SCIOS INC
PRRN14A, 2000-01-04
PHARMACEUTICAL PREPARATIONS
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                                SCHEDULE 14A
                               (RULE 14A-101)
                  INFORMATION REQUIRED IN PROXY STATEMENT
                          SCHEDULE 14A INFORMATION


              PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE
             SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. 2)


 Filed by the Registrant ( )
 Filed by a Party other than the Registrant (X)
 Check the appropriate box:
 (X) Preliminary Proxy Statement
 ( ) Confidential, for Use of the Commission Only (as permitted by Rule
      14a-6(e)(2))
 ( )  Definitive Proxy Statement
 ( )  Definitive Additional Materials
 ( )  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                                 SCIOS INC.
              -----------------------------------------------
              (Name of Registrant as Specified in Its Charter)

                               RANDAL J. KIRK
                                RJK, L.L.C.
                             KIRKFIELD, L.L.C.
         THE KIRK FAMILY INVESTMENT PLAN (Name of Person(s) Filing
         ---------------------------------------------------------
               Proxy Statement, if other than the Registrant)

 Payment of filing fee (Check the appropriate box):
 (X)  No fee required.
 ( )  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
 (1)  Title of each class of securities to which transaction applies:
      -----------------------------------------------------
 (2)  Aggregate number of securities to which transaction applies:
      -----------------------------------------------------
 (3)  Per unit price or other underlying value of transaction computed
      pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
      filing fee is calculated and state how it was determined):
      -----------------------------------------------------
 (4)  Proposed maximum aggregate value of transaction:
      ----------------------------------------------------
 (5)  Total fee paid:
      ----------------------------------------------------
 ( )  Fee paid previously with preliminary materials:
      ----------------------------------------------------
 ( )  Check box if any part of the fee is offset as provided by Exchange
      Act Rule 0-11(a)(2) and identify the filing for which the offsetting
      fee was paid previously. Identify the previous filing by registration
      statement number, or the Form or Schedule and the date of its filing.
 (1)  Amount Previously Paid:
      ----------------------------------------------------
 (2)  Form, Schedule or Registration Statement No.:
      ----------------------------------------------------
 (3)  Filing Party:
      ----------------------------------------------------
 (4)  Date Filed:
      ----------------------------------------------------




                              January 4, 1999


 Dear Fellow Stockholder:

      My name is Randal J. Kirk, and I am a stockholder of Scios Inc. with
 an investment of 2,000,000 shares, or approximately 5.2 percent of the
 Company's total shares currently outstanding.

      DURING THE PAST YEAR, UNDER THE PRESENT BOARD OF DIRECTORS AND
 MANAGEMENT, SCIOS' STOCK PRICE HAS DECLINED 68% FROM ITS HIGH OF $12.50
 PER SHARE TO $4.19 PER SHARE AS OF DECEMBER 31, 1999. This is in sharp
 contrast to the performances of many other biotechnology company shares,
 many of which reached record highs during this same time. There has been a
 86.93% decline in share price of Scios since 1992 when the share price
 reached a high of $26.13.

      Scios' Stockholders, as the Company's owners, have every right to be
 concerned about the value of their investment. According to an article in
 the May 31, 1999 issue of Forbes ASAP magazine, "Scios is the oldest
 biotech company in the world without an approved product." This is a
 notable distinction, which the Company has held for some time. As long ago
 as 1992, Alex Barnum wrote in the San Francisco Chronicle that Scios
 "holds the dubious distinction of being the oldest biotech company with no
 marketable products." It is time for a change!

      I AM SENDING YOU THE ENCLOSED WHITE PROXY CARD AND PROXY STATEMENT
 SEEKING YOUR SUPPORT TO ELECT A NEW BOARD OF DIRECTORS AT THE ANNUAL
 MEETING OF SCIOS STOCKHOLDERS ON FEBRUARY 28, 2000. The nominees for this
 new board all have as their primary commitment the enhancement of
 stockholder value and, if appropriate, consistent with this commitment,
 the replacement of some of senior management.

      YOU CAN DETERMINE THE FUTURE OF YOUR INVESTMENT IN SCIOS BY VOTING
 THE WHITE PROXY CARD TODAY FOR THE INDIVIDUALS I AM NOMINATING TO FORM THE
 NEW SCIOS BOARD OF DIRECTORS.

      We are committed to building stockholder value. Please do not send
 back any gold proxy card you will receive from Scios' incumbent board and
 management, even to vote against their nominees.

      If you have any questions as to how to vote your shares, please call
 our proxy solicitor, Corporate Investor Communications, Inc., 111 Commerce
 Drive, Carlstadt, NJ 07072, toll free at (877) 842-2404.

      Thank you for your attention.


                               Respectfully,

                               /s/ Randal J. Kirk
                               Randal J. Kirk



                                 IMPORTANT

 Your vote is important. No matter how many or how few shares of Scios you
 own, please vote FOR the Kirk Stockholders' nominees and AGAINST the
 incumbent Board by signing, dating and mailing the enclosed WHITE proxy
 card.


 Please do not send back any gold proxy card you receive from the Company.
 If you have already done so, you have every right to change your vote by
 signing and returning the enclosed WHITE proxy card. Only your latest
 dated, properly executed proxy card will count.


 If you own your shares in the name of a brokerage firm, your broker cannot
 vote such shares unless he receives your specific instructions. Please
 sign, date and return the enclosed WHITE proxy card in the postage-paid
 envelope that has been provided.

 If you have any questions as to how to vote your shares, please call our
 proxy solicitor:


                  Corporate Investor Communications, Inc.
                             111 Commerce Drive
                            Carlstadt, NJ 07072
                         Toll free: (877) 842-2404




                              PRELIMINARY COPY
============================================================================

 [The information included herein is as it is expected to be when the
 definitive proxy statement is mailed to shareholders of Scios Inc. This
 Proxy Statement will be revised to reflect actual facts at the time of the
 filing of the definitive proxy statement.]


