SCIOS INC
PRER14A, 2000-01-13
PHARMACEUTICAL PREPARATIONS
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                                   Scios Inc.
                              820 West Maude Avenue
                               Sunnyvale, CA 94086
                             _____________________


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                                February 28, 2000
                                    9:00 a.m.


To the Stockholders:


NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders of Scios Inc., a
Delaware  corporation  (the  "Company"),  will be held at the  Company's  office
located at 749 North Mary Avenue,  Sunnyvale,  California 94086, at 9:00 a.m. on
February 28, 2000, to consider and act upon the following matters:


     (1) To elect  directors  of the Company to serve for the ensuing  year and
until their successors are elected.

     (2)  To  ratify  the  selection  of  PricewaterhouseCoopers  LLP as the
Company's independent auditors for fiscal 2000.

     (3)      To act upon such other matters that may properly come before the
meeting or any adjournment or postponement of the meeting.

     The  foregoing  items of  business  are more fully  described  in the proxy
statement  accompanying this notice. Only stockholders of record at the close of
business  on January  11, 2000 will be entitled to notice of and to vote at this
meeting and any adjournment or postponement  thereof.  For ten days prior to the
meeting, a complete list of stockholders entitled to vote at the meeting will be
available  for  examination  by any  stockholder  for  purposes  relating to the
meeting,  during ordinary  business hours at the Company's office located at 749
North Mary Avenue, Sunnyvale, California 94086.

                                 By Order of the Board of Directors

                                 JOHN H. NEWMAN
                                 Secretary


Sunnyvale, California
January [__], 2000

ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.  WHETHER
OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE,  DATE, SIGN AND RETURN
THE  ENCLOSED  GOLD  PROXY AS  PROMPTLY  AS  POSSIBLE  IN ORDER TO  ENSURE  YOUR
REPRESENTATION  AT THE MEETING.  A RETURN ENVELOPE (WHICH IS POSTAGE PRE-PAID IF
MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE.

THE BOARD OF DIRECTORS URGES YOU NOT TO SIGN ANY WHITE PROXY CARD SENT TO YOU BY
THE KIRK GROUP.  IF YOU HAVE  ALREADY  DONE SO, YOU MAY REVOKE  YOUR  PREVIOUSLY
SIGNED WHITE PROXY BY DELIVERING A WRITTEN NOTICE OF REVOCATION OR A LATER DATED
GOLD PROXY CARD IN THE ENCLOSED ENVELOPE. EVEN IF YOU HAVE GIVEN YOUR PROXY, YOU
MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING.  PLEASE NOTE, HOWEVER,  THAT
IF YOUR  SHARES ARE HELD OF RECORD BY A BROKER,  BANK OR OTHER  NOMINEE  AND YOU
WISH TO VOTE AT THE  MEETING,  YOU MUST  OBTAIN  FROM THE RECORD  HOLDER A PROXY
ISSUED IN YOUR NAME.



<PAGE>


                                   Scios Inc.
                              820 West Maude Avenue
                           Sunnyvale, California 94086
                             _____________________

                                 Proxy Statement
                         Annual Meeting of Stockholders
                                February 28, 2000

General


     The  enclosed  proxy is  solicited  on behalf of the Board of  Directors of
Scios Inc., a Delaware  corporation  (the "Company" or "Scios"),  for use at its
Annual Meeting of Stockholders to be held at the Company's office located at 749
North Mary  Avenue,  Sunnyvale,  California  94086 at 9:00 a.m. on February  28,
2000, and at any adjournment or  postponement of that meeting,  for the purposes
set  forth  herein  and  in the  accompanying  Notice  of  Annual  Meeting.  The
approximate  mailing date for this Proxy  Statement  and the  enclosed  proxy is
January [__], 2000.

     The Board of Directors  has fixed the close of business on January 11, 2000
as the record date for the determination of stockholders entitled to vote at the
Annual  Meeting.  At that time,  there were  38,468,652  shares of Common  Stock
issued and outstanding (not including any treasury shares).

Voting

     Each share of Common  Stock  issued and  outstanding  on the record date is
entitled  to one vote.  In the  election  of  directors,  the  seven  candidates
receiving  the highest  number of  affirmative  votes of the shares  present and
voting at the  Annual  Meeting  at which a quorum  is  present  will be  elected
directors.  See  "Nominations  by the Kirk  Group"  below.  With  respect to the
election  of  directors,  where  no vote is  specified  on a  proxy,  the  votes
represented  by the GOLD  proxy  card  will be cast,  at the  discretion  of the
proxies  named  therein,  for all the  candidates  nominated  by the  Board.  An
affirmative  vote of a majority of the shares  present and voting at the meeting
is generally  required for approval of any other items properly submitted to the
stockholders for their consideration.


     The  presence at the Annual  Meeting in person or by proxy of a majority of
the  shares  outstanding  as of  the  record  date  will  constitute  a  quorum.
Abstentions and broker  non-votes are counted towards a quorum.  Abstentions are
counted in tabulations of the votes cast on proposals  presented to stockholders
and have the effect of negative votes,  whereas broker non-votes are not counted
for any purpose in determining whether a proposal has been approved.

Revocability of Proxies

     Any person giving a proxy in the form accompanying this Proxy Statement has
the power to revoke it at any time  before  its  exercise.  It may be revoked by
filing with the  Secretary of the Company an  instrument of revocation or a duly
executed  proxy  bearing a later date.  It also may be revoked by attending  the
meeting and voting in person. Attendance at the meeting will not itself revoke a
proxy.

Solicitation of Proxies

     Solicitation  of  proxies  may be made by  directors,  officers  and  other
employees of the Company named on Appendix A by personal  interview,  telephone,
telegraph, telefax or electronic communications. No additional compensation will
be paid  for any  such  services.  Costs  of  solicitation  will be borne by the
Company.  Upon  request,  the Company will  reimburse  the  reasonable  fees and
expenses  of  banks,  brokerage  houses or other  nominees  or  fiduciaries  for
forwarding proxy materials to, and obtaining  authority to execute proxies from,
beneficial owners for whose accounts they hold shares of Common Stock.


     The Company has retained MacKenzie Partners,  Inc.  ("MacKenzie") to assist
in the  solicitation  of  proxies.  Pursuant  to the  Company's  agreement  with
MacKenzie,  it will provide various proxy advisory and solicitation services for
the  Company  at a  fee  estimated  not  to  exceed  $125,000,  plus  reasonable
out-of-pocket  expenses and indemnification  against certain liabilities.  It is
expected that MacKenzie will use approximately 35 persons in such solicitation.


<PAGE>

     Certain information concerning the directors,  officers and other employees
of the Company who may solicit  proxies is attached to this Proxy  Statement  as
Appendix A. Certain information  concerning the Common Stock held by the persons
listed  in  Appendix  A and  certain  transactions  between  any of them and the
Company is set forth in Appendix B.


     Although  no  precise  estimate  can be  made  at this  time,  the  Company
anticipates  that the aggregate  amount to be spent by the Company in connection
with the solicitation of proxies by the Company will be approximately  $625,000,
of which approximately  $205,000 has been incurred to date. This amount includes
the fees  payable to  MacKenzie  but  excludes  (i) the salaries and expenses of
officers,  directors, and employees of the Company; and (ii) the normal expenses
of an uncontested election. The aggregate amount to be spent will vary depending
on, among other  things,  any  developments  that may occur in the proxy contest
described below.


     Please  complete,  date and sign the enclosed GOLD proxy card and return it
promptly in the  envelope  provided.  If your shares are held in "street  name,"
only your  bank or  broker  can vote  your  shares  and only upon your  specific
instructions.  Please  contact  the  person  responsible  for your  account  and
instruct him or her to vote the GOLD proxy card as soon as possible.


     The Board of  Directors  urges you NOT TO SIGN any WHITE proxy card sent to
you by the Kirk Group.  See  "Nominations  by the Kirk Group" below. If you have
already done so, you may revoke your previously signed WHITE proxy by delivering
a written  notice of revocation or a later dated GOLD proxy card in the enclosed
envelope.


<PAGE>

                          NOMINATIONS BY THE KIRK GROUP


     In a letter  dated  December 2, 1999 (the "Kirk Group  Notice"),  Randal J.
Kirk,  and certain  entities  (the "Kirk  Group")  notified  the Company that it
intended to nominate eight individuals for election to the Board. The Kirk Group
consists of Mr. Kirk and each of the  following  entities that Mr. Kirk directly
controls:  RJK, LLC, a Virginia limited  liability  company,  Kirkfield,  LLC, a
Virginia limited liability company, and The Kirk Family Investment Plan, a joint
account.  Mr.  Kirk has filed the Kirk  Group  Notice  with the  Securities  and
Exchange  Commission  in an amendment to a Schedule 13D dated  December 3, 1999.
That Schedule 13D contains his information regarding his nominees.

