SCIOS INC
8-K, 2000-01-24
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                              WASHINGTON, DC  20549

                                 ----------------

                                    FORM 8-K

                                 CURRENT REPORT

                       PURSUANT TO SECTION 13 OR 15(D) OF

                        THE SECURITIES EXCHANGE ACT OF 1934


        Date of report (Date of earliest event reported) January 12, 2000


                                       SCIOS INC.
                   (Exact Name of Registrant as Specified in Charter)



         Delaware                   0-11749                   95-3701481
(State of Other Jurisdiction      (Commission               (IRS Employer
        of Incorporation)         File Number)            Identification No.)



               820 West Maude Avenue, Sunnyvale, California 94086
                     (Address of Principal Executive Offices)



       Registrant's telephone number, including area code  (408) 616-8200

<PAGE>

Item 5.  Other Events

     On January 12, 2000, Scios Inc. announced its Board of Directors had
adopted a retention program applicable to all employees. The program is
intended to encourage employees to remain with the Company despite the potential
instability and uncertainty created by the proxy contest threatened by Randal J.
Kirk.

     The program  provides  that any  employee who is  involuntarily  terminated
without  cause or who  voluntarily  terminates  his or her  employment  for good
reason within 12 months after a change of control is entitled to a lump sum cash
payment and continuation of health benefits based on the employee's level within
the Company.  The program will expire if a change of control has not occurred by
December 31, 2001,  unless  extended by the Board. A change of control under the
program  includes  significant  changes in the  ownership  of the Company due to
change of control  transactions as well as a change in a majority of the current
Board.

        The program  consists of agreements specific to six groups of employees.
Copies of the agreements are attached as exhibits.

Exhibits.

        99.1    Press Release dated January 12, 2000

        99.2    Scios Inc. Change of Control Severance Plan:
                Levels 0-17

        99.3    Scios Inc. Change of Control Severance Plan:
                Level 12 PPR (Psychiatric Sales Representatives)

        99.4    Scios Inc. Change of Control Severance Plan:
                Levels 18-20

        99.5    Scios Inc. Change of Control Severance Plan:
                Levels 21-24

        99.6    Form of Scios Inc. Change of Control Severance Plan:
                Corporate Officers

        99.7    Form of Scios Inc. Change of Control Severance Plan:
                Chief Executive Officer

     Pursuant to the  requirements of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this amendment  to be signed on its behalf of the
undersigned, thereunto duly authorized.

                                        SCIOS INC.

                                                /S/
Date:  January 24, 2000                 By:____________________________
                                                John H. Newman
                                                Senior Vice President,
                                                General Counsel and Secretary
<PAGE>

                                INDEX TO EXHIBITS

                                    SCIOS INC.

                     Report on Form 8-K dated January 24, 2000




Exhibit     Description                           Method of Filing

99.1        Press Release dated January 12, 2000  Filed electronically herewith

99.2        Scios Inc. Change of Control          Filed electronically herewith
            Severance Plan: Levels 0-17

99.3        Scios Inc. Change of Control          Filed electronically herewith
            Severance Plan: Level 12 PPR
            (Psychiatric Sales Representatives)

99.4        Scios Inc. Change of Control          Filed electronically herewith
            Severance Plan: Levels 18-20

99.5        Scios Inc. Change of Control          Filed electronically herewith
            Severance Plan: Levels 21-24

99.6        Form of Scios Inc. Change of Control  Filed electronically herewith
            Severance Plan: Corporate Officers

99.7        Scios Inc. Change of Control          Filed electronically herewith
            Severance Plan: Chief Executive
            Officer





                                                                    EXHIBIT 99.1

                                [SCIOS LETTERHEAD]

CONTACT:
Wendy Carhart
Scios Inc.
408/616-8325
or
Stanley J. Kay
MacKenzie Partners, Inc.
212/929-5940

FOR IMMEDIATE RELEASE:

                  SCIOS BOARD ADOPTS EMPLOYEE RETENTION PROGRAM

SUNNYVALE,  CALIFORNIA - January 12, 2000 - Scios Inc. (NASDAQ:  SCIO) announced
today  that its Board of  Directors  has  adopted a two-year  retention  program
applicable to all employees.  The program is intended to encourage  employees to
remain  with the Company  despite  the  potential  instability  and  uncertainty
created by the proxy contest threatened by Randal J. Kirk.

"The Scios  Board  believes  it is in the best  interests  of the  Company,  its
stockholders  and its employees to adopt a retention  program for all our valued
employees to ensure their  continued  commitment as Scios moves forward with our
focused new business plan," said Donald B. Rice, Ph.D., Chairman of Scios' Board
of  Directors.  "Following  the  strides  Scios  made  under its new  leadership
throughout the past year, the Board felt this short-term action was necessary to
minimize the impact of the threatened  proxy fight and the inherent  distraction
it could cause.  Our retention  program was thoroughly  reviewed to make certain
that it is consistent with similar programs."

"Retaining  our  scientists,  researchers,  and other  staff is  critical to our
Natrecor  and  p38-kinase  inhibitor  programs  - the  two key  products  in our
pipeline."  added  Richard B. Brewer,  President  and Chief  Executive  Officer.
"Considering how  highly-competitive  the market is for skilled employees in our
industry,  the entire Board  believes it is important at this  critical  time to
provide our employees with appropriate protection and incentives."

                                   -- more --

<PAGE>

                                                                January 12, 2000
                                                                          Page 2

The program provides that any employee who is involuntarily  terminated  without
cause or who voluntarily terminates his or her employment for good reason within
12 months  after a change of control is entitled to a lump sum cash  payment and
continuation  of  health  benefits  based on the  employee's  level  within  the
Company.  The program  will  expire if a change of control  has not  occurred by
December 31, 2001,  unless  extended by the Board. A change of control under the
program  includes  significant  changes in the  ownership  of the Company due to
change of control  transactions as well as a change in a majority of the current
Board.

Scios Inc.

Scios is a biopharmaceutical company engaged in the discovery,  development, and
commercialization of novel human therapeutics.  Scios has commercial or research
and   development   relationships   with   Chiron   Corporation,    The   DuPont
Pharmaceuticals   Company,   Eli  Lilly  and   Company,   GenVec   Inc.,   Kaken
Pharmaceutical  Co., Ltd., and Novo Nordisk A/S of Denmark.  Scios'  Psychiatric
Sales and Marketing Division  successfully  markets seven psychiatric  products,
including  co-promotion  arrangements  on Janssen  Pharmaceutica's  Risperdal(R)
(risperidone)  and SmithKline  Beecham's  Paxil(R)  (paroxetine  hydrochloride).
Additional  information  on  Scios  is  available  at its web  site  located  at
www.sciosinc.com  and in the Company's  various  filings with the Securities and
Exchange Commission.  For information about the Year 2000 Annual Meeting,  visit
www.sciosinc.com/election.




                                                                    EXHIBIT 99.2

[Scios Logo]

To:      Scios Employees in Levels 0-17
From:    The Board of Directors
Re:      Scios Inc. Change of Control Severance Plan:  Levels 0-17
Date:    January 11, 2000



         The Board of  Directors  of the  Company  has  approved  the Scios Inc.
Change of Control  Severance  Plan:  Levels  0-17 (the  "Plan")  which  provides
certain severance benefits for you, effective immediately, in the event that you
lose your job as a result of a change of control of Scios  Inc.  that  occurs at
any time on or after  January 11, 2000 and on or prior to December 31, 2001 (the
"Plan Term").

         All words  that  appear in italics in this  memorandum  are  defined in
Attachment A to this memorandum.

         Severance Benefits. If your employment is involuntarily  terminated for
any  reason  (other  than for  Cause,  your  death or your  Disability),  or you
voluntarily  terminate your employment for Good Reason,  in either case,  within
365 days on or after a Change of Control  occurring  during  the Plan Term,  you
will be entitled to receive the following payments and benefits:

                  (a) A lump  sum  severance  payment  equal to two  times  your
weekly  Compensation  for each full year you have been  employed by the Company;
provided  that your  minimum  severance  payment  will be equal to 12 times your
weekly Compensation. The severance amount to which you are entitled will be paid
to you in cash  within  15  calendar  days  after the date  your  employment  is
terminated and your general release described below becomes irrevocable.

                  (b) Payment by the Company for up to three months of COBRA for
continuation of health care benefits  (including any medical,  dental and vision
coverage)  for you and your  dependents  under the same  plans or  substantially
similar plan(s) established by the Company or its subsidiaries thereafter.  Such
health  coverage  will be paid for by the Company  only to the same extent as if
you were still employed by the Company, and you will be required to pay for such
health  benefits  to the same  extent that you would be required to do so if you
were still  employed by the Company.  These  benefits will terminate on the date
you become  covered  under any other  group  health plan not  maintained  by the
Company or its  subsidiaries  which provides equal or greater benefits than such
plan and which does not  exclude  any  pre-existing  condition  that you or your
dependents may have at that time.

                (c) Provision of outplacement  services by an organization
selected by the Company up to a maximum cost of $1,800.

<PAGE>

         Withholding  of  Taxes.  The  Company  will  withhold  from  any of the
foregoing  amounts  payable  to you all  federal,  state,  city or  other  taxes
required by applicable law to be withheld by the Company.

         Other Benefits.  The severance  benefits described here are intended to
be provided in lieu of and to replace  any  similar or  duplicative  benefits to
which you may be entitled  from the Company or its  subsidiaries  in  connection
with the  termination  of your  employment  after a Change of Control  occurring
during  the Plan Term  under  any other  severance  plan,  agreement,  policy or
program.  This Plan does not  obligate  the  Company to provide you or any other
employees  with any  severance  benefits  if your  employment  terminates  under
circumstances not covered by this Plan. However,  this is not intended to reduce
any amounts  otherwise  payable,  or in any way  diminish  your rights under any
incentive,  retirement,  pension, profit sharing, stock purchase or benefit plan
or other  arrangement  not related to  severance  following a Change of Control.
These  severance  benefits  will not affect  your  rights to any stock  options,
restricted stock or other equity interests  granted by the Company now or in the
future.

         No Employment.  This Plan is not an employment agreement and nothing in
this Plan requires you to stay in the  employment  of the Company,  requires the
Company to retain you in your present position or any other position, or changes
the status of your employment at will.

         No Setoff.  The Company's  obligation to make severance payments to you
under this Plan and otherwise to perform its obligations will not be affected by
any  circumstances,  including,  but not limited  to, any setoff,  counterclaim,
recoupment,  defense or other right which the  Company or its  subsidiaries  may
have against you or others.

         Claims and Disputes.  You will have the right (but not the  obligation)
to  elect  (in  lieu of  litigation)  to have any  dispute  arising  under or in
connection  with this Plan which is not  otherwise  resolved  through the claims
procedure  described in  Attachment B settled by  arbitration,  conducted by one
arbitrator  sitting in a location  selected by you within  fifty (50) miles from
the  location of your job with the Company in  accordance  with the rules of the
American Arbitration Association then in effect. Judgement may be entered on the
award of the  arbitrator  in any  court  having  jurisdiction.  All  arbitration
expenses,  including all attorney  fees incurred in good faith,  will be paid by
the  Company.  You shall be  conclusively  presumed  to have acted in good faith
unless and until the arbitrator makes a final determination to the contrary.

         Legal  Fees.  If the  Company  refuses or fails to provide you with any
severance  benefits under this Plan or contests the validity of the Plan or your
rights to  benefits,  the Company  will pay, as they become due, all legal fees,
costs of litigation and other expenses  incurred in good faith by you. You shall
be  conclusively  presumed  to have acted in good faith  unless a court  makes a
final determination not otherwise subject to appeal to the contrary.

         Notice of Termination.  Following a Change of Control  occurring during
the Plan Term, any purported  termination  of your  employment by the Company or
its subsidiaries shall be communicated by written notice which will indicate, if
it is based on Cause,  the specific  reasons relied upon and which sets forth in
reasonable  detail  the facts and  circumstances  claimed to provide a basis for
termination for Cause.

<PAGE>

         Term.  This  Plan will  expire on the last day of the Plan Term  (i.e.,
December 31,  2001) if a Change of Control has not  occurred by that date.  If a
Change of Control  occurs on or before  that  date,  the Plan will  continue  in
effect and not expire until 366 calendar days from and including the date of the
Change of  Control,  at which  time the Plan will  expire  except if you  become
entitled to the severance  benefits  described  above prior to such time. If you
become entitled to severance  benefits,  the Plan will continue until you or any
other person  covered  have  received in full all  severance  payments and other
benefits due.

         Amendment.  This Plan may not be terminated or amended in any manner
which may adversely affect your rights under it, unless you expressly agree.

         Successor.  The Company will require any successor to its business or
substantially all of its assets to assume and agree to perform the Company's
obligations to you under this Plan.

         ERISA. This Plan is subject to the Employee  Retirement Income Security
Act of 1974, as amended ("ERISA").  See Attachment B, which is part of the Plan,
for a statement  of certain  Plan  information  and the rules  applicable  under
ERISA.

         General Release.  A condition to your receipt of any severance payments
under this Plan will be your  execution and delivery (and the  expiration of any
applicable  revocability  period given by law) of a general release as described
in Attachment C in a form reasonably  satisfactory  to the Company.  The release
will also have (a) appropriate  provisions  necessary to insure that it is valid
and  enforceable  under  applicable  laws,  including the Older Workers  Benefit
Protection  Act and (b) a waiver of  California  Civil Code  Section 1542 (which
provides that unless you  specifically  agree to release  claims you do not know
about,  they are not  released  by a general  release).  Your  payments  will be
considered independent consideration made in exchange for your release.

         We believe this Plan will help satisfy some of the concern you may have
in this uncertain  period.  If you have any questions  about your benefits under
this Plan, please call Lauretta C. Cesario at (408) 616-8306.

                                                     Sincerely,

                                                     /s/

                                                     Richard B. Brewer
                                                     President and CEO

<PAGE>

                                    Exhibit A

                                   Definitions

         Whenever used in this memorandum,  the following  italicized words have
the meanings set forth below:

"Cause" means a termination  for any of the following  reasons:  (i) engaging in
intentional  misconduct  which  would  tend to  discredit  the  Company  or your
position;  (ii) being  convicted of a felony;  (iii)  committing an act of fraud
against  the  Company  or the  willful  material  misappropriation  of  property
belonging to the Company; (iv) materially breaching any proprietary  information
agreement between you and the Company or (v) willfully  disregarding your duties
despite adequate warnings from the Company.

"Change of Control" of the Company means and includes any of the following:

               o    "Any  person" or "group"  (as those terms are defined in the
                    Securities  Exchange Act of 1934, as amended (the  "Exchange
                    Act") and the rules and regulations  promulgated thereunder)
                    is or  becomes,  on or  prior  to  December  31,  2001,  the
                    "beneficial  owner  (as  defined  in Rule  13d-3  under  the
                    Exchange Act)", directly or indirectly, of securities of the
                    Company  representing  fifty  percent  (50%)  or more of the
                    voting power of then outstanding securities of the Company.

               o    Any person or group is or  becomes,  on or prior to December
                    31, 2001, the beneficial owner,  directly or indirectly,  of
                    securities of the Company  representing twenty percent (20%)
                    or  more  of  the  voting  power  of  the  then  outstanding
                    securities  of the  Company,  unless  such  acquisition  was
                    approved in advance by the Company's Board of Directors.

               o    The individuals  who, as of the date hereof,  are members of
                    the Company's Board of Directors (the "Existing Directors"),
                    cease, on or prior to December 31, 2001, for any reason,  to
                    constitute  more than fifty  percent  (50%) of the number of
                    authorized  directors  of the Company as  determined  in the
                    manner   prescribed   in  the   Company's   Certificate   of
                    Incorporation  and Bylaws;  provided,  however,  that if the
                    appointment, or the election, or nomination for election, by
                    the Company's stockholders of any new director, was approved
                    by a vote of at least fifty  percent  (50%) of the  Existing
                    Directors, such new director shall be considered an Existing
                    Director;  provided  further,  however,  that no  individual
                    shall be considered an Existing  Director if such individual
                    initially  assumed office as a result of either an actual or
                    threatened election contest (as described in Rule 14a-11 or,
                    effective January 24, 2000, Rule 14a-12(c) promulgated under
                    the Exchange Act) or other actual or threatened solicitation
                    of proxies by or on behalf of anyone other than the Board of
                    Directors  (a "Proxy  Contest"),  including by reason of any
                    agreement  intended to avoid or settle any election  contest
                    or Proxy Contest.

<PAGE>

               o    The  consummation,  on or prior to December 31,  2001,  of a
                    merger, consolidation or reorganization to which the Company
                    is a  party,  whether  or not  the  Company  is  the  person
                    surviving or resulting  therefrom,  in one  transaction or a
                    series of related transactions,  to any person(s) other than
                    a subsidiary,  provided,  however,  that no such transaction
                    shall  constitute a "Change of Control" under this clause if
                    the  persons  who  were  the  stockholders  of  the  Company
                    immediately  before the consummation of such transaction are
                    the   beneficial   owners,    immediately    following   the
                    consummation of such transaction,  of fifty percent (50%) or
                    more of the combined  voting  power of the then  outstanding
                    voting  securities of the person surviving or resulting from
                    any merger, consolidation or reorganization.

               o    The  consummation,  on or prior to December 31,  2001,  of a
                    sale, assignment,  lease, conveyance or other disposition of
                    50% or more of the assets or assets representing 50% or more
                    of the earning  power of the Company,  in one or a series of
                    related   transactions   to  any  Person(s)   other  than  a
                    Subsidiary.

               o    A complete liquidation of the Company.

"COBRA" means the Consolidated Omnibus Budget Reconciliation Act of 1985.

"Compensation"  means your base salary per week at the time your  employment  is
terminated  attributable  to your  employment with the Company and/or any of its
Subsidiaries  (including,  but not  limited  to, any  amounts  excluded  at your
election  from your gross  income for federal  income tax  purposes  pursuant to
Section 125 or Section 401(k) of the Internal  Revenue Code of 1986, as amended,
or deferred pursuant to any Company or Subsidiary plan or program).