                       ------------------------------

                             PROXY STATEMENT OF
                               RANDAL J. KIRK
                                RJK, L.L.C.
                             KIRKFIELD, L.L.C.
                      THE KIRK FAMILY INVESTMENT PLAN

                       ------------------------------

                       ANNUAL MEETING OF STOCKHOLDERS
                                     OF
                                 SCIOS INC.
                        TO BE HELD FEBRUARY 28, 2000

                       ------------------------------

 Dear Fellow Stockholder of SCIOS INC.:

      This Proxy Statement is furnished to the holders of common stock, par
 value $.001 per share (the "Common Stock"), of Scios Inc. (the "Company"),
 in connection with the solicitation by Randal J. Kirk, a citizen of the
 United States ("Mr. Kirk"), and each of the following entities that Mr.
 Kirk directly controls: RJK, L.L.C., a Virginia limited liability company
 ("RJK"), Kirkfield, L.L.C., a Virginia limited liability company
 ("Kirkfield"), and The Kirk Family Investment Plan, a joint account
 ("KFIP" and, together with Mr. Kirk, RJK and Kirkfield, the "Kirk
 Stockholders"), for use at the 2000 Annual Meeting of Stockholders of the
 Company to be held on February 28, 2000, at a time and site to be selected
 by the Company, or any adjournments or postponements thereof (the
 "Meeting").


      Proxies are being solicited to elect the following slate of Directors
 proposed by the Kirk Stockholders: John H. Greist, M.D., Larry D. Horner,
 Kurt P. Kalm, Randal J. Kirk, Domenic A. Sica, M.D., John P. Szlasa and
 William E. Yelle (collectively, the "Nominees"). The Company has set the
 record date for determining stockholders entitled to notice of and to vote
 at the Meeting as of January 11, 2000 (the "Record Date"). The Proxy
 Statements and the WHITE proxy cards are expected to be mailed by the Kirk
 Stockholders to stockholders on or about [ ]. According to the Company's
 Form 10-Q for the quarter ended September 30, 1999, as of October 12,
 1999, there were 38,468,652 shares of Common Stock outstanding. As of the
 date hereof, the Kirk Stockholders are the beneficial owners of an
 aggregate of 2,000,000 shares which represents greater than 5% of the
 shares outstanding (based on information publicly disclosed by the
 Company). See Appendix A for a detailed summary of all purchases and sales
 of shares of Common Stock by the Kirk Stockholders.

      Although the Kirk Stockholders have not yet formulated any specific
 plans for the Company, we, nonetheless, intend to do so well in advance of
 the 2000 Annual Meeting of Stockholders. Because the Meeting is typically
 held in May, the Kirk Stockholders initially anticipated a several month
 planning period. However, in light of the Company's decision to move the
 meeting from May to February, the Kirk Stockholders have restructured
 their timeline and are now in the process of formulating specific plans.
 Once formulated, the Kirk Stockholders will communicate such specific
 plans to their fellow shareholders promptly. In addition, the Kirk
 Stockholders intend to continue to have discussions with other
 stockholders of the Company in order to solicit their thoughts as to the
 future direction that should be taken by the Company and, whenever
 feasible, the Kirk Stockholders will incorporate such stockholder
 suggestions into their specific plans. Although the Kirk Stockholders can
 give no assurance that there will be an increase in profitability or
 stockholder value should their Nominees be elected to the Board of
 Directors or should any such specific plans for the Company be
 implemented, we are, nonetheless, convinced that only with a change in the
 business strategy of the Company can stockholders hope to achieve the
 necessary catalyst for increased shareholder value.


      According to the Company's most recent Form 10-Q for the quarter
 ended September 30, 1999, the Company's principal executive offices are
 located at 820 West Maude Avenue, Sunnyvale, California 94086. The
 business address for the Kirk Stockholders is c/o Third Security, LLC, The
 Governor Tyler, 1902 Downey Street, Radford, Virginia 24141.

 VOTING
 ------

      Each share of Common Stock issued and outstanding on the Record Date
 is entitled to one vote. In the election of Directors, the seven
 candidates receiving the highest number of affirmative votes of the shares
 present and voting at the Meeting at which a quorum is present will be
 elected Directors. With respect to the election of Directors, the proxy
 holder identified in the Kirk Stockholders' WHITE proxy card accompanying
 this Proxy Statement will vote all WHITE proxy cards in accordance with
 the instructions contained in the WHITE proxy card and, if no choice is
 specified, the proxy holder will vote in favor of the Kirk Stockholders'
 proposal to elect the Nominees. The presence at the Meeting in person or
 by proxy of a majority of the shares outstanding as of the Record Date
 will constitute a quorum. Abstentions and broker non-votes are counted
 towards a quorum. Abstentions are counted in tabulations of the votes cast
 on proposals presented to stockholders and have the effect of negative
 votes, whereas broker non-votes are not counted for any purpose in
 determining whether a proposal has been approved.


      Remember, your last dated proxy is the only one that counts, so
 return the Kirk Stockholders' WHITE proxy card accompanying this Proxy
 Statement even if you delivered a prior proxy to the Company. We urge you
 NOT TO VOTE any GOLD proxy card sent to you by the Company with respect to
 the Company's slate of nominees to the Board of Directors. If you have
 already done so, you have every right to change your vote by signing and
 returning the enclosed WHITE proxy card. Only your latest dated, properly
 executed proxy card will count.


 REVOCABILITY OF PROXIES
 -----------------------


      Any person giving a WHITE proxy card in the form accompanying this
 Proxy Statement has the power to revoke it at any time before its
 exercise. It may be revoked by filing with Corporate Investor
 Communications, Inc., P.O. Box 5009, South Hackensack, NJ 07606, an
 instrument of revocation or a duly executed proxy bearing a later date. It
 also may be revoked by attending the Meeting and voting in person.
 Attendance at the Meeting will not itself revoke a proxy.


 SOLICITATION
 ------------

      Copies of solicitation material will be furnished without charge to
 banks, brokerage houses, fiduciaries and custodians holding in their name
 shares of Common Stock beneficially owned by others to forward to such
 beneficial owners. The solicitation of proxies will be made by the use of
 the mails and through direct communication with certain stockholders or
 their representatives by the Kirk Stockholders and their affiliates, who
 will receive no additional compensation therefor. In addition, the Kirk
 Stockholders have decided to engage Corporate Investor Communications,
 Inc. to solicit proxies, and the Kirk Stockholders will pay the standard
 fee for these services, which is estimated to be approximately $70,000,
 plus reasonable out-of-pocket expenses and indemnification against certain
 liabilities. Approximately 15 persons will be used by Corporate Investor
 Communications, Inc. in its solicitation efforts.