     The Board is convinced that the election of new directors  nominated by the
Kirk Group would run directly  counter to the best  interests  of the  Company's
stockholders. The Board is intimately familiar with the Company and the industry
in which it operates.  The Board is fully committed to maximizing  value for all
of the Company's  stockholders;  and the Company has made significant strides in
restructuring  its business  since the hiring of Richard Brewer as President and
CEO in September  1998.  The Board  believes  that a change in the Board at this
time would be highly disruptive to the strategy the Company is actively pursuing
and could raise significant  concerns with current and future business partners,
and that  uncertainties  arising  from such a change could result in the loss of
key  personnel,  who are unique and  important  assets to the  Company,  thereby
disrupting or delaying  completion of the important  Natrecor(R)  clinical trial
now underway.


     The Company is not responsible for the accuracy of any information provided
by or relating to the Kirk Group contained in its notice to the Company,  in any
proxy  materials  filed or disseminated by the Kirk Group or any other statement
it may make.

     THE BOARD OF DIRECTORS  UNANIMOUSLY  RECOMMENDS THAT  STOCKHOLDERS  VOTE IN
FAVOR OF THE NOMINEES OF THE BOARD DESCRIBED IN PROPOSAL 1 BELOW AND NOT VOTE IN
FAVOR OF THE NOMINEES OF THE KIRK GROUP.


                                   PROPOSAL 1
                              ELECTION OF DIRECTORS


     As noted below, Myron Du Bain is retiring as a Director of the Company upon
the election of the Board at the Annual  Meeting.  Accordingly,  pursuant to the
procedure set forth in the Company's Certificate of Incorporation, the number of
Directors  of the  Company  has been  reduced  from  eight  to  seven  effective
immediately  prior to the  election  of  directors  at the  Annual  Meeting  and
accordingly a Board of seven (7) Directors  will be elected.  The term of office
of each  person so elected as a Director  will  continue  until the next  annual
meeting or until a successor has been elected. Unless otherwise instructed,  the
proxy  holders  will vote the GOLD proxy  cards  received  by them for the seven
nominees  of the  Board of  Directors  named  below,  all of whom are  presently
Directors of the Company.  The candidates  receiving a plurality of the votes of
the shares present in person or represented by proxy at the meeting and entitled
to vote will be elected.  Each person nominated for election has agreed to serve
if elected,  and  management  has no reason to believe  that any nominee will be
unable to serve. Stockholders who desire to nominate persons for election to the
Board must comply with the advance notice procedures  specified in the Company's
Bylaws.


     The following is information regarding the nominees,  including information
furnished  by them as to their  principal  occupation  for the past five  years,
certain directorships and their ages as of December 31, 1999.

<TABLE>
<CAPTION>
                                                                                        Director
                  Name                               Age                                Since
                  ----                               ---                                -----

        <S>                                         <C>                                <C>
         Samuel H. Armacost                          60                                 1995
         Richard B. Brewer                           48                                 1998
         Donald B. Rice, Ph.D.                       60                                 1997
         Charles A. Sanders, M.D.                    67                                 1997
         Solomon H. Snyder, M.D.                     61                                 1992
         Burton E. Sobel, M.D.                       62                                 1996
         Eugene L. Step                              70                                 1993
</TABLE>
<PAGE>


     Mr.  Armacost  was elected to the  Company's  Board of  Directors in August
1995. In July 1998, Mr.  Armacost  became  Chairman of the Board of Directors of
SRI International.  From 1990 to 1998, he was a Managing Director of Weiss, Peck
& Greer,  LLC, an investment  firm. He was a Managing  Director of Merrill Lynch
Capital Markets from 1987 to August 1990, and was President,  Director and Chief
Executive Officer of BankAmerica  Corporation from 1981 to 1986. Mr. Armacost is
a member of the Board of Directors of Chevron Corporation and Exponent,  Inc. In
addition,  Mr.  Armacost  is on the  Board  of  Directors  of the  James  Irvine
Foundation and the Advisory Board of the California Academy of Sciences,  and he
is a member of the International  Advisory Group for Toshiba Corporation and The
Business Council.


     Mr. Brewer is President and Chief Executive Officer of Scios Inc. He joined
Scios in September 1998 and has served as a Director since that time. From early
1996 to 1998, he was with Heartport  Inc.,  first as Executive Vice President of
Operations and then, Chief Operating  Officer.  Prior to that, Mr. Brewer served
in various  capacities with Genentech,  Inc. from 1984 to 1995, most recently as
Senior Vice  President,  U.S.  Sales and Marketing,  Genentech  Europe Ltd., and
Genentech  Canada,  Inc. Mr.  Brewer  earned a B.S.  from  Virginia  Polytechnic
Institute and a M.B.A. from Northwestern University.

     Dr. Rice was elected  Chairman of the Board in November 1998 and has served
as a Director of Scios since  August  1997.  Dr.  Rice is the  President,  Chief
Executive  Officer  and  Director  of  UroGenesys,  Inc.  Previously,  he served
Teledyne,  Inc. as President,  Chief Operating Officer and Director from 1993 to
1996, the U.S.  Department of Defense as Secretary of the Air Force from 1989 to
1993,  and The RAND  Corporation as President and Chief  Executive  Officer from
1972 to 1989. He was also  Assistant  Director of the Office of  Management  and
Budget, The White House. Dr. Rice is a member of the Board of Directors of Wells
Fargo & Company, Vulcan Materials Company and Unocal Corporation.

     Dr. Sanders was elected a Director of Scios in September 1997. He served as
Chief Executive Officer of Glaxo Inc. from 1989 to 1994, and was Chairman of the
Board from 1992 to 1995.  He also served on the Board of Directors of Glaxo plc.
Previously, he held a number of positions at Squibb Corporation, a multinational
pharmaceutical corporation,  including Vice Chairman, Chief Executive Officer of
the  Science and  Technology  Group and  Chairman of the Science and  Technology
Committee  of the Board.  Dr.  Sanders is a member of the Board of  Directors of
Magainin  Pharmaceuticals,  Vertex  Pharmaceuticals,  Staff Mark,  Inc.,  Kendle
International, Trimeris, Pharmacopeia, Genentech, Inc. and Biopure.

     Dr. Snyder was elected a Director in September 1992. Dr. Snyder is Director
of the  Department  of  Neuroscience  and  Distinguished  Service  Professor  of
Neuroscience,  Pharmacology  and Molecular  Sciences and Psychiatry at The Johns
Hopkins  University,  and has been a member of the faculty there since 1966. Dr.
Snyder  received  the Albert  Lasker  Award for Basic  Biomedical  Research  and
Honorary  Doctor of Science  degrees from  Northwestern  University,  Georgetown
University  and Ben Gurion  University.  Dr. Snyder  received the Wolfe Award in
Medicine from the government of Israel for research  relating to receptors.  Dr.
Snyder is a member  of the  National  Academy  of  Sciences  and a Fellow of the
American Academy of Arts and Sciences. Dr. Snyder is also the author of numerous
articles and several  books.  Dr. Snyder is a founder and a director of Guilford
Pharmaceuticals Inc.


     Dr.  Sobel  was  elected  a  Director  in  February   1996.  Dr.  Sobel  is
Physician-in-Chief,  E.L.  Amidon  Professor  and  Chair  of the  Department  of
Medicine at The University of Vermont College of Medicine. Previously, Dr. Sobel
was Professor of Medicine at Barnes Hospital, Washington University and Director
of its Cardiovascular Division. Dr. Sobel has been a consultant to and served on
scientific   advisory  boards  of  several   pharmaceutical   and  biotechnology
companies,  served as a director of Squibb  Corporation from 1986 to 1989 and is
also a member of the Board of Directors of Fletcher Allen Healthcare.  Dr. Sobel
has  been the  recipient  of  numerous  awards,  including  the  American  Heart
Association's James B. Herrick Award and its Scientific Council's  Distinguished
Achievement Award, as well as the American College of Cardiology's Distinguished
Scientist  Award.  Dr. Sobel has been the editor of Circulation and, since 1989,
has served as editor of Coronary Artery Disease. His memberships and fellowships
include the American College of Physicians,  Royal Society of Medicine, American
Heart  Association,  American  College of Cardiology  and Fellowship and Council
membership in the American Association for the Advancement of Science.


     Mr. Step was elected a Director  in February  1993.  From May 1956 until he
retired in December 1992,  Mr. Step was employed by Eli Lilly and Company,  most
recently as Executive Vice President,  President of the Pharmaceutical Division,
where  he was  responsible  for  U.S.  pharmaceutical  operations  and  for  the
operations  of Eli Lilly  International.

<PAGE>

In addition,  Mr. Step served on Eli Lilly's  Board of Directors  and  executive
committee. Mr. Step was Chairman of the Board of Directors of the Pharmaceutical
Manufacturers  Association  and  President of the  International  Federation  of
Pharmaceutical  Manufacturers  Associations.  He is a  member  of the  Board  of
Directors  of Cell Genesys  Inc.,  Guidant  Corporation,  Medco  Research  Inc.,
Pathogenesis Corporation and DBT Online Inc.

     In accordance with his longstanding personal plans, Myron Du Bain (age 76),
a director  of the  Company  since  1989,  will  retire  from the Board upon the
election  of the new  slate  of  directors  at the  Annual  Meeting.  The  Board
sincerely  thanks Mr. Du Bain for the guidance and wisdom he has provided to the
Company.

