ENZON INC
5, 1996-03-01
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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FORM 5 

                                   U.S. SECURITIES AND EXCHANGE COMMISSION
                                         WASHINGTON, D.C. 20549
                         ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
<square>Check this box if no longer
subject to Section 16. Form 4         Filed pursuant to Section 16(a) of the
or Form 5 obligations           Securities Act of 1934, Section 17(a) of the 
may continue.  See             Public Utility Holding Company Act of 1935 or 
Instruction 1<b>.          Section 30(f) of the Investment Company Act of 1940

<square>Form 3 Holdings Reported
<square>Form 4 Transactions Reported
<TABLE>
<CAPTION>
1. Name and Address of Reporting Person        2. Issuer Name and Ticker or Trading Symbol 6.  Relationship of Reporting Person to
                                                                                           Issuer
                                                  ENZON, INC. (ENZN)                               (Check all applicable)
TOMBROS              PETER            G.                                                                     
<S>                                            <C>       <C>   <C> <C>       <C>    <C>    <C>             <C>         <C>
(Last)              (First)           (Middle) 3. IRS or Social    4. Statement for           X    Director       __10% Owner 
                                               Security Number of     Month/Year              X    Officer      __ Other
159 LAMBERT ROAD                               Reporting Person       JUNE 30, 1995   (give title below)     
                                              <Voluntary>                                        (specify below)
                                               
                                                                                             President & Chief Executive Officer
                   (Street)                                        5. If Amendment,
                                                                      Date of Original
NEW CANAAN                     CT   06840                            (Month/Year)
06840
(City)              (State)              (Zip)
                                                TABLE I - NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
1. Title of Security                           2. Trans- 3. Trans- 4. Securities Acquired  5. Amount of    6. Owner-   7. Nature of
   (Instr. 3)                                     action    action    (A) or Disposed of      Securities      ship        Indirect
                                                  Date      Code      (D)                     Beneficially    Form:       Beneficial
                                                  (Month/ (Instr.     (Instr. 3, 4 and 5)     Owned at End    (D) or      Ownership
                                                  Day/      8)                                   of Issuer's     Indirect    (Instr.
                                                  Year)                                          Fiscal Year     (I)         4)
                                                                                              (Instr. 3       (Instr.
                                                                                                and 4)          4)
                                                                    Amount   (A) or Price
                                                                               (D)
















</TABLE>
Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly.
                                               (Over)













<PAGE>

FORM 5 (CONTINUED)


   TABLE II - DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
                  (E.G., puts, calls, warrants, options, convertible securities)


<TABLE>
<CAPTION>
1. Title of Derivative   2.Conver3.Trans-4.Transac-5.Number of6.Date   7.Title and Amount of 8.Price9.Number10.        11.  Na-
Security                   sion   action tion  Deriv-        ExercisableUnder-lying            of    of       Owner-     ture
   (Instru. 3)             or     Date   Code  ative         and       Securities (Instr. 3    Deriv-Deriv-   ship        of In-
                           Exercise(Month/Day/(Instr.SecuritiesExpirationand 4)                ative ative     of De-     direct
                           Price  Year)8)      Ac-           Date                              Secur-Secur-               Bene-
                           of                  quired (A)    (Month/Day/                       ity   ities    rivative    ficial
                           Deriv-              or Disposed   Year)                             (Instr.Bene-               Own-
                           ative               of (D)                                          5)    ficially Security:     ership
                         Security              (Instr. 3,                                            Owned     (D)     (Instr. 4)
                                             4, and 5)                                               at        or In-
                                                                                                     End of    Direct
                                                                                                   Year
                                                                                                   (Instr.  (I)(Instr.
                                                                                                   4)       4)
<S>                      <C>    <C>    <C><C><C>       <C> <C>   <C>   <C>            <C>    <C>   <C>      <C>        <C>
                                                 (A)   (D) Date  Expira-    Title     Amount
                                                           Exer- tion                 or
                                                           cisableDate                Number
                                                                                      of
                                                                                      Shares
STOCK OPTION (RIGHT TO   $2.00  5/15/95A     84,000        ++    5/15/05Common Stock  84,000 $2.00 84,000   D          ----
PURCHASE)+
Stock option (right to   $2.09  1/20/95A     50,000        1/20/971/20/05Common Stock 50,000 $2.09 50,000   D          ----
purchase)+
STOCK OPTION (RIGHT TO   $2.63  8/24/94A     55,000        8/26/968/24/04COMMON STOCK 55,000 $2.63 55,000   D          ----
PURCHASE)+









</TABLE>


  Explanation of Responses:

  +    Granted under the Company's Non-Qualified Stock Option Plan, as amended,
       a Rule 16b-3 plan.

 ++    Exercisable as to 42,000 shares on May 15, 1996, and 42,000 shares on
       May 15, 1997.

*  Intentional misstatements or omissions of facts constitute Federal Criminal
   Violations .
                             /S/ PETER G. TOMBROS                  2/28/96
SEE 18 U.S.C. 1001 
and 15 U.S.C. 78ff(a). 
                            **Signature of Reporting Person        Date

Note:  File three copies of this Form, one of which must be manually signed.
   If space provided is insufficient, SEE Instruction 6 for procedure.

















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