  14a-6(i)(1)
     and 0-11

(1) Title of each class of securities to which transaction applies:

- ------------------------------------------------------------------------

(2) Aggregate number of securities to which transaction applies:

- ------------------------------------------------------------------------

(3) Per unit price or other underlying value of transaction computed pursuant to
Exchange  Act Rule  0-11  (set  forth the  amount  on which  the  filing  fee is
calculated and state how it was determined):

- ------------------------------------------------------------------------

(4) Proposed maximum aggregate value of transaction:

- ------------------------------------------------------------------------

(5) Total fee paid:

- ------------------------------------------------------------------------

/ / Fee paid previously with preliminary materials.

/ / Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     (1) Amount Previously Paid:

     ------------------------------------------------------------------------

     (2) Form, Schedule or Registration Statement No.:

     ------------------------------------------------------------------------

     (3) Filing Party:

     -----------------------------------------------------------------------

     (4) Date Filed:

     ------------------------------------------------------------------------
<PAGE>


                               [SCIOS LETTERHEAD]

                                                                January 10, 2000

DEAR STOCKHOLDER:

     You may shortly  receive proxy  materials  from Randal J. Kirk seeking your
vote to elect  his  slate of hand  picked  nominees  to the  Scios  Board at our
upcoming  February 28 annual meeting.  Please do not return any proxy cards from
Mr.  Kirk.  In the next few weeks Scios will be mailing its own proxy  materials
with a GOLD  proxy  card  that  you  may use to vote  to  support  your  Board's
nominees.
                  DO NOT LET KIRK DERAIL OUR NEW BUSINESS PLAN
            SCIOS IS BACK ON TRACK TO DELIVER VALUE FOR STOCKHOLDERS

     Despite the obvious distractions of Kirk's proxy contest, Scios' management
will  remain  focused  on our new  business  plan  announced  in March  1999 and
developed  under the  guidance of the Board and Scios' new  Chairman,  new Chief
Executive  Officer and new Chief Financial  Officer,  each of whom assumed their
respective role in the fall of 1998.

     The top priority of our plan in 2000 is to take all necessary steps to best
ensure  the  success  of  the  key  product  in  our   pipeline,   Natrecor  (R)
(nesiritide).

     Scios, together with McKinsey & Co., a leading international consulting
     firm, completed a detailed study last august analyzing the potential market
     for Natrecor. Based on this study Scios estimates that Natrecor may achieve
     $200 to $300 million in annual sales in the U.S. within three to five
     years, once FDA approval is received. Our goal is to obtain FDA approval
     and introduce this product to the U.S. Market in 2001.

     We have begun a new Phase III clinical  trial for  Natrecor,  designed with
     the  assistance  of a blue ribbon  Steering  Committee of leading  heart
     failure physicians,  to  specifically  address the issues  raised by the
     FDA last April.  Patient enrollment and the training of additional
     qualified sites are proceeding on schedule.

     In the  last  six  months,  Scios  management  studied  the  best  means to
     commercialize  Natrecor for the  short-term  management  of acute
     decompensated Congestive  Heart Failure (aCHF).  One million people each
     year are hospitalized in the U.S. with aCHF. We determined that our optimum
     strategy would be to seek a partner to co-promote the product and
     discussions  with several new potential partners are already underway.

<PAGE>

     Scios'  other  key  product  is our  p38-kinase  inhibitor,  which  we have
targeted for the treatment of  rheumatoid  arthritis.  The Arthritis  Foundation
estimates that 2.1 million Americans suffer from rheumatoid  arthritis.  In 1999
we moved aggressively forward with our p38-kinase inhibitor program and our goal
remains to commence Phase I clinical trials in the second half of this year.

                       BUILDING VALUE THROUGH FOCUSED R&D

     Our  business  plan also calls for  building  value  through a more focused
Research  and  Development  effort  by  concentrating  on a  limited  number  of
discovery  research  programs which have the best market potential and by taking
advantage  of  licensing   and  royalty   opportunities.   Recently,   we  added
capabilities   in   functional   genomics,    high-throughput    screening   and
state-of-the-art  medicinal chemistry to our traditional  strengths in molecular
biology.

     With $100  million  of  cash-on-hand  and our  streamlined  operations,  we
believe we have the  financial  resources  to continue to develop new  compounds
with  strong  potential,  both  on our own and in  conjunction  with  commercial
partners. Activities in these areas include:

     The completion of a licensing  agreement for basic Fibroblast Growth Factor
     (FGF) with Chiron  Corporation,  which  includes $25 million in license
     fees and milestone payments.  Scios will also receive royalties from any
     form of FGF that Chiron markets. Chiron is currently in a Phase II trial of
     FGF for the treatment of coronary artery disease, which represents a
     significant revenue opportunity.