                  INFORMATION ABOUT THE BOARD OF DIRECTORS AND
                             COMMITTEES OF THE BOARD

Compensation of Directors

     General.

     Fees.  Directors who are not otherwise  employed by the Company  receive an
annual retainer of $8,000 and a fee of $1,000 per day for attendance at meetings
of the Board of Directors or committee  meetings,  and $500 for  attendance at a
telephonic  meeting.  Directors are also eligible for  reimbursement of expenses
incurred in  connection  with  attendance at Board  meetings in accordance  with
Company policy.

     Stock Options.  In May 1998, the  stockholders  of the Company  approved an
amendment of the Company's  1992 Equity  Incentive  Plan (the "Equity  Plan") to
provide that each non-employee  Director shall automatically be granted, at each
annual  meeting  where  the  Director  is  elected  to the  Company's  Board,  a
supplemental  stock option to purchase  10,000  shares of the  Company's  Common
Stock.  Such options are granted with exercise  prices equal to the current full
market price. Only non-employee Directors of the Company are eligible to receive
options under the applicable  provisions of the Equity Plan,  and Mr.  Armacost,
Mr. Du Bain, Dr. Rice,  Dr.  Sanders,  Dr.  Snyder,  Dr. Sobel and Mr. Step each
received an automatic  option grant at the time of  re-election  to the Board in
May 1999.


     Board of  Directors.  During  1999,  there were 12 meetings of the Board of
Directors and 10 meetings of the various committees.


     Chairman of the Board.  On November 9, 1999,  Donald B. Rice was re-elected
Chairman of the Board, a nonexecutive position, and for serving in this role the
Board awarded Dr. Rice additional cash  compensation of $7,500 per quarter and a
supplemental  stock option to purchase  15,000  shares of the  Company's  Common
Stock at the then current market price.


     Audit  Committee.   The  Audit  Committee  consists  of  four  non-employee
Directors:  Mr. Step (Chairman),  Mr.  Armacost,  Dr. Sanders and Dr. Sobel. The
Audit  Committee  met four times in 1999.  Among the  committee's  functions are
recommending  engagement  of  the  Company's  independent  auditors,   approving
services performed by such auditors, and reviewing and evaluating the Company's
accounting systems and its system of internal accounting controls.



     Management   Development  and   Compensation   Committee.   The  Management
Development and Compensation Committee consists of five non-employee  Directors:
Mr.  Armacost  (Chairman),  Mr. Du Bain, Dr. Rice, Dr. Sanders and Mr. Step. The
committee  met five times  during  1999.  Among the  committee's  functions  are
establishing the Company's  compensation programs for all employees,  fixing the
compensation levels of executive officers of the Company,  and administering and
making awards under the Company's incentive programs.


     Nominating   Committee.   The  Nominating   Committee   consists  of  three
non-employee  Directors:  Mr. Du Bain (Chairman),  Dr. Rice and Dr. Snyder.  The
committee  met one time in fiscal  1999.  Among the  committee's  functions  are
recommending nominees to serve on the Board of Directors,  recommending the size
and composition of the Board, making  recommendations  concerning  membership of
Board  committees and Director  compensation,  and consulting  with the Board of
Directors and management to determine  criteria for nominations.  The Nominating
Committee will consider nominees recommended by stockholders.

<PAGE>


         In 1999,  all  Directors  attended at least 75% of the  meetings of the
Board and Committees of the Board of which they were members, with the exception
of Dr.  Sanders,  who attended 8 of 12 meetings of the Board and 6 of 9 meetings
of Committees of the Board of which he was a member.



           SECURITY OWNERSHIP OF MANAGEMENT AND PRINCIPAL STOCKHOLDERS

                              Beneficial Ownership

     The following table sets forth certain information regarding the beneficial
ownership of the Company's Common Stock at December 31, 1999, by (i) all persons
known by the  Company  to be  beneficial  owners of more  than 5% of its  Common
Stock,  (ii) each  Director,  (iii) each of the executive  officers named in the
Summary  Compensation Table included herein and (iv) all Directors and executive
officers of the Company as a group.

<TABLE>
<CAPTION>
                                                              Beneficial Ownership(1)
                                                              -----------------------

                                                       Beneficially                  Approximate
Officers, Directors &                                      Owned                       Percent
5% Stockholders                                           Shares(2)                    of Class
- ---------------                                           ---------                    --------
<S>                                                   <C>                             <C>



Samuel H. Armacost                                        60,500                        *
Richard B. Brewer                                        285,000                        *
Myron Du Bain                                             63,500(3)                     *
Donald B. Rice, Ph.D.                                     66,250                        *
Charles A. Sanders, M.D.                                  27,166                        *
Solomon H. Snyder, M.D.                                   42,333                        *
Burton E. Sobel, M.D.                                     33,500                        *
Eugene L. Step                                            42,500                        *
Elliott B. Grossbard, M.D.                               291,865                        *
David W. Gryska                                           69,666                        *
John A. Lewicki, Ph.D.                                   222,773                        *
John H. Newman                                           272,173(3)                     *

All officers and directors as a
   group (12 persons)                                  1,477,226                       3.8%

Randal J. Kirk(4)
   Third Security LLC
   The Governor Tyler
   Radford, VA  24141                                 2,000,000                        5.2%


<FN>
- ---------
* less than 1%

(1)  Unless  otherwise  indicated below and subject to community  property laws,
     each  stockholder has sole voting and investment  power with respect to the
     shares beneficially owned.

(2)  For Mr.  Armacost,  Mr. Brewer,  Mr. Du Bain, Dr. Rice,  Dr.  Sanders,  Dr.
     Snyder,  Dr. Sobel, Mr. Step, Dr. Grossbard,  Mr. Gryska,  Mr. Newman,  Dr.
     Lewicki,  and all  officers  and  directors  as a group,  includes  35,500;
     180,000;  33,500; 46,250; 27,166; 22,333; 33,500; 41,500; 284,081;  29,166;
     178,123;  204,872;  and  1,115,991  shares,  respectively,   issuable  upon
     exercise of outstanding  options  exercisable within sixty days of December
     31, 1999.

(3)  With  respect to Mr. Du Bain,  includes  25,000  shares held in a revocable
     living trust for the benefit of Mr. Du Bain and his wife;  Mr. Du Bain is a
     trustee of such trust.  With respect to Mr.  Newman,  includes 7,000 shares
     held in his  spouse's  IRA account and 2,000 shares held for the benefit of
     Mr. Newman's children.

<PAGE>

(4)  Based solely on information contained in a Schedule 13D dated July 3, 1999,
     and includes 387,000 shares reported to be beneficially  owned by RJK, LLC,
     225,000  shares  reported to be  beneficially  owned by Kirkfield  LLC, and
     251,400  shares  reported  to be  beneficially  owned  by The  Kirk  Family
     Investment Plan.
</FN>
</TABLE>


     There are no family relationships between any of the Directors or executive
officers of the Company.  The Company is not aware of any material proceeding to
which any Director or executive  officer of the Company or any  associate of any
such  Director or executive  officer is a party adverse to the Company or any of
its subsidiaries or has a material interest adverse to the Company or any of its
subsidiaries.

Compliance With Section 16(A) of the Exchange Act

     Section  16(a) of the  Securities  Exchange  Act of 1934,  as amended  (the
"Exchange  Act"),  requires  the  Company's  Directors,  executive  officers and
holders of more than ten  percent  (10%) of the  Company's  Common  Stock  ("10%
Holders")  to file with the  Securities  and  Exchange  Commission  (the  "SEC")
initial reports of ownership and reports of changes in ownership of Common Stock
and other equity securities of the Company.  Directors,  executive  officers and
10% Holders are required by SEC regulation to furnish the Company with copies of
all Section 16(a) forms they file.

     Based  solely on its review of the copies of such forms  received by it, or
written  representations  from  certain  reporting  persons that no Forms 5 were
required for those persons,  the Company believes that during 1999 its officers,
directors  and greater  than ten percent  beneficial  owners  complied  with all
applicable filing requirements.

<PAGE>

                             EXECUTIVE COMPENSATION

     The following table discloses  compensation received by the Company's Chief
Executive Officer and each of its four other most highly  compensated  executive
officers at December 31, 1999 for the fiscal years ended December 31, 1999, 1998
and 1997.