      The Kirk Stockholders will bear the entire cost of their
 solicitation. Although no precise estimate can be made at the present
 time, the Kirk Stockholders currently estimate that the total expenditures
 relating to the proxy solicitation incurred by the Kirk Stockholders will
 be approximately $500,000. The aggregate amount to be spent will vary
 depending on, among other things, any developments that may occur in the
 proxy contest. No determination has been made by the Kirk Stockholders at
 this time as to whether they will seek reimbursement from the Company for
 the costs incurred in connection with the Kirk Stockholders' solicitation
 of security holders or whether the question of such reimbursement will be
 submitted to a vote of security holders.

      Please complete, date and sign the enclosed WHITE proxy card and
 return it promptly in the envelope provided. If your shares are held in
 "street name," only your bank or broker can vote your shares and only upon
 your specific instructions. Please contact the person responsible for your
 account and instruct him or her to vote the WHITE proxy card as soon as
 possible.

 NOMINEES OF THE KIRK STOCKHOLDERS FOR ELECTION OF DIRECTORS
 -----------------------------------------------------------

      According to the Company's proxy statement filed in connection with
 the Meeting, pursuant to the procedure set forth in the Company's
 Certificate of Incorporation, the number of Directors of the Company has
 been reduced from eight to seven Directors effective immediately prior to
 the election of Directors at the Meeting and accordingly, a Board of seven
 (7) Directors will be elected. The term of office of each person so
 elected as a Director will continue until the next annual meeting or until
 a successor has been elected.


      The Kirk Stockholders are proposing to elect the following seven
 Nominees to the Board of Directors to hold office until the next annual
 meeting of stockholders and until their successors have been elected and
 qualify:  John H. Greist, M.D., Larry D. Horner, Kurt P. Kalm, Randal J.
 Kirk, Domenic A. Sica, M.D., John P. Szlasa and William E. Yelle.  None of
 the Nominees are members of the present Board.  Each Nominee is a citizen
 of the United States.

      Each Nominee has consented in writing to being named as a nominee for
 election as a Director in the Kirk Stockholders' proxy material to be used
 in connection with the Meeting and, if elected, has consented to serving
 as a Director. The Kirk Stockholders are unaware of any reason why any
 Nominee, if elected, should be unable to serve as a Director. If for any
 reason any of the seven named Nominees is unable or declines to serve, the
 WHITE proxy cards solicited by the Kirk Stockholders will be voted for any
 substitute nominee who shall be designated by the Kirk Stockholders to
 fill the vacancy.

      The members of the Board of Directors are elected by a plurality of
 the shares present in person or represented by proxy at the Meeting, and
 voting on the election of Directors. Unless otherwise instructed, the Kirk
 Stockholders' proxy holder will vote the WHITE proxy cards received by him
 FOR the election of the seven Nominees to the Board of Directors named
 herein.

      Each of the Nominees has furnished the Kirk Stockholders with
 information concerning their principal occupations for the preceding
 five-year period, business addresses and other matters as of December 20,
 1999. Except as disclosed herein, according to the Nominees' executed
 questionnaires, (a) none of the Nominees has ever served as an officer,
 director or employee of the Company; (b) there are no arrangements or
 understandings between any Nominee and any other person pursuant to which
 he was selected as a Nominee to serve as a Director of the Company or with
 respect to any future employment by the Corporation or any future
 transactions to which the Company or any of its affiliates will or may be
 a party; and (c) none of the Nominees shall receive any form of
 compensation for serving in the capacity as a Director of the Company,
 other than any compensation currently paid by the Company to its Directors
 in their capacity as a Director. In addition, Mr. Kirk, one of the Kirk
 Stockholders, is also a Nominee.

 BIOGRAPHICAL INFORMATION CONCERNING THE NOMINEES
 ------------------------------------------------

      John H. Greist, M.D.  Dr. Greist, age 60, has served as Chief
 Executive Officer of Healthcare Technology Systems, LLC (HTS) since May
 1998.  Between July 1992 and April 1998, Dr. Greist served as Distinguished
 Senior Scientist, Dean Foundation for Health, Research and Education.  Dr.
 Greist also currently serves as Director of the Bipolar, Obsessive
 Compulsive ad Lithium Information Centers and as a Clinical Professor of
 Psychiatry at the University of Wisconsin Medical School.  Dr. Greist's
 address is Healthcare Technology Systems, LLC (HTS), 7617 Mineral Point
 Road, Suite 300, Madison, Wisconsin 53717.

      Larry D. Horner.  Mr. Horner, age 65, currently serves as Chairman of
 the Board of Directors of Pacific USA Holdings Corp. and of Asia Pacific
 Wire & Cable Ltd. (of which he is also the Chief Executive Officer).  In
 addition, Mr. Horner currently serves as a director on the board of
 directors of each of the following public companies:  American General
 Corp.; Laidlaw Global Corp.; Phillips Petroleum Company; Newmark Homes
 Corp.; and Atlantis Plastics.  Mr. Horner's address is Pacific USA Holdings
 Corp., 100 Park Avenue, 28th Floor, New York, New York 10017.

      Kurt P. Kalm.  Mr. Kalm, age 47, currently serves as Senior Vice
 President of Arnhold and S. Bleichroeder, Inc.  Mr. Kalm's address is
 Arnhold and S. Bleichroeder, Inc., 1345 Avenue of the Americas, New York,
 New York 10105.


      Randal J. Kirk.  Mr. Kirk, age 45, has served as the Managing Director
 of Third Security, LLC since 1999.  In addition, Mr. Kirk currently serves
 in the following capacities:  Chairman of Lotus Biochemical Corporation
 since 1996; Manager of New River Management Company, L.L.C. since 1996;
 Chairman of BCCX, Inc. since 1998; Chairman of SFR, LLC since 1998;
 Chairman of Clinical Chemistry Holdings, Inc. since 1999; Chairman of
 Biopop Integration Group, Inc. since 1999; and Manager of Zhong Mei, LLC
 since 1999.  Previously, Mr. Kirk served in the following capacities during
 the past five years:  Chairman of General Injectables & Vaccines, Inc.
 between 1994 and 1998; and Chairman and Chief Executive Officer of
 Biological & Popular Culture, Inc. between 1996 and 1998.  Mr. Kirk's
 address is Third Security, LLC, The Governor Tyler, 1902 Downey Street,
 Radford, Virginia 24141.  Mr. Kirk is one of the Kirk Stockholders who is
 nominating the Nominees.