     Besides Chiron,  we are active partners with Eli Lilly and DuPont on
     Alzheimer's disease therapies,  with Novo Nordisk,  which is now
     conducting Phase I clinical trials of GLP-1 for diabetes,  and Kaken
     Pharmaceutical (NDA approval pending in Japan on the use of Fiblast(R) in
     wound healing).

                    MAJOR INSTITUTIONAL SHAREHOLDER DECLARES
                     SUPPORT FOR SCIOS BOARD AND MANAGEMENT

     John Nelson, Investment Director of The State of Wisconsin Investment Board
(SWIB),  sent a letter to the Board  dated  December  29,  which  states,  "SWIB
continues  to support  Scios  Board's  and  management's  efforts to realize the
potential  of the  company's  strong  product  pipeline.  We urge  the  Board to
continue their focus on the current strategy to maximize  long-term  shareholder
value.  We  believe  the  current  Board and  management  are the right  team to
                                                                  -----
accomplish this."

     SWIB  intends to vote for the  existing  Board slate and to reject the Kirk
nominees at our February 28 annual  meeting.  We are  gratified to have received
the  support  of the 1.6  million  shares  (4.3% of  Scios)  owned by one of our
largest, long-term institutional shareholders.  We urge you to join with SWIB in
supporting  your Board and  management by voting the GOLD proxy you will receive
later this  month.  A copy of the  Company's  press  release and the entire SWIB
letter follows.

<PAGE>

             SCIOS DOES NOT NEED KIRK, HIS NOMINEES OR HIS COMPANY

     We believe Mr. Kirk's motives in this contest are clear.  Kirk started this
proxy  contest  after he failed last fall to get your Board to agree to purchase
his private  company,  Lotus  Biochemical  -- which would have given him and his
co-investors a combined stake in Scios of about 22%.

     Now Kirk,  along  with his group of hand  picked  nominees,  seeks to seize
control of your Board and thereby your Company,  without paying you even a penny
for your  shares -- much less  paying  you a fair  premium.  Don't let Kirk gain
control of Scios' valuable scientific assets and its $100 million in cash.

     Remember -- Kirk owns 5.3% of Scios' shares,  accumulated just last summer
at an  average  price  of  about  $4 per  share.  We  think  Kirk  is  merely  a
"Johnny-come-lately"   opportunist   with   nothing  to  offer   Scios  and  its
stockholders.

                  YOU WILL RECEIVE SCIOS' PROXY MATERIALS SOON

     You do not have to take  any  action  with  respect  to Kirk at this  time.
Please wait for Scios' proxy  materials  and GOLD proxy card that will be mailed
about mid-January.

     We will keep you  informed as to further  developments  about our  business
plan and our clinical trials. We encourage you to visit the Company's website at
www.sciosinc.com.  For information  about the Year 2000 Annual  Meeting,  please
access the page www.sciosinc.com/election.

     We appreciate  your  continuing  support of Scios. If you have questions or
comments,  please call our investor  relations  department at (408)  616-8325 or
call MacKenzie Partners, Inc., toll-free at (800) 322-2885.

                      On Behalf of the Board of Directors

                                   Sincerely,

          DONALD B. RICE                RICHARD B. BREWER
          Chairman of the Board         President and Chief Executive Officer

<PAGE>

     The  statements  in  this  document  that  are  not  historical  facts  are
forward-looking statements that involve risks and uncertainties, and include the
risk of achieving approval and successful launch of Natrecor, and the timeliness
and success of Scios and its partners in developing other therapies, including a
p38-kinase  inhibitor,  as well as other risks detailed from time to time in the
reports filed by Scios with the SEC,  including  the Company's  annual report on
Form 10-K for the year ended  December 31, 1998 and  subsequent  reports on Form
10-Q.

                  CERTAIN INFORMATION CONCERNING PARTICIPANTS

     Scios Inc. has scheduled its annual  meeting of  stockholders  for February
28, 2000. The following  information is provided  concerning the participants on
behalf of Scios Inc. in the solicitation of proxies for this meeting.