"Disability"  means a physical or mental infirmity which  substantially  impairs
your  ability  to  perform  your  material  duties  for a period of at least one
hundred  eighty  (180)  consecutive  calendar  days  and,  as a  result  of such
Disability,  you have not returned to your full-time regular employment prior to
termination.

 "Good Reason"  means either of the  following:  (i) any material  breach by the
Company of any  provision of this Plan;  or (ii) a reduction in the amount equal
to the sum of (a) your total annual cash salary and (b) your bonus  opportunity,
if any,  in each  case as in  effect  on the date  hereof  or as the same may be
increased from time to time.

<PAGE>

                                  Attachment B

                                ERISA Supplement

          Rules applicable under the Employee Retirement Security Act (ERISA) to
the Scios Inc. Change of Control Severance Plan: Levels 0-17 (the "Plan"):

         Claims  Procedure.  All claims and appeals of denied  claims under this
Plan  shall be  processed  by the Plan  Administrator.  A claim must be filed in
writing  within  90 days of the time it  arises.  The Plan  Administrator  shall
respond  to the  claim  within 90 days  unless a longer  time  period  (up to an
additional  90 days) is  required  and  proper  notice is  given.  If a claim is
denied, a written denial shall be issued which contains the information required
by the Employee  Retirement  Income  Security Act of 1974  (ERISA).  Review of a
denied claim may be requested by written  application to the Plan  Administrator
within 60 days of the denial. The Plan  Administrator  shall complete the review
within 60 days of the request  unless a longer  period (up to an  additional  60
days) is required and proper notice is given. The decision on appeal shall be in
writing  and  shall  contain  the  information   required  by  ERISA.  The  Plan
Administrator  may adopt rules  which  specify  the  procedures  for a claim and
review in more detail and such procedures shall be binding to the same extent as
if originally included in this Plan.

        Information  provided  under ERISA.  This Plan is an unfunded  severance
plan, maintained on a calendar year basis. In addition to constituting the Plan,
this  memorandum,  and  its  attachments,  also  constitutes  the  summary  plan
description  required by ERISA.  The Plan sponsor is Scios Inc.  which bears the
costs of all the benefits under the Plan. The Employer  Identification number of
Scios is  95-3701481;  and the Plan number  assigned  by Scios is 502.  The Plan
Administrator's  name,  business address,  and telephone number are: Scios Inc.,
820 West Maude Avenue,  Sunnyvale,  California 94086,  (408) 616-8200.  The Plan
Administrator is the agent for service of legal process.

         Statement of ERISA Rights.  A  participant  in this Plan is entitled to
certain  rights and  protections  under a federal  law known as  "ERISA."  ERISA
provides  that all Plan  participants  shall be  entitled  to  examine,  without
charge, at the Plan  Administrator's  office,  all Plan documents and the Plan's
annual report.  Copies of these documents and other Plan information may also be
obtained upon written request to the Plan Administrator. A reasonable charge may
be made for copies.

         In addition to creating rights for the Plan participants, ERISA imposes
duties upon the people who are  responsible  for the operation of this Plan. The
people who operate this Plan,  called  "fiduciaries" of the Plan, have a duty to
do so prudently and in the interest of you and other Plan participants.  No one,
including  your  employer,  or any  other  person,  may  fire  you or  otherwise
discriminate  against you in any way to prevent you from  obtaining  benefits or
exercising your rights under ERISA. If your claim benefits is denied in whole or
in part,  you must receive a written  explanation of the reason for this denial.
You have the right to have the Plan  Administrator  review and  reconsider  your
claim, as described elsewhere in this summary plan description.

<PAGE>

         Under ERISA,  there are steps you can take to enforce the above rights,
For  instance,  if you request  materials  from the Plan and do not receive them
within 30 days, you may file suit in a federal court.  In such a case, the court
may require the Plan  Administrator  to provide the  materials and pay you up to
$100 a day until you receive the  materials,  unless the materials were not sent
because of reasons beyond the control of the Plan  Administrator.  If you have a
claim for benefits which is denied or ignored, in whole or in part, you may file
a suit  in a state  or  federal  court.  If you are  discriminated  against  for
asserting  your rights,  you may seek  assistance  from the U.S.  Department  of
Labor, or you may file suit in a federal court. The court will decide who should
pay court costs and legal fees.  If you are  successful  the court may order the
person  you have sued to pay these  costs and fees.  If you lose,  the court may
order you to pay these costs and fees,  for  example,  if it finds your claim is
frivolous.

         If you have any questions  about your Plan, you should contact the Plan
Administrator.  If you have any  questions  about this  statement  or about your
rights  under  ERISA,  you should  contact the  nearest  Area Office of the U.S.
Labor-Management Services Administration, Department of Labor.

         Governing  Law.  The  Plan  shall  be  interpreted,  administered,  and
enforced in  accordance  with ERISA and the rights of the  participants  and all
other person shall be determined in accordance with that law. To the extent that
state  law  is  applicable,  however,  the  substantive  laws  of the  state  of
California shall govern.

<PAGE>

                                  Attachment C

                          Provisions of General Release

         The release  will provide that your  acceptance  of severance  benefits
under the Plan will constitute a full and complete release by you of any and all
claims you may have  against  the  Company,  any of its past,  present or future
stockholders or any of their  respective  officers,  directors,  employees,  and
affiliates (past, present or future),  including, but not limited to, claims you
might have relating to your employment  and/or  cessation of employment with the
Company, including without limitation,  tort, contract and common law claims and
claims under Title VII of the Civil Rights Act of 1964,  the Age  Discrimination
in Employment Act of 1967, the Americans with  Disabilities  Act of 1990, or any
other similar  federal,  state or local statute,  rule or  regulation;  provided
that,  there  shall be  excluded  from the  scope of such  general  release  the
following:

               o    claims   that  you  may  have   against   the   Company  for
                    reimbursement of reasonable and necessary  business expenses
                    incurred by you during the course of your employment;

               o    claims  that  may be  made  by you for  payment  of  accrued
                    salary, stock options,  pension benefits or other continuing
                    benefits as specifically provided for in the Plan.

        The release will also have the provisions set forth in the memorandum.




                                                                    EXHIBIT 99.3
[Scios Logo]

To:      Scios Professional Psychiatric Sales Representatives
From:    The Board of Directors
Re:      Scios Inc. Change of Control Severance Plan:  Level 12 PPR
Date:    January 11, 2000

         The Board of  Directors  of the  Company  has  approved  the Scios Inc.
Change of Control  Severance  Plan:  Level  12-PPR (the "Plan")  which  provides
certain severance benefits for you, effective immediately, in the event that you
lose your job as a result of a change of control of Scios  Inc.  that  occurs at
any time on or after  January 11, 2000 and on or prior to December 31, 2001 (the
"Plan Term").

         All words  that  appear in italics in this  memorandum  are  defined in
Attachment A to this memorandum.

         Severance Benefits. If your employment is involuntarily  terminated for
any  reason  (other  than for  Cause,  your  death or your  Disability),  or you
voluntarily  terminate your employment for Good Reason,  in either case,  within
365 days on or after a Change of Control  occurring  during  the Plan Term,  you
will be entitled to receive the following payments and benefits:

                  (a) A lump  sum  severance  payment  equal to two  times  your
weekly  Compensation  for each full year you have been  employed by the Company;
provided  that your  minimum  severance  payment  will be equal to 12 times your
weekly Compensation. The severance amount to which you are entitled will be paid
to you in cash  within  15  calendar  days  after the date  your  employment  is
terminated and your general release described below becomes irrevocable.

                  (b) Payment by the Company for up to three months of COBRA for
continuation of health care benefits  (including any medical,  dental and vision
coverage)  for you and your  dependents  under the same  plans or  substantially
similar plan(s) established by the Company or its subsidiaries thereafter.  Such
health  coverage  will be paid for by the Company  only to the same extent as if
you were still employed by the Company, and you will be required to pay for such
health  benefits  to the same  extent that you would be required to do so if you
were still  employed by the Company.  These  benefits will terminate on the date
you become  covered  under any other  group  health plan not  maintained  by the
Company or its  subsidiaries  which provides equal or greater benefits than such
plan and which does not  exclude  any  pre-existing  condition  that you or your
dependents may have at that time.

                   (c) Provision of outplacement services by an organization
selected by the Company up to a maximum cost of $1,800.

<PAGE>

         Withholding  of  Taxes.  The  Company  will  withhold  from  any of the
foregoing  amounts  payable  to you all  federal,  state,  city or  other  taxes
required by applicable law to be withheld by the Company.

         Other Benefits.  The severance  benefits described here are intended to
be provided in lieu of and to replace  any  similar or  duplicative  benefits to
which you may be entitled  from the Company or its  subsidiaries  in  connection
with the  termination  of your  employment  after a Change of Control  occurring
during  the Plan Term  under  any other  severance  plan,  agreement,  policy or
program.  This Plan does not  obligate  the  Company to provide you or any other
employees  with any  severance  benefits  if your  employment  terminates  under
circumstances not covered by this Plan. However,  this is not intended to reduce
any amounts  otherwise  payable,  or in any way  diminish  your rights under any
incentive,  retirement,  pension, profit sharing, stock purchase or benefit plan
or other  arrangement  not related to  severance  following a Change of Control.
These  severance  benefits  will not affect  your  rights to any stock  options,
restricted stock or other equity interests  granted by the Company now or in the
future.

         No Employment.  This Plan is not an employment agreement and nothing in
this Plan requires you to stay in the  employment  of the Company,  requires the
Company to retain you in your present position or any other position, or changes
the status of your employment at will.

         No Setoff.  The Company's  obligation to make severance payments to you
under this Plan and otherwise to perform its obligations will not be affected by
any  circumstances,  including,  but not limited  to, any setoff,  counterclaim,
recoupment,  defense or other right which the  Company or its  subsidiaries  may
have against you or others.

         Claims and Disputes.  You will have the right (but not the  obligation)
to  elect  (in  lieu of  litigation)  to have any  dispute  arising  under or in
connection  with this Plan which is not  otherwise  resolved  through the claims
procedure  described in  Attachment B settled by  arbitration,  conducted by one
arbitrator  sitting in a location  selected by you within  fifty (50) miles from
the  location of your job with the Company in  accordance  with the rules of the
American Arbitration Association then in effect. Judgement may be entered on the
award of the  arbitrator  in any  court  having  jurisdiction.  All  arbitration
expenses,  including all attorney  fees incurred in good faith,  will be paid by
the  Company.  You shall be  conclusively  presumed  to have acted in good faith
unless and until the arbitrator makes a final determination to the contrary.

         Legal  Fees.  If the  Company  refuses or fails to provide you with any
severance  benefits under this Plan or contests the validity of the Plan or your
rights to  benefits,  the Company  will pay, as they become due, all legal fees,
costs of litigation and other expenses  incurred in good faith by you. You shall
be  conclusively  presumed  to have acted in good faith  unless a court  makes a
final determination not otherwise subject to appeal to the contrary.

<PAGE>

         Notice of Termination.  Following a Change of Control  occurring during
the Plan Term, any purported  termination  of your  employment by the Company or
its subsidiaries shall be communicated by written notice which will indicate, if
it is based on Cause,  the specific  reasons relied upon and which sets forth in
reasonable  detail  the facts and  circumstances  claimed to provide a basis for
termination for Cause.

         Term.  This  Plan will  expire on the last day of the Plan Term  (i.e.,
December 31,  2001) if a Change of Control has not  occurred by that date.  If a
Change of Control  occurs on or before  that  date,  the Plan will  continue  in
effect and not expire until 366 calendar days from and including the date of the
Change of  Control,  at which  time the Plan will  expire  except if you  become
entitled to the severance  benefits  described  above prior to such time. If you
become entitled to severance  benefits,  the Plan will continue until you or any
other person  covered  have  received in full all  severance  payments and other
benefits due.

         Amendment.  This Plan may not be terminated or amended in any manner
which may adversely affect your rights under it, unless you expressly agree.

         Successor.  The Company will require any successor to its business or
substantially all of its assets to assume and agree to perform the Company's
obligations to you under this Plan.

         ERISA. This Plan is subject to the Employee  Retirement Income Security
Act of 1974, as amended ("ERISA").  See Attachment B, which is part of the Plan,
for a statement  of certain  Plan  information  and the rules  applicable  under
ERISA.

         General Release.  A condition to your receipt of any severance payments
under this Plan will be your  execution and delivery (and the  expiration of any
applicable  revocability  period given by law) of a general release as described
in Attachment C in a form reasonably  satisfactory  to the Company.  The release
will also have (a) appropriate  provisions  necessary to insure that it is valid
and  enforceable  under  applicable  laws,  including the Older Workers  Benefit
Protection  Act and (b) a waiver of  California  Civil Code  Section 1542 (which
provides that unless you  specifically  agree to release  claims you do not know
about,  they are not  released  by a general  release).  Your  payments  will be
considered independent consideration made in exchange for your release.

         We believe this Plan will help satisfy some of the concern you may have
in this uncertain  period.  If you have any questions  about your benefits under
this Plan, please call Lauretta C. Cesario at (408) 616-8306.

                                                     Sincerely,

                                                     /s/

                                                     Richard B. Brewer
                                                     President and CEO

<PAGE>

                                    Exhibit A

                                   Definitions

         Whenever used in this memorandum,  the following  italicized words have
the meanings set forth below:

"Cause" means a termination  for any of the following  reasons:  (i) engaging in
intentional  misconduct  which  would  tend to  discredit  the  Company  or your
position;  (ii) being  convicted of a felony;  (iii)  committing an act of fraud
against  the  Company  or the  willful  material  misappropriation  of  property
belonging to the Company; (iv) materially breaching any proprietary  information
agreement between you and the Company or (v) willfully  disregarding your duties
despite adequate warnings from the Company.

"Change of Control" of the Company means and includes any of the following:

                    o    "Any  person" or "group" (as those terms are defined in
                         the  Securities  Exchange Act of 1934,  as amended (the
                         "Exchange   Act")  and  the   rules   and   regulations
                         promulgated  thereunder) is or becomes,  on or prior to
                         December 31, 2001, the "beneficial owner (as defined in
                         Rule  13d-3  under  the  Exchange  Act)",  directly  or
                         indirectly,  of securities of the Company  representing
                         fifty percent (50%) or more of the voting power of then
                         outstanding securities of the Company.

                    o    Any  person  or  group  is or  becomes,  on or prior to
                         December 31, 2001,  the beneficial  owner,  directly or
                         indirectly,  of securities of the Company  representing
                         twenty percent (20%) or more of the voting power of the
                         then outstanding securities of the Company, unless such
                         acquisition  was  approved in advance by the  Company's
                         Board of Directors.

                    o    The individuals who, as of the date hereof, are members
                         of the  Company's  Board of  Directors  (the  "Existing
                         Directors"),  cease,  on or prior to December 31, 2001,
                         for any reason,  to constitute  more than fifty percent
                         (50%) of the  number  of  authorized  directors  of the
                         Company as determined  in the manner  prescribed in the
                         Company's  Certificate  of  Incorporation  and  Bylaws;
                         provided,  however,  that  if the  appointment,  or the
                         election,  or nomination for election, by the Company's
                         stockholders  of any new  director,  was  approved by a
                         vote of at least fifty  percent  (50%) of the  Existing
                         Directors,  such new director  shall be  considered  an
                         Existing Director;  provided further,  however, that no
                         individual shall be considered an Existing  Director if
                         such individual initially assumed office as a result of
                         either an actual or  threatened  election  contest  (as
                         described  in Rule  14a-11 or,  effective  January  24,
                         2000,  Rule  14a-12(c)  promulgated  under the Exchange
                         Act) or other  actual  or  threatened  solicitation  of
                         proxies by or on behalf of anyone  other than the Board
                         of Directors (a "Proxy  Contest"),  including by reason
                         of any  agreement  intended  to  avoid  or  settle  any
                         election contest or Proxy Contest.

<PAGE>

                    o    The consummation,  on or prior to December 31, 2001, of
                         a merger,  consolidation or reorganization to which the
                         Company is a party,  whether or not the  Company is the
                         person  surviving  or  resulting   therefrom,   in  one
                         transaction or a series of related transactions, to any
                         person(s) other than a subsidiary,  provided,  however,
                         that no such transaction  shall constitute a "Change of
                         Control"  under this clause if the persons who were the
                         stockholders  of the  Company  immediately  before  the
                         consummation  of such  transaction  are the  beneficial
                         owners,  immediately following the consummation of such
                         transaction,  of  fifty  percent  (50%)  or more of the
                         combined  voting power of the then  outstanding  voting
                         securities  of the person  surviving or resulting  from
                         any merger, consolidation or reorganization.

                    o    The consummation,  on or prior to December 31, 2001, of
                         a  sale,   assignment,   lease,   conveyance  or  other
                         disposition  of 50% or more  of the  assets  or  assets
                         representing  50% or more of the  earning  power of the
                         Company, in one or a series of related  transactions to
                         any Person(s) other than a Subsidiary.

                    o    A complete liquidation of the Company.

"COBRA" means the Consolidated Omnibus Budget Reconciliation Act of 1985.

"Compensation"  means your base salary per week at the time your  employment  is
terminated  attributable  to your  employment with the Company and/or any of its
Subsidiaries  (including,  but not  limited  to, any  amounts  excluded  at your
election  from your gross  income for federal  income tax  purposes  pursuant to
Section 125 or Section 401(k) of the Internal  Revenue Code of 1986, as amended,
or deferred  pursuant to any Company or Subsidiary plan or program).  As a Level
12-PPR,  your base  salary per week shall be the average of your weekly pay over
either (1) the 6 month period immediately  preceding your termination or (2) the
6 month  period  immediately  preceding  the  Change of  Control,  whichever  is
greater.

"Disability"  means a physical or mental infirmity which  substantially  impairs
your  ability  to  perform  your  material  duties  for a period of at least one
hundred  eighty  (180)  consecutive  calendar  days  and,  as a  result  of such
Disability,  you have not returned to your full-time regular employment prior to
termination.