      Domenic A. Sica, M.D.  Dr. Sica, age 50, currently serves as Professor
 of Pharmacology in the Department of Medicine at Virginia Commonwealth
 University and as Professor of Medicine at the Medical College of Virginia.
 Dr. Sica also serves as Chief of the Division of Clinical Pharmacology and
 Hypertension, as Chief of the Renal Pharmacology Section of the Division of
 Nephrology, and as the Director of the University Ambulatory and
 Hypertension Research Unit at the Medical College of Virginia.  Dr. Sica's
 address is Virginia Commonwealth University, Department of Medicine of
 Virginia Commonwealth University, Broad Street, Richmond, Virginia 23290-
 0160.

      John P. Szlasa.  Mr. Szlasa, age 63, founded and currently serves as
 President of the Conectics Group at Thomas Ferguson Associates of the WPP
 Group PLC.  Mr. Szlasa's address is Thomas Ferguson Associates, 30 Lamdex
 Plaza, Parsippany, New Jersey 07054.

      William E. Yelle.  Mr. Yelle, age 36, currently serves as Vice
 President of Business Development at Sepracor Inc.  Prior to joining
 Sepracor Inc. in 1995, Mr. Yelle held positions in business development,
 new product planning, managed care marketing and marketing research at
 Pfizer, Inc.  Mr. Yelle formerly worked in assay development at PB
 Diagnostics.  Mr. Yelle's address is Sepracor Inc., 111 Locke Drive,
 Marlboro, Massachusetts 01752.

 STOCKHOLDINGS IN THE COMPANY
 ----------------------------

      None of the Nominees beneficially own any Common Stock of the
 Company, except as follows:

           Mr. Kirk beneficially owns 2,000,000 shares of Common Stock,
      representing approximately 5.2% of the 38,468,652 shares of Common
      Stock outstanding on October 12, 1999 (as reported by the Company in
      its Form 10-Q for the quarter ended September 30, 1999), as follows:
      1,136,600 shares held by Mr. Kirk; 387,000 shares held by RJK;
      225,000 shares held by Kirkfield; and 251,400 shares held by KFIP.
      Mr. Kirk has sole voting and dispositive power with respect to the
      1,136,600 shares held by him, and RJK, Kirkfield and KFIP each share
      voting and dispositive power with Mr. Kirk with respect to their
      respective shares. See Appendix A for a detailed summary of all
      purchases and sales of shares of Common Stock by the Kirk
      Stockholders.

 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 ----------------------------------------------

      Transactions with Management and Others. Except as set forth below,
 none of the Nominees is currently involved, or has been involved since
 January 1, 1999, in any transaction, series of transactions or proposed
 transactions to which the Company or any of its subsidiaries was or is to
 be a party:

           During 1999, the Kirk Stockholders engaged in preliminary
      discussions with representatives of the Company concerning the
      possible sale to the Company of Lotus Biochemical Corporation
      ("Lotus"), a company for which Mr. Kirk acts as Chairman of the
      Board, and in which the Kirk Stockholders currently own approximately
      80.31% of the shares (the "Proposal"). The Proposal included Lotus'
      financial assets, certain commercialized products and a number of
      patent-protected products under development for the treatment of
      various thyroid-related conditions. As proposed on August 13, 1999 by
      Mr. Kirk to the Company, the Proposal would have resulted in the
      acquisition of 100% of Lotus by the Company in exchange for shares of
      Common Stock of the Company at a ratio of 510 shares of the Company's
      Common Stock in exchange for one Lotus share of common stock, which
      would have represented approximately 16.6% of the outstanding shares
      of the Company's Common Stock issued to the stockholders of Lotus
      upon completion of the Lotus acquisition.


           On September 14, 1999, Mr. Kirk withdrew the thyroid-related
      intellectual property from the Proposal and invited a share offer from
      the Company for Lotus exclusive of the thyroid-related property.  As
      more fully detailed below, after advising the Company that he did not
      wish to own more Scios stock without significant management changes
      or changes in the business strategy of the Company, Mr. Kirk formally
      withdrew his proposal on October 27, 1999.

           Initially, Mr. Kirk was encouraged by the Company's expressions
      of interest in the Proposal. However, the Company failed to follow up
      with any questions or discussions about the thyroid-related
      intellectual property. Due to the Company's inaction and its track
      record of not bringing any products to market since it was founded,
      Mr. Kirk began to seriously question the Company's interest in the
      thyroid-related intellectual property as well as its ability to
      implement such products' commercialization. Because of the value the
      thyroid-related intellectual property represented to Lotus and to Mr.
      Kirk as its largest stockholder, such concerns ultimately caused Mr.
      Kirk to withdraw the thyroid-related intellectual property from the
      Proposal.

           Shortly after the thyroid-related intellectual property was
      withdrawn, Mr. Kirk was advised by the Company that it may have an
      interest in one of Lotus' commercialized products. On October 14,
      1999, nearly a month after informing Mr. Kirk of the Company's
      possible interest in one of these commercialized products, the
      Company informed Mr. Kirk that it might consider obtaining an
      interest in the product only after a further review of available
      products from various sources, which review the Company did not
      expect to complete until the end of 1999.

           The Company's delay in responding to the Proposal and its
      failure to provide definitive answers about its interest in the Lotus
      products, both before the thyroid-related intellectual property was
      withdrawn and after, caused Mr. Kirk to seriously question the manner
      in which the board and management conducted itself in assessing
      opportunities with the potential for increasing shareholder value. As
      a result, Mr. Kirk advised the Company that he did not wish to own
      more Scios stock absent significant management changes or changes in
      the business strategy of the Company and formally withdrew his
      remaining proposal on October 27, 1999.

           Mr. Kirk has no present intention of initiating any such
      Proposal if elected as a Director. Further, any transactions between
      the Company and any Nominee or any of the Kirk Stockholders would be
      subject to applicable fiduciary standards, including approval by a
      majority of disinterested Directors, approval by stockholders or
      other equivalent procedural safeguards.


           Certain Business Relationships. Except as set forth elsewhere in
 this Proxy Statement, none of the Nominees is currently, or has been since
 January 1, 1999, involved in any business relationship with the Company or
 any of its subsidiaries.

           Indebtedness of Management.   None of the Nominees has been
 indebted to the Company or any of its subsidiaries since January 1, 1999.