     The following individuals,  all of whom are directors of Scios Inc., may be
deemed  participants  in the  solicitation of proxies on behalf of the Company's
Board of Directors: Donald B. Rice, Ph.D. (Chairman of the Board of the Company;
President and Chief Executive  Officer of Urogenesys,  Inc.);  Richard B. Brewer
(Chief  Executive  Officer and  President of the  Company);  Samuel H.  Armacost
(Chairman,  SRI  International);  Myron Du Bain  (Chairman  and Chief  Executive
Officer  (Retired),  Fireman's  Fund  Corporation);  Charles  A.  Sanders,  M.D.
(Chairman and Chief Executive Officer (Retired), Glaxo Inc.); Solomon H. Snyder,
M.D. (Director,  Department of Neuroscience, and Distinguished Service Professor
of Neuroscience,  Pharmacology and Molecular Sciences and Psychiatry,  The Johns
Hopkins  University);  Burton E. Sobel,  M.D. (E.L.  Amidon Professor and Chair,
Department  of Medicine,  The  University of Vermont  College of Medicine);  and
Eugene  L. Step  (Executive  Vice  President,  President  of the  Pharmaceutical
Division  (Retired),  Eli Lilly and Company).  The  following  executives of the
Company may also be deemed  participants:  Thomas L. Feldman (Vice  President of
Sales &  Marketing);  Elliott B.  Grossbard,  M.D.  (Senior  Vice  President  of
Development);  David W. Gryska (Vice  President  of Finance and Chief  Financial
Officer);  John A. Lewicki,  Ph.D. (Vice President of Research);  John H. Newman
(Senior Vice President, General Counsel & Secretary); George F. Schreiner, M.D.,
Ph.D. (Vice President,  Cardiorenal  Research) and Wendy Carhart (Senior Manager
of Investor Relations).

     In the aggregate,  these  individuals  beneficially own 1,654,411 shares of
the Company's Common Stock,  including 1,290,476 shares subject to stock options
exercisable  within 60 days of  December  31,  1999.  None of these  individuals
beneficially  owns more than 1% of the Company's  Common  Stock.  In addition to
customary  cash  compensation  payable  to  non-employee  directors,  under  the
Company's Equity Incentive Plan each non-employee director receives an automatic
grant of a stock option to acquire  10,000 shares of the Company's  Common Stock
at each annual  meeting where the director is elected to the Company's  Board of
Directors.  Mr.  Brewer's  employment  agreement with the Company  provides for,
among other things, severance payments to Mr. Brewer in the event of termination
of his employment "without cause" or "for good reason."

<PAGE>


                               [SCIOS LETTERHEAD]


CONTACT:
Wendy Carhart
Scios Inc.
408/616-8325
or
Stanley J. Kay
MacKenzie Partners, Inc.
212/929-5940

FOR IMMEDIATE RELEASE:

              MAJOR INSTITUTIONAL SHAREHOLDER DECLARES SUPPORT FOR
                   SCIOS BOARD AND MANAGEMENT IN PROXY CONTEST

SUNNYVALE,  CA, January 6, 2000 - Scios Inc. (NASDAQ: SCIO) announced today that
the State of Wisconsin  Investment Board (SWIB),  owner of 1.6 million shares of
Scios common stock,  has declared its continued  support for the existing  Scios
Board of Directors  and their  intention to reject the slate  proposed by Randal
J. Kirk at the Company's  Year 2000 Annual  Meeting  scheduled for February 28,
2000.

In a letter to the Scios Board of  Directors,  John  Nelson,  SWIB's  Investment
Director,  stated "SWIB  continues  to support  Scios  Board's and  management's
efforts to realize the potential of the Company's  strong product  pipeline.  We
urge the Board to  continue  their  focus on the  current  strategy  to maximize
long-term shareholder value. We believe the current Board and management are the
right team to accomplish this."
- -----

Richard B. Brewer, Scios' President and Chief Executive Officer,  stated "We are
gratified  to receive the strong  endorsement  of one of the  Company's  largest
long-term institutional shareholders."

Mr. Brewer continued: "In March of 1999 we announced a focused new business plan
and  initiated  steps to  dramatically  cut  costs.  Much has been  accomplished
despite  the  setback  for  Scios  and all  its  shareholders,  including  SWIB,
resulting from the FDA's decision on Natrecor (R) (nesiritide). We believe Scios
is now firmly back on track with the new Natrecor  clinical  trial,  guided by a
distinguished Steering Committee of leading physicians.  We believe the steps we
have taken in 1999 will  contribute to our goal of maximizing  Scios'  long-term
value for the benefit of all shareholders."

A copy of the letter sent from SWIB to the Scios Board of Directors is attached.

<PAGE>

SCIOS INC.

Scios is a biopharmaceutical company engaged in the discovery,  development, and
commercialization of novel human therapeutics.  Scios has commercial or research
and   development   relationships   with   Chiron   Corporation,    The   DuPont
Pharmaceuticals   Company,   Eli  Lilly  and   Company,   GenVec   Inc.,   Kaken
Pharmaceutical  Co., Ltd., and Novo Nordisk A/S of Denmark.  Scios'  Psychiatric
Sales and Marketing Division  successfully  markets seven psychiatric  products,
including co-promotion  arrangements with Janssen Pharmaceutica's  Risperdal(R)
(risperidone)  and SmithKline  Beecham's  Paxil(R)  (paroxetine  hydrochloride).
Additional  information  on  Scios  is  available  at its web  site  located  at
www.sciosinc.com  and in the Company's  various  filings with the Securities and
Exchange Commission.  For information about the Year 2000 Annual Meeting,  visit
www.sciosinc.com/election_information.