<TABLE>
<CAPTION>

                           SUMMARY COMPENSATION TABLE

                                                                                Long-Term
                                                                                Compensation
                                      Annual Compensation                       Awards
                                      -------------------                       ------

Name                                                                                    Securities
and                                                                     Restricted      Underlying        All Other
Principal                                                               Stock           Stock             Compensa-
Position                      Year        Salary ($)     Bonus (1)($)   Award (2)($)    Options(#)        sation (3)($)
- --------                      ----        ----------     ------------   ------------    ----------        -------------
<S>                          <C>         <C>            <C>             <C>            <C>               <C>


Richard B. Brewer             1999        $400,000       $200,000           --            200,000           $4,538
   President and Chief        1998        $103,000(4)    $ 50,000        $596,775         275,000           $3,000
   Executive Officer          1997            N/A

Elliott B. Grossbard, M.D.    1999        $270,000          --              --             40,000           $3,000
   Senior Vice President      1998        $260,000       $100,000           --             68,500           $3,000
   of Development             1997        $246,064          --              --             19,000           $3,000

David W. Gryska               1999        $195,000       $ 60,000        $152,460           --              $3,000
   Vice President of Finance  1998        $  8,860(5)    $  5,000           --            100,000             --
   and Chief Financial Officer1997            N/A

John A. Lewicki, Ph.D.        1999        $230,000       $ 20,000           --             20,000          $13,553
   Vice President             1998        $222,000       $ 50,000           --             50,000           $3,000
   of Research                1997        $222,000          --              --             12,000           $3,000

John H. Newman                1999        $228,000       $ 47,500           --             20,000           $8,923
   Senior Vice President,     1998        $220,000       $ 50,000           --             53,500           $3,000
   General Counsel &          1997        $212,500          --              --             19,000           $3,000
   Secretary

<FN>
- ---------------

(1)  Bonus amounts  represent  the value of awards under the Company's  Employee
     Incentive Plan. Awards to executive officers under this plan are determined
     annually by the Management  Development  and  Compensation  Committee.  The
     bonus  to  Mr.  Brewer  is the  minimum  provided  for  in  his  employment
     agreement.  In addition,  the 1999 amount for Mr. Gryska  includes a $5,000
     award under the Company's Spot Bonus Award program to recognize his role in
     the sale of the Company's Mountain View real estate.

(2)   Mr.  Brewer  received  100,000  shares of Common Stock valued on the grant
      date at $5.96875 per share upon  becoming  President  and Chief  Executive
      Officer (See Note 4). 50% of the shares vested on the first anniversary of
      his employment  (September 9, 1999)  triggering an income tax  withholding
      obligation of  $73,206.25  which Mr. Brewer has paid and 50% of the shares
      will vest on the second  anniversary of his employment  with a similar tax
      obligation due from Mr. Brewer at that time.  The aggregate  value of such
      shares on December 31, 1999 was $418,750.  Mr. Gryska,  the Company's Vice
      President of Finance and Chief Financial  Officer,  received 40,000 shares
      of Common Stock valued on the grant date at $3.8125 per share.  25% of the
      shares  vest on  August 9,  2000 and 75% of the  shares  vest on August 9,
      2002.  The  aggregate  value  of such  shares  on  December  31,  1999 was
      $167,500.  No  dividends  will be paid by the Company  with respect to the
      restricted stock awards.

<PAGE>

(3)   Consists of Company matching contributions under the 401(k) Profit Sharing
      Plan and Trust,  which was  established  in 1986 and unused  vacation time
      redeemed  for cash (Mr.  Brewer,  $1,538;  Dr.  Lewicki,  $10,553  and Mr.
      Newman,  $5,923).  As of December  31,  1999,  the Company  made  matching
      contributions  of 100% of  participant  contributions,  up to a maximum of
      $3,000 per participant per plan year.  Employee  contributions  are at all
      times 100%  vested.  The  Company's  contributions  vest based on years of
      service:  0% for less than one year;  25% for one but less than two years;
      50% for two but less than three  years;  and 100% for three or more years.
      Federal  tax  laws  impose  an  overall  limit on the  amount  that may be
      contributed by participants each year under 401(k) plans.


(4)  Mr. Brewer became  President and Chief Executive  Officer of the Company at
     an annual salary of $400,000 in September 1998.

(5)  Mr. Gryska became Vice President of Finance and Chief Financial  Officer of
     the Company at an annual salary of $195,000 in December 1998.
</FN>
</TABLE>

                        Stock Option Grants and Exercises

     In the  Company's  efforts  to  recruit  the  best  available  talent  in a
competitive  labor market,  the Company  grants stock options to provide  equity
incentives. The Company currently grants stock options under the 1992 Equity and
Incentive Plan and the 1996 Non-Officer Stock Option Plan.

     The following table provides  certain  information on stock options granted
to the executive officers named in the Summary Compensation Table, in the fiscal
year ended December 31, 1999.  The Company did not grant any stock  appreciation
rights in the fiscal year ended December 31, 1999.


<TABLE>
<CAPTION>

                                          Option Grants in Last Fiscal Year

                                                                              Potential Realizable Value at
                                                                              Assumed Annual Rates of Stock
                        Individual Grants                                     Price Appreciation for Option Term(1)
                        -----------------                                     -------------------------------------


                No. of              % of Total
                Securities          Options          Exercise
                Underlying          Granted to       or Base
                Options             Employees in     Price       Expiration
Name            Granted(2)(#)       Fiscal Year      ($/Sh)(2)   Date             0%($)        5%($)         10%($)
- ----            -------------       -----------      ---------   --------         -----        -----         ------
<S>               <C>                 <C>            <C>        <C>               <C>         <C>            <C>


R. Brewer          200,000(3)          9.83           $4.09      05/02/09           0          $514,907       $1,304,877
E. Grossbard        40,000(4)          1.97           $8.75      02/08/09           0          $220,113       $  557,810
D. Gryska              -0-              --               --          --            --              --              --
J. Lewicki          20,000(4)          0.98           $8.75      02/08/09           0          $110,057       $  278,905
J. Newman           20,000(4)          0.98           $8.75      02/08/09           0          $110,057       $  278,905


<FN>
- ---------
(1)  The potential realizable value is based on the assumption that the price of
     the Common Stock appreciates at the annual rate shown, compounded annually,
     from the date of grant  until  the end of the  ten-year  option  term.  The
     numbers are calculated based on requirements  promulgated by the Securities
     and Exchange  Commission,  which did not reflect the Company's  estimate of
     future stock price growth.

(2)  See  "management   development  and  compensation   committee  report"  for
     additional  information  on these stock  options.  All grants in this table
     were made  pursuant  to the 1992  Equity  Incentive  Plan.  All options are
     granted at fair market value on the date of grant.

<PAGE>

(3)  These options vest in 4 annual  installments  commencing on May 3, 1999 and
     ending on May 3, 2002.


(4)  75% of these options vest in monthly installments  commencing on January 1,
     1999 and ending on  December  31,  2001;  25% vest in monthly  installments
     commencing January 1, 2002 and ending on December 31, 2002.

</FN>
</TABLE>


     The following table sets forth certain  information with respect to options
exercised and options held at December 31, 1999 by the executive  officers named
on the Summary Compensation Table.

<TABLE>
<CAPTION>

                 Aggregated Option Exercises in Last Fiscal Year
                            and Fy-End Option Values

                                                                                               Value of Unexercised,
                       Shares                      Number of Securities Underlying              In-the-Money Options
                    Acquired on        Value        Unexercised Options at FY-End                    at FY-End

Name                Exercise(#)       Realized($) Exercisable(#)  Unexercisable(#)     Exercisable(1)($) Unexercisable(1)($)
- ----                -----------       ----------  --------------  ----------------     ----------------- ------------------
<S>                   <C>            <C>          <C>              <C>                 <C>                  <C>



R. Brewer                0               0         180,000          295,000             $4,687.50            $14,062.50

E. Grossbard           1,500          $7,031.25    277,750           76,625                0.00                 0.00

D. Gryska                0               0          25,000           75,000                0.00                 0.00

J. Lewicki               0               0         200,000           57,250                0.00                 0.00

J. Newman                0               0         173,250           54,125                0.00                 0.00

<FN>
- ---------

(1)  Based on the  amount,  if any, by which the market  value of the  Company's
     Common Stock at December 31, 1999  ($4.1875)  exceeds the exercise price of
     the options.
</FN>
</TABLE>

                       EMPLOYMENT AND SEVERANCE AGREEMENTS

     See  "Management  Development  and  Compensation  Committee  Report - Chief
Executive  Officer  Compensation"  for a description of Mr. Brewer's  employment
agreement.


     In January  2000,  the Company  entered  into  individual  agreements  (the
"Agreements")  with Mr. Brewer and each of the Company's  other officers  (other
than Dr. Grossbard who elected not to participate).  The Agreements are intended
to encourage the Company's  officers to remain with the Company  during a period
of  uncertainty  with  respect  to  the  Company's  governance  created  by  the
nominations by the Kirk Group.

     The Agreements  provide various severance  benefits to such officers in the
event their  employment  is terminated  involuntarily  (other than for cause (as
defined in the Agreements),  disability or death) or voluntarily for Good Reason
(defined  below),  in either  case  within  one year  after a Change of  Control
(defined  below).  In general,  a Change of Control will occur if on or prior to
December 31, 2001,  (i) any person  acquires  fifty percent (50%) or more of the
voting power of the Company's  stock,  (ii) any person  acquires  twenty percent
(20%) or more of the voting  power of the  Company's  stock  unless  approved in
advance by the Board, (iii) the individuals who comprised the Company's Board of
Directors on January 11, 2000 cease to comprise a majority of the Board,  (iv) a
merger, consolidation, reorganization or sale of all or substantially all of the
Company's assets occurs and the Company's stockholders do not own at least fifty
percent (50%) of the voting securities of the entity resulting from such merger,
consolidation or reorganization or which acquires such assets, or (v) there is a
complete liquidation of the Company. The Agreements will automatically expire if
a Change of Control has not occurred by December 31,  2001,  unless  extended by
the Board for up to two  additional  years.  In general,  Good Reason  means (a)
relocation  of the  Company's  executive  offices  by more  than 40  miles,  (b)
assignment of duties  inconsistent  with the officer's  position or  substantial
adverse alteration in the officer's responsibilities from those in effect before
the Change of Control,  or (c)  reduction  in the  officer's  total  annual cash
salary and bonus opportunity.