              THE KIRK STOCKHOLDERS RECOMMEND A VOTE "FOR" THE
               NOMINEES OF THE KIRK STOCKHOLDERS DESCRIBED IN
              THE ABOVE PROPOSAL AND NOT VOTE IN FAVOR OF THE
             NOMINEES OF THE BOARD OF DIRECTORS OF THE COMPANY.


 OTHER MATTERS
 -------------

           As previously mentioned in this Proxy Statement, the Kirk
      Stockholders have not yet formulated any specific plans for the
      Company. The Kirk Stockholders, nonetheless, intend to do so well in
      advance of the 2000 Annual Meeting of Stockholders. Because the
      Meeting is typically held in May, the Kirk Stockholders initially
      anticipated a several month planning period. However, in light of the
      Company's decision to move the meeting from May to February, the Kirk
      Stockholders have restructured their timeline and are now in the
      process of formulating specific plans. Once formulated, the Kirk
      Stockholders will communicate such specific plans to their fellow
      shareholders promptly. In addition, the Kirk Stockholders intend to
      continue to have discussions with other stockholders of the Company
      in order to solicit their thoughts as to the future direction that
      should be taken by the Company and, whenever feasible, the Kirk
      Stockholders will incorporate such stockholder suggestions into their
      specific plans. Although the Kirk Stockholders can give no assurance
      that there will be an increase in profitability or stockholder value
      should their Nominees be elected to the Board of Directors or should
      any such specific plans for the Company be implemented, we are,
      nonetheless, convinced that only with a change in the business
      strategy of the Company can stockholders hope to achieve the
      necessary catalyst for increased shareholder value.


           The Kirk Stockholders do not know of any matters that will be
      brought before the Meeting other than the election of Directors.
      However, if any other matter properly comes before the Meeting, it is
      intended that the person named in and acting under the enclosed form
      of WHITE proxy card, or his substitutes, will vote on such matters in
      accordance with the best judgment.

           If you have any questions about the WHITE proxy card or need
      assistance in voting your shares, please contact:


                  CORPORATE INVESTOR COMMUNICATIONS, INC.
                             111 COMMERCE ROAD
                        CARLSTADT, NEW JERSEY 07072
                         TOLL FREE: (877) 842-2404



                                 APPENDIX A

              SECURITIES TRANSACTIONS OF THE KIRK STOCKHOLDERS

                The following table sets forth information with respect to
      all purchases and sales of shares of the Company's Common Stock by
      the Kirk Stockholders. Unless otherwise noted, the price per share
      excludes brokerage commissions and other charges.

           Date                Number of           Purchase Price
           Of Purchase         Shares Purchased    Per Share
           -----------         ----------------    ----------------