 "Good Reason"  means either of the  following:  (i) any material  breach by the
Company of any  provision of this Plan;  or (ii) a reduction in the amount equal
to the sum of (a) your total annual cash salary and (b) your bonus  opportunity,
if any,  in each  case as in  effect  on the date  hereof  or as the same may be
increased from time to time.

<PAGE>

                                  Attachment B

                                ERISA Supplement

         Rules applicable under the Employee Retirement Security Act (ERISA) to
the Scios Inc.  Change of Control Severance Plan: Level 12 PPR (the "Plan"):

         Claims  Procedure.  All claims and appeals of denied  claims under this
Plan  shall be  processed  by the Plan  Administrator.  A claim must be filed in
writing  within  90 days of the time it  arises.  The Plan  Administrator  shall
respond  to the  claim  within 90 days  unless a longer  time  period  (up to an
additional  90 days) is  required  and  proper  notice is  given.  If a claim is
denied, a written denial shall be issued which contains the information required
by the Employee  Retirement  Income  Security Act of 1974  (ERISA).  Review of a
denied claim may be requested by written  application to the Plan  Administrator
within 60 days of the denial. The Plan  Administrator  shall complete the review
within 60 days of the request  unless a longer  period (up to an  additional  60
days) is required and proper notice is given. The decision on appeal shall be in
writing  and  shall  contain  the  information   required  by  ERISA.  The  Plan
Administrator  may adopt rules  which  specify  the  procedures  for a claim and
review in more detail and such procedures shall be binding to the same extent as
if originally included in this Plan.

        Information  provided  under ERISA.  This Plan is an unfunded  severance
plan, maintained on a calendar year basis. In addition to constituting the Plan,
this  memorandum,  and  its  attachments,  also  constitutes  the  summary  plan
description  required by ERISA.  The Plan sponsor is Scios Inc.  which bears the
costs of all the benefits under the Plan. The Employer  Identification number of
Scios is  95-3701481;  and the Plan number  assigned  by Scios is 502.  The Plan
Administrator's  name,  business address,  and telephone number are: Scios Inc.,
820 West Maude Avenue,  Sunnyvale,  California 94086,  (408) 616-8200.  The Plan
Administrator is the agent for service of legal process.

         Statement of ERISA Rights.  A  participant  in this Plan is entitled to
certain  rights and  protections  under a federal  law known as  "ERISA."  ERISA
provides  that all Plan  participants  shall be  entitled  to  examine,  without
charge, at the Plan  Administrator's  office,  all Plan documents and the Plan's
annual report.  Copies of these documents and other Plan information may also be
obtained upon written request to the Plan Administrator. A reasonable charge may
be made for copies.

         In addition to creating rights for the Plan participants, ERISA imposes
duties upon the people who are  responsible  for the operation of this Plan. The
people who operate this Plan,  called  "fiduciaries" of the Plan, have a duty to
do so prudently and in the interest of you and other Plan participants.  No one,
including  your  employer,  or any  other  person,  may  fire  you or  otherwise
discriminate  against you in any way to prevent you from  obtaining  benefits or
exercising your rights under ERISA. If your claim benefits is denied in whole or
in part,  you must receive a written  explanation of the reason for this denial.
You have the right to have the Plan  Administrator  review and  reconsider  your
claim, as described elsewhere in this summary plan description.

<PAGE>

         Under ERISA,  there are steps you can take to enforce the above rights,
For  instance,  if you request  materials  from the Plan and do not receive them
within 30 days, you may file suit in a federal court.  In such a case, the court
may require the Plan  Administrator  to provide the  materials and pay you up to
$100 a day until you receive the  materials,  unless the materials were not sent
because of reasons beyond the control of the Plan  Administrator.  If you have a
claim for benefits which is denied or ignored, in whole or in part, you may file
a suit  in a state  or  federal  court.  If you are  discriminated  against  for
asserting  your rights,  you may seek  assistance  from the U.S.  Department  of
Labor, or you may file suit in a federal court. The court will decide who should
pay court costs and legal fees.  If you are  successful  the court may order the
person  you have sued to pay these  costs and fees.  If you lose,  the court may
order you to pay these costs and fees,  for  example,  if it finds your claim is
frivolous.

         If you have any questions  about your Plan, you should contact the Plan
Administrator.  If you have any  questions  about this  statement  or about your
rights  under  ERISA,  you should  contact the  nearest  Area Office of the U.S.
Labor-Management Services Administration, Department of Labor.

         Governing  Law.  The  Plan  shall  be  interpreted,  administered,  and
enforced in  accordance  with ERISA and the rights of the  participants  and all
other person shall be determined in accordance with that law. To the extent that
state  law  is  applicable,  however,  the  substantive  laws  of the  state  of
California shall govern.

<PAGE>

                                  Attachment C

                          Provisions of General Release

         The release  will provide that your  acceptance  of severance  benefits
under the Plan will constitute a full and complete release by you of any and all
claims you may have  against  the  Company,  any of its past,  present or future
stockholders or any of their  respective  officers,  directors,  employees,  and
affiliates (past, present or future),  including, but not limited to, claims you
might have relating to your employment  and/or  cessation of employment with the
Company, including without limitation,  tort, contract and common law claims and
claims under Title VII of the Civil Rights Act of 1964,  the Age  Discrimination
in Employment Act of 1967, the Americans with  Disabilities  Act of 1990, or any
other similar  federal,  state or local statute,  rule or  regulation;  provided
that,  there  shall be  excluded  from the  scope of such  general  release  the
following:

                    o    claims  that  you may  have  against  the  Company  for
                         reimbursement  of  reasonable  and  necessary  business
                         expenses  incurred  by you  during  the  course of your
                         employment;

                    o    claims  that may be made by you for  payment of accrued
                         salary,  stock  options,   pension  benefits  or  other
                         continuing benefits as specifically provided for in the
                         Plan.

        The release will also have the provisions set forth in the memorandum.



                                                                    EXHIBIT 99.4

[Scios Logo]

To:      Scios Employees in Levels 18-20
From:    The Board of Directors
Re:      Scios Inc. Change of Control Severance Plan:  Levels 18-20
Date:    January 11, 2000

         The Board of  Directors  of the  Company  has  approved  the Scios Inc.
Change of Control  Severance  Plan:  Levels  18-20 (the "Plan")  which  provides
certain severance benefits for you, effective immediately, in the event that you
lose your job as a result of a change of control of Scios  Inc.  that  occurs at
any time on or after  January 11, 2000 and on or prior to December 31, 2001 (the
"Plan Term").

         All words  that  appear in italics in this  memorandum  are  defined in
Attachment A to this memorandum.

         Severance Benefits. If your employment is involuntarily  terminated for
any  reason  (other  than for  Cause,  your  death or your  Disability),  or you
voluntarily  terminate your employment for Good Reason,  in either case,  within
365 days on or after a Change of Control  occurring  during  the Plan Term,  you
will be entitled to receive the following payments and benefits:

                  (a) A lump sum  severance  payment  equal to three  times your
weekly  Compensation  for each full year you have been  employed by the Company;
provided  that your  minimum  severance  payment  will be equal to 12 times your
weekly Compensation. The severance amount to which you are entitled will be paid
to you in cash  within  15  calendar  days  after the date  your  employment  is
terminated and your general release described below becomes irrevocable.

                  (b) Payment by the Company for up to three months of COBRA for
continuation of health care benefits  (including any medical,  dental and vision
coverage)  for you and your  dependents  under the same  plans or  substantially
similar plan(s) established by the Company or its subsidiaries thereafter.  Such
health  coverage  will be paid for by the Company  only to the same extent as if
you were still employed by the Company, and you will be required to pay for such
health  benefits  to the same  extent that you would be required to do so if you
were still  employed by the Company.  These  benefits will terminate on the date
you become  covered  under any other  group  health plan not  maintained  by the
Company or its  subsidiaries  which provides equal or greater benefits than such
plan and which does not  exclude  any  pre-existing  condition  that you or your
dependents may have at that time.

<PAGE>

                  (c)      Provision of outplacement services by an organization
selected by the Company up to a maximum cost of $5,000.

         Withholding  of  Taxes.  The  Company  will  withhold  from  any of the
foregoing  amounts  payable  to you all  federal,  state,  city or  other  taxes
required by applicable law to be withheld by the Company.

         Other Benefits.  The severance  benefits described here are intended to
be provided in lieu of and to replace  any  similar or  duplicative  benefits to
which you may be entitled  from the Company or its  subsidiaries  in  connection
with the  termination  of your  employment  after a Change of Control  occurring
during  the Plan Term  under  any other  severance  plan,  agreement,  policy or
program.  This Plan does not  obligate  the  Company to provide you or any other
employees  with any  severance  benefits  if your  employment  terminates  under
circumstances not covered by this Plan. However,  this is not intended to reduce
any amounts  otherwise  payable,  or in any way  diminish  your rights under any
incentive,  retirement,  pension, profit sharing, stock purchase or benefit plan
or other  arrangement  not related to  severance  following a Change of Control.
These  severance  benefits  will not affect  your  rights to any stock  options,
restricted stock or other equity interests  granted by the Company now or in the
future.

         No Employment.  This Plan is not an employment agreement and nothing in
this Plan requires you to stay in the  employment  of the Company,  requires the
Company to retain you in your present position or any other position, or changes
the status of your employment at will.

         No Setoff.  The Company's  obligation to make severance payments to you
under this Plan and otherwise to perform its obligations will not be affected by
any  circumstances,  including,  but not limited  to, any setoff,  counterclaim,
recoupment,  defense or other right which the  Company or its  subsidiaries  may
have against you or others.

         Claims and Disputes.  You will have the right (but not the  obligation)
to  elect  (in  lieu of  litigation)  to have any  dispute  arising  under or in
connection  with this Plan which is not  otherwise  resolved  through the claims
procedure  described in  Attachment B settled by  arbitration,  conducted by one
arbitrator  sitting in a location  selected by you within  fifty (50) miles from
the  location of your job with the Company in  accordance  with the rules of the
American Arbitration Association then in effect. Judgement may be entered on the
award of the  arbitrator  in any  court  having  jurisdiction.  All  arbitration
expenses,  including all attorney  fees incurred in good faith,  will be paid by
the  Company.  You shall be  conclusively  presumed  to have acted in good faith
unless and until the arbitrator makes a final determination to the contrary.

         Legal  Fees.  If the  Company  refuses or fails to provide you with any
severance  benefits under this Plan or contests the validity of the Plan or your
rights to  benefits,  the Company  will pay, as they become due, all legal fees,
costs of litigation and other expenses  incurred in good faith by you. You shall
be  conclusively  presumed  to have acted in good faith  unless a court  makes a
final determination not otherwise subject to appeal to the contrary.

         Notice of Termination.  Following a Change of Control  occurring during
the Plan Term, any purported  termination  of your  employment by the Company or
its subsidiaries shall be

<PAGE>

communicated by written notice which will indicate, if it is based on Cause,
the specific reasons relied upon and which sets forth in reasonable detail the
facts and  circumstances  claimed to provide a basis for termination for Cause.

         Term.  This  Plan will  expire on the last day of the Plan Term  (i.e.,
December 31,  2001) if a Change of Control has not  occurred by that date.  If a
Change of Control  occurs on or before  that  date,  the Plan will  continue  in
effect and not expire until 366 calendar days from and including the date of the
Change of  Control,  at which  time the Plan will  expire  except if you  become
entitled to the severance  benefits  described  above prior to such time. If you
become entitled to severance  benefits,  the Plan will continue until you or any
other person  covered  have  received in full all  severance  payments and other
benefits due.

         Amendment.  This Plan may not be terminated or amended in any manner
which may adversely affect your rights under it, unless you expressly agree.

         Successor.  The Company will require any successor to its business or
substantially all of its assets to assume and agree to perform the Company's
obligations to you under this Plan.

         ERISA. This Plan is subject to the Employee  Retirement Income Security
Act of 1974, as amended ("ERISA").  See Attachment B, which is part of the Plan,
for a statement  of certain  Plan  information  and the rules  applicable  under
ERISA.

         General Release.  A condition to your receipt of any severance payments
under this Plan will be your  execution and delivery (and the  expiration of any
applicable  revocability  period given by law) of a general release as described
in Attachment C in a form reasonably  satisfactory  to the Company.  The release
will also have (a) appropriate  provisions  necessary to insure that it is valid
and  enforceable  under  applicable  laws,  including the Older Workers  Benefit
Protection  Act and (b) a waiver of  California  Civil Code  Section 1542 (which
provides that unless you  specifically  agree to release  claims you do not know
about,  they are not  released  by a general  release).  Your  payments  will be
considered independent consideration made in exchange for your release.

         We believe this Plan will help satisfy some of the concern you may have
in this uncertain  period.  If you have any questions  about your benefits under
this Plan, please call Lauretta C. Cesario at (408) 616-8306.

                                                     Sincerely,

                                                     /s/

                                                     Richard B. Brewer
                                                     President and CEO

<PAGE>

                                    Exhibit A

                                   Definitions

         Whenever used in this memorandum,  the following  italicized words have
the meanings set forth below:

"Cause" means a termination  for any of the following  reasons:  (i) engaging in
intentional  misconduct  which  would  tend to  discredit  the  Company  or your
position;  (ii) being  convicted of a felony;  (iii)  committing an act of fraud
against  the  Company  or the  willful  material  misappropriation  of  property
belonging to the Company; (iv) materially breaching any proprietary  information
agreement between you and the Company or (v) willfully  disregarding your duties
despite adequate warnings from the Company.

"Change of Control" of the Company means and includes any of the following:

     o    "Any person" or "group" (as those terms are defined in the  Securities
          Exchange Act of 1934,  as amended (the  "Exchange  Act") and the rules
          and regulations  promulgated thereunder) is or becomes, on or prior to
          December 31,  2001,  the  "beneficial  owner (as defined in Rule 13d-3
          under the Exchange Act)", directly or indirectly, of securities of the
          Company  representing  fifty percent (50%) or more of the voting power
          of then outstanding securities of the Company.

     o    Any person or group is or becomes,  on or prior to December  31, 2001,
          the beneficial  owner,  directly or  indirectly,  of securities of the
          Company  representing twenty percent (20%) or more of the voting power
          of the  then  outstanding  securities  of  the  Company,  unless  such
          acquisition  was  approved  in  advance  by  the  Company's  Board  of
          Directors.

     o    The  individuals  who,  as of the  date  hereof,  are  members  of the
          Company's Board of Directors (the "Existing Directors"),  cease, on or
          prior to December 31, 2001,  for any reason,  to constitute  more than
          fifty  percent  (50%) of the  number of  authorized  directors  of the
          Company  as  determined  in the  manner  prescribed  in the  Company's
          Certificate of Incorporation and Bylaws;  provided,  however,  that if
          the appointment,  or the election,  or nomination for election, by the
          Company's  stockholders of any new director, was approved by a vote of
          at least  fifty  percent  (50%) of the  Existing  Directors,  such new
          director shall be considered an Existing  Director;  provided further,
          however,  that no individual shall be considered an Existing  Director
          if such individual  initially  assumed office as a result of either an
          actual or threatened election contest (as described in Rule 14a-11 or,
          effective  January 24,  2000,  Rule  14a-12(c)  promulgated  under the
          Exchange Act) or other actual or threatened solicitation of proxies by
          or on behalf of anyone  other  than the Board of  Directors  (a "Proxy
          Contest"),  including by reason of any agreement  intended to avoid or
          settle any election contest or Proxy Contest.

<PAGE>

     o    The  consummation,  on or prior to  December  31,  2001,  of a merger,
          consolidation  or  reorganization  to which  the  Company  is a party,
          whether  or not the  Company  is the  person  surviving  or  resulting
          therefrom, in one transaction or a series of related transactions,  to
          any person(s) other than a subsidiary, provided, however, that no such
          transaction  shall  constitute a "Change of Control" under this clause
          if the persons who were the  stockholders  of the Company  immediately
          before the consummation of such transaction are the beneficial owners,
          immediately  following the consummation of such transaction,  of fifty
          percent  (50%)  or more  of the  combined  voting  power  of the  then
          outstanding  voting  securities  of the person  surviving or resulting
          from any merger, consolidation or reorganization.

     o    The  consummation,  on or  prior  to  December  31,  2001,  of a sale,
          assignment,  lease,  conveyance or other disposition of 50% or more of
          the assets or assets  representing 50% or more of the earning power of
          the  Company,  in one  or a  series  of  related  transactions  to any
          Person(s) other than a Subsidiary.

     o    A complete liquidation of the Company.

"COBRA" means the Consolidated Omnibus Budget Reconciliation Act of 1985.

"Compensation"  means your base salary per week at the time your  employment  is
terminated  attributable  to your  employment with the Company and/or any of its
Subsidiaries  (including,  but not  limited  to, any  amounts  excluded  at your
election  from your gross  income for federal  income tax  purposes  pursuant to
Section 125 or Section 401(k) of the Internal  Revenue Code of 1986, as amended,
or deferred pursuant to any Company or Subsidiary plan or program).

"Disability"  means a physical or mental infirmity which  substantially  impairs
your  ability  to  perform  your  material  duties  for a period of at least one
hundred  eighty  (180)  consecutive  calendar  days  and,  as a  result  of such
Disability,  you have not returned to your full-time regular employment prior to
termination.

 "Good Reason"  means either of the  following:  (i) any material  breach by the
Company of any  provision of this Plan;  or (ii) a reduction in the amount equal
to the sum of (a) your total annual cash salary and (b) your bonus  opportunity,
if any,  in each  case as in  effect  on the date  hereof  or as the same may be
increased from time to time.