<PAGE>

     The  Agreements  provide  for  the  following  severance  benefits  to each
officer:  (i) a lump sum payment  based on a multiple  of his or her  annualized
cash compensation,  including target bonus, (ii) continuation of the health care
benefits that were being  provided by the Company to such officer and his or her
family immediately prior to termination,  and (iii) outplacement services at the
Company's  expense  (up to a maximum  of  $10,000).  Each of the  Agreements  is
substantially identical, except that the severance compensation multiple for Mr.
Brewer  is 2.25  and  the  multiple  for  the  other  officers  is 1.5,  and the
continuation  of health  care  benefits is for  twenty-four  (24) months for Mr.
Brewer and eighteen (18) months for the other officers. In addition,  consistent
with Mr.  Brewer's  Employment  Agreement,  his  Agreement  includes  within the
meaning of Good Reason a material  change in the  principal  line of business of
the Company  without his  concurrence,  while the other  Agreements  do not. All
benefits  payable under the Agreements  would be reduced to the extent necessary
to preserve the ability of the Company to deduct the severance benefits paid and
to prevent  payments to any officer from  exceeding the limit of Section 4999 of
the Code applicable to "excess parachute payment" (as defined in Section 280G of
the Code).  The Agreements  are not employment  contracts and the Agreement with
Mr. Brewer is intended to supplement his Employment  Agreement only with respect
to severance  payments in the event of  termination  of  employment  following a
Change of Control (as described  above) and  otherwise  does not amend or modify
his Employment Agreement.

     Severance  arrangements  also are in effect for all other regular employees
of the Company,  conditional on involuntary termination or voluntary termination
upon  reductions in the  compensation  for such employees  following a Change of
Control, with the amount of severance benefits based on an employee's level with
the Company.


<PAGE>

           MANAGEMENT DEVELOPMENT AND COMPENSATION COMMITTEE REPORT(1)

     The  Management  Development  and  Compensation  Committee  of the Board of
Directors  (the  "Committee")  is  responsible  for  establishing  the Company's
compensation  programs for all employees,  including  executives.  For executive
officers,   the  Committee   evaluates   performance  and  determines   specific
compensation  policies and levels.  In 1999,  the  Committee was composed of Mr.
Armacost,  Mr. Du Bain,  Dr.  Rice,  Dr.  Sanders  and Mr.  Step.  None of these
directors were officers or employees of the Company.

Compensation Philosophy

         The goals of the  compensation  program are to link  compensation  with
business  objectives  and  performance,  and to enable the  Company to  attract,
retain and reward  executive  officers and other key employees who contribute to
the long-term success of the Company and to build long-term  stockholder  value.
Key elements of this philosophy are:

o    The  Company  pays  competitively  with  leading  biotechnology  and  other
     companies  with which the  Company  competes  for  management  or  employee
     talent. To ensure that pay is competitive,  the Company regularly  compares
     its pay practices with these companies and sets its compensation parameters
     based on this review.

o    The Company maintains annual incentive opportunities  sufficient to provide
     motivation to achieve specific  business goals and to generate rewards that
     bring total compensation to competitive levels.

o    The Company provides significant equity-based incentives for executives and
     other key employees to ensure that they are motivated over the long-term to
     respond to the Company's business challenges and strategic opportunities as
     owners as well as employees.

     The primary  components of executive  compensation are base salary,  annual
incentives  and  long-term  equity  incentives.  Over the last five  years,  the
Committee  has not  granted a salary  increase  to the CEO and has only  granted
modest or no salary  increases  over the last three  years to other  executives.
These actions reflect the Committee's intent to lower the relative percentage of
fixed compensation and increase the relative  percentage of pay at risk based on
performance.


     The Committee's  objective in general is to set each component of executive
compensation  at the market average when compared to a nationwide  survey of the
biotechnology  industry (the "comparator  group"). In 1999, the comparator group
contained  approximately 300 companies.  Many of the companies in the comparator
group are included in the indices used in the Performance Graph included in this
Proxy Statement.


     Base Salary. The Committee  annually reviews each executive  officer's base
salary against the base salaries paid for similar  positions by companies within
the comparator group. A range of salary levels is established by this comparison
targeted at the survey weighted average salary for comparable positions.  Within
this range, the Committee subjectively  considers individual factors,  including
individual performance, level of responsibility, prior experience and breadth of
knowledge,  as well as  competitive  pay  Practices  and the extent to which the
company  achieved  its  corporate  objectives  described  in the  section  below
entitled  Annual  Incentive.  From year to year,  the relative  weighting of the
individual  components and the corporate  performance  component may differ from
officer to  officer,  and can be expected to change over time in response to the
Company's evolution.


     Annual Incentive. The Employee Incentive Plan, an annual award plan, offers
variable pay for officers and other employees of the Company based on the extent
to which Company and  individual  performance  objectives  are achieved.  At the
start of each year,  the  Committee  and the full Board of Directors  review and
approve  the  annual  performance

- --------

(1)  The  material  in this  report and the chart on page 13 is not  "Soliciting
     Material",  is not deemed  "filed"  under the  Securities  Act of 1933,  as
     amended,  or the  Securities  Exchange  Act of  1934,  as  amended,  or the
     Exchange Act and is not to be  incorporated by reference into any filing of
     the Company whether made before or after the date hereof, regardless of any
     general incorporation language in such filing.

<PAGE>

objectives  for the  Company and  individual  officers.  The Company  objectives
consist of operating,  strategic and financial  goals that are  considered to be
critical to the Company's long-term goal of building stockholder value.

     After the end of the year, the Committee  evaluates the degree to which the
Company  has  met  its  objectives  and,  at the  discretion  of the  Committee,
establishes  a total  incentive  award pool under the Employee  Incentive  Plan.
Individual awards are determined by evaluating the Company's overall performance
and by evaluating  each  participant's  performance  against  objectives for the
year.  The  incentive  award pool is then  allocated  based on that  assessment.
Awards are paid in cash and  distributions  are made in February  following  the
performance year.


     The annual performance objectives established for 1999 included:

o    completing  development  benchmarks  for  the  Company's  lead  products  -
     NATRECOR(R)(nesiritide)   and   p38-kinase   inhibitors  -  that  had  been
     identified for accomplishment in 1999;

o    implementing  the Company's  1999  restructuring  plan,  including  sale of
     certain real estate, a staff reduction and other organizational  goals, and
     consolidation of facilities;

o    identifying and developing  additional products from the Company's research
     pipeline as candidates for clinical testing; and

o    financial  goals for top line revenues,  operating  expenses,  and year end
     cash position.

     In  January  2000,  the  Committee   determined   that  despite  the  FDA's
nonapproval of Natrecor(R) the Company made important progress in 1999, and that
many  of  its  corporate  objectives  were  met.  Specifically,   the  Committee
determined  that Company had  accomplished  some but not all of its  development
benchmarks for its products;  successfully  implemented its restructuring  plan,
including effecting a 30% staff reduction,  the sale of the Mountain View campus
and Baltimore building,  closing the Company's protein manufacturing facility on
schedule  after  making  sufficient  quantities  of FGF to  fulfill  contractual
obligations to Kaken,  and successful  consolidation of operations in facilities
in Sunnyvale,  following a significant construction project to expand laboratory
facilities; demonstrated efficacy in animal models of compounds being considered
as  product  candidates;   and  achieved  most  of  its  financial   objectives,
particularly  management to budget and a year-end cash position  exceeding  $100
million.  The Company was not  successful  in obtaining the approval of Natrecor
but the Committee  noted that  following the FDA's  decision,  the Company moved
quickly to design and initiate a new clinical  trial  addressing  the  questions
raised by the FDA and to create a highly qualified steering committee to oversee
the trial with the  Company.  The  Committee  also noted  that the  Company  had
secured  Chiron  Corporation  as a  partner  for FGF under  favorable  terms and
conducted two major studies further  assessing the Natrecor  market  opportunity
and the best strategy to commercialize Natrecor. The Committee took into account
that in 1999,  the  Psychiatric  Sales and  Marketing  Division  made a net cash
contribution  to the  Company  of more  than $10  million,  its  largest  annual
contribution ever. Based on the Company's performance,  the Committee determined
that a modest  incentive pool under the Employee  Incentive Plan was appropriate
and then  determined the cash incentive  award for each of the executives on the
Company's corporate management committee reflecting  individual 1999 performance
against objectives.