                               RANDAL J. KIRK
                               --------------

      6/16/99              11,000              $3.43750
      6/16/99               5,000               3.46870
      6/16/99               2,000               3.40620
      6/16/99               1,200               3.37500
      6/16/99               3,400               3.43750
      6/17/99                 100               3.50000
      6/17/99                 100               3.53120
      6/17/99                 600               3.62500
      6/17/99                 400               3.65620
      6/17/99                 300               3.68750
      6/17/99                 400               3.65620
      6/17/99                 500               3.53120
      6/17/99                 500               3.56250
      6/17/99                 500               3.62500
      6/17/99                 900               3.53120
      6/17/99               5,000               3.65620
      6/17/99               1,500               3.53120
      6/17/99              15,200               3.65620
      6/17/99              15,400               3.62500
      6/17/99               4,000               3.53120
      6/17/99               4,000               3.50000
      6/17/99               2,000               3.56250
      6/17/99               2,000               3.46870
      6/17/99               2,000               3.56250
      6/18/99              28,200               3.71870
      6/18/99              85,500               3.75000
      6/18/99               8,300               3.71870
      6/18/99              19,000               3.78120
      6/21/99              14,000               3.81250
      6/21/99               4,100               3.78120
      6/21/99               3,000               3.75000
      6/21/99               2,000               3.78120
      6/21/99               6,100               3.75000
      6/21/99                 100               3.71870
      6/21/99                 100               3.78120
      6/21/99                 200               3.81250
      6/21/99               2,000               3.75000
      6/21/99               1,700               3.81250
      6/21/99                 800               3.78120
      6/21/99               1,000               3.71870
      6/21/99               1,000               3.78120
      6/21/99               5,000               3.81250
      6/21/99               1,100               3.78120
      6/21/99               1,200               3.75000
      6/21/99               1,300               3.71870
      6/21/99               2,800               3.81250
      6/21/99               1,700               3.71870
      6/21/99               1,700               3.75000
      6/21/99               3,400               3.78120
      6/22/99              12,000               3.78120
      6/23/99                 100               3.75000
      6/23/99               4,000               3.81250
      6/24/99                 400               3.56250
      6/24/99                 600               3.56250
      6/24/99               1,000               3.56250
      6/24/99               1,500               3.56250
      6/24/99               2,500               3.56250
      6/24/99               6,000               3.56250
      6/24/99              12,000               3.65620
      6/25/99              25,000               3.43750
      6/29/99              11,000               3.56250
      6/29/99               1,000               3.53120
      6/30/99              14,000               3.28120
      6/30/99              14,300               3.43750
      6/30/99               1,000               3.28120
      6/30/99                 700               3.43750
      7/1/99                5,000               3.59370
      7/1/99               13,000               3.56250
      7/1/99                1,000               3.59370
      7/1/99                1,000               3.56250
      7/1/99                2,000               3.59370
      7/1/99                1,000               3.56250
      7/2/99                2,600               3.75000
      7/2/99               10,700               3.71870
      7/2/99               12,500               3.68750
      7/2/99                8,000               3.65620
      7/2/99               12,300               3.75000
      7/2/99                1,000               3.65620
      7/2/99                1,000               3.65620
      7/2/99                1,000               3.68750
      7/2/99                1,300               3.71870
      7/2/99                1,500               3.75000
      7/2/99                1,500               3.68750
      7/7/99               22,800               3.75000
      7/7/99                9,000               3.68750
      7/8/99                  200               3.71870
      7/8/99                  800               3.75000
      7/8/99                1,000               3.56250
      7/8/99                2,000               3.71870
      7/8/99                1,300               3.75000
      7/8/99                1,600               3.71870
      7/8/99               19,700               3.56250
      7/8/99               34,200               3.71870
      7/8/99                2,000               3.68750
      7/8/99               17,900               3.75000
      7/9/99                  800               3.62500
      7/9/99                1,000               3.68750
      7/9/99                2,000               3.62500
      7/9/99               14,000               3.68750
      7/12/99               7,100               3.93750
      7/13/99               9,600               4.62500
      7/13/99               2,000               4.59370
      7/13/99               4,400               4.75000
      7/13/99               2,000               4.18750
      7/13/99               3,400               4.62500
      7/13/99               1,000               4.68750
      7/13/99                 700               4.71870
      7/13/99               1,000               4.18750
      7/13/99               1,000               4.59370
      7/13/99               3,000               4.62500
      7/13/99               5,900               4.75000
      7/14/99              40,000               5.00000
      7/16/99              73,000               5.03120
      7/16/99              16,400               5.06250
      7/16/99              10,000               5.06250
      7/16/99              12,000               5.06250
      7/16/99               2,000               5.06250
      7/16/99              17,600               5.06250
      7/16/99               2,900               5.06250
      7/16/99               9,600               5.06250
      7/16/99               5,000               5.06250
      7/16/99               4,000               5.06250
      7/16/99               5,500               5.06250
      7/16/99               3,000               5.06250
      7/16/99              12,000               5.06250
      7/16/99              25,000               5.06250
      7/16/99               6,000               5.06250
      7/16/99               5,000               5.06250
      7/16/99               2,800               5.06250
      7/16/99               4,000               5.06250
      7/16/99               3,000               5.06250
      7/16/99               2,000               5.06250
      7/16/99                 300               5.06250
      7/16/99               1,000               5.03120
      7/16/99               1,000               5.01560
      7/16/99               1,900               5.06250
      7/19/99              20,200               5.01560
      7/19/99               5,300               5.03120
      7/19/99               5,000               5.03120
      7/19/99               6,400               5.03120
      7/19/99              13,000               5.03120
      7/19/99               2,600               5.03120
      7/19/99               9,600               5.03120
      7/19/99               6,800               5.03120
      7/19/99              35,000               5.00000
      7/19/99               5,900               5.03120
      7/19/99               3,000               5.03120
      7/19/99               3,000               5.03120
      7/19/99               2,000               5.03120
      7/19/99               3,000               5.03120
      7/19/99              10,000               5.03120
      7/19/99               2,000               5.03120
      7/19/99               2,000               5.03120
      7/19/99                 100               5.03120
      7/19/99                 200               5.03120
      7/19/99                 200               5.03120
      7/19/99                 300               5.03120
      7/19/99                 300               5.03120
      7/19/99                 300               5.03120
      7/19/99                 500               5.03120
      7/19/99                 500               5.03120
      7/19/99                 500               5.03120
      7/19/99                 600               5.03120
      7/19/99                 700               5.03120
      7/19/99                 700               5.03120
      7/19/99                 800               5.03120
      7/19/99                 900               5.03120
      7/19/99                 900               5.03120
      7/19/99               1,000               5.01560
      7/19/99               1,000               5.03120
      7/19/99               1,000               5.03120
      7/19/99               1,000               5.03120
      7/19/99               1,000               5.03120
      7/19/99               1,000               5.03120
      7/19/99               1,000               5.03120
      7/19/99               1,000               5.03120
      7/19/99               1,000               5.03120
      7/19/99               1,300               5.03120
      7/19/99               1,700               5.03120
      7/19/99               1,800               5.01560
      7/19/99               1,900               5.03120
      7/20/99              15,700               4.62500
      7/20/99               2,000               4.59370
      7/20/99               2,500               4.62500
      7/20/99               1,800               4.62500
      7/20/99                 200               4.62500
      7/20/99                 700               4.56250
      7/20/99               3,500               4.75000
      7/20/99              28,000               4.81250
      7/20/99              10,500               4.75000
      7/20/99              10,000               4.96870
      7/20/99                 500               4.81250
      7/20/99                 700               4.56250
      7/20/99               5,000               4.81250
      7/20/99                 600               4.78120
      7/20/99               1,000               4.68750
      7/20/99               1,500               4.78120

      RANDAL J. KIRK'S
      TOTAL:            1,136,600
                        =========

      Date                Number of           Purchase Price
      Of Purchase         Shares Purchased    Per Share
      -----------         ----------------    --------------