<PAGE>

                                  Attachment B

                                ERISA Supplement

         Rules applicable under the Employee Retirement Security Act (ERISA) to
the Scios Inc.  Change of Control Severance Plan: Levels 18-20 (the "Plan"):

         Claims  Procedure.  All claims and appeals of denied  claims under this
Plan  shall be  processed  by the Plan  Administrator.  A claim must be filed in
writing  within  90 days of the time it  arises.  The Plan  Administrator  shall
respond  to the  claim  within 90 days  unless a longer  time  period  (up to an
additional  90 days) is  required  and  proper  notice is  given.  If a claim is
denied, a written denial shall be issued which contains the information required
by the Employee  Retirement  Income  Security Act of 1974  (ERISA).  Review of a
denied claim may be requested by written  application to the Plan  Administrator
within 60 days of the denial. The Plan  Administrator  shall complete the review
within 60 days of the request  unless a longer  period (up to an  additional  60
days) is required and proper notice is given. The decision on appeal shall be in
writing  and  shall  contain  the  information   required  by  ERISA.  The  Plan
Administrator  may adopt rules  which  specify  the  procedures  for a claim and
review in more detail and such procedures shall be binding to the same extent as
if originally included in this Plan.

        Information  provided  under ERISA.  This Plan is an unfunded  severance
plan, maintained on a calendar year basis. In addition to constituting the Plan,
this  memorandum,  and  its  attachments,  also  constitutes  the  summary  plan
description  required by ERISA.  The Plan sponsor is Scios Inc.  which bears the
costs of all the benefits under the Plan. The Employer  Identification number of
Scios is  95-3701481;  and the Plan number  assigned  by Scios is 503.  The Plan
Administrator's  name,  business address,  and telephone number are: Scios Inc.,
820 West Maude Avenue,  Sunnyvale,  California 94086,  (408) 616-8200.  The Plan
Administrator is the agent for service of legal process.

         Statement of ERISA Rights.  A  participant  in this Plan is entitled to
certain  rights and  protections  under a federal  law known as  "ERISA."  ERISA
provides  that all Plan  participants  shall be  entitled  to  examine,  without
charge, at the Plan  Administrator's  office,  all Plan documents and the Plan's
annual report.  Copies of these documents and other Plan information may also be
obtained upon written request to the Plan Administrator. A reasonable charge may
be made for copies.

         In addition to creating rights for the Plan participants, ERISA imposes
duties upon the people who are  responsible  for the operation of this Plan. The
people who operate this Plan,  called  "fiduciaries" of the Plan, have a duty to
do so prudently and in the interest of you and other Plan participants.  No one,
including  your  employer,  or any  other  person,  may  fire  you or  otherwise
discriminate  against you in any way to prevent you from  obtaining  benefits or
exercising your rights under ERISA. If your claim benefits is denied in whole or
in part,  you must receive a written  explanation of the reason for this denial.
You have the right to have the Plan  Administrator  review and  reconsider  your
claim, as described elsewhere in this summary plan description.

<PAGE>

         Under ERISA,  there are steps you can take to enforce the above rights,
For  instance,  if you request  materials  from the Plan and do not receive them
within 30 days, you may file suit in a federal court.  In such a case, the court
may require the Plan  Administrator  to provide the  materials and pay you up to
$100 a day until you receive the  materials,  unless the materials were not sent
because of reasons beyond the control of the Plan  Administrator.  If you have a
claim for benefits which is denied or ignored, in whole or in part, you may file
a suit  in a state  or  federal  court.  If you are  discriminated  against  for
asserting  your rights,  you may seek  assistance  from the U.S.  Department  of
Labor, or you may file suit in a federal court. The court will decide who should
pay court costs and legal fees.  If you are  successful  the court may order the
person  you have sued to pay these  costs and fees.  If you lose,  the court may
order you to pay these costs and fees,  for  example,  if it finds your claim is
frivolous.

         If you have any questions  about your Plan, you should contact the Plan
Administrator.  If you have any  questions  about this  statement  or about your
rights  under  ERISA,  you should  contact the  nearest  Area Office of the U.S.
Labor-Management Services Administration, Department of Labor.

         Governing  Law.  The  Plan  shall  be  interpreted,  administered,  and
enforced in  accordance  with ERISA and the rights of the  participants  and all
other person shall be determined in accordance with that law. To the extent that
state  law  is  applicable,  however,  the  substantive  laws  of the  state  of
California shall govern.

<PAGE>

                                  Attachment C

                          Provisions of General Release

         The release  will provide that your  acceptance  of severance  benefits
under the Plan will constitute a full and complete release by you of any and all
claims you may have  against  the  Company,  any of its past,  present or future
stockholders or any of their  respective  officers,  directors,  employees,  and
affiliates (past, present or future),  including, but not limited to, claims you
might have relating to your employment  and/or  cessation of employment with the
Company, including without limitation,  tort, contract and common law claims and
claims under Title VII of the Civil Rights Act of 1964,  the Age  Discrimination
in Employment Act of 1967, the Americans with  Disabilities  Act of 1990, or any
other similar  federal,  state or local statute,  rule or  regulation;  provided
that,  there  shall be  excluded  from the  scope of such  general  release  the
following:

                    o    claims  that  you may  have  against  the  Company  for
                         reimbursement  of  reasonable  and  necessary  business
                         expenses  incurred  by you  during  the  course of your
                         employment;

                    o    claims  that may be made by you for  payment of accrued
                         salary,  stock  options,   pension  benefits  or  other
                         continuing benefits as specifically provided for in the
                         Plan.

        The release will also have the provisions set forth in the memorandum.



                                                                    EXHIBIT 99.5

[Scios Logo]

To:      Scios Employees in Levels 21-24
From:    The Board of Directors
Re:      Scios Inc. Change of Control Severance Plan:  Levels 21-24
Date:    January 11, 2000

         The Board of  Directors  of the  Company  has  approved  the Scios Inc.
Change of Control  Severance  Plan:  Levels  21-24 (the "Plan")  which  provides
certain severance benefits for you, effective immediately, in the event that you
lose your job as a result of a change of control of Scios  Inc.  that  occurs at
any time on or after  January 11, 2000 and on or prior to December 31, 2001 (the
"Plan Term").

         All words  that  appear in italics in this  memorandum  are  defined in
Attachment A to this memorandum.

         Severance Benefits. If your employment is involuntarily  terminated for
any  reason  (other  than for  Cause,  your  death or your  Disability),  or you
voluntarily  terminate your employment for Good Reason,  in either case,  within
365 days on or after a Change of Control  occurring  during  the Plan Term,  you
will be entitled to receive the following payments and benefits:

                  (a) A lump sum  severance  payment  equal to four  times  your
weekly  Compensation  for each full year you have been  employed by the Company;
provided  that your  minimum  severance  payment  will be equal to 16 times your
weekly Compensation. The severance amount to which you are entitled will be paid
to you in cash  within  15  calendar  days  after the date  your  employment  is
terminated and your general release described below becomes irrevocable.

                  (b) Payment by the Company for up to three months of COBRA for
continuation of health care benefits  (including any medical,  dental and vision
coverage)  for you and your  dependents  under the same  plans or  substantially
similar plan(s) established by the Company or its subsidiaries thereafter.  Such
health  coverage  will be paid for by the Company  only to the same extent as if
you were still employed by the Company, and you will be required to pay for such
health  benefits  to the same  extent that you would be required to do so if you
were still  employed by the Company.  These  benefits will terminate on the date
you become  covered  under any other  group  health plan not  maintained  by the
Company or its  subsidiaries  which provides equal or greater benefits than such
plan and which does not  exclude  any  pre-existing  condition  that you or your
dependents may have at that time.

                  (c)      Provision of outplacement services by an organization
selected by the Company up to a maximum cost of $6,000.

<PAGE>

         Withholding  of  Taxes.  The  Company  will  withhold  from  any of the
foregoing  amounts  payable  to you all  federal,  state,  city or  other  taxes
required by applicable law to be withheld by the Company.

         Other Benefits.  The severance  benefits described here are intended to
be provided in lieu of and to replace  any  similar or  duplicative  benefits to
which you may be entitled  from the Company or its  subsidiaries  in  connection
with the  termination  of your  employment  after a Change of Control  occurring
during  the Plan Term  under  any other  severance  plan,  agreement,  policy or
program.  This Plan does not  obligate  the  Company to provide you or any other
employees  with any  severance  benefits  if your  employment  terminates  under
circumstances not covered by this Plan. However,  this is not intended to reduce
any amounts  otherwise  payable,  or in any way  diminish  your rights under any
incentive,  retirement,  pension, profit sharing, stock purchase or benefit plan
or other  arrangement  not related to  severance  following a Change of Control.
These  severance  benefits  will not affect  your  rights to any stock  options,
restricted stock or other equity interests  granted by the Company now or in the
future.

         No Employment.  This Plan is not an employment agreement and nothing in
this Plan requires you to stay in the  employment  of the Company,  requires the
Company to retain you in your present position or any other position, or changes
the status of your employment at will.

         No Setoff.  The Company's  obligation to make severance payments to you
under this Plan and otherwise to perform its obligations will not be affected by
any  circumstances,  including,  but not limited  to, any setoff,  counterclaim,
recoupment,  defense or other right which the  Company or its  subsidiaries  may
have against you or others.

         Claims and Disputes.  You will have the right (but not the  obligation)
to  elect  (in  lieu of  litigation)  to have any  dispute  arising  under or in
connection  with this Plan which is not  otherwise  resolved  through the claims
procedure  described in  Attachment B settled by  arbitration,  conducted by one
arbitrator  sitting in a location  selected by you within  fifty (50) miles from
the  location of your job with the Company in  accordance  with the rules of the
American Arbitration Association then in effect. Judgement may be entered on the
award of the  arbitrator  in any  court  having  jurisdiction.  All  arbitration
expenses,  including all attorney  fees incurred in good faith,  will be paid by
the  Company.  You shall be  conclusively  presumed  to have acted in good faith
unless and until the arbitrator makes a final determination to the contrary.

         Legal  Fees.  If the  Company  refuses or fails to provide you with any
severance  benefits under this Plan or contests the validity of the Plan or your
rights to  benefits,  the Company  will pay, as they become due, all legal fees,
costs of litigation and other expenses  incurred in good faith by you. You shall
be  conclusively  presumed  to have acted in good faith  unless a court  makes a
final determination not otherwise subject to appeal to the contrary.

         Notice of Termination.  Following a Change of Control  occurring during
the Plan Term, any purported  termination  of your  employment by the Company or
its subsidiaries shall be communicated by written notice which will indicate, if
it is based on Cause,  the specific  reasons relied upon and which sets forth in
reasonable  detail  the facts and  circumstances  claimed to provide a basis for
termination for Cause.

<PAGE>

         Term.  This  Plan will  expire on the last day of the Plan Term  (i.e.,
December 31,  2001) if a Change of Control has not  occurred by that date.  If a
Change of Control  occurs on or before  that  date,  the Plan will  continue  in
effect and not expire until 366 calendar days from and including the date of the
Change of  Control,  at which  time the Plan will  expire  except if you  become
entitled to the severance  benefits  described  above prior to such time. If you
become entitled to severance  benefits,  the Plan will continue until you or any
other person  covered  have  received in full all  severance  payments and other
benefits due.

         Amendment.  This Plan may not be terminated or amended in any manner
which may adversely affect your rights under it, unless you expressly agree.

         Successor.  The Company will require any successor to its business or
substantially all of its assets to assume and agree to perform the Company's
obligations to you under this Plan.

         ERISA. This Plan is subject to the Employee  Retirement Income Security
Act of 1974, as amended ("ERISA").  See Attachment B, which is part of the Plan,
for a statement  of certain  Plan  information  and the rules  applicable  under
ERISA.

         General Release.  A condition to your receipt of any severance payments
under this Plan will be your  execution and delivery (and the  expiration of any
applicable  revocability  period given by law) of a general release as described
in Attachment C in a form reasonably  satisfactory  to the Company.  The release
will also have (a) appropriate  provisions  necessary to insure that it is valid
and  enforceable  under  applicable  laws,  including the Older Workers  Benefit
Protection  Act and (b) a waiver of  California  Civil Code  Section 1542 (which
provides that unless you  specifically  agree to release  claims you do not know
about,  they are not  released  by a general  release).  Your  payments  will be
considered independent consideration made in exchange for your release.

         We believe this Plan will help satisfy some of the concern you may have
in this uncertain  period.  If you have any questions  about your benefits under
this Plan, please call Lauretta C. Cesario at (408) 616-8306.

                                                     Sincerely,

                                                     /s/

                                                     Richard B. Brewer
                                                     President and CEO

<PAGE>

                                    Exhibit A

                                   Definitions

         Whenever used in this memorandum,  the following  italicized words have
the meanings set forth below:

"Cause" means a termination  for any of the following  reasons:  (i) engaging in
intentional  misconduct  which  would  tend to  discredit  the  Company  or your
position;  (ii) being  convicted of a felony;  (iii)  committing an act of fraud
against  the  Company  or the  willful  material  misappropriation  of  property
belonging to the Company; (iv) materially breaching any proprietary  information
agreement between you and the Company or (v) willfully  disregarding your duties
despite adequate warnings from the Company.

"Change of Control" of the Company means and includes any of the following:

                    o    "Any  person" or "group" (as those terms are defined in
                         the  Securities  Exchange Act of 1934,  as amended (the
                         "Exchange   Act")  and  the   rules   and   regulations
                         promulgated  thereunder) is or becomes,  on or prior to
                         December 31, 2001, the "beneficial owner (as defined in
                         Rule  13d-3  under  the  Exchange  Act)",  directly  or
                         indirectly,  of securities of the Company  representing
                         fifty percent (50%) or more of the voting power of then
                         outstanding securities of the Company.

                    o    Any  person  or  group  is or  becomes,  on or prior to
                         December 31, 2001,  the beneficial  owner,  directly or
                         indirectly,  of securities of the Company  representing
                         twenty percent (20%) or more of the voting power of the
                         then outstanding securities of the Company, unless such
                         acquisition  was  approved in advance by the  Company's
                         Board of Directors.

                    o    The individuals who, as of the date hereof, are members
                         of the  Company's  Board of  Directors  (the  "Existing
                         Directors"),  cease,  on or prior to December 31, 2001,
                         for any reason,  to constitute  more than fifty percent
                         (50%) of the  number  of  authorized  directors  of the
                         Company as determined  in the manner  prescribed in the
                         Company's  Certificate  of  Incorporation  and  Bylaws;
                         provided,  however,  that  if the  appointment,  or the
                         election,  or nomination for election, by the Company's
                         stockholders  of any new  director,  was  approved by a
                         vote of at least fifty  percent  (50%) of the  Existing
                         Directors,  such new director  shall be  considered  an
                         Existing Director;  provided further,  however, that no
                         individual shall be considered an Existing  Director if
                         such individual initially assumed office as a result of
                         either an actual or  threatened  election  contest  (as
                         described  in Rule  14a-11 or,  effective  January  24,
                         2000,  Rule  14a-12(c)  promulgated  under the Exchange
                         Act) or other  actual  or  threatened  solicitation  of
                         proxies by or on behalf of anyone  other than the Board
                         of Directors (a "Proxy  Contest"),  including by reason
                         of any  agreement  intended  to  avoid  or  settle  any
                         election contest or Proxy Contest.

<PAGE>

                    o    The consummation,  on or prior to December 31, 2001, of
                         a merger,  consolidation or reorganization to which the
                         Company is a party,  whether or not the  Company is the
                         person  surviving  or  resulting   therefrom,   in  one
                         transaction or a series of related transactions, to any
                         person(s) other than a subsidiary,  provided,  however,
                         that no such transaction  shall constitute a "Change of
                         Control"  under this clause if the persons who were the
                         stockholders  of the  Company  immediately  before  the
                         consummation  of such  transaction  are the  beneficial
                         owners,  immediately following the consummation of such
                         transaction,  of  fifty  percent  (50%)  or more of the
                         combined  voting power of the then  outstanding  voting
                         securities  of the person  surviving or resulting  from
                         any merger, consolidation or reorganization.

                    o    The consummation,  on or prior to December 31, 2001, of
                         a  sale,   assignment,   lease,   conveyance  or  other
                         disposition  of 50% or more  of the  assets  or  assets
                         representing  50% or more of the  earning  power of the
                         Company, in one or a series of related  transactions to
                         any Person(s) other than a Subsidiary.

                    o    A complete liquidation of the Company.

"COBRA" means the Consolidated Omnibus Budget Reconciliation Act of 1985.

"Compensation"  means your base salary per week at the time your  employment  is
terminated  attributable  to your  employment with the Company and/or any of its
Subsidiaries  (including,  but not  limited  to, any  amounts  excluded  at your
election  from your gross  income for federal  income tax  purposes  pursuant to
Section 125 or Section 401(k) of the Internal  Revenue Code of 1986, as amended,
or deferred pursuant to any Company or Subsidiary plan or program).

"Disability"  means a physical or mental infirmity which  substantially  impairs
your  ability  to  perform  your  material  duties  for a period of at least one
hundred  eighty  (180)  consecutive  calendar  days  and,  as a  result  of such
Disability,  you have not returned to your full-time regular employment prior to
termination.

 "Good Reason"  means either of the  following:  (i) any material  breach by the
Company of any  provision of this Plan;  or (ii) a reduction in the amount equal
to the sum of (a) your total annual cash salary and (b) your bonus  opportunity,
if any,  in each  case as in  effect  on the date  hereof  or as the same may be
increased from time to time.

<PAGE>

                                  Attachment B

                                ERISA Supplement

         Rules applicable under the Employee Retirement Security Act (ERISA) to
the Scios Inc.  Change of Control Severance Plan: Levels 21-24 (the "Plan"):

         Claims  Procedure.  All claims and appeals of denied  claims under this
Plan  shall be  processed  by the Plan  Administrator.  A claim must be filed in
writing  within  90 days of the time it  arises.  The Plan  Administrator  shall
respond  to the  claim  within 90 days  unless a longer  time  period  (up to an
additional  90 days) is  required  and  proper  notice is  given.  If a claim is
denied, a written denial shall be issued which contains the information required
by the Employee  Retirement  Income  Security Act of 1974  (ERISA).  Review of a
denied claim may be requested by written  application to the Plan  Administrator
within 60 days of the denial. The Plan  Administrator  shall complete the review
within 60 days of the request  unless a longer  period (up to an  additional  60
days) is required and proper notice is given. The decision on appeal shall be in
writing  and  shall  contain  the  information   required  by  ERISA.  The  Plan
Administrator  may adopt rules  which  specify  the  procedures  for a claim and
review in more detail and such procedures shall be binding to the same extent as
if originally included in this Plan.