The  statements  in this  press  release  that  are  not  historical  facts  are
forward-looking statements that involve risks and uncertainties, and include the
risk of timely and  successful  completion  of the  current  clinical  trial for
Natrecor  and  achieving  approval  of  Natrecor,   the  risks  associated  with
development and  commercialization of the Company's other products and the risks
associated with the other strategies comprising the Company's new business plan,
as well as other risks  detailed from time to time in the reports filed by Scios
with the SEC,  including the  Company's  annual report on Form 10-K for the year
ended December 31, 1998 and subsequent reports on Form 10-Q.


<PAGE>


                   CERTAIN INFORMATION CONCERNING PARTICIPANTS

Scios Inc. has scheduled  its annual  meeting of  stockholders  for February 28,
2000. The following  information  is provided  concerning  the  participants  on
behalf of Scios Inc.  in the  solicitation  of  proxies  for this  meeting.

The  following  individuals,  all of whom are  directors  of Scios Inc.,  may be
deemed  participants  in the  solicitation of proxies on behalf of the Company's
Board of Directors: Donald B. Rice, Ph.D. (Chairman of the Board of the Company;
President and Chief Executive  Officer of Urogenesys,  Inc.);  Richard B. Brewer
(Chief  Executive  Officer and  President of the  Company);  Samuel H.  Armacost
(Chairman,  SRI  International);  Myron Du Bain  (Chairman  and Chief  Executive
Officer  (Retired),  Fireman's  Fund  Corporation);  Charles  A.  Sanders,  M.D.
(Chairman and Chief Executive Officer (Retired), Glaxo Inc.); Solomon H. Snyder,
M.D. (Director,  Department of Neuroscience, and Distinguished Service Professor
of Neuroscience,  Pharmacology and Molecular Sciences and Psychiatry,  The Johns
Hopkins  University);  Burton E. Sobel,  M.D. (E.L.  Amidon Professor and Chair,
Department  of Medicine,  The  University of Vermont  College of Medicine);  and
Eugene  L. Step  (Executive  Vice  President,  President  of the  Pharmaceutical
Division  (Retired),  Eli Lilly and Company).  The  following  executives of the
Company may also be deemed  participants:  Thomas L. Feldman (Vice  President of
Sales &  Marketing);  Elliott B.  Grossbard,  M.D.  (Senior  Vice  President  of
Development);  David W. Gryska (Vice  President  of Finance and Chief  Financial
Officer);  John A. Lewicki,  Ph.D. (Vice President of Research);  John H. Newman
(Senior Vice President, General Counsel & Secretary); George F. Schreiner, M.D.,
Ph.D. (Vice President,  Cardiorenal  Research) and Wendy Carhart (Senior Manager
of Investor Relations).

In the aggregate,  these  individuals  beneficially  own 1,654,411 shares of the
Company's  Common Stock,  including  1,290,476  shares  subject to stock options
exercisable  within 60 days of  December  31,  1999.  None of these  individuals
beneficially  owns more than 1% of the Company's  Common  Stock.  In addition to
customary  cash  compensation  payable  to  non-employee  directors,  under  the
Company's Equity Incentive Plan each non-employee director receives an automatic
grant of a stock option to acquire  10,000 shares of the Company's  Common Stock
at each annual  meeting where the director is elected to the Company's  Board of
Directors.  Mr.  Brewer's  employment  agreement with the Company  provides for,
among other things, severance payments to Mr. Brewer in the event of termination
of his employment "without cause" or "for good reason."


<PAGE>

                [STATE OF WISCONSIN INVESTMENT BOARD LETTERHEAD]

29 December 1999

Board of Directors
Scios, Inc.
820 West Maude Avenue
Sunnyvale, CA  94086

Re:  Intention  to vote for  existing  Board of  Directors  and  reject The Kirk
Stockholders' alternative slate of Directors.

Dear Board of Directors' Members:

The State of Wisconsin  Investment Board (SWIB) intends to vote for the existing
Board of Directors  slate for the 2000 Scios annual meeting.  In addition,  SWIB
intends  to reject The Kirk  Stockholders'  alternative  slate of Board  members
being proposed. SWIB owns 1,590,500 shares or 4.2% of Scios outstanding shares.

SWIB continues to support Scios Board's and management's  efforts to realize the
potential  of the  company's  strong  product  pipeline.  We urge  the  Board to
continue their focus on the current strategy to maximize  long-term  shareholder
value.  We  believe  the  current  Board and management are the right  team to
                                                                -----
accomplish this.

Sincerely,

/s/

John F. Nelson
Investment Director





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