                          RJK, L.L.C.
                          -----------

      6/22/99               2,900              $3.71870
      6/22/99                 100               3.68750
      6/22/99               2,000               3.71870
      6/23/99                 300               3.87500
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               1,000               3.84370
      6/23/99               5,700               3.87500
      6/23/99               2,000               3.81250
      6/23/99               6,700               3.87500
      6/25/99              12,000               3.50000
      6/25/99               5,000               3.56250
      6/25/99               2,000               3.56250
      6/25/99               8,200               3.56250
      6/25/99               2,100               3.56250
      6/25/99                 100               3.62500
      6/25/99                 100               3.62500
      6/25/99                 100               3.62500
      6/25/99                 200               3.56250
      6/25/99                 300               3.56250
      6/25/99                 500               3.56250
      6/25/99                 500               3.56250
      6/25/99                 500               3.56250
      6/25/99                 500               3.62500
      6/25/99                 500               3.56250
      6/25/99                 700               3.56250
      6/25/99               1,000               3.56250
      6/25/99               1,000               3.56250
      6/25/99               1,200               3.56250
      6/25/99               1,300               3.56250
      6/28/99               1,800               3.50000
      6/28/99              12,000               3.56250
      6/28/99               8,200               3.50000
      6/29/99               2,000               3.59370
      6/29/99               2,400               3.56250
      6/29/99               2,000               3.56250
      6/29/99               7,000               3.56250
      6/29/99               2,000               3.56250
      6/29/99               3,000               3.56250
      6/29/99               2,000               3.56250
      6/29/99               9,800               3.56250
      6/29/99               2,000               3.56250
      6/29/99               6,000               3.56250
      6/29/99               2,000               3.56250
      6/29/99               7,000               3.56250
      6/29/99               2,000               3.56250
      6/29/99               4,000               3.56250
      6/29/99                 100               3.53120
      6/29/99                 100               3.56250
      6/29/99                 100               3.56250
      6/29/99                 200               3.56250
      6/29/99                 500               3.56250
      6/29/99                 500               3.56250
      6/29/99                 500               3.56250
      6/29/99                 500               3.56250
      6/29/99               1,000               3.56250
      6/29/99               1,000               3.56250
      6/29/99               1,000               3.56250
      6/30/99               6,400               3.28120
      6/30/99               2,000               3.28120
      6/30/99               2,000               3.28120
      6/30/99               2,000               3.28120
      6/30/99               4,400               3.43750
      6/30/99              10,000               3.43750
      6/30/99              13,000               3.43750
      6/30/99               2,000               3.43750
      6/30/99              13,000               3.50000
      6/30/99               2,000               3.50000
      6/30/99               3,000               3.50000
      6/30/99               3,000               3.50000
      6/30/99               3,000               3.50000
      6/30/99               2,000               3.50000
      6/30/99               6,000               3.56250
      6/30/99               6,000               3.56250
      6/30/99               3,000               3.56250
      6/30/99               5,000               3.56250
      6/30/99               2,000               3.56250
      6/30/99              10,400               3.59370
      6/30/99                 100               3.46870
      6/30/99                 100               3.50000
      6/30/99                 100               3.59370
      6/30/99                 500               3.46870
      6/30/99                 500               3.56250
      6/30/99                 600               3.28120
      6/30/99                 600               3.28120
      6/30/99                 900               3.50000
      6/30/99               1,000               3.56250
      6/30/99               1,400               3.28120
      7/1/99                8,100               3.56250
      7/1/99                  600               3.31250
      7/1/99                1,300               3.56250
      7/2/99                3,000               3.75000
      7/2/99               11,000               3.75000
      7/2/99                3,200               3.75000
      7/2/99                2,000               3.75000
      7/2/99                2,500               3.71870
      7/2/99                3,700               3.71870
      7/2/99                2,000               3.71870
      7/2/99                4,800               3.68750
      7/2/99                2,000               3.68750
      7/2/99                1,000               3.62500
      7/2/99                1,000               3.62500
      7/2/99                1,000               3.62500
      7/2/99                1,000               3.62500
      7/2/99                1,000               3.62500
      7/2/99                1,000               3.71870
      7/2/99                2,400               3.75000
      7/2/99                  200               3.68750
      7/2/99                  100               3.71870
      7/6/99                2,700               3.75000
      7/6/99                2,000               3.75000
      7/6/99                2,000               3.75000
      7/6/99                2,000               3.75000
      7/6/99                2,700               3.75000
      7/6/99                2,000               3.75000
      7/6/99                2,000               3.75000
      7/6/99                2,000               3.75000
      7/6/99                  300               3.75000
      7/6/99                  300               3.75000
      7/6/99                  500               3.75000
      7/6/99                  500               3.75000
      7/6/99                1,000               3.75000
      7/6/99                1,000               3.75000
      7/6/99                1,000               3.75000
      7/6/99                1,000               3.75000
      7/6/99                1,000               3.75000
      7/6/99                1,100               3.75000
      7/6/99                1,900               3.75000
      7/7/99                  900               3.78120
      7/7/99                  500               3.75000
      7/7/99                  500               3.78120
      7/7/99                  500               3.78120
      7/7/99                  600               3.78120
      7/7/99                1,300               3.78120
      7/7/99                2,000               3.78120
      7/7/99                2,200               3.78120
      7/7/99                4,100               3.78120
      7/7/99                2,000               3.78120
      7/7/99                2,100               3.78120
      7/7/99                2,200               3.78120
      7/7/99                5,000               3.68750
      7/7/99               11,500               3.75000
      7/9/99               11,500               3.81250
      15/99                 1,000               5.15620
      7/15/99               2,000               5.18750

    RJK, L.L.C.'S TOTAL:  387,000
                          =======

    Date                Number of           Purchase Price
    Of Purchase         Shares Purchased    Per Share
    -----------         ----------------    --------------

                        KIRKFIELD, L.L.C.
                        -----------------

      6/22/99                 200              $3.75000
      6/22/99                 300               3.75000
      6/22/99               1,000               3.75000
      6/22/99               2,500               3.75000
      6/22/99               2,000               3.75000
      6/22/99               4,700               3.75000
      6/22/99               4,100               3.75000
      6/22/99               3,500               3.75000
      6/22/99               5,800               3.75000
      6/22/99               7,300               3.75000
      6/22/99               2,000               3.75000
      6/22/99               7,300               3.75000
      6/22/99               2,000               3.75000
      6/23/99                 100               3.75000
      6/23/99                 200               3.78120
      6/23/99               1,000               3.75000
      6/23/99                 500               3.81250
      6/23/99                 900               3.75000
      6/23/99               3,100               3.81250
      6/23/99               2,800               3.75000
      6/23/99               1,400               3.81250
      6/23/99               3,500               3.75000
      6/23/99               4,300               3.81250
      6/23/99               3,000               3.75000
      6/25/99                 100               3.50000
      6/25/99                 100               3.46870
      6/25/99               2,000               3.59370
      6/25/99               1,000               3.56250
      6/25/99               1,000               3.53120
      6/25/99                 600               3.62500
      6/25/99               1,300               3.59370
      6/25/99                 900               3.50000
      6/25/99               2,000               3.62500
      6/25/99               1,000               3.53120
      6/28/99               1,000               3.56250
      6/28/99               2,000               3.53120
      6/30/99              15,000               3.28120
      6/30/99              25,000               3.43750
      6/30/99               9,000               3.50000
      6/30/99               8,900               3.56250
      6/30/99               7,000               3.53120
      6/30/99                 300               3.50000
      6/30/99                 400               3.43750
      6/30/99                 400               3.53120
      6/30/99                 500               3.50000
      6/30/99                 600               3.43750
      6/30/99                 800               3.50000
      6/30/99               2,900               3.43750
      6/30/99               1,000               3.53120
      6/30/99               1,100               3.43750
      6/30/99               1,100               3.56250
      6/30/99               1,400               3.50000
      6/30/99               1,600               3.53120
      7/1/99                3,900               3.62500
      7/1/99                2,000               3.62500
      7/1/99                6,100               3.43750
      7/2/99               12,900               3.75000
      7/2/99                2,000               3.71870
      7/2/99                8,300               3.68750
      7/2/99                6,700               3.65620
      7/2/99                  500               3.75000
      7/2/99                  600               3.75000
      7/2/99                  600               3.75000
      7/2/99                  900               3.75000
      7/2/99                1,000               3.75000
      7/6/99                3,100               3.75000
      7/6/99                2,000               3.75000
      7/6/99                3,400               3.75000
      7/6/99                2,000               3.75000
      7/6/99                2,000               3.75000
      7/6/99                2,500               3.75000
      7/6/99                  100               3.75000
      7/6/99                  100               3.75000
      7/6/99                  500               3.75000
      7/6/99                  500               3.75000
      7/6/99                  500               3.75000
      7/6/99                  600               3.75000
      7/6/99                  600               3.75000
      7/6/99                  600               3.75000
      7/6/99                  600               3.75000
      7/6/99                  900               3.75000
      7/6/99                1,000               3.75000
      7/6/99                1,000               3.75000
      7/6/99                1,100               3.75000
      7/6/99                1,400               3.75000
      7/6/99                1,500               3.75000