        Information  provided  under ERISA.  This Plan is an unfunded  severance
plan, maintained on a calendar year basis. In addition to constituting the Plan,
this  memorandum,  and  its  attachments,  also  constitutes  the  summary  plan
description  required by ERISA.  The Plan sponsor is Scios Inc.  which bears the
costs of all the benefits under the Plan. The Employer  Identification number of
Scios is  95-3701481;  and the Plan number  assigned  by Scios is 504.  The Plan
Administrator's  name,  business address,  and telephone number are: Scios Inc.,
820 West Maude Avenue,  Sunnyvale,  California 94086,  (408) 616-8200.  The Plan
Administrator is the agent for service of legal process.

         Statement of ERISA Rights.  A  participant  in this Plan is entitled to
certain  rights and  protections  under a federal  law known as  "ERISA."  ERISA
provides  that all Plan  participants  shall be  entitled  to  examine,  without
charge, at the Plan  Administrator's  office,  all Plan documents and the Plan's
annual report.  Copies of these documents and other Plan information may also be
obtained upon written request to the Plan Administrator. A reasonable charge may
be made for copies.

         In addition to creating rights for the Plan participants, ERISA imposes
duties upon the people who are  responsible  for the operation of this Plan. The
people who operate this Plan,  called  "fiduciaries" of the Plan, have a duty to
do so prudently and in the interest of you and other Plan participants.  No one,
including  your  employer,  or any  other  person,  may  fire  you or  otherwise
discriminate  against you in any way to prevent you from  obtaining  benefits or
exercising your rights under ERISA. If your claim benefits is denied in whole or
in part,  you must receive a written  explanation of the reason for this denial.
You have the right to have the Plan  Administrator  review and  reconsider  your
claim, as described elsewhere in this summary plan description.

<PAGE>

         Under ERISA,  there are steps you can take to enforce the above rights,
For  instance,  if you request  materials  from the Plan and do not receive them
within 30 days, you may file suit in a federal court.  In such a case, the court
may require the Plan  Administrator  to provide the  materials and pay you up to
$100 a day until you receive the  materials,  unless the materials were not sent
because of reasons beyond the control of the Plan  Administrator.  If you have a
claim for benefits which is denied or ignored, in whole or in part, you may file
a suit  in a state  or  federal  court.  If you are  discriminated  against  for
asserting  your rights,  you may seek  assistance  from the U.S.  Department  of
Labor, or you may file suit in a federal court. The court will decide who should
pay court costs and legal fees.  If you are  successful  the court may order the
person  you have sued to pay these  costs and fees.  If you lose,  the court may
order you to pay these costs and fees,  for  example,  if it finds your claim is
frivolous.

         If you have any questions  about your Plan, you should contact the Plan
Administrator.  If you have any  questions  about this  statement  or about your
rights  under  ERISA,  you should  contact the  nearest  Area Office of the U.S.
Labor-Management Services Administration, Department of Labor.

         Governing  Law.  The  Plan  shall  be  interpreted,  administered,  and
enforced in  accordance  with ERISA and the rights of the  participants  and all
other person shall be determined in accordance with that law. To the extent that
state  law  is  applicable,  however,  the  substantive  laws  of the  state  of
California shall govern.

<PAGE>

                                  Attachment C

                          Provisions of General Release

         The release  will provide that your  acceptance  of severance  benefits
under the Plan will constitute a full and complete release by you of any and all
claims you may have  against  the  Company,  any of its past,  present or future
stockholders or any of their  respective  officers,  directors,  employees,  and
affiliates (past, present or future),  including, but not limited to, claims you
might have relating to your employment  and/or  cessation of employment with the
Company, including without limitation,  tort, contract and common law claims and
claims under Title VII of the Civil Rights Act of 1964,  the Age  Discrimination
in Employment Act of 1967, the Americans with  Disabilities  Act of 1990, or any
other similar  federal,  state or local statute,  rule or  regulation;  provided
that,  there  shall be  excluded  from the  scope of such  general  release  the
following:

                    o    claims  that  you may  have  against  the  Company  for
                         reimbursement  of  reasonable  and  necessary  business
                         expenses  incurred  by you  during  the  course of your
                         employment;

                    o    claims  that may be made by you for  payment of accrued
                         salary,  stock  options,   pension  benefits  or  other
                         continuing benefits as specifically provided for in the
                         Plan.

        The release will also have the provisions set forth in the memorandum.




                                                                    EXHIBIT 99.6


                                   SCIOS INC.
                              820 West Maude Avenue
                           Sunnyvale, California 94086

January 11, 2000

[Name]
[Title]
Scios Inc.
820 West Maude Avenue
Sunnyvale, California 94086

Dear [Name]:

         The Board of Directors of Scios Inc.  (the  "Company")  has  determined
that it is in the best  interests of the Company and its  stockholders  to offer
you the following  agreement (the  "Agreement")  which provides you with certain
severance  payments  and  benefits  if your  employment  terminates  following a
"Change of Control" (as defined below).

                                    ARTICLE I
                                   DEFINITIONS

1.1      Definitions

         Whenever used in this Agreement,  the following capitalized terms shall
have the meanings set forth in this  Section,  certain other  capitalized  terms
being defined elsewhere in this Agreement:

        (a)     "Beneficial  Owner"  shall have the  meaning  ascribed to such
term in Rule 13d-3 promulgated under the Exchange Act.

        (b)     "Board of Directors" means the Board of Directors of the
Company.

        (c)     "Cause" means a termination for any of the following  reasons:
(i) engaging in  intentional  misconduct  which would tend to  discredit
the Company or your position as an officer of the Company; (ii) being convicted
of a felony;  (iii) committing  an act  of  fraud  against  the Company or the
willful  material misappropriation of property belonging to the Company; (iv)
materially breaching any proprietary information agreement between you and the
Company or (v) willfully disregarding your duties despite adequate warnings from
the Board.

        (d)     "Change of Control" of the Company means and includes any of the
following:

                    (i)  Any  Person  or  "group"  (as that term is  defined  in
                         Section  13(d) of the  Exchange  Act and the  rules and
                         regulations  promulgated  thereunder) is or becomes, on
                         or prior to December 31, 2001,  the  Beneficial  Owner,
                         directly or

<PAGE>

                         indirectly, of securities of the Company representing
                         fifty percent (50%) or more of the voting power of then
                         outstanding securities of the Company.

                    (ii) Any  Person  or  group  is or  becomes,  on or prior to
                         December 31, 2001,  the Beneficial  Owner,  directly or
                         indirectly,  of securities of the Company  representing
                         twenty percent (20%) or more of the voting power of the
                         then outstanding securities of the Company, unless such
                         acquisition  was  approved in advance by the  Company's
                         Board of Directors.

                    (iii)The individuals who, as of the date hereof, are members
                         of the  Company's  Board of  Directors  (the  "Existing
                         Directors"),  cease,  on or prior to December 31, 2001,
                         for any reason,  to constitute  more than fifty percent
                         (50%) of the  number  of  authorized  directors  of the
                         Company as determined  in the manner  prescribed in the
                         Company's  Certificate  of  Incorporation  and  Bylaws;
                         provided,  however,  that  if the  appointment,  or the
                         election,  or nomination for election, by the Company's
                         stockholders  of any new  director,  was  approved by a
                         vote of at least fifty  percent  (50%) of the  Existing
                         Directors,  such new director  shall be  considered  an
                         Existing Director;  provided further,  however, that no
                         individual shall be considered an Existing  Director if
                         such individual initially assumed office as a result of
                         either an actual or  threatened  election  contest  (as
                         described  in Rule  14a-11 or,  effective  January  24,
                         2000,  Rule  14a-12(c)  promulgated  under the Exchange
                         Act) or other  actual  or  threatened  solicitation  of
                         proxies by or on behalf of anyone  other than the Board
                         of Directors (a "Proxy  Contest"),  including by reason
                         of any  agreement  intended  to  avoid  or  settle  any
                         election contest or Proxy Contest.

                    (iv) The consummation,  on or prior to December 31, 2001, of
                         a merger,  consolidation or reorganization to which the
                         Company is a party,  whether or not the  Company is the
                         Person  surviving  or  resulting   therefrom,   in  one
                         transaction or a series of related transactions, to any
                         Person(s) other than a Subsidiary,  provided,  however,
                         that no such transaction  shall constitute a "Change of
                         Control"  under this  subparagraph  (iv) if the Persons
                         who were the  stockholders  of the Company  immediately
                         before the  consummation  of such  transaction  are the
                         Beneficial    Owners,    immediately    following   the
                         consummation  of such  transaction,  of  fifty  percent
                         (50%) or more of the combined  voting power of the then
                         outstanding  voting  securities of the Person surviving
                         or  resulting   from  any  merger,   consolidation   or
                         reorganization.

                    (v)  The consummation,  on or prior to December 31, 2001, of
                         a  sale,   assignment,   lease,   conveyance  or  other
                         disposition  of 50% or more  of the  assets  or  assets
                         representing  50% or more of the  earning  power of the
                         Company, in one or a series of related  transactions to
                         any Person(s) other than a Subsidiary.

                    (vi) A complete liquidation of the Company.

        (e)     "COBRA" means the Consolidated Omnibus Budget Reconciliation Act
of 1985.

<PAGE>

        (f)      "Company" means Scios Inc., a Delaware corporation, and any
successor or assignee as provided in Article IV.

        (g)     "Compensation"  means the  highest  level of your annual base
salary at any time during  the 12 months preceding the date on which your
employment  is terminated  attributable  to your  employment with the Company
and/or any of its Subsidiaries  (including,  but not  limited  to, any  amounts
excluded  at your election  from your gross  income for federal  income tax
purposes  pursuant to Section 125 or Section 401(k) of the Internal  Revenue
Code of 1986, as amended, or deferred  pursuant to any Company or Subsidiary
plan or program),  plus your target bonus for the calendar year during which
your employment is terminated.

        (h)     "Disability"  means a physical or mental infirmity  which
substantially impairs your ability to perform  your  material  duties for a
period of at least one hundred  eighty  (180)  consecutive  calendar  days and,
as a result of such Disability,  you have not returned to your full-time regular
employment prior to termination.

        (i)     "ERISA" means the Employee Retirement Income Security Act of
1974, as amended.

        (j)     "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

        (k)     "Good Reason" means any of the  following: (i) relocation of the
Company's executive offices more than forty miles from the current location,
without your concurrence; (ii) any material  breach by the Company of any
provision of this Agreement; (iii) the assignment to you by the Company of any
duties inconsistent with your  status as an officer of the Company holding the
offices you hold immediately prior to the Change of Control or a substantial
adverse alteration in  the  nature or status of your responsibilities from those
in  effect immediately  prior to the Change of Control;  or (iv) a reduction in
the amount equal  to the sum of (x) your total annual cash salary and (y) your
bonus opportunity, in each case as in effect on the date hereof or as the same
may be increased from time to time.

        (l)     "Person" shall have the meaning ascribed to such term in Section
3 of the Exchange Act and the rules and regulations promulgated thereunder.

        (m)     "Severance Payment" means the payment of severance compensation
as provided in Article II.

        (n)     "Subsidiary" means any corporation or other Person, a majority
of the voting power, equity securities or equity interest of which is owned
directly  or indirectly by the Company.

<PAGE>

                                   ARTICLE II
                               SEVERANCE PAYMENTS

2.1      Right to Severance Payment

         You shall be entitled to receive a Severance  Payment  from the Company
in the amount  provided in Section 2.2 if (a) there has been a Change of Control
of the  Company,  (b) you are an active  employee  at the time of the  Change of
Control,  and (c) within three hundred  sixty five (365)  calendar days from and
including the date of the Change of Control,  your  employment is  involuntarily
terminated for any reason (other than for Cause or your death or Disability), or
you  voluntarily  terminate  your  employment  for Good Reason.  For purposes of
subclause (b) above,  you will still be  considered to be an active  employee if
you are on sick leave,  military leave or any other leave of absence approved by
the Company or any of its Subsidiaries.

2.2      Amount of Severance Payment

         If you become entitled to a Severance Payment under this Agreement, you
shall receive a lump sum payment equal to 1.5 times your Compensation.

2.3      Excise Tax Limitation

        (a)     Notwithstanding anything contained in this Agreement to the
contrary, in the event that any payment or benefit (within the meaning of
Section  28OG(b)(2) of the Internal Revenue Code of 1986, as amended (the
"Code")),  to you or for your benefit paid or payable or distributed or
distributable pursuant to the terms of this  Agreement or otherwise in
connection  with, or arising out of, your employment with the Company or any of
its Subsidiaries or a Change of Control (a "Payment" or "Payments"),  would be
subject to the excise tax imposed by Section 4999 of the Code (the "Excise
Tax"), then the Payments shall be reduced (but not below zero) but only to the
extent  necessary  that no portion  thereof shall be subject to the excise tax
imposed by Section 4999 of the Code (the "Section 4999 Limit").

        (b)     If a reduction in Payments is necessary to comply with the
provisions of the preceding  paragraph, you shall be entitled to select which
Payments  will be reduced and the manner and method of any such reduction of
such Payments. Within ten (10) calendar days after the amount of any required
reduction in Payments is finally determined in accordance with the provisions of
this Section 2.3, you shall notify the Company and the Accounting Firm (as
defined below) in writing regarding  which  Payments are to be reduced.  If you
fail to give such notification, the Company will determine which Payments to
reduce.

        (c)     All  determinations  required  to be made under this  Section
2.3 (each,  a "Determination")  shall be  made,  at the  Company's  expense, by
a  nationally recognized accounting  firm designated by the Company (other than
the Company's accounting  firm or the accounting firm that is regularly engaged
by any party who has effectuated the Change of Control) and reasonably
acceptable to you (the "Accounting Firm"). The Accounting Firm shall provide its
calculations, together with detailed  supporting  documentation,  both to the
Company and to you within ten (10) calendar days after the date on which your
right to a Severance Payment hereunder was triggered (if  requested at that time
by the Company or you) or such other

<PAGE>

time as requested by the Company or you (in either case provided that the
Company or you believe in good faith that any of the Payments may be subject to
the Excise Tax); provided, however, that if the Accounting Firm determines that
no Excise Tax is payable by you with respect to a Payment or  Payments, it shall
furnish you with written advice to the effect that no Excise Tax should be
imposed with respect to any such Payment or Payments.  Within ten (10) calendar
days of the  delivery of the  Determination to you, you shall have the right to
dispute the Determination (the "Dispute") in accordance with the provisions of
Section 7.11 and Article VI of this Agreement.  The existence of any Dispute
shall not in any way affect  your right to receive the Payments in accordance
with the  Determination.  If there is no Dispute, the Determination by the
Accounting Firm shall be final, binding and conclusive upon the Company and you,
subject to the application of Section 2.3(d).

        (d)     As a result of the uncertainty in the application of Sections
4999 and 28OG of the Code, it is possible that the Payments either will have
been made (or are due) or  will not have been made by the Company, in any  case
in a  manner inconsistent with the limitations provided in Section 2.3(a) (an
"Excess Payment" or "Underpayment", respectively). If it is established pursuant
to (i) a final determination of a court for which all appeals have been taken
and finally resolved or the time for all appeals has expired, or (ii) an
Internal Revenue Service (the "IRS")  proceeding  which has been finally and
conclusively resolved, that an Excess Payment has been made, any Payments
remaining to be paid  pursuant to Article II which constitute all or any portion
of the Excess Payment  will be eliminated  to the extent necessary so that the
Section 4999 Limit is (or would have been) satisfied and then any remaining
Excess Payment shall be deemed for all purposes to be a loan to you made on the
date you received such Excess Payment and you shall repay such Excess Payment to
the Company on demand, together with interest on such Excess Payment at the
applicable  federal  rate (as  defined in Section  1274(d) of the Code) from the
date of your receipt of such Excess Payment until the date of such repayment. If
it is determined  (i) by the  Accounting  Firm, the Company (which shall include
the position taken by the Company,  together with its consolidated group, on its
federal  income tax return) or the IRS, (ii) by a court,  or (iii) by resolution
to your  satisfaction  of the Dispute,  that an Underpayment  has occurred,  the
Company  shall pay an amount  equal to the  Underpayment  to you within ten (10)
calendar days of such  determination  or  resolution,  together with interest on
such amount at the applicable federal rate from the date such amount should have
been paid to you pursuant to the terms of this  Agreement or otherwise,  but for
the operation of this Section 2.3, until the date of payment.

2.4      No Duty of Mitigation

         The Company  acknowledges that it would be very difficult and generally
impracticable  to  determine  your  ability  to, or the extent to which you may,
mitigate  any  damages  or  injuries  you may incur by  reason of the  Change of
Control. The Company has taken this into account in entering into this Agreement
and,  accordingly,  the Company  acknowledges  and agrees that you shall have no
duty to mitigate any such damages and that you shall be entitled to receive your
entire  Severance  Payment  regardless  of any income which you may receive from
other sources  following the termination of your employment  after any Change of
Control.

<PAGE>

2.5      Time of Severance Payment

         The Severance  Payment to which you are entitled  shall be paid to you,
in cash and in full,  not  later  than  fifteen  (15)  calendar  days  after the
termination of your employment;  provided however, that if the release described
in Section  7.13 does not become  irrevocable  until a later date,  then payment
shall be made to you on the date the release becomes irrevocable.  If you should
die before all amounts  payable to you have been paid, such unpaid amounts shall
be paid to your beneficiary  under this Agreement or, if you have not designated
such a beneficiary in writing to the Company, to the personal  representative(s)
of your estate.