     Long-Term Incentives. The Company's long-term incentive program for
officers  consists of the 1983  Incentive  Stock Option Plan,  (expired March 5,
1993),  the 1986  Supplemental  Stock Option Plan (expired January 16, 1996) and
the 1992 Equity  Incentive  Plan. The option program  utilizes  vesting  periods
(generally  four years) to encourage  key employees to continue in the employ of
the Company  and to look to achieve the  Company's  long-term  strategic  goals.
Through option grants, executives receive significant equity incentives to build
long-term  stockholder  value.   Annually,  the  Committee  reviews  the  equity
incentives  of  executive  officers  and has made  additional  grants  to remain
competitive  with  the  comparator  group  and  maintain  appropriate  long-term
incentives  for key  individuals.  All grants have been made at or above 100% of
fair  market  value on the date of grant.  Executives  receive  value from these
grants only if the Company's Common Stock  appreciates  over the long-term.  The
size of option grants generally is determined based on competitive  practices at
companies in the comparator group and the Company's  philosophy of significantly
linking executive  compensation  with stockholder  interests.  In addition,  the
Committee  considers  the terms and  number of  options  previously  awarded  in
determining  the size of option grants.  The Committee  believes the approach of
making  grants that vest over an extended  time  period  creates an  appropriate
focus on longer-term objectives and promotes executive retention.

<PAGE>

     Section  162(m) of the Internal  Revenue Code limits the federal income tax
deductibility of compensation paid to the Company's CEO and to each of the other
four most highly compensated  executive  officers.  The Company intends that the
long-term incentive  compensation paid to these executives will be deductible by
the Company under Section 162(m).  In 1998, the Board and stockholders  approved
amendments to the 1992 Equity  Incentive Plan intended to meet the  requirements
of Section 162(m).

Chief Executive Officer Compensation

     Richard  B.  Brewer  became the  Company's  President  and Chief  Executive
Officer  in  September  1998.  Pursuant  to his  employment  agreement  with the
Company,  Mr. Brewer's base salary is $400,000 per annum, subject to increase by
the Board.  Mr. Brewer is also eligible to receive a cash bonus,  at the Board's
discretion,  which bonus will equal 50% of his base  salary if he meets  defined
performance  criteria  and up to a  maximum  of 100% of his base  salary  if his
performance   substantially  exceeds  the  targeted  level;  provided  that  the
guaranteed  minimum level of Mr. Brewer's bonus is $50,000 in 1998,  $200,000 in
1999 and $100,000 in 2000.  Mr. Brewer also received the stock option grants and
restricted stock grant described under "Executive  Compensation." The employment
agreement also provides that if Mr. Brewer's  employment is terminated  "without
cause" or "for good reason" (as defined in the  agreement),  he will receive his
salary for twelve months from termination, an annual bonus for such period equal
to the lesser of his  previous  year's  bonus or his  guaranteed  bonus,  and an
additional two years of vesting on his stock options and restricted  stock. Upon
a "change of control" of the Company (as defined in the agreement),  the vesting
of all of Mr. Brewer's  outstanding  stock options,  restricted shares and share
units will be accelerated.  The Committee believes Mr. Brewer's  compensation is
consistent with the special demands of the position,  the  compensation of chief
executive  officers in the comparator  group and in accord with the compensation
philosophy articulated above. See "Compensation Philosophy-Annual Incentive" and
"Compensation Philosophy-Long-Term Incentive" above.

Conclusion

     In summary, the Compensation Committee believes that, through the plans and
actions  described  above, a significant  portion of the Company's  compensation
program and, in particular, the program for executive officers, is contingent on
Company  performance,  and that the realization of benefits is closely linked to
achievement of key corporate objectives that will produce increases in long-term
stockholder  value. The Company remains  committed to this philosophy of pay for
performance,  recognizing that the Company is still in a developmental stage and
that the  competitive  market for talented  executives and the volatility of the
Company's business may result in highly variable compensation for any particular
time  period.  We  will  continue  to  monitor  closely  the  effectiveness  and
appropriateness  of each of the components of compensation to reflect changes in
the Company's business environment.

                              MANAGEMENT DEVELOPMENT AND
                              COMPENSATION COMMITTEE


                              Samuel H. Armacost, Chairman
                              Myron Du Bain
                              Donald B. Rice, Ph.D.
                              Charles A. Sanders, M.D.
                              Eugene L. Step


<PAGE>

                                PERFORMANCE GRAPH


         The rules of the  Securities and Exchange  Commission  require that the
Company  include in this Proxy  Statement a  line-graph  presentation  comparing
five-year  stockholder  returns on an indexed basis.  The Company has elected to
use the Russell 2000 Index and the Amex  Biotechnology  Index for the purpose of
the performance  comparison that appears below. The graph assumes the investment
of $100 in the  Company's  Common  Stock,  the  Russell  2000 Index and the Amex
Biotechnology  Index on December 30, 1994. The stock price  performance shown on
the graph below is not necessarily indicative of future price performance.


<TABLE>
<CAPTION>

                 Comparison of Five Year Cumulative Total Return
                    Among Scios Inc., Russell 2000 Index and
                            Amex Biotechnology Index


                   Date              Amex Biotech            Russell                  Scios
             <S>                        <C>                <C>                    <C>
              31-Dec-99                  477.0169           201.6097                63.2076
              30-Nov-99                  351.0725           181.3709                57.5472
              29-Oct-99                  320.1926           171.2095                59.4340
              30-Sep-99                  307.9942           170.6743                55.6604
              31-Aug-99                  327.5652           170.8860                55.6604
              30-Jul-99                  305.2523           177.6522                60.3774
              30-Jun-99                  261.1992           182.8048                49.0566
              28-May-99                  245.0647           175.2197                54.7170
              30-Apr-99                  232.9150           172.8751                58.4906
              31-Mar-99                  227.8211           158.8233               136.7925
              26-Feb-99                  215.4643           156.6784               139.6227
              29-Jan-99                  239.4224           170.6423               149.0566
              31-Dec-98                  225.6032           168.5413               156.6038
              30-Nov-98                  199.4029           158.8713               114.1510
              30-Oct-98                  199.9757           151.0465                79.2453
              30-Sep-98                  169.8635           145.2269                85.8491
              31-Aug-98                  127.3580           134.9857                71.6981
              31-Jul-98                  168.1453           167.6586               115.0944
              30-Jun-98                  178.9422           182.6930               133.9623
              29-May-98                  196.5269           182.3854               141.5095
              30-Apr-98                  213.4536           192.8783               177.3586
              31-Mar-98                  212.7224           191.9956               183.9623
              27-Feb-98                  195.8323           184.4664               150.9435
              30-Jan-98                  191.8596           171.7727               143.3963
              31-Dec-97                  197.9283           174.5567               150.9435
              28-Nov-97                  201.6451           171.7207               114.1510
              31-Oct-97                  206.3246           173.0548               123.5850
              30-Sep-97                  215.1231           181.2670               147.1700
              29-Aug-97                  185.6690           169.1285               113.2076
              31-Jul-97                  168.2062           165.5536               120.7548
              30-May-97                  181.3551           152.0850                95.2830
              30-Apr-97                  159.9927           137.0027                70.7547
              31-Mar-97                  170.0463           136.8270               102.8302
              28-Feb-97                  199.5491           143.8129               108.4906
              31-Jan-97                  202.4494           147.5676                89.6227
              31-Dec-96                  175.8469           144.8355                92.6887
              29-Nov-96                  164.3432           141.4404                86.7925
              31-Oct-96                  161.5282           136.0322                86.7925
<PAGE>

              30-Sep-96                  170.6312           138.3568                93.3963
              30-Aug-96                  156.7268           133.3600                86.7925
              31-Jul-96                  141.5793           126.2183                84.9057
              28-Jun-96                  171.4355           138.4487               100.0000
              31-May-96                  189.6783           144.5319               110.3774
              30-Apr-96                  182.3422           139.1117                71.6981
              29-Mar-96                  164.3066           132.1178                68.8679
              29-Feb-96                  168.6936           129.7851                74.5283
              31-Jan-96                  175.8469           125.9706                81.1321
              29-Dec-95                  163.0148           126.2063                65.0944
              30-Nov-95                  132.7443           123.2545                58.4906
              31-Oct-95                  127.7358           118.3296                54.7170
              29-Sep-95                  139.1543           123.9735                62.2642
              31-Aug-95                  134.7307           121.9484                62.2642
              31-Jul-95                  118.9496           119.7156                64.1510
              30-Jun-95                  109.6027           113.2889                61.3208
              31-May-95                   94.7599           107.9446                53.7736
              28-Apr-95                   97.6846           106.3149               101.8868
              31-Mar-95                   94.5162           104.1580               115.0944
              28-Feb-95                  101.0968           102.4804               124.5283
              31-Jan-95                   98.5864            98.5980               116.9811
              30-Dec-94                  100.0000           100.0000               100.0000
</TABLE>


<PAGE>

                     CERTAIN RELATIONSHIPS AND TRANSACTIONS

     In 1993, the Company formed Guilford Pharmaceuticals Inc. ("Guilford"). Dr.
Snyder is a director  of  Guilford.  Until  March 9,  1999,  the  Company  owned
approximately  7% of the  outstanding  stock of  Guilford.  In March  1999,  the
Company  sold  substantially  all of its  holdings  in  Guilford,  reducing  its
ownership to less than 1% of Guilford's outstanding stock.