      KIRKFIELD, L.L.C.'S
      TOTAL:              225,000
                          =======


      Date                Number of           Purchase Price
      Of Purchase         Shares Purchased    Per Share
      -----------         ----------------    --------------

                      THE KIRK FAMILY INVESTMENT PLAN
                      -------------------------------

      7/12/99              2,000               $3.93750
      7/12/99              2,000                3.93750
      7/12/99              2,000                3.93750
      7/12/99              2,800                3.93750
      7/12/99              2,000                3.93750
      7/12/99                200                3.93750
      7/12/99              1,000                3.90620
      7/12/99              3,000                3.93750
      7/13/99             26,000                4.62500
      7/13/99             10,000                4.59370
      7/13/99             10,800                4.62500
      7/13/99              5,000                4.56250
      7/13/99              3,200                4.68750
      7/13/99              2,000                4.75000
      7/13/99                300                4.59370
      7/13/99                600                4.62500
      7/13/99                500                4.59370
      7/13/99              3,000                4.62500
      7/13/99                800                4.68750
      7/13/99              1,600                4.75000
      7/13/99                900                4.71870
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.62500
      7/13/99              1,000                4.68750
      7/13/99              1,000                4.68750
      7/13/99              1,000                4.75000
      7/13/99              1,000                4.75000
      7/13/99              1,200                4.59370
      7/13/99              3,100                4.62500
      7/14/99             10,000                5.00000
      7/14/99              2,000                5.03120
      7/14/99             15,000                5.00000
      7/15/99             13,300                5.06250
      7/15/99             30,000                5.03120
      7/15/99                900                5.06250
      7/15/99              4,000                5.03120
      7/15/99              1,000                5.06250
      7/15/99              2,000                5.12500
      7/15/99              1,200                5.06250
      7/16/99             32,000                5.06250
      7/16/99              3,100                5.04680
      7/16/99              2,300                5.03120
      7/16/99             12,400                5.04680
      7/16/99              2,000                5.06250
      7/16/99              4,700                5.00000
      7/16/99             18,300                5.06250

      KFIP'S TOTAL:      251,400
                         =======




                      [BACK COVER OF PROXY STATEMENT]


                                 IMPORTANT

      Your vote is important. No matter how many or how few shares of Scios
      you own, please vote FOR the Kirk Stockholders' nominees and AGAINST
      the incumbent Board by signing, dating and mailing the enclosed WHITE
      proxy card.

      Please do not send back any gold proxy card you receive from the
      Company. If you have already done so, you have every right to change
      your vote by signing and returning the enclosed WHITE proxy card.
      Only your latest dated, properly executed proxy card will count.

      If you own your shares in the name of a brokerage firm, your broker
      cannot vote such shares unless he receives your specific
      instructions. Please sign, date and return the enclosed WHITE proxy
      card in the postage-paid envelope that has been provided.

      If you have any questions as to how to vote your shares, please call
      our proxy solicitor:

                  Corporate Investor Communications, Inc.
                             111 Commerce Drive
                            Carlstadt, NJ 07072
                         Toll free: (877) 842-2404



                              PRELIMINARY COPY

                                DETACH HERE


                                 SCIOS INC.
                       ANNUAL MEETING OF STOCKHOLDERS
                      TO BE HELD ON FEBRUARY 28, 2000


                    THIS PROXY IS SOLICITED ON BEHALF OF
                               RANDAL J. KIRK
                                RJK, L.L.C.
                             KIRKFIELD, L.L.C.
                      THE KIRK FAMILY INVESTMENT PLAN
                  (COLLECTIVELY, THE "KIRK STOCKHOLDERS")

           The undersigned hereby appoints Randal J. Kirk, with full power
      of substitution, as proxy of the undersigned, to attend the Annual
      Meeting of Stockholders of Scios Inc., to be held on February 28,
      2000 at a time and site to be selected by the Company, and at any
      adjournment or postponement thereof, to vote the number of shares the
      undersigned would be entitled to vote if personally present, and to
      vote in his discretion upon any other business that may properly come
      before the meeting.

           THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED IN THE MANNER
      DIRECTED HEREIN.  IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED
      FOR PROPOSAL 1.

           Please sign, date and return this proxy in the envelope
      provided, which requires no postage if mailed in the United States.



                                                   --------------------
                                                       SEE REVERSE
      CONTINUED AND TO BE SIGNED ON REVERSE SIDE           SIDE
                                                   --------------------



      PLEASE MARK  / X / VOTES AS IN THIS EXAMPLE
      ----------------------------------------------------------------------
      THE KIRK STOCKHOLDERS RECOMMEND A VOTE FOR PROPOSAL 1.
      ----------------------------------------------------------------------


      1.   Election of Directors.
           NOMINEES: John H. Greist, M.D., Larry D. Horner, Kurt P. Kalm,
                     Randal J. Kirk, Domenic A. Sica, M.D., John P. Szlasa,
                     William E. Yelle

      FOR ALL NOMINEES  / /
      WITHHOLD ALL NOMINEES  / /
      FOR ALL NOMINEES EXCEPT AS NOTED BELOW:


      ---------------------------------------------------------------------


      MARK HERE IF YOU PLAN TO ATTEND THE MEETING  /     /
      MARK HERE FOR ADDRESS CHANGE AND NOTE BELOW  /     /

      (Please sign exactly as name appears. When shares are held by joint
      tenants, both should sign. When signing as attorney, executor,
      administrator, trustee or guardian, please give full title as such.
      If a corporation, please sign in full corporate name by President or
      other authorized officer. If a partnership, please sign in
      partnership name by authorized person.)


      Signature:___________________________________________  Date:_______


      Signature:___________________________________________  Date:_______





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