2.6      Health Care Benefits

         If you are entitled to receive a Severance  Payment  under Section 2.1,
you will also be  entitled  to  receive  health  care  benefits  (including  any
medical,  dental and vision coverage) for you and your dependents under the same
plan or plans under which you were covered  immediately prior to the termination
of your employment or substantially  similar plan(s)  established by the Company
or any of its Subsidiaries thereafter. Such health benefits shall be paid for by
the  Company  only to the same  extent  as if you  were  still  employed  by the
Company,  and you will be required  to pay for such health  benefits to the same
extent  that you would be  required  to do so if you were still  employed by the
Company.  This coverage will continue  under the Company's  plan for a period of
six months  following the termination of your  employment,  and the Company will
thereafter  pay for up to an  additional  12  months  if you  elect to  continue
benefits under COBRA. Notwithstanding the foregoing, your medical coverage under
this  Section  2.6 shall end as of the date you become  covered  under any other
group health plan not maintained by the Company or any of its Subsidiaries which
provides equal or greater benefits than such plan and which does not exclude any
pre-existing condition that you or your dependents may have at that time.

2.7      Outplacement Services

         If you are entitled to receive a Severance  Payment  under Section 2.1,
you will also be  entitled  to receive a range of  outplacement  services  by an
organization  selected by the Company.  These outplacement services will be paid
for by the Company up to a maximum of $10,000.

2.8      Withholding of Taxes

         The Company may withhold from any amounts  payable under this Agreement
all  federal,  state,  city or other  taxes  required  by  applicable  law to be
withheld by the Company.

2.9      No Setoff

         The Company's  obligation to make Severance Payments to you pursuant to
this Agreement and otherwise to perform its  obligations  hereunder shall not be
affected  by any  circumstances,  including,  but not  limited  to, any  setoff,
counterclaim, recoupment, defense or other right which the Company or any of its
Subsidiaries may have against you or others.

<PAGE>

                                  ARTICLE III
                            OTHER RIGHTS AND BENEFITS

3.1      Other Rights and Benefits

        (a)     This Agreement does not provide a pension for you nor shall
any payment hereunder be characterized as deferred compensation.

        (b)     The benefits that you may be entitled to receive pursuant to the
provisions of Article II are intended to be provided in lieu of and to replace
any similar or duplicative benefits to which you may be entitled from the
Company or any of its Subsidiaries in connection with the termination of your
employment after a Change of Control under any other severance plan, agreement,
policy or program maintained by the Company or any of its Subsidiaries.
Accordingly,  if you are entitled  to receive a  Severance  Payment under this
Agreement, you agree to relinquish all other  benefits you may be entitled to
receive under any such other severance plan, agreement, policy or program.

        (c)     Notwithstanding the provisions of paragraph (b) above, this
Agreement shall not act to reduce any amounts otherwise payable, or in any way
diminish your rights, whether existing now or hereafter, under any incentive,
retirement, pension, profit sharing, stock purchase or benefit plan or other
arrangement not related to severance following a Change of Control, and shall
not affect, enlarge or reduce your  rights with  respect to any stock options,
restricted stock or other equity interests that have been granted or issued to
you by the Company prior to the date hereof or in the future.

3.2      Employment Status.

         This  Agreement  does not constitute a contract of employment or impose
on you any obligation to remain in the employ of the Company, nor does it impose
on the Company or any of its  Subsidiaries  any obligation to retain you in your
present or any other  position,  or to change the status of your  employment  at
will.  Nothing in this Agreement  shall in any way require the Company or any of
its Subsidiaries to provide you with any severance benefits prior to a Change of
Control,  nor shall this Agreement ever be construed in any way as  establishing
any policies or requirements of the Company or any of its  Subsidiaries  for the
termination  of your  employment or the payment of severance  benefits to you if
your employment  terminates prior to a Change of Control,  nor shall anything in
this  Agreement  in any  way  affect  the  right  of the  Company  or any of its
Subsidiaries  in its absolute  discretion to change prior to a Change of Control
one or more benefit plans.

                                   ARTICLE IV
                              SUCCESSOR TO COMPANY

         The Company shall require any successor or assignee,  whether direct or
indirect,  by  purchase,   merger,   consolidation  or  otherwise,   to  all  or
substantially  all  the  business  or  assets  of  the  Company,  expressly  and
unconditionally  to assume and agree to perform the Company's  obligations under
this Agreement, in the same manner and to the same extent that the Company would
be required to perform if no such  succession or assignment had taken place.  In
such event,

<PAGE>

the term "Company," as used in this Agreement,  shall mean (from and
after,  but not  before,  the  occurrence  of such  event) the Company as herein
before  defined and any successor or assignee to the business or assets which by
reason hereof becomes bound by the terms and provisions of this Agreement.

                                   ARTICLE V
                             LEGAL FEES AND EXPENSES

         The  Company  shall pay as they  become  due all legal  fees,  costs of
litigation and other  expenses  incurred in good faith by you as a result of the
Company's  refusal or failure to make the Severance  Payment to which you become
entitled  under this  Agreement,  as a result of the  Company's  contesting  the
validity, enforceability or interpretation of this Agreement or of your right to
benefits  hereunder,  or with  regard to any  Dispute  (as  provided  in Section
2.3(c)). You shall be conclusively presumed to have acted in good faith unless a
court  makes a final  determination  not  otherwise  subject  to  appeal  to the
contrary.

                                   ARTICLE VI
                                   ARBITRATION

         Except as otherwise  provided in Section 2.3, and without  prejudice to
your rights  under  Section  7.11 and 7.12,  you shall have the right and option
(but not the obligation) to elect (in lieu of litigation) to have any dispute or
controversy  arising  under or in connection  with this  Agreement not otherwise
resolved through the claims  procedure set forth in Section 7.11,  including any
Dispute under Section 2.3,  settled by arbitration,  conducted by one arbitrator
sitting in a location  selected by you within fifty (50) miles from the location
of your job with the Company or any of its Subsidiaries,  in accordance with the
rules of the American Arbitration  Association then in effect.  Judgement may be
entered on the award of the  arbitrator  in any court having  jurisdiction.  All
expenses of such  arbitration,  including the fees and expenses of your counsel,
shall be borne, and paid as incurred, by the Company;  provided that the Company
shall only be  required to pay your fees and  expenses  if they are  incurred in
good  faith.  You shall be  conclusively  presumed  to have  acted in good faith
unless and until the arbitrator makes a final determination to the contrary.

                                  ARTICLE VII
                                  MISCELLANEOUS

7.1      Applicable Law

         To the extent not preempted by the laws of the United States and in the
interest of  interpreting  this Agreement in a uniform manner with other similar
agreements  being  entered  into  by the  Company  with  other  of its  and  its
Subsidiaries' employees regardless of the jurisdiction in which you are employed
or any  other  factor,  the  laws  of  the  State  of  California  shall  be the
controlling  law in all matters  relating to this  Agreement,  regardless of the
choice-of-law rules of the State of California or any other jurisdiction.

<PAGE>

7.2      Construction

         No term or  provision  of this  Agreement  shall be  construed so as to
require the  commission  of any act contrary to law,  and wherever  there is any
conflict  between  any  provision  of this  Agreement  and any present or future
statute,  law,  ordinance,  or regulation  contrary to which the parties have no
legal  right to  contract,  the  latter  shall  prevail,  but in such  event the
affected  provision of this  Agreement  affected  shall be curtailed and limited
only to the extent  necessary to bring such provision within the requirements of
the law.

7.3      Severability

         If a provision of this Agreement shall be held illegal or invalid,  the
illegality or invalidity  shall not affect the remaining parts of this Agreement
and this Agreement  shall be construed and enforced as if the illegal or invalid
provision had not been included.

7.4      Headings

         The Section headings in this Agreement are inserted only as a matter of
convenience,  and in no way define,  limit,  or extend or interpret the scope of
this Agreement or of any particular Section.

7.5      Notice of Termination

         Following  a Change  of  Control,  any  purported  termination  of your
employment by the Company or any of its Subsidiaries  shall be communicated by a
written notice of termination, which notice shall indicate, if it purports to be
based on Cause, the specific  reasons,  if any, relied upon and which sets forth
in reasonable detail the facts and circumstances  claimed to provide a basis for
termination of your employment.  The failure to provide such notice shall create
a rebuttable  presumption  that you are entitled to a Severance  Payment and the
other benefits provided by this Agreement.

7.6      Assignability

         Neither  this  Agreement  nor any right or  interest  therein  shall be
assignable or transferable  (whether by pledge, grant of a security interest, or
otherwise) by you, your beneficiaries or legal  representatives,  except by will
or by the laws of descent and distribution. This Agreement shall be binding upon
and shall inure to the benefit of the Company,  its successors and assigns,  and
you and shall be enforceable by them and your legal personal representatives.

7.7      Entire Agreement

         Except as otherwise  expressly  provided in Article III, this Agreement
constitutes  the entire  agreement  between the Company  and you  regarding  the
subject   matter  hereof  and   supersedes   all  prior   agreements,   if  any,
understandings  and arrangements,  written or oral,  between the Company and you
with respect to the subject matter hereof.

<PAGE>

7.8      Term

         If a Change of Control has not  theretofore  occurred,  this  Agreement
shall  expire  and be of no  further  force and  effect on  December  31,  2001;
provided  that the Board of  Directors  of the Company may, at any time prior to
the  expiration  thereof,  extend the term of this Agreement for a term of up to
two years,  including  changing the dates set forth in the definition of "Change
of Control", without any further action on your part.

         If a Change of Control  occurs,  this Agreement  shall continue in full
force and effect,  and shall not  terminate  or expire until the  expiration  of
three hundred  sixty six (366)  calendar days from and including the date of the
Change of Control,  at which time this Agreement shall  terminate  except if you
become  entitled to  Severance  Payments  hereunder  prior to such time.  If you
become so  entitled  to  Severance  Payments  hereunder,  this  Agreement  shall
continue and be effective until you (or the person(s)  specified in Section 2.5)
shall have received in full all Severance  Payments and other  benefits to which
you are  entitled  under  this  Agreement,  at which time this  Agreement  shall
terminate for all purposes.

7.9      Amendment

         Except as set forth in Section 7.8, no provision of this  Agreement may
be modified, waived or discharged unless such waiver,  modification or discharge
is agreed to in  writing  and  signed by you and the  Company.  No waiver by the
Company  or you at any time or any breach by the other  party of, or  compliance
with, any condition or provision of this Agreement to be performed by such other
party shall be deemed a waiver of similar or dissimilar provisions or conditions
at the same or any prior or subsequent  time.  No agreement or  representations,
written or oral, express or implied,  with respect to the subject matter hereof,
have  been  made by  either  party  which  are not  expressly  set forth in this
Agreement.

7.10     Notices

         For purposes of this  Agreement,  notices and all other  communications
provided  for herein  shall be in writing  and shall be deemed to have been duly
given when  personally  delivered  or sent by  certified  mail,  return  receipt
requested,  postage prepaid, addressed to the respective addresses last given by
each party to the other,  provided  that all  notices  to the  Company  shall be
directed to the attention of the Chairman of the Board of Directors  with a copy
to the General Counsel.  All notices and communications  shall be deemed to have
been received on the date of delivery thereof or on the third business day after
the mailing thereof,  except that notice of change of address shall be effective
only upon actual receipt.  No objection to the method of delivery may be made if
the written notice or other communication is actually received.

7.11     Claims

        (a)     If you believe you are entitled to a benefit under this
 Agreement, you may make a claim for such benefit by filing  with the Company a
written  statement setting  forth the amount and type of benefit so claimed.
The statement shall also set forth the facts supporting the claim. The claim may
be filed by mailing or delivering it to the Secretary of the Company.

<PAGE>

        (b)     Within fifteen (15) calendar days after receipt of such a claim,
the Company shall notify you in writing of its action on such claim and if such
claim is not allowed  in  full,  shall  state  the  following  in a manner
calculated  to be understood by you:

                    (i)  The specific reason or reasons for the denial;

                    (ii) Specific  reference  to  pertinent  provisions  of this
                         Agreement on which the denial is based;

                    (iii)A description of any additional material or information
                         necessary  for you to be entitled to the benefits  that
                         have  been  denied  and  an  explanation  of  why  such
                         material or information is necessary; and

                    (iv) An  explanation  of  this   Agreement's   claim  review
                         procedure.

        (c)     Without  prejudice to your rights under Article VI, if you
disagree with the action taken by the Company, you or your duly  authorized
representative  may apply to the Company for a review of such action. Such
application shall be made within  ninety (90) calendar days after receipt by you
of the notice of the Company's action on your claim. The application for review
shall be filed in the same manner as the claim for benefits.  In connection with
such review, you may inspect any documents or records pertinent to the matter
and may submit issues and  comments in writing to the  Company.  A decision  by
the  Company  shall be communicated  to you within  thirty  (30)  calendar  days
after receipt of the application.  The decision on review shall be in  writing
and shall include specific reasons for the decision,  written  in a  manner
calculated  to be understood by you, and specific references to the pertinent
provisions of this Agreement on which the decision is based.

7.12     Escrow.

        (a)     In the event that the  Company  denies, in whole or in part, a
claim for a benefit made by you under Section 7.11 hereof, or contests, in whole
or in part, your right to receive benefits under this Agreement, or otherwise
fails to make any cash payments or provide other benefits due under this
Agreement within ten (10) calendar days of the date such  payments or benefits
are due, the Company shall within ten (10) calendar days of receipt of your
written  demand, deposit the full  amount of the  benefit  which is claimed but
not paid, or the amount contested by the  Company, or the amount due, with an
escrow agent reasonably acceptable to you. The escrow agent shall be a
commercial bank or trust company having an aggregate capital and surplus in
excess of $50,000,000.

        (b)     Any  amounts deposited in escrow shall be held by the escrow
agent in an interest bearing account until the issuance of a final,
nonappealable order or decision by a court of competent jurisdiction or an
arbitral award under Article VI with respect to the claim, or amount contested
or not paid. At that time, to the extent that the order or decision is in your
favor, the amount in escrow or any portion thereof owing to you, including all
interest accrued on such amount, shall be paid to you.

<PAGE>

        (c)     The parties agree that if the Company fails to deposit the
required funds in escrow  pursuant to the provisions of paragraph (a) above,
then, in addition to all other remedies provided at law or in equity, you shall
be entitled, without the necessity of posting a bond, to seek equitable relief
to enforce the provisions of this Section 7.12. You shall be entitled to seek
any relief in any court of competent jurisdiction even if you have elected
to pursue arbitration of the dispute under Article VI of this Agreement.

7.13     General Release.

        (a)     A condition to your receipt of the Severance Payments under
Article II shall be your  execution  and delivery  (and  the  expiration of any
applicable revocability period afforded by law) of a full and complete release
by you of any and all claims you may have against the Company, any of its past,
present or future stockholders or any of their respective  officers,  directors,
employees and affiliates (past, present or future), including, but not limited
to, claims you might have relating to your employment  and/or  cessation of
employment with the Company, including without limitation, tort, contract and
common law claims and  claims  under  Title  VII  of  the  Civil  Rights  Act
of  1964, the  Age Discrimination in Employment Act of 1967, the Americans with
Disabilities Act of 1990, or any other similar federal, state or local statute,
rule or regulation; provided  that, there shall be excluded from the scope of
such general release the following:

          (i)  claims that you may have against the Company for reimbursement of
               reasonable and necessary business expenses incurred by you during
               the course of your employment;

          (ii) claims  that may be made by you for  payment of  accrued  salary,
               stock options,  pension benefits or other continuing  benefits as
               specifically  provided in Articles II and III of this  Agreement;
               and

          (iii)claims  respecting  matters  for  which  you are  entitled  to be
               indemnified  under the Company's  Certificate of Incorporation or
               Bylaws or  indemnification  agreements,  respecting  third  party
               claims asserted or third party  litigation  pending or threatened
               against you.

        (b)     The release shall be in a form reasonably satisfactory to the
Company and shall also include (i) appropriate provisions as necessary to insure
the release is valid and  enforceable  under  applicable  laws, including the
Older Workers Benefit  Protection Act, and (ii) a waiver of California Civil
Code Section 1542 (which provides that unless you specifically  agree to release
claims you do not know about, they are not released by a general release).  Such
payment shall be considered independent consideration made in exchange for such
release.

<PAGE>

         If this  Agreement is acceptable to you,  please sign the enclosed copy
of this Agreement in the space provided below and return it to me.

                                        Sincerely,



                                        Richard B. Brewer
                                        President and CEO

ACCEPTED AND AGREED TO:

______________________________
[Name]

Dated:________________________

<PAGE>

                       Supplemental Information Regarding

               Scios Inc. Officer Change of Control Severance Plan

         The Company has entered into  agreements  identical  to your  Agreement
with other officers of the Company or its Subsidiaries, other than the Company's
current CEO. These  agreements,  taken  together,  constitute a single  employee
welfare  benefit plan within the meaning of Section  3(1) of ERISA.  The name of
the plan is the  Scios  Inc.  Officer  Change  of  Control  Severance  Plan (the
"Plan").  The  Administrator of the Plan, within the meaning of Section 3(16) of
ERISA,  and the Named  Fiduciary  thereof,  within the meaning of Section 402 of
ERISA, is the Company.  A statement of Plan information and the rules applicable
under ERISA are set forth below:

         Claims Procedure.  Set forth in Section 7.11 of the Agreement

        Information  provided  under ERISA.  This Plan is an unfunded  severance
plan, maintained on a calendar year basis. In addition to constituting the Plan,
the  Agreement  and the  agreements  of the other  officers,  together with this
supplemental information, also constitutes the summary plan description required
by  ERISA.  The Plan  sponsor  is Scios  Inc.  which  bears the costs of all the
benefits  under  the  Plan.  The  Employer  Identification  number  of  Scios is
95-3701481;   and  the  Plan  number   assigned  by  Scios  is  505.   The  Plan
Administrator's  name,  business address,  and telephone number are: Scios Inc.,
820 West Maude Avenue,  Sunnyvale,  California 94086,  (408) 616-8200.  The Plan
Administrator is the agent for service of legal process.

         Statement of ERISA Rights.  A  participant  in this Plan is entitled to
certain  rights and  protections  under a federal  law known as  "ERISA."  ERISA
provides  that all Plan  participants  shall be  entitled  to  examine,  without
charge, at the Plan  Administrator's  office,  all Plan documents and the Plan's
annual report.  Copies of these documents and other Plan information may also be
obtained upon written request to the Plan Administrator. A reasonable charge may
be made for copies.