     In 1998,  in connection  with the exercise of a stock  option,  the Company
extended a loan to Mr. Newman in the amount of $137,500. The loan bears interest
at the rate of 5.59% per annum and is  repayable  over four  years.  The current
principal balance is $98,020. Interest has been paid through March 3, 1999.



                                   PROPOSAL 2
                      RATIFICATION OF INDEPENDENT AUDITORS

     Upon  recommendation of the Audit Committee,  the Board of Directors of the
Company  appointed  PricewaterhouseCoopers  LLP to be the Company's  independent
auditors for the fiscal year ending December 31, 2000.

     Services    provided   to   the   Company   and   its    subsidiaries    by
PricewaterhouseCoopers  with respect to the fiscal year ended  December 31, 1999
included examination of the Company's consolidated financial statements, limited
reviews of  quarterly  reports,  services  related to filings  with the SEC, and
consultations concerning information systems and various tax matters.

     PricewaterhouseCoopers  has  audited  the  Company's  financial  statements
annually   since  the   Company's   inception   in  1982.   Representatives   of
PricewaterhouseCoopers are expected to be present at the Annual Meeting. They do
not  expect  to make a  statement,  but  will  have  the  opportunity  to make a
statement  if  they  desire  to do so  and  will  be  available  to  respond  to
appropriate questions.

     Stockholder ratification of the selection of  PricewaterhouseCoopers as the
Company's  independent  auditors  is not  required  by the  Company's  Bylaws or
otherwise.    However,    the   Board   is    submitting    the   selection   of
PricewaterhouseCoopers  to the stockholders for ratification as a matter of good
corporate practice. If the stockholders fail to ratify this selection, the Board
will  reconsider  whether or not to retain that firm.  Even if the  selection is
ratified,  the Board in its discretion may direct the appointment of a different
independent  accounting firm at any time during the year if the Board feels that
such  a  change  would  be  in  the  best  interests  of  the  Company  and  its
stockholders.

     Ratification  of the selection of  PricewaterhouseCoopers  as the Company's
independent  auditors for fiscal year 2000 will require the affirmative  vote of
at least a majority of the shares of Common  Stock  represented  in person or by
proxy and entitled to vote at the Annual Meeting.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL 2.


                                  OTHER MATTERS

     The Board of Directors  does not know of other matters that may come before
the  meeting.  However,  if any other  matters  are  properly  presented  to the
meeting,  it is the intention of the persons named in the accompanying  proxy to
vote, or otherwise to act, in accordance with their judgment on such matters.

<PAGE>

                  SHAREHOLDER PROPOSALS FOR 2001 ANNUAL MEETING


     Under the applicable  rules of the Securities  and Exchange  Commission,  a
stockholder  who  wishes to  submit a  director  nomination  or a  proposal  for
inclusion  in the proxy  statement  of the  Board of  Directors  for the  annual
meeting  of  stockholders  to be held in the  spring  of 2001 must  submit  such
proposal in writing to the Secretary of the Company at the  Company's  principal
executive  offices no later than  [____________],  2000. The applicable rules of
the SEC impose  certain  limitations  on the content of the  proposals  and also
contain certain  eligibility and other  requirements  (including the requirement
that the proponent must have  continuously  held at least $2,000 in market value
or 1% of the Company's Common Stock for at least one year before the proposal is
submitted).


                              By Order of the Board of Directors

                              JOHN H. NEWMAN
                              Secretary


January [___], 2000


THE BOARD OF DIRECTORS HOPE THAT STOCKHOLDERS WILL ATTEND THIS MEETING.  WHETHER
OR NOT YOU PLAN TO  ATTEND,  YOU ARE  URGED TO  COMPLETE,  SIGN AND  RETURN  THE
ENCLOSED GOLD PROXY IN THE ACCOMPANYING  ENVELOPE.  THE BOARD OF DIRECTORS URGES
YOU NOT TO SIGN ANY WHITE PROXY SENT TO YOU BY THE KIRK GROUP.  STOCKHOLDERS WHO
ATTEND THE MEETING MAY VOTE THEIR SHARES  PERSONALLY  EVEN THOUGH THEY HAVE SENT
IN THEIR PROXIES.  PLEASE NOTE, HOWEVER,  THAT IF YOUR SHARES ARE HELD OF RECORD
BY A BROKER, BANK OR OTHER NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST
OBTAIN FROM THE RECORD HOLDER A PROXY ISSUED IN YOUR NAME.


<PAGE>


                                   APPENDIX A

    INFORMATION CONCERNING DIRECTORS, EXECUTIVES AND EMPLOYEES OF THE COMPANY
             WHO MAY SOLICIT PROXIES FROM THE COMPANY'S STOCKHOLDERS

Set forth below are the present  principal  occupation  or  employment,  and the
name, principal business and address of any corporation or organization in which
such  employment is carried on, for (1) each of the Company's  directors and (2)
executives  and  employees  of the  Company  who may  solicit  proxies  from the
Company's  stockholders.  Except as otherwise  provided in this Proxy  Statement
(including  the Appendices  hereto),  none of the  individuals  listed below (i)
directly or indirectly  owns any shares of Common Stock or any other  securities
of the Company,  (ii) is, or was within the past year, a party to any contracts,
arrangements or understandings with any person with respect to any securities of
the  Company,  including  but not  limited  to joint  ventures,  loan or  option
arrangements,  puts or calls,  guarantees  against loss or guarantees of profit,
division of losses or profits, or the giving or withholding of proxies, or (iii)
to the  knowledge of the Company,  has,  directly or through an  associate,  any
arrangement or understanding  with any person with respect to future  employment
by the Company or its affiliates or with respect to any future  transactions  to
which  the  Company  or any of its  affiliates  will or may be a party,  nor any
material  interest,  direct or indirect,  in any transaction  which has occurred
since  January  1,  1999 or any  currently  proposed  transaction,  or series of
similar transactions, to which the Company or any of its affiliates was or is to
be a party and in which the amount involved exceeds $60,000.

<TABLE>
<CAPTION>

               DIRECTORS, EXECUTIVES AND EMPLOYEES OF THE COMPANY

NAME AND PRINCIPAL                             PRESENT OFFICE OR OTHER
BUSINESS ADDRESS(1)                            PRINICIPAL OCCUPATION OR
                                               OTHER EMPLOYMENT
<S>                                           <C>


Donald B. Rice, Ph.D.                          Chairman of the Board President and Chief Executive Officer of
UroGenesys, Inc.                               UroGenesys, Inc.
1701 Colorado Avenue
Santa Monica, CA  90404-3436


Richard B. Brewer                              President and Chief Executive Officer

Samuel H. Armacost                             Chairman, SRI International
SRI International
333 Ravenswood Avenue
Menlo Park, CA  94025

Myron Du Bain                                  Chairman and Chief Executive Officer (Retired),
Bay Isle Financial Corporation                 Firemen's Fund Corporation
160 Sansome, 17th floor
San Francisco, CA  94014

Charles A. Sanders, M.D.                       Chairman and Chief Executive Officer (Retired), Glaxo, Inc.
Europa Center
100 Europa Drive, Suite 170
Chapel Hill, NC  27514

<PAGE>

Solomon H. Snyder, M.D.                        Director, Department of Neuroscience,
The John Hopkins University                    Distinguished Service Professor of Neuroscience, Pharmacology and
School of Medicine                             Molecular Sciences and Psychiatry, The John Hopkins University
Department of Neuroscience
725 No. Wolfe Street
Baltimore, MD  21205

Burton E. Sobel, M.D.                          E.L. Amidon Professor and Chair, Department of Medicine,
The University of Vermont                      The University of Vermont
College of Medicine

Fletcher House/MCHV
111 Colchester Avenue
Burlington, VT  05401

Eugene L. Step                                 Executive Vice President, President of the Pharmaceutical Division
P.O. Box 8997                                  (Retired), Eli Lilly Company
Rancho Santa Fe, CA  92067


Lauretta C. Cesario                            Vice President of Human Resources

Jack Cohen, Ph.D.                              Vice President of Quality


Thomas L. Feldman                              Vice President of Sales and Marketing

Elliott B. Grossbard, M.D.                     Senior Vice President of Development

David W. Gryska                                Vice President of Finance and Chief Financial Officer

John A. Lewicki, Ph.D.                         Vice President of Research

John H. Newman                                 Senior Vice President, General Counsel & Secretary

George F. Schreiner, M.D., Ph.D.               Vice President, Cardiorenal Research

Wendy Carhart                                  Senior Manager of Investor Relations

<FN>
(1)  The principal  business  address of each executive  officer and employee of
     the Company is 820 West Maude Avenue, Sunnyvale, California 94086.
</FN>
</TABLE>

<PAGE>

                                   APPENDIX B

SHARES OF COMMON STOCK HELD BY THE COMPANY'S DIRECTORS, EXECUTIVES AND EMPLOYEES
 WHO MAY SOLICIT PROXIES, AND CERTAIN TRANSACTIONS BETWEEN ANY OF THEM AND THE
                                    COMPANY

     Dr. Rice beneficially owns 66,250 shares of Company Common Stock (including
46,250 shares  subject to stock options  exercisable  within 60 days of December
31, 1999).

     Mr.  Brewer  beneficially  owns  285,000  shares of  Company  Common  Stock
(including 180,000 shares subject to stock options exercisable within 60 days of
December 31, 1999).

     Mr.  Armacost  beneficially  owns  60,500  shares of Company  Common  Stock
(including 35,500 shares subject to stock options  exercisable within 60 days of
December 31, 1999).

     Mr. Du Bain  beneficially  owns  63,500  shares  of  Company  Common  Stock
(including 33,500 shares subject to stock options  exercisable within 60 days of
December  31, 1999 and 25,000  shares held in a revocable  living  trust for the
benefit of Mr. Du Bain and his wife; Mr. Du Bain is a trustee of such trust).

     Dr. Sanders beneficially owns 27,166 shares of Company Common Stock (all of
which are subject to stock  options  exercisable  within 60 days of December 31,
1999).

     Dr.  Snyder  beneficially  owns  42,333  shares  of  Company  Common  Stock
(including 22,333 shares subject to stock options  exercisable within 60 days of
December 31, 1999).  In 1993, the Company formed Guilford  Pharmaceuticals  Inc.
("Guilford").  Dr.  Snyder is a director of Guilford.  Until March 9, 1999,  the
Company owned  approximately 7% of the outstanding  stock of Guilford.  In March
1999, the Company sold  substantially all of its holdings in Guilford,  reducing
its ownership to less than 1% of Guilford's outstanding stock.

     Dr. Sobel  beneficially  owns 33,500 shares of Company Common Stock (all of
which are subject to stock  options  exercisable  within 60 days of December 31,
1999).

     Mr. Step beneficially owns 42,500 shares of Company Common Stock (including
41,500 shares  subject to stock options  exercisable  within 60 days of December
31, 1999).


     Ms. Cesario beneficially owns 23,757 shares of Company Common Stock (all of
which are subject to stock  options  exercisable  within 60 days of December 31,
1999).

     Dr.  Cohen   beneficially  owns  87,235  shares  of  Company  Common  Stock
(including 86,902 shares subject to stock options  exercisable within 60 days of
December 31, 1999).


     Mr.  Feldman  beneficially  owns  107,260  shares of Company  Common  Stock
(including 104,560 shares subject to stock options exercisable within 60 days of
December 31,  1999).  In 1995,  Mr.  Feldman  received a relocation  loan in the
amount of $275,000 to assist in his move to  California as part of the Company's
decision to bring the management offices for its commercial  operations division
to the  Company's  headquarters.  The  loan is  being  forgiven  over 5 years of
employment.  $110,000 in principal was outstanding under the loan as of December
31, 1999.

     Dr.  Grossbard  beneficially  owns 291,865  shares of Company  Common Stock
(including 284,081 shares subject to stock options exercisable within 60 days of
December 31, 1999).


     Mr.  Gryska  beneficially  owns  69,666  shares  of  Company  Common  Stock
(including 29,166 shares subject to stock options  exercisable within 60 days of
December 31, 1999).

<PAGE>

     Dr.  Lewicki  beneficially  owns  222,773  shares of Company  Common  Stock
(including 204,872 shares subject to stock options exercisable within 60 days of
December 31, 1999).


     Mr.  Newman  beneficially  owns  272,173  shares of  Company  Common  Stock
(including 178,123 shares subject to stock options exercisable within 60 days of
December 31, 1999,  7,000 shares held in Mr.  Newman's  spouse's IRA account and
2,000  shares  held for the  benefit  of Mr.  Newman's  children).  In 1998,  in
connection with the exercise of a stock option,  the Company  extended a loan to
Mr.  Newman in the amount of  $137,500.  The loan bears  interest at the rate of
5.59% per annum and is repayable over four years. The current  principal balance
is $98,020. Interest has been paid through March 3, 1999.


     Dr. Schreiner beneficially owns 69,925 shares of Company Common Stock, all
of which are subject to stock options exercisable within 60 days of December 31,
1999).  Dr.  Schreiner  received a relocation  loan in the amount of $150,000 in
connection  with his  commencement  of employment  with the Company in 1997. The
loan is being  forgiven  over 4 years of  employment.  $60,000 in principal  was
outstanding under the loan as of December 31, 1999.


     Ms. Carhart does not beneficially own any shares of Company Common Stock.


             TRANSACTIONS IN COMMON STOCK WITHIN THE PAST TWO YEARS

 Listed below are the only  purchases  and sales of Company  Common Stock within
 the past two years by the  directors,  executives  and employees of the Company
 who may  solicit  proxies on the  Company's  behalf,  and  certain  information
 concerning  such  transactions.   To  the  Company's  knowledge,  no  director,
 executive or employee who may solicit proxies on the Company's  behalf made any
 other transactions in Company securities within the past two years.

<TABLE>
<CAPTION>

Name                                          Number of Shares Purchased/                Date of Transaction
                                              (Sold)
<S>                                                          <C>                             <C>

Donald B. Rice, Ph.D.                                           2,000                         09/17/98
                                                                8,000                         10/16/98

Richard B. Brewer                                             100,000 (1)                     09/09/98
                                                                5,000                         12/20/99

Samuel H. Armacost                                                  0                            --

Myron Du Bain                                                       0                            --

Charles A. Sanders, M.D.                                            0                            --

Solomon H. Snyder, M.D.                                       10,000                          10/27/98

Burton E. Sobel, M.D.                                               0                            --

Eugene L. Step                                                      0                            --

Lauretta C. Cesario                                             3,500                         10/15/98
                                                               (1,200)                        01/04/99
                                                               (2,300)                        02/11/99

Jack Cohen                                                          0                            --

<PAGE>

Thomas L. Feldman                                                   0                            --


Elliott B. Grossbard, M.D.                                      2,000                         10/09/98
                                                                1,500 (5)                     01/07/99
                                                              (1,500) (5)                     01/07/99
                                                                1,500                         12/14/99

David W. Gryska                                                40,000 (1)                     08/09/99
                                                                  500                         12/20/99

John A. Lewicki, Ph.D.                                         20,000 (2)                     02/20/98
                                                             (20,000) (2)                     02/20/98
                                                               20,000 (2)                     02/23/98
                                                             (20,000) (2)                     02/23/98
                                                                2,000                         12/21/99

John H. Newman                                                20,000  (3)(4)                  03/03/98
                                                                5,000    (2)                  03/06/98
                                                              (5,000)    (2)                  03/06/98
                                                                5,000    (2)                  03/09/98
                                                              (5,000)    (2)                  03/09/98
                                                                5,000 (3)(4)                  03/10/98
                                                                5,000    (2)                  03/10/98
                                                              (5,000)    (2)                  03/10/98
                                                                5,000                         09/16/98
                                                                2,000                         10/08/98

George F. Schreiner, M.D., Ph.D.                                    0                            --

Wendy Carhart                                                       0                            --

<FN>

(1)  Shares  purchased  in the form of a  Restricted  Stock  Award.

(2)  Shares  purchased  through  exercise of stock  options and sold in the same
     day.

(3)  Shares purchased through exercise of stock options.

(4)  The  Company  extended a loan to Mr.  Newman for a portion of the  purchase
     price of these  shares.  The loan is  described  above  under Mr.  Newman's
     beneficial  ownership.

(5)  Shares purchased through exercise of stock options and given to a charity.

</FN>
</TABLE>


<PAGE>



 SCIOS INC. PROXY SOLICITED BY THE BOARD OF DIRECTORS FOR THE ANNUAL MEETING OF
                   STOCKHOLDERS TO BE HELD FEBRUARY 28, 2000


SCIOS INC. ANNUAL MEETING TO BE HELD ON FEBRUARY 28, 2000 AT 9:00 a.m.


PLEASE MARK  / X /  VOTES AS IN THIS EXAMPLE

THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR PROPOSALS 1 AND 2.

1.       Election of Directors.

NOMINEES: 01- Samuel H. Armacost, 02- Richard B. Brewer, 03 -Donald B. Rice, 04-
Charles A. Sanders,  05- Solomon H. Snyder,  06- Burton E. Sobel,  07- Eugene L.
Step,

FOR ALL NOMINEES         /    /
WITHHOLD ALL NOMINEES    /    /
For all nominees except as noted below

Use Number(s) Only__________________________________

2. To  ratify  the  selection  of  PricewaterhouseCoopers  LLP as the  Company's
Independent auditors for fiscal 2000.

FOR      /    /   AGAINST  /    /   ABSTAIN /    /

MARK HERE IF YOU PLAN TO ATTEND THE MEETING  /   /
MARK HERE FOR ADDRESS CHANGE AND NOTE BELOW  /   /

(Please sign  exactly as name  appears.  When shares are held by joint  tenants,
both should sign. When signing as attorney, as executor, administrator,  trustee
or guardian,  please give full title as such. If a  corporation,  please sign in
full corporate name by President or other authorized  officer. If a partnership,
please sign in partnership name by authorized person.)

Signature:_______________________________________      Date:_______________

Signature:_______________________________________      Date:_______________

<PAGE>




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