         In addition to creating rights for the Plan participants, ERISA imposes
duties upon the people who are  responsible  for the operation of this Plan. The
people who operate this Plan,  called  "fiduciaries" of the Plan, have a duty to
do so prudently and in the interest of you and other Plan participants.  No one,
including  your  employer,  or any  other  person,  may  fire  you or  otherwise
discriminate  against you in any way to prevent you from  obtaining  benefits or
exercising your rights under ERISA. If your claim benefits is denied in whole or
in part,  you must receive a written  explanation of the reason for this denial.
You have the right to have the Plan  Administrator  review and  reconsider  your
claim, as described elsewhere in this summary plan description.

         Under ERISA,  there are steps you can take to enforce the above rights,
For  instance,  if you request  materials  from the Plan and do not receive them
within 30 days, you may file suit in a federal court.  In such a case, the court
may require the Plan  Administrator  to provide the  materials and pay you up to
$100 a day until you receive the  materials,  unless the materials were

<PAGE>

not sent because of reasons beyond the control of the Plan  Administrator.  If
you have a claim for benefits which is denied or ignored, in whole or in part,
you may file a suit  in a state  or  federal  court.  If you are  discriminated
against  for asserting  your rights,  you may seek  assistance  from the U.S.
Department of Labor, or you may file suit in a federal court.  The court will
decide who should pay court costs and legal fees.  If you are  successful
the court may order the person you have sued to pay these costs and fees.  If
you lose, the court may order you to pay these costs and fees, for  example, if
it finds your claim is frivolous.

         If you have any questions  about your Plan, you should contact the Plan
Administrator.  If you have any  questions  about this  statement  or about your
rights  under  ERISA,  you should  contact the  nearest  Area Office of the U.S.
Labor-Management Services Administration, Department of Labor.




                                                                    EXHIBIT 99.7


                                   SCIOS INC.
                              820 West Maude Avenue
                           Sunnyvale, California 94086

January 11, 2000

Mr. Richard B. Brewer
President and
  Chief Executive Officer
Scios Inc.
820 West Maude Avenue
Sunnyvale, California 94086

Dear Dick:

         The Board of Directors of Scios Inc.  (the  "Company")  has  determined
that it is in the best  interests of the Company and its  stockholders  to offer
you the following  agreement (the  "Agreement")  which provides you with certain
severance  payments  and  benefits  if your  employment  terminates  following a
"Change of Control" (as defined below).

         This  Agreement  is intended to  supplement  your  existing  employment
agreement dated September 8, 1998 (the  "Employment  Agreement") in the event of
termination  following  a Change of Control,  and is not  intended to modify the
Employment Agreement except as set forth in Article III below.

                                   ARTICLE I
                                   DEFINITIONS

1.1      Definitions

         Whenever used in this Agreement,  the following capitalized terms shall
have the meanings set forth in this  Section,  certain other  capitalized  terms
being defined elsewhere in this Agreement:

        (a)     "Beneficial  Owner"  shall have the  meaning  ascribed to such
term in Rule 13d-3 promulgated under the Exchange Act.

        (b)     "Board of Directors" means the Board of Directors of the
Company.

        (c)     "Cause" means a termination for any of the following  reasons:
(i) engaging in  intentional  misconduct  which would tend to  discredit the
Company or your position as President and Chief Executive Officer; (ii) being
convicted of a felony;  (iii)  committing  an act of fraud  against the Company
or the willful material misappropriation of property belonging to the Company;
(iv) materially breaching the  Employment  Agreement or any proprietary
information agreement between you and the Company or (v) willfully  disregarding
your duties despite adequate warnings from the Board.

<PAGE>

        (d)     "Change of Control" of the Company means and includes any of the
following:

               (i)  Any  Person or  "group"  (as that term is defined in Section
                    13(d) of the  Exchange  Act and the  rules  and  regulations
                    promulgated  thereunder)  is  or  becomes,  on or  prior  to
                    December  31,  2001,  the  Beneficial  Owner,   directly  or
                    indirectly,  of securities of the Company representing fifty
                    percent   (50%)  or  more  of  the  voting   power  of  then
                    outstanding securities of the Company.

               (ii) Any Person or group is or  becomes,  on or prior to December
                    31, 2001, the Beneficial Owner,  directly or indirectly,  of
                    securities of the Company  representing twenty percent (20%)
                    or  more  of  the  voting  power  of  the  then  outstanding
                    securities  of the  Company,  unless  such  acquisition  was
                    approved in advance by the Company's Board of Directors.

               (iii)The individuals  who, as of the date hereof,  are members of
                    the Company's Board of Directors (the "Existing Directors"),
                    cease, on or prior to December 31, 2001, for any reason,  to
                    constitute  more than fifty  percent  (50%) of the number of
                    authorized  directors  of the Company as  determined  in the
                    manner   prescribed   in  the   Company's   Certificate   of
                    Incorporation  and Bylaws;  provided,  however,  that if the
                    appointment, or the election, or nomination for election, by
                    the Company's stockholders of any new director, was approved
                    by a vote of at least fifty  percent  (50%) of the  Existing
                    Directors, such new director shall be considered an Existing
                    Director;  provided  further,  however,  that no  individual
                    shall be considered an Existing  Director if such individual
                    initially  assumed office as a result of either an actual or
                    threatened election contest (as described in Rule 14a-11 or,
                    effective January 24, 2000, Rule 14a-12(c) promulgated under
                    the Exchange Act) or other actual or threatened solicitation
                    of proxies by or on behalf of anyone other than the Board of
                    Directors  (a "Proxy  Contest"),  including by reason of any
                    agreement  intended to avoid or settle any election  contest
                    or Proxy Contest.

               (iv) The  consummation,  on or prior to December 31,  2001,  of a
                    merger, consolidation or reorganization to which the Company
                    is a  party,  whether  or not  the  Company  is  the  Person
                    surviving or resulting  therefrom,  in one  transaction or a
                    series of related transactions,  to any Person(s) other than
                    a Subsidiary,  provided,  however,  that no such transaction
                    shall   constitute   a  "Change  of   Control"   under  this
                    subparagraph  (iv) if the Persons who were the  stockholders
                    of the Company  immediately  before the consummation of such
                    transaction are the Beneficial Owners, immediately following
                    the consummation of such transaction, of fifty percent (50%)
                    or more of the combined voting power of the then outstanding
                    voting  securities of the Person surviving or resulting from
                    any merger, consolidation or reorganization.

<PAGE>

               (v)  The  consummation,  on or prior to December 31,  2001,  of a
                    sale, assignment,  lease, conveyance or other disposition of
                    50% or more of the assets or assets representing 50% or more
                    of the earning  power of the Company,  in one or a series of
                    related   transactions   to  any  Person(s)   other  than  a
                    Subsidiary.

               (vi) A complete liquidation of the Company.

        (e)     "COBRA" means the Consolidated Omnibus Budget Reconciliation Act
of 1985.

        (f)     "Company" means Scios Inc., a Delaware corporation, and any
successor or assignee as provided in Article IV.

        (g)     "Compensation" means the highest level of your annual base
salary at any time during the 12 months preceding the date on which your
employment is terminated  attributable  to your  employment with the Company
and/or any of its Subsidiaries (including,  but not limited  to, any amounts
excluded  at your election  from your gross income for federal income tax
purposes pursuant to Section 125 or Section 401(k) of the Internal Revenue Code
of 1986, as amended, or deferred pursuant to any Company or Subsidiary plan or
program), plus your target bonus for the calendar year during which your
employment is terminated.

        (h)     "Disability" means a physical or mental infirmity which
substantially impairs your ability to perform your material duties for a period
of at least one hundred  eighty  (180)  consecutive  calendar  days and, as a
result of such Disability,  you have not returned to your full-time regular
employment prior to termination.

        (i)     "ERISA" means the Employee Retirement Income Security Act of
1974, as amended.

        (j)     "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

        (k)     "Good Reason" means any of the  following: (i) relocation of the
Company's executive offices more than forty miles from the current location,
without your concurrence; (ii) any material  breach by the Company of any
provision of this Agreement or the Employment Agreement; (iii) a material change
in the principal line of business of the Company, without your concurrence; (iv)
the assignment to you by the Company of any duties inconsistent with your status
as President and Chief Executive Officer or a substantial adverse alteration in
the nature or status of your responsibilities from those in effect immediately
prior to the Change of Control; or (v) a reduction in the amount equal to the
sum of (x) your total annual cash salary and (y) your bonus opportunity, in each
case as in effect on the date hereof or as the same may be increased from time
to time.

        (l)     "Person" shall have the meaning ascribed to such term in Section
3 of the Exchange Act and the rules and regulations promulgated thereunder.

        (m)     "Severance Payment" means the payment of severance compensation
as provided in Article II.

<PAGE>

        (n)     "Subsidiary" means any corporation or other Person, a majority
of the voting power, equity securities or equity interest of which is owned
directly or indirectly by the Company.

                                   ARTICLE II
                               SEVERANCE PAYMENTS

2.1      Right to Severance Payment

         You shall be entitled to receive a Severance  Payment  from the Company
in the amount  provided in Section 2.2 if (a) there has been a Change of Control
of the  Company,  (b) you are an active  employee  at the time of the  Change of
Control,  and (c) within three hundred  sixty five (365)  calendar days from and
including the date of the Change of Control,  your  employment is  involuntarily
terminated for any reason (other than for Cause or your death or Disability), or
you  voluntarily  terminate  your  employment  for Good Reason.  For purposes of
subclause (b) above,  you will still be  considered to be an active  employee if
you are on sick leave,  military leave or any other leave of absence approved by
the Company or any of its Subsidiaries.

2.2      Amount of Severance Payment

         If you become entitled to a Severance Payment under this Agreement, you
shall receive a lump sum payment equal to 2.25 times your Compensation.

2.3      Excise Tax Limitation

        (a)     Notwithstanding anything contained in this Agreement to the
contrary, in the event that any payment or benefit  (within the meaning of
Section  28OG(b)(2) of the Internal Revenue Code of 1986, as amended (the
"Code")),  to you or for your benefit paid or payable or distributed or
distributable pursuant to the terms of this  Agreement  or  otherwise  in
connection  with,  or arising  out of,  your employment with the Company or any
of its Subsidiaries or a Change of Control (a "Payment" or "Payments"),  would
be subject to the excise tax imposed by Section 4999 of the Code (the "Excise
Tax"), then the Payments shall be reduced (but not below zero) but only to the
extent  necessary  that no portion  thereof shall be subject to the excise tax
imposed by Section 4999 of the Code (the "Section 4999 Limit").

        (b)     If a reduction in Payments is necessary to comply with the
provisions of the preceding  paragraph,  you shall be entitled to select  which
Payments  will be reduced and the manner and method of any such reduction of
such Payments. Within ten (10) calendar days after the amount of any required
reduction in Payments is finally  determined in accordance  with the  provisions
of this Section 2.3, you shall notify the Company and the  Accounting  Firm (as
defined below) in writing regarding  which  Payments  are  to  be  reduced.  If
you  fail  to  give  such notification, the Company will determine which
Payments to reduce.

        (c)     All  determinations  required  to be made under this  Section
2.3 (each,  a "Determination")  shall be  made,  at the  Company's  expense,
by a  nationally recognized  accounting  firm designated by the Company (other
than the Company's accounting  firm or the accounting  firm that is regularly
engaged by any party who has effectuated the Change of

<PAGE>

Control) and reasonably acceptable to you (the "Accounting Firm"). The
Accounting Firm shall provide its calculations, together with detailed
supporting  documentation,  both to the Company and to you within
ten (10) calendar days after the date on which your right to a Severance Payment
hereunder  was  triggered  (if  requested at that time by the Company or you) or
such other time as requested by the Company or you (in either case provided that
the Company or you believe in good faith that any of the Payments may be subject
to the Excise Tax);  provided,  however,  that if the Accounting Firm determines
that no Excise Tax is payable by you with respect to a Payment or  Payments,  it
shall furnish you with written advice to the effect that no Excise Tax should be
imposed with respect to any such Payment or Payments.  Within ten (10)  calendar
days of the  delivery of the  Determination  to you, you shall have the right to
dispute the  Determination  (the "Dispute") in accordance with the provisions of
Section  7.11 and Article VI of this  Agreement.  The  existence  of any Dispute
shall not in any way affect  your right to receive the  Payments  in  accordance
with the  Determination.  If  there  is no  Dispute,  the  Determination  by the
Accounting Firm shall be final, binding and conclusive upon the Company and you,
subject to the application of Section 2.3(d).

        (d)     As a result of the  uncertainty in the application of Sections
4999 and 28OG of the Code, it is possible that the Payments either will have
been made (or are due) or  will  not  have  been  made by the  Company,  in any
case in a  manner inconsistent  with the  limitations  provided  in  Section
2.3(a)  (an  "Excess Payment" or "Underpayment",  respectively). If it is
established pursuant to (i) a final  determination  of a court  for which all
appeals  have been  taken and finally  resolved or the time for all appeals has
expired,  or (ii) an Internal Revenue Service (the "IRS")  proceeding  which has
been finally and conclusively resolved,  that an Excess  Payment has been made,
any Payments  remaining to be paid  pursuant to Article II which  constitute
all or any portion of the Excess Payment  will be  eliminated  to the extent
necessary  so that the Section 4999 Limit is (or would have been)  satisfied and
then any remaining  Excess  Payment shall  be  deemed  for all  purposes  to be
a loan to you  made on the  date you received  such Excess  Payment  and you
shall  repay such Excess  Payment to the Company  on  demand,  together  with
interest  on such  Excess  Payment  at the applicable  federal  rate (as defined
in Section  1274(d) of the Code) from the date of your receipt of such Excess
Payment until the date of such repayment. If it is determined  (i) by the
Accounting  Firm, the Company (which shall include the position taken by the
Company, together with its consolidated group, on its federal income tax return)
or the IRS, (ii) by a court,  or (iii) by resolution to your  satisfaction of
the Dispute,  that an Underpayment  has occurred, the Company  shall pay an
amount  equal to the  Underpayment  to you within ten (10) calendar days of such
determination  or  resolution,  together with interest on such amount at the
applicable federal rate from the date such amount should have been paid to you
pursuant to the terms of this  Agreement or otherwise,  but for the operation
of this Section 2.3, until the date of payment.

2.4      No Duty of Mitigation

         The Company  acknowledges that it would be very difficult and generally
impracticable  to  determine  your  ability  to, or the extent to which you may,
mitigate  any  damages  or  injuries  you may incur by  reason of the  Change of
Control. The Company has taken this into account in entering into this Agreement
and,  accordingly,  the Company  acknowledges  and agrees that you shall have no
duty to mitigate any such damages and that you shall be entitled to receive your

<PAGE>

entire  Severance  Payment  regardless  of any income which you may receive from
other sources  following the termination of your employment  after any Change of
Control.

2.5      Time of Severance Payment

         The Severance  Payment to which you are entitled  shall be paid to you,
in cash and in full,  not  later  than  fifteen  (15)  calendar  days  after the
termination of your employment;  provided however, that if the release described
in Section  7.13 does not become  irrevocable  until a later date,  then payment
shall be made to you on the date the release becomes irrevocable.  If you should
die before all amounts  payable to you have been paid, such unpaid amounts shall
be paid to your beneficiary  under this Agreement or, if you have not designated
such a beneficiary in writing to the Company, to the personal  representative(s)
of your estate.

2.6      Health Care Benefits

         If you are entitled to receive a Severance  Payment  under Section 2.1,
you will also be  entitled  to  receive  health  care  benefits  (including  any
medical,  dental and vision coverage) for you and your dependents under the same
plan or plans under which you were covered  immediately prior to the termination
of your employment or substantially  similar plan(s)  established by the Company
or any of its Subsidiaries thereafter. Such health benefits shall be paid for by
the  Company  only to the same  extent  as if you  were  still  employed  by the
Company,  and you will be required  to pay for such health  benefits to the same
extent  that you would be  required  to do so if you were still  employed by the
Company.  This coverage will continue  under the Company's  plan for a period of
six months  following the termination of your  employment,  and the Company will
thereafter  pay for up to an  additional  18  months  if you  elect to  continue
benefits under COBRA. Notwithstanding the foregoing, your medical coverage under
this  Section  2.6 shall end as of the date you become  covered  under any other
group health plan not maintained by the Company or any of its Subsidiaries which
provides equal or greater benefits than such plan and which does not exclude any
pre-existing condition that you or your dependents may have at that time.

2.7      Outplacement Services

         If you are entitled to receive a Severance  Payment  under Section 2.1,
you will also be  entitled  to receive a range of  outplacement  services  by an
organization  selected by the Company.  These outplacement services will be paid
for by the Company up to a maximum of $10,000.

2.8      Withholding of Taxes

         The Company may withhold from any amounts  payable under this Agreement
all  federal,  state,  city or other  taxes  required  by  applicable  law to be
withheld by the Company.

2.9      No Setoff

         The Company's  obligation to make Severance Payments to you pursuant to
this Agreement and otherwise to perform its  obligations  hereunder shall not be
affected  by any

<PAGE>

circumstances,  including,  but not  limited  to, any  setoff, counterclaim,
recoupment, defense or other right which the Company or any of its Subsidiaries
may have against you or others.

                                  ARTICLE III
                 OTHER RIGHTS AND BENEFITS; EMPLOYMENT AGREEMENT

3.1      Other Rights and Benefits

        (a)     This Agreement does not provide a pension for you nor shall any
payment hereunder be characterized as deferred compensation.

        (b)     The benefits that you may be entitled to receive pursuant to the
provisions of Article II are  intended to be provided in lieu of and to replace
any similar or duplicative  benefits to which you may be entitled from the
Company or any of its  Subsidiaries in connection with the termination of your
employment  after a Change of Control under any other severance plan, agreement,
policy or program maintained by the Company or any of its  Subsidiaries.
Accordingly,  if you are entitled  to receive a  Severance  Payment  under this
Agreement,  you agree to relinquish  all other  benefits  you may be entitled
to receive  under any such other  severance  plan,  agreement,  policy or
program,  except as  specifically provided below in Section 3.2.

        (c)     Notwithstanding the provisions of paragraph (b) above, this
Agreement shall not act to reduce any amounts otherwise  payable, or in any way
diminish  your rights,  whether  existing now or hereafter, under any incentive,
retirement, pension, profit sharing, stock purchase or benefit plan or other
arrangement not related  to  severance  following  a Change of  Control,  and
shall not  affect, enlarge or reduce  your  rights with  respect to any stock
options,  restricted stock or other equity  interests  that have been granted or
issued to you by the Company prior to the date hereof or in the future.

3.2      Employment Agreement

         This Agreement is intended to supplement your Employment Agreement only
with  respect to  Severance  Payments  in the event of the  termination  of your
employment  following a Change of Control. In the event you become entitled to a
Severance  Payment pursuant to Section 2.1 of this Agreement,  the provisions of
this  Agreement  will govern and  replace  the  benefits  you may  otherwise  be
entitled to receive  pursuant to Section 8 of the Employment  Agreement,  except
with respect to the vesting of your stock options and restricted  stock, and the
time of exercise of vested stock  options  which shall be treated as provided in
such  Section 8 (and  nothing  in this  Agreement  is  intended  to  affect  the
definition  of "Good  Reason" in Section 8 for  purposes  of such  vesting).  In
addition,  nothing in this Agreement,  including your entitlement to a Severance
Payment,  shall affect the  provisions of Section 7 (including the definition of
"Change  in  Control"  included  therein)  of  the  Employment  Agreement.  This
Agreement  does not  constitute  an  employment  agreement,  and  other  than as
specifically  provided in this Section 3.2,  this  Agreement  does not amend the
Employment  Agreement and the Employment Agreement will remain in full force and
effect with respect to the terms and conditions of your employment.

<PAGE>

                                   ARTICLE IV
                              SUCCESSOR TO COMPANY

         The Company shall require any successor or assignee,  whether direct or
indirect,  by  purchase,   merger,   consolidation  or  otherwise,   to  all  or
substantially  all  the  business  or  assets  of  the  Company,  expressly  and
unconditionally  to assume and agree to perform the Company's  obligations under
this Agreement, in the same manner and to the same extent that the Company would
be required to perform if no such  succession or assignment had taken place.  In
such event, the term "Company," as used in this Agreement,  shall mean (from and
after,  but not  before,  the  occurrence  of such  event) the Company as herein
before  defined and any successor or assignee to the business or assets which by
reason hereof becomes bound by the terms and provisions of this Agreement.

                                   ARTICLE V
                             LEGAL FEES AND EXPENSES

         The  Company  shall pay as they  become  due all legal  fees,  costs of
litigation and other  expenses  incurred in good faith by you as a result of the
Company's  refusal or failure to make the Severance  Payment to which you become
entitled  under this  Agreement,  as a result of the  Company's  contesting  the
validity, enforceability or interpretation of this Agreement or of your right to
benefits  hereunder,  or with  regard to any  Dispute  (as  provided  in Section
2.3(c)). You shall be conclusively presumed to have acted in good faith unless a
court  makes a final  determination  not  otherwise  subject  to  appeal  to the
contrary.

                                   ARTICLE VI
                                   ARBITRATION

         Except as otherwise  provided in Section 2.3, and without  prejudice to
your rights  under  Section  7.11 and 7.12,  you shall have the right and option
(but not the obligation) to elect (in lieu of litigation) to have any dispute or
controversy  arising  under or in connection  with this  Agreement not otherwise
resolved through the claims  procedure set forth in Section 7.11,  including any
Dispute under Section 2.3,  settled by arbitration,  conducted by one arbitrator
sitting in a location  selected by you within fifty (50) miles from the location
of your job with the Company or any of its Subsidiaries,  in accordance with the
rules of the American Arbitration  Association then in effect.  Judgement may be
entered on the award of the  arbitrator  in any court having  jurisdiction.  All
expenses of such  arbitration,  including the fees and expenses of your counsel,
shall be borne, and paid as incurred, by the Company;  provided that the Company
shall only be  required to pay your fees and  expenses  if they are  incurred in
good  faith.  You shall be  conclusively  presumed  to have  acted in good faith
unless and until the arbitrator makes a final determination to the contrary.

<PAGE>

                                  ARTICLE VII
                                  MISCELLANEOUS

7.1      Applicable Law

         To the extent not preempted by the laws of the United States and in the
interest of  interpreting  this Agreement in a uniform manner with other similar
agreements  being  entered  into  by the  Company  with  other  of its  and  its
Subsidiaries' employees regardless of the jurisdiction in which you are employed
or any  other  factor,  the  laws  of  the  State  of  California  shall  be the
controlling  law in all matters  relating to this  Agreement,  regardless of the
choice-of-law rules of the State of California or any other jurisdiction.

7.2      Construction

         No term or  provision  of this  Agreement  shall be  construed so as to
require the  commission  of any act contrary to law,  and wherever  there is any
conflict  between  any  provision  of this  Agreement  and any present or future
statute,  law,  ordinance,  or regulation  contrary to which the parties have no
legal  right to  contract,  the  latter  shall  prevail,  but in such  event the
affected  provision of this  Agreement  affected  shall be curtailed and limited
only to the extent  necessary to bring such provision within the requirements of
the law.

7.3      Severability

         If a provision of this Agreement shall be held illegal or invalid,  the
illegality or invalidity  shall not affect the remaining parts of this Agreement
and this Agreement  shall be construed and enforced as if the illegal or invalid
provision had not been included.

7.4      Headings

         The Section headings in this Agreement are inserted only as a matter of
convenience,  and in no way define,  limit,  or extend or interpret the scope of
this Agreement or of any particular Section.

7.5      Notice of Termination

         Following  a Change  of  Control,  any  purported  termination  of your
employment by the Company or any of its Subsidiaries  shall be communicated by a
written notice of termination, which notice shall indicate, if it purports to be
based on Cause, the specific  reasons,  if any, relied upon and which sets forth
in reasonable detail the facts and circumstances  claimed to provide a basis for
termination of your employment.  The failure to provide such notice shall create
a rebuttable  presumption  that you are entitled to a Severance  Payment and the
other benefits provided by this Agreement.

7.6      Assignability

         Neither  this  Agreement  nor any right or  interest  therein  shall be
assignable or transferable  (whether by pledge, grant of a security interest, or
otherwise) by you, your beneficiaries or legal  representatives,  except by will
or by the laws of descent and distribution. This Agreement shall

<PAGE>

be binding upon and shall inure to the benefit of the Company,  its successors
and assigns,  and you and shall be enforceable by them and your legal personal
representatives.

7.7      Entire Agreement

         Except as otherwise  expressly  provided in Article III, this Agreement
constitutes  the entire  agreement  between the Company  and you  regarding  the
subject   matter  hereof  and   supersedes   all  prior   agreements,   if  any,
understandings  and arrangements,  written or oral,  between the Company and you
with respect to the subject matter hereof.

7.8      Term

         If a Change of Control has not  theretofore  occurred,  this  Agreement
shall  expire  and be of no  further  force and  effect on  December  31,  2001;
provided  that the Board of  Directors  of the Company may, at any time prior to
the  expiration  thereof,  extend the term of this Agreement for a term of up to
two years,  including  changing the dates set forth in the definition of "Change
of Control", without any further action on your part.

         If a Change of Control  occurs,  this Agreement  shall continue in full
force and effect,  and shall not  terminate  or expire until the  expiration  of
three hundred  sixty six (366)  calendar days from and including the date of the
Change of Control,  at which time this Agreement shall  terminate  except if you
become  entitled to  Severance  Payments  hereunder  prior to such time.  If you
become so  entitled  to  Severance  Payments  hereunder,  this  Agreement  shall
continue and be effective until you (or the person(s)  specified in Section 2.5)
shall have received in full all Severance  Payments and other  benefits to which
you are  entitled  under  this  Agreement,  at which time this  Agreement  shall
terminate for all purposes.

7.9      Amendment

         Except as set forth in Section 7.8, no provision of this  Agreement may
be modified, waived or discharged unless such waiver,  modification or discharge
is agreed to in  writing  and  signed by you and the  Company.  No waiver by the
Company  or you at any time or any breach by the other  party of, or  compliance
with, any condition or provision of this Agreement to be performed by such other
party shall be deemed a waiver of similar or dissimilar provisions or conditions
at the same or any prior or subsequent  time.  No agreement or  representations,
written or oral, express or implied,  with respect to the subject matter hereof,
have  been  made by  either  party  which  are not  expressly  set forth in this
Agreement.

7.10     Notices

         For purposes of this  Agreement,  notices and all other  communications
provided  for herein  shall be in writing  and shall be deemed to have been duly
given when  personally  delivered  or sent by  certified  mail,  return  receipt
requested,  postage prepaid, addressed to the respective addresses last given by
each party to the other,  provided  that all  notices  to the  Company  shall be
directed to the attention of the Chairman of the Board of Directors  with a copy
to the General Counsel.  All notices and communications  shall be deemed to have
been received on the date of delivery thereof or on the third business day after
the mailing thereof,  except that notice of

<PAGE>

change of address shall be effective only upon actual receipt.  No objection to
the method of delivery may be made if the written notice or other communication
is actually received.

7.11     Claims

        (a)     If you believe you are entitled to a benefit under this
Agreement,  you may make a claim for such  benefit by filing  with the  Company
a written  statement setting  forth the amount and type of benefit so claimed.
The  statement  shall also set forth the facts supporting the claim. The claim
may be filed by mailing or delivering it to the Secretary of the Company.

        (b)     Within fifteen (15) calendar days after receipt of such a claim,
the Company shall notify you in writing of its action on such claim and if such
claim is not allowed  in  full,  shall  state  the  following  in a manner
calculated  to be understood by you:

               (i)  The specific reason or reasons for the denial;

               (ii) Specific reference to pertinent provisions of this Agreement
                    on which the denial is based;

               (iii)A  description  of any  additional  material or  information
                    necessary  for you to be entitled to the benefits  that have
                    been  denied  and an  explanation  of why such  material  or
                    information is necessary; and

               (iv) An explanation of this Agreement's claim review procedure.

        (c)     Without  prejudice to your rights under Article VI, if you
disagree with the action  taken by the Company,  you or your duly  authorized
representative  may apply to the Company for a review of such action. Such
application shall be made within  ninety  (90)  calendar  days  after  receipt
by you of the notice of the Company's action on your claim. The application for
review shall be filed in the same manner as the claim for benefits.  In
connection with such review,  you may inspect any documents or records pertinent
to the matter and may submit issues and  comments in writing to the  Company.  A
decision  by the  Company  shall be communicated  to you within  thirty  (30)
calendar  days  after  receipt of the application.  The  decision  on review
shall be in  writing  and shall  include specific  reasons  for  the decision,
written  in a  manner  calculated  to be understood by you, and specific
references to the pertinent  provisions of this Agreement on which the decision
is based.

7.12     Escrow.

        (a)     In the event that the  Company  denies,  in whole or in part,  a
claim for a benefit made by you under Section 7.11 hereof, or contests, in whole
or in part, your right to receive benefits under this Agreement,  or otherwise
fails to make any cash payments or provide other benefits due under this
Agreement  within ten (10)  calendar  days of the date such  payments or
benefits are due, the Company shall within ten (10) calendar days of receipt of
your written  demand,  deposit the full amount of the benefit  which is claimed
but not paid,  or the amount contested by the  Company, or the amount due, with
an escrow agent  reasonably acceptable to

<PAGE>

you. The escrow agent shall be a commercial  bank or trust company having an
aggregate capital and surplus in excess of $50,000,000.

        (b)     Any  amounts  deposited  in escrow  shall be held by the escrow
agent in an interest bearing account until the issuance of a final,
nonappealable  order or decision by a court of competent jurisdiction or an
arbitral award under Article VI with respect to the claim, or amount contested
or not paid. At that time, to the extent that the order or decision is in your
favor,  the amount in escrow or any portion thereof owing to you, including all
interest accrued on such amount,
shall be paid to you.

        (c)     The parties agree that if the Company fails to deposit the
required funds in escrow  pursuant to the provisions of paragraph (a) above,
then, in addition to all other remedies provided at law or in equity, you shall
be entitled,  without the  necessity  of  posting a bond,  to seek  equitable
relief to  enforce  the provisions of this Section 7.12. You shall be entitled
to seek any relief in any court of competent  jurisdiction even if you have
elected to pursue arbitration of the dispute under Article VI of this Agreement.

7.13     General Release.

        (a)     A condition to your receipt of the Severance Payments under
Article II shall be  your   execution  and  delivery  (and  the   expiration  of
any  applicable revocability  period  afforded by law) of a full and complete
release by you of any and all claims you may have against the Company, any of
its past, present or future stockholders or any of their respective  officers,
directors,  employees and affiliates (past, present or future),  including,
but not limited to, claims you might have relating to your employment  and/or
cessation of employment with the Company, including without limitation,  tort,
contract and common law claims and  claims  under  Title  VII  of  the  Civil
Rights  Act  of  1964,  the  Age Discrimination in Employment Act of 1967, the
Americans with Disabilities Act of 1990, or any other similar federal,  state or
local statute, rule or regulation; provided  that,  there shall be excluded from
the scope of such general  release the following:

               (i)  claims   that  you  may  have   against   the   Company  for
                    reimbursement of reasonable and necessary  business expenses
                    incurred by you during the course of your employment;

               (ii) claims  that  may be  made  by you for  payment  of  accrued
                    salary, stock options,  pension benefits or other continuing
                    benefits as specifically  provided in Articles II and III of
                    this Agreement; and

               (iii)claims  respecting  matters for which you are entitled to be
                    indemnified under the Company's Certificate of Incorporation
                    or Bylaws or  indemnification  agreements,  respecting third
                    party claims asserted or third party  litigation  pending or
                    threatened against you.

        (b)     The release shall be in a form  reasonably  satisfactory  to the
Company and shall also include (i) appropriate provisions as necessary to insure
the release is valid and  enforceable  under  applicable  laws,  including the
Older Workers Benefit  Protection Act, and (ii) a waiver of

<PAGE>

California Civil Code Section 1542 (which provides that unless you specifically
agree to release claims you do not know about, they are not released by a
general  release).  Such payment shall be considered independent consideration
made in exchange for such release.

         If this  Agreement is acceptable to you,  please sign the enclosed copy
of this Agreement in the space provided below and return it to me.

                                                Sincerely,

                                                /s/

                                                Donald B. Rice, Ph.D.
                                                Chairman of the Board

ACCEPTED AND AGREED TO:

/s/
_______________________________
Richard B. Brewer

Dated:  January 13, 2000

<PAGE>

                       Supplemental Information Regarding

                 Scios Inc. CEO Change of Control Severance Plan

         The Agreement constitutes a single employee welfare benefit plan within
the meaning of Section 3(1) of ERISA. The name of the plan is the Scios Inc. CEO
Change of Control  Severance Plan (the "Plan").  The  Administrator of the Plan,
within the meaning of Section 3(16) of ERISA,  and the Named Fiduciary  thereof,
within the meaning of Section 402 of ERISA, is the Company.  A statement of Plan
information and the rules applicable under ERISA are set forth below:

         Claims Procedure.  Set forth in Section 7.11 of the Agreement

        Information  provided  under ERISA.  This Plan is an unfunded  severance
plan, maintained on a calendar year basis. In addition to constituting the Plan,
the Agreement, together with this supplemental information, also constitutes the
summary plan description required by ERISA. The Plan sponsor is Scios Inc. which
bears the costs of all the benefits under the Plan. The Employer  Identification
number of Scios is 95-3701481; and the Plan number assigned by Scios is 506. The
Plan  Administrator's  name,  business address,  and telephone number are: Scios
Inc., 820 West Maude Avenue,  Sunnyvale,  California 94086, (408) 616-8200.  The
Plan Administrator is the agent for service of legal process.

         Statement of ERISA Rights.  A  participant  in this Plan is entitled to
certain  rights and  protections  under a federal  law known as  "ERISA."  ERISA
provides  that all Plan  participants  shall be  entitled  to  examine,  without
charge, at the Plan  Administrator's  office,  all Plan documents and the Plan's
annual report.  Copies of these documents and other Plan information may also be
obtained upon written request to the Plan Administrator. A reasonable charge may
be made for copies.

         In addition to creating rights for the Plan participants, ERISA imposes
duties upon the people who are  responsible  for the operation of this Plan. The
people who operate this Plan,  called  "fiduciaries" of the Plan, have a duty to
do so prudently and in the interest of you and other Plan participants.  No one,
including  your  employer,  or any  other  person,  may  fire  you or  otherwise
discriminate  against you in any way to prevent you from  obtaining  benefits or
exercising your rights under ERISA. If your claim benefits is denied in whole or
in part,  you must receive a written  explanation of the reason for this denial.
You have the right to have the Plan  Administrator  review and  reconsider  your
claim, as described elsewhere in this summary plan description.

         Under ERISA,  there are steps you can take to enforce the above rights,
For  instance,  if you request  materials  from the Plan and do not receive them
within 30 days, you may file suit in a federal court.  In such a case, the court
may require the Plan  Administrator  to provide the  materials and pay you up to
$100 a day until you receive the  materials,  unless the materials were not sent
because of reasons beyond the control of the Plan  Administrator.  If you have a
claim for benefits which is denied or ignored, in whole or in part, you may file
a suit  in a state  or  federal  court.  If you are  discriminated  against  for
asserting  your rights,  you may seek  assistance  from the U.S.  Department  of
Labor, or you may file suit in a federal court. The court will decide who

<PAGE>

should pay court costs and legal fees.  If you are  successful  the court may
order the person  you have sued to pay these  costs and fees.  If you lose,  the
court may order you to pay these costs and fees,  for  example,  if it finds
your claim is frivolous.

         If you have any questions  about your Plan, you should contact the Plan
Administrator.  If you have any  questions  about this  statement  or about your
rights  under  ERISA,  you should  contact the  nearest  Area Office of the U.S.
Labor-Management Services Administration, Department of Labor